Financial Metrics

ACAD ACADIA PHARMACEUTICALS INC

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2021-06-30	-0.27	—	USD/shares	10-Q	2022-08-09
Quarterly	2021-09-30	-0.09	+66.7%	USD/shares	10-Q	2022-11-03
Quarterly	2022-03-31	-0.7	-677.8%	USD/shares	10-Q	2023-05-08
Quarterly	2022-06-30	-0.21	+70.0%	USD/shares	10-Q	2023-08-03
Quarterly	2022-09-30	-0.17	+19.0%	USD/shares	10-Q	2023-11-03
Quarterly	2023-03-31	-0.27	-58.8%	USD/shares	10-Q	2024-05-09
Quarterly	2023-06-30	0.01	+103.7%	USD/shares	10-Q	2024-08-07
Quarterly	2023-09-30	-0.4	-4100.0%	USD/shares	10-Q	2024-11-07
Quarterly	2024-03-31	0.1	+125.0%	USD/shares	10-Q	2025-05-08
Quarterly	2024-06-30	0.2	+100.0%	USD/shares	10-Q	2025-08-07
Quarterly	2024-09-30	0.2	+0.0%	USD/shares	10-Q	2025-11-06
Quarterly	2025-03-31	0.11	-45.0%	USD/shares	10-Q	2025-05-08
Quarterly	2025-06-30	0.16	+45.5%	USD/shares	10-Q	2025-08-07
Quarterly	2025-09-30	0.42	+162.5%	USD/shares	10-Q	2025-11-06
Annual	2020-12-31	-1.79	—	USD/shares	10-K	2023-02-28
Annual	2021-12-31	-1.05	+41.3%	USD/shares	10-K	2024-02-28
Annual	2022-12-31	-1.34	-27.6%	USD/shares	10-K	2025-02-27
Annual	2023-12-31	-0.37	+72.4%	USD/shares	10-K	2026-02-26
Annual	2024-12-31	1.36	+467.6%	USD/shares	10-K	2026-02-26
Annual	2025-12-31	2.3	+69.1%	USD/shares	10-K	2026-02-26

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	207000.0	—	USD	10-Q	2017-05-09
Quarterly	2016-06-30	787000.0	+280.2%	USD	10-Q	2017-08-08
Quarterly	2016-09-30	1257000.0	+59.7%	USD	10-Q	2017-11-07
Quarterly	2017-03-31	485000.0	-61.4%	USD	10-Q	2018-05-04
Quarterly	2017-06-30	749000.0	+54.4%	USD	10-Q	2018-08-08
Quarterly	2017-09-30	805000.0	+7.5%	USD	10-Q	2018-11-06
Quarterly	2018-03-31	448000.0	-44.3%	USD	10-Q	2019-05-02
Quarterly	2018-06-30	563000.0	+25.7%	USD	10-Q	2019-08-01
Quarterly	2018-09-30	1578000.0	+180.3%	USD	10-Q	2019-10-31
Quarterly	2019-03-31	822000.0	-47.9%	USD	10-Q	2020-05-08
Quarterly	2019-06-30	842000.0	+2.4%	USD	10-Q	2020-08-06
Quarterly	2019-09-30	922000.0	+9.5%	USD	10-Q	2020-11-04
Quarterly	2020-03-31	934000.0	+1.3%	USD	10-Q	2021-05-06
Quarterly	2020-06-30	3867000.0	+314.0%	USD	10-Q	2021-08-05
Quarterly	2020-09-30	5588000.0	+44.5%	USD	10-Q	2021-11-09
Quarterly	2021-03-31	1076000.0	-80.7%	USD	10-Q	2022-05-05
Quarterly	2021-06-30	1121000.0	+4.2%	USD	10-Q	2022-08-09
Quarterly	2021-09-30	1121000.0	+0.0%	USD	10-Q	2022-11-03
Quarterly	2022-03-31	0.0	-100.0%	USD	10-Q	2022-05-05
Quarterly	2022-06-30	0.0	—	USD	10-Q	2022-08-09
Quarterly	2022-09-30	0.0	—	USD	10-Q	2023-11-03
Quarterly	2023-09-30	50000.0	—	USD	10-Q	2024-11-07
Quarterly	2024-06-30	0.0	-100.0%	USD	10-Q	2025-08-07
Quarterly	2024-09-30	70000.0	—	USD	10-Q	2025-11-06
Quarterly	2025-06-30	297000.0	+324.3%	USD	10-Q	2025-08-07
Quarterly	2025-09-30	685000.0	+130.6%	USD	10-Q	2025-11-06
Annual	2016-12-31	1506000.0	—	USD	10-K	2019-02-27
Annual	2017-12-31	812000.0	-46.1%	USD	10-K	2020-02-27
Annual	2018-12-31	2104000.0	+159.1%	USD	10-K	2021-02-25
Annual	2019-12-31	1129000.0	-46.3%	USD	10-K	2022-03-01
Annual	2020-12-31	7587000.0	+572.0%	USD	10-K	2023-02-28
Annual	2021-12-31	1122000.0	-85.2%	USD	10-K	2024-02-28
Annual	2022-12-31	0.0	-100.0%	USD	10-K	2025-02-27
Annual	2023-12-31	50000.0	—	USD	10-K	2026-02-26
Annual	2024-12-31	523000.0	+946.0%	USD	10-K	2026-02-26
Annual	2025-12-31	4690000.0	+796.7%	USD	10-K	2026-02-26

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	111346000.0	—	shares	10-Q	2017-05-09
Quarterly	2016-06-30	113308000.0	+1.8%	shares	10-Q	2017-08-08
Quarterly	2016-09-30	117497000.0	+3.7%	shares	10-Q	2017-11-07
Quarterly	2017-03-31	121651000.0	+3.5%	shares	10-Q	2018-05-04
Quarterly	2017-06-30	122122000.0	+0.4%	shares	10-Q	2018-08-08
Quarterly	2017-09-30	122484000.0	+0.3%	shares	10-Q	2018-11-06
Quarterly	2018-03-31	124727000.0	+1.8%	shares	10-Q	2019-05-02
Quarterly	2018-06-30	124910000.0	+0.1%	shares	10-Q	2019-08-01
Quarterly	2018-09-30	125009000.0	+0.1%	shares	10-Q	2019-10-31
Quarterly	2019-03-31	143981000.0	+15.2%	shares	10-Q	2020-05-08
Quarterly	2019-06-30	144314000.0	+0.2%	shares	10-Q	2020-08-06
Quarterly	2019-09-30	145906000.0	+1.1%	shares	10-Q	2020-11-04
Quarterly	2020-03-31	155368000.0	+6.5%	shares	10-Q	2021-05-06
Quarterly	2020-06-30	156535000.0	+0.8%	shares	10-Q	2021-08-05
Quarterly	2020-09-30	158129000.0	+1.0%	shares	10-Q	2021-11-09
Quarterly	2021-03-31	160011000.0	+1.2%	shares	10-Q	2022-05-05
Quarterly	2021-06-30	160421.0	-99.9%	shares	10-Q	2022-08-09
Quarterly	2021-09-30	160663.0	+0.2%	shares	10-Q	2022-11-03
Quarterly	2022-03-31	161231000.0	+100253.5%	shares	10-Q	2023-05-08
Quarterly	2022-06-30	161654.0	-99.9%	shares	10-Q	2023-08-03
Quarterly	2022-09-30	161852.0	+0.1%	shares	10-Q	2023-11-03
Quarterly	2023-03-31	162263000.0	+100153.9%	shares	10-Q	2024-05-09
Quarterly	2023-06-30	165046000.0	+1.7%	shares	10-Q	2024-08-07
Quarterly	2023-09-30	164234000.0	-0.5%	shares	10-Q	2024-11-07
Quarterly	2024-03-31	166623000.0	+1.5%	shares	10-Q	2025-05-08
Quarterly	2024-06-30	166174000.0	-0.3%	shares	10-Q	2025-08-07
Quarterly	2024-09-30	166178000.0	+0.0%	shares	10-Q	2025-11-06
Quarterly	2025-03-31	167668000.0	+0.9%	shares	10-Q	2025-05-08
Quarterly	2025-06-30	168681000.0	+0.6%	shares	10-Q	2025-08-07
Quarterly	2025-09-30	170650000.0	+1.2%	shares	10-Q	2025-11-06
Annual	2016-12-31	115858000.0	—	shares	10-K	2019-02-27
Annual	2017-12-31	122600000.0	+5.8%	shares	10-K	2020-02-27
Annual	2018-12-31	126583000.0	+3.2%	shares	10-K	2021-02-25
Annual	2019-12-31	147199000.0	+16.3%	shares	10-K	2022-03-01
Annual	2020-12-31	157331.0	-99.9%	shares	10-K	2023-02-28
Annual	2021-12-31	160493.0	+2.0%	shares	10-K	2024-02-28
Annual	2022-12-31	161683000.0	+100641.5%	shares	10-K	2025-02-27
Annual	2023-12-31	163819000.0	+1.3%	shares	10-K	2026-02-26
Annual	2024-12-31	166362000.0	+1.6%	shares	10-K	2026-02-26
Annual	2025-12-31	169919000.0	+2.1%	shares	10-K	2026-02-26

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

N/A

Total Liabilities (latest annual)

336,805,000

Current Liabilities (latest annual)

277,114,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-0.1118	—	ratio	10-Q	2017-05-09
Quarterly	2016-06-30	-0.1745	-56.1%	ratio	10-Q	2017-08-08
Quarterly	2016-09-30	-0.1239	+29.0%	ratio	10-Q	2017-11-07
Quarterly	2017-03-31	-0.1920	-55.0%	ratio	10-Q	2018-05-04
Quarterly	2017-06-30	-0.3741	-94.8%	ratio	10-Q	2018-08-08
Quarterly	2017-09-30	-0.5845	-56.3%	ratio	10-Q	2018-11-06
Quarterly	2018-03-31	-0.1785	+69.5%	ratio	10-Q	2019-05-02
Quarterly	2018-06-30	-0.4441	-148.8%	ratio	10-Q	2019-08-01
Quarterly	2018-09-30	-0.8042	-81.1%	ratio	10-Q	2019-10-31
Quarterly	2019-03-31	-0.2039	+74.6%	ratio	10-Q	2020-05-08
Quarterly	2019-06-30	-0.3606	-76.9%	ratio	10-Q	2020-08-06
Quarterly	2019-09-30	-0.2644	+26.7%	ratio	10-Q	2020-11-04
Quarterly	2020-03-31	-0.1379	+47.8%	ratio	10-Q	2021-05-06
Quarterly	2020-06-30	-0.1963	-42.4%	ratio	10-Q	2021-08-05
Quarterly	2020-09-30	-0.3280	-67.1%	ratio	10-Q	2021-11-09
Quarterly	2021-03-31	-0.1142	+65.2%	ratio	10-Q	2022-05-05
Quarterly	2021-06-30	-0.1953	-71.0%	ratio	10-Q	2022-08-09
Quarterly	2021-09-30	-0.2201	-12.7%	ratio	10-Q	2022-11-03
Quarterly	2022-03-31	-0.2542	-15.5%	ratio	10-Q	2023-05-08
Quarterly	2022-06-30	-0.3382	-33.1%	ratio	10-Q	2023-08-03
Quarterly	2022-09-30	-0.4093	-21.0%	ratio	10-Q	2023-11-03
Quarterly	2023-03-31	-0.1150	+71.9%	ratio	10-Q	2024-05-09
Quarterly	2023-06-30	-0.1059	+7.9%	ratio	10-Q	2024-08-07
Quarterly	2023-09-30	-0.2957	-179.2%	ratio	10-Q	2024-11-07
Quarterly	2024-03-31	0.0357	+112.1%	ratio	10-Q	2025-05-08
Quarterly	2024-06-30	0.0967	+170.9%	ratio	10-Q	2025-08-07
Quarterly	2024-09-30	0.1433	+48.3%	ratio	10-Q	2025-11-06
Quarterly	2025-03-31	0.0248	-82.7%	ratio	10-Q	2025-05-08
Quarterly	2025-06-30	0.0555	+123.7%	ratio	10-Q	2025-08-07
Quarterly	2025-09-30	0.1280	+130.6%	ratio	10-Q	2025-11-06
Annual	2016-12-31	-0.5235	—	ratio	10-K	2019-02-27
Annual	2017-12-31	-0.8632	-64.9%	ratio	10-K	2020-02-27
Annual	2018-12-31	-0.5118	+40.7%	ratio	10-K	2021-02-25
Annual	2019-12-31	-0.3365	+34.3%	ratio	10-K	2022-03-01
Annual	2020-12-31	-0.4491	-33.5%	ratio	10-K	2023-02-28
Annual	2021-12-31	-0.3104	+30.9%	ratio	10-K	2024-02-28
Annual	2022-12-31	-0.5394	-73.8%	ratio	10-K	2025-02-27
Annual	2023-12-31	-0.1419	+73.7%	ratio	10-K	2026-02-26
Annual	2024-12-31	0.3090	+317.7%	ratio	10-K	2026-02-26
Annual	2025-12-31	0.3186	+3.1%	ratio	10-K	2026-02-26

8-K Material Event Details

51 filings · 88 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

487 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-04-07	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	2,709	$22.20	$60,140	62,836
2026-04-05	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	5,276	$0.00	$0	0
2026-04-05	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	5,276	—	—	65,545
2026-03-25	Owen Adams Catherine	Chief Executive Officer	Open-market sell S	Common Stock	11,641	$21.47	$249,932	14,803
2026-03-24	Owen Adams Catherine	Chief Executive Officer	Exercise / conversion M · derivative	Restricted Stock Units	23,509	$0.00	$0	70,530
2026-03-24	Owen Adams Catherine	Chief Executive Officer	Exercise / conversion M	Common Stock	23,509	$0.00	$0	26,444
2026-03-06	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Equity grant / award A · derivative	Restricted Stock Units	6,332	$0.00	$0	6,332
2026-03-06	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Equity grant / award A · derivative	Stock Option (Right to Buy)	21,766	$0.00	$0	21,766
2026-03-03	Poole Jonathan	—	Equity grant / award A · derivative	Restricted Stock Units	2,010	$0.00	$0	2,010
2026-03-03	Poole Jonathan	—	Equity grant / award A · derivative	Restricted Stock Units	4,218	$0.00	$0	4,218
2026-03-03	Poole Jonathan	—	Equity grant / award A · derivative	Director Stock Options (Right to Buy)	3,565	$0.00	$0	3,565
2026-03-03	Poole Jonathan	—	Equity grant / award A · derivative	Director Stock Options (Right to Buy)	7,482	$0.00	$0	7,482
2026-02-09	Rhodes Jennifer J	EVP, CHIEF LEGAL OFFICER, SEC	Open-market sell S	Common Stock	6,950	$23.38	$162,491	7,609
2026-02-06	Rhodes Jennifer J	EVP, CHIEF LEGAL OFFICER, SEC	Exercise / conversion M · derivative	Restricted Stock Units	12,944	$0.00	$0	12,945
2026-02-06	Rhodes Jennifer J	EVP, CHIEF LEGAL OFFICER, SEC	Exercise / conversion M	Common Stock	12,944	$0.00	$0	14,559
2025-11-18	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	10,262	$23.69	$243,114	53,338
2025-11-17	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	9,913	$0.00	$0	0
2025-11-17	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	9,913	—	—	63,600
2025-11-10	Daly James M	—	Open-market sell S	Common Stock	30,000	$22.37	$670,983	4,041
2025-09-15	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	3,498	$23.65	$82,728	43,447
2025-09-12	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Equity grant / award A	Common Stock	6,815	$0.00	$0	46,945
2025-09-02	GAROFALO ELIZABETH A.	—	Open-market sell S	Common Stock	1,600	$25.98	$41,560	25,382
2025-08-18	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	22,000	$25.18	$554,024	40,130
2025-06-04	Brege Laura	—	Open-market sell S	Common Stock	14,446	$21.78	$314,634	15,095
2025-05-29	SOLAND DANIEL B	—	Equity grant / award A · derivative	Restricted Stock Units	8,107	$0.00	$0	8,107
2025-05-29	SOLAND DANIEL B	—	Equity grant / award A · derivative	Director Stock Options (Right to Buy)	13,793	$0.00	$0	13,793
2025-05-29	SOLAND DANIEL B	—	Exercise / conversion M · derivative	Restricted Stock Units	9,387	$0.00	$0	0
2025-05-29	SOLAND DANIEL B	—	Exercise / conversion M	Common Stock	9,387	—	—	44,041
2025-05-16	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Open-market sell S	Common Stock	2,000	$20.00	$40,000	20,395
2025-05-02	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Open-market sell S	Common Stock	1,327	$14.60	$19,374	23,526
2025-05-01	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	2,596	$0.00	$0	5,192
2025-05-01	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Exercise / conversion M	Common Stock	2,596	—	—	24,853
2025-04-08	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	2,708	$14.82	$40,133	59,456
2025-04-05	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	5,275	$0.00	$0	5,276
2025-04-05	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	5,275	—	—	62,164
2025-03-26	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Open-market sell S	Common Stock	1,095	$17.05	$18,670	21,275
2025-03-25	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	2,142	$0.00	$0	6,426
2025-03-25	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Exercise / conversion M	Common Stock	2,142	—	—	22,370
2025-03-24	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Equity grant / award A · derivative	Restricted Stock Units	6,510	$0.00	$0	6,510
2025-03-24	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Equity grant / award A · derivative	Stock Option (Right to Buy)	22,152	$0.00	$0	22,152
2025-03-05	GAROFALO ELIZABETH A.	—	Open-market sell S	Common Stock	4,919	$18.23	$89,673	17,595
2025-02-24	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Open-market sell S	Common Stock	475	$19.96	$9,481	20,228
2025-02-23	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	840	$0.00	$0	0
2025-02-23	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Exercise / conversion M	Common Stock	840	—	—	20,703
2024-12-09	Garner Thomas	EVP, Chief Commercial Officer	Equity grant / award A · derivative	Restricted Stock Units	45,372	$0.00	$0	45,372
2024-12-09	Garner Thomas	EVP, Chief Commercial Officer	Equity grant / award A · derivative	Stock Option (Right to Buy)	235,849	$0.00	$0	235,849
2024-11-19	Teehan Brendan	EVP, COO, HEAD OF COMMERCIAL	Open-market sell S	Common Stock	10,329	$16.81	$173,630	62,105
2024-11-17	Teehan Brendan	EVP, COO, HEAD OF COMMERCIAL	Exercise / conversion M · derivative	Restricted Stock Units	9,913	$0.00	$0	9,913
2024-11-17	Teehan Brendan	EVP, COO, HEAD OF COMMERCIAL	Exercise / conversion M	Common Stock	9,913	—	—	72,434
2024-10-12	Ndu Adora	—	Exercise / conversion M · derivative	Restricted Stock Units	4,381	$0.00	$0	0
2024-10-12	Ndu Adora	—	Exercise / conversion M	Common Stock	4,381	—	—	15,414
2024-09-23	Adams Catherine Owen	Chief Executive Officer	Equity grant / award A · derivative	Stock Option (Right to Buy)	353,261	$0.00	$0	353,261
2024-08-19	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	9,733	$15.28	$148,720	43,735
2024-08-16	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Equity grant / award A	Common Stock	13,629	$0.00	$0	53,468
2024-08-16	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Equity grant / award A	Common Stock	5,275	$0.00	$0	39,839
2024-08-12	Thompson Elizabeth H.Z.	EVP, Head of Research & Dev	Equity grant / award A · derivative	Restricted Stock Units	64,544	$0.00	$0	64,544
2024-08-12	Thompson Elizabeth H.Z.	EVP, Head of Research & Dev	Equity grant / award A · derivative	Stock Option (Right to Buy)	324,582	$0.00	$0	324,582
2024-06-10	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	975	$14.79	$14,420	34,564
2024-06-08	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	1,893	$0.00	$0	0
2024-06-08	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	1,893	—	—	35,539
2024-05-29	Ndu Adora	—	Equity grant / award A · derivative	Restricted Stock Units	9,387	$0.00	$0	9,387
2024-05-29	Ndu Adora	—	Equity grant / award A · derivative	Director Stock Options (Right to Buy)	15,959	$0.00	$0	15,959
2024-05-29	Ndu Adora	—	Exercise / conversion M · derivative	Restricted Stock Units	6,652	$0.00	$0	0
2024-05-29	Ndu Adora	—	Exercise / conversion M	Common Stock	6,652	—	—	11,033
2024-05-02	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	3,503	$16.94	$59,341	32,053
2024-05-01	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	6,814	$0.00	$0	20,445
2024-05-01	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	6,814	—	—	35,556
2024-04-08	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	17,716	$17.87	$316,585	144,267
2024-04-08	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	8,858	$17.87	$158,292	161,983
2024-04-05	DAVIS STEPHEN	CEO	Exercise / conversion M · derivative	Restricted Stock Units	34,666	$0.00	$0	138,666
2024-04-05	DAVIS STEPHEN	CEO	Exercise / conversion M · derivative	Restricted Stock Units	17,333	$0.00	$0	34,667
2024-04-05	DAVIS STEPHEN	CEO	Exercise / conversion M	Common Stock	34,666	—	—	170,841
2024-04-05	DAVIS STEPHEN	CEO	Exercise / conversion M	Common Stock	17,333	—	—	136,175
2024-03-25	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Equity grant / award A · derivative	Restricted Stock Units	8,568	$0.00	$0	8,568
2024-03-25	Kihara James	PRINCIPAL ACCOUNTING OFFICER	Equity grant / award A · derivative	Stock Options (Right to Buy)	13,964	$0.00	$0	13,964
2024-02-26	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	772	$24.67	$19,045	21,067
2024-02-23	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	1,353	$0.00	$0	1,353
2024-02-23	Schneyer Mark C.	EVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	1,353	—	—	21,839
2024-02-06	Rhodes Jennifer J	EVP, CHIEF LEGAL OFFICER, SEC	Equity grant / award A · derivative	Restricted Stock Units	25,889	$0.00	$0	25,889
2024-02-06	Rhodes Jennifer J	EVP, CHIEF LEGAL OFFICER, SEC	Equity grant / award A · derivative	Stock Option (Right to Buy)	126,589	$0.00	$0	126,589
2024-01-08	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	3,732	$29.96	$111,811	96,521
2024-01-06	DAVIS STEPHEN	CEO	Exercise / conversion M · derivative	Restricted Stock Units	9,528	$0.00	$0	0
2024-01-06	DAVIS STEPHEN	CEO	Exercise / conversion M	Common Stock	9,528	—	—	100,253
2023-12-15	Kihara James	Principal Accounting Officer	Open-market sell S	Common Stock	2,000	$28.30	$56,600	11,025
2023-11-24	GAROFALO ELIZABETH A.	Dir	Equity grant / award G	Common Stock	2,918	$0.00	$0	15,862
2023-11-20	Teehan Brendan	EVP, COO, Head of Commercial	Open-market sell S	Common Stock	4,960	$22.64	$112,294	30,393
2023-11-17	Teehan Brendan	EVP, COO, Head of Commercial	Exercise / conversion M · derivative	Restricted Stock Units	4,956	$0.00	$0	19,826
2023-11-17	Teehan Brendan	EVP, COO, Head of Commercial	Exercise / conversion M	Common Stock	4,956	—	—	35,353
2023-10-12	Ndu Adora	Dir	Exercise / conversion M · derivative	Restricted Stock Units	4,381	$0.00	$0	4,381
2023-10-12	Ndu Adora	Dir	Exercise / conversion M	Common Stock	4,381	—	—	4,381
2023-10-06	KIM AUSTIN D.	EVP,General Counsel, Secretary	Open-market sell S	Common Stock	16,369	$21.96	$359,463	45,857
2023-10-05	KIM AUSTIN D.	EVP,General Counsel, Secretary	Exercise / conversion M · derivative	Restricted Stock Units	36,174	$0.00	$0	60,289
2023-10-05	KIM AUSTIN D.	EVP,General Counsel, Secretary	Exercise / conversion M	Common Stock	36,174	—	—	62,226
2023-09-15	Kihara James	Principal Accounting Officer	Open-market sell S	Common Stock	2,000	$25.88	$51,760	10,778
2023-08-21	Schneyer Mark C.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	10,000	$29.00	$289,970	15,682
2023-07-14	DAVIS STEPHEN	CEO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	100,000	$0.00	$0	220,000
2023-07-14	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	100,000	$30.04	$3,004,350	36,695
2023-07-14	DAVIS STEPHEN	CEO	Exercise / conversion M	Common Stock	100,000	$20.77	$2,077,000	136,695
2023-07-12	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	55,104	$25.05	$1,380,449	36,695
2023-07-11	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	16,498	$25.00	$412,450	91,799
2023-06-15	Kihara James	Principal Accounting Officer	Open-market sell S	Common Stock	2,000	$24.15	$48,300	9,144
2023-06-12	Brege Laura	Dir	Open-market sell S	Common Stock	4,500	$24.87	$111,906	13,502
2023-06-08	Schneyer Mark C.	EVP, Chief Financial Officer	Exercise / conversion M · derivative	Restricted Stock Units	1,893	$0.00	$0	1,893
2023-06-08	Schneyer Mark C.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	974	$25.02	$24,369	22,824
2023-06-08	Schneyer Mark C.	EVP, Chief Financial Officer	Exercise / conversion M	Common Stock	1,893	$0.00	$0	23,798
2023-06-01	SOLAND DANIEL B	Dir	Equity grant / award A · derivative	Restricted Stock Units	6,652	$0.00	$0	6,652
2023-06-01	SOLAND DANIEL B	Dir	Equity grant / award A · derivative	Director Stock Options (Right to Buy)	11,045	$0.00	$0	11,045
2023-06-01	SOLAND DANIEL B	Dir	Exercise / conversion M · derivative	Restricted Stock Units	8,552	$0.00	$0	0
2023-06-01	SOLAND DANIEL B	Dir	Exercise / conversion M	Common Stock	8,552	—	—	28,002
2023-06-01	GAROFALO ELIZABETH A.	Dir	Equity grant / award A · derivative	Restricted Stock Units	6,652	$0.00	$0	6,652
2023-06-01	GAROFALO ELIZABETH A.	Dir	Equity grant / award A · derivative	Director Stock Options (Right to Buy)	11,045	$0.00	$0	11,045
2023-06-01	GAROFALO ELIZABETH A.	Dir	Exercise / conversion M · derivative	Restricted Stock Units	8,552	$0.00	$0	0
2023-06-01	GAROFALO ELIZABETH A.	Dir	Exercise / conversion M	Common Stock	8,552	—	—	18,780
2023-06-01	Ndu Adora	Dir	Equity grant / award A · derivative	Restricted Stock Units	6,652	$0.00	$0	6,652
2023-06-01	Ndu Adora	Dir	Equity grant / award A · derivative	Director Stock Options (Right to Buy)	11,045	$0.00	$0	11,045
2023-05-24	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	259,109	$25.65	$6,646,146	39,317,673
2023-05-24	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	24,113	$25.65	$618,498	3,610,443
2023-05-24	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	28,878	$25.51	$736,788	39,058,564
2023-05-24	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	2,688	$25.51	$68,581	3,586,330
2023-05-24	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	218,171	$25.27	$5,513,683	39,029,686
2023-05-24	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	20,304	$25.27	$513,129	3,583,642
2023-05-23	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	12,500	$0.00	$0	0
2023-05-23	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	74,582	$25.54	$1,904,824	38,811,515
2023-05-23	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	6,941	$25.54	$177,273	3,563,338
2023-05-23	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	116,672	$25.33	$2,955,325	38,736,933
2023-05-23	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	10,858	$25.33	$275,035	3,556,397
2023-05-23	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M	Common Stock	12,500	$17.01	$212,625	38,620,261
2023-05-22	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	40,632	$24.80	$1,007,674	38,607,761
2023-05-22	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	3,781	$24.80	$93,769	3,533,039
2023-05-22	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	82,148	$24.46	$2,009,373	38,567,129
2023-05-22	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	7,645	$24.46	$187,000	3,529,258
2023-05-17	Kihara James	Principal Accounting Officer	Exercise / conversion M · derivative	Restricted Stock Units	5,947	$0.00	$0	9,913
2023-05-17	Kihara James	Principal Accounting Officer	Open-market sell S	Common Stock	5,947	$22.50	$133,808	11,144
2023-05-17	Kihara James	Principal Accounting Officer	Exercise / conversion M	Common Stock	5,947	—	—	17,091
2023-05-01	KIM AUSTIN D.	EVP,General Counsel, Secretary	Open-market sell S	Common Stock	917	$21.18	$19,422	25,513
2023-05-01	Teehan Brendan	EVP, COO, Head of Commercial	Equity grant / award A · derivative	Restricted Stock Units	27,259	$0.00	$0	27,259
2023-05-01	Teehan Brendan	EVP, COO, Head of Commercial	Equity grant / award A · derivative	Stock Options (Right to Buy)	89,936	$0.00	$0	89,936
2023-04-29	KIM AUSTIN D.	EVP,General Counsel, Secretary	Exercise / conversion M · derivative	Restricted Stock Units	3,005	$0.00	$0	0
2023-04-29	KIM AUSTIN D.	EVP,General Counsel, Secretary	Exercise / conversion M	Common Stock	3,005	—	—	26,430
2023-04-10	Kihara James	Principal Accounting Officer	Open-market sell S	Common Stock	523	$18.14	$9,487	5,197
2023-04-07	Kihara James	Principal Accounting Officer	Exercise / conversion M · derivative	Restricted Stock Units	1,489	$0.00	$0	1,489
2023-04-07	Kihara James	Principal Accounting Officer	Exercise / conversion M	Common Stock	1,489	—	—	5,720
2023-04-06	Teehan Brendan	EVP, COO, Head of Commercial	Open-market sell S	Common Stock	1,751	$18.16	$31,798	8,468
2023-04-05	Teehan Brendan	EVP, COO, Head of Commercial	Exercise / conversion M · derivative	Restricted Stock Units	5,024	$0.00	$0	15,072
2023-04-05	Teehan Brendan	EVP, COO, Head of Commercial	Exercise / conversion M	Common Stock	5,024	—	—	10,219
2023-02-24	Kihara James	Principal Accounting Officer	Open-market sell S	Common Stock	350	$18.78	$6,573	2,923
2023-02-23	Kihara James	Principal Accounting Officer	Exercise / conversion M · derivative	Restricted Stock Units	840	$0.00	$0	1,680
2023-02-23	Kihara James	Principal Accounting Officer	Exercise / conversion M	Common Stock	840	—	—	3,273
2023-02-10	Williamson Douglas J	Executive VP, Research & Dev	Equity grant / award A · derivative	Restricted Stock Units	50,655	$0.00	$0	50,655
2023-02-10	Williamson Douglas J	Executive VP, Research & Dev	Equity grant / award A · derivative	Non-Qualified Stock Option (Right to Buy)	237,296	$0.00	$0	237,296
2023-01-12	Brege Laura	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	12,500	$0.00	$0	0
2023-01-12	Brege Laura	Dir	Open-market sell S	Common Stock	12,500	$18.25	$228,125	0
2023-01-12	Brege Laura	Dir	Exercise / conversion M	Common Stock	12,500	$17.01	$212,625	12,500
2023-01-09	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	3,904	$17.13	$66,877	84,633
2023-01-06	DAVIS STEPHEN	CEO	Exercise / conversion M · derivative	Restricted Stock Units	9,528	$0.00	$0	9,528
2023-01-06	DAVIS STEPHEN	CEO	Exercise / conversion M	Common Stock	9,528	—	—	88,537
2022-11-21	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Restricted Stock Units	6,250	$0.00	$0	0
2022-11-21	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	1,847	$15.07	$27,834	61,234
2022-11-19	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	6,250	—	—	63,081
2022-10-15	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Restricted Stock Units	2,969	$0.00	$0	0
2022-10-15	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	1,326	$15.81	$20,964	56,831
2022-10-15	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	2,969	—	—	58,157
2022-10-12	Ndu Adora	Dir	Equity grant / award A · derivative	Restricted Stock Units	8,762	$0.00	$0	8,762
2022-10-12	Ndu Adora	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	14,077	$0.00	$0	14,077
2022-09-29	GAROFALO ELIZABETH A.	Dir	Exercise / conversion M · derivative	Restricted Stock Units	1,919	$0.00	$0	0
2022-09-29	GAROFALO ELIZABETH A.	Dir	Exercise / conversion M	Common Stock	1,919	—	—	10,228
2022-06-09	Schneyer Mark C.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	653	$17.91	$11,695	3,342
2022-06-08	Schneyer Mark C.	EVP, Chief Financial Officer	Exercise / conversion M · derivative	Restricted Stock Units	1,893	$0.00	$0	3,786
2022-06-08	Schneyer Mark C.	EVP, Chief Financial Officer	Exercise / conversion M	Common Stock	1,893	$0.00	$0	3,995
2022-06-07	SOLAND DANIEL B	Dir	Exercise / conversion M · derivative	Restricted Stock Units	6,391	$0.00	$0	0
2022-06-07	SOLAND DANIEL B	Dir	Exercise / conversion M	Common Stock	6,391	—	—	19,450
2022-06-07	GAROFALO ELIZABETH A.	Dir	Exercise / conversion M · derivative	Restricted Stock Units	6,391	$0.00	$0	0
2022-06-07	GAROFALO ELIZABETH A.	Dir	Exercise / conversion M	Common Stock	6,391	—	—	8,309
2022-05-02	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	5,483	$18.18	$99,691	75,875
2022-04-29	DAVIS STEPHEN	CEO	Exercise / conversion M · derivative	Restricted Stock Units	15,625	$0.00	$0	15,625
2022-04-29	DAVIS STEPHEN	CEO	Exercise / conversion M	Common Stock	15,625	—	—	81,358
2022-04-08	Kihara James	Principal Accounting Officer	Open-market sell S	Common Stock	1,025	$27.05	$27,726	2,433
2022-04-07	Kihara James	Principal Accounting Officer	Exercise / conversion M · derivative	Restricted Stock Units	2,977	$0.00	$0	2,978
2022-04-07	Kihara James	Principal Accounting Officer	Exercise / conversion M	Common Stock	2,977	—	—	3,458
2022-04-05	Kihara James	Principal Accounting Officer	Equity grant / award A · derivative	Restricted Stock Units	8,039	$0.00	$0	8,039
2022-04-05	Kihara James	Principal Accounting Officer	Equity grant / award A · derivative	Stock Options (Right to Buy)	13,793	$0.00	$0	13,793
2022-02-23	Kihara James	Principal Accounting Officer	Exercise / conversion M · derivative	Restricted Stock Units	840	$0.00	$0	2,520
2022-02-23	Kihara James	Principal Accounting Officer	Open-market sell S	Common Stock	359	$23.80	$8,544	481
2022-02-23	Kihara James	Principal Accounting Officer	Exercise / conversion M	Common Stock	840	$0.00	$0	840
2022-01-06	Teehan Brendan	EVP, COO, Head of Commercial	Exercise / conversion M · derivative	Restricted Stock Units	1,286	$0.00	$0	2,573
2022-01-06	Teehan Brendan	EVP, COO, Head of Commercial	Open-market sell S	Common Stock	538	$23.05	$12,401	1,788
2022-01-06	Teehan Brendan	EVP, COO, Head of Commercial	Exercise / conversion M	Common Stock	1,286	—	—	2,326
2021-11-22	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	2,803	$19.01	$53,285	41,512
2021-11-19	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Restricted Stock Units	6,250	$0.00	$0	6,250
2021-11-19	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	6,250	—	—	44,315
2021-11-17	Kihara James	Principal Accounting Officer	Equity grant / award A · derivative	Restricted Stock Units	15,860	$0.00	$0	15,860
2021-10-18	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	1,338	$17.41	$23,295	38,065
2021-10-15	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Restricted Stock Units	2,969	$0.00	$0	2,969
2021-10-15	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	2,969	—	—	39,403
2021-09-29	GAROFALO ELIZABETH A.	Dir	Exercise / conversion M · derivative	Restricted Stock Units	1,918	$0.00	$0	1,919
2021-09-29	GAROFALO ELIZABETH A.	Dir	Exercise / conversion M	Common Stock	1,918	—	—	1,918
2021-06-22	SOLAND DANIEL B	Dir	Exercise / conversion M · derivative	Restricted Stock Units	3,059	$0.00	$0	0
2021-06-22	SOLAND DANIEL B	Dir	Exercise / conversion M	Common Stock	3,059	—	—	13,059
2021-04-30	Ridloff Elena	EVP and CFO	Open-market sell S	Common Stock	1,032	$20.33	$20,981	10,553
2021-04-29	Ridloff Elena	EVP and CFO	Exercise / conversion M · derivative	Restricted Stock Units	3,245	$0.00	$0	6,491
2021-04-29	Ridloff Elena	EVP and CFO	Exercise / conversion M	Common Stock	3,245	—	—	11,585
2021-02-23	Stankovic Srdjan R.	President	Equity grant / award A · derivative	Restricted Stock Units	19,677	$0.00	$0	19,677
2021-02-23	Stankovic Srdjan R.	President	Equity grant / award A · derivative	Stock Options (Right to Buy)	72,463	$0.00	$0	72,463
2021-02-04	Ridloff Elena	EVP and CFO	Open-market sell S	Common Stock	2,051	$50.61	$103,801	8,340
2021-02-04	Ridloff Elena	EVP and CFO	Equity grant / award A	Common Stock	6,490	$0.00	$0	10,391
2021-01-12	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Stock Option (Right to Buy)	700	$0.00	$0	89,562
2021-01-12	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	700	$55.01	$38,507	20,247
2021-01-12	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	700	$18.12	$12,684	20,947
2021-01-06	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M · derivative	Restricted Stock Units	2,722	$0.00	$0	8,167
2021-01-06	YANG MICHAEL J.	EVP and CCO	Open-market sell S	Common Stock	1,120	$53.34	$59,741	8,059
2021-01-06	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M	Common Stock	2,722	—	—	9,179
2020-11-20	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	2,728	$53.50	$145,948	16,528
2020-11-19	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Restricted Stock Units	6,250	$0.00	$0	12,500
2020-11-19	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	6,250	—	—	19,256
2020-10-27	KIM AUSTIN D.	EVP & General Counsel	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,750	$0.00	$0	113,750
2020-10-27	KIM AUSTIN D.	EVP & General Counsel	Open-market sell S	Common Stock	8,750	$45.10	$394,636	3,851
2020-10-27	KIM AUSTIN D.	EVP & General Counsel	Exercise / conversion M	Common Stock	8,750	$17.58	$153,825	12,601
2020-10-16	YANG MICHAEL J.	EVP and CCO	Open-market sell S	Common Stock	1,247	$42.56	$53,072	6,457
2020-10-15	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M · derivative	Restricted Stock Units	2,500	$0.00	$0	5,000
2020-10-15	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M	Common Stock	2,500	—	—	7,704
2020-09-29	GAROFALO ELIZABETH A.	Dir	Equity grant / award A · derivative	Restricted Stock Units	3,837	$0.00	$0	3,837
2020-09-29	GAROFALO ELIZABETH A.	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	6,865	$0.00	$0	6,865
2020-07-07	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	14,750	$0.00	$0	44,292
2020-07-07	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,000	$0.00	$0	25,000
2020-07-07	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,500	$0.00	$0	570,000
2020-07-07	YANG MICHAEL J.	EVP and CCO	Open-market sell S	Common Stock	11,100	$56.54	$627,574	5,204
2020-07-07	YANG MICHAEL J.	EVP and CCO	Open-market sell S	Common Stock	16,150	$56.05	$905,212	16,304
2020-07-07	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M	Common Stock	14,750	$25.12	$370,520	32,454
2020-07-07	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M	Common Stock	5,000	$21.28	$106,400	17,704
2020-07-07	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M	Common Stock	7,500	$19.98	$149,850	12,704
2020-06-23	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A · derivative	Non-Qualified Stock Options (right to buy)	11,158	$0.00	$0	11,158
2020-06-23	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	6,118	$0.00	$0	38,440,095
2020-06-19	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Employee Stock Option (Right to Buy)	16,452	$0.00	$0	93,750
2020-06-19	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	16,452	$50.12	$824,515	11,334
2020-06-19	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	16,452	$18.12	$298,110	27,786
2020-06-18	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Employee Stock Option (Right to Buy)	39,798	$0.00	$0	110,202
2020-06-18	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Employee Stock Option (Right to Buy)	17,494	$0.00	$0	34,112
2020-06-18	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Employee Stock Option (Right to Buy)	8,551	$0.00	$0	0
2020-06-18	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	65,843	$50.01	$3,292,729	11,334
2020-06-18	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	39,798	$18.12	$721,140	77,177
2020-06-18	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	17,494	$19.98	$349,530	37,379
2020-06-18	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	8,551	$19.65	$168,027	19,885
2020-05-14	DAVIS STEPHEN	CEO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	88,542	$0.00	$0	100,000
2020-05-14	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	4,321	$45.01	$194,509	11,809
2020-05-14	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	84,221	$45.65	$3,844,596	16,130
2020-05-14	DAVIS STEPHEN	CEO	Exercise / conversion M	Common Stock	88,542	$19.65	$1,739,850	100,351
2020-05-13	DAVIS STEPHEN	CEO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	111,458	$0.00	$0	188,542
2020-05-13	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	8,197	$45.12	$369,827	11,809
2020-05-13	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	63,392	$45.71	$2,897,858	20,006
2020-05-13	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	20,756	$46.43	$963,705	83,398
2020-05-13	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	5,205	$48.60	$252,953	104,154
2020-05-13	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	13,908	$48.98	$681,244	109,359
2020-05-13	DAVIS STEPHEN	CEO	Exercise / conversion M	Common Stock	111,458	$19.65	$2,190,150	123,267
2020-05-11	Daly James M	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	15,000	$0.00	$0	0
2020-05-11	Daly James M	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	11,250	$0.00	$0	11,250
2020-05-11	Daly James M	Dir	Open-market sell S	Common Stock	26,250	$51.13	$1,342,178	0
2020-05-11	Daly James M	Dir	Exercise / conversion M	Common Stock	15,000	$27.25	$408,750	26,250
2020-05-11	Daly James M	Dir	Exercise / conversion M	Common Stock	11,250	$25.24	$283,950	11,250
2020-04-30	KIM AUSTIN D.	EVP & General Counsel	Open-market sell S	Common Stock	1,072	$49.22	$52,764	2,441
2020-04-29	KIM AUSTIN D.	EVP & General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	3,004	$0.00	$0	9,015
2020-04-29	KIM AUSTIN D.	EVP & General Counsel	Exercise / conversion M	Common Stock	3,004	—	—	3,513
2020-04-23	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Employee Stock Option (Right to Buy)	11,875	$0.00	$0	35,625
2020-04-23	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Employee Stock Option (Right to Buy)	7,074	$0.00	$0	8,551
2020-04-23	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	18,949	$50.07	$948,729	6,027
2020-04-23	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	11,875	$21.28	$252,700	24,976
2020-04-23	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	7,074	$19.65	$139,004	13,101
2020-04-22	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Employee Stock Option (Right to Buy)	19,644	$0.00	$0	51,606
2020-04-22	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Employee Stock Option (Right to Buy)	34,375	$0.00	$0	15,625
2020-04-22	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	54,019	$50.02	$2,701,906	6,027
2020-04-22	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	19,644	$19.98	$392,487	60,046
2020-04-22	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	34,375	$19.65	$675,469	40,402
2020-04-20	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Employee Stock Option (Right to Buy)	100,000	$0.00	$0	50,000
2020-04-20	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	100,000	$50.15	$5,015,450	6,027
2020-04-20	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	100,000	$19.65	$1,965,000	106,027
2020-03-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	42,473	$34.47	$1,463,896	38,433,977
2020-03-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	3,837	$34.47	$132,248	3,470,609
2020-03-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	33,464	$33.63	$1,125,465	38,391,504
2020-03-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	3,023	$33.63	$101,670	3,466,772
2020-03-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	2,201	$32.85	$72,302	38,358,040
2020-03-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	199	$32.85	$6,537	3,463,749
2020-03-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	46,225	$32.61	$1,507,268	38,355,839
2020-03-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	4,175	$32.61	$136,135	3,463,550
2020-03-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	275	$31.93	$8,782	38,309,614
2020-03-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	25	$31.93	$798	3,459,375
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	93,006	$33.86	$3,149,406	38,309,339
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	8,402	$33.86	$284,512	3,459,350
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	24,223	$32.32	$782,873	38,216,333
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	2,188	$32.32	$70,715	3,450,948
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	29,624	$32.19	$953,620	38,192,110
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	2,676	$32.19	$86,143	3,448,760
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	7,612	$31.83	$242,290	38,162,486
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	688	$31.83	$21,899	3,446,084
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	43,212	$31.74	$1,371,359	38,154,874
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	3,903	$31.74	$123,864	3,445,396
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	3,913	$31.00	$121,285	38,111,662
2020-03-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	353	$31.00	$10,941	3,441,493
2020-03-16	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	631,281	$31.51	$19,893,937	38,107,749
2020-03-16	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	57,022	$31.51	$1,796,968	3,441,140
2020-03-16	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	5,503	$31.19	$171,613	37,476,468
2020-03-16	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	497	$31.19	$15,499	3,384,118
2020-01-07	Brege Laura	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	10,000	$0.00	$0	0
2020-01-07	Brege Laura	Dir	Open-market sell S	Common Stock	10,000	$42.19	$421,900	0
2020-01-07	Brege Laura	Dir	Exercise / conversion M	Common Stock	10,000	$1.75	$17,500	10,000
2020-01-06	YANG MICHAEL J.	EVP and CCO	Equity grant / award A · derivative	Restricted Stock Units	10,889	$0.00	$0	10,889
2020-01-06	YANG MICHAEL J.	EVP and CCO	Equity grant / award A · derivative	Stock Options (Right to Buy)	39,516	$0.00	$0	39,516
2019-12-12	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	72,979	$0.00	$0	312,500
2019-12-12	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	10,000	$0.00	$0	30,000
2019-12-12	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	22,500	$0.00	$0	577,500
2019-12-12	YANG MICHAEL J.	EVP and CCO	Open-market sell S	Common Stock	5,032	$43.73	$220,075	2,499
2019-12-12	YANG MICHAEL J.	EVP and CCO	Open-market sell S	Common Stock	100,447	$44.49	$4,469,188	7,531
2019-12-12	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M	Common Stock	72,979	$35.86	$2,617,027	107,978
2019-12-12	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M	Common Stock	10,000	$21.28	$212,800	34,999
2019-12-12	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M	Common Stock	22,500	$19.98	$449,550	24,999
2019-12-11	KIM AUSTIN D.	EVP & General Counsel	Exercise / conversion M · derivative	Stock Option (Right to Buy)	17,500	$0.00	$0	122,500
2019-12-11	KIM AUSTIN D.	EVP & General Counsel	Open-market sell S	Common Stock	17,500	$45.06	$788,576	509
2019-12-11	KIM AUSTIN D.	EVP & General Counsel	Exercise / conversion M	Common Stock	17,500	$17.58	$307,650	18,009
2019-12-09	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	14,521	$0.00	$0	385,479
2019-12-09	YANG MICHAEL J.	EVP and CCO	Open-market sell S	Common Stock	3,502	$50.05	$175,286	1,623
2019-12-09	YANG MICHAEL J.	EVP and CCO	Open-market sell S	Common Stock	11,019	$50.59	$557,506	5,125
2019-12-09	YANG MICHAEL J.	EVP and CCO	Exercise / conversion M	Common Stock	14,521	$35.86	$520,723	16,144
2019-12-05	DAVIS STEPHEN	CEO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	150,000	$0.00	$0	300,000
2019-12-05	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	28,256	$51.32	$1,450,098	2,954
2019-12-05	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	40,159	$52.09	$2,091,882	31,210
2019-12-05	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	81,585	$52.82	$4,309,320	71,369
2019-12-05	DAVIS STEPHEN	CEO	Exercise / conversion M	Common Stock	150,000	$19.65	$2,947,500	152,954
2019-11-19	Stankovic Srdjan R.	President	Exercise / conversion M · derivative	Restricted Stock Units	6,250	$0.00	$0	18,750
2019-11-19	Stankovic Srdjan R.	President	Open-market sell S	Common Stock	2,160	$46.41	$100,246	6,027
2019-11-19	Stankovic Srdjan R.	President	Exercise / conversion M	Common Stock	6,250	—	—	8,187
2019-10-15	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M · derivative	Restricted Stock Units	417	$0.00	$0	1,254
2019-10-15	Miller Eric Alejandro	Controller & PAO	Open-market sell S	Common Stock	147	$39.65	$5,829	270
2019-10-15	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M	Common Stock	417	—	—	417
2019-10-10	DAVIS STEPHEN	CEO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	120,208	$0.00	$0	450,000
2019-10-10	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	120,208	$40.19	$4,831,039	0
2019-10-10	DAVIS STEPHEN	CEO	Exercise / conversion M	Common Stock	120,208	$19.65	$2,362,087	120,208
2019-10-09	DAVIS STEPHEN	CEO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	29,792	$0.00	$0	570,208
2019-10-09	DAVIS STEPHEN	CEO	Open-market sell S	Common Stock	29,792	$40.00	$1,191,710	0
2019-10-09	DAVIS STEPHEN	CEO	Exercise / conversion M	Common Stock	29,792	$19.65	$585,413	29,792
2019-09-20	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	1,494,025	$40.00	$59,761,000	37,470,965
2019-09-20	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	68,475	$40.00	$2,739,000	3,383,621
2019-09-11	Miller Eric Alejandro	Controller & PAO	Open-market sell S	Common Stock	4,645	$41.18	$191,281	0
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,972	$0.00	$0	3,598
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,593	$0.00	$0	4,594
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,439	$0.00	$0	2,911
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	6,063	$0.00	$0	552
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,900	$0.00	$0	0
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,500	$0.00	$0	0
2019-09-09	Miller Eric Alejandro	Controller & PAO	Open-market sell S	Common Stock	28,467	$39.49	$1,124,162	4,645
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M	Common Stock	1,972	$16.50	$32,538	33,112
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M	Common Stock	4,593	$35.80	$164,429	31,140
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M	Common Stock	4,439	$36.54	$162,201	26,547
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M	Common Stock	6,063	$29.24	$177,282	22,108
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M	Common Stock	3,900	$32.28	$125,892	16,045
2019-09-09	Miller Eric Alejandro	Controller & PAO	Exercise / conversion M	Common Stock	7,500	$20.65	$154,875	12,145
2019-06-26	SOLAND DANIEL B	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	22,500	$0.00	$0	22,500
2019-06-06	BAKER BROS. ADVISORS LP	Dir	Other acquired transaction J	Common Stock	31,229	$0.00	$0	102,876
2019-06-06	BAKER BROS. ADVISORS LP	Dir	Other disposed transaction J	Common Stock	421,756	$0.00	$0	3,315,146
2019-04-29	Miller Eric Alejandro	Controller & PAO	Equity grant / award A · derivative	Restricted Stock Units	3,442	$0.00	$0	3,442
2019-04-29	Miller Eric Alejandro	Controller & PAO	Equity grant / award A · derivative	Stock Options (Right to Buy)	6,039	$0.00	$0	6,039
2019-04-01	Ridloff Elena	EVP and CFO	Equity grant / award A · derivative	Restricted Stock Units	40,000	$0.00	$0	40,000
2019-01-09	Brege Laura	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	10,000	$0.00	$0	0
2019-01-09	Brege Laura	Dir	Open-market sell S	Common Stock	10,000	$20.00	$200,041	0
2019-01-09	Brege Laura	Dir	Exercise / conversion M	Common Stock	10,000	$2.16	$21,600	10,000
2018-11-30	BAKER BROS. ADVISORS LP	Dir	Other acquired transaction J · derivative	Common Stock Warrant (right to buy)	1,569	—	$16	1,569
2018-11-30	BAKER BROS. ADVISORS LP	Dir	Other disposed transaction J · derivative	Common Stock Warrant (right to buy)	10,731	—	$107	0
2018-11-30	BAKER BROS. ADVISORS LP	Dir	Other acquired transaction J	Common Stock	71,647	$0.00	$0	71,647
2018-11-30	BAKER BROS. ADVISORS LP	Dir	Other disposed transaction J	Common Stock	489,977	$0.00	$0	0
2018-11-30	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	11,178,823	$17.00	$190,039,991	35,976,940
2018-11-30	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	585,882	$17.00	$9,959,994	3,736,902
2018-11-19	Stankovic Srdjan R.	President	Equity grant / award A · derivative	Restricted Stock Units	25,000	$0.00	$0	25,000
2018-11-19	Stankovic Srdjan R.	President	Equity grant / award A · derivative	Employee Stock Options (Right to Buy)	150,000	$0.00	$0	150,000
2018-10-15	YOUNG TODD S.	EVP AND CFO	Equity grant / award A · derivative	Restricted Stock Units	4,688	$0.00	$0	4,688
2018-10-15	YOUNG TODD S.	EVP AND CFO	Equity grant / award A · derivative	Stock Option (right to buy)	18,750	$0.00	$0	18,750
2018-09-20	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	131,007	$19.09	$2,501,238	24,798,117
2018-09-20	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	14,555	$19.09	$277,890	3,151,020
2018-09-20	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	38,207	$19.01	$726,353	24,667,110
2018-09-20	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	4,245	$19.01	$80,702	3,136,465
2018-09-20	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	920,495	$18.64	$17,154,897	24,628,903
2018-09-20	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	102,267	$18.64	$1,905,909	3,132,220
2018-07-18	KIM AUSTIN D.	EVP AND GENERAL COUNSEL	Equity grant / award A · derivative	Stock Option (right to buy)	140,000	$0.00	$0	140,000
2018-06-06	SOLAND DANIEL B	—	Equity grant / award A · derivative	Stock Option (right to buy)	15,000	$0.00	$0	15,000
2018-04-18	Baity Glenn	EVP AND GC	Equity grant / award A · derivative	Stock Option (right to buy)	28,125	$0.00	$0	28,125
2018-03-02	SOLAND DANIEL B	—	Open-market buy P	Common Stock	3,000	$22.52	$67,560	10,000
2018-03-01	SOLAND DANIEL B	—	Open-market buy P	Common Stock	3,000	$24.09	$72,270	5,000
2018-03-01	SOLAND DANIEL B	—	Open-market buy P	Common Stock	2,000	$24.52	$49,040	7,000
2018-01-29	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	36,558	$32.39	$1,184,055	83,734
2018-01-10	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	50,179	$0.00	$0	0
2018-01-10	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	50,179	$2.18	$109,390	120,292
2018-01-02	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	74,321	$0.00	$0	0
2018-01-02	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	74,321	$30.14	$2,240,139	70,113
2018-01-02	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	74,321	$2.18	$162,020	144,434
2017-11-27	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M · derivative	Common Stock Warrant (right to buy)	39,378	—	$54,342	0
2017-11-27	BAKER BROS. ADVISORS LP	Dir	Other disposed transaction F	Common Stock	1,941	$28.00	$54,348	489,977
2017-11-27	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M	Common Stock	39,378	$1.38	$54,342	491,918
2017-10-13	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M · derivative	Common Stock Warrant (right to buy)	1,426,590	—	$1,968,694	0
2017-10-13	BAKER BROS. ADVISORS LP	Dir	Other disposed transaction F	Common Stock	55,457	$35.40	$1,963,178	23,708,408
2017-10-13	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M	Common Stock	1,426,590	$1.38	$1,968,694	23,763,865
2017-10-05	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	20,000	$0.00	$0	0
2017-10-05	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	7,500	$0.00	$0	0
2017-10-05	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	1,000	$0.00	$0	124,500
2017-10-05	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	37,500	$40.91	$1,534,042	69,656
2017-10-05	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	20,000	$2.00	$40,000	107,156
2017-10-05	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	7,500	$1.62	$12,150	99,656
2017-10-05	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	1,000	$2.18	$2,180	79,656
2017-10-04	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	4,500	$0.00	$0	125,500
2017-10-04	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	6,500	$0.00	$0	7,500
2017-10-04	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	4,500	$2.18	$9,810	78,656
2017-10-04	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	6,500	$1.62	$10,530	74,156
2017-09-07	YOUNG TODD S.	EVP AND CFO	Equity grant / award A · derivative	Stock Option (right to buy)	56,250	$0.00	$0	56,250
2017-08-30	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	16,507	$0.00	$0	14,000
2017-08-30	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	26,507	$34.87	$924,315	67,656
2017-08-30	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	16,507	$1.62	$26,741	94,163
2017-08-09	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	13,400	$0.00	$0	30,507
2017-08-09	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	922	$0.00	$0	0
2017-08-09	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	14,322	$34.88	$499,534	77,656
2017-08-09	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	13,400	$1.62	$21,708	91,978
2017-08-09	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	922	$1.55	$1,429	78,578
2017-08-04	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	6,500	$0.00	$0	43,907
2017-08-04	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	6,500	$1.62	$10,530	77,656
2017-07-20	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	28,097	$0.00	$0	28,000
2017-07-20	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	38,097	$30.00	$1,142,910	71,156
2017-07-20	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	28,097	$1.62	$45,517	109,253
2017-07-17	SOLAND DANIEL B	—	Equity grant / award A · derivative	Stock Option (right to buy)	15,000	$0.00	$0	15,000
2017-06-22	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	1,903	$0.00	$0	56,097
2017-06-22	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	1,903	$30.00	$57,091	81,156
2017-06-22	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	1,903	$1.62	$3,083	83,059
2017-06-13	SOLAND DANIEL B	—	Equity grant / award A · derivative	Stock Option (right to buy)	15,000	$0.00	$0	15,000
2017-05-15	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	14,093	$0.00	$0	58,000
2017-05-15	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	14,093	$1.62	$22,831	81,156
2017-03-29	YANG MICHAEL J.	EVP AND CCO	Equity grant / award A · derivative	Stock Option (right to buy)	400,000	$0.00	$0	400,000
2017-03-08	YOUNG TODD S.	EVP AND CFO	Equity grant / award A · derivative	Stock Option (right to buy)	37,500	$0.00	$0	37,500
2017-02-21	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M · derivative	Stock Option (right to buy)	7,856	$0.00	$0	82,500
2017-02-21	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Open-market sell S	Common Stock	7,856	$39.65	$311,490	1,671
2017-02-21	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M	Common Stock	7,856	$34.45	$270,639	9,527
2017-02-16	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M · derivative	Stock Option (right to buy)	29,644	$0.00	$0	90,356
2017-02-16	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M · derivative	Stock Option (right to buy)	19,687	$0.00	$0	13,125
2017-02-16	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M · derivative	Stock Option (right to buy)	17,421	$0.00	$0	36,102
2017-02-16	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Open-market sell S	Common Stock	66,752	$39.88	$2,662,116	1,671
2017-02-16	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M	Common Stock	29,644	$34.45	$1,021,236	68,423
2017-02-16	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M	Common Stock	19,687	$27.20	$535,486	38,779
2017-02-16	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M	Common Stock	17,421	$19.61	$341,626	19,092
2017-02-15	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M · derivative	Stock Option (right to buy)	1,700	$0.00	$0	53,523
2017-02-15	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Open-market sell S	Common Stock	1,700	$39.65	$67,405	1,671
2017-02-15	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M	Common Stock	1,700	$19.61	$33,337	3,371
2017-02-14	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M · derivative	Stock Option (right to buy)	74,381	$0.00	$0	55,223
2017-02-14	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M · derivative	Stock Option (right to buy)	12,747	$0.00	$0	7,649
2017-02-14	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Open-market sell S	Common Stock	89,088	$39.69	$3,535,573	1,671
2017-02-14	Moore Terrence O	EVP, CHIEF COMMERCIAL OFFICER	Exercise / conversion M	Common Stock	87,128	$19.61	$1,708,580	90,759
2017-02-01	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	21,078	$0.00	$0	0
2017-02-01	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	31,078	$35.15	$1,092,382	67,063
2017-02-01	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	21,078	$1.55	$32,671	98,141
2016-12-28	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	5,500	$0.00	$0	72,093
2016-12-28	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	5,500	$1.62	$8,910	77,063
2016-12-27	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	9,800	$0.00	$0	21,078
2016-12-27	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	9,800	$30.46	$298,474	71,563
2016-12-27	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	9,800	$1.55	$15,190	81,363
2016-12-20	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	10,000	$0.00	$0	30,878
2016-12-20	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	10,000	$30.00	$300,001	71,563
2016-12-20	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	10,000	$1.55	$15,500	81,563
2016-12-19	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	8,635	$0.00	$0	0
2016-12-19	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	8,635	$1.64	$14,161	71,563
2016-11-10	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	10,200	$0.00	$0	40,878
2016-11-10	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	10,200	$30.07	$306,687	62,921
2016-11-10	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	10,200	$1.55	$15,810	73,121
2016-08-22	YOUNG TODD S.	EVP AND CFO	Equity grant / award A · derivative	Stock Option (right to buy)	200,000	$0.00	$0	200,000
2016-08-16	HARRIGAN EDMUND	—	Open-market buy P	Common Stock	1,000	$32.97	$32,970	1,000
2016-08-10	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	1,169,877	$33.00	$38,605,941	22,337,275
2016-08-10	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	133,153	$33.00	$4,394,049	3,029,953
2016-07-12	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	2,625	$0.00	$0	0
2016-07-12	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	3,375	$0.00	$0	0
2016-07-12	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	645	$0.00	$0	0
2016-07-12	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	5,298	$0.00	$0	0
2016-07-12	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	11,943	$35.00	$418,031	62,921
2016-07-12	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	2,625	$6.78	$17,798	74,864
2016-07-12	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	3,375	$6.78	$22,882	72,239
2016-07-12	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	645	$6.78	$4,373	68,864
2016-07-12	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	5,298	$6.78	$35,920	68,219
2016-07-11	Baity Glenn	EVP AND GC	Exercise / conversion M · derivative	Stock Option (right to buy)	4,057	$0.00	$0	5,298
2016-07-11	Baity Glenn	EVP AND GC	Open-market sell S	Common Stock	4,057	$35.00	$142,001	62,921
2016-07-11	Baity Glenn	EVP AND GC	Exercise / conversion M	Common Stock	4,057	$6.78	$27,506	66,978
2016-06-10	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	26,500	$0.00	$0	26,500
2016-06-07	GRAY MARY ANN	—	Exercise / conversion M · derivative	Stock option (right to buy)	10,000	$0.00	$0	0
2016-06-07	GRAY MARY ANN	—	Exercise / conversion M · derivative	Stock option (right to buy)	6,637	$0.00	$0	0
2016-06-07	GRAY MARY ANN	—	Exercise / conversion M	Common Stock	10,000	$9.04	$90,400	149,476
2016-06-07	GRAY MARY ANN	—	Exercise / conversion M	Common Stock	6,637	$9.04	$59,998	139,476
2016-04-18	Iversen Leslie L	—	Exercise / conversion M · derivative	Stock option (right to buy)	33,697	$0.00	$0	0
2016-04-18	Iversen Leslie L	—	Open-market sell S	Common Stock	33,697	$33.53	$1,129,999	36,127
2016-04-18	Iversen Leslie L	—	Exercise / conversion M	Common Stock	33,697	$1.75	$58,970	69,824

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count