Financial Metrics

BMRN BIOMARIN PHARMACEUTICAL INC

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-09-30	-0.22	—	USD/shares	10-Q	2017-10-31
Quarterly	2017-03-31	-0.09	+59.1%	USD/shares	10-Q	2018-04-27
Quarterly	2017-09-30	-0.07	+22.2%	USD/shares	10-Q	2017-10-31
Quarterly	2018-03-31	-0.26	-271.4%	USD/shares	10-Q	2019-04-29
Quarterly	2018-09-30	-0.07	+73.1%	USD/shares	10-Q/A	2019-11-04
Quarterly	2019-03-31	-0.32	-357.1%	USD/shares	10-Q	2020-05-01
Quarterly	2019-06-30	-0.21	+34.4%	USD/shares	10-Q	2020-08-05
Quarterly	2019-09-30	0.3	+242.9%	USD/shares	10-Q	2020-11-06
Quarterly	2020-03-31	0.44	+46.7%	USD/shares	10-Q	2021-04-30
Quarterly	2020-06-30	-0.16	-136.4%	USD/shares	10-Q	2021-07-30
Quarterly	2020-09-30	4.01	+2606.2%	USD/shares	10-Q	2021-10-29
Quarterly	2021-03-31	0.09	-97.8%	USD/shares	10-Q	2022-04-29
Quarterly	2021-06-30	0.07	-22.2%	USD/shares	10-Q	2022-08-04
Quarterly	2021-09-30	-0.2	-385.7%	USD/shares	10-Q	2022-10-28
Quarterly	2022-03-31	0.63	+415.0%	USD/shares	10-Q	2023-04-28
Quarterly	2022-06-30	0.15	-76.2%	USD/shares	10-Q	2023-08-02
Quarterly	2022-09-30	-0.04	-126.7%	USD/shares	10-Q	2023-11-02
Quarterly	2023-03-31	0.27	+775.0%	USD/shares	10-Q	2024-04-26
Quarterly	2023-06-30	0.29	+7.4%	USD/shares	10-Q	2024-08-05
Quarterly	2023-09-30	0.21	-27.6%	USD/shares	10-Q	2024-10-31
Quarterly	2024-03-31	0.46	+119.0%	USD/shares	10-Q	2025-05-02
Quarterly	2024-06-30	0.55	+19.6%	USD/shares	10-Q	2025-08-05
Quarterly	2024-09-30	0.55	+0.0%	USD/shares	10-Q	2025-10-28
Quarterly	2025-03-31	0.95	+72.7%	USD/shares	10-Q	2025-05-02
Quarterly	2025-06-30	1.23	+29.5%	USD/shares	10-Q	2025-08-05
Quarterly	2025-09-30	-0.16	-113.0%	USD/shares	10-Q	2025-10-28
Annual	2016-12-31	-3.81	—	USD/shares	10-K	2019-02-28
Annual	2017-12-31	-0.67	+82.4%	USD/shares	10-K	2020-02-27
Annual	2018-12-31	-0.44	+34.3%	USD/shares	10-K	2021-02-26
Annual	2019-12-31	-0.13	+70.5%	USD/shares	10-K	2022-02-25
Annual	2020-12-31	4.5	+3561.5%	USD/shares	10-K	2023-02-27
Annual	2021-12-31	-0.35	-107.8%	USD/shares	10-K	2024-02-26
Annual	2022-12-31	0.75	+314.3%	USD/shares	10-K	2025-02-24
Annual	2023-12-31	0.87	+16.0%	USD/shares	10-K	2026-02-26
Annual	2024-12-31	2.21	+154.0%	USD/shares	10-K	2026-02-26
Annual	2025-12-31	1.8	-18.6%	USD/shares	10-K	2026-02-26

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	45204000.0	—	USD	10-Q	2017-05-04
Quarterly	2016-06-30	70710000.0	+56.4%	USD	10-Q	2017-08-02
Quarterly	2016-09-30	96806000.0	+36.9%	USD	10-Q	2017-10-31
Quarterly	2017-03-31	69090000.0	-28.6%	USD	10-Q	2018-04-27
Quarterly	2017-06-30	116847000.0	+69.1%	USD	10-Q	2018-08-03
Quarterly	2017-09-30	159329000.0	+36.4%	USD	10-Q	2018-10-26
Quarterly	2018-03-31	30164000.0	-81.1%	USD	10-Q	2019-04-29
Quarterly	2018-06-30	52682000.0	+74.7%	USD	10-Q	2019-08-02
Quarterly	2018-09-30	102541000.0	+94.6%	USD	10-Q/A	2019-11-04
Quarterly	2019-03-31	28756000.0	-72.0%	USD	10-Q	2020-05-01
Quarterly	2019-06-30	61387000.0	+113.5%	USD	10-Q	2020-08-05
Quarterly	2019-09-30	94241000.0	+53.5%	USD	10-Q	2020-11-06
Quarterly	2020-03-31	40554000.0	-57.0%	USD	10-Q	2021-04-30
Quarterly	2020-06-30	66716000.0	+64.5%	USD	10-Q	2021-07-30
Quarterly	2020-09-30	83286000.0	+24.8%	USD	10-Q	2021-10-29
Quarterly	2021-03-31	25507000.0	-69.4%	USD	10-Q	2022-04-29
Quarterly	2021-06-30	48106000.0	+88.6%	USD	10-Q	2022-08-04
Quarterly	2021-09-30	66840000.0	+38.9%	USD	10-Q	2022-10-28
Quarterly	2022-03-31	28817000.0	-56.9%	USD	10-Q	2023-04-28
Quarterly	2022-06-30	55971000.0	+94.2%	USD	10-Q	2023-08-02
Quarterly	2022-09-30	85271000.0	+52.3%	USD	10-Q	2023-11-02
Quarterly	2023-03-31	24456000.0	-71.3%	USD	10-Q	2024-04-26
Quarterly	2023-06-30	46039000.0	+88.3%	USD	10-Q	2024-08-05
Quarterly	2023-09-30	67774000.0	+47.2%	USD	10-Q	2024-10-31
Quarterly	2024-03-31	26104000.0	-61.5%	USD	10-Q	2025-05-02
Quarterly	2024-06-30	47431000.0	+81.7%	USD	10-Q	2025-08-05
Quarterly	2024-09-30	65894000.0	+38.9%	USD	10-Q	2025-10-28
Quarterly	2025-03-31	16768000.0	-74.6%	USD	10-Q	2025-05-02
Quarterly	2025-06-30	33869000.0	+102.0%	USD	10-Q	2025-08-05
Quarterly	2025-09-30	62316000.0	+84.0%	USD	10-Q	2025-10-28
Annual	2016-12-31	148380000.0	—	USD	10-K	2019-02-28
Annual	2017-12-31	199219000.0	+34.3%	USD	10-K	2020-02-27
Annual	2018-12-31	144620000.0	-27.4%	USD	10-K	2021-02-26
Annual	2019-12-31	145026000.0	+0.3%	USD	10-K	2022-02-25
Annual	2020-12-31	114312000.0	-21.2%	USD	10-K	2023-02-27
Annual	2021-12-31	95578000.0	-16.4%	USD	10-K	2024-02-26
Annual	2022-12-31	120959000.0	+26.6%	USD	10-K	2025-02-24
Annual	2023-12-31	96691000.0	-20.1%	USD	10-K	2026-02-26
Annual	2024-12-31	85424000.0	-11.7%	USD	10-K	2026-02-26
Annual	2025-12-31	103038000.0	+20.6%	USD	10-K	2026-02-26

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	161548000.0	—	shares	10-Q	2017-05-04
Quarterly	2016-06-30	162587000.0	+0.6%	shares	10-Q	2017-08-02
Quarterly	2016-09-30	167714000.0	+3.2%	shares	10-Q	2017-10-31
Quarterly	2017-03-31	172710000.0	+3.0%	shares	10-Q	2018-04-27
Quarterly	2017-06-30	174374000.0	+1.0%	shares	10-Q	2018-08-03
Quarterly	2017-09-30	175103000.0	+0.4%	shares	10-Q	2018-10-26
Quarterly	2018-03-31	176150000.0	+0.6%	shares	10-Q	2019-04-29
Quarterly	2018-06-30	176873000.0	+0.4%	shares	10-Q	2018-08-03
Quarterly	2018-09-30	177481000.0	+0.3%	shares	10-Q/A	2019-11-04
Quarterly	2019-03-31	178271000.0	+0.4%	shares	10-Q	2020-05-01
Quarterly	2019-06-30	179048000.0	+0.4%	shares	10-Q	2020-08-05
Quarterly	2019-09-30	185924000.0	+3.8%	shares	10-Q	2020-11-06
Quarterly	2020-03-31	187163000.0	+0.7%	shares	10-Q	2021-04-30
Quarterly	2020-06-30	180729000.0	-3.4%	shares	10-Q	2021-07-30
Quarterly	2020-09-30	197674000.0	+9.4%	shares	10-Q	2021-10-29
Quarterly	2021-03-31	184365000.0	-6.7%	shares	10-Q	2022-04-29
Quarterly	2021-06-30	185427000.0	+0.6%	shares	10-Q	2022-08-04
Quarterly	2021-09-30	183214000.0	-1.2%	shares	10-Q	2022-10-28
Quarterly	2022-03-31	194886000.0	+6.4%	shares	10-Q	2023-04-28
Quarterly	2022-06-30	187448000.0	-3.8%	shares	10-Q	2023-08-02
Quarterly	2022-09-30	185597000.0	-1.0%	shares	10-Q	2023-11-02
Quarterly	2023-03-31	194363000.0	+4.7%	shares	10-Q	2024-04-26
Quarterly	2023-06-30	194998000.0	+0.3%	shares	10-Q	2024-08-05
Quarterly	2023-09-30	191173000.0	-2.0%	shares	10-Q	2024-10-31
Quarterly	2024-03-31	199262000.0	+4.2%	shares	10-Q	2025-05-02
Quarterly	2024-06-30	200505000.0	+0.6%	shares	10-Q	2025-08-05
Quarterly	2024-09-30	197147000.0	-1.7%	shares	10-Q	2025-10-28
Quarterly	2025-03-31	196474000.0	-0.3%	shares	10-Q	2025-05-02
Quarterly	2025-06-30	197091000.0	+0.3%	shares	10-Q	2025-08-05
Quarterly	2025-09-30	192032000.0	-2.6%	shares	10-Q	2025-10-28
Annual	2016-12-31	166219000.0	—	shares	10-K	2019-02-28
Annual	2017-12-31	174427000.0	+4.9%	shares	10-K	2020-02-27
Annual	2018-12-31	177268000.0	+1.6%	shares	10-K	2021-02-26
Annual	2019-12-31	179039000.0	+1.0%	shares	10-K	2022-02-25
Annual	2020-12-31	191678000.0	+7.1%	shares	10-K	2023-02-27
Annual	2021-12-31	182852000.0	-4.6%	shares	10-K	2024-02-26
Annual	2022-12-31	188963000.0	+3.3%	shares	10-K	2025-02-24
Annual	2023-12-31	191595000.0	+1.4%	shares	10-K	2026-02-26
Annual	2024-12-31	196708000.0	+2.7%	shares	10-K	2026-02-26
Annual	2025-12-31	197394000.0	+0.3%	shares	10-K	2026-02-26

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

N/A

Total Liabilities (latest annual)

1,507,023,000

Current Liabilities (latest annual)

759,031,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-0.0363	—	ratio	10-Q	2017-05-04
Quarterly	2016-06-30	-0.2185	-502.6%	ratio	10-Q	2017-08-02
Quarterly	2016-09-30	-0.0141	+93.5%	ratio	10-Q	2017-10-31
Quarterly	2017-03-31	-0.0059	+58.4%	ratio	10-Q	2018-04-27
Quarterly	2017-06-30	-0.0132	-124.0%	ratio	10-Q	2018-08-03
Quarterly	2017-09-30	-0.0045	+66.2%	ratio	10-Q	2018-10-26
Quarterly	2018-03-31	-0.0157	-253.0%	ratio	10-Q	2019-04-29
Quarterly	2018-06-30	-0.0058	+63.0%	ratio	10-Q	2019-08-02
Quarterly	2018-09-30	-0.0043	+25.6%	ratio	10-Q/A	2019-11-04
Quarterly	2019-03-31	-0.0192	-344.2%	ratio	10-Q	2020-05-01
Quarterly	2019-06-30	-0.0126	+34.3%	ratio	10-Q	2020-08-05
Quarterly	2019-09-30	0.0179	+241.6%	ratio	10-Q	2020-11-06
Quarterly	2020-03-31	0.0251	+40.3%	ratio	10-Q	2021-04-30
Quarterly	2020-06-30	-0.0090	-135.9%	ratio	10-Q	2021-07-30
Quarterly	2020-09-30	0.1936	+2247.1%	ratio	10-Q	2021-10-29
Quarterly	2021-03-31	0.0042	-97.8%	ratio	10-Q	2022-04-29
Quarterly	2021-06-30	0.0031	-26.8%	ratio	10-Q	2022-08-04
Quarterly	2021-09-30	-0.0086	-380.4%	ratio	10-Q	2022-10-28
Quarterly	2022-03-31	0.0275	+421.6%	ratio	10-Q	2023-04-28
Quarterly	2022-06-30	0.0061	-77.7%	ratio	10-Q	2023-08-02
Quarterly	2022-09-30	-0.0015	-123.7%	ratio	10-Q	2023-11-02
Quarterly	2023-03-31	0.0109	+849.6%	ratio	10-Q	2024-04-26
Quarterly	2023-06-30	0.0117	+7.4%	ratio	10-Q	2024-08-05
Quarterly	2023-09-30	0.0082	-29.6%	ratio	10-Q	2024-10-31
Quarterly	2024-03-31	0.0175	+111.9%	ratio	10-Q	2025-05-02
Quarterly	2024-06-30	0.0203	+16.0%	ratio	10-Q	2025-08-05
Quarterly	2024-09-30	0.0196	-3.3%	ratio	10-Q	2025-10-28
Quarterly	2025-03-31	0.0321	+63.6%	ratio	10-Q	2025-05-02
Quarterly	2025-06-30	0.0399	+24.5%	ratio	10-Q	2025-08-05
Quarterly	2025-09-30	-0.0051	-112.7%	ratio	10-Q	2025-10-28
Annual	2016-12-31	-0.2278	—	ratio	10-K	2019-02-28
Annual	2017-12-31	-0.0417	+81.7%	ratio	10-K	2020-02-27
Annual	2018-12-31	-0.0260	+37.6%	ratio	10-K	2021-02-26
Annual	2019-12-31	-0.0076	+70.6%	ratio	10-K	2022-02-25
Annual	2020-12-31	0.2083	+2826.6%	ratio	10-K	2023-02-27
Annual	2021-12-31	-0.0150	-107.2%	ratio	10-K	2024-02-26
Annual	2022-12-31	0.0308	+304.7%	ratio	10-K	2025-02-24
Annual	2023-12-31	0.0339	+10.1%	ratio	10-K	2026-02-26
Annual	2024-12-31	0.0754	+122.8%	ratio	10-K	2026-02-26
Annual	2025-12-31	0.0573	-24.0%	ratio	10-K	2026-02-26

8-K Material Event Details

58 filings · 106 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

896 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-03-18	Davis George Eric	EVP, Chief Legal Officer	Other disposed transaction F	Common Stock	1,273	$56.05	$71,352	78,560
2026-03-17	Hubbard Cristin	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	1,245	$56.05	$69,782	44,790
2026-03-17	Guyer Charles Greg	EVP, Chief Technical Officer	Other disposed transaction F	Common Stock	1,693	$56.05	$94,893	84,140
2026-03-16	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A · derivative	Stock Option (Right to Buy Common Stock)	35,680	$0.00	$0	35,680
2026-03-16	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A	Common Stock	14,990	$0.00	$0	85,833
2026-03-16	Hubbard Cristin	EVP, Chief Commercial Officer	Equity grant / award A · derivative	Stock Option (Right to Buy Common Stock)	36,680	$0.00	$0	36,680
2026-03-16	Hubbard Cristin	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	15,410	$0.00	$0	46,035
2026-03-13	Guyer Charles Greg	EVP, Chief Technical Officer	Other disposed transaction F	Common Stock	9,109	$58.51	$532,968	70,843
2026-03-11	Guyer Charles Greg	EVP, Chief Technical Officer	Open-market sell S	Common Stock	16,486	$60.46	$996,744	79,953
2026-02-26	Friberg Gregory R	EVP, Chief R&D Officer	Open-market sell S	Common Stock	6,326	$60.38	$381,937	37,578
2026-02-25	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A	Common Stock	2,371	$0.00	$0	96,439
2026-02-25	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A	Common Stock	6,675	$0.00	$0	94,068
2026-02-25	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A	Common Stock	6,176	$0.00	$0	87,393
2026-01-20	Ramchandani Rashmi Virendra	VP, Chief Accounting Officer	Equity grant / award A · derivative	Stock Option (Right to Buy Common Stock)	18,220	$0.00	$0	18,220
2026-01-20	Ramchandani Rashmi Virendra	VP, Chief Accounting Officer	Equity grant / award A	Common Stock	7,070	$0.00	$0	25,610
2026-01-20	Ramchandani Rashmi Virendra	VP, Chief Accounting Officer	Equity grant / award A	Common Stock	18,540	$0.00	$0	18,540
2025-12-01	Hardy Alexander	Chief Executive Officer	Other disposed transaction F	Common Stock	16,570	$55.03	$911,847	159,388
2025-09-30	Friberg Gregory R	EVP, Chief R&D Officer	Other disposed transaction F	Common Stock	3,304	$54.16	$178,945	43,506
2025-08-01	CLARK IAN T	Dir	Equity grant / award A	Common Stock	7,000	$0.00	$0	7,000
2025-05-20	Burkhart Erin	GVP, Chief Accounting Officer	Open-market sell S	Common Stock	1,786	$59.31	$105,928	14,173
2025-05-20	Hubbard Cristin	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	2,155	$59.93	$129,149	30,545
2025-05-19	Burkhart Erin	GVP, Chief Accounting Officer	Other disposed transaction F	Common Stock	996	$59.27	$59,033	15,959
2025-05-02	Hubbard Cristin	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	273	$64.92	$17,723	32,700
2025-04-30	Hubbard Cristin	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	273	$54.14	$14,779	32,973
2025-04-30	Hardy Alexander	Chief Executive Officer	Equity grant / award A	Common Stock	375	$54.14	$20,301	175,958
2025-03-19	Burkhart Erin	GVP, Chief Accounting Officer	Open-market sell S	Common Stock	1,295	$71.52	$92,618	16,955
2025-03-17	Burkhart Erin	GVP, Chief Accounting Officer	Equity grant / award A · derivative	Stock Option (Right to Buy Common Stock)	9,230	$0.00	$0	9,230
2025-03-17	Burkhart Erin	GVP, Chief Accounting Officer	Equity grant / award A	Common Stock	5,970	$0.00	$0	18,252
2025-03-17	Hubbard Cristin	EVP, Chief Commercial Officer	Equity grant / award A · derivative	Stock Option (Right to Buy Common Stock)	30,880	$0.00	$0	30,880
2025-03-17	Hubbard Cristin	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	13,310	$0.00	$0	32,700
2025-03-14	Burkhart Erin	GVP, Chief Accounting Officer	Other disposed transaction F	Common Stock	823	$69.44	$57,149	12,282
2025-03-06	Guyer Charles Greg	EVP, Chief Technical Officer	Open-market sell S	Common Stock	7,034	$71.28	$501,355	87,655
2025-02-28	Guyer Charles Greg	EVP, Chief Technical Officer	Other disposed transaction F	Common Stock	4,287	$71.16	$305,063	94,689
2025-02-25	Mueller Brian	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	9,367	$0.00	$0	101,638
2025-02-25	Mueller Brian	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	9,660	$0.00	$0	92,271
2025-02-25	Mueller Brian	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	11,040	$0.00	$0	82,611
2025-02-24	Walbert Timothy P	Dir	Equity grant / award A	Common Stock	3,130	$0.00	$0	3,130
2024-11-29	Hardy Alexander	Chief Executive Officer	Other disposed transaction F	Common Stock	14,295	$66.03	$943,899	134,156
2024-11-12	Guyer Charles Greg	EVP, Chief Technical Officer	Open-market sell S	Common Stock	5,278	$66.37	$350,324	68,909
2024-10-31	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A	Common Stock	55	$56.01	$3,080	74,187
2024-10-31	Hardy Alexander	Chief Executive Officer	Equity grant / award A	Common Stock	300	$56.01	$16,802	148,451
2024-09-30	Friberg Gregory R	EVP, Chief R&D Officer	Equity grant / award A · derivative	Stock Option (Right to Buy Common Stock)	49,850	$0.00	$0	49,850
2024-09-30	Friberg Gregory R	EVP, Chief R&D Officer	Equity grant / award A	Common Stock	7,870	$0.00	$0	29,060
2024-09-30	Friberg Gregory R	EVP, Chief R&D Officer	Equity grant / award A	Common Stock	21,190	$0.00	$0	21,190
2024-09-13	FUCHS HENRY J	President, Worldwide R&D	Other disposed transaction F	Common Stock	12,098	$84.90	$1,027,120	185,074
2024-08-13	Burkhart Erin	GVP, Chief Accounting Officer	Open-market sell S	Common Stock	714	$90.00	$64,260	14,449
2024-06-28	Mueller Brian	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	588	$82.33	$48,410	71,571
2024-06-03	HERON ELAINE J	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	5,047	$0.00	$0	0
2024-06-03	HERON ELAINE J	Dir	Other disposed transaction F	Common Stock	4,168	$76.41	$318,477	97,720
2024-06-03	HERON ELAINE J	Dir	Exercise / conversion M	Common Stock	5,047	$63.10	$318,466	101,888
2024-05-30	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	5,000	$0.00	$0	0
2024-05-30	Mueller Brian	EVP, Chief Financial Officer	Open-market sell S	Common Stock	5,000	$75.19	$375,950	72,159
2024-05-30	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M	Common Stock	5,000	$63.10	$315,500	77,159
2024-05-28	Davis George Eric	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	40,850	$0.00	$0	0
2024-05-28	Davis George Eric	EVP, Chief Legal Officer	Open-market sell S	Common Stock	2,779	$75.29	$209,225	56,157
2024-05-28	Davis George Eric	EVP, Chief Legal Officer	Open-market sell S	Common Stock	38,071	$74.45	$2,834,576	58,936
2024-05-28	Davis George Eric	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	40,850	$63.10	$2,577,635	97,007
2024-05-21	PYOTT DAVID E I	Dir	Equity grant / award A	Common Stock	4,720	$0.00	$0	49,750
2024-05-20	Hubbard Cristin	EVP, Chief Commercial Officer	Equity grant / award A · derivative	Stock Option (Right to Buy Common Stock)	33,520	$0.00	$0	33,520
2024-05-20	Hubbard Cristin	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	4,700	$0.00	$0	19,390
2024-05-20	Hubbard Cristin	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	14,690	$0.00	$0	14,690
2024-05-17	Burkhart Erin	GVP, Chief Accounting Officer	Other disposed transaction F	Common Stock	993	$76.97	$76,431	15,163
2024-05-10	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	20,000	$0.00	$0	51,000
2024-05-10	BIENAIME JEAN JACQUES	Dir	Open-market sell S	Common Stock	20,000	$81.14	$1,622,800	474,994
2024-05-10	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M	Common Stock	20,000	$63.10	$1,262,000	494,994
2024-05-09	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	20,000	$0.00	$0	71,000
2024-05-09	BIENAIME JEAN JACQUES	Dir	Open-market sell S	Common Stock	20,000	$81.62	$1,632,400	474,994
2024-05-09	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M	Common Stock	20,000	$63.10	$1,262,000	494,994
2024-05-03	Guyer Charles Greg	EVP, Chief Technical Officer	Other disposed transaction F	Common Stock	4,440	$82.44	$366,034	74,132
2024-05-02	Davis George Eric	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	1,850	$0.00	$0	40,850
2024-05-02	Davis George Eric	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,850	$85.01	$157,268	56,157
2024-05-02	Davis George Eric	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	1,850	$63.10	$116,735	58,007
2024-04-30	Davis George Eric	EVP, Chief Legal Officer	Equity grant / award A	Common Stock	301	$68.65	$20,662	56,157
2024-04-30	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A	Common Stock	245	$68.65	$16,818	78,572
2024-04-30	Mueller Brian	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	300	$68.65	$20,594	72,159
2024-04-30	FUCHS HENRY J	President, Worldwide R&D	Equity grant / award A	Common Stock	300	$68.65	$20,594	197,172
2024-04-12	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	20,000	$0.00	$0	91,000
2024-04-12	BIENAIME JEAN JACQUES	Dir	Open-market sell S	Common Stock	20,000	$91.26	$1,825,200	474,994
2024-04-12	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M	Common Stock	20,000	$63.10	$1,262,000	494,994
2024-04-11	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	20,000	$0.00	$0	111,000
2024-04-11	BIENAIME JEAN JACQUES	Dir	Open-market sell S	Common Stock	20,000	$90.99	$1,819,800	474,994
2024-04-11	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M	Common Stock	20,000	$63.10	$1,262,000	494,994
2024-04-10	Burkhart Erin	GVP, Chief Accounting Officer	Open-market sell S	Common Stock	2,286	$90.00	$205,740	16,156
2024-03-28	Davis George Eric	EVP, Chief Legal Officer	Open-market sell S	Common Stock	24,602	$88.34	$2,173,341	55,856
2024-03-18	Burkhart Erin	GVP, Chief Accounting Officer	Other disposed transaction F	Common Stock	372	$83.87	$31,200	18,442
2024-03-18	Slamon Dennis	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	10,000	$0.00	$0	0
2024-03-18	Slamon Dennis	Dir	Other disposed transaction F	Common Stock	9,510	$83.81	$797,033	31,299
2024-03-18	Slamon Dennis	Dir	Exercise / conversion M	Common Stock	10,000	$79.70	$797,000	40,809
2024-03-15	Burkhart Erin	GVP, Chief Accounting Officer	Equity grant / award A · derivative	Stock Option (Right to Buy Common Stock)	7,050	$0.00	$0	7,050
2024-03-15	Burkhart Erin	GVP, Chief Accounting Officer	Equity grant / award A	Common Stock	4,720	$0.00	$0	18,814
2024-03-05	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	35,341	$85.18	$3,010,396	212,117
2024-02-27	Mueller Brian	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	6,103	$0.00	$0	81,248
2024-02-27	Mueller Brian	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	8,802	$0.00	$0	75,145
2024-02-27	Mueller Brian	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	20,220	$0.00	$0	66,343
2024-02-09	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	15,000	$0.00	$0	131,000
2024-02-09	BIENAIME JEAN JACQUES	Dir	Open-market sell S	Common Stock	15,000	$88.28	$1,324,200	419,602
2024-02-09	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M	Common Stock	15,000	$63.10	$946,500	434,602
2024-02-08	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	15,000	$0.00	$0	146,000
2024-02-08	BIENAIME JEAN JACQUES	Dir	Open-market sell S	Common Stock	15,000	$89.77	$1,346,550	419,602
2024-02-08	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M	Common Stock	15,000	$63.10	$946,500	434,602
2024-01-18	BIENAIME JEAN JACQUES	Dir	Equity grant / award L	Common Stock	40	$92.60	$3,704	419,602
2024-01-08	MEIER RICHARD A	Dir	Equity grant / award G	Common Stock	3,000	$0.00	$0	112,547
2023-12-27	Bodem Barbara W.	Dir	Equity grant / award A	Common Stock	2,180	$0.00	$0	2,180
2023-12-21	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	10,000	$0.00	$0	181,000
2023-12-21	BIENAIME JEAN JACQUES	Dir	Open-market sell S	Common Stock	10,000	$93.99	$939,900	425,112
2023-12-21	BIENAIME JEAN JACQUES	Dir	Exercise / conversion M	Common Stock	10,000	$63.10	$631,000	435,112
2023-12-13	Davis George Eric	EVP, Chief Legal Officer	Open-market sell S	Common Stock	13,764	$95.30	$1,311,709	55,710
2023-12-01	BIENAIME JEAN JACQUES	Dir	Equity grant / award A	Common Stock	2,370	$0.00	$0	425,112
2023-12-01	Hardy Alexander	Chief Executive Officer	Equity grant / award A · derivative	Stock Option (Right to Buy Common Stock)	150,529	$0.00	$0	150,529
2023-12-01	Hardy Alexander	Chief Executive Officer	Equity grant / award A	Common Stock	47,332	$0.00	$0	115,371
2023-12-01	Hardy Alexander	Chief Executive Officer	Equity grant / award A	Common Stock	68,039	$0.00	$0	68,039
2023-10-04	BIENAIME JEAN JACQUES	Dir	Equity grant / award L	Common Stock	10	$85.57	$856	422,742
2023-08-16	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	5,000	$90.00	$450,000	60,804
2023-08-10	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	12,000	$90.43	$1,085,111	176,187
2023-08-09	Guyer Charles Greg	EVP, Chief Technical Officer	Open-market sell S	Common Stock	5,360	$93.30	$500,109	40,041
2023-08-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	6,000	$88.29	$529,740	422,732
2023-08-08	Davis George Eric	EVP, Chief Legal Officer	Open-market sell S	Common Stock	11,000	$89.42	$983,662	69,474
2023-08-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$88.10	$352,400	428,732
2023-06-29	Mueller Brian	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	576	$88.93	$51,224	45,805
2023-06-29	Mueller Brian	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	4,602	$88.93	$409,256	46,381
2023-05-23	Slamon Dennis	Dir	Equity grant / award A	Common Stock	4,190	$0.00	$0	30,809
2023-05-16	Davis George Eric	EVP, Chief Legal Officer	Equity grant / award G	Common Stock	210	$0.00	$0	80,474
2023-05-16	Burkhart Erin	GVP, Chief Accounting Officer	Other disposed transaction F	Common Stock	796	$92.02	$73,248	14,094
2023-05-12	MEIER RICHARD A	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	8,500	$0.00	$0	0
2023-05-12	MEIER RICHARD A	Dir	Other disposed transaction F	Common Stock	6,137	$93.93	$576,448	111,357
2023-05-12	MEIER RICHARD A	Dir	Exercise / conversion M	Common Stock	8,500	$67.81	$576,385	117,494
2023-05-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	30,000	$0.00	$0	39,130
2023-05-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,561	$95.22	$529,518	426,213
2023-05-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	24,439	$94.55	$2,310,707	431,774
2023-05-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	30,000	$67.81	$2,034,300	456,213
2023-04-28	Davis George Eric	EVP, Chief Legal Officer	Equity grant / award A	Common Stock	317	$66.88	$21,201	80,684
2023-04-28	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	318	$66.88	$21,267	65,804
2023-04-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	10,000	$0.00	$0	129,130
2023-04-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$99.56	$995,600	425,896
2023-04-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$67.81	$678,100	435,896
2023-04-06	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	10,000	$0.00	$0	139,130
2023-04-06	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$96.13	$961,300	425,896
2023-04-06	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$67.81	$678,100	435,896
2023-04-03	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy Common Stock)	8,500	$0.00	$0	0
2023-04-03	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	8,500	$97.09	$825,265	28,950
2023-04-03	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	8,500	$67.81	$576,385	37,450
2023-03-15	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A · derivative	Stock Option (Right to buy Common Stock)	20,320	$0.00	$0	20,320
2023-03-15	Guyer Charles Greg	EVP, Chief Technical Officer	Other disposed transaction F	Common Stock	1,856	$87.74	$162,845	49,464
2023-03-15	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A	Common Stock	8,900	$0.00	$0	51,320
2023-03-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	8,000	$0.00	$0	149,130
2023-03-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	8,000	$90.45	$723,600	487,856
2023-03-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	8,000	$67.81	$542,480	495,856
2023-03-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	15,000	$0.00	$0	157,130
2023-03-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	15,000	$92.28	$1,384,200	487,856
2023-03-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	15,000	$67.81	$1,017,150	502,856
2023-02-28	Mueller Brian	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	1,250	$0.00	$0	52,636
2023-02-28	Mueller Brian	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	10,980	$0.00	$0	51,386
2023-02-28	Mueller Brian	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	12,660	$0.00	$0	40,406
2023-02-24	Davis George Eric	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,474	$0.00	$0	0
2023-02-24	Davis George Eric	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	1,474	$67.81	$99,952	56,725
2023-02-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	6,000	$109.15	$654,900	320,324
2023-02-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	6,000	$67.81	$406,860	326,324
2023-02-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	6,000	$0.00	$0	172,130
2023-02-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	15,000	$0.00	$0	178,130
2023-02-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	15,000	$110.11	$1,651,650	320,324
2023-02-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	15,000	$67.81	$1,017,150	335,324
2023-02-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	100	$0.00	$0	100
2023-02-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	200	$0.00	$0	247,333
2023-01-25	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	46,800	$0.00	$0	0
2023-01-25	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,200	$0.00	$0	0
2023-01-25	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	4,175	$116.15	$484,943	41,088
2023-01-25	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	44,825	$115.65	$5,184,191	45,263
2023-01-25	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	49,000	$67.81	$3,322,690	90,088
2023-01-17	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	193,130
2023-01-17	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$111.55	$1,115,500	320,424
2023-01-17	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$67.81	$678,100	330,424
2023-01-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	203,130
2023-01-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$112.25	$1,122,500	320,424
2023-01-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$67.81	$678,100	330,424
2022-12-13	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,500	$0.00	$0	7,500
2022-12-13	Mueller Brian	EVP, Chief Financial Officer	Open-market sell S	Common Stock	2,500	$107.50	$268,750	27,746
2022-12-13	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M	Common Stock	2,500	$63.10	$157,750	30,246
2022-12-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	69	$104.06	$7,180	321,424
2022-12-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	100	$104.00	$10,400	321,493
2022-12-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	260	$103.98	$27,035	321,593
2022-12-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	600	$103.97	$62,383	321,853
2022-12-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	471	$103.97	$48,970	322,453
2022-12-02	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,761	$0.00	$0	0
2022-12-02	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,139	$0.00	$0	0
2022-12-02	Mueller Brian	EVP, Chief Financial Officer	Open-market sell S	Common Stock	3,761	$104.50	$393,024	27,746
2022-12-02	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M	Common Stock	3,761	$67.81	$255,033	31,507
2022-12-02	Mueller Brian	EVP, Chief Financial Officer	Open-market sell S	Common Stock	2,139	$104.50	$223,526	27,746
2022-12-02	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M	Common Stock	2,139	$67.81	$145,046	29,885
2022-12-02	Mueller Brian	EVP, Chief Financial Officer	Open-market sell S	Common Stock	1,101	$104.50	$115,054	27,746
2022-11-23	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,500	$0.00	$0	3,761
2022-11-23	Mueller Brian	EVP, Chief Financial Officer	Open-market sell S	Common Stock	3,500	$99.50	$348,250	28,847
2022-11-23	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M	Common Stock	3,500	$67.81	$237,335	32,347
2022-11-23	Mueller Brian	EVP, Chief Financial Officer	Open-market sell S	Common Stock	945	$99.50	$94,028	28,847
2022-11-23	Mueller Brian	EVP, Chief Financial Officer	Open-market sell S	Common Stock	934	$95.09	$88,814	29,792
2022-11-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award L	Common Stock	100	$86.12	$8,612	322,924
2022-10-31	Alles Mark J	Dir	Open-market buy P	Common Stock	3,625	$86.75	$314,469	10,905
2022-10-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$89.89	$359,560	324,324
2022-08-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	3,000	$95.21	$285,630	328,324
2022-08-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$94.75	$379,000	331,324
2022-08-11	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	3,000	$95.62	$286,860	44,088
2022-08-09	Davis George Eric	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	47,526	$0.00	$0	0
2022-08-09	Davis George Eric	EVP, Chief Legal Officer	Open-market sell S	Common Stock	47,526	$95.93	$4,559,169	55,251
2022-08-09	Davis George Eric	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	47,526	$67.81	$3,222,738	102,777
2022-08-09	Davis George Eric	EVP, Chief Legal Officer	Open-market sell S	Common Stock	3,690	$96.34	$355,495	55,251
2022-08-08	Guyer Charles Greg	EVP, Chief Technical Officer	Open-market sell S	Common Stock	6,205	$96.56	$599,155	42,168
2022-08-05	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,500	$0.00	$0	7,261
2022-08-05	Mueller Brian	EVP, Chief Financial Officer	Open-market sell S	Common Stock	3,500	$94.50	$330,750	30,726
2022-08-05	Mueller Brian	EVP, Chief Financial Officer	Exercise / conversion M	Common Stock	3,500	$67.81	$237,335	34,226
2022-07-08	Mueller Brian	EVP, Chief Financial Officer	Open-market sell S	Common Stock	7,337	$89.50	$656,662	30,726
2022-06-29	Mueller Brian	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	576	$83.92	$48,338	38,063
2022-06-03	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	7,021	$77.49	$544,057	47,088
2022-05-26	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,308	$78.94	$103,254	54,109
2022-05-24	Slamon Dennis	Dir	Equity grant / award A	Common Stock	4,980	$0.00	$0	26,619
2022-05-16	Burkhart Erin	GVP, Chief Accounting Officer	Equity grant / award A · derivative	Stock Option (Right to buy Common Stock)	17,490	$0.00	$0	17,490
2022-05-16	Burkhart Erin	GVP, Chief Accounting Officer	Equity grant / award A	Common Stock	11,130	$0.00	$0	11,130
2022-05-02	MEIER RICHARD A	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	8,500	$0.00	$0	0
2022-05-02	MEIER RICHARD A	Dir	Open-market sell S	Common Stock	18	$82.11	$1,478	104,014
2022-05-02	MEIER RICHARD A	Dir	Open-market sell S	Common Stock	3,860	$82.09	$316,867	104,032
2022-05-02	MEIER RICHARD A	Dir	Exercise / conversion M	Common Stock	8,500	$37.46	$318,410	107,892
2022-04-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	30,000
2022-04-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$81.95	$409,750	334,983
2022-04-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$37.46	$187,300	339,983
2022-04-29	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	340	$62.41	$21,218	55,417
2022-04-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	20,000	$0.00	$0	35,000
2022-04-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	20,000	$83.79	$1,675,800	334,983
2022-04-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	20,000	$37.46	$749,200	354,983
2022-04-25	Davis George Eric	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,669	$0.00	$0	0
2022-04-25	Davis George Eric	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,669	$37.46	$99,981	65,998
2022-04-18	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	20,000	$0.00	$0	55,000
2022-04-18	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	20,000	$81.91	$1,638,200	334,983
2022-04-18	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	20,000	$37.46	$749,200	354,983
2022-04-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	75,000
2022-04-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$83.66	$836,600	334,983
2022-04-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$37.46	$374,600	344,983
2022-04-13	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,180	$82.47	$97,315	55,077
2022-03-30	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,381	$79.56	$109,872	56,257
2022-03-29	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,618	$79.43	$128,518	57,638
2022-03-23	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	6,129	$81.78	$501,230	59,256
2022-03-22	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,073	$81.00	$167,913	65,385
2022-03-21	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	6,129	$81.29	$498,226	63,329
2022-03-16	FUCHS HENRY J	President, Worldwide R&D	Other disposed transaction F	Common Stock	2,259	$80.72	$182,346	143,753
2022-03-15	FUCHS HENRY J	President, Worldwide R&D	Equity grant / award A · derivative	Stock Option (Right to buy Common Stock)	35,830	$0.00	$0	35,830
2022-03-15	FUCHS HENRY J	President, Worldwide R&D	Other disposed transaction F	Common Stock	12,101	$78.27	$947,145	146,012
2022-03-15	FUCHS HENRY J	President, Worldwide R&D	Equity grant / award A	Common Stock	38,790	$0.00	$0	158,113
2022-03-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	15,000	$0.00	$0	85,000
2022-03-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	15,000	$77.81	$1,167,150	338,569
2022-03-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	15,000	$37.46	$561,900	353,569
2022-03-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	15,000	$0.00	$0	100,000
2022-03-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	15,000	$77.57	$1,163,550	338,569
2022-03-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	15,000	$37.46	$561,900	353,569
2022-03-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award A	Common Stock	34,780	$0.00	$0	338,569
2022-02-28	Slamon Dennis	Dir	Open-market sell S	Common Stock	122	$78.36	$9,560	21,739
2022-02-28	Slamon Dennis	Dir	Open-market sell S	Common Stock	100	$78.37	$7,837	21,639
2022-02-28	Slamon Dennis	Dir	Open-market sell S	Common Stock	214	$78.35	$16,767	21,961
2022-02-28	Slamon Dennis	Dir	Open-market sell S	Common Stock	45	$78.34	$3,525	22,175
2022-02-28	Slamon Dennis	Dir	Open-market sell S	Common Stock	5,815	$78.33	$455,489	22,220
2022-02-25	HERON ELAINE J	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	8,500	$0.00	$0	0
2022-02-25	HERON ELAINE J	Dir	Exercise / conversion M	Common Stock	8,500	$37.46	$318,410	80,588
2022-02-03	Mueller Brian	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	1,072	$87.77	$94,089	29,709
2022-01-14	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,250	$0.00	$0	4,250
2022-01-14	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	4,250	$87.61	$372,342	23,970
2022-01-14	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	4,250	$37.46	$159,205	28,220
2022-01-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	115,000
2022-01-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$87.86	$439,300	303,789
2022-01-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$37.46	$187,300	308,789
2022-01-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	120,000
2022-01-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$89.00	$445,000	303,789
2022-01-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$37.46	$187,300	308,789
2022-01-03	Alles Mark J	Dir	Equity grant / award A	Common Stock	2,300	$0.00	$0	2,300
2021-12-21	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award L	Common Stock	100	$89.22	$8,922	303,789
2021-12-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	6,000	$0.00	$0	125,000
2021-12-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	6,000	$84.68	$508,080	303,689
2021-12-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	6,000	$37.46	$224,760	309,689
2021-12-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	6,000	$0.00	$0	131,000
2021-12-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	6,000	$82.71	$496,260	303,689
2021-12-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	6,000	$37.46	$224,760	309,689
2021-12-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	700	$0.00	$0	303,689
2021-12-01	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	1,500	$87.22	$130,832	304,389
2021-10-26	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,739	$73.60	$201,590	55,853
2021-10-20	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	137,000
2021-10-20	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$37.46	$37,460	305,839
2021-09-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award L	Common Stock	50	$78.77	$3,938	305,889
2021-08-02	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	5,518	$76.69	$423,175	58,590
2021-06-29	Mueller Brian	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	576	$83.46	$48,073	30,781
2021-06-21	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	138,000
2021-06-21	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$37.46	$37,460	304,839
2021-05-25	Slamon Dennis	Dir	Equity grant / award A	Common Stock	5,120	$0.00	$0	28,035
2021-05-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	8,513	$0.00	$0	0
2021-05-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	8,513	$77.29	$657,970	303,839
2021-05-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	8,513	$26.49	$225,509	312,352
2021-05-06	MEIER RICHARD A	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	15,000	$0.00	$0	0
2021-05-06	MEIER RICHARD A	Dir	Open-market sell S	Common Stock	5,068	$78.38	$397,245	94,272
2021-05-06	MEIER RICHARD A	Dir	Exercise / conversion M	Common Stock	15,000	$26.49	$397,350	99,340
2021-04-30	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	342	$62.41	$21,343	58,592
2021-04-23	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	58,513
2021-04-23	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$79.34	$793,400	302,498
2021-04-23	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$26.49	$264,900	312,498
2021-04-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	68,513
2021-04-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$78.91	$789,100	302,498
2021-04-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$26.49	$264,900	312,498
2021-04-19	Davis George Eric	EVP, General Counsel	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,709	$0.00	$0	0
2021-04-19	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	2,709	$79.58	$215,582	68,440
2021-04-19	Davis George Eric	EVP, General Counsel	Exercise / conversion M	Common Stock	2,709	$26.49	$71,761	71,149
2021-04-15	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	7,500	$0.00	$0	0
2021-04-15	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	7,500	$76.90	$576,750	18,850
2021-04-15	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	7,500	$26.49	$198,675	26,350
2021-04-08	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,537	$78.81	$121,131	58,250
2021-04-01	Mueller Brian	EVP, Chief Financial Officer	Open-market sell S	Common Stock	5,692	$76.30	$434,300	31,016
2021-03-30	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,652	$74.79	$123,553	59,787
2021-03-24	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,181	$76.30	$90,110	61,439
2021-03-22	Mueller Brian	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	516	$78.52	$40,516	36,708
2021-03-18	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,308	$77.99	$102,011	64,133
2021-03-15	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A · derivative	Stock Option (Right to buy Common Stock)	25,650	$0.00	$0	25,650
2021-03-15	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A	Common Stock	10,420	$0.00	$0	45,460
2021-03-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	7,000	$0.00	$0	78,513
2021-03-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	7,000	$77.10	$539,700	295,652
2021-03-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	7,000	$26.49	$185,430	302,652
2021-03-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	7,000	$0.00	$0	85,513
2021-03-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	7,000	$77.68	$543,760	295,652
2021-03-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	7,000	$26.49	$185,430	302,652
2021-03-05	GREY MICHAEL G	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	0
2021-03-05	GREY MICHAEL G	Dir	Open-market sell S	Common Stock	5,000	$76.28	$381,400	42,840
2021-03-05	GREY MICHAEL G	Dir	Exercise / conversion M	Common Stock	5,000	$26.49	$132,450	47,840
2021-03-04	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award L	Common Stock	100	$77.94	$7,794	295,652
2021-02-19	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	7,000	$0.00	$0	92,513
2021-02-19	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	7,000	$83.58	$585,060	295,552
2021-02-19	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	7,000	$26.49	$185,430	302,552
2021-02-18	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	7,000	$0.00	$0	99,513
2021-02-18	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	7,000	$85.08	$595,560	295,552
2021-02-18	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	7,000	$26.49	$185,430	302,552
2021-02-17	Ho Maykin	Dir	Equity grant / award A	Common Stock	2,350	$0.00	$0	2,350
2021-02-16	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	7,500	$0.00	$0	7,500
2021-02-16	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	7,500	$87.41	$655,575	18,850
2021-02-16	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	7,500	$26.49	$198,675	26,350
2021-02-03	Mueller Brian	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	1,071	$82.82	$88,700	28,673
2021-01-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	8,334	$0.00	$0	114,513
2021-01-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	8,334	$82.67	$688,972	295,552
2021-01-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	8,334	$26.49	$220,768	303,886
2021-01-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	8,333	$0.00	$0	122,847
2021-01-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	8,333	$82.91	$690,889	295,552
2021-01-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	8,333	$26.49	$220,741	303,885
2021-01-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	8,333	$0.00	$0	131,180
2021-01-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	8,333	$85.49	$712,388	295,552
2021-01-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	8,333	$26.49	$220,741	303,885
2020-12-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	1,500	$88.18	$132,270	295,552
2020-12-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	1,500	$88.77	$133,155	297,052
2020-10-14	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,121	$79.91	$169,489	61,281
2020-10-07	HERON ELAINE J	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	15,000	$0.00	$0	0
2020-10-07	HERON ELAINE J	Dir	Exercise / conversion M	Common Stock	15,000	$26.49	$397,350	66,968
2020-08-31	PYOTT DAVID E I	Dir	Open-market buy P	Common Stock	900	$78.84	$70,955	30,740
2020-08-31	PYOTT DAVID E I	Dir	Open-market buy P	Common Stock	11,900	$78.22	$930,760	29,840
2020-08-03	GREY MICHAEL G	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,500	$0.00	$0	5,000
2020-08-03	GREY MICHAEL G	Dir	Open-market sell S	Common Stock	2,500	$120.35	$300,875	42,840
2020-08-03	GREY MICHAEL G	Dir	Exercise / conversion M	Common Stock	2,500	$26.49	$66,225	45,340
2020-07-20	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	49,423	$0.00	$0	0
2020-07-20	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	75,716	$0.00	$0	0
2020-07-20	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,250	$0.00	$0	0
2020-07-20	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	126,389	$130.00	$16,430,570	102,995
2020-07-20	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	49,423	$63.10	$3,118,591	229,384
2020-07-20	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	75,716	$67.81	$5,134,302	179,961
2020-07-20	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	1,250	$67.81	$84,762	104,245
2020-07-17	Acosta Andrea	GVP, Chief Accouning Officer	Other disposed transaction F	Common Stock	285	$128.21	$36,540	14,674
2020-07-13	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	8,977	$0.00	$0	49,423
2020-07-13	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	13,810	$0.00	$0	75,716
2020-07-13	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	224	$0.00	$0	1,250
2020-07-13	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	23,011	$130.00	$2,991,430	102,995
2020-07-13	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	8,977	$63.10	$566,449	126,006
2020-07-13	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	13,810	$67.81	$936,456	117,029
2020-07-13	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	224	$67.81	$15,189	103,219
2020-07-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	425	$0.00	$0	247,533
2020-06-26	Dere Willard H	Dir	Open-market sell S	Common Stock	4,430	$123.61	$547,592	13,290
2020-06-05	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	4,430	$107.46	$476,048	18,850
2020-05-27	Slamon Dennis	Dir	Equity grant / award A	Common Stock	4,300	$0.00	$0	22,915
2020-05-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	20,000	$0.00	$0	0
2020-05-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	20,000	$91.72	$1,834,400	298,552
2020-05-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	20,000	$21.51	$430,200	318,552
2020-05-04	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A · derivative	Stock Option (Right to buy Common Stock)	64,150	$0.00	$0	64,150
2020-05-04	Guyer Charles Greg	EVP, Chief Technical Officer	Equity grant / award A	Common Stock	35,040	$0.00	$0	35,040
2020-04-30	FUCHS HENRY J	President, Worldwide R&D	Equity grant / award A	Common Stock	339	$62.59	$21,217	102,995
2020-04-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	20,000	$0.00	$0	29,000
2020-04-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	20,000	$97.58	$1,951,600	298,213
2020-04-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	20,000	$21.51	$430,200	318,213
2020-04-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	20,000	$0.00	$0	49,000
2020-04-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	20,000	$97.73	$1,954,600	298,213
2020-04-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	20,000	$21.51	$430,200	318,213
2020-04-24	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	2,680	$97.32	$260,813	102,656
2020-04-24	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	3,678	$96.85	$356,211	105,336
2020-04-24	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	13,642	$95.34	$1,300,593	109,014
2020-04-20	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	17,213	$90.00	$1,549,170	122,656
2020-04-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	69,000
2020-04-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$79.06	$790,600	298,213
2020-04-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$21.51	$215,100	308,213
2020-04-08	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,407	$79.98	$192,512	63,064
2020-04-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	139,513
2020-04-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$26.49	$26,490	298,213
2020-04-01	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,537	$82.00	$126,034	65,471
2020-03-25	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,618	$78.47	$126,964	67,008
2020-03-24	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,041	$74.36	$151,769	68,626
2020-03-20	Mueller Brian	SVP, Acting CFO	Other disposed transaction F	Common Stock	414	$73.05	$30,243	24,781
2020-03-17	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,750	$0.00	$0	0
2020-03-17	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	3,750	$75.39	$282,712	18,980
2020-03-17	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	3,750	$21.51	$80,662	22,730
2020-03-16	Mueller Brian	SVP, Acting CFO	Equity grant / award A · derivative	Stock Option (Right to buy Common Stock)	9,600	$0.00	$0	9,600
2020-03-16	Mueller Brian	SVP, Acting CFO	Equity grant / award A	Common Stock	6,730	$0.00	$0	25,195
2020-03-16	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	4,610	$76.52	$352,757	18,980
2020-03-13	Mueller Brian	SVP, Acting CFO	Other disposed transaction F	Common Stock	1,303	$84.50	$110,104	18,465
2020-03-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	79,000
2020-03-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$89.52	$895,200	296,443
2020-03-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$21.51	$215,100	306,443
2020-03-03	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award L	Common Stock	30	$94.39	$2,832	296,443
2020-02-03	Mueller Brian	SVP, Acting CFO	Equity grant / award A	Common Stock	5,800	$0.00	$0	19,768
2020-02-03	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	89,000
2020-02-03	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$83.50	$835,000	328,530
2020-02-03	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$21.51	$215,100	338,530
2020-01-30	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	99,000
2020-01-30	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$21.51	$21,510	328,530
2020-01-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	8,000	$0.00	$0	100,000
2020-01-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	8,000	$87.95	$703,600	327,530
2020-01-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	8,000	$21.51	$172,080	335,530
2020-01-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	108,000
2020-01-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$84.92	$339,680	327,530
2020-01-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$21.51	$86,040	331,530
2020-01-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	112,000
2020-01-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	3,000	$84.46	$253,380	327,530
2020-01-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,000	$21.51	$64,530	330,530
2019-12-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	115,000
2019-12-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$86.16	$430,800	327,530
2019-12-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$21.51	$107,550	332,530
2019-12-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	120,000
2019-12-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	3,000	$86.43	$259,290	327,530
2019-12-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,000	$21.51	$64,530	330,530
2019-12-17	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,750	$0.00	$0	3,750
2019-12-17	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	3,750	$83.36	$312,600	23,590
2019-12-17	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	3,750	$21.51	$80,662	27,340
2019-12-03	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	630	$0.00	$0	180,261
2019-11-26	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	3,190	$79.66	$254,115	68,709
2019-11-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	123,000
2019-11-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	6,000	$0.00	$0	127,000
2019-11-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$77.60	$776,000	327,080
2019-11-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$21.51	$215,100	337,080
2019-11-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award L	Common Stock	10	$75.38	$754	327,080
2019-11-05	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	450	$0.00	$0	327,070
2019-10-31	Mueller Brian	SVP, Acting CFO	Equity grant / award A	Common Stock	9	$62.23	$560	13,968
2019-10-25	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	133,000
2019-10-25	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$69.55	$347,750	327,520
2019-10-25	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$21.51	$107,550	332,520
2019-09-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	138,000
2019-09-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$21.51	$21,510	327,520
2019-09-17	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,750	$0.00	$0	7,500
2019-09-17	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	3,750	$74.47	$279,262	23,590
2019-09-17	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	3,750	$21.51	$80,662	27,340
2019-08-07	HERON ELAINE J	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,553	$0.00	$0	5,047
2019-08-07	HERON ELAINE J	Dir	Exercise / conversion M	Common Stock	1,553	$63.10	$97,994	47,668
2019-07-09	ANDERSON ELIZABETH M	Dir	Equity grant / award A	Common Stock	4,490	$0.00	$0	4,490
2019-06-17	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,750	$0.00	$0	11,250
2019-06-17	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	3,750	$81.08	$304,050	23,590
2019-06-17	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	3,750	$21.51	$80,662	27,340
2019-06-11	MEIER RICHARD A	Dir	Equity grant / award G	Common Stock	6,000	$0.00	$0	80,040
2019-06-05	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	14,160	$0.00	$0	61,635
2019-06-04	MEIER RICHARD A	Dir	Equity grant / award A	Common Stock	4,430	$0.00	$0	86,040
2019-05-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	0
2019-05-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$82.52	$825,193	326,520
2019-05-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$14.39	$143,900	336,520
2019-05-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	10,000
2019-05-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$81.97	$327,888	326,520
2019-05-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$14.39	$57,560	330,520
2019-04-30	BAFFI ROBERT	President, Global Mfg/Tech Ops	Equity grant / award A	Common Stock	309	$68.78	$21,254	107,727
2019-04-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	18,000
2019-04-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	200	$84.41	$16,881	326,211
2019-04-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	800	$83.59	$66,870	326,411
2019-04-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	2,000	$82.44	$164,889	327,211
2019-04-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,000	$14.39	$43,170	329,211
2019-04-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	139,000
2019-04-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$21.51	$21,510	326,211
2019-04-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	21,000
2019-04-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$89.12	$356,480	325,211
2019-04-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$14.39	$57,560	329,211
2019-04-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	25,000
2019-04-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$14.39	$14,390	325,211
2019-04-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	29,000
2019-04-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	700	$93.67	$65,572	324,211
2019-04-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	100	$92.39	$9,238	324,911
2019-04-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	2,200	$91.27	$200,787	325,011
2019-04-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,000	$14.39	$43,170	327,211
2019-04-05	Mueller Brian	SVP, Corporate Controller	Open-market sell S	Common Stock	2,953	$94.00	$277,582	13,660
2019-04-01	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Open-market sell S	Common Stock	13,473	$89.00	$1,199,097	47,510
2019-03-27	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,150	$0.00	$0	0
2019-03-27	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	2,150	$89.76	$192,984	19,160
2019-03-27	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	2,150	$14.39	$30,938	21,310
2019-03-26	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	3,656	$89.18	$326,025	47,475
2019-03-22	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	3,598	$88.05	$316,804	51,131
2019-03-21	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,930	$90.47	$174,614	54,729
2019-03-21	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,589	$89.62	$232,020	56,659
2019-03-19	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	37,000
2019-03-19	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$14.39	$14,390	336,338
2019-03-15	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Equity grant / award A · derivative	Stock Option (Right to buy Common Stock)	23,450	$0.00	$0	23,450
2019-03-15	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	9,370	$0.00	$0	64,681
2019-03-15	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	7,227	$94.53	$683,168	55,311
2019-03-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	42,000
2019-03-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	3,000	$93.42	$280,253	328,701
2019-03-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,000	$14.39	$43,170	331,701
2019-03-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	45,000
2019-03-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$91.44	$365,770	328,701
2019-03-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$14.39	$57,560	332,701
2019-03-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	49,000
2019-03-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$88.96	$444,780	328,701
2019-03-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$14.39	$71,950	333,701
2019-03-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	54,000
2019-03-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$90.78	$363,120	328,701
2019-03-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$14.39	$57,560	332,701
2019-03-04	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	2,196	$95.00	$208,620	142,504
2019-03-01	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	912	$94.76	$86,421	62,538
2019-03-01	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	12,205	$0.00	$0	63,450
2019-02-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	58,000
2019-02-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$91.78	$367,120	288,290
2019-02-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$14.39	$57,560	292,290
2019-02-21	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	62,000
2019-02-21	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	3,000	$90.12	$270,360	288,290
2019-02-21	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,000	$14.39	$43,170	291,290
2019-02-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	65,000
2019-02-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$95.20	$380,800	288,290
2019-02-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$14.39	$57,560	292,290
2019-02-05	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	69,000
2019-02-05	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$98.63	$394,520	288,290
2019-02-05	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$14.39	$57,560	292,290
2019-01-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	73,000
2019-01-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	3,000	$96.82	$290,460	288,290
2019-01-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,000	$14.39	$43,170	291,290
2019-01-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	76,000
2019-01-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$93.79	$375,160	288,290
2019-01-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$14.39	$57,560	292,290
2019-01-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	80,000
2019-01-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	3,000	$90.55	$271,650	288,290
2019-01-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,000	$14.39	$43,170	291,290
2019-01-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	6,000	$0.00	$0	83,000
2019-01-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	3,401	$91.73	$311,990	288,290
2019-01-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	1,599	$91.55	$146,388	291,691
2019-01-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	1,000	$91.14	$91,144	293,290
2019-01-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	6,000	$14.39	$86,340	294,290
2019-01-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	89,000
2019-01-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	3,000	$87.58	$262,740	288,290
2019-01-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,000	$14.39	$43,170	291,290
2018-12-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	92,000
2018-12-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	3,000	$84.04	$252,120	288,290
2018-12-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,000	$14.39	$43,170	291,290
2018-12-27	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,150	$0.00	$0	2,150
2018-12-27	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	2,150	$82.53	$177,440	19,160
2018-12-27	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	2,150	$14.39	$30,938	21,310
2018-12-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	95,000
2018-12-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$80.50	$322,000	288,290
2018-12-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$14.39	$57,560	292,290
2018-12-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,000	$0.00	$0	0
2018-12-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	2,000	$92.64	$185,280	288,290
2018-12-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	2,000	$17.86	$35,720	290,290
2018-12-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,000	$0.00	$0	2,000
2018-12-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	2,000	$93.12	$186,240	288,290
2018-12-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	2,000	$17.86	$35,720	290,290
2018-11-20	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	540	$0.00	$0	181,501
2018-11-19	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	160	$0.00	$0	182,041
2018-11-14	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	9,000	$0.00	$0	30,700
2018-11-14	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	600	$94.35	$56,611	49,135
2018-11-14	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	799	$93.81	$74,957	49,735
2018-11-14	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,400	$92.21	$221,297	50,534
2018-11-14	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	5,201	$91.62	$476,494	52,934
2018-11-14	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	9,000	$63.10	$567,900	58,135
2018-11-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,500	$0.00	$0	4,000
2018-11-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	1,500	$97.88	$146,820	288,290
2018-11-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,500	$17.86	$26,790	289,790
2018-11-01	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	4,000	$0.00	$0	99,000
2018-11-01	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$92.55	$370,200	288,290
2018-11-01	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$14.39	$57,560	292,290
2018-10-31	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	175	$68.78	$12,037	51,245
2018-10-30	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	103,000
2018-10-30	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$14.39	$14,390	288,290
2018-10-24	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	104,000
2018-10-24	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$14.39	$14,390	287,290
2018-10-03	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,000	$98.98	$98,985	49,135
2018-09-27	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,150	$0.00	$0	4,300
2018-09-27	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	2,150	$97.93	$210,550	19,160
2018-09-27	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	2,150	$14.39	$30,938	21,310
2018-09-25	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	105,000
2018-09-25	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$14.39	$14,390	286,290
2018-09-14	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	616	$99.46	$61,265	72,734
2018-09-14	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	200	$99.45	$19,891	73,350
2018-09-14	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	1,400	$99.45	$139,230	73,550
2018-09-13	MEIER RICHARD A	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	12,000	$0.00	$0	0
2018-09-13	MEIER RICHARD A	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	12,000
2018-09-13	MEIER RICHARD A	Dir	Open-market sell S	Common Stock	200	$99.25	$19,850	81,610
2018-09-13	MEIER RICHARD A	Dir	Open-market sell S	Common Stock	2,800	$99.24	$277,872	81,810
2018-09-13	MEIER RICHARD A	Dir	Exercise / conversion M	Common Stock	3,000	$21.51	$64,530	84,610
2018-09-13	MEIER RICHARD A	Dir	Exercise / conversion M	Common Stock	12,000	$21.51	$258,120	81,610
2018-09-05	HERON ELAINE J	Dir	Open-market sell S	Common Stock	1,000	$96.94	$96,935	41,685
2018-09-04	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,500	$0.00	$0	7,000
2018-09-04	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	1,500	$98.16	$147,240	285,290
2018-09-04	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,500	$17.86	$26,790	286,790
2018-08-28	LEWIS ALAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	7,500	$0.00	$0	0
2018-08-28	LEWIS ALAN	Dir	Open-market sell S	Common Stock	200	$99.12	$19,824	21,160
2018-08-28	LEWIS ALAN	Dir	Open-market sell S	Common Stock	7,300	$99.11	$723,503	21,360
2018-08-28	LEWIS ALAN	Dir	Exercise / conversion M	Common Stock	7,500	$14.39	$107,925	28,660
2018-08-27	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	12,500	$100.00	$1,250,000	130,167
2018-08-27	MEIER RICHARD A	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	13,000	$0.00	$0	0
2018-08-27	MEIER RICHARD A	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,000	$0.00	$0	13,000
2018-08-27	MEIER RICHARD A	Dir	Open-market sell S	Common Stock	2,000	$100.12	$200,235	69,610
2018-08-27	MEIER RICHARD A	Dir	Exercise / conversion M	Common Stock	2,000	$14.39	$28,780	71,610
2018-08-27	MEIER RICHARD A	Dir	Exercise / conversion M	Common Stock	13,000	$14.39	$187,070	69,610
2018-08-24	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	12,500	$99.00	$1,237,500	142,667
2018-08-21	LEWIS ALAN	Dir	Open-market sell S	Common Stock	4,200	$100.09	$420,365	21,160
2018-08-07	BAFFI ROBERT	EVP, Technical Operations	Open-market sell S	Common Stock	5,173	$105.00	$543,165	71,882
2018-07-23	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,500	$0.00	$0	8,500
2018-07-23	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	1,500	$101.69	$152,535	285,290
2018-07-23	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,500	$17.86	$26,790	286,790
2018-06-27	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,150	$0.00	$0	6,450
2018-06-27	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	2,150	$93.52	$201,068	19,160
2018-06-27	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	2,150	$14.39	$30,938	21,310
2018-06-22	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Open-market sell S	Common Stock	472	$99.01	$46,733	51,070
2018-06-22	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Open-market sell S	Common Stock	9,528	$99.00	$943,272	51,542
2018-06-15	Mueller Brian	SVP, Corporate Controller	Open-market sell S	Common Stock	2,021	$94.50	$190,984	13,029
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	20,681	$0.00	$0	0
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,875	$0.00	$0	0
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,669	$0.00	$0	0
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,775	$0.00	$0	0
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,000	$0.00	$0	0
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	20,681	$90.00	$1,861,375	155,167
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	20,681	$37.46	$774,710	175,848
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	1,875	$90.00	$168,750	155,167
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	1,875	$26.49	$49,669	157,042
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	2,669	$90.00	$240,210	155,167
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	2,669	$37.46	$99,981	157,836
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	3,775	$90.00	$339,750	155,167
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	3,775	$26.49	$100,000	158,942
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	2,000	$90.00	$180,000	155,167
2018-06-14	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	2,000	$21.51	$43,020	157,167
2018-06-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	106,000
2018-06-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$14.39	$14,390	285,290
2018-06-11	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,436	$90.31	$129,685	50,135
2018-06-05	HOMBACH ROBERT J.	Dir	Equity grant / award A	Common Stock	4,300	$0.00	$0	7,480
2018-06-04	FUCHS HENRY J	President, Worldwide R&D	Other disposed transaction F	Common Stock	1,934	$92.07	$178,063	155,167
2018-06-04	Mueller Brian	SVP, Corporate Controller	Other disposed transaction F	Common Stock	346	$92.07	$31,856	15,050
2018-05-17	MEIER RICHARD A	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy) Common Stock	15,000	$0.00	$0	0
2018-05-17	MEIER RICHARD A	Dir	Exercise / conversion M	Common Stock	15,000	$38.59	$578,850	51,310
2018-05-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	18,750	$0.00	$0	18,750
2018-05-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	18,750	$89.13	$1,671,131	290,600
2018-05-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	18,750	$38.59	$723,562	309,350
2018-05-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	18,750	$0.00	$0	37,500
2018-05-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	18,750	$88.29	$1,655,434	290,600
2018-05-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	18,750	$38.59	$723,562	309,350
2018-05-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	18,750	$0.00	$0	56,250
2018-05-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	18,750	$89.22	$1,672,851	290,600
2018-05-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	18,750	$38.59	$723,562	309,350
2018-04-30	FUCHS HENRY J	President, Worldwide R&D	Equity grant / award A	Common Stock	309	$68.78	$21,254	157,101
2018-04-23	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Open-market sell S	Common Stock	11,059	$82.15	$908,497	62,543
2018-04-20	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	132,500
2018-04-20	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$83.65	$836,458	290,031
2018-04-20	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$38.59	$385,900	300,031
2018-04-17	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	3,750	$0.00	$0	0
2018-04-17	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	3,750	$85.00	$318,750	14,860
2018-04-17	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	3,750	$38.59	$144,712	18,610
2018-04-05	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	107,000
2018-04-05	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$14.39	$14,390	290,031
2018-04-02	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,119	$80.12	$169,774	52,914
2018-03-29	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,537	$79.69	$122,484	55,033
2018-03-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	109,000
2018-03-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$14.39	$14,390	288,031
2018-03-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	110,000
2018-03-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$14.39	$14,390	286,031
2018-03-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	111,000
2018-03-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$14.39	$14,390	285,031
2018-03-23	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	3,350	$81.35	$272,522	87,989
2018-03-22	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	3,598	$81.36	$292,733	73,587
2018-03-22	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	3,583	$81.36	$291,513	73,602
2018-03-21	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	4,368	$83.90	$366,475	60,153
2018-03-16	Mueller Brian	SVP, Corporate Controller	Other disposed transaction F	Common Stock	346	$84.10	$29,099	12,263
2018-03-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	15,000	$0.00	$0	142,500
2018-03-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	15,000	$83.26	$1,248,854	296,106
2018-03-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	15,000	$38.59	$578,850	311,106
2018-03-15	Mueller Brian	SVP, Corporate Controller	Equity grant / award A · derivative	Stock Option (Right to buy Common Stock)	9,120	$0.00	$0	9,120
2018-03-15	Mueller Brian	SVP, Corporate Controller	Equity grant / award A	Common Stock	5,710	$0.00	$0	17,973
2018-03-15	Mueller Brian	SVP, Corporate Controller	Other disposed transaction F	Common Stock	309	$83.57	$25,823	12,609
2018-03-09	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,972	$82.39	$244,863	55,332
2018-03-05	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	2,105	$79.04	$166,379	90,089
2018-03-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,000	$0.00	$0	113,000
2018-03-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Other disposed transaction F	Common Stock	8,542	$79.86	$682,164	264,674
2018-03-02	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	1,000	$14.39	$14,390	273,216
2018-02-26	Davis George Eric	EVP, General Counsel	Equity grant / award A	Common Stock	11,523	$0.00	$0	94,265
2018-02-26	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	12,615	$0.00	$0	70,215
2018-02-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	172,500
2018-02-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$84.63	$846,285	226,494
2018-02-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$38.59	$385,900	236,494
2018-02-01	Davis George Eric	EVP, General Counsel	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	30,000	$0.00	$0	0
2018-02-01	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	30,000	$90.66	$2,719,665	82,942
2018-02-01	Davis George Eric	EVP, General Counsel	Exercise / conversion M	Common Stock	30,000	$38.59	$1,157,700	112,942
2018-01-05	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	182,500
2018-01-05	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$90.32	$903,203	225,894
2018-01-05	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$38.59	$385,900	235,894
2018-01-02	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	3,750	$0.00	$0	3,750
2018-01-02	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	3,750	$88.84	$333,150	14,860
2018-01-02	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	3,750	$38.59	$144,712	18,610
2017-12-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	192,500
2017-12-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$89.61	$896,125	225,894
2017-12-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$38.59	$385,900	235,894
2017-12-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	10,000	$0.00	$0	202,500
2017-12-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	10,000	$89.89	$898,912	225,894
2017-12-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,000	$38.59	$385,900	235,894
2017-12-14	HERON ELAINE J	Dir	Open-market sell S	Common Stock	800	$88.89	$71,116	38,385
2017-12-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	600	$0.00	$0	182,201
2017-12-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	600	$0.00	$0	225,894
2017-11-30	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	1,200	$85.64	$102,767	82,942
2017-09-29	HOMBACH ROBERT J.	Dir	Equity grant / award A	Common Stock	3,180	$0.00	$0	3,180
2017-09-28	BAFFI ROBERT	EVP, Technical Operations	Open-market sell S	Common Stock	2,915	$92.06	$268,355	28,761
2017-09-28	BAFFI ROBERT	EVP, Technical Operations	Open-market sell S	Common Stock	15,500	$92.50	$1,433,676	129,083
2017-09-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	430	$0.00	$0	226,494
2017-09-22	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,166	$0.00	$0	0
2017-09-22	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,355	$0.00	$0	2,166
2017-09-22	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,166	$95.00	$205,770	47,944
2017-09-22	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	2,166	$37.46	$81,138	50,110
2017-09-22	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,355	$95.00	$128,725	47,944
2017-09-22	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	1,355	$37.46	$50,758	49,299
2017-09-15	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (right to buy) Common Stock	3,750	$0.00	$0	7,500
2017-09-15	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	3,750	$91.26	$342,225	15,910
2017-09-15	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	3,750	$38.59	$144,712	19,660
2017-06-23	Davis George Eric	EVP, General Counsel	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	9,844	$0.00	$0	30,000
2017-06-23	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	9,844	$96.60	$950,930	83,581
2017-06-23	Davis George Eric	EVP, General Counsel	Exercise / conversion M	Common Stock	9,844	$38.59	$379,880	93,425
2017-06-22	Mueller Brian	SVP, Corporate Controller	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	2,671	$0.00	$0	0
2017-06-22	Mueller Brian	SVP, Corporate Controller	Open-market sell S	Common Stock	2,671	$100.00	$267,100	12,885
2017-06-22	Mueller Brian	SVP, Corporate Controller	Exercise / conversion M	Common Stock	2,671	$21.51	$57,453	15,556
2017-06-19	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (right to buy) Common Stock	603	$0.00	$0	47,331
2017-06-19	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	603	$90.00	$54,270	136,422
2017-06-19	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	603	$37.46	$22,588	137,025
2017-06-16	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (right to buy) Common Stock	9,397	$0.00	$0	47,934
2017-06-16	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (right to buy) Common Stock	5,000	$0.00	$0	15,225
2017-06-16	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	9,397	$90.00	$845,730	136,422
2017-06-16	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	5,000	$90.00	$450,000	145,819
2017-06-16	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	9,397	$37.46	$352,012	150,819
2017-06-16	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	5,000	$26.49	$132,450	141,422
2017-06-09	Davis George Eric	EVP, General Counsel	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,775	$0.00	$0	0
2017-06-09	Davis George Eric	EVP, General Counsel	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,464	$0.00	$0	0
2017-06-09	Davis George Eric	EVP, General Counsel	Exercise / conversion M	Common Stock	3,775	$26.49	$100,000	83,581
2017-06-09	Davis George Eric	EVP, General Counsel	Exercise / conversion M	Common Stock	5,464	$21.51	$117,531	79,806
2017-06-07	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,004	$89.61	$89,968	47,944
2017-06-06	LAWLIS V BRYAN	Dir	Equity grant / award A · derivative	Stock Option (Right to buy) Common Stock	4,910	$0.00	$0	4,910
2017-06-06	LAWLIS V BRYAN	Dir	Equity grant / award A	Common Stock	2,050	$0.00	$0	15,910
2017-06-05	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	9,471	$91.04	$862,230	74,342
2017-06-02	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	1,801	$90.72	$163,387	23,303
2017-06-01	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	10,000
2017-06-01	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$87.53	$437,650	233,564
2017-06-01	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$17.33	$86,650	238,564
2017-05-31	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	7,423	$0.00	$0	15,000
2017-05-31	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	7,423	$88.29	$655,377	233,564
2017-05-31	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	7,423	$17.33	$128,641	240,987
2017-05-24	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	22,423
2017-05-24	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$88.38	$441,900	233,564
2017-05-24	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$17.33	$86,650	238,564
2017-05-17	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	27,423
2017-05-17	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$91.73	$458,650	233,564
2017-05-17	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$17.33	$86,650	238,564
2017-05-16	Davis George Eric	EVP, General Counsel	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	1,146	$0.00	$0	0
2017-05-16	Davis George Eric	EVP, General Counsel	Exercise / conversion M	Common Stock	1,146	$14.39	$16,491	85,301
2017-05-15	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Other disposed transaction F	Common Stock	1,722	$91.50	$157,563	25,104
2017-05-15	Davis George Eric	EVP, General Counsel	Other disposed transaction F	Common Stock	1,096	$91.50	$100,284	84,155
2017-05-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	32,423
2017-05-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$89.23	$446,150	238,496
2017-05-12	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$17.33	$86,650	243,496
2017-05-05	MEIER RICHARD A	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	7,500	$0.00	$0	0
2017-05-05	MEIER RICHARD A	Dir	Exercise / conversion M	Common Stock	7,500	$17.33	$129,975	34,260
2017-05-02	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	302	$96.74	$29,215	51,532
2017-04-28	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	155	$70.30	$10,897	26,826
2017-04-28	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Equity grant / award A	Common Stock	302	$70.30	$21,232	51,834
2017-04-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	47,423
2017-04-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$95.72	$478,600	238,194
2017-04-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$17.33	$86,650	243,194
2017-04-25	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	52,423
2017-04-25	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$94.00	$470,000	238,194
2017-04-25	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$17.33	$86,650	243,194
2017-04-04	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	3,000	$0.00	$0	114,000
2017-04-04	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,000	$14.39	$43,170	238,194
2017-03-29	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	3,890	$89.15	$346,794	51,532
2017-03-22	Davis George Eric	EVP, General Counsel	Equity grant / award A · derivative	Stock Option (Right to buy Common Stock)	36,280	$0.00	$0	36,820
2017-03-22	Davis George Eric	EVP, General Counsel	Equity grant / award A	Common Stock	11,220	$0.00	$0	84,949
2017-03-15	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	3,288	$92.50	$304,140	43,222
2017-03-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	67,423
2017-03-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$92.68	$463,400	206,364
2017-03-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$17.33	$86,650	211,364
2017-03-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	5,000	$0.00	$0	72,423
2017-03-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$91.09	$455,450	206,364
2017-03-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$17.33	$86,650	211,364
2017-03-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	6,000	$0.00	$0	77,423
2017-03-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	6,000	$90.18	$541,080	206,364
2017-03-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	6,000	$17.33	$103,980	212,364
2017-03-07	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	5,000	$90.56	$452,800	46,510
2017-03-06	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Open-market sell S	Common Stock	2,303	$93.32	$214,916	20,761
2017-03-03	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	1,749	$93.95	$164,319	51,510
2017-03-01	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy) Common Stock	7,500	$0.00	$0	0
2017-03-01	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	7,500	$95.00	$712,500	13,860
2017-03-01	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	7,500	$17.33	$129,975	21,360
2017-03-01	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Open-market sell S	Common Stock	5,000	$94.50	$472,500	25,347
2017-02-28	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (right to buy) Common Stock	30,000	$0.00	$0	21,700
2017-02-28	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Open-market sell S	Common Stock	30,000	$94.00	$2,820,000	30,347
2017-02-28	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Exercise / conversion M	Common Stock	30,000	$63.10	$1,893,000	60,347
2017-02-24	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	12,247	$0.00	$0	30,347
2017-01-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	5,000	$0.00	$0	83,423
2017-01-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$84.00	$420,000	170,682
2017-01-26	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$17.33	$86,650	175,682
2017-01-25	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	5,000	$0.00	$0	88,423
2017-01-25	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$84.44	$422,200	170,682
2017-01-25	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	5,000	$17.33	$86,650	175,682
2017-01-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	4,000	$0.00	$0	93,423
2017-01-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$89.84	$359,360	170,682
2017-01-11	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$17.33	$69,320	174,682
2017-01-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	4,000	$0.00	$0	97,423
2017-01-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$91.31	$365,240	170,682
2017-01-10	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$17.33	$69,320	174,682
2017-01-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	4,000	$0.00	$0	101,423
2017-01-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$89.79	$359,160	170,682
2017-01-09	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$17.33	$69,320	174,682
2017-01-09	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Open-market sell S	Common Stock	5,000	$90.00	$450,000	18,100
2017-01-06	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	4,000	$0.00	$0	105,423
2017-01-06	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$87.19	$348,760	170,682
2017-01-06	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$17.33	$69,320	174,682
2016-12-30	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	4,000	$0.00	$0	109,423
2016-12-30	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$83.35	$333,400	170,682
2016-12-30	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$17.33	$69,320	174,682
2016-12-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	4,000	$0.00	$0	113,423
2016-12-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	4,000	$83.84	$335,360	170,682
2016-12-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	4,000	$17.33	$69,320	174,682
2016-11-25	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M · derivative	Stock Option (Right to buy Common Stock)	15,000	$0.00	$0	35,225
2016-11-25	FUCHS HENRY J	President, Worldwide R&D	Open-market sell S	Common Stock	15,000	$87.40	$1,310,988	113,878
2016-11-25	FUCHS HENRY J	President, Worldwide R&D	Exercise / conversion M	Common Stock	15,000	$26.49	$397,350	128,878
2016-11-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	69,743	$0.00	$0	140,513
2016-11-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	69,743	$85.69	$5,976,515	170,682
2016-11-22	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	69,743	$26.49	$1,847,492	240,425
2016-11-21	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	69,744	$0.00	$0	210,256
2016-11-21	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	69,744	$87.56	$6,106,478	170,682
2016-11-21	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	69,744	$26.49	$1,847,519	240,426
2016-11-18	Davis George Eric	EVP, General Counsel	Exercise / conversion M · derivative	Stock Option (Right to buy) Common Stock	5,000	$38.59	$192,950	42,344
2016-11-18	Davis George Eric	EVP, General Counsel	Open-market sell S	Common Stock	5,000	$90.42	$452,100	70,798
2016-11-18	Davis George Eric	EVP, General Counsel	Exercise / conversion M	Common Stock	5,000	$38.59	$192,950	75,798
2016-11-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	41,670	$0.00	$0	0
2016-11-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	41,670	$90.97	$3,790,795	323,368
2016-11-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	41,670	$17.54	$730,892	365,038
2016-11-09	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Open-market sell S	Common Stock	20,000	$90.61	$1,812,206	23,100
2016-11-09	LAWLIS V BRYAN	Dir	Exercise / conversion M · derivative	Stock Option (Right to buy) Common Stock	7,500	$0.00	$0	7,500
2016-11-09	LAWLIS V BRYAN	Dir	Open-market sell S	Common Stock	7,500	$95.00	$712,500	13,860
2016-11-09	LAWLIS V BRYAN	Dir	Exercise / conversion M	Common Stock	7,500	$17.33	$129,975	21,360
2016-11-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	70,000	$0.00	$0	140,000
2016-11-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	70,000	$82.83	$5,797,806	323,368
2016-11-08	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	70,000	$21.51	$1,505,700	393,368
2016-11-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	70,000	$0.00	$0	210,000
2016-11-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	70,000	$82.52	$5,776,435	323,368
2016-11-07	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	70,000	$21.51	$1,505,700	393,368
2016-10-31	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Equity grant / award A	Common Stock	156	$68.44	$10,677	43,100
2016-10-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	60,000	$0.00	$0	117,000
2016-10-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	60,000	$81.27	$4,875,990	323,368
2016-10-28	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	60,000	$14.39	$863,400	383,368
2016-10-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	60,000	$0.00	$0	177,000
2016-10-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	60,000	$81.34	$4,880,448	323,368
2016-10-27	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	60,000	$14.39	$863,400	383,368
2016-10-17	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	41,666	$0.00	$0	41,670
2016-10-17	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	41,666	$84.39	$3,516,227	323,368
2016-10-17	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	41,666	$17.54	$730,822	365,034
2016-10-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	11,000	$0.00	$0	11,000
2016-10-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	11,000	$86.89	$955,814	323,368
2016-10-14	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	11,000	$17.86	$196,460	334,368
2016-10-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	53,125	$0.00	$0	212,500
2016-10-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	53,125	$86.98	$4,620,563	323,368
2016-10-13	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	53,125	$38.59	$2,050,094	376,493
2016-10-07	Davis George Eric	EVP, General Counsel	Equity grant / award G	Common Stock	360	$0.00	$0	70,798
2016-09-30	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	53,125	$0.00	$0	265,625
2016-09-30	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	53,125	$92.02	$4,888,780	378,584
2016-09-30	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	53,125	$38.59	$2,050,094	431,709
2016-09-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	53,125	$0.00	$0	318,750
2016-09-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	53,125	$93.65	$4,974,901	378,584
2016-09-29	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	53,125	$38.59	$2,050,094	431,709
2016-09-27	Ajer Jeffrey Robert	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	18,467	$95.61	$1,765,648	41,342
2016-09-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	41,666	$0.00	$0	83,336
2016-09-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	53,125	$0.00	$0	371,875
2016-09-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	41,666	$95.97	$3,998,561	378,584
2016-09-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	41,666	$17.54	$730,822	420,250
2016-09-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	53,125	$95.25	$5,060,039	378,584
2016-09-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	53,125	$38.59	$2,050,094	431,709
2016-09-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	42,577	$0.00	$0	117,423
2016-09-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	42,577	$94.85	$4,038,360	378,584
2016-09-15	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	42,577	$17.33	$737,859	421,161
2016-08-26	FUCHS HENRY J	EVP, Chief Medical Officer	Exercise / conversion M · derivative	Common Stock (Right to buy Common Stock)	15,000	$0.00	$0	50,225
2016-08-26	FUCHS HENRY J	EVP, Chief Medical Officer	Open-market sell S	Common Stock	15,000	$95.06	$1,425,924	113,878
2016-08-26	FUCHS HENRY J	EVP, Chief Medical Officer	Exercise / conversion M	Common Stock	15,000	$26.49	$397,350	128,878
2016-08-24	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	200	$0.00	$0	377,484
2016-08-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (right to buy Common Stock)	41,666	$0.00	$0	125,002
2016-08-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Open-market sell S	Common Stock	41,666	$91.49	$3,811,868	378,584
2016-08-16	BIENAIME JEAN JACQUES	Chief Executive Officer	Exercise / conversion M	Common Stock	41,666	$17.54	$730,822	420,250
2016-08-04	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	500	$0.00	$0	377,684
2016-08-03	BIENAIME JEAN JACQUES	Chief Executive Officer	Equity grant / award G	Common Stock	400	$0.00	$0	378,184
2016-08-01	SPIEGELMAN DANIEL K	EVP, Chief Financial Officer	Open-market sell S	Common Stock	4,000	$99.33	$397,320	42,944
2016-07-15	FALBERG KATHRYN E	Dir	Equity grant / award A · derivative	Stock Option (right to buy Common Stock)	9,880	$0.00	$0	9,880
2016-07-15	FALBERG KATHRYN E	Dir	Equity grant / award A	Common Stock	2,640	$0.00	$0	2,640
2016-06-06	LAWLIS V BRYAN	Dir	Other acquired transaction J	Common Stock	0	$0.00	—	13,360

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count