Financial Metrics

AMGN AMGEN INC

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	2.5	—	USD/shares	10-Q	2017-04-27
Quarterly	2016-06-30	2.47	-1.2%	USD/shares	10-Q	2017-07-26
Quarterly	2016-09-30	2.68	+8.5%	USD/shares	10-Q	2017-10-26
Quarterly	2017-03-31	2.79	+4.1%	USD/shares	10-Q	2018-04-25
Quarterly	2017-06-30	2.91	+4.3%	USD/shares	10-Q	2018-07-27
Quarterly	2017-09-30	2.76	-5.2%	USD/shares	10-Q	2018-10-31
Quarterly	2018-03-31	3.25	+17.8%	USD/shares	10-Q	2019-05-01
Quarterly	2018-06-30	3.48	+7.1%	USD/shares	10-Q	2019-07-31
Quarterly	2018-09-30	2.86	-17.8%	USD/shares	10-Q	2019-10-30
Quarterly	2019-03-31	3.18	+11.2%	USD/shares	10-Q	2020-05-01
Quarterly	2019-06-30	3.57	+12.3%	USD/shares	10-Q	2020-07-29
Quarterly	2019-09-30	3.27	-8.4%	USD/shares	10-Q	2020-10-29
Quarterly	2020-03-31	3.07	-6.1%	USD/shares	10-Q	2021-04-28
Quarterly	2020-06-30	3.05	-0.7%	USD/shares	10-Q	2021-08-04
Quarterly	2020-09-30	3.43	+12.5%	USD/shares	10-Q	2021-11-03
Quarterly	2021-03-31	2.83	-17.5%	USD/shares	10-Q	2022-04-28
Quarterly	2021-06-30	0.81	-71.4%	USD/shares	10-Q	2022-08-05
Quarterly	2021-09-30	3.31	+308.6%	USD/shares	10-Q	2022-11-04
Quarterly	2022-03-31	2.68	-19.0%	USD/shares	10-Q	2023-04-28
Quarterly	2022-06-30	2.45	-8.6%	USD/shares	10-Q	2023-08-04
Quarterly	2022-09-30	3.98	+62.4%	USD/shares	10-Q	2023-10-31
Quarterly	2023-03-31	5.28	+32.7%	USD/shares	10-Q	2024-05-03
Quarterly	2023-06-30	2.57	-51.3%	USD/shares	10-Q	2024-08-07
Quarterly	2023-09-30	3.22	+25.3%	USD/shares	10-Q	2024-10-31
Quarterly	2024-03-31	-0.21	-106.5%	USD/shares	10-Q	2025-05-02
Quarterly	2024-06-30	1.38	+757.1%	USD/shares	10-Q	2025-08-06
Quarterly	2024-09-30	5.22	+278.3%	USD/shares	10-Q	2025-11-05
Quarterly	2025-03-31	3.2	-38.7%	USD/shares	10-Q	2025-05-02
Quarterly	2025-06-30	2.65	-17.2%	USD/shares	10-Q	2025-08-06
Quarterly	2025-09-30	5.93	+123.8%	USD/shares	10-Q	2025-11-05
Annual	2016-12-31	10.24	—	USD/shares	10-K	2019-02-13
Annual	2017-12-31	2.69	-73.7%	USD/shares	10-K	2020-02-12
Annual	2018-12-31	12.62	+369.1%	USD/shares	10-K	2021-02-09
Annual	2019-12-31	12.88	+2.1%	USD/shares	10-K	2022-02-16
Annual	2020-12-31	12.31	-4.4%	USD/shares	10-K	2023-02-09
Annual	2021-12-31	10.28	-16.5%	USD/shares	10-K	2024-02-14
Annual	2022-12-31	12.11	+17.8%	USD/shares	10-K	2025-02-14
Annual	2023-12-31	12.49	+3.1%	USD/shares	10-K	2026-02-13
Annual	2024-12-31	7.56	-39.5%	USD/shares	10-K	2026-02-13
Annual	2025-12-31	14.23	+88.2%	USD/shares	10-K	2026-02-13

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	34307000000.0	—	USD	10-Q	2016-05-02
Quarterly	2016-06-30	33222000000.0	-3.2%	USD	10-Q	2016-07-29
Quarterly	2016-09-30	35323000000.0	+6.3%	USD	10-Q	2016-10-28
Quarterly	2016-12-31	34596000000.0	-2.1%	USD	10-Q	2017-10-26
Quarterly	2017-03-31	34092000000.0	-1.5%	USD	10-Q	2017-04-27
Quarterly	2017-06-30	35062000000.0	+2.8%	USD	10-Q	2017-07-26
Quarterly	2017-09-30	35776000000.0	+2.0%	USD	10-Q	2017-10-26
Quarterly	2017-12-31	35342000000.0	-1.2%	USD	10-Q	2018-10-31
Quarterly	2018-03-31	35541000000.0	+0.6%	USD	10-Q	2018-04-25
Quarterly	2018-06-30	34497000000.0	-2.9%	USD	10-Q	2018-07-27
Quarterly	2018-09-30	34427000000.0	-0.2%	USD	10-Q	2018-10-31
Quarterly	2018-12-31	33929000000.0	-1.4%	USD	10-Q	2019-10-30
Quarterly	2019-03-31	33024000000.0	-2.7%	USD	10-Q	2019-05-01
Quarterly	2019-06-30	30614000000.0	-7.3%	USD	10-Q	2019-07-31
Quarterly	2019-09-30	29791000000.0	-2.7%	USD	10-Q	2019-10-30
Quarterly	2019-12-31	29903000000.0	+0.4%	USD	10-Q	2020-10-29
Quarterly	2020-03-31	31848000000.0	+6.5%	USD	10-Q	2020-05-01
Quarterly	2020-06-30	34224000000.0	+7.5%	USD	10-Q	2020-07-29
Quarterly	2020-09-30	34287000000.0	+0.2%	USD	10-Q	2020-10-29
Quarterly	2020-12-31	32986000000.0	-3.8%	USD	10-Q	2021-11-03
Quarterly	2021-03-31	32685000000.0	-0.9%	USD	10-Q	2021-04-28
Quarterly	2021-06-30	32782000000.0	+0.3%	USD	10-Q	2021-08-04
Quarterly	2021-09-30	37579000000.0	+14.6%	USD	10-Q	2021-11-03
Quarterly	2021-12-31	33309000000.0	-11.4%	USD	10-Q	2022-11-04
Quarterly	2022-03-31	36854000000.0	+10.6%	USD	10-Q	2022-04-28
Quarterly	2022-06-30	36522000000.0	-0.9%	USD	10-Q	2022-08-05
Quarterly	2022-09-30	38704000000.0	+6.0%	USD	10-Q	2022-11-04
Quarterly	2022-12-31	38945000000.0	+0.6%	USD	10-Q	2023-10-31
Quarterly	2023-03-31	61595000000.0	+58.2%	USD	10-Q	2023-04-28
Quarterly	2023-06-30	61544000000.0	-0.1%	USD	10-Q	2023-08-04
Quarterly	2023-09-30	60468000000.0	-1.7%	USD	10-Q	2023-10-31
Quarterly	2023-12-31	64613000000.0	+6.9%	USD	10-Q	2024-10-31
Quarterly	2024-03-31	64020000000.0	-0.9%	USD	10-Q	2024-05-03
Quarterly	2024-06-30	62645000000.0	-2.1%	USD	10-Q	2024-08-07
Quarterly	2024-09-30	60398000000.0	-3.6%	USD	10-Q	2024-10-31
Quarterly	2024-12-31	60099000000.0	-0.5%	USD	10-Q	2025-11-05
Quarterly	2025-03-31	57381000000.0	-4.5%	USD	10-Q	2025-05-02
Quarterly	2025-06-30	56204000000.0	-2.1%	USD	10-Q	2025-08-06
Quarterly	2025-09-30	54587000000.0	-2.9%	USD	10-Q	2025-11-05
Annual	2016-12-31	34596000000.0	—	USD	10-K	2018-02-13
Annual	2017-12-31	35342000000.0	+2.2%	USD	10-K	2019-02-13
Annual	2018-12-31	33929000000.0	-4.0%	USD	10-K	2020-02-12
Annual	2019-12-31	29903000000.0	-11.9%	USD	10-K	2021-02-09
Annual	2020-12-31	32986000000.0	+10.3%	USD	10-K	2022-02-16
Annual	2021-12-31	33309000000.0	+1.0%	USD	10-K	2023-02-09
Annual	2022-12-31	38945000000.0	+16.9%	USD	10-K	2024-02-14
Annual	2023-12-31	64613000000.0	+65.9%	USD	10-K	2025-02-14
Annual	2024-12-31	60099000000.0	-7.0%	USD	10-K	2026-02-13
Annual	2025-12-31	54604000000.0	-9.1%	USD	10-K	2026-02-13

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	156000000.0	—	USD	10-Q	2017-04-27
Quarterly	2016-06-30	344000000.0	+120.5%	USD	10-Q	2017-07-26
Quarterly	2016-09-30	511000000.0	+48.5%	USD	10-Q	2017-10-26
Quarterly	2017-03-31	168000000.0	-67.1%	USD	10-Q	2018-04-25
Quarterly	2017-06-30	353000000.0	+110.1%	USD	10-Q	2018-07-27
Quarterly	2017-09-30	511000000.0	+44.8%	USD	10-Q	2018-10-31
Quarterly	2018-03-31	155000000.0	-69.7%	USD	10-Q	2019-05-01
Quarterly	2018-06-30	342000000.0	+120.6%	USD	10-Q	2019-07-31
Quarterly	2018-09-30	513000000.0	+50.0%	USD	10-Q	2019-10-30
Quarterly	2019-03-31	116000000.0	-77.4%	USD	10-Q	2020-05-01
Quarterly	2019-06-30	260000000.0	+124.1%	USD	10-Q	2020-07-29
Quarterly	2019-09-30	430000000.0	+65.4%	USD	10-Q	2020-10-29
Quarterly	2020-03-31	142000000.0	-67.0%	USD	10-Q	2021-04-28
Quarterly	2020-06-30	300000000.0	+111.3%	USD	10-Q	2021-08-04
Quarterly	2020-09-30	435000000.0	+45.0%	USD	10-Q	2021-11-03
Quarterly	2021-03-31	166000000.0	-61.8%	USD	10-Q	2022-04-28
Quarterly	2021-06-30	351000000.0	+111.4%	USD	10-Q	2022-08-05
Quarterly	2021-09-30	593000000.0	+68.9%	USD	10-Q	2022-11-04
Quarterly	2022-03-31	190000000.0	-68.0%	USD	10-Q	2023-04-28
Quarterly	2022-06-30	436000000.0	+129.5%	USD	10-Q	2023-08-04
Quarterly	2022-09-30	596000000.0	+36.7%	USD	10-Q	2023-10-31
Quarterly	2023-03-31	344000000.0	-42.3%	USD	10-Q	2024-05-03
Quarterly	2023-06-30	615000000.0	+78.8%	USD	10-Q	2024-08-07
Quarterly	2023-09-30	863000000.0	+40.3%	USD	10-Q	2024-10-31
Quarterly	2024-03-31	230000000.0	-73.3%	USD	10-Q	2025-05-02
Quarterly	2024-06-30	468000000.0	+103.5%	USD	10-Q	2025-08-06
Quarterly	2024-09-30	725000000.0	+54.9%	USD	10-Q	2025-11-05
Quarterly	2025-03-31	411000000.0	-43.3%	USD	10-Q	2025-05-02
Quarterly	2025-06-30	780000000.0	+89.8%	USD	10-Q	2025-08-06
Quarterly	2025-09-30	1216000000.0	+55.9%	USD	10-Q	2025-11-05
Annual	2016-12-31	738000000.0	—	USD	10-K	2019-02-13
Annual	2017-12-31	664000000.0	-10.0%	USD	10-K	2020-02-12
Annual	2018-12-31	738000000.0	+11.1%	USD	10-K	2021-02-09
Annual	2019-12-31	618000000.0	-16.3%	USD	10-K	2022-02-16
Annual	2020-12-31	608000000.0	-1.6%	USD	10-K	2023-02-09
Annual	2021-12-31	880000000.0	+44.7%	USD	10-K	2024-02-14
Annual	2022-12-31	936000000.0	+6.4%	USD	10-K	2025-02-14
Annual	2023-12-31	1112000000.0	+18.8%	USD	10-K	2026-02-13
Annual	2024-12-31	1096000000.0	-1.4%	USD	10-K	2026-02-13
Annual	2025-12-31	1858000000.0	+69.5%	USD	10-K	2026-02-13

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	760000000.0	—	shares	10-Q	2017-04-27
Quarterly	2016-06-30	756000000.0	-0.5%	shares	10-Q	2017-07-26
Quarterly	2016-09-30	753000000.0	-0.4%	shares	10-Q	2017-10-26
Quarterly	2017-03-31	741000000.0	-1.6%	shares	10-Q	2018-04-25
Quarterly	2017-06-30	738000000.0	-0.4%	shares	10-Q	2018-07-27
Quarterly	2017-09-30	733000000.0	-0.7%	shares	10-Q	2018-10-31
Quarterly	2018-03-31	711000000.0	-3.0%	shares	10-Q	2019-05-01
Quarterly	2018-06-30	660000000.0	-7.2%	shares	10-Q	2019-07-31
Quarterly	2018-09-30	649000000.0	-1.7%	shares	10-Q	2019-10-30
Quarterly	2019-03-31	626000000.0	-3.5%	shares	10-Q	2020-05-01
Quarterly	2019-06-30	610000000.0	-2.6%	shares	10-Q	2020-07-29
Quarterly	2019-09-30	602000000.0	-1.3%	shares	10-Q	2020-10-29
Quarterly	2020-03-31	594000000.0	-1.3%	shares	10-Q	2021-04-28
Quarterly	2020-06-30	592000000.0	-0.3%	shares	10-Q	2021-08-04
Quarterly	2020-09-30	589000000.0	-0.5%	shares	10-Q	2021-11-03
Quarterly	2021-03-31	581000000.0	-1.4%	shares	10-Q	2022-04-28
Quarterly	2021-06-30	576000000.0	-0.9%	shares	10-Q	2022-08-05
Quarterly	2021-09-30	570000000.0	-1.0%	shares	10-Q	2022-11-04
Quarterly	2022-03-31	551000000.0	-3.3%	shares	10-Q	2023-04-28
Quarterly	2022-06-30	537000000.0	-2.5%	shares	10-Q	2023-08-04
Quarterly	2022-09-30	538000000.0	+0.2%	shares	10-Q	2023-10-31
Quarterly	2023-03-31	538000000.0	+0.0%	shares	10-Q	2024-05-03
Quarterly	2023-06-30	537000000.0	-0.2%	shares	10-Q	2024-08-07
Quarterly	2023-09-30	538000000.0	+0.2%	shares	10-Q	2024-10-31
Quarterly	2024-03-31	536000000.0	-0.4%	shares	10-Q	2025-05-02
Quarterly	2024-06-30	541000000.0	+0.9%	shares	10-Q	2025-08-06
Quarterly	2024-09-30	542000000.0	+0.2%	shares	10-Q	2025-11-05
Quarterly	2025-03-31	541000000.0	-0.2%	shares	10-Q	2025-05-02
Quarterly	2025-06-30	541000000.0	+0.0%	shares	10-Q	2025-08-06
Quarterly	2025-09-30	542000000.0	+0.2%	shares	10-Q	2025-11-05
Annual	2016-12-31	754000000.0	—	shares	10-K	2019-02-13
Annual	2017-12-31	735000000.0	-2.5%	shares	10-K	2020-02-12
Annual	2018-12-31	665000000.0	-9.5%	shares	10-K	2021-02-09
Annual	2019-12-31	609000000.0	-8.4%	shares	10-K	2022-02-16
Annual	2020-12-31	590000000.0	-3.1%	shares	10-K	2023-02-09
Annual	2021-12-31	573000000.0	-2.9%	shares	10-K	2024-02-14
Annual	2022-12-31	541000000.0	-5.6%	shares	10-K	2025-02-14
Annual	2023-12-31	538000000.0	-0.6%	shares	10-K	2026-02-13
Annual	2024-12-31	541000000.0	+0.6%	shares	10-K	2026-02-13
Annual	2025-12-31	542000000.0	+0.2%	shares	10-K	2026-02-13

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

54,604,000,000

Total Liabilities (latest annual)

N/A

Current Liabilities (latest annual)

25,489,000,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	0.0662	—	ratio	10-Q	2017-04-27
Quarterly	2016-06-30	0.0621	-6.3%	ratio	10-Q	2017-07-26
Quarterly	2016-09-30	0.0655	+5.6%	ratio	10-Q	2017-10-26
Quarterly	2017-03-31	0.0676	+3.1%	ratio	10-Q	2018-04-25
Quarterly	2017-06-30	0.0678	+0.3%	ratio	10-Q	2018-07-27
Quarterly	2017-09-30	0.0627	-7.5%	ratio	10-Q	2018-10-31
Quarterly	2018-03-31	0.1480	+135.9%	ratio	10-Q	2019-10-30
Quarterly	2018-06-30	0.1540	+4.1%	ratio	10-Q	2019-10-30
Quarterly	2018-09-30	0.1296	-15.9%	ratio	10-Q	2019-10-30
Quarterly	2019-03-31	0.1839	+41.9%	ratio	10-Q	2020-10-29
Quarterly	2019-06-30	0.2019	+9.8%	ratio	10-Q	2020-10-29
Quarterly	2019-09-30	0.1801	-10.8%	ratio	10-Q	2020-10-29
Quarterly	2020-03-31	0.1924	+6.8%	ratio	10-Q	2021-11-03
Quarterly	2020-06-30	0.1692	-12.1%	ratio	10-Q	2021-11-03
Quarterly	2020-09-30	0.1844	+9.0%	ratio	10-Q	2021-11-03
Quarterly	2021-03-31	0.1763	-4.4%	ratio	10-Q	2022-11-04
Quarterly	2021-06-30	0.0563	-68.1%	ratio	10-Q	2022-11-04
Quarterly	2021-09-30	0.2293	+307.5%	ratio	10-Q	2022-11-04
Quarterly	2022-03-31	1.6114	+602.8%	ratio	10-Q	2023-10-31
Quarterly	2022-06-30	0.5444	-66.2%	ratio	10-Q	2023-10-31
Quarterly	2022-09-30	0.5866	+7.8%	ratio	10-Q	2023-10-31
Quarterly	2023-03-31	0.5312	-9.4%	ratio	10-Q	2024-10-31
Quarterly	2023-06-30	0.2034	-61.7%	ratio	10-Q	2024-10-31
Quarterly	2023-09-30	0.2260	+11.1%	ratio	10-Q	2024-10-31
Quarterly	2024-03-31	-0.0225	-110.0%	ratio	10-Q	2025-05-02
Quarterly	2024-06-30	0.1259	+659.6%	ratio	10-Q	2025-08-06
Quarterly	2024-09-30	0.3760	+198.6%	ratio	10-Q	2025-11-05
Quarterly	2025-03-31	0.2787	-25.9%	ratio	10-Q	2025-05-02
Quarterly	2025-06-30	0.1928	-30.8%	ratio	10-Q	2025-08-06
Quarterly	2025-09-30	0.3343	+73.4%	ratio	10-Q	2025-11-05
Annual	2016-12-31	0.2585	—	ratio	10-K	2019-02-13
Annual	2017-12-31	0.0784	-69.7%	ratio	10-K	2020-02-12
Annual	2018-12-31	0.6715	+756.5%	ratio	10-K	2021-02-09
Annual	2019-12-31	0.8107	+20.7%	ratio	10-K	2022-02-16
Annual	2020-12-31	0.7720	-4.8%	ratio	10-K	2023-02-09
Annual	2021-12-31	0.8796	+13.9%	ratio	10-K	2024-02-14
Annual	2022-12-31	1.7897	+103.5%	ratio	10-K	2025-02-14
Annual	2023-12-31	1.0778	-39.8%	ratio	10-K	2026-02-13
Annual	2024-12-31	0.6959	-35.4%	ratio	10-K	2026-02-13
Annual	2025-12-31	0.8906	+28.0%	ratio	10-K	2026-02-13

8-K Material Event Details

55 filings · 113 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

281 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-03-16	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	5,621	$366.21	$2,058,466	82,404
2026-03-04	Bradway Robert A	Chairman, CEO and President	Exercise / conversion M · derivative	Nqso (Right to Buy)	119,782	$0.00	$0	0
2026-03-04	Bradway Robert A	Chairman, CEO and President	Other disposed transaction F	Common Stock	84,285	$379.27	$31,966,772	492,643
2026-03-04	Bradway Robert A	Chairman, CEO and President	Exercise / conversion M	Common Stock	119,782	$156.35	$18,727,916	576,928
2026-03-03	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	11,259	$0.00	$0	87,877
2026-02-26	Santos Esteban	EVP, Operations	Exercise / conversion M · derivative	Nqso (Right to Buy)	24,291	$0.00	$0	0
2026-02-26	Santos Esteban	EVP, Operations	Exercise / conversion M · derivative	Nqso (Right to Buy)	30,501	$0.00	$0	0
2026-02-26	Santos Esteban	EVP, Operations	Open-market sell S	Common Stock	24,291	$379.12	$9,209,138	76,618
2026-02-26	Santos Esteban	EVP, Operations	Exercise / conversion M	Common Stock	24,291	$177.46	$4,310,681	100,909
2026-02-26	Santos Esteban	EVP, Operations	Open-market sell S	Common Stock	30,501	$379.12	$11,563,457	76,618
2026-02-26	Santos Esteban	EVP, Operations	Exercise / conversion M	Common Stock	30,501	$162.60	$4,959,463	107,119
2026-02-19	Busch Matthew C.	VP, Finance & CAO	Open-market sell S	Common Stock	1,000	$375.79	$375,790	3,423
2026-02-09	Bradner James E.	EVP, Research and Development	Other disposed transaction F	Common Stock	953	$384.32	$366,257	27,378
2026-02-09	Bradner James E.	EVP, Research and Development	Other disposed transaction F	Common Stock	2,151	$384.32	$826,672	28,331
2025-11-20	Grygiel Nancy A.	SVP & CCO	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,639	$0.00	$0	0
2025-11-20	Grygiel Nancy A.	SVP & CCO	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,500	$0.00	$0	1,970
2025-11-20	Grygiel Nancy A.	SVP & CCO	Open-market sell S	Common Stock	1,639	$337.26	$552,773	7,225
2025-11-20	Grygiel Nancy A.	SVP & CCO	Exercise / conversion M	Common Stock	1,639	$162.60	$266,501	8,864
2025-11-20	Grygiel Nancy A.	SVP & CCO	Open-market sell S	Common Stock	1,500	$337.26	$505,894	7,225
2025-11-20	Grygiel Nancy A.	SVP & CCO	Exercise / conversion M	Common Stock	1,500	$177.46	$266,190	8,725
2025-11-12	REESE DAVID M	EVP & Chief Technology Officer	Equity grant / award G	Common Stock	309	$0.00	$0	35,503
2025-11-12	Khosla Rachna	SVP, Business Development	Open-market sell S	Common Stock	890	$336.24	$299,256	7,082
2025-11-11	REESE DAVID M	EVP & Chief Technology Officer	Equity grant / award G	Common Stock	6,490	$0.00	$0	35,812
2025-11-07	ISHRAK OMAR	Dir	Equity grant / award A	Common Stock	219	$0.00	$0	6,508
2025-11-05	Khosla Rachna	SVP, Business Development	Other disposed transaction F	Common Stock	226	$296.70	$67,054	7,972
2025-08-20	Grygiel Nancy A.	SVP & CCO	Open-market sell S	Common Stock	1,267	$296.99	$376,280	7,209
2025-08-08	ISHRAK OMAR	Dir	Equity grant / award A	Common Stock	121	$0.00	$0	6,242
2025-06-05	Khosla Rachna	SVP, Business Development	Open-market sell S	Common Stock	1,500	$289.68	$434,520	8,162
2025-05-23	MILES AMY E	Dir	Equity grant / award A	Common Stock	809	$0.00	$0	4,842
2025-05-06	Bradway Robert A	Chairman, CEO and President	Equity grant / award A · derivative	Nqso (Right to Buy)	86,042	$270.44	$23,269,198	86,042
2025-05-06	Bradway Robert A	Chairman, CEO and President	Equity grant / award A	Common Stock	13,311	$0.00	$0	413,499
2025-05-02	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	621	$283.78	$176,227	73,040
2025-05-02	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	655	$283.78	$185,876	73,661
2025-04-30	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	759	$288.56	$219,017	74,316
2025-03-17	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	3,393	$313.71	$1,064,418	75,075
2025-03-03	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	6,792	$0.00	$0	78,338
2025-02-19	Miller Derek	SVP, Human Resources	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,524	$0.00	$0	0
2025-02-19	Miller Derek	SVP, Human Resources	Open-market sell S	Common Stock	1,524	$293.74	$447,655	8,544
2025-02-19	Miller Derek	SVP, Human Resources	Exercise / conversion M	Common Stock	1,524	$156.35	$238,277	10,068
2025-02-19	Santos Esteban	EVP, Operations	Exercise / conversion M · derivative	Nqso (Right to Buy)	8,711	$0.00	$0	0
2025-02-19	Santos Esteban	EVP, Operations	Open-market sell S	Common Stock	8,711	$292.84	$2,550,903	71,546
2025-02-19	Santos Esteban	EVP, Operations	Exercise / conversion M	Common Stock	8,711	$156.35	$1,361,965	80,257
2025-02-18	Miller Derek	SVP, Human Resources	Open-market sell S	Common Stock	500	$292.56	$146,279	8,544
2025-02-11	Gordon Murdo	EVP, Global Commercial Ops	Open-market sell S	Common Stock	8,771	$294.79	$2,585,644	44,186
2025-02-07	Graham Jonathan P	EVP & Gen. Counsel & Secy.	Exercise / conversion M · derivative	Nqso (Right to Buy)	25,045	$0.00	$0	0
2025-02-07	Graham Jonathan P	EVP & Gen. Counsel & Secy.	Open-market sell S	Common Stock	25,045	$293.12	$7,341,123	28,987
2025-02-07	Graham Jonathan P	EVP & Gen. Counsel & Secy.	Exercise / conversion M	Common Stock	25,045	$156.35	$3,915,786	54,032
2025-02-05	Grygiel Nancy A.	SVP & CCO	Open-market sell S	Common Stock	1,589	$304.47	$483,808	7,210
2024-12-05	Graham Jonathan P	EVP & Gen. Counsel & Secy.	Equity grant / award G	Common Stock	6,430	$0.00	$0	28,903
2024-12-02	Bradway Robert A	Chairman, CEO and President	Equity grant / award G	Common Stock	90,000	$0.00	$0	393,855
2024-12-02	Bradway Robert A	Chairman, CEO and President	Equity grant / award G	Common Stock	96,000	$0.00	$0	573,855
2024-11-05	Khosla Rachna	SVP, Business Development	Other disposed transaction F	Common Stock	212	$316.91	$67,185	8,383
2024-11-04	ISHRAK OMAR	Dir	Equity grant / award A	Common Stock	221	$0.00	$0	5,081
2024-08-09	ISHRAK OMAR	Dir	Equity grant / award A	Common Stock	109	$0.00	$0	4,833
2024-07-31	Grygiel Nancy A.	SVP & CCO	Other disposed transaction F	Common Stock	1,565	$333.28	$521,583	8,771
2024-05-31	MILES AMY E	Dir	Equity grant / award A	Common Stock	719	$0.00	$0	3,927
2024-05-07	Santos Esteban	EVP, Operations	Equity grant / award A · derivative	Nqso (Right to Buy)	19,469	$300.30	$5,846,541	38,938
2024-05-07	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	2,997	$300.30	$899,999	71,304
2024-05-05	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	617	$311.29	$192,066	68,307
2024-05-03	Grygiel Nancy A.	SVP & CCO	Open-market sell S	Common Stock	2,117	$313.09	$662,802	9,883
2024-05-02	Khosla Rachna	SVP, Business Development	Other disposed transaction F	Common Stock	74	$277.37	$20,525	8,068
2024-04-30	Miller Derek	SVP, Human Resources	Other disposed transaction F	Common Stock	71	$276.38	$19,623	8,348
2024-03-18	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	6,137	$268.87	$1,650,055	70,213
2024-03-06	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	12,278	$0.00	$0	76,125
2024-02-09	Bradner James E.	EVP, R&D, & Chief Sci. Officer	Equity grant / award A	Common Stock	13,806	$0.00	$0	22,393
2024-02-09	Bradner James E.	EVP, R&D, & Chief Sci. Officer	Equity grant / award A	Common Stock	8,587	$0.00	$0	8,587
2023-12-04	Grygiel Nancy A.	SVP & CCO	Open-market sell S	Common Stock	2,096	$273.03	$572,276	10,874
2023-11-28	REESE DAVID M	EVP, Research and Development	Equity grant / award G	Common Stock	165	$0.00	$0	54,164
2023-11-08	Graham Jonathan P	EVP, Gen. Counsel & Secy.	Open-market sell S	Common Stock	10,000	$272.81	$2,728,136	28,078
2023-11-05	Miller Derek	SVP, Human Resources	Other disposed transaction F	Common Stock	66	$269.86	$17,811	7,533
2023-11-03	ISHRAK OMAR	Dir	Equity grant / award A	Common Stock	241	$0.00	$0	3,813
2023-11-01	Griffith Peter H.	EVP & CFO	Other disposed transaction F	Common Stock	3,502	$255.70	$895,461	28,820
2023-09-19	AMGEN INC	—	Exercise / conversion C · derivative	Series B Preferred Stock	849,657	—	—	0
2023-09-19	AMGEN INC	—	Exercise / conversion C · derivative	Series A-2 Preferred Stock	32,754,291	—	—	0
2023-09-19	AMGEN INC	—	Open-market buy P	Common Stock	1,764,705	$17.00	$29,999,985	35,368,653
2023-09-19	AMGEN INC	—	Exercise / conversion C	Common Stock	33,603,948	—	—	33,603,948
2023-08-10	Gordon Murdo	EVP, Global Commercial Ops	Open-market sell S	Common Stock	9,558	$262.43	$2,508,306	44,308
2023-08-08	HOLLEY CHARLES M	Dir	Equity grant / award A	Common Stock	153	$0.00	$0	8,132
2023-07-31	Grygiel Nancy A.	SVP & CCO	Other disposed transaction F	Common Stock	1,129	$236.37	$266,862	13,095
2023-05-19	Williams R Sanders	Dir	Equity grant / award A	Common Stock	939	$0.00	$0	6,240
2023-05-05	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	579	$231.89	$134,264	63,582
2023-05-03	Grygiel Nancy A.	SVP & CCO	Other disposed transaction F	Common Stock	62	$235.97	$14,630	14,278
2023-05-02	Grygiel Nancy A.	SVP & CCO	Equity grant / award A · derivative	Nqso (Right to Buy)	5,375	$0.00	$0	5,375
2023-05-02	Grygiel Nancy A.	SVP & CCO	Equity grant / award A	Common Stock	635	$0.00	$0	14,340
2023-04-30	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	660	$239.74	$158,228	61,318
2023-03-17	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	3,881	$234.57	$910,366	61,978
2023-03-06	Bradway Robert A	Chairman, CEO and President	Equity grant / award A	Common Stock	27,915	$0.00	$0	648,712
2022-11-09	Khosla Rachna	SVP, Business Development	Open-market sell S	Common Stock	387	$292.90	$113,352	6,630
2022-11-08	Kullman Ellen Jamison	Dir	Equity grant / award A	Common Stock	222	$0.00	$0	10,113
2022-11-05	Miller Derek	SVP, Human Resources	Other disposed transaction F	Common Stock	63	$269.04	$16,950	5,973
2022-11-02	REESE DAVID M	EVP, Research and Development	Other disposed transaction F	Common Stock	2,440	$272.06	$663,826	48,136
2022-11-01	Griffith Peter H.	EVP & CFO	Other disposed transaction F	Common Stock	3,030	$270.35	$819,160	24,675
2022-08-22	Gordon Murdo	EVP Global Commercial Ops	Equity grant / award G	Common Stock	400	$0.00	$0	47,484
2022-08-18	ECKERT ROBERT	Dir	Open-market sell S	Common Stock	6,600	$249.00	$1,643,378	21,184
2022-08-10	ECKERT ROBERT	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	20,000	$0.00	$0	0
2022-08-10	ECKERT ROBERT	Dir	Other disposed transaction F	Common Stock	6,791	$252.09	$1,711,943	27,784
2022-08-10	ECKERT ROBERT	Dir	Exercise / conversion M	Common Stock	20,000	$85.59	$1,711,800	34,575
2022-08-09	Kullman Ellen Jamison	Dir	Equity grant / award A	Common Stock	131	$0.00	$0	9,815
2022-07-31	Khosla Rachna	SVP, Business Development	Other disposed transaction F	Common Stock	217	$247.47	$53,701	7,158
2022-05-23	Williams R Sanders	Dir	Open-market sell S	Common Stock	600	$250.00	$150,000	5,501
2022-05-17	Williams R Sanders	Dir	Equity grant / award A	Common Stock	855	$0.00	$0	6,101
2022-05-12	Graham Jonathan P	EVP, Gen. Counsel & Secy.	Equity grant / award G	Common Stock	2,000	$0.00	$0	35,333
2022-05-10	Graham Jonathan P	EVP, Gen. Counsel & Secy.	Open-market sell S	Common Stock	13,500	$241.81	$3,264,454	37,333
2022-05-05	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	589	$236.10	$139,063	57,661
2022-05-03	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	708	$230.92	$163,491	58,250
2022-05-02	Santos Esteban	EVP, Operations	Equity grant / award A · derivative	Nqso (Right to Buy)	29,695	$0.00	$0	29,695
2022-05-02	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	3,637	$0.00	$0	58,958
2022-04-27	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	599	$249.87	$149,672	55,321
2022-03-18	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	4,370	$235.86	$1,030,708	55,920
2022-03-01	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	8,740	$0.00	$0	60,119
2022-01-11	AMGEN INC	10%	Exercise / conversion C · derivative	Series A Preferred Stock	3,206,281	$0.00	$0	0
2022-01-11	AMGEN INC	10%	Exercise / conversion C	Common Stock	3,206,281	—	—	3,206,281
2021-11-05	Kullman Ellen Jamison	Dir	Equity grant / award A	Common Stock	152	$0.00	$0	8,477
2021-11-02	REESE DAVID M	EVP, Research and Development	Other disposed transaction F	Common Stock	2,192	$209.74	$459,750	42,593
2021-11-01	Johnston Lori A	EVP, HR	Other disposed transaction F	Common Stock	1,352	$206.97	$279,823	36,269
2021-08-06	Kullman Ellen Jamison	Dir	Equity grant / award A	Common Stock	282	$0.00	$0	8,263
2021-05-18	Druker Brian	Dir	Equity grant / award A	Common Stock	837	$0.00	$0	3,634
2021-05-12	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,000	$0.00	$0	0
2021-05-12	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	1,000	$250.59	$250,590	15,927
2021-05-12	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	1,000	$71.64	$71,640	16,927
2021-05-11	Grygiel Nancy A.	SVP & CCO	Exercise / conversion M · derivative	Nqso (Right to Buy)	2,500	$0.00	$0	1,639
2021-05-11	Grygiel Nancy A.	SVP & CCO	Open-market sell S	Common Stock	2,500	$252.51	$631,272	12,461
2021-05-11	Grygiel Nancy A.	SVP & CCO	Exercise / conversion M	Common Stock	2,500	$162.60	$406,500	14,961
2021-05-07	Williams R Sanders	Dir	Open-market sell S	Common Stock	250	$251.78	$62,945	4,409
2021-05-03	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	685	$239.64	$164,153	51,108
2021-05-01	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	651	$239.64	$156,006	51,793
2021-04-30	Santos Esteban	EVP, Operations	Equity grant / award A · derivative	Nqso (Right to Buy)	34,420	$0.00	$0	34,420
2021-04-30	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	3,964	$0.00	$0	52,444
2021-04-27	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	564	$255.52	$144,113	48,480
2021-04-14	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,000	$0.00	$0	1,000
2021-04-14	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	1,000	$249.98	$249,980	15,927
2021-04-14	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	1,000	$71.64	$71,640	16,927
2021-03-19	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	4,360	$244.42	$1,065,671	49,044
2021-03-10	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,000	$0.00	$0	2,000
2021-03-10	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	1,000	$231.53	$231,530	15,805
2021-03-10	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	1,000	$71.64	$71,640	16,805
2021-03-02	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	8,725	$0.00	$0	53,251
2021-02-18	Bradway Robert A	Chairman, CEO and President	Exercise / conversion M · derivative	Nqso (Right to Buy)	73,500	$0.00	$0	0
2021-02-18	Bradway Robert A	Chairman, CEO and President	Other disposed transaction F	Common Stock	47,527	$235.61	$11,197,836	570,853
2021-02-18	Bradway Robert A	Chairman, CEO and President	Exercise / conversion M	Common Stock	73,500	$54.69	$4,019,715	618,380
2021-02-16	REESE DAVID M	EVP, Research and Development	Exercise / conversion M · derivative	Nqso (Right to Buy)	2,300	$0.00	$0	0
2021-02-16	REESE DAVID M	EVP, Research and Development	Other disposed transaction F	Common Stock	1,147	$237.21	$272,080	40,912
2021-02-16	REESE DAVID M	EVP, Research and Development	Exercise / conversion M	Common Stock	2,300	$54.69	$125,787	42,059
2021-02-10	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,000	$0.00	$0	3,000
2021-02-10	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	1,000	$238.40	$238,400	15,805
2021-02-10	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	1,000	$71.64	$71,640	16,805
2021-02-08	Williams R Sanders	Dir	Open-market sell S	Common Stock	250	$237.99	$59,498	4,659
2021-02-07	Johnston Lori A	EVP, HR	Other disposed transaction F	Common Stock	474	$236.32	$112,016	32,074
2021-02-05	Kullman Ellen Jamison	Dir	Equity grant / award A	Common Stock	17	$0.00	$0	6,908
2021-02-04	Graham Jonathan P	EVP, Gen. Counsel & Secy.	Open-market sell S	Common Stock	11,110	$236.51	$2,627,625	39,945
2021-01-13	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,000	$0.00	$0	4,000
2021-01-13	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	1,000	$235.99	$235,990	15,805
2021-01-13	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	1,000	$71.64	$71,640	16,805
2020-11-09	Williams R Sanders	Dir	Open-market sell S	Common Stock	250	$242.40	$60,600	4,909
2020-11-02	REESE DAVID M	EVP, Research and Development	Other disposed transaction F	Common Stock	2,125	$216.94	$460,998	39,619
2020-08-19	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,000	$0.00	$0	5,000
2020-08-19	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	1,000	$241.02	$241,020	15,589
2020-08-19	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	1,000	$54.69	$54,690	16,589
2020-08-07	Williams R Sanders	Dir	Open-market sell S	Common Stock	250	$242.95	$60,738	5,159
2020-08-03	Grygiel Nancy A.	SVP & CCO	Other disposed transaction F	Common Stock	290	$244.67	$70,954	11,026
2020-08-01	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	2,165	$244.67	$529,711	44,376
2020-07-31	Grygiel Nancy A.	SVP & CCO	Equity grant / award A	Common Stock	8,174	$0.00	$0	11,316
2020-07-22	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,000	$0.00	$0	6,000
2020-07-22	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	1,000	$259.79	$259,790	15,589
2020-07-22	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	1,000	$54.69	$54,690	16,589
2020-07-15	AMGEN INC	10%	Equity grant / award A	Ordinary Shares	29,614,832	$14.23	$421,442,751	236,249,845
2020-06-17	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,000	$0.00	$0	7,000
2020-06-17	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	1,000	$228.54	$228,540	15,576
2020-06-17	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	1,000	$54.69	$54,690	16,576
2020-05-20	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,000	$0.00	$0	8,000
2020-05-20	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	1,000	$229.27	$229,270	15,482
2020-05-20	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	1,000	$54.69	$54,690	16,482
2020-05-05	Santos Esteban	EVP, Operations	Equity grant / award A · derivative	Nqso (Right to Buy)	28,341	$0.00	$0	28,341
2020-05-05	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	3,384	$0.00	$0	46,433
2020-05-03	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	194	$230.98	$44,810	43,049
2020-05-01	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	593	$239.22	$141,857	43,243
2020-04-27	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	526	$236.28	$124,283	43,836
2020-04-22	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,000	$0.00	$0	9,000
2020-04-22	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	1,000	$233.35	$233,350	14,636
2020-04-22	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	1,000	$54.69	$54,690	15,636
2020-04-13	Bradway Robert A	Chairman, CEO and President	Exercise / conversion M · derivative	Nqso (Right to Buy)	84,000	$0.00	$0	0
2020-04-13	Bradway Robert A	Chairman, CEO and President	Exercise / conversion M · derivative	Nqso (Right to Buy)	43,000	$0.00	$0	0
2020-04-13	Bradway Robert A	Chairman, CEO and President	Other disposed transaction F	Common Stock	55,695	$218.21	$12,153,206	539,821
2020-04-13	Bradway Robert A	Chairman, CEO and President	Exercise / conversion M	Common Stock	84,000	$58.43	$4,908,120	595,516
2020-04-13	Bradway Robert A	Chairman, CEO and President	Other disposed transaction F	Common Stock	28,511	$218.21	$6,221,385	511,516
2020-04-13	Bradway Robert A	Chairman, CEO and President	Exercise / conversion M	Common Stock	43,000	$58.43	$2,512,490	540,027
2020-03-20	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	6,465	$198.76	$1,284,983	44,362
2020-03-09	REESE DAVID M	EVP, Research and Development	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,480	$0.00	$0	0
2020-03-09	REESE DAVID M	EVP, Research and Development	Other disposed transaction F	Common Stock	780	$210.65	$164,307	40,985
2020-03-09	REESE DAVID M	EVP, Research and Development	Exercise / conversion M	Common Stock	1,480	$58.43	$86,476	41,765
2020-03-03	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	12,991	$0.00	$0	50,618
2020-02-07	Johnston Lori A	EVP, HR	Other disposed transaction F	Common Stock	462	$231.45	$106,930	26,094
2020-02-06	Williams R Sanders	Dir	Open-market sell S	Common Stock	425	$233.72	$99,331	4,988
2020-02-04	HOLLEY CHARLES M	Dir	Equity grant / award A	Common Stock	14	$0.00	$0	3,106
2019-12-13	Piacquad David	SVP, Business Development	Exercise / conversion M · derivative	Nqso (Right to Buy)	2,875	$0.00	$0	5,839
2019-12-13	Piacquad David	SVP, Business Development	Other disposed transaction F	Common Stock	2,425	$235.99	$572,276	48,964
2019-12-13	Piacquad David	SVP, Business Development	Exercise / conversion M	Common Stock	2,875	$162.60	$467,475	51,389
2019-11-25	Meline David W	EVP & CFO	Open-market sell S	Common Stock	8,737	$234.36	$2,047,603	49,378
2019-11-22	Graham Jonathan P	EVP, Gen. Counsel & Secy.	Open-market sell S	Common Stock	9,000	$230.54	$2,074,837	42,853
2019-11-20	Piacquad David	SVP, Business Development	Exercise / conversion M · derivative	Nqso (Right to Buy)	5,749	$0.00	$0	2,962
2019-11-20	Piacquad David	SVP, Business Development	Other disposed transaction F	Common Stock	4,870	$224.50	$1,093,315	48,491
2019-11-20	Piacquad David	SVP, Business Development	Exercise / conversion M	Common Stock	5,749	$156.35	$898,856	53,361
2019-11-06	Williams R Sanders	Dir	Open-market sell S	Common Stock	425	$215.45	$91,566	5,413
2019-11-02	Gordon Murdo	EVP Global Commercial Ops	Other disposed transaction F	Common Stock	5,812	$217.95	$1,266,725	34,024
2019-11-01	Johnston Lori A	EVP, HR	Equity grant / award A	Common Stock	7,799	$0.00	$0	26,457
2019-10-02	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	2,000	$0.00	$0	2,000
2019-10-02	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	2,000	$193.58	$387,160	14,436
2019-10-02	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	2,000	$54.71	$109,420	16,436
2019-09-04	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	2,000	$0.00	$0	4,000
2019-09-04	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	2,000	$206.70	$413,400	14,336
2019-09-04	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	2,000	$54.71	$109,420	16,336
2019-08-30	Patton Cynthia M	SVP & CCO	Exercise / conversion M · derivative	Nqso (Right to Buy)	2,875	$0.00	$0	5,839
2019-08-30	Patton Cynthia M	SVP & CCO	Exercise / conversion M · derivative	Nqso (Right to Buy)	5,749	$0.00	$0	2,962
2019-08-30	Patton Cynthia M	SVP & CCO	Open-market sell S	Common Stock	4,802	$208.07	$999,139	22,097
2019-08-30	Patton Cynthia M	SVP & CCO	Open-market sell S	Common Stock	2,875	$208.07	$598,193	26,899
2019-08-30	Patton Cynthia M	SVP & CCO	Exercise / conversion M	Common Stock	2,875	$162.60	$467,475	29,774
2019-08-30	Patton Cynthia M	SVP & CCO	Open-market sell S	Common Stock	5,749	$208.07	$1,196,178	26,899
2019-08-30	Patton Cynthia M	SVP & CCO	Exercise / conversion M	Common Stock	5,749	$156.35	$898,856	32,648
2019-08-07	Williams R Sanders	Dir	Open-market sell S	Common Stock	425	$183.04	$77,792	5,838
2019-08-04	Graham Jonathan P	SVP, Gen. Counsel & Secy.	Other disposed transaction F	Common Stock	6,785	$187.22	$1,270,288	42,610
2019-08-02	Kullman Ellen Jamison	Dir	Equity grant / award A	Common Stock	160	$0.00	$0	5,041
2019-08-01	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	2,043	$186.58	$381,183	37,437
2019-07-03	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	2,000	$0.00	$0	8,000
2019-07-03	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	2,000	$187.58	$375,160	14,336
2019-07-03	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	2,000	$54.71	$109,420	16,336
2019-06-05	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	2,000	$0.00	$0	10,000
2019-06-05	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	2,000	$175.68	$351,360	14,219
2019-06-05	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	2,000	$54.71	$109,420	16,219
2019-05-03	Santos Esteban	EVP, Operations	Equity grant / award A · derivative	Iso (Right to Buy)	34,460	$0.00	$0	34,460
2019-05-03	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	3,947	$0.00	$0	39,329
2019-05-03	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	182	$176.50	$32,123	35,382
2019-05-01	Piacquad David	SVP, Business Development	Other disposed transaction F	Common Stock	171	$179.32	$30,664	46,046
2019-04-03	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	2,000	$0.00	$0	14,000
2019-04-03	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	2,000	$193.18	$386,360	13,092
2019-04-03	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	2,000	$54.71	$109,420	15,092
2019-03-22	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	1,838	$191.89	$352,694	36,161
2019-03-06	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	2,000	$0.00	$0	14,988
2019-03-06	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	2,000	$188.88	$377,760	12,988
2019-03-06	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	2,000	$54.71	$109,420	14,988
2019-02-07	SUGAR RONALD D	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	2,000	$0.00	$0	18,000
2019-02-07	SUGAR RONALD D	Dir	Open-market sell S	Common Stock	2,000	$190.00	$380,000	12,988
2019-02-07	SUGAR RONALD D	Dir	Exercise / conversion M	Common Stock	2,000	$54.71	$109,420	14,988
2019-02-01	Kullman Ellen Jamison	Dir	Equity grant / award A	Common Stock	187	$0.00	$0	3,519
2019-01-30	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	142	$192.11	$27,280	34,700
2018-12-06	Jacks Tyler	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	20,000	$0.00	$0	0
2018-12-06	Jacks Tyler	Dir	Open-market sell S	Common Stock	20,000	$195.41	$3,908,232	8,979
2018-12-06	Jacks Tyler	Dir	Exercise / conversion M	Common Stock	20,000	$82.60	$1,652,000	28,979
2018-11-30	Piacquad David	SVP, Business Development	Exercise / conversion M · derivative	Nqso (Right to Buy)	6,500	$0.00	$0	0
2018-11-30	Piacquad David	SVP, Business Development	Other disposed transaction F	Common Stock	4,109	$202.37	$831,538	41,019
2018-11-30	Piacquad David	SVP, Business Development	Exercise / conversion M	Common Stock	6,500	$54.69	$355,485	45,128
2018-11-29	Patton Cynthia M	SVP & CCO	Exercise / conversion M · derivative	Nqso (Right to Buy)	1,777	$0.00	$0	0
2018-11-29	Patton Cynthia M	SVP & CCO	Open-market sell S	Common Stock	1,777	$202.88	$360,520	21,313
2018-11-29	Patton Cynthia M	SVP & CCO	Exercise / conversion M	Common Stock	1,777	$54.69	$97,184	23,090
2018-11-02	REESE DAVID M	EVP, Research and Development	Equity grant / award A	Common Stock	12,830	$0.00	$0	30,618
2018-08-10	HENDERSON REBECCA M	Dir	Exercise / conversion M · derivative	Nqso (Right to Buy)	3,000	$0.00	$0	0
2018-08-10	HENDERSON REBECCA M	Dir	Other disposed transaction F	Common Stock	977	$193.97	$189,509	15,220
2018-08-10	HENDERSON REBECCA M	Dir	Exercise / conversion M	Common Stock	3,000	$63.11	$189,330	16,197
2018-08-06	Graham Jonathan P	SVP, Gen. Counsel & Secy.	Other disposed transaction F	Common Stock	6,586	$197.99	$1,303,962	41,256
2018-08-01	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	1,982	$196.55	$389,562	34,654
2018-07-31	Kullman Ellen Jamison	Dir	Equity grant / award A	Common Stock	152	$0.00	$0	3,144
2018-07-16	Harper Sean E	EVP, Research & Development	Open-market sell S	Common Stock	1,525	$195.71	$298,458	56,082
2018-06-25	Onyx Therapeutics, Inc.	10%	Exercise / conversion C · derivative	Series A Redeemable Convertible Preferred Stock	1,121,384	$0.00	$0	0
2018-06-25	Onyx Therapeutics, Inc.	10%	Exercise / conversion C	Common Stock	1,121,384	—	—	1,121,384
2018-06-12	Harper Sean E	EVP, Research & Development	Open-market sell S	Common Stock	1,525	$184.27	$281,012	57,510
2018-05-14	Harper Sean E	EVP, Research & Development	Open-market sell S	Common Stock	1,525	$174.10	$265,502	59,035
2018-05-11	Piacquad David	SVP, Business Development	Exercise / conversion M · derivative	Nqso (Right to Buy)	15,000	$0.00	$0	0
2018-05-11	Piacquad David	SVP, Business Development	Other disposed transaction F	Common Stock	9,860	$170.77	$1,683,792	41,706
2018-05-11	Piacquad David	SVP, Business Development	Exercise / conversion M	Common Stock	15,000	$54.71	$820,650	51,566
2018-05-03	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	178	$169.43	$30,159	36,466
2018-04-27	Santos Esteban	EVP, Operations	Equity grant / award A · derivative	Nqso (Right to Buy)	24,291	$0.00	$0	24,291
2018-04-27	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	3,155	$0.00	$0	36,644
2018-04-25	Piacquad David	SVP, Business Development	Other disposed transaction F	Common Stock	217	$171.94	$37,311	35,787
2018-04-12	Harper Sean E	EVP, Research & Development	Open-market sell S	Common Stock	1,525	$172.68	$263,337	56,788
2018-03-23	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	1,634	$176.08	$287,715	33,489
2018-03-16	Harper Sean E	EVP, Research & Development	Open-market sell S	Common Stock	1,525	$189.75	$289,369	65,682
2018-03-07	Santos Esteban	EVP, Operations	Equity grant / award A	Common Stock	3,527	$0.00	$0	34,980
2018-02-14	Harper Sean E	EVP, Research & Development	Open-market sell S	Common Stock	1,525	$174.18	$265,624	52,089
2018-02-07	Johnston Lori A	SVP, HR	Other disposed transaction F	Common Stock	441	$176.65	$77,903	15,017
2018-02-06	Austin Wanda M	Dir	Equity grant / award A	Common Stock	94	$0.00	$0	94
2018-01-31	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	141	$191.27	$26,969	31,453
2018-01-30	Santos Esteban	EVP, Operations	Other disposed transaction F	Common Stock	133	$198.00	$26,334	31,594

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count