Financial Metrics

ALNY ALNYLAM PHARMACEUTICALS, INC.

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2020-06-30	-1.56	—	USD/shares	10-Q	2021-08-03
Quarterly	2020-09-30	-2.18	-39.7%	USD/shares	10-Q	2021-10-28
Quarterly	2021-03-31	-1.71	+21.6%	USD/shares	10-Q	2022-04-28
Quarterly	2021-06-30	-1.61	+5.8%	USD/shares	10-Q	2022-07-28
Quarterly	2021-09-30	-1.72	-6.8%	USD/shares	10-Q	2022-10-27
Quarterly	2022-03-31	-2.0	-16.3%	USD/shares	10-Q	2023-05-04
Quarterly	2022-06-30	-2.29	-14.5%	USD/shares	10-Q	2023-08-03
Quarterly	2022-09-30	-3.32	-45.0%	USD/shares	10-Q	2023-11-02
Quarterly	2023-03-31	-1.4	+57.8%	USD/shares	10-Q	2024-05-02
Quarterly	2023-06-30	-2.21	-57.9%	USD/shares	10-Q	2024-08-01
Quarterly	2023-09-30	1.15	+152.0%	USD/shares	10-Q	2024-10-31
Quarterly	2024-03-31	-0.52	-145.2%	USD/shares	10-Q	2025-05-01
Quarterly	2024-06-30	-0.13	+75.0%	USD/shares	10-Q	2025-07-31
Quarterly	2024-09-30	-0.87	-569.2%	USD/shares	10-Q	2025-10-30
Quarterly	2025-03-31	-0.44	+49.4%	USD/shares	10-Q	2025-05-01
Quarterly	2025-06-30	-0.51	-15.9%	USD/shares	10-Q	2025-07-31
Quarterly	2025-09-30	1.84	+460.8%	USD/shares	10-Q	2025-10-30
Annual	2019-12-31	-8.11	—	USD/shares	10-K	2022-02-10
Annual	2020-12-31	-7.46	+8.0%	USD/shares	10-K	2023-02-23
Annual	2021-12-31	-7.2	+3.5%	USD/shares	10-K	2024-02-15
Annual	2022-12-31	-9.3	-29.2%	USD/shares	10-K	2025-02-13
Annual	2023-12-31	-3.52	+62.2%	USD/shares	10-K	2026-02-12
Annual	2024-12-31	-2.18	+38.1%	USD/shares	10-K	2026-02-12
Annual	2025-12-31	2.33	+206.9%	USD/shares	10-K	2026-02-12

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2020-12-31	191278000.0	—	USD	10-Q	2021-10-28
Quarterly	2021-03-31	191590000.0	+0.2%	USD	10-Q	2021-04-29
Quarterly	2021-06-30	433151000.0	+126.1%	USD	10-Q	2021-08-03
Quarterly	2021-09-30	433799000.0	+0.1%	USD	10-Q	2021-10-28
Quarterly	2021-12-31	675697000.0	+55.8%	USD	10-Q	2022-07-28
Quarterly	2022-03-31	676710000.0	+0.1%	USD	10-Q	2022-04-28
Quarterly	2022-06-30	677723000.0	+0.1%	USD	10-Q	2022-07-28

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	2759000.0	—	USD	10-Q	2017-05-05
Quarterly	2016-06-30	24380000.0	+783.7%	USD	10-Q	2017-08-09
Quarterly	2016-09-30	44678000.0	+83.3%	USD	10-Q	2017-11-07
Quarterly	2017-03-31	36152000.0	-19.1%	USD	10-Q	2018-05-04
Quarterly	2017-06-30	57803000.0	+59.9%	USD	10-Q	2018-08-02
Quarterly	2017-09-30	83481000.0	+44.4%	USD	10-Q	2018-11-07
Quarterly	2018-03-31	21257000.0	-74.5%	USD	10-Q	2019-05-02
Quarterly	2018-06-30	43965000.0	+106.8%	USD	10-Q	2019-08-06
Quarterly	2018-09-30	89374000.0	+103.3%	USD	10-Q	2019-10-31
Quarterly	2019-03-31	44049000.0	-50.7%	USD	10-Q	2020-05-06
Quarterly	2019-06-30	65293000.0	+48.2%	USD	10-Q	2020-08-06
Quarterly	2019-09-30	101351000.0	+55.2%	USD	10-Q	2020-11-05
Quarterly	2020-03-31	19617000.0	-80.6%	USD	10-Q	2021-04-29
Quarterly	2020-06-30	36275000.0	+84.9%	USD	10-Q	2021-08-03
Quarterly	2020-09-30	48693000.0	+34.2%	USD	10-Q	2021-10-28
Quarterly	2021-03-31	17178000.0	-64.7%	USD	10-Q	2022-04-28
Quarterly	2021-06-30	28424000.0	+65.5%	USD	10-Q	2022-07-28
Quarterly	2021-09-30	54486000.0	+91.7%	USD	10-Q	2022-10-27
Quarterly	2022-03-31	17859000.0	-67.2%	USD	10-Q	2023-05-04
Quarterly	2022-06-30	33914000.0	+89.9%	USD	10-Q	2023-08-03
Quarterly	2022-09-30	50424000.0	+48.7%	USD	10-Q	2023-11-02
Quarterly	2023-03-31	13891000.0	-72.5%	USD	10-Q	2024-05-02
Quarterly	2023-06-30	29810000.0	+114.6%	USD	10-Q	2024-08-01
Quarterly	2023-09-30	46902000.0	+57.3%	USD	10-Q	2024-10-31
Quarterly	2024-03-31	12973000.0	-72.3%	USD	10-Q	2025-05-01
Quarterly	2024-06-30	20991000.0	+61.8%	USD	10-Q	2025-07-31
Quarterly	2024-09-30	25183000.0	+20.0%	USD	10-Q	2025-10-30
Quarterly	2025-03-31	8970000.0	-64.4%	USD	10-Q	2025-05-01
Quarterly	2025-06-30	23263000.0	+159.3%	USD	10-Q	2025-07-31
Quarterly	2025-09-30	35405000.0	+52.2%	USD	10-Q	2025-10-30
Annual	2016-12-31	64557000.0	—	USD	10-K	2019-02-14
Annual	2017-12-31	104209000.0	+61.4%	USD	10-K	2020-02-13
Annual	2018-12-31	126887000.0	+21.8%	USD	10-K	2021-02-11
Annual	2019-12-31	140156000.0	+10.5%	USD	10-K	2022-02-10
Annual	2020-12-31	70361000.0	-49.8%	USD	10-K	2023-02-23
Annual	2021-12-31	76372000.0	+8.5%	USD	10-K	2024-02-15
Annual	2022-12-31	72059000.0	-5.6%	USD	10-K	2025-02-13
Annual	2023-12-31	62211000.0	-13.7%	USD	10-K	2026-02-12
Annual	2024-12-31	34277000.0	-44.9%	USD	10-K	2026-02-12
Annual	2025-12-31	58697000.0	+71.2%	USD	10-K	2026-02-12

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	85277000.0	—	shares	10-Q	2017-05-05
Quarterly	2016-06-30	85545000.0	+0.3%	shares	10-Q	2017-08-09
Quarterly	2016-09-30	85716000.0	+0.2%	shares	10-Q	2017-11-07
Quarterly	2017-03-31	86027000.0	+0.4%	shares	10-Q	2018-05-04
Quarterly	2017-06-30	88098000.0	+2.4%	shares	10-Q	2018-08-02
Quarterly	2017-09-30	91828000.0	+4.2%	shares	10-Q	2018-11-07
Quarterly	2018-03-31	99979000.0	+8.9%	shares	10-Q	2019-05-02
Quarterly	2018-06-30	100519000.0	+0.5%	shares	10-Q	2019-08-06
Quarterly	2018-09-30	100783000.0	+0.3%	shares	10-Q	2019-10-31
Quarterly	2019-03-31	105400000.0	+4.6%	shares	10-Q	2020-05-06
Quarterly	2019-06-30	108576000.0	+3.0%	shares	10-Q	2020-08-06
Quarterly	2019-09-30	108701000.0	+0.1%	shares	10-Q	2020-11-05
Quarterly	2020-03-31	112748000.0	+3.7%	shares	10-Q	2021-04-29
Quarterly	2020-06-30	114911000.0	+1.9%	shares	10-Q	2021-08-03
Quarterly	2020-09-30	115986000.0	+0.9%	shares	10-Q	2021-10-28
Quarterly	2021-03-31	117080000.0	+0.9%	shares	10-Q	2022-04-28
Quarterly	2021-06-30	117772000.0	+0.6%	shares	10-Q	2022-07-28
Quarterly	2021-09-30	119141000.0	+1.2%	shares	10-Q	2022-10-27
Quarterly	2022-03-31	120393000.0	+1.1%	shares	10-Q	2023-05-04
Quarterly	2022-06-30	120896000.0	+0.4%	shares	10-Q	2023-08-03
Quarterly	2022-09-30	122166000.0	+1.1%	shares	10-Q	2023-11-02
Quarterly	2023-03-31	124111000.0	+1.6%	shares	10-Q	2024-05-02
Quarterly	2023-06-30	124659000.0	+0.4%	shares	10-Q	2024-08-01
Quarterly	2023-09-30	131337000.0	+5.4%	shares	10-Q	2024-10-31
Quarterly	2024-03-31	126138000.0	-4.0%	shares	10-Q	2025-05-01
Quarterly	2024-06-30	126733000.0	+0.5%	shares	10-Q	2025-07-31
Quarterly	2024-09-30	128590000.0	+1.5%	shares	10-Q	2025-10-30
Quarterly	2025-03-31	129676000.0	+0.8%	shares	10-Q	2025-05-01
Quarterly	2025-06-30	130628000.0	+0.7%	shares	10-Q	2025-07-31
Quarterly	2025-09-30	137348000.0	+5.1%	shares	10-Q	2025-10-30
Annual	2016-12-31	85596000.0	—	shares	10-K	2019-02-14
Annual	2017-12-31	90554000.0	+5.8%	shares	10-K	2020-02-13
Annual	2018-12-31	100590000.0	+11.1%	shares	10-K	2021-02-11
Annual	2019-12-31	109264000.0	+8.6%	shares	10-K	2022-02-10
Annual	2020-12-31	114986000.0	+5.2%	shares	10-K	2023-02-23
Annual	2021-12-31	118451000.0	+3.0%	shares	10-K	2024-02-15
Annual	2022-12-31	121689000.0	+2.7%	shares	10-K	2025-02-13
Annual	2023-12-31	124906000.0	+2.6%	shares	10-K	2026-02-12
Annual	2024-12-31	127651000.0	+2.2%	shares	10-K	2026-02-12
Annual	2025-12-31	134684000.0	+5.5%	shares	10-K	2026-02-12

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

N/A

Total Liabilities (latest annual)

4,177,155,000

Current Liabilities (latest annual)

1,466,349,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-0.0866	—	ratio	10-Q	2017-05-05
Quarterly	2016-06-30	-0.0820	+5.3%	ratio	10-Q	2017-08-09
Quarterly	2016-09-30	-0.1025	-25.0%	ratio	10-Q	2017-11-07
Quarterly	2017-03-31	-0.1291	-25.9%	ratio	10-Q	2018-05-04
Quarterly	2017-06-30	-0.2010	-55.7%	ratio	10-Q	2018-08-02
Quarterly	2017-09-30	-0.3293	-63.8%	ratio	10-Q	2018-11-07
Quarterly	2018-03-31	-0.0805	+75.6%	ratio	10-Q	2019-10-31
Quarterly	2018-06-30	-0.1009	-25.4%	ratio	10-Q	2019-10-31
Quarterly	2018-09-30	-0.3721	-268.8%	ratio	10-Q	2019-10-31
Quarterly	2019-03-31	-0.1176	+68.4%	ratio	10-Q	2020-11-05
Quarterly	2019-06-30	-0.1249	-6.2%	ratio	10-Q	2020-11-05
Quarterly	2019-09-30	-0.1298	-3.9%	ratio	10-Q	2020-11-05
Quarterly	2020-03-31	-0.1350	-4.0%	ratio	10-Q	2021-10-28
Quarterly	2020-06-30	-0.1280	+5.2%	ratio	10-Q	2021-10-28
Quarterly	2020-09-30	-0.2085	-62.8%	ratio	10-Q	2021-10-28
Quarterly	2021-03-31	-0.2163	-3.7%	ratio	10-Q	2022-10-27
Quarterly	2021-06-30	-0.2221	-2.7%	ratio	10-Q	2022-10-27
Quarterly	2021-09-30	-0.2706	-21.8%	ratio	10-Q	2022-10-27
Quarterly	2022-03-31	-0.5991	-121.4%	ratio	10-Q	2023-11-02
Quarterly	2022-06-30	-1.5758	-163.0%	ratio	10-Q	2023-11-02
Quarterly	2022-09-30	6.0014	+480.8%	ratio	10-Q	2023-11-02
Quarterly	2023-03-31	0.6716	-88.8%	ratio	10-Q	2024-10-31
Quarterly	2023-06-30	0.6763	+0.7%	ratio	10-Q	2024-10-31
Quarterly	2023-09-30	-0.8908	-231.7%	ratio	10-Q	2024-10-31
Quarterly	2024-03-31	0.3007	+133.8%	ratio	10-Q	2025-10-30
Quarterly	2024-06-30	5.5067	+1731.3%	ratio	10-Q	2025-10-30
Quarterly	2024-09-30	-3.4484	-162.6%	ratio	10-Q	2025-10-30
Quarterly	2025-03-31	-0.4979	+85.6%	ratio	10-Q	2025-10-30
Quarterly	2025-06-30	-0.2645	+46.9%	ratio	10-Q	2025-10-30
Quarterly	2025-09-30	1.0735	+505.9%	ratio	10-Q	2025-10-30
Annual	2016-12-31	-0.4457	—	ratio	10-K	2019-02-14
Annual	2017-12-31	-0.2779	+37.6%	ratio	10-K	2020-02-13
Annual	2018-12-31	-0.5849	-110.5%	ratio	10-K	2021-02-11
Annual	2019-12-31	-0.6159	-5.3%	ratio	10-K	2022-02-10
Annual	2020-12-31	-0.8446	-37.1%	ratio	10-K	2023-02-23
Annual	2021-12-31	-1.4499	-71.7%	ratio	10-K	2024-02-15
Annual	2022-12-31	7.1491	+593.1%	ratio	10-K	2025-02-13
Annual	2023-12-31	1.9953	-72.1%	ratio	10-K	2026-02-12
Annual	2024-12-31	-4.1462	-307.8%	ratio	10-K	2026-02-12
Annual	2025-12-31	0.3976	+109.6%	ratio	10-K	2026-02-12

8-K Material Event Details

59 filings · 114 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

972 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-04-06	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	199	$333.94	$66,454	9,443
2026-04-06	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	293	$331.89	$97,244	9,642
2026-04-06	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	829	$330.46	$273,951	9,935
2026-04-06	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	909	$329.76	$299,752	10,764
2026-04-06	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	56	$320.14	$17,928	11,673
2026-04-02	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	8	$325.49	$2,604	11,729
2026-04-02	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	81	$323.64	$26,215	11,737
2026-04-02	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	245	$322.86	$79,101	11,818
2026-04-02	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	224	$321.64	$72,047	12,063
2026-04-02	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	147	$320.62	$47,131	12,287
2026-04-02	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	86	$319.69	$27,493	12,434
2026-04-02	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	209	$318.47	$66,560	12,520
2026-04-02	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	359	$317.44	$113,961	12,729
2026-04-02	McLaughlin Melissa	Chief Human Resources Officer	Open-market sell S	Common Stock	265	$316.61	$83,902	13,088
2026-03-05	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	500	$326.08	$163,040	18,693
2026-03-05	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	510	$324.59	$165,541	19,193
2026-03-05	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	740	$323.55	$239,427	19,703
2026-03-05	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	654	$322.33	$210,804	20,443
2026-03-04	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	208	$325.67	$67,739	21,097
2026-03-04	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	272	$324.88	$88,367	21,305
2026-03-04	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	767	$323.84	$248,385	21,577
2026-03-04	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	350	$323.01	$113,054	22,344
2026-03-04	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	289	$321.82	$93,006	22,694
2026-03-04	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	215	$320.81	$68,974	22,983
2026-03-04	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	102	$320.01	$32,641	23,198
2026-03-04	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	106	$319.03	$33,817	23,300
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Equity grant / award A · derivative	Stock Option (right to buy)	10,480	$0.00	$0	10,480
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	53	$332.64	$17,630	64,273
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	129	$331.93	$42,819	64,326
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	112	$330.85	$37,055	64,455
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	234	$329.71	$77,152	64,567
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	138	$328.71	$45,362	64,801
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	454	$327.67	$148,762	64,939
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	541	$326.81	$176,804	65,393
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	356	$325.63	$115,924	65,934
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	124	$324.65	$40,257	66,290
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Open-market sell S	Common Stock	65	$323.62	$21,035	66,414
2026-03-02	Poulton Jeffrey V.	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	4,769	$0.00	$0	66,479
2026-02-27	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Restricted Stock Units	5,921	$0.00	$0	0
2026-02-27	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	5,921	$0.00	$0	91,583
2026-02-23	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Equity grant / award A	Common Stock	158	$0.00	$0	21,422
2026-02-13	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	2,242	$310.08	$695,201	24,848
2026-02-12	Garg Pushkal	EVP Chief R&D	Equity grant / award A	Common Stock	4,579	$0.00	$0	27,090
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	15	$377.82	$5,667	22,511
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	19	$375.65	$7,137	22,526
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	14	$374.44	$5,242	22,545
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	3	$372.46	$1,117	22,559
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	18	$370.87	$6,676	22,562
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	40	$369.48	$14,779	22,580
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	92	$368.62	$33,913	22,620
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	50	$366.41	$18,320	22,753
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	220	$365.56	$80,423	22,803
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	199	$364.83	$72,601	23,023
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	47	$363.55	$17,087	23,222
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	73	$362.38	$26,454	23,269
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	98	$361.45	$35,422	23,342
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	155	$360.22	$55,834	23,440
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	85	$359.14	$30,527	23,595
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	123	$358.18	$44,056	23,680
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	96	$357.17	$34,288	23,803
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	41	$367.40	$15,063	22,712
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	42	$355.16	$14,917	23,940
2026-01-12	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	39	$353.95	$13,804	23,982
2026-01-11	Garg Pushkal	EVP Chief R&D	Equity grant / award A	Common Stock	3,800	$0.00	$0	24,021
2026-01-05	Arbuckle Stuart A	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	3,279	$0.00	$0	3,279
2025-11-26	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	659	$0.00	$0	28,141
2025-11-26	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	839	$0.00	$0	0
2025-11-26	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	847	$0.00	$0	0
2025-11-26	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	2,352	$0.00	$0	0
2025-11-26	Greenstreet Yvonne	Chief Executive Officer	Other disposed transaction F	Common Stock	1,121	$445.12	$498,980	68,985
2025-11-26	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	659	$151.59	$99,898	70,106
2025-11-26	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	847	$118.05	$99,988	69,447
2025-11-26	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	2,352	$85.00	$199,920	68,600
2025-11-26	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	839	$119.13	$99,950	66,248
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Exercise / conversion M · derivative	Stock Option (right to buy)	8,161	$0.00	$0	839
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	295	$463.08	$136,609	21,264
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	323	$461.96	$149,213	21,559
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	707	$460.84	$325,814	21,882
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	622	$459.89	$286,052	22,589
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	794	$458.41	$363,978	23,211
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	262	$457.39	$119,836	24,005
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	364	$456.25	$166,075	24,267
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	368	$455.24	$167,528	24,631
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	129	$451.51	$58,245	24,999
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	96	$450.09	$43,209	25,128
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	8,168	$449.00	$3,667,432	25,224
2025-11-17	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Exercise / conversion M	Common Stock	8,161	$119.13	$972,220	33,392
2025-11-13	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Performance Stock Option 2017 (right to buy)	10,000	$0.00	$0	0
2025-11-13	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	261	$456.03	$119,024	65,409
2025-11-13	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	195	$454.69	$88,665	65,670
2025-11-13	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	881	$453.99	$399,965	65,865
2025-11-13	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	1,599	$452.85	$724,107	66,746
2025-11-13	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	1,702	$451.94	$769,202	68,345
2025-11-13	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	2,218	$450.69	$999,630	70,047
2025-11-13	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	1,477	$450.02	$664,680	72,265
2025-11-13	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	1,013	$448.76	$454,594	73,742
2025-11-13	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	654	$447.73	$292,815	74,755
2025-11-13	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$119.13	$1,191,300	75,409
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Performance Stock Option 2017 (right to buy)	15,000	$0.00	$0	10,000
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Performance Stock Option 2016 (right to buy)	650	$0.00	$0	0
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	430	$458.42	$197,121	65,409
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	604	$457.71	$276,457	65,839
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	2,420	$456.64	$1,105,069	66,443
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	3,406	$455.56	$1,551,637	68,863
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	1,960	$454.84	$891,486	72,269
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	1,069	$453.52	$484,813	74,229
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	1,210	$452.43	$547,440	75,298
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	1,255	$451.16	$566,206	76,508
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	453	$450.17	$203,927	77,763
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	2,132	$449.15	$957,588	78,216
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	711	$448.07	$318,578	80,348
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	15,000	$119.13	$1,786,950	81,059
2025-11-12	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	650	$42.22	$27,443	66,059
2025-10-01	SUPRAN BRYAN	EVP, CLO and Secretary	Equity grant / award A	Common Stock	13,026	$0.00	$0	13,026
2025-09-09	Reitan Colleen F	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	18,000	$0.00	$0	0
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	25	$480.98	$12,024	775
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	1,386	$479.55	$664,656	800
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	1,450	$478.67	$694,072	2,186
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	1,183	$477.47	$564,847	3,636
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	972	$476.31	$462,973	4,819
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	951	$474.85	$451,582	5,791
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	838	$474.22	$397,396	6,742
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	823	$472.82	$389,131	7,580
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	222	$471.25	$104,618	8,403
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	799	$464.36	$371,024	8,625
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	1,652	$463.00	$764,876	9,424
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	2,290	$461.92	$1,057,797	11,076
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	473	$460.71	$217,916	13,366
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	1,403	$459.73	$645,001	13,839
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	1,888	$458.86	$866,328	15,242
2025-09-09	Reitan Colleen F	Dir	Open-market sell S	Common Stock	1,645	$457.44	$752,489	17,130
2025-09-09	Reitan Colleen F	Dir	Exercise / conversion M	Common Stock	18,000	$100.65	$1,811,700	18,775
2025-08-29	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	144	$452.49	$65,159	25,992
2025-08-29	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	266	$451.52	$120,104	26,136
2025-08-29	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	681	$449.54	$306,137	26,402
2025-08-29	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,289	$448.05	$577,536	27,083
2025-08-29	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	899	$446.98	$401,835	28,372
2025-08-29	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	195	$445.53	$86,878	29,271
2025-08-19	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	45	$461.74	$20,778	20,221
2025-08-19	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	305	$461.01	$140,608	20,266
2025-08-19	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	260	$459.59	$119,493	20,571
2025-08-19	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	231	$458.27	$105,860	20,831
2025-08-19	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	338	$457.26	$154,554	21,062
2025-08-19	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	276	$455.41	$125,693	21,400
2025-08-18	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	12	$455.82	$5,470	21,676
2025-08-18	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	241	$454.84	$109,616	21,688
2025-08-18	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	543	$454.04	$246,544	21,929
2025-08-18	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	329	$452.96	$149,024	22,472
2025-08-18	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	103	$451.99	$46,555	22,801
2025-08-18	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	90	$449.92	$40,493	22,943
2025-08-18	Garg Pushkal	EVP Chief R&D	Open-market sell S	Common Stock	39	$450.92	$17,586	22,904
2025-08-18	BONNEY MICHAEL W	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	11,250	$0.00	$0	0
2025-08-18	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	11,250	$450.00	$5,062,500	16,804
2025-08-18	BONNEY MICHAEL W	Dir	Exercise / conversion M	Common Stock	11,250	$70.20	$789,750	28,054
2025-08-15	Garg Pushkal	EVP Chief R&D	Equity grant / award A	Common Stock	2,851	$0.00	$0	23,072
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	3,454	$0.00	$0	0
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	4,032	$0.00	$0	0
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	5,228	$0.00	$0	0
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	4,581	$0.00	$0	0
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	5,153	$0.00	$0	0
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	9,000	$0.00	$0	0
2025-08-14	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	641	$442.66	$283,745	911
2025-08-14	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	1,205	$441.88	$532,465	1,552
2025-08-14	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	1,238	$440.54	$545,389	2,757
2025-08-14	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	5,302	$439.27	$2,329,010	3,995
2025-08-14	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	2,086	$438.34	$914,377	9,297
2025-08-14	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	1,922	$437.56	$840,990	11,383
2025-08-14	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	5,358	$436.00	$2,336,088	13,305
2025-08-14	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	7,675	$435.40	$3,341,695	18,663
2025-08-14	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	2,098	$434.50	$911,581	26,338
2025-08-14	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	1,938	$432.94	$839,038	28,436
2025-08-14	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	1,985	$430.81	$855,158	30,374
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	3,454	$189.87	$655,811	32,359
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	4,032	$171.95	$693,302	28,905
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	5,228	$151.22	$790,578	24,873
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	4,581	$148.77	$681,515	19,645
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	5,153	$128.31	$661,181	15,064
2025-08-14	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	9,000	$72.01	$648,090	9,911
2025-07-01	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Equity grant / award A	Common Stock	7,763	$0.00	$0	21,264
2025-06-02	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	12,080	$0.00	$0	839
2025-06-02	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	7,217	$0.00	$0	847
2025-06-02	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	19,297	$306.00	$5,904,882	48,948
2025-06-02	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	7,217	$118.05	$851,967	68,245
2025-06-02	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	12,080	$119.13	$1,439,090	61,028
2025-05-30	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	12,081	$0.00	$0	12,919
2025-05-30	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	19,559	$0.00	$0	8,064
2025-05-30	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	6,171	$306.00	$1,888,326	48,948
2025-05-30	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	25,469	$304.00	$7,742,576	55,119
2025-05-30	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	19,559	$118.05	$2,308,940	80,588
2025-05-30	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	12,081	$119.13	$1,439,210	61,029
2025-05-16	Greenstreet Yvonne	Chief Executive Officer	Equity grant / award G	Common Stock	8,376	$0.00	$0	48,948
2025-05-15	BONNEY MICHAEL W	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	11,250	$0.00	$0	0
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	1,617	$283.83	$458,953	16,804
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	1,728	$282.81	$488,696	18,421
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	802	$282.03	$226,188	20,149
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	372	$281.10	$104,569	20,951
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	432	$280.03	$120,973	21,323
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	1,239	$278.01	$344,454	21,755
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	1,263	$277.16	$350,053	22,994
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	301	$275.63	$82,965	24,257
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	882	$273.75	$241,448	24,558
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	660	$273.16	$180,286	25,440
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	431	$271.68	$117,094	26,100
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	245	$269.79	$66,099	26,531
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	729	$268.56	$195,780	26,776
2025-05-15	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	549	$267.14	$146,660	27,505
2025-05-15	BONNEY MICHAEL W	Dir	Exercise / conversion M	Common Stock	11,250	$131.21	$1,476,112	28,054
2025-05-08	Reitan Colleen F	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	1,558	$0.00	$0	1,558
2025-05-08	Reitan Colleen F	Dir	Equity grant / award A	Common Stock	775	$0.00	$0	775
2025-05-08	Ausiello Dennis A	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	1,558	$0.00	$0	1,558
2025-05-08	Ausiello Dennis A	Dir	Equity grant / award A	Common Stock	775	$0.00	$0	911
2025-05-02	Greenstreet Yvonne	Chief Executive Officer	Equity grant / award G	Common Stock	41,311	$0.00	$0	57,324
2025-04-16	Reitan Colleen F	Dir	Open-market sell S	Common Stock	36	$232.86	$8,383	0
2025-03-24	Garg Pushkal	CMO & EVP Dev & Med Affairs	Exercise / conversion M · derivative	Stock Option (right to buy)	5,445	$0.00	$0	0
2025-03-24	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	5,445	$300.00	$1,633,500	20,221
2025-03-24	Garg Pushkal	CMO & EVP Dev & Med Affairs	Exercise / conversion M	Common Stock	5,445	$42.22	$229,888	25,666
2025-03-24	PYOTT DAVID E I	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	7,440	$0.00	$0	0
2025-03-24	PYOTT DAVID E I	Dir	Open-market sell S	Common Stock	7,440	$299.00	$2,224,560	136
2025-03-24	PYOTT DAVID E I	Dir	Exercise / conversion M	Common Stock	7,440	$88.95	$661,788	7,576
2025-03-21	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	4,321	$285.00	$1,231,485	20,221
2025-03-13	SCHULMAN AMY W	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	2,750	$0.00	$0	0
2025-03-13	SCHULMAN AMY W	Dir	Exercise / conversion M	Common Stock	2,750	$131.21	$360,828	11,186
2025-03-03	Hesslein Robert W.	EVP, CLO and Secretary	Equity grant / award A · derivative	Stock Option (right to buy)	1,529	$0.00	$0	1,529
2025-03-03	Hesslein Robert W.	EVP, CLO and Secretary	Equity grant / award A	Common Stock	757	$0.00	$0	8,002
2025-02-28	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	214	$244.11	$52,240	84,547
2025-02-28	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	440	$243.23	$107,021	84,761
2025-02-28	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	1,093	$242.44	$264,987	85,201
2025-02-28	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	461	$241.51	$111,336	86,294
2025-02-28	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	284	$240.32	$68,251	86,755
2025-02-28	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	127	$239.18	$30,376	87,039
2025-02-28	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	123	$238.33	$29,315	87,166
2025-02-28	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	158	$236.51	$37,369	87,289
2025-02-28	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	37	$244.11	$9,032	12,385
2025-02-28	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	75	$243.23	$18,242	12,422
2025-02-28	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	187	$242.44	$45,336	12,497
2025-02-28	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	79	$241.51	$19,079	12,684
2025-02-28	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	48	$240.32	$11,535	12,763
2025-02-28	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	22	$239.18	$5,262	12,811
2025-02-28	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	21	$238.33	$5,005	12,833
2025-02-28	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	27	$236.51	$6,386	12,854
2025-02-27	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Restricted Stock Units	5,921	$0.00	$0	5,921
2025-02-27	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	5,921	$0.00	$0	87,447
2025-02-14	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	25	$264.87	$6,622	81,526
2025-02-14	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	38	$260.57	$9,902	81,619
2025-02-14	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	21	$263.33	$5,530	81,551
2025-02-14	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	59	$258.07	$15,226	81,678
2025-02-14	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	47	$261.45	$12,288	81,572
2025-02-14	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	98	$256.29	$25,116	81,784
2025-02-14	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	85	$255.56	$21,723	81,882
2025-02-14	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	201	$254.35	$51,124	81,967
2025-02-14	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	300	$253.37	$76,011	82,168
2025-02-14	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	271	$252.50	$68,428	82,468
2025-02-13	Greenstreet Yvonne	Chief Executive Officer	Equity grant / award A	Common Stock	3,859	$0.00	$0	82,739
2025-01-27	Garg Pushkal	CMO & EVP Dev & Med Affairs	Exercise / conversion M · derivative	Stock Option (right to buy)	23,876	$0.00	$0	0
2025-01-27	Garg Pushkal	CMO & EVP Dev & Med Affairs	Exercise / conversion M · derivative	Performance Stock Option 2015 (right to buy)	25,000	$0.00	$0	0
2025-01-27	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	52,592	$285.00	$14,988,720	11,989
2025-01-27	Garg Pushkal	CMO & EVP Dev & Med Affairs	Exercise / conversion M	Common Stock	25,000	$88.95	$2,223,750	64,581
2025-01-27	Garg Pushkal	CMO & EVP Dev & Med Affairs	Exercise / conversion M	Common Stock	23,876	$88.95	$2,123,770	39,581
2025-01-23	SHARP PHILLIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	11,250	$0.00	$0	0
2025-01-23	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	11,250	$275.00	$3,093,750	0
2025-01-23	SHARP PHILLIP A	Dir	Exercise / conversion M	Common Stock	11,250	$131.21	$1,476,112	11,250
2024-12-12	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	1	$255.80	$256	15,705
2024-12-12	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	140	$254.37	$35,612	15,706
2024-12-12	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	100	$252.94	$25,294	15,846
2024-12-12	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	778	$251.68	$195,807	15,946
2024-12-12	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	426	$250.08	$106,534	16,724
2024-12-12	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	186	$248.99	$46,312	17,150
2024-12-12	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	121	$247.48	$29,945	17,336
2024-11-26	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	300	$252.27	$75,681	78,880
2024-11-26	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	2,933	$251.42	$737,415	79,180
2024-11-26	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	1,131	$250.68	$283,519	82,113
2024-11-26	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	762	$249.60	$190,195	83,244
2024-11-26	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	93	$247.77	$23,043	84,006
2024-11-25	Greenstreet Yvonne	Chief Executive Officer	Equity grant / award A	Common Stock	10,658	$0.00	$0	84,099
2024-10-17	Reitan Colleen F	Dir	Open-market buy P	Common Stock	4	$302.67	$1,211	36
2024-10-08	Garg Pushkal	CMO & EVP Dev & Med Affairs	Equity grant / award A	Common Stock	96	$0.00	$0	15,705
2024-10-01	Hesslein Robert W.	EVP, CLO and Secretary	Equity grant / award A	Common Stock	7,245	$0.00	$0	7,245
2024-08-29	Reitan Colleen F	Dir	Open-market buy P	Common Stock	32	$286.00	$9,152	32
2024-08-20	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	2,352
2024-08-20	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	15,000	$280.00	$4,200,000	73,441
2024-08-20	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	15,000	$85.00	$1,275,000	88,441
2024-08-12	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Exercise / conversion M · derivative	Stock Option (right to buy)	6,667	$0.00	$0	0
2024-08-12	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Exercise / conversion M · derivative	Stock Option (right to buy)	14,058	$0.00	$0	2,192
2024-08-12	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	135	$274.65	$37,078	12,881
2024-08-12	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	1,158	$273.73	$316,979	13,016
2024-08-12	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	3,913	$272.43	$1,066,019	14,174
2024-08-12	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	5,736	$271.32	$1,556,292	18,087
2024-08-12	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	9,662	$270.17	$2,610,383	23,823
2024-08-12	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Open-market sell S	Common Stock	1,421	$268.66	$381,766	33,485
2024-08-12	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Exercise / conversion M	Common Stock	14,058	$85.00	$1,194,930	34,906
2024-08-12	Fitzgerald Kevin Joseph	CSO & EVP, Head of Research	Exercise / conversion M	Common Stock	6,667	$97.72	$651,499	20,848
2024-08-06	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	11,250	$0.00	$0	0
2024-08-06	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	9,000	$0.00	$0	0
2024-08-06	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	262	$266.45	$69,810	136
2024-08-06	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	632	$264.95	$167,448	398
2024-08-06	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	3,408	$263.72	$898,758	1,030
2024-08-06	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	4,367	$262.79	$1,147,604	4,438
2024-08-06	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	6,212	$261.63	$1,625,246	8,805
2024-08-06	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	3,742	$260.40	$974,417	15,017
2024-08-06	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	1,627	$259.56	$422,304	18,759
2024-08-06	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	9,000	$105.26	$947,340	20,386
2024-08-06	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	11,250	$131.21	$1,476,112	11,386
2024-08-01	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	15,148	$0.00	$0	17,352
2024-08-01	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	15,148	$270.00	$4,089,960	73,441
2024-08-01	Greenstreet Yvonne	Chief Executive Officer	Exercise / conversion M	Common Stock	15,148	$85.00	$1,287,580	88,589
2024-07-11	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	7,093	$261.00	$1,851,273	73,441
2024-06-25	SCHULMAN AMY W	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	8,500	$0.00	$0	2,750
2024-06-25	SCHULMAN AMY W	Dir	Open-market sell S	Common Stock	8,500	$240.00	$2,040,000	8,436
2024-06-25	SCHULMAN AMY W	Dir	Exercise / conversion M	Common Stock	8,500	$131.21	$1,115,285	16,936
2024-06-24	PYOTT DAVID E I	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	17,560	$0.00	$0	7,440
2024-06-24	PYOTT DAVID E I	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	7,470	$0.00	$0	3,780
2024-06-24	PYOTT DAVID E I	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	7,420	$0.00	$0	3,830
2024-06-24	PYOTT DAVID E I	Dir	Open-market sell S	Common Stock	7,470	$222.00	$1,658,340	136
2024-06-24	PYOTT DAVID E I	Dir	Open-market sell S	Common Stock	7,420	$221.00	$1,639,820	7,606
2024-06-24	PYOTT DAVID E I	Dir	Open-market sell S	Common Stock	17,560	$220.00	$3,863,200	15,026
2024-06-24	PYOTT DAVID E I	Dir	Exercise / conversion M	Common Stock	7,470	$71.99	$537,765	32,586
2024-06-24	PYOTT DAVID E I	Dir	Exercise / conversion M	Common Stock	7,420	$70.20	$520,884	25,116
2024-06-24	PYOTT DAVID E I	Dir	Exercise / conversion M	Common Stock	17,560	$88.95	$1,561,962	17,696
2024-05-29	SCHULMAN AMY W	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	30,000	$0.00	$0	0
2024-05-29	SCHULMAN AMY W	Dir	Open-market sell S	Common Stock	63	$149.76	$9,435	8,436
2024-05-29	SCHULMAN AMY W	Dir	Open-market sell S	Common Stock	11,516	$148.93	$1,715,078	8,499
2024-05-29	SCHULMAN AMY W	Dir	Open-market sell S	Common Stock	10,121	$148.21	$1,500,033	20,015
2024-05-29	SCHULMAN AMY W	Dir	Exercise / conversion M	Common Stock	30,000	$66.83	$2,004,900	30,136
2024-05-16	PYOTT DAVID E I	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	5,228	$0.00	$0	5,228
2024-03-01	Tanguler Tolga	EVP, Chief Commercial Officer	Equity grant / award A · derivative	Stock Option (right to buy)	9,279	$0.00	$0	9,279
2024-03-01	Tanguler Tolga	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	4,751	$0.00	$0	9,987
2024-02-29	SHARP PHILLIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	30,000	$0.00	$0	0
2024-02-29	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	516	$156.54	$80,775	0
2024-02-29	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	101	$154.07	$15,561	516
2024-02-29	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	1,906	$153.62	$292,800	617
2024-02-29	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	915	$152.40	$139,446	2,523
2024-02-29	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	13,557	$151.43	$2,052,937	3,438
2024-02-29	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	13,005	$150.60	$1,958,553	16,995
2024-02-29	SHARP PHILLIP A	Dir	Exercise / conversion M	Common Stock	30,000	$59.25	$1,777,500	30,000
2024-02-28	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1	$158.09	$158	5,236
2024-02-28	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	14	$157.30	$2,202	5,237
2024-02-28	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	100	$156.38	$15,638	5,251
2024-02-28	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	170	$155.45	$26,426	5,351
2024-02-28	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	216	$154.54	$33,381	5,521
2024-02-27	Tanguler Tolga	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Restricted Stock Units	1,667	$0.00	$0	3,333
2024-02-27	Tanguler Tolga	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	1,667	$0.00	$0	5,737
2024-02-16	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	156	$149.03	$23,249	7,332
2024-02-16	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	672	$148.24	$99,617	7,488
2024-02-16	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	480	$147.50	$70,800	8,160
2024-02-15	Garg Pushkal	CMO & EVP Dev & Med Affairs	Equity grant / award A	Common Stock	4,295	$0.00	$0	8,640
2024-02-02	Franchini Indrani Lall	EVP, CLO & Secretary	Open-market sell S	Common Stock	269	$172.38	$46,370	3,584
2024-02-02	Franchini Indrani Lall	EVP, CLO & Secretary	Open-market sell S	Common Stock	820	$171.14	$140,335	3,853
2024-02-02	Franchini Indrani Lall	EVP, CLO & Secretary	Open-market sell S	Common Stock	502	$170.01	$85,345	4,673
2024-02-01	Franchini Indrani Lall	EVP, CLO & Secretary	Exercise / conversion M · derivative	Restricted Stock Units	5,175	$0.00	$0	5,175
2024-02-01	Franchini Indrani Lall	EVP, CLO & Secretary	Exercise / conversion M	Common Stock	5,175	$0.00	$0	5,175
2023-12-27	BONNEY MICHAEL W	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	30,000	$0.00	$0	0
2023-12-27	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	30,000	$195.00	$5,850,000	16,029
2023-12-27	BONNEY MICHAEL W	Dir	Exercise / conversion M	Common Stock	30,000	$96.45	$2,893,500	46,029
2023-08-07	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	240	$185.32	$44,477	4,345
2023-08-07	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	814	$184.65	$150,305	4,585
2023-08-07	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	3,112	$183.58	$571,301	5,399
2023-08-04	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	164	$189.31	$31,047	8,511
2023-08-04	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	15	$188.40	$2,826	8,675
2023-08-04	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	86	$187.37	$16,114	8,690
2023-08-04	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	945	$186.39	$176,139	8,776
2023-08-04	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	1,593	$185.54	$295,565	9,721
2023-08-04	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	658	$184.70	$121,533	11,314
2023-08-03	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	450	$187.71	$84,470	16,029
2023-08-03	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	1,389	$187.04	$259,799	16,479
2023-08-03	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	1,714	$185.99	$318,787	17,868
2023-08-03	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	1,535	$184.89	$283,806	19,582
2023-08-03	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	560	$183.75	$102,900	21,117
2023-08-03	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	500	$182.45	$91,225	21,677
2023-08-03	BONNEY MICHAEL W	Dir	Open-market sell S	Common Stock	300	$181.08	$54,324	22,177
2023-08-03	Garg Pushkal	CMO & EVP Dev & Med Affairs	Equity grant / award A	Common Stock	3,109	$0.00	$0	11,972
2023-08-03	Garg Pushkal	CMO & EVP Dev & Med Affairs	Equity grant / award A	Common Stock	4,518	$0.00	$0	8,863
2023-08-02	BONNEY MICHAEL W	Dir	Exercise / conversion M · derivative	Restricted Stock Units	22,477	$0.00	$0	0
2023-08-02	BONNEY MICHAEL W	Dir	Exercise / conversion M	Common Stock	22,477	$0.00	$0	22,477
2023-05-18	PYOTT DAVID E I	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	3,454	$0.00	$0	3,454
2023-04-27	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	533	$197.08	$105,044	30,332
2023-04-27	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	331	$195.65	$64,760	30,865
2023-04-27	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	3,225	$194.94	$628,682	31,196
2023-04-27	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	2,898	$193.93	$562,009	34,421
2023-04-27	Greenstreet Yvonne	Chief Executive Officer	Open-market sell S	Common Stock	628	$193.18	$121,317	37,319
2023-04-26	Greenstreet Yvonne	Chief Executive Officer	Equity grant / award A	Common Stock	16,952	$0.00	$0	37,947
2023-04-06	Franchini Indrani Lall	EVP, CLO & Secretary	Open-market sell S	Common Stock	3,500	$210.00	$735,000	0
2023-03-07	KELLOGG PETER N	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	4,948	$0.00	$0	4,948
2023-03-03	Garg Pushkal	CMO & EVP Dev & Med Affairs	Exercise / conversion M · derivative	Stock Option (right to buy)	2,500	$0.00	$0	0
2023-03-03	Garg Pushkal	CMO & EVP Dev & Med Affairs	Exercise / conversion M · derivative	Performance Stock Option 2014 (right to buy)	2,500	$0.00	$0	0
2023-03-03	Garg Pushkal	CMO & EVP Dev & Med Affairs	Open-market sell S	Common Stock	18,072	$200.00	$3,614,400	4,345
2023-03-03	Garg Pushkal	CMO & EVP Dev & Med Affairs	Exercise / conversion M	Common Stock	2,500	$96.45	$241,125	22,417
2023-02-27	Greenstreet Yvonne	Chief Executive Officer	Equity grant / award A · derivative	Stock Option (right to buy)	36,775	$0.00	$0	36,775
2023-02-27	Greenstreet Yvonne	Chief Executive Officer	Equity grant / award A · derivative	Restricted Stock Units	17,763	$0.00	$0	17,763
2023-02-23	SCHULMAN AMY W	Dir	Exercise / conversion M · derivative	Restricted Stock Units	136	$0.00	$0	0
2023-02-23	SCHULMAN AMY W	Dir	Exercise / conversion M	Common Stock	136	$0.00	$0	136
2023-02-10	Vaishnaw Akshay	President	Exercise / conversion M · derivative	Stock Option (right to buy)	30,913	$0.00	$0	0
2023-02-10	Vaishnaw Akshay	President	Open-market sell S	Common Stock	4,302	$217.05	$933,749	14,970
2023-02-10	Vaishnaw Akshay	President	Open-market sell S	Common Stock	19,447	$216.38	$4,207,942	19,272
2023-02-10	Vaishnaw Akshay	President	Open-market sell S	Common Stock	10,279	$215.59	$2,216,050	38,719
2023-02-10	Vaishnaw Akshay	President	Open-market sell S	Common Stock	2,307	$214.28	$494,344	48,998
2023-02-10	Vaishnaw Akshay	President	Open-market sell S	Common Stock	1,709	$213.13	$364,239	51,305
2023-02-10	Vaishnaw Akshay	President	Exercise / conversion M	Common Stock	30,913	$63.00	$1,947,519	53,014
2023-02-02	Franchini Indrani Lall	EVP, CLO & Secretary	Open-market sell S	Common Stock	5	$227.38	$1,137	3,500
2023-02-02	Franchini Indrani Lall	EVP, CLO & Secretary	Open-market sell S	Common Stock	586	$226.62	$132,799	3,505
2023-02-02	Franchini Indrani Lall	EVP, CLO & Secretary	Open-market sell S	Common Stock	1,007	$225.80	$227,381	4,091
2023-02-02	Franchini Indrani Lall	EVP, CLO & Secretary	Open-market sell S	Common Stock	77	$223.97	$17,246	5,098
2023-02-01	Franchini Indrani Lall	EVP, CLO & Secretary	Exercise / conversion M · derivative	Restricted Stock Units	5,175	$0.00	$0	10,350
2023-02-01	Franchini Indrani Lall	EVP, CLO & Secretary	Exercise / conversion M	Common Stock	5,175	$0.00	$0	5,175
2023-01-05	Bertozzi Carolyn R	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	4,268	$0.00	$0	4,268
2022-12-05	Vaishnaw Akshay	President	Exercise / conversion M · derivative	Stock Option (right to buy)	1,124	$0.00	$0	28,876
2022-12-05	Vaishnaw Akshay	President	Exercise / conversion M · derivative	Stock Option (right to buy)	1,587	$0.00	$0	30,913
2022-12-05	Vaishnaw Akshay	President	Exercise / conversion M · derivative	Stock Option (right to buy)	2,368	$0.00	$0	0
2022-12-05	Vaishnaw Akshay	President	Other disposed transaction F	Common Stock	1,324	$226.20	$299,489	22,101
2022-12-05	Vaishnaw Akshay	President	Exercise / conversion M	Common Stock	2,368	$42.22	$99,977	23,425
2022-12-05	Vaishnaw Akshay	President	Exercise / conversion M	Common Stock	1,587	$63.00	$99,981	21,057
2022-12-05	Vaishnaw Akshay	President	Exercise / conversion M	Common Stock	1,124	$88.95	$99,980	19,470
2022-11-21	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	11,250	$0.00	$0	0
2022-11-21	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	22,500	$220.00	$4,950,000	0
2022-11-21	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	11,250	$71.99	$809,888	22,500
2022-08-22	Sigal Charles Elliott	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	4,456	$0.00	$0	4,456
2022-08-15	SHARP PHILLIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	30,000	$0.00	$0	0
2022-08-15	SHARP PHILLIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	3,670	$0.00	$0	0
2022-08-15	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	715	$232.81	$166,459	0
2022-08-15	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	3,853	$231.65	$892,547	715
2022-08-15	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	16,186	$230.71	$3,734,272	4,568
2022-08-15	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	11,600	$229.93	$2,667,188	20,754
2022-08-15	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	1,218	$228.33	$278,106	32,354
2022-08-15	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	98	$226.16	$22,164	33,572
2022-08-15	SHARP PHILLIP A	Dir	Exercise / conversion M	Common Stock	3,670	$63.86	$234,366	33,670
2022-08-15	SHARP PHILLIP A	Dir	Exercise / conversion M	Common Stock	30,000	$30.09	$902,700	30,000
2022-08-05	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	104	$225.15	$23,416	0
2022-08-05	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	5	$224.00	$1,120	104
2022-08-05	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	105	$220.95	$23,200	109
2022-08-05	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	99	$219.53	$21,733	214
2022-08-05	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	541	$218.71	$118,322	313
2022-08-05	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	440	$217.61	$95,748	854
2022-08-05	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	398	$216.21	$86,052	1,294
2022-08-05	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	149	$215.03	$32,039	1,692
2022-08-04	Tanguler Tolga	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	170	$210.50	$35,785	1,841
2022-08-04	Tanguler Tolga	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	1,618	$189.76	$307,032	2,011
2022-08-03	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,754	$210.00	$368,340	3,629
2022-08-03	Tanguler Tolga	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	3,629	$0.00	$0	5,383
2022-07-05	Tanguler Tolga	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,754	$150.00	$263,100	1,754
2022-05-18	PYOTT DAVID E I	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	5,153	$0.00	$0	5,153
2022-04-01	PAUL STEVEN M	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	15,000	$0.00	$0	0
2022-04-01	PAUL STEVEN M	Dir	Open-market sell S	Common Stock	175	$178.60	$31,255	1,000
2022-04-01	PAUL STEVEN M	Dir	Open-market sell S	Common Stock	825	$177.58	$146,504	1,175
2022-04-01	PAUL STEVEN M	Dir	Open-market sell S	Common Stock	526	$176.51	$92,844	2,000
2022-04-01	PAUL STEVEN M	Dir	Open-market sell S	Common Stock	90	$174.33	$15,690	2,526
2022-04-01	PAUL STEVEN M	Dir	Open-market sell S	Common Stock	642	$173.06	$111,105	2,616
2022-04-01	PAUL STEVEN M	Dir	Open-market sell S	Common Stock	1,434	$172.10	$246,791	3,258
2022-04-01	PAUL STEVEN M	Dir	Open-market sell S	Common Stock	1,235	$171.16	$211,383	4,692
2022-04-01	PAUL STEVEN M	Dir	Open-market sell S	Common Stock	4,872	$169.71	$826,827	5,927
2022-04-01	PAUL STEVEN M	Dir	Open-market sell S	Common Stock	4,948	$168.95	$835,965	10,799
2022-04-01	PAUL STEVEN M	Dir	Open-market sell S	Common Stock	253	$166.04	$42,008	15,747
2022-04-01	PAUL STEVEN M	Dir	Exercise / conversion M	Common Stock	15,000	$11.33	$169,950	16,000
2022-02-23	Garg Pushkal	CMO & EVP Dev & Med Affairs	Equity grant / award A · derivative	Stock Option (right to buy)	24,128	$0.00	$0	24,128
2022-02-09	SHARP PHILLIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	30,000	$0.00	$0	0
2022-02-09	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	30,000	$150.00	$4,500,000	0
2022-02-09	SHARP PHILLIP A	Dir	Exercise / conversion M	Common Stock	30,000	$11.33	$339,900	30,000
2022-02-01	Franchini Indrani Lall	EVP, CLO & Secretary	Equity grant / award A · derivative	Stock Option (right to buy)	29,182	$0.00	$0	29,182
2022-02-01	Franchini Indrani Lall	EVP, CLO & Secretary	Equity grant / award A · derivative	Restricted Stock Units	15,525	$0.00	$0	15,525
2021-12-31	Greenstreet Yvonne	Chief Executive Officer	Equity grant / award A · derivative	Stock Option (right to buy)	55,949	$0.00	$0	55,949
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	303	$195.11	$59,118	11,215
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	145	$193.67	$28,082	11,518
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	126	$193.37	$24,365	11,663
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	1,000	$191.45	$191,450	11,862
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	125	$190.86	$23,858	12,862
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	142	$190.39	$27,035	12,987
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	5	$190.27	$951	13,202
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	144	$190.02	$27,363	13,207
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	8	$189.18	$1,513	13,495
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	73	$192.25	$14,034	11,789
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	127	$188.26	$23,909	13,576
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	130	$187.35	$24,356	13,703
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	137	$187.08	$25,630	13,833
2021-12-23	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	124	$186.22	$23,091	13,970
2021-12-22	Vaishnaw Akshay	President, R&D	Other disposed transaction F	Common Stock	122	$186.48	$22,751	14,094
2021-12-22	Vaishnaw Akshay	President, R&D	Other disposed transaction F	Common Stock	1	$190.50	$190	14,216
2021-12-22	Vaishnaw Akshay	President, R&D	Other disposed transaction F	Common Stock	2,415	$189.13	$456,749	14,217
2021-12-21	Vaishnaw Akshay	President, R&D	Equity grant / award A	Common Stock	5,417	$0.00	$0	16,632
2021-12-10	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	839	$0.00	$0	51,661
2021-12-10	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,036	$0.00	$0	73,964
2021-12-10	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,124	$0.00	$0	63,876
2021-12-10	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	2,368	$0.00	$0	22,632
2021-12-10	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	2,368	$42.22	$99,977	220,132
2021-12-10	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	839	$119.13	$99,950	217,764
2021-12-10	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	1,124	$88.95	$99,980	216,925
2021-12-10	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	1,036	$96.45	$99,922	215,801
2021-11-12	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	33,978	$0.00	$0	0
2021-11-12	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	670	$174.34	$116,808	214,765
2021-11-12	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	683	$173.25	$118,330	215,435
2021-11-12	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	14,518	$172.22	$2,500,290	216,118
2021-11-12	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	7,742	$171.35	$1,326,592	230,636
2021-11-12	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	10,365	$170.36	$1,765,781	238,378
2021-11-12	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	33,978	$7.10	$241,244	248,743
2021-10-27	SCHULMAN AMY W	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	1,814	$0.00	$0	1,814
2021-08-13	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	33,979	$0.00	$0	33,978
2021-08-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	214	$201.55	$43,132	214,765
2021-08-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	3,828	$200.84	$768,816	214,979
2021-08-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	23,336	$199.92	$4,665,333	218,807
2021-08-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	4,160	$198.93	$827,549	242,143
2021-08-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	2,441	$198.02	$483,367	246,303
2021-08-13	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	33,979	$7.10	$241,251	248,744
2021-08-09	Vaishnaw Akshay	President, R&D	Exercise / conversion M · derivative	Performance Stock Option 2013 (right to buy)	10,834	$0.00	$0	10,832
2021-08-09	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	10,834	$200.00	$2,166,800	11,215
2021-08-09	Vaishnaw Akshay	President, R&D	Exercise / conversion M	Common Stock	10,834	$63.00	$682,542	22,049
2021-08-06	Greenstreet Yvonne	President & COO	Exercise / conversion M · derivative	Stock Option (right to buy)	28,064	$0.00	$0	0
2021-08-06	Greenstreet Yvonne	President & COO	Exercise / conversion M · derivative	Performance Stock Option 2016 (right to buy)	25,000	$0.00	$0	0
2021-08-06	Greenstreet Yvonne	President & COO	Open-market sell S	Common Stock	53,064	$199.00	$10,559,736	11,023
2021-08-06	Greenstreet Yvonne	President & COO	Exercise / conversion M	Common Stock	25,000	$77.10	$1,927,500	64,087
2021-08-06	Greenstreet Yvonne	President & COO	Exercise / conversion M	Common Stock	28,064	$77.10	$2,163,734	39,087
2021-08-05	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	7,876	$0.00	$0	1,124
2021-08-05	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Performance Stock Option 2015 (right to buy)	2,124	$0.00	$0	11,876
2021-08-05	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	10,000	$188.95	$1,889,500	5,132
2021-08-05	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,124	$88.95	$188,930	15,132
2021-08-05	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	7,876	$88.95	$700,570	13,008
2021-08-02	BONNEY MICHAEL W	Executive Chair	Equity grant / award A · derivative	Restricted Stock Units	22,477	$0.00	$0	22,477
2021-07-15	PYOTT DAVID E I	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	4,032	$0.00	$0	4,032
2021-07-12	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	5,000	$0.00	$0	9,000
2021-07-12	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,812	$0.00	$0	17,188
2021-07-12	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	5,000	$178.95	$894,750	5,132
2021-07-12	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,812	$179.00	$324,348	10,132
2021-07-12	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	5,000	$88.95	$444,750	11,944
2021-07-12	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	1,812	$85.00	$154,020	6,944
2021-06-18	Vaishnaw Akshay	President, R&D	Exercise / conversion M · derivative	Stock Option (right to buy)	970	$0.00	$0	2,368
2021-06-18	Vaishnaw Akshay	President, R&D	Exercise / conversion M · derivative	Performance Stock Option 2013 (right to buy)	10,834	$0.00	$0	21,666
2021-06-18	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	14,708	$175.00	$2,573,900	11,215
2021-06-18	Vaishnaw Akshay	President, R&D	Exercise / conversion M	Common Stock	970	$42.22	$40,953	25,923
2021-06-18	Vaishnaw Akshay	President, R&D	Exercise / conversion M	Common Stock	10,834	$63.00	$682,542	24,953
2021-06-09	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,734	$154.00	$267,036	5,132
2021-05-13	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	33,979	$0.00	$0	67,957
2021-05-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	1,023	$134.37	$137,461	214,765
2021-05-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	1,624	$133.56	$216,901	215,788
2021-05-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	3,481	$132.32	$460,606	217,412
2021-05-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	11,203	$131.18	$1,469,610	220,893
2021-05-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	9,121	$130.34	$1,188,831	232,096
2021-05-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	4,512	$129.32	$583,492	241,217
2021-05-13	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	3,015	$128.30	$386,824	245,729
2021-05-13	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	33,979	$7.10	$241,251	248,744
2021-04-21	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	107	$138.48	$14,817	14,119
2021-04-21	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	530	$137.60	$72,928	14,226
2021-04-21	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	1,892	$136.84	$258,901	14,756
2021-04-21	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	203	$135.41	$27,488	16,648
2021-04-20	Poulton Jeffrey V.	Chief Financial Officer	Other disposed transaction F	Common Stock	50	$134.49	$6,724	3,135
2021-04-20	Poulton Jeffrey V.	Chief Financial Officer	Other disposed transaction F	Common Stock	1,333	$131.75	$175,623	3,185
2021-04-20	Vaishnaw Akshay	President, R&D	Other disposed transaction F	Common Stock	85	$134.56	$11,438	16,851
2021-04-20	Vaishnaw Akshay	President, R&D	Other disposed transaction F	Common Stock	2,266	$131.75	$298,546	16,936
2021-04-19	Poulton Jeffrey V.	Chief Financial Officer	Equity grant / award A	Common Stock	4,518	$0.00	$0	4,518
2021-04-19	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	417	$140.02	$58,388	19,202
2021-04-19	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	622	$138.64	$86,234	19,619
2021-04-19	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	989	$137.60	$136,086	20,241
2021-04-19	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	1,678	$136.76	$229,483	21,230
2021-04-19	Vaishnaw Akshay	President, R&D	Equity grant / award A	Common Stock	5,083	$0.00	$0	22,908
2021-02-24	Vaishnaw Akshay	President, R&D	Equity grant / award A · derivative	Stock Option (right to buy)	28,800	$0.00	$0	28,800
2021-02-12	Vaishnaw Akshay	President, R&D	Other disposed transaction F	Common Stock	92	$152.53	$14,033	17,825
2021-02-12	Vaishnaw Akshay	President, R&D	Other disposed transaction F	Common Stock	1,618	$156.00	$252,408	17,917
2021-02-11	Vaishnaw Akshay	President, R&D	Equity grant / award A · derivative	Performance Stock Option 2017 (right to buy)	8,334	$0.00	$0	25,000
2021-02-11	Vaishnaw Akshay	President, R&D	Equity grant / award A	Common Stock	5,416	$0.00	$0	19,535
2021-01-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	6,000	$0.00	$0	19,000
2021-01-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	3,027	$0.00	$0	2,164
2021-01-13	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,027	$174.00	$178,698	2,234
2021-01-13	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	3,000	$170.00	$510,000	3,261
2021-01-13	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	5,000	$169.00	$845,000	6,261
2021-01-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	6,000	$85.00	$510,000	11,261
2021-01-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	3,027	$77.40	$234,290	5,261
2021-01-12	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	13,000	$0.00	$0	5,191
2021-01-12	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,941	$0.00	$0	2,370
2021-01-12	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	3,000	$165.00	$495,000	2,234
2021-01-12	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	11,941	$159.00	$1,898,619	5,234
2021-01-12	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	13,000	$77.40	$1,006,200	17,175
2021-01-12	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	1,941	$42.22	$81,949	4,175
2021-01-12	Greenstreet Yvonne	President & COO	Exercise / conversion M · derivative	Stock Option (right to buy)	3,125	$0.00	$0	0
2021-01-12	Greenstreet Yvonne	President & COO	Open-market sell S	Common Stock	3,125	$161.00	$503,125	4,820
2021-01-12	Greenstreet Yvonne	President & COO	Exercise / conversion M	Common Stock	3,125	$42.22	$131,938	7,945
2021-01-11	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	758	$154.00	$116,732	2,234
2020-12-18	PAUL STEVEN M	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2020-12-18	PAUL STEVEN M	Dir	Open-market sell S	Common Stock	15,000	$140.00	$2,100,000	1,000
2020-12-18	PAUL STEVEN M	Dir	Exercise / conversion M	Common Stock	15,000	$9.30	$139,500	16,000
2020-12-07	SHARP PHILLIP A	Dir	Equity grant / award G	Common Stock	235,633	$0.00	$0	266,899
2020-11-25	SHARP PHILLIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	30,000	$0.00	$0	0
2020-11-25	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	645	$127.44	$82,199	235,633
2020-11-25	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	2,117	$126.16	$267,081	236,278
2020-11-25	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	15,715	$125.05	$1,965,161	238,395
2020-11-25	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	11,523	$124.30	$1,432,309	254,110
2020-11-25	SHARP PHILLIP A	Dir	Exercise / conversion M	Common Stock	30,000	$9.30	$279,000	265,633
2020-11-19	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	34,765	$0.00	$0	0
2020-11-19	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	102	$126.62	$12,915	197,589
2020-11-19	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	10,187	$125.35	$1,276,940	197,691
2020-11-19	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	5,489	$124.49	$683,326	207,878
2020-11-19	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	18,987	$123.55	$2,345,844	213,367
2020-11-19	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	34,765	$9.14	$317,752	232,354
2020-09-29	Vaishnaw Akshay	President, R&D	Exercise / conversion M · derivative	Stock Option (right to buy)	971	$0.00	$0	3,338
2020-09-29	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	971	$140.00	$135,940	14,119
2020-09-29	Vaishnaw Akshay	President, R&D	Exercise / conversion M	Common Stock	971	$42.22	$40,996	15,090
2020-09-09	Greene Barry E	President	Exercise / conversion M · derivative	Stock Option (right to buy)	44,530	$0.00	$0	0
2020-09-09	Greene Barry E	President	Open-market sell S	Common Stock	3,346	$124.38	$416,175	70,343
2020-09-09	Greene Barry E	President	Open-market sell S	Common Stock	27,109	$123.39	$3,344,980	73,689
2020-09-09	Greene Barry E	President	Open-market sell S	Common Stock	14,075	$122.66	$1,726,440	100,798
2020-09-09	Greene Barry E	President	Exercise / conversion M	Common Stock	44,530	$9.14	$407,004	114,873
2020-08-20	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	34,765	$0.00	$0	34,765
2020-08-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	8,542	$136.86	$1,169,058	197,589
2020-08-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	21,448	$136.07	$2,918,429	206,131
2020-08-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	4,775	$135.09	$645,055	227,579
2020-08-20	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	34,765	$9.14	$317,752	232,354
2020-08-10	Greene Barry E	President	Exercise / conversion M · derivative	Stock Option (right to buy)	1,036	$0.00	$0	46,589
2020-08-10	Greene Barry E	President	Exercise / conversion M · derivative	Stock Option (right to buy)	1,124	$0.00	$0	38,876
2020-08-10	Greene Barry E	President	Exercise / conversion M · derivative	Stock Option (right to buy)	1,587	$0.00	$0	88,413
2020-08-10	Greene Barry E	President	Exercise / conversion M · derivative	Stock Option (right to buy)	1,184	$0.00	$0	23,816
2020-08-10	Greene Barry E	President	Exercise / conversion M	Common Stock	1,184	$42.22	$49,988	67,167
2020-08-10	Greene Barry E	President	Exercise / conversion M	Common Stock	1,124	$88.95	$99,980	65,983
2020-08-10	Greene Barry E	President	Exercise / conversion M	Common Stock	1,036	$96.45	$99,922	64,859
2020-08-10	Greene Barry E	President	Exercise / conversion M	Common Stock	1,587	$63.00	$99,981	63,823
2020-07-16	Greene Barry E	President	Equity grant / award G	Common Stock	155	$0.00	$0	3,176
2020-07-16	Greene Barry E	President	Equity grant / award G	Common Stock	3,176	$0.00	$0	0
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	6,250	$0.00	$0	7,500
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	23,809	$0.00	$0	18,191
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,941	$0.00	$0	4,311
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Performance Stock Option 2017 (right to buy)	3,750	$0.00	$0	5,416
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	9,530	$162.24	$1,546,147	2,992
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	15,618	$161.32	$2,519,496	12,522
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	14,236	$160.52	$2,285,163	28,140
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,061	$159.22	$168,932	42,376
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	2,323	$158.27	$367,661	43,437
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	4,482	$157.16	$704,391	45,760
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	6,250	$119.13	$744,562	50,242
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	3,750	$119.13	$446,738	43,992
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	23,809	$77.40	$1,842,817	40,242
2020-07-13	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	1,941	$42.22	$81,949	16,433
2020-07-10	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	46,639	$0.00	$0	28,064
2020-07-10	Greenstreet Yvonne	Chief Operating Officer	Open-market sell S	Common Stock	46,639	$161.00	$7,508,879	4,820
2020-07-10	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M	Common Stock	46,639	$77.10	$3,595,867	51,459
2020-07-09	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	297	$0.00	$0	74,703
2020-07-09	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	10,939	$0.00	$0	3,125
2020-07-09	Greenstreet Yvonne	Chief Operating Officer	Open-market sell S	Common Stock	11,236	$161.00	$1,808,996	4,820
2020-07-09	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M	Common Stock	297	$77.10	$22,899	16,056
2020-07-09	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M	Common Stock	10,939	$42.22	$461,845	15,759
2020-07-07	Greene Barry E	President	Exercise / conversion M · derivative	Stock Option (right to buy)	22,265	$0.00	$0	44,530
2020-07-07	Greene Barry E	President	Open-market sell S	Common Stock	22,265	$159.99	$3,562,177	62,236
2020-07-07	Greene Barry E	President	Exercise / conversion M	Common Stock	22,265	$9.14	$203,502	84,501
2020-07-01	HAMBURG MARGARET A	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	4,581	$0.00	$0	4,581
2020-06-22	Vaishnaw Akshay	President, R&D	Exercise / conversion M · derivative	Stock Option (right to buy)	970	$0.00	$0	4,309
2020-06-22	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	195	$152.97	$29,829	14,119
2020-06-22	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	334	$152.22	$50,841	14,314
2020-06-22	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	180	$150.34	$27,061	14,648
2020-06-22	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	83	$149.09	$12,374	14,828
2020-06-22	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	178	$148.48	$26,429	14,911
2020-06-22	Vaishnaw Akshay	President, R&D	Exercise / conversion M	Common Stock	970	$42.22	$40,953	15,089
2020-05-20	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	34,765	$0.00	$0	69,530
2020-05-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	5,013	$144.33	$723,526	197,589
2020-05-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	16,315	$143.46	$2,340,550	202,602
2020-05-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	13,437	$142.51	$1,914,907	218,917
2020-05-20	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	34,765	$9.14	$317,752	232,354
2020-05-06	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	50,000	$0.00	$0	75,000
2020-05-06	Greenstreet Yvonne	Chief Operating Officer	Open-market sell S	Common Stock	50,000	$150.00	$7,500,000	4,820
2020-05-06	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M	Common Stock	50,000	$77.10	$3,855,000	54,820
2020-05-06	Greene Barry E	President	Exercise / conversion M · derivative	Stock Option (right to buy)	22,265	$0.00	$0	66,795
2020-05-06	Greene Barry E	President	Open-market sell S	Common Stock	22,265	$149.99	$3,339,527	62,236
2020-05-06	Greene Barry E	President	Exercise / conversion M	Common Stock	22,265	$9.14	$203,502	84,501
2020-05-05	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,561	$0.00	$0	14,064
2020-05-05	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M · derivative	Performance Stock Option 2016 (right to buy)	6,250	$0.00	$0	650
2020-05-05	Greenstreet Yvonne	Chief Operating Officer	Open-market sell S	Common Stock	7,811	$140.00	$1,093,540	4,820
2020-05-05	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M	Common Stock	1,561	$42.22	$65,905	12,631
2020-05-05	Greenstreet Yvonne	Chief Operating Officer	Exercise / conversion M	Common Stock	6,250	$42.22	$263,875	11,070
2020-04-20	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	10,000	$0.00	$0	42,000
2020-04-20	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	10,000	$139.00	$1,390,000	14,492
2020-04-20	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	10,000	$77.40	$774,000	24,492
2020-04-07	Greene Barry E	President	Other disposed transaction F	Common Stock	64	$106.65	$6,826	62,236
2020-04-07	Greene Barry E	President	Other disposed transaction F	Common Stock	1,599	$104.75	$167,495	62,300
2020-04-07	Greene Barry E	President	Equity grant / award A	Common Stock	5,417	$0.00	$0	63,899
2020-03-02	BRANDICOURT OLIVIER	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	8,612	$0.00	$0	8,612
2020-02-26	Poulton Jeffrey V.	Chief Financial Officer	Equity grant / award A · derivative	Stock Option (right to buy)	24,554	$118.05	$2,898,600	24,554
2020-02-26	KEATING LAURIE	EVP, Chief Legal Officer	Equity grant / award A · derivative	Stock Option (right to buy)	24,554	$0.00	$0	24,554
2020-02-20	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	34,765	$0.00	$0	104,295
2020-02-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	502	$133.42	$66,977	189,993
2020-02-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	18,065	$132.81	$2,399,213	190,495
2020-02-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	6,887	$131.61	$906,398	208,560
2020-02-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	5,053	$131.07	$662,297	215,447
2020-02-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	1,586	$129.33	$205,117	220,500
2020-02-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	2,672	$128.62	$343,673	222,086
2020-02-20	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	34,765	$9.14	$317,752	224,758
2020-02-12	SHARP PHILLIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2020-02-12	SHARP PHILLIP A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	15,000	$0.00	$0	0
2020-02-12	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	30,000	$130.00	$3,900,000	235,633
2020-02-12	SHARP PHILLIP A	Dir	Exercise / conversion M	Common Stock	15,000	$9.14	$137,100	265,633
2020-02-10	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	10,000	$0.00	$0	52,000
2020-02-10	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	10,000	$129.00	$1,290,000	12,258
2020-02-10	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	10,000	$77.40	$774,000	22,258
2020-02-07	Vaishnaw Akshay	President, R&D	Exercise / conversion M · derivative	Stock Option (right to buy)	18,750	$0.00	$0	6,250
2020-02-07	Vaishnaw Akshay	President, R&D	Exercise / conversion M · derivative	Performance Stock Option 2016 (right to buy)	4,000	$0.00	$0	21,000
2020-02-07	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	23,708	$125.00	$2,963,500	11,215
2020-02-07	Vaishnaw Akshay	President, R&D	Exercise / conversion M	Common Stock	4,000	$42.22	$168,880	34,923
2020-02-07	Vaishnaw Akshay	President, R&D	Exercise / conversion M	Common Stock	18,750	$42.22	$791,625	30,923
2020-01-29	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	6,337	$0.00	$0	62,000
2020-01-29	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	6,337	$119.00	$754,103	8,595
2020-01-29	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	6,337	$77.40	$490,484	14,932
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	3,663	$0.00	$0	68,337
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	9,374	$0.00	$0	6,252
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Performance Stock Option 2016 (right to buy)	25,000	$0.00	$0	0
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	190	$120.21	$22,840	8,595
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	6,667	$119.53	$796,907	8,785
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	13,084	$118.61	$1,551,893	15,452
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	4,100	$117.67	$482,447	28,536
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	13,631	$116.43	$1,587,057	32,636
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Open-market sell S	Common Stock	3,365	$115.55	$388,826	46,267
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	25,000	$42.22	$1,055,500	49,632
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	9,374	$42.22	$395,770	24,632
2020-01-27	KEATING LAURIE	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	3,663	$77.40	$283,516	12,258
2020-01-03	Poulton Jeffrey V.	Chief Financial Officer	Other acquired transaction J	Common Stock	19	$0.00	$0	19
2019-12-23	Vaishnaw Akshay	President, R&D	Equity grant / award A · derivative	Performance Stock Option 2017 (right to buy)	8,333	$0.00	$0	16,666
2019-12-12	Greenstreet Yvonne	Chief Operating Officer	Other disposed transaction F	Common Stock	3,208	$120.61	$386,917	6,208
2019-12-12	Greenstreet Yvonne	Chief Operating Officer	Equity grant / award A	Common Stock	7,500	$0.00	$0	9,416
2019-11-22	Greene Barry E	President	Equity grant / award A · derivative	Performance Stock Option 2017 (right to buy)	9,999	$0.00	$0	9,999
2019-11-20	Fanucci Marsha	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2019-11-20	Fanucci Marsha	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	15,000	$0.00	$0	0
2019-11-20	Fanucci Marsha	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	30,000	$0.00	$0	0
2019-11-20	Fanucci Marsha	Dir	Open-market sell S	Common Stock	75,000	$100.00	$7,500,000	0
2019-11-20	Fanucci Marsha	Dir	Exercise / conversion M	Common Stock	15,000	$30.09	$451,350	75,000
2019-11-20	Fanucci Marsha	Dir	Exercise / conversion M	Common Stock	30,000	$9.14	$274,200	30,000
2019-11-18	SHARP PHILLIP A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	15,000	$0.00	$0	0
2019-11-18	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	810	$92.66	$75,055	235,633
2019-11-18	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	8,631	$91.97	$793,793	236,443
2019-11-18	SHARP PHILLIP A	Dir	Open-market sell S	Common Stock	5,559	$91.17	$506,814	245,074
2019-11-18	SHARP PHILLIP A	Dir	Exercise / conversion M	Common Stock	15,000	$16.43	$246,450	250,633
2019-10-23	Greene Barry E	President	Other disposed transaction J	Common Stock	5,544	$0.00	$0	3,486
2019-10-22	Greene Barry E	President	Exercise / conversion M · derivative	Stock Option (right to buy)	58,913	$0.00	$0	0
2019-10-22	Greene Barry E	President	Open-market sell S	Common Stock	58,913	$89.99	$5,301,581	52,938
2019-10-22	Greene Barry E	President	Exercise / conversion M	Common Stock	58,913	$16.43	$967,941	111,851
2019-10-14	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	49,456	$0.00	$0	0
2019-10-14	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	1,870	$80.31	$150,180	189,993
2019-10-14	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	26,754	$79.80	$2,134,969	191,863
2019-10-14	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	20,832	$78.92	$1,644,061	218,617
2019-10-14	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	49,456	$16.43	$812,562	239,449
2019-10-10	Poulton Jeffrey V.	Chief Financial Officer	Other acquired transaction J	Common Stock	38	$0.00	$0	38
2019-08-06	Greenstreet Yvonne	Chief Operating Officer	Equity grant / award A · derivative	Performance Stock Option 2016 (right to buy)	6,250	$0.00	$0	25,000
2019-07-11	Greenstreet Yvonne	Chief Operating Officer	Other acquired transaction J	Common Stock	50	$0.00	$0	407
2019-07-01	BONNEY MICHAEL W	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	9,000	$0.00	$0	9,000
2019-06-05	MARAGANORE JOHN	Chief Executive Officer	Equity grant / award A · derivative	Performance Stock Option 2016 (right to buy)	6,250	$0.00	$0	18,750
2019-05-15	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	49,457	$0.00	$0	49,456
2019-05-15	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	49,457	$70.00	$3,461,990	189,993
2019-05-15	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	49,457	$16.43	$812,579	239,450
2019-04-15	SHARP PHILIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2019-04-15	SHARP PHILIP A	Dir	Open-market sell S	Common Stock	600	$91.40	$54,840	235,633
2019-04-15	SHARP PHILIP A	Dir	Open-market sell S	Common Stock	400	$89.97	$35,988	236,233
2019-04-15	SHARP PHILIP A	Dir	Open-market sell S	Common Stock	2,200	$89.03	$195,866	236,633
2019-04-15	SHARP PHILIP A	Dir	Open-market sell S	Common Stock	11,800	$87.86	$1,036,748	238,833
2019-04-15	SHARP PHILIP A	Dir	Exercise / conversion M	Common Stock	15,000	$22.09	$331,350	250,633
2019-04-09	MARAGANORE JOHN	Chief Executive Officer	Other acquired transaction J	Common Stock	61	$0.00	$0	3,099
2019-02-28	Greenstreet Yvonne	EVP, Chief Operating Officer	Equity grant / award A · derivative	Stock Option (right to buy)	32,500	$0.00	$0	32,500
2019-01-10	HAMBURG MARGARET A	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	18,000	$0.00	$0	18,000
2018-11-21	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	98,636	$0.00	$0	0
2018-11-21	MARAGANORE JOHN	Chief Executive Officer	Other disposed transaction F	Common Stock	59,940	$72.68	$4,356,439	189,993
2018-11-21	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	98,636	$21.35	$2,105,879	249,933
2018-10-18	MARAGANORE JOHN	Chief Executive Officer	Other acquired transaction J	Common Stock	17	$0.00	$0	3,038
2018-09-27	KEATING LAURIE	SVP, GC & Secretary	Equity grant / award A · derivative	Performance Stock Option 2016 (right to buy)	6,250	$0.00	$0	12,500
2018-09-27	KEATING LAURIE	SVP, GC & Secretary	Equity grant / award A · derivative	Performance Stock Option 2015 (right to buy)	3,500	$0.00	$0	10,500
2018-08-30	Greenstreet Yvonne	EVP, Chief Operating Officer	Open-market sell S	Common Stock	2,500	$120.00	$300,000	1,916
2018-08-21	MARAGANORE JOHN	Chief Executive Officer	Equity grant / award A · derivative	Performance Stock Option 2015 (right to buy)	16,250	$0.00	$0	32,500
2018-08-13	Greenstreet Yvonne	EVP, Chief Operating Officer	Equity grant / award A · derivative	Performance Stock Option 2016 (right to buy)	25,000	$0.00	$0	25,000
2018-08-13	Greenstreet Yvonne	EVP, Chief Operating Officer	Other disposed transaction F	Common Stock	3,084	$90.95	$280,490	4,416
2018-08-13	Greenstreet Yvonne	EVP, Chief Operating Officer	Equity grant / award A	Common Stock	7,500	$0.00	$0	7,500
2018-08-10	Greene Barry E	President	Equity grant / award A · derivative	Performance Based Stock Option 2014 (right to buy)	15,875	$0.00	$0	47,625
2018-08-10	Greene Barry E	President	Equity grant / award A · derivative	Performance Based Stock Option 2013 (right to buy)	15,000	$0.00	$0	45,000
2018-07-31	Greene Barry E	President	Equity grant / award G	Common Stock	9,030	$0.00	$0	9,030
2018-07-25	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	50,000	$0.00	$0	98,636
2018-07-25	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	1,400	$106.25	$148,750	151,297
2018-07-25	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	34,995	$105.83	$3,703,521	152,697
2018-07-25	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	7,758	$104.83	$813,271	187,692
2018-07-25	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	3,847	$103.69	$398,895	195,450
2018-07-25	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	2,000	$102.51	$205,020	199,297
2018-07-25	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	50,000	$21.35	$1,067,500	201,297
2018-07-10	MARAGANORE JOHN	Chief Executive Officer	Other acquired transaction J	Common Stock	31	$0.00	$0	3,021
2018-07-10	Greenstreet Yvonne	EVP, Chief Operating Officer	Other acquired transaction J	Common Stock	38	$0.00	$0	308
2018-07-10	Greene Barry E	President	Other acquired transaction J	Common Stock	29	$0.00	$0	2,884
2018-06-20	KEATING LAURIE	SVP, GC & Secretary	Exercise / conversion M · derivative	Stock Option (right to buy)	1,563	$0.00	$0	15,626
2018-06-20	KEATING LAURIE	SVP, GC & Secretary	Open-market sell S	Common Stock	1,563	$105.04	$164,178	14,500
2018-06-20	KEATING LAURIE	SVP, GC & Secretary	Exercise / conversion M	Common Stock	1,563	$42.22	$65,990	16,063
2018-06-20	SHARP PHILIP A	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	9,000	$0.00	$0	9,000
2018-06-01	Reitan Colleen F	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	18,000	$0.00	$0	18,000
2018-05-31	CLARKE JOHN K	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2018-05-31	CLARKE JOHN K	Dir	Open-market sell S	Common Stock	100	$101.97	$10,197	8,891
2018-05-31	CLARKE JOHN K	Dir	Open-market sell S	Common Stock	2,100	$101.37	$212,877	8,991
2018-05-31	CLARKE JOHN K	Dir	Open-market sell S	Common Stock	10,042	$100.33	$1,007,514	11,091
2018-05-31	CLARKE JOHN K	Dir	Open-market sell S	Common Stock	2,758	$99.38	$274,090	21,133
2018-05-31	CLARKE JOHN K	Dir	Exercise / conversion M	Common Stock	15,000	$27.28	$409,200	23,891
2018-04-16	KEATING LAURIE	SVP, GC & Secretary	Other acquired transaction J	Common Stock	31	$0.00	$0	288
2018-04-16	MARAGANORE JOHN	Chief Executive Officer	Other acquired transaction J	Common Stock	30	$0.00	$0	2,990
2018-04-16	Greenstreet Yvonne	EVP, Chief Operating Officer	Other acquired transaction J	Common Stock	37	$0.00	$0	270
2018-04-16	Greene Barry E	President	Other acquired transaction J	Common Stock	28	$0.00	$0	2,855
2018-03-26	Greenstreet Yvonne	EVP, Chief Operating Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	7,221	$0.00	$0	17,779
2018-03-26	Greenstreet Yvonne	EVP, Chief Operating Officer	Other acquired transaction J	Common Stock	233	$0.00	$0	233
2018-03-26	Greenstreet Yvonne	EVP, Chief Operating Officer	Open-market sell S	Common Stock	100	$141.47	$14,147	0
2018-03-26	Greenstreet Yvonne	EVP, Chief Operating Officer	Open-market sell S	Common Stock	419	$137.78	$57,730	100
2018-03-26	Greenstreet Yvonne	EVP, Chief Operating Officer	Open-market sell S	Common Stock	2,394	$137.09	$328,193	519
2018-03-26	Greenstreet Yvonne	EVP, Chief Operating Officer	Open-market sell S	Common Stock	4,308	$136.00	$585,888	2,913
2018-03-26	Greenstreet Yvonne	EVP, Chief Operating Officer	Exercise / conversion M	Common Stock	7,221	$42.22	$304,871	7,221
2018-03-20	KEATING LAURIE	SVP, GC & Secretary	Exercise / conversion M · derivative	Stock Option (right to buy)	1,562	$0.00	$0	17,189
2018-03-20	KEATING LAURIE	SVP, GC & Secretary	Open-market sell S	Common Stock	300	$152.79	$45,837	14,500
2018-03-20	KEATING LAURIE	SVP, GC & Secretary	Open-market sell S	Common Stock	200	$151.48	$30,296	14,800
2018-03-20	KEATING LAURIE	SVP, GC & Secretary	Open-market sell S	Common Stock	500	$149.97	$74,985	15,000
2018-03-20	KEATING LAURIE	SVP, GC & Secretary	Open-market sell S	Common Stock	462	$147.79	$68,279	15,500
2018-03-20	KEATING LAURIE	SVP, GC & Secretary	Open-market sell S	Common Stock	100	$146.36	$14,636	15,962
2018-03-20	KEATING LAURIE	SVP, GC & Secretary	Exercise / conversion M	Common Stock	1,562	$42.22	$65,948	16,062
2018-03-14	Vaishnaw Akshay	President, R&D	Exercise / conversion M · derivative	Stock Option (right to buy)	44,641	$0.00	$0	0
2018-03-14	Vaishnaw Akshay	President, R&D	Exercise / conversion M · derivative	Stock Option (right to buy)	38,913	$0.00	$0	0
2018-03-14	Vaishnaw Akshay	President, R&D	Exercise / conversion M · derivative	Stock Option (right to buy)	5,000	$0.00	$0	0
2018-03-14	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	6,380	$145.27	$926,823	11,215
2018-03-14	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	20,172	$144.53	$2,915,459	17,595
2018-03-14	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	19,213	$143.46	$2,756,297	37,767
2018-03-14	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	21,336	$142.57	$3,041,874	56,980
2018-03-14	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	15,000	$141.69	$2,125,350	78,316
2018-03-14	Vaishnaw Akshay	President, R&D	Open-market sell S	Common Stock	6,453	$140.45	$906,324	93,316
2018-03-14	Vaishnaw Akshay	President, R&D	Exercise / conversion M	Common Stock	5,000	$7.10	$35,500	99,769
2018-03-14	Vaishnaw Akshay	President, R&D	Exercise / conversion M	Common Stock	38,913	$16.43	$639,341	94,769
2018-03-14	Vaishnaw Akshay	President, R&D	Exercise / conversion M	Common Stock	44,641	$18.66	$833,001	55,856
2018-03-13	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	2,117	$0.00	$0	0
2018-03-13	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2018-03-13	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	17,117	$150.00	$2,567,550	0
2018-03-13	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	15,000	$59.25	$888,750	17,117
2018-03-13	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	2,117	$63.86	$135,192	2,117
2018-03-13	KEATING LAURIE	SVP, GC & Secretary	Exercise / conversion M · derivative	Stock Option (right to buy)	10,000	$0.00	$0	72,000
2018-03-13	KEATING LAURIE	SVP, GC & Secretary	Open-market sell S	Common Stock	10,000	$150.00	$1,500,000	14,500
2018-03-13	KEATING LAURIE	SVP, GC & Secretary	Exercise / conversion M	Common Stock	10,000	$77.40	$774,000	24,500
2018-03-12	KEATING LAURIE	SVP, GC & Secretary	Exercise / conversion M · derivative	Stock Option (right to buy)	10,000	$0.00	$0	82,000
2018-03-12	KEATING LAURIE	SVP, GC & Secretary	Open-market sell S	Common Stock	10,000	$140.00	$1,400,000	14,500
2018-03-12	KEATING LAURIE	SVP, GC & Secretary	Exercise / conversion M	Common Stock	10,000	$77.40	$774,000	24,500
2018-03-09	SHARP PHILIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2018-03-09	SHARP PHILIP A	Dir	Open-market sell S	Common Stock	15,000	$129.00	$1,935,000	140,795
2018-03-09	SHARP PHILIP A	Dir	Exercise / conversion M	Common Stock	15,000	$27.28	$409,200	155,795
2018-03-01	Vaishnaw Akshay	EVP, R&D	Equity grant / award A · derivative	Stock Option (right to buy)	25,000	$0.00	$0	25,000
2018-01-17	Greene Barry E	President	Other acquired transaction J	Common Stock	17	$0.00	$0	2,827
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M · derivative	Stock Option (right to buy)	10,000	$0.00	$0	0
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M · derivative	Stock Option (right to buy)	6,187	$0.00	$0	2,063
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M · derivative	Stock Option (right to buy)	3,600	$0.00	$0	3,600
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M · derivative	Stock Option (right to buy)	3,439	$0.00	$0	0
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,388	$0.00	$0	4,162
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M · derivative	Performance Stock Option 2014 (right to buy)	2,750	$0.00	$0	0
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M · derivative	Performance Stock Option 2013 (right to buy)	1,667	$0.00	$0	0
2018-01-04	Mason Michael	VP, Finance and Treasurer	Open-market sell S	Common Stock	600	$135.00	$81,000	0
2018-01-04	Mason Michael	VP, Finance and Treasurer	Open-market sell S	Common Stock	400	$133.83	$53,532	600
2018-01-04	Mason Michael	VP, Finance and Treasurer	Open-market sell S	Common Stock	1,591	$132.98	$211,571	1,000
2018-01-04	Mason Michael	VP, Finance and Treasurer	Open-market sell S	Common Stock	12,405	$132.18	$1,639,693	2,591
2018-01-04	Mason Michael	VP, Finance and Treasurer	Open-market sell S	Common Stock	16,500	$131.20	$2,164,800	14,996
2018-01-04	Mason Michael	VP, Finance and Treasurer	Open-market sell S	Common Stock	5,249	$130.42	$684,575	31,496
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M	Common Stock	3,439	$63.00	$216,657	36,745
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M	Common Stock	6,187	$96.45	$596,736	33,306
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M	Common Stock	10,000	$97.72	$977,200	27,119
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M	Common Stock	2,750	$96.45	$265,238	17,119
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M	Common Stock	3,600	$88.95	$320,220	11,619
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M	Common Stock	1,667	$63.00	$105,021	8,019
2018-01-04	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M	Common Stock	1,388	$42.22	$58,601	6,352
2017-12-30	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M · derivative	Restricted Stock Unit	8,502	$0.00	$0	0
2017-12-30	Mason Michael	VP, Finance and Treasurer	Other disposed transaction F	Common Stock	3,538	$127.05	$449,503	4,964
2017-12-30	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M	Common Stock	8,502	$0.00	$0	8,502
2017-12-29	KEATING LAURIE	SVP, GC & Secretary	Exercise / conversion M · derivative	Stock Option (right to buy)	3,000	$0.00	$0	92,000
2017-12-29	KEATING LAURIE	SVP, GC & Secretary	Exercise / conversion M	Common Stock	3,000	$77.40	$232,200	14,500
2017-12-20	MARAGANORE JOHN	Chief Executive Officer	Equity grant / award A · derivative	Performance Based Stock Option 2016 (right to buy)	6,250	$0.00	$0	6,250
2017-12-20	Mason Michael	VP, Finance and Treasurer	Equity grant / award A · derivative	Performance Stock Option 2016 (right to buy)	1,388	$0.00	$0	1,388
2017-12-19	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,587	$0.00	$0	148,413
2017-12-19	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	1,587	$63.00	$99,981	151,297
2017-12-01	KEATING LAURIE	SVP, GC and Secretary	Exercise / conversion M · derivative	Stock Option (Right to Buy)	30,000	$0.00	$0	95,000
2017-12-01	KEATING LAURIE	SVP, GC and Secretary	Open-market sell S	Common Stock	6,199	$137.29	$851,061	11,500
2017-12-01	KEATING LAURIE	SVP, GC and Secretary	Open-market sell S	Common Stock	9,700	$136.50	$1,324,050	17,699
2017-12-01	KEATING LAURIE	SVP, GC and Secretary	Open-market sell S	Common Stock	7,500	$135.56	$1,016,700	27,399
2017-12-01	KEATING LAURIE	SVP, GC and Secretary	Open-market sell S	Common Stock	3,801	$134.59	$511,577	34,899
2017-12-01	KEATING LAURIE	SVP, GC and Secretary	Open-market sell S	Common Stock	2,800	$133.37	$373,436	38,700
2017-12-01	KEATING LAURIE	SVP, GC and Secretary	Exercise / conversion M	Common Stock	30,000	$77.40	$2,322,000	41,500
2017-11-22	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	73,415	$0.00	$0	0
2017-11-22	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	2,683	$132.73	$356,115	149,710
2017-11-22	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	20,433	$131.82	$2,693,478	152,393
2017-11-22	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	25,036	$130.88	$3,276,712	172,826
2017-11-22	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	25,263	$129.97	$3,283,432	197,862
2017-11-22	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	73,415	$31.39	$2,304,497	223,125
2017-11-15	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	74,000	$0.00	$0	73,415
2017-11-15	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	600	$130.22	$78,131	149,710
2017-11-15	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	4,850	$129.57	$628,414	150,310
2017-11-15	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	10,571	$128.48	$1,358,204	155,160
2017-11-15	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	7,120	$127.54	$908,085	165,731
2017-11-15	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	28,399	$126.60	$3,595,399	172,851
2017-11-15	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	22,460	$125.54	$2,819,718	201,250
2017-11-15	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	74,000	$31.39	$2,322,860	223,710
2017-11-06	Vaishnaw Akshay	EVP, R&D	Equity grant / award A · derivative	Performance Stock Option 2015 (right to buy)	7,500	$0.00	$0	7,500
2017-11-02	Ausiello Dennis A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	20,000	$0.00	$0	0
2017-11-02	Ausiello Dennis A	Dir	Open-market sell S	Common Stock	20,000	$130.00	$2,600,000	0
2017-11-02	Ausiello Dennis A	Dir	Exercise / conversion M	Common Stock	20,000	$30.09	$601,800	20,000
2017-10-30	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	33,666	$0.00	$0	0
2017-10-30	Vaishnaw Akshay	EVP, R&D	Open-market sell S	Common Stock	3,693	$122.79	$453,463	11,535
2017-10-30	Vaishnaw Akshay	EVP, R&D	Open-market sell S	Common Stock	17,755	$121.69	$2,160,606	15,228
2017-10-30	Vaishnaw Akshay	EVP, R&D	Open-market sell S	Common Stock	11,418	$120.78	$1,379,066	32,983
2017-10-30	Vaishnaw Akshay	EVP, R&D	Open-market sell S	Common Stock	800	$119.79	$95,832	44,401
2017-10-30	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M	Common Stock	33,666	$21.35	$718,769	45,201
2017-10-02	Greene Barry E	President	Exercise / conversion M · derivative	Stock Option (Right to Buy)	85,316	$0.00	$0	0
2017-10-02	Greene Barry E	President	Open-market sell S	Common Stock	85,316	$125.00	$10,664,500	100,428
2017-10-02	Greene Barry E	President	Exercise / conversion M	Common Stock	85,316	$21.35	$1,821,497	185,744
2017-09-20	Vaishnaw Akshay	EVP, R&D	Equity grant / award A · derivative	Performance Stock Option 2013 (right to buy)	10,834	$0.00	$0	10,834
2017-07-07	Vaishnaw Akshay	EVP, R&D	Equity grant / award A · derivative	Performance Stock Option 2014 (right to buy)	11,709	$0.00	$0	23,418
2017-06-13	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	328	$0.00	$0	33,666
2017-06-13	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,340	$0.00	$0	44,641
2017-06-13	Vaishnaw Akshay	EVP, R&D	Other disposed transaction F	Common Stock	430	$74.31	$31,953	11,535
2017-06-13	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M	Common Stock	1,340	$18.66	$25,004	11,965
2017-06-13	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M	Common Stock	328	$21.35	$7,003	10,625
2017-06-02	STARR KEVIN P	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	11,250	$0.00	$0	11,250
2017-05-31	Sanofi	10%	Open-market buy P	Common Stock	297,501	$71.87	$21,381,397	10,554,134
2017-05-30	KEATING LAURIE	SVP, GC and Secretary	Open-market buy P	Common Stock	11,500	$65.35	$751,502	11,500
2017-05-23	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	11,000	$0.00	$0	33,994
2017-05-23	Vaishnaw Akshay	EVP, R&D	Open-market sell S	Common Stock	11,000	$75.00	$825,000	10,297
2017-05-23	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M	Common Stock	11,000	$21.35	$234,850	21,297
2017-05-16	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,625	$0.00	$0	0
2017-05-16	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,750	$0.00	$0	0
2017-05-16	Mason Michael	VP, Finance and Treasurer	Open-market sell S	Common Stock	9,375	$70.00	$656,250	0
2017-05-16	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M	Common Stock	3,750	$7.10	$26,625	9,375
2017-05-16	Mason Michael	VP, Finance and Treasurer	Exercise / conversion M	Common Stock	5,625	$18.66	$104,962	5,625
2017-05-15	Vaishnaw Akshay	SVP, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	32,750	$0.00	$0	0
2017-05-15	Vaishnaw Akshay	SVP, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	11,000	$0.00	$0	44,994
2017-05-15	Vaishnaw Akshay	SVP, R&D	Open-market sell S	Common Stock	11,000	$65.00	$715,000	10,297
2017-05-15	Vaishnaw Akshay	SVP, R&D	Exercise / conversion M	Common Stock	11,000	$21.35	$234,850	21,297
2017-05-15	Vaishnaw Akshay	SVP, R&D	Open-market sell S	Common Stock	32,750	$65.00	$2,128,750	10,297
2017-05-15	Vaishnaw Akshay	SVP, R&D	Exercise / conversion M	Common Stock	32,750	$31.39	$1,028,022	43,047
2017-02-01	SHARP PHILIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	25,000	$0.00	$0	0
2017-02-01	SHARP PHILIP A	Dir	Open-market sell S	Common Stock	4,829	$40.16	$193,933	140,795
2017-02-01	SHARP PHILIP A	Dir	Open-market sell S	Common Stock	20,171	$39.72	$801,192	145,624
2017-02-01	SHARP PHILIP A	Dir	Exercise / conversion M	Common Stock	25,000	$31.29	$782,250	165,795
2017-01-25	SHARP PHILIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2017-01-25	SHARP PHILIP A	Dir	Open-market sell S	Common Stock	15,000	$37.95	$569,250	140,795
2017-01-25	SHARP PHILIP A	Dir	Exercise / conversion M	Common Stock	15,000	$31.39	$470,850	155,795
2017-01-18	SHARP PHILIP A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2017-01-18	SHARP PHILIP A	Dir	Open-market sell S	Common Stock	6,200	$38.20	$236,840	140,795
2017-01-18	SHARP PHILIP A	Dir	Open-market sell S	Common Stock	8,800	$37.57	$330,616	146,995
2017-01-18	SHARP PHILIP A	Dir	Exercise / conversion M	Common Stock	15,000	$15.91	$238,650	155,795
2017-01-05	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,340	$0.00	$0	144,641
2017-01-05	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	1,340	$18.66	$25,004	149,710
2016-12-30	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,356	$0.00	$0	55,994
2016-12-30	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,019	$0.00	$0	45,981
2016-12-30	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,172	$0.00	$0	38,913
2016-12-30	Vaishnaw Akshay	EVP, R&D	Other disposed transaction F	Common Stock	5,000	$37.44	$187,200	10,297
2016-12-30	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M	Common Stock	4,356	$21.35	$93,001	15,297
2016-12-30	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M	Common Stock	4,019	$18.66	$74,995	10,941
2016-12-30	Vaishnaw Akshay	EVP, R&D	Exercise / conversion M	Common Stock	1,172	$16.43	$19,256	6,922
2016-12-20	Mason Michael	VP, Finance and Treasurer	Equity grant / award A · derivative	Stock Option (right to buy)	5,550	$0.00	$0	5,550
2016-12-12	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	30,151	$0.00	$0	0
2016-12-12	MARAGANORE JOHN	Chief Executive Officer	Other disposed transaction F	Common Stock	22,710	$42.61	$967,673	148,370
2016-12-12	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	30,151	$22.75	$685,935	171,080
2016-12-01	Greene Barry E	President	Exercise / conversion M · derivative	Stock Option (Right to Buy)	55,605	$0.00	$0	0
2016-12-01	Greene Barry E	President	Open-market sell S	Common Stock	500	$44.07	$22,036	88,584
2016-12-01	Greene Barry E	President	Open-market sell S	Common Stock	16,976	$43.28	$734,747	89,084
2016-12-01	Greene Barry E	President	Open-market sell S	Common Stock	14,349	$42.61	$611,345	106,060
2016-12-01	Greene Barry E	President	Exercise / conversion M	Common Stock	55,605	$22.75	$1,265,014	120,409
2016-11-30	Vaishnaw Akshay	EVP, R&D, CMO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	29,165	$0.00	$0	0
2016-11-30	Vaishnaw Akshay	EVP, R&D, CMO	Open-market sell S	Common Stock	1,500	$46.14	$69,208	5,750
2016-11-30	Vaishnaw Akshay	EVP, R&D, CMO	Open-market sell S	Common Stock	13,297	$45.55	$605,662	7,250
2016-11-30	Vaishnaw Akshay	EVP, R&D, CMO	Open-market sell S	Common Stock	14,368	$44.34	$637,127	20,547
2016-11-30	Vaishnaw Akshay	EVP, R&D, CMO	Exercise / conversion M	Common Stock	29,165	$22.75	$663,504	34,915
2016-10-13	PYOTT DAVID E I	Dir	Open-market buy P	Common Stock	27,900	$37.00	$1,032,328	27,900
2016-10-12	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,019	$0.00	$0	145,981
2016-10-12	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,521	$0.00	$0	135,915
2016-10-12	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	4,019	$18.66	$74,995	140,929
2016-10-12	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	3,521	$7.10	$24,999	136,910
2016-09-19	Greenstreet Yvonne	EVP, Chief Operating Officer	Equity grant / award A · derivative	Stock Option (right to buy)	125,000	$0.00	$0	125,000
2016-07-20	MARAGANORE JOHN	CEO	Exercise / conversion M · derivative	Stock Option (right to buy)	15,075	$0.00	$0	30,151
2016-07-20	MARAGANORE JOHN	CEO	Open-market sell S	Common Stock	2,418	$66.00	$159,586	133,389
2016-07-20	MARAGANORE JOHN	CEO	Open-market sell S	Common Stock	12,057	$65.56	$790,430	135,807
2016-07-20	MARAGANORE JOHN	CEO	Open-market sell S	Common Stock	600	$64.29	$38,575	147,864
2016-07-20	MARAGANORE JOHN	CEO	Exercise / conversion M	Common Stock	15,075	$22.75	$342,956	148,464
2016-07-19	MARAGANORE JOHN	CEO	Exercise / conversion M · derivative	Stock Option (right to buy)	15,076	$0.00	$0	45,226
2016-07-19	MARAGANORE JOHN	CEO	Open-market sell S	Common Stock	1,505	$64.56	$97,159	133,389
2016-07-19	MARAGANORE JOHN	CEO	Open-market sell S	Common Stock	13,571	$63.73	$864,839	134,894
2016-07-19	MARAGANORE JOHN	CEO	Exercise / conversion M	Common Stock	15,076	$22.75	$342,979	148,465
2016-06-03	STARR KEVIN P	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	11,250	$0.00	$0	11,250
2016-04-20	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	15,075	$0.00	$0	60,302
2016-04-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	2,405	$68.24	$164,128	133,389
2016-04-20	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	12,670	$67.38	$853,645	135,794
2016-04-20	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	15,075	$22.75	$342,956	148,464
2016-04-19	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	15,076	$0.00	$0	75,377
2016-04-19	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	300	$68.71	$20,612	133,389
2016-04-19	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	5,405	$68.00	$367,555	133,689
2016-04-19	MARAGANORE JOHN	Chief Executive Officer	Open-market sell S	Common Stock	9,371	$67.02	$628,032	139,094
2016-04-19	MARAGANORE JOHN	Chief Executive Officer	Exercise / conversion M	Common Stock	15,076	$22.75	$342,979	148,465

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count