Financial Metrics

EXEL EXELIXIS, INC.

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-0.26	—	USD/shares	10-Q	2017-05-01
Quarterly	2016-06-30	-0.15	+42.3%	USD/shares	10-Q	2017-08-02
Quarterly	2016-09-30	-0.04	+73.3%	USD/shares	10-Q	2017-11-01
Quarterly	2017-03-31	0.05	+225.0%	USD/shares	10-Q	2018-05-02
Quarterly	2017-06-30	0.06	+20.0%	USD/shares	10-Q	2018-08-01
Quarterly	2017-09-29	0.26	+333.3%	USD/shares	10-Q	2018-11-01
Quarterly	2017-09-30	0.26	+0.0%	USD/shares	10-Q	2017-11-01
Quarterly	2018-03-30	0.37	+42.3%	USD/shares	10-Q	2019-05-01
Quarterly	2018-06-29	0.28	-24.3%	USD/shares	10-Q	2019-07-31
Quarterly	2018-09-28	0.41	+46.4%	USD/shares	10-Q	2019-10-30
Quarterly	2019-03-29	0.24	-41.5%	USD/shares	10-Q	2020-05-05
Quarterly	2019-06-28	0.25	+4.2%	USD/shares	10-Q	2020-08-06
Quarterly	2019-09-27	0.31	+24.0%	USD/shares	10-Q	2020-11-05
Quarterly	2020-04-03	0.15	-51.6%	USD/shares	10-Q	2021-05-06
Quarterly	2020-07-03	0.21	+40.0%	USD/shares	10-Q	2021-08-05
Quarterly	2020-10-02	-0.1	-147.6%	USD/shares	10-Q	2021-11-02
Quarterly	2021-04-02	0.0	+100.0%	USD/shares	10-Q	2022-05-10
Quarterly	2021-07-02	0.3	—	USD/shares	10-Q	2022-08-09
Quarterly	2021-10-01	0.12	-60.0%	USD/shares	10-Q	2022-11-01
Quarterly	2022-04-01	0.21	+75.0%	USD/shares	10-Q	2023-05-09
Quarterly	2022-07-01	0.22	+4.8%	USD/shares	10-Q	2023-08-01
Quarterly	2022-09-30	0.23	+4.5%	USD/shares	10-Q	2023-11-01
Quarterly	2023-03-31	0.12	-47.8%	USD/shares	10-Q	2024-04-30
Quarterly	2023-06-30	0.25	+108.3%	USD/shares	10-Q	2024-08-06
Quarterly	2023-09-29	0.0	-100.0%	USD/shares	10-Q	2024-10-29
Quarterly	2024-03-29	0.12	—	USD/shares	10-Q	2025-05-13
Quarterly	2024-06-28	0.77	+541.7%	USD/shares	10-Q	2025-07-28
Quarterly	2024-09-27	0.4	-48.1%	USD/shares	10-Q	2025-11-04
Quarterly	2025-04-04	0.55	+37.5%	USD/shares	10-Q	2025-05-13
Quarterly	2025-07-04	0.65	+18.2%	USD/shares	10-Q	2025-07-28
Quarterly	2025-10-03	0.69	+6.2%	USD/shares	10-Q	2025-11-04
Annual	2016-12-30	-0.28	—	USD/shares	10-K	2019-02-22
Annual	2017-12-29	0.49	+275.0%	USD/shares	10-K	2020-02-25
Annual	2018-12-28	2.21	+351.0%	USD/shares	10-K	2021-02-11
Annual	2019-09-27	0.31	-86.0%	USD/shares	10-K	2021-02-11
Annual	2020-10-02	-0.1	-132.3%	USD/shares	10-K	2021-02-11
Annual	2021-12-31	0.72	+820.0%	USD/shares	10-K	2024-02-06
Annual	2022-12-30	0.56	-22.2%	USD/shares	10-K	2025-02-11
Annual	2023-12-29	0.65	+16.1%	USD/shares	10-K	2026-02-10
Annual	2025-01-03	1.76	+170.8%	USD/shares	10-K	2026-02-10
Annual	2026-01-02	2.78	+58.0%	USD/shares	10-K	2026-02-10

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	388656000.0	—	USD	10-Q	2016-05-04
Quarterly	2016-06-30	396055000.0	+1.9%	USD	10-Q	2016-08-03
Quarterly	2016-09-30	190858000.0	-51.8%	USD	10-Q	2016-11-03
Quarterly	2016-12-31	189122000.0	-0.9%	USD	10-Q	2017-11-01
Quarterly	2017-03-31	113349000.0	-40.1%	USD	10-Q	2017-05-01
Quarterly	2017-06-30	0.0	-100.0%	USD	10-Q	2017-08-02
Quarterly	2017-09-30	0.0	—	USD	10-Q	2017-11-01
Annual	2016-12-31	189122000.0	—	USD	10-K	2017-02-27
Annual	2017-12-29	0.0	-100.0%	USD	10-K	2018-02-26

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	682000.0	—	USD	10-Q	2017-05-01
Quarterly	2016-06-30	1083000.0	+58.8%	USD	10-Q	2017-08-02
Quarterly	2016-09-30	1116000.0	+3.0%	USD	10-Q	2017-11-01
Quarterly	2017-03-31	804000.0	-28.0%	USD	10-Q	2018-05-02
Quarterly	2017-06-30	2298000.0	+185.8%	USD	10-Q	2018-08-01
Quarterly	2017-09-29	3449000.0	+50.1%	USD	10-Q	2018-11-01
Quarterly	2017-09-30	3449000.0	+0.0%	USD	10-Q	2017-11-01
Quarterly	2018-03-30	2947000.0	-14.6%	USD	10-Q	2019-05-01
Quarterly	2018-06-29	15182000.0	+415.2%	USD	10-Q	2019-07-31
Quarterly	2018-09-28	30403000.0	+100.3%	USD	10-Q	2019-10-30
Quarterly	2019-03-29	2307000.0	-92.4%	USD	10-Q	2020-05-05
Quarterly	2019-06-28	3516000.0	+52.4%	USD	10-Q	2020-08-06
Quarterly	2019-09-27	5575000.0	+58.6%	USD	10-Q	2020-11-05
Quarterly	2020-04-03	2961000.0	-46.9%	USD	10-Q	2021-05-06
Quarterly	2020-07-03	9925000.0	+235.2%	USD	10-Q	2021-08-05
Quarterly	2020-10-02	16055000.0	+61.8%	USD	10-Q	2021-11-02
Quarterly	2021-04-02	13557000.0	-15.6%	USD	10-Q	2022-05-10
Quarterly	2021-07-02	33768000.0	+149.1%	USD	10-Q	2022-08-09
Quarterly	2021-10-01	48265000.0	+42.9%	USD	10-Q	2022-11-01
Quarterly	2022-04-01	5609000.0	-88.4%	USD	10-Q	2023-05-09
Quarterly	2022-07-01	12946000.0	+130.8%	USD	10-Q	2023-08-01
Quarterly	2022-09-30	17989000.0	+39.0%	USD	10-Q	2023-11-01
Quarterly	2023-03-31	12024000.0	-33.2%	USD	10-Q	2024-04-30
Quarterly	2023-06-30	17961000.0	+49.4%	USD	10-Q	2024-08-06
Quarterly	2023-09-29	27334000.0	+52.2%	USD	10-Q	2024-10-29
Quarterly	2024-03-29	9691000.0	-64.5%	USD	10-Q	2025-05-13
Quarterly	2024-06-28	16261000.0	+67.8%	USD	10-Q	2025-07-28
Quarterly	2024-09-27	24458000.0	+50.4%	USD	10-Q	2025-11-04
Quarterly	2025-04-04	2952000.0	-87.9%	USD	10-Q	2025-05-13
Quarterly	2025-07-04	5790000.0	+96.1%	USD	10-Q	2025-07-28
Quarterly	2025-10-03	7272000.0	+25.6%	USD	10-Q	2025-11-04
Annual	2016-12-31	1703000.0	—	USD	10-K	2017-02-27
Annual	2017-12-29	21143000.0	+1141.5%	USD	10-K	2020-02-25
Annual	2018-12-28	33297000.0	+57.5%	USD	10-K	2021-02-11
Annual	2020-01-03	12834000.0	-61.5%	USD	10-K	2022-02-18
Annual	2021-12-31	54225000.0	+322.5%	USD	10-K	2024-02-06
Annual	2022-12-30	27706000.0	-48.9%	USD	10-K	2025-02-11
Annual	2023-12-29	40469000.0	+46.1%	USD	10-K	2026-02-10
Annual	2025-01-03	28435000.0	-29.7%	USD	10-K	2026-02-10
Annual	2026-01-02	8429000.0	-70.4%	USD	10-K	2026-02-10

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	228304000.0	—	shares	10-Q	2017-05-01
Quarterly	2016-06-30	229310000.0	+0.4%	shares	10-Q	2017-08-02
Quarterly	2016-09-30	256319000.0	+11.8%	shares	10-Q	2017-11-01
Quarterly	2017-03-31	309535000.0	+20.8%	shares	10-Q	2018-05-02
Quarterly	2017-06-30	311219000.0	+0.5%	shares	10-Q	2018-08-01
Quarterly	2017-09-29	312940000.0	+0.6%	shares	10-Q	2018-11-01
Quarterly	2017-09-30	312940000.0	+0.0%	shares	10-Q	2017-11-01
Quarterly	2018-03-30	313691000.0	+0.2%	shares	10-Q	2019-05-01
Quarterly	2018-06-29	312241000.0	-0.5%	shares	10-Q	2019-07-31
Quarterly	2018-09-28	312346000.0	+0.0%	shares	10-Q	2019-10-30
Quarterly	2019-03-29	314644000.0	+0.7%	shares	10-Q	2020-05-05
Quarterly	2019-06-28	314911000.0	+0.1%	shares	10-Q	2020-08-06
Quarterly	2019-09-27	315453000.0	+0.2%	shares	10-Q	2020-11-05
Quarterly	2020-04-03	315839000.0	+0.1%	shares	10-Q	2021-05-06
Quarterly	2020-07-03	318144000.0	+0.7%	shares	10-Q	2021-08-05
Quarterly	2020-10-02	309116000.0	-2.8%	shares	10-Q	2021-11-02
Quarterly	2021-04-02	321287000.0	+3.9%	shares	10-Q	2022-05-10
Quarterly	2021-07-02	322941000.0	+0.5%	shares	10-Q	2022-08-09
Quarterly	2021-10-01	322022000.0	-0.3%	shares	10-Q	2022-11-01
Quarterly	2022-04-01	323289000.0	+0.4%	shares	10-Q	2023-05-09
Quarterly	2022-07-01	324904000.0	+0.5%	shares	10-Q	2023-08-01
Quarterly	2022-09-30	325066000.0	+0.0%	shares	10-Q	2023-11-01
Quarterly	2023-03-31	326279000.0	+0.4%	shares	10-Q	2024-04-30
Quarterly	2023-06-30	327305000.0	+0.3%	shares	10-Q	2024-08-06
Quarterly	2023-09-29	319247000.0	-2.5%	shares	10-Q	2024-10-29
Quarterly	2024-03-29	305530000.0	-4.3%	shares	10-Q	2025-05-13
Quarterly	2024-06-28	293974000.0	-3.8%	shares	10-Q	2025-07-28
Quarterly	2024-09-27	291478000.0	-0.8%	shares	10-Q	2025-11-04
Quarterly	2025-04-04	288177000.0	-1.1%	shares	10-Q	2025-05-13
Quarterly	2025-07-04	284393000.0	-1.3%	shares	10-Q	2025-07-28
Quarterly	2025-10-03	278535000.0	-2.1%	shares	10-Q	2025-11-04
Annual	2016-12-31	250531000.0	—	shares	10-K	2017-02-27
Annual	2017-12-29	312003000.0	+24.5%	shares	10-K	2020-02-25
Annual	2018-12-28	312803000.0	+0.3%	shares	10-K	2021-02-11
Annual	2020-01-03	315009000.0	+0.7%	shares	10-K	2022-02-18
Annual	2021-12-31	322359000.0	+2.3%	shares	10-K	2024-02-06
Annual	2022-12-30	324556000.0	+0.7%	shares	10-K	2025-02-11
Annual	2023-12-29	321464000.0	-1.0%	shares	10-K	2026-02-10
Annual	2025-01-03	296132000.0	-7.9%	shares	10-K	2026-02-10
Annual	2026-01-02	281863000.0	-4.8%	shares	10-K	2026-02-10

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

Total Liabilities (latest annual)

683,104,000

Current Liabilities (latest annual)

405,644,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	0.3797	—	ratio	10-Q	2017-05-01
Quarterly	2016-06-30	0.1872	-50.7%	ratio	10-Q	2017-08-02
Quarterly	2016-09-30	-0.3524	-288.3%	ratio	10-Q	2017-11-01
Quarterly	2017-03-31	0.1395	+139.6%	ratio	10-Q	2018-05-02
Quarterly	2017-06-30	0.1189	-14.8%	ratio	10-Q	2018-08-01
Quarterly	2017-09-30	0.3409	+186.8%	ratio	10-Q	2017-11-01
Quarterly	2018-03-30	0.1729	-49.3%	ratio	10-Q	2019-05-01
Quarterly	2018-06-29	0.1129	-34.7%	ratio	10-Q	2019-07-31
Quarterly	2018-09-28	0.1382	+22.5%	ratio	10-Q	2019-10-30
Quarterly	2019-03-29	0.0547	-60.4%	ratio	10-Q	2020-05-05
Quarterly	2019-06-28	0.0531	-2.9%	ratio	10-Q	2020-08-06
Quarterly	2019-09-27	0.0608	+14.4%	ratio	10-Q	2020-11-05
Quarterly	2020-04-03	0.0278	-54.2%	ratio	10-Q	2021-05-06
Quarterly	2020-07-03	0.0364	+31.0%	ratio	10-Q	2021-08-05
Quarterly	2020-10-02	-0.0173	-147.5%	ratio	10-Q	2021-11-02
Quarterly	2021-04-02	0.0008	+104.8%	ratio	10-Q	2022-05-10
Quarterly	2021-07-02	0.0470	+5514.5%	ratio	10-Q	2022-08-09
Quarterly	2021-10-01	0.0181	-61.5%	ratio	10-Q	2022-11-01
Quarterly	2022-04-01	0.0299	+65.3%	ratio	10-Q	2023-05-09
Quarterly	2022-07-01	0.0296	-1.1%	ratio	10-Q	2023-08-01
Quarterly	2022-09-30	0.0294	-0.6%	ratio	10-Q	2023-11-01
Quarterly	2023-03-31	0.0157	-46.7%	ratio	10-Q	2024-04-30
Quarterly	2023-06-30	0.0321	+105.0%	ratio	10-Q	2024-08-06
Quarterly	2023-09-29	0.0004	-98.6%	ratio	10-Q	2024-10-29
Quarterly	2024-03-29	0.0175	+3854.7%	ratio	10-Q	2025-05-13
Quarterly	2024-06-28	0.1067	+508.3%	ratio	10-Q	2025-07-28
Quarterly	2024-09-27	0.0518	-51.4%	ratio	10-Q	2025-11-04
Quarterly	2025-04-04	0.0749	+44.5%	ratio	10-Q	2025-05-13
Quarterly	2025-07-04	0.0909	+21.4%	ratio	10-Q	2025-07-28
Quarterly	2025-10-03	0.0896	-1.4%	ratio	10-Q	2025-11-04
Annual	2016-12-31	0.3932	—	ratio	10-K	2017-02-27
Annual	2018-12-28	0.5360	+36.3%	ratio	10-K	2021-02-11
Annual	2021-12-31	0.1045	-80.5%	ratio	10-K	2024-02-06
Annual	2022-12-30	0.0733	-29.9%	ratio	10-K	2025-02-11
Annual	2023-12-29	0.0918	+25.3%	ratio	10-K	2026-02-10
Annual	2025-01-03	0.2323	+153.1%	ratio	10-K	2026-02-10
Annual	2026-01-02	0.3621	+55.9%	ratio	10-K	2026-02-10

8-K Material Event Details

60 filings · 103 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

886 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-02-26	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	160,437	$0.00	$0	1,614,552
2026-02-26	Aftab Dana	EVP, Research and Development	Equity grant / award A	Common Stock	52,018	$0.00	$0	668,124
2026-02-24	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	100,278	$0.00	$0	1,989,956
2026-02-19	Aftab Dana	EVP, Research and Development	Open-market sell S	Common Stock	29,873	$44.35	$1,324,868	664,024
2026-02-18	Smith Julie	Dir	Exercise / conversion M · derivative	Option (right to buy)	20,030	$0.00	$0	0
2026-02-18	Smith Julie	Dir	Exercise / conversion M · derivative	Option (right to buy)	44,087	$0.00	$0	0
2026-02-18	Smith Julie	Dir	Open-market sell S	Common Stock	20,030	$44.30	$887,329	20,590
2026-02-18	Smith Julie	Dir	Exercise / conversion M	Common Stock	20,030	$21.69	$434,451	40,620
2026-02-18	Smith Julie	Dir	Open-market sell S	Common Stock	44,087	$44.50	$1,961,872	20,590
2026-02-18	Smith Julie	Dir	Exercise / conversion M	Common Stock	44,087	$19.39	$854,847	64,677
2026-02-18	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	20,634	$0.00	$0	0
2026-02-18	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	99,574	$44.01	$4,382,252	279,942
2026-02-18	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	20,634	$19.77	$407,934	379,516
2026-02-17	Senner Christopher J.	EVP and CFO	Open-market sell S	Common Stock	30,617	$43.67	$1,337,044	976,092
2026-02-17	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	64,778	$43.50	$2,817,843	381,908
2026-02-17	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	3,036	$43.84	$133,098	446,686
2026-02-17	Smith Julie	Dir	Exercise / conversion M · derivative	Option (right to buy)	42,422	$0.00	$0	0
2026-02-17	Smith Julie	Dir	Open-market sell S	Common Stock	42,422	$43.33	$1,838,145	20,590
2026-02-17	Smith Julie	Dir	Exercise / conversion M	Common Stock	42,422	$18.19	$771,656	63,012
2026-02-15	Senner Christopher J.	EVP and CFO	Other disposed transaction F	Common Stock	35,870	$43.92	$1,575,410	1,006,709
2026-02-15	Haley Patrick J.	EVP, Commercial	Other disposed transaction F	Common Stock	31,483	$43.92	$1,382,733	449,722
2026-02-13	Senner Christopher J.	EVP and CFO	Open-market sell S	Common Stock	34,278	$43.00	$1,473,954	1,042,579
2026-01-15	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	139,524	$45.23	$6,310,671	1,825,241
2026-01-15	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	548,073	$0.00	$0	1,964,765
2025-12-03	Hefti Brenda	SVP and General Counsel	Equity grant / award A	Common Stock	30,170	$0.00	$0	120,611
2025-11-25	JOHNSON DAVID EDWARD	Dir	Open-market buy P	Common Stock	27,532	$43.12	$1,187,235	1,553,262
2025-11-21	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	28,043	$42.58	$1,194,071	374,029
2025-11-21	Aftab Dana	EVP, Research and Development	Equity grant / award G	Common Stock	24,000	$0.00	$0	640,778
2025-11-20	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	10,648	$41.77	$444,767	0
2025-11-20	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	23,539	$41.93	$986,990	0
2025-11-20	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	10,000	$42.11	$421,100	402,072
2025-11-17	Oliver Bob	Dir	Equity grant / award G	Common Stock	1,044	$0.00	$0	42,282
2025-11-12	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	80,000	$0.00	$0	1,714,404
2025-11-12	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	101,548	$0.00	$0	1,794,404
2025-11-12	PAPADOPOULOS STELIOS	Dir	Open-market sell S	Common Stock	100,000	$43.55	$4,355,000	1,189,228
2025-11-11	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	160,000	$0.00	$0	1,692,856
2025-10-08	Aftab Dana	EVP, Research & Development	Equity grant / award A	Common Stock	50,673	$0.00	$0	713,161
2025-06-03	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	7,535	$43.09	$324,683	358,882
2025-06-02	Eckhardt Sue Gail	Dir	Open-market sell S	Common Stock	4	$43.67	$175	21,380
2025-06-02	Eckhardt Sue Gail	Dir	Open-market sell S	Common Stock	18,834	$42.74	$804,965	21,384
2025-05-29	JOHNSON DAVID EDWARD	Dir	Equity grant / award A · derivative	Option (right to buy)	21,464	$0.00	$0	21,464
2025-05-21	Heyman Tomas J.	Dir	Open-market sell S	Common Stock	4,544	$44.29	$201,254	32,470
2025-05-20	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	34,387	$44.06	$1,515,091	412,072
2025-05-16	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	87,871	$0.00	$0	1,852,856
2025-05-16	POSTE GEORGE	Dir	Exercise / conversion M · derivative	Option (right to buy)	20,634	$0.00	$0	0
2025-05-16	POSTE GEORGE	Dir	Open-market sell S	Common Stock	20,634	$45.99	$948,958	169,020
2025-05-16	POSTE GEORGE	Dir	Exercise / conversion M	Common Stock	20,634	$19.77	$407,934	189,654
2025-05-15	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	104,769	$44.65	$4,677,936	1,606,111
2025-05-15	Aftab Dana	CSO/EVP Disc & Trans Research	Other disposed transaction F	Common Stock	30,693	$44.65	$1,370,442	662,488
2025-05-14	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	308,365	$0.00	$0	0
2025-05-14	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	220,494	$44.65	$9,845,057	1,710,880
2025-05-14	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	308,365	$18.80	$5,797,262	1,931,374
2025-05-01	Aftab Dana	CSO/EVP Disc & Trans Research	Open-market sell S	Common Stock	1,508	$39.00	$58,812	693,181
2025-03-31	Peterson Amy C.	EVP Prod Dev & Med Aff & CMO	Equity grant / award A	Common Stock	159,383	$0.00	$0	506,472
2025-03-03	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	10,000	$38.80	$388,000	341,028
2025-02-28	Smith Julie	Dir	Exercise / conversion M · derivative	Option (right to buy)	19,294	$0.00	$0	0
2025-02-28	Smith Julie	Dir	Open-market sell S	Common Stock	19,294	$37.62	$725,840	10,778
2025-02-28	Smith Julie	Dir	Exercise / conversion M	Common Stock	19,294	$19.77	$381,442	30,072
2025-02-28	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,874	$0.00	$0	0
2025-02-28	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	8,768	$37.80	$331,430	356,605
2025-02-28	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	15,874	$20.50	$325,417	365,373
2025-02-27	Smith Julie	Dir	Exercise / conversion M · derivative	Option (right to buy)	23,347	$0.00	$0	19,294
2025-02-27	Smith Julie	Dir	Exercise / conversion M · derivative	Option (right to buy)	31,167	$0.00	$0	0
2025-02-27	Smith Julie	Dir	Open-market sell S	Common Stock	54,514	$38.13	$2,078,619	10,778
2025-02-27	Smith Julie	Dir	Exercise / conversion M	Common Stock	23,347	$19.77	$461,570	65,292
2025-02-27	Smith Julie	Dir	Exercise / conversion M	Common Stock	31,167	$20.50	$638,924	41,945
2025-02-26	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	184,909	$0.00	$0	1,033,290
2025-02-25	Oliver Bob	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,147	$0.00	$0	21,206
2025-02-25	Oliver Bob	Dir	Open-market sell S	Common Stock	18,647	$37.25	$694,601	33,514
2025-02-25	Oliver Bob	Dir	Exercise / conversion M	Common Stock	15,147	$19.28	$292,034	52,161
2025-02-24	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	52,636	$36.98	$1,946,479	303,310
2025-02-15	Senner Christopher J.	EVP and CFO	Other disposed transaction F	Common Stock	21,591	$35.00	$755,685	779,607
2025-02-14	Beckerle Mary C	Dir	Exercise / conversion M · derivative	Option (right to buy)	8,354	$0.00	$0	22,494
2025-02-14	Beckerle Mary C	Dir	Open-market sell S	Common Stock	3,856	$34.90	$134,574	30,406
2025-02-14	Beckerle Mary C	Dir	Open-market sell S	Common Stock	8,354	$34.87	$291,304	34,262
2025-02-14	Beckerle Mary C	Dir	Exercise / conversion M	Common Stock	8,354	$23.24	$194,147	42,616
2025-01-16	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	120,244	$37.27	$4,481,494	1,089,936
2025-01-16	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	473,226	$0.00	$0	1,210,180
2024-12-20	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	179,788	$0.00	$0	1,587,000
2024-11-29	Hessekiel Jeffrey	EVP & General Counsel	Equity grant / award G	Common Stock	15,000	$0.00	$0	471,059
2024-11-29	Hessekiel Jeffrey	EVP & General Counsel	Open-market sell S	Common Stock	60,000	$36.67	$2,200,200	486,059
2024-11-27	Hessekiel Jeffrey	EVP & General Counsel	Exercise / conversion M · derivative	Option (right to buy)	129,314	$0.00	$0	0
2024-11-27	Hessekiel Jeffrey	EVP & General Counsel	Other disposed transaction F	Common Stock	98,908	$35.93	$3,553,764	546,059
2024-11-27	Hessekiel Jeffrey	EVP & General Counsel	Exercise / conversion M	Common Stock	129,314	$18.80	$2,431,103	644,967
2024-11-22	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	10,000	$35.27	$352,700	278,665
2024-11-15	Senner Christopher J.	EVP and CFO	Other disposed transaction F	Common Stock	17,506	$35.05	$613,585	704,174
2024-11-05	Aftab Dana	CSO/EVP Disc & Trans Research	Exercise / conversion M · derivative	Option (right to buy)	96,986	$0.00	$0	0
2024-11-05	Aftab Dana	CSO/EVP Disc & Trans Research	Open-market sell S	Common Stock	96,986	$35.00	$3,394,510	498,945
2024-11-05	Aftab Dana	CSO/EVP Disc & Trans Research	Exercise / conversion M	Common Stock	96,986	$18.80	$1,823,337	595,931
2024-11-01	Hessekiel Jeffrey	EVP & General Counsel	Open-market sell S	Common Stock	50,000	$34.13	$1,706,500	530,325
2024-10-31	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	46,000	$0.00	$0	1,407,212
2024-10-30	Aftab Dana	CSO/EVP Disc & Trans Research	Open-market sell S	Common Stock	1,162	$31.40	$36,487	498,945
2024-10-28	Hessekiel Jeffrey	EVP & General Counsel	Open-market sell S	Common Stock	25,000	$28.39	$709,750	580,325
2024-10-03	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	16,298	$0.00	$0	1,453,212
2024-10-02	Haley Patrick J.	EVP, Commercial	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	0
2024-10-02	Haley Patrick J.	EVP, Commercial	Other disposed transaction F	Common Stock	96,111	$26.50	$2,546,942	344,925
2024-10-02	Haley Patrick J.	EVP, Commercial	Exercise / conversion M	Common Stock	100,000	$24.41	$2,441,000	441,036
2024-10-01	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	480,000	$0.00	$0	0
2024-10-01	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	463,702	$26.30	$12,195,363	980,682
2024-10-01	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	480,000	$24.41	$11,716,800	1,444,384
2024-09-23	Hessekiel Jeffrey	EVP & General Counsel	Open-market sell S	Common Stock	25,000	$26.38	$659,500	605,325
2024-08-26	Hessekiel Jeffrey	EVP, General Counsel & Sec	Exercise / conversion M · derivative	Option (right to buy)	20,000	$0.00	$0	0
2024-08-26	Hessekiel Jeffrey	EVP, General Counsel & Sec	Open-market sell S	Common Stock	20,000	$25.79	$515,800	630,325
2024-08-26	Hessekiel Jeffrey	EVP, General Counsel & Sec	Exercise / conversion M	Common Stock	20,000	$24.41	$488,200	650,325
2024-08-14	Freire Maria C	Dir	Open-market sell S	Common Stock	8,250	$26.56	$219,120	91,007
2024-08-13	Smith Julie	Dir	Other disposed transaction J	Common Stock	4,682	$0.00	$0	10,778
2024-08-12	Aftab Dana	CSO/EVP Disc & Trans Research	Open-market sell S	Common Stock	20,883	$27.06	$565,094	500,107
2024-08-09	Senner Christopher J.	EVP and CFO	Exercise / conversion M · derivative	Option (right to buy)	125,000	$0.00	$0	0
2024-08-09	Senner Christopher J.	EVP and CFO	Open-market sell S	Common Stock	125,000	$27.19	$3,398,750	721,680
2024-08-09	Senner Christopher J.	EVP and CFO	Exercise / conversion M	Common Stock	125,000	$24.41	$3,051,250	846,680
2024-08-08	POSTE GEORGE	Dir	Open-market sell S	Common Stock	33,725	$26.89	$906,865	199,020
2024-08-07	Aftab Dana	CSO/EVP Disc & Trans Research	Exercise / conversion M · derivative	Option (right to buy)	95,000	$0.00	$0	0
2024-08-07	Aftab Dana	CSO/EVP Disc & Trans Research	Open-market sell S	Common Stock	95,000	$25.00	$2,375,000	520,990
2024-08-07	Aftab Dana	CSO/EVP Disc & Trans Research	Exercise / conversion M	Common Stock	95,000	$24.41	$2,318,950	615,990
2024-06-04	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	8,287	$22.00	$182,314	349,499
2024-05-31	PAPADOPOULOS STELIOS	Dir	Equity grant / award A	Common Stock	18,838	$0.00	$0	1,279,416
2024-05-30	JOHNSON DAVID EDWARD	Dir	Open-market buy P	Common Stock	225,000	$20.76	$4,670,055	1,525,730
2024-05-28	JOHNSON DAVID EDWARD	Dir	Open-market buy P	Common Stock	200,000	$20.32	$4,063,900	1,300,730
2024-05-21	Smith Julie	Dir	Open-market sell S	Common Stock	27,280	$21.12	$576,154	5,445
2024-05-20	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M · derivative	Option (right to buy)	11,686	$0.00	$0	0
2024-05-20	PAPADOPOULOS STELIOS	Dir	Open-market sell S	Common Stock	11,437	$21.00	$240,177	1,260,578
2024-05-20	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M	Common Stock	11,686	$19.57	$228,695	1,272,015
2024-05-15	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	39,681	$20.99	$832,904	964,384
2024-05-15	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	34,262	$20.99	$719,159	1,004,065
2024-05-13	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	11,686	$0.00	$0	0
2024-05-13	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	10,923	$21.37	$233,425	338,948
2024-05-13	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	11,686	$19.57	$228,695	349,871
2024-03-21	Garber Alan M	Dir	Exercise / conversion M · derivative	Option (right to buy)	23,491	$0.00	$0	0
2024-03-21	Garber Alan M	Dir	Open-market sell S	Common Stock	19,205	$24.01	$461,112	35,703
2024-03-21	Garber Alan M	Dir	Exercise / conversion M	Common Stock	23,491	$19.57	$459,719	54,908
2024-02-23	Peterson Amy C.	EVP Prod Dev & Med Aff & CMO	Equity grant / award A	Common Stock	82,121	$0.00	$0	322,121
2024-02-21	JOHNSON DAVID EDWARD	Dir	Open-market buy P	Common Stock	190,000	$20.70	$3,932,734	1,100,730
2024-02-15	Aftab Dana	CSO/EVP Disc & Trans Research	Other disposed transaction F	Common Stock	10,630	$20.39	$216,746	479,031
2024-01-11	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	63,717	$22.86	$1,456,571	796,657
2024-01-11	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	250,374	$0.00	$0	860,374
2024-01-05	Eckhardt Sue Gail	Dir	Equity grant / award A · derivative	Option (right to buy)	30,848	$0.00	$0	30,848
2024-01-05	Eckhardt Sue Gail	Dir	Equity grant / award A	Common Stock	15,424	$0.00	$0	15,424
2023-12-14	Haley Patrick J.	EVP, Commercial	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	0
2023-12-14	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	50,000	$23.35	$1,167,500	307,687
2023-12-14	Haley Patrick J.	EVP, Commercial	Exercise / conversion M	Common Stock	50,000	$16.29	$814,500	357,687
2023-12-13	Hessekiel Jeffrey	EVP, General Counsel & Sec	Open-market sell S	Common Stock	25,000	$23.01	$575,250	533,345
2023-12-12	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	14,149	$22.50	$318,352	307,687
2023-12-04	Hessekiel Jeffrey	EVP, General Counsel & Sec	Open-market sell S	Common Stock	25,000	$22.06	$551,500	558,345
2023-11-30	Hessekiel Jeffrey	EVP, General Counsel & Sec	Open-market sell S	Common Stock	25,000	$22.01	$550,250	583,345
2023-11-27	JOHNSON DAVID EDWARD	Dir	Open-market buy P	Common Stock	120,409	$21.61	$2,602,038	910,730
2023-11-27	JOHNSON DAVID EDWARD	Dir	Open-market sell S	Common Stock	120,409	$21.61	$2,602,038	790,321
2023-11-16	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	19,020	$0.00	$0	1,436,914
2023-11-07	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	116,893	$0.00	$0	1,455,934
2023-09-06	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	46,608	$22.27	$1,037,960	726,893
2023-09-06	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	188,005	$0.00	$0	773,501
2023-09-01	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	57,500	$0.00	$0	1,339,041
2023-08-31	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	56,221	$0.00	$0	1,396,541
2023-08-30	Aftab Dana	CSO/EVP Disc & Trans Research	Open-market sell S	Common Stock	4,600	$22.47	$103,362	399,943
2023-08-28	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	360,000	$0.00	$0	0
2023-08-28	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	303,779	$22.18	$6,737,818	641,717
2023-08-28	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	360,000	$15.31	$5,511,600	945,496
2023-08-24	Peterson Amy C.	EVP Prod Dev & Med Aff & CMO	Equity grant / award A · derivative	Option (right to buy)	160,000	$0.00	$0	160,000
2023-08-24	Peterson Amy C.	EVP Prod Dev & Med Aff & CMO	Equity grant / award A	Common Stock	240,000	$0.00	$0	240,000
2023-08-15	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	23,304	$21.51	$501,269	585,496
2023-08-04	Senner Christopher J.	EVP and CFO	Exercise / conversion M · derivative	Option (right to buy)	60,000	$0.00	$0	0
2023-08-04	Senner Christopher J.	EVP and CFO	Open-market sell S	Common Stock	60,000	$20.68	$1,240,800	571,631
2023-08-04	Senner Christopher J.	EVP and CFO	Exercise / conversion M	Common Stock	60,000	$14.74	$884,400	631,631
2023-08-03	Senner Christopher J.	EVP and CFO	Exercise / conversion M · derivative	Option (right to buy)	60,000	$0.00	$0	60,000
2023-08-03	Senner Christopher J.	EVP and CFO	Open-market sell S	Common Stock	60,000	$20.51	$1,230,600	571,631
2023-08-03	Senner Christopher J.	EVP and CFO	Exercise / conversion M	Common Stock	60,000	$14.74	$884,400	631,631
2023-08-01	Hessekiel Jeffrey	EVP, General Counsel & Sec	Exercise / conversion M · derivative	Option (right to buy)	55,710	$0.00	$0	0
2023-08-01	Hessekiel Jeffrey	EVP, General Counsel & Sec	Open-market sell S	Common Stock	55,710	$19.63	$1,093,587	571,976
2023-08-01	Hessekiel Jeffrey	EVP, General Counsel & Sec	Exercise / conversion M	Common Stock	55,710	$14.74	$821,165	627,686
2023-06-01	Garber Alan M	Dir	Equity grant / award A · derivative	Option (right to buy)	44,087	$0.00	$0	44,087
2023-05-31	Oliver Bob	Dir	Equity grant / award A · derivative	Option (right to buy)	36,353	$0.00	$0	36,353
2023-05-31	Oliver Bob	Dir	Equity grant / award A	Common Stock	18,176	$0.00	$0	18,176
2023-05-15	Hessekiel Jeffrey	EVP, General Counsel & Sec	Other disposed transaction F	Common Stock	7,027	$19.18	$134,778	571,976
2023-05-15	Hessekiel Jeffrey	EVP, General Counsel & Sec	Other disposed transaction F	Common Stock	4,940	$19.18	$94,749	579,003
2023-04-05	Hessekiel Jeffrey	EVP, General Counsel & Sec	Exercise / conversion M · derivative	Option (right to buy)	13,930	$0.00	$0	55,710
2023-04-05	Hessekiel Jeffrey	EVP, General Counsel & Sec	Open-market sell S	Common Stock	38,930	$20.01	$778,989	582,435
2023-04-05	Hessekiel Jeffrey	EVP, General Counsel & Sec	Exercise / conversion M	Common Stock	13,930	$14.74	$205,328	621,365
2023-04-03	Hessekiel Jeffrey	EVP, General Counsel & Sec	Equity grant / award A	Common Stock	79,719	$0.00	$0	607,435
2023-03-10	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2023-03-10	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	15,300	$16.61	$254,133	317,467
2023-03-10	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	40,000	$6.30	$252,000	332,767
2023-03-01	Hessekiel Jeffrey	EVP, General Counsel & Sec	Exercise / conversion M · derivative	Option (right to buy)	27,860	$0.00	$0	69,640
2023-03-01	Hessekiel Jeffrey	EVP, General Counsel & Sec	Open-market sell S	Common Stock	77,860	$17.13	$1,333,742	527,716
2023-03-01	Hessekiel Jeffrey	EVP, General Counsel & Sec	Exercise / conversion M	Common Stock	27,860	$14.74	$410,656	605,576
2023-02-28	Aftab Dana	CSO/EVP Disc & Trans Research	Exercise / conversion M · derivative	Option (right to buy)	82,490	$0.00	$0	0
2023-02-28	Aftab Dana	CSO/EVP Disc & Trans Research	Open-market sell S	Common Stock	82,490	$17.50	$1,443,575	351,472
2023-02-28	Aftab Dana	CSO/EVP Disc & Trans Research	Exercise / conversion M	Common Stock	82,490	$14.74	$1,215,903	433,962
2023-02-27	Aftab Dana	CSO/EVP Disc & Trans Research	Exercise / conversion M · derivative	Option (right to buy)	10	$0.00	$0	82,490
2023-02-27	Aftab Dana	CSO/EVP Disc & Trans Research	Open-market sell S	Common Stock	10	$17.50	$175	351,472
2023-02-27	Aftab Dana	CSO/EVP Disc & Trans Research	Exercise / conversion M	Common Stock	10	$14.74	$147	351,482
2023-02-21	Garber Alan M	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2023-02-21	Garber Alan M	Dir	Open-market sell S	Common Stock	40,000	$17.49	$699,600	31,417
2023-02-21	Garber Alan M	Dir	Exercise / conversion M	Common Stock	40,000	$6.30	$252,000	71,417
2023-02-15	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	11,522	$18.08	$208,318	329,133
2023-02-09	FELDBAUM CARL B	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2023-02-09	FELDBAUM CARL B	Dir	Open-market sell S	Common Stock	40,000	$17.78	$711,200	18,701
2023-02-09	FELDBAUM CARL B	Dir	Exercise / conversion M	Common Stock	40,000	$6.30	$252,000	58,701
2023-02-06	Haley Patrick J.	EVP, Commercial	Exercise / conversion M · derivative	Option (right to buy)	25,000	$0.00	$0	0
2023-02-06	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	25,000	$17.37	$434,250	254,414
2023-02-06	Haley Patrick J.	EVP, Commercial	Exercise / conversion M	Common Stock	25,000	$4.20	$105,000	279,414
2023-01-30	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	37,994	$0.00	$0	1,340,320
2023-01-24	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	0
2023-01-24	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	62,006	$17.36	$1,076,424	378,649
2023-01-24	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	100,000	$4.20	$420,000	440,655
2023-01-05	Aftab Dana	CSO/EVP Disc & Trans Research	Equity grant / award A	Common Stock	100,000	$0.00	$0	353,001
2022-12-15	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	20,000	$0.00	$0	20,000
2022-12-15	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	20,000	$15.88	$317,600	410,958
2022-12-15	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	20,000	$4.20	$84,000	430,958
2022-12-07	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	106,010	$0.00	$0	1,302,326
2022-11-29	POSTE GEORGE	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2022-11-29	POSTE GEORGE	Dir	Open-market sell S	Common Stock	40,000	$16.68	$667,200	193,189
2022-11-29	POSTE GEORGE	Dir	Exercise / conversion M	Common Stock	40,000	$6.30	$252,000	233,189
2022-11-15	Hessekiel Jeffrey	EVP, General Counsel & Sec	Other disposed transaction F	Common Stock	7,177	$16.71	$119,928	579,645
2022-11-15	Haley Patrick J.	EVP, Commercial	Other disposed transaction F	Common Stock	7,177	$16.71	$119,928	254,414
2022-09-12	Haley Patrick J.	EVP, Commercial	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2022-09-12	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	40,000	$17.94	$717,600	261,591
2022-09-12	Haley Patrick J.	EVP, Commercial	Exercise / conversion M	Common Stock	40,000	$6.21	$248,400	301,591
2022-08-11	Senner Christopher J.	EVP and CFO	Exercise / conversion M · derivative	Option (right to buy)	225,000	$0.00	$0	0
2022-08-11	Senner Christopher J.	EVP and CFO	Other disposed transaction F	Common Stock	152,867	$19.23	$2,939,632	518,015
2022-08-11	Senner Christopher J.	EVP and CFO	Exercise / conversion M	Common Stock	225,000	$6.21	$1,397,250	670,882
2022-08-03	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	23,304	$21.49	$500,803	469,969
2022-08-03	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	94,002	$0.00	$0	493,273
2022-05-27	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	18,812	$18.21	$342,567	239,818
2022-05-26	POSTE GEORGE	Dir	Equity grant / award A	Common Stock	19,575	$0.00	$0	193,189
2022-05-16	Hessekiel Jeffrey	EVP, General Counsel & Sec	Open-market sell S	Common Stock	18,000	$20.07	$361,260	586,822
2022-05-15	Haley Patrick J.	EVP, Commercial	Other disposed transaction F	Common Stock	7,384	$20.08	$148,271	258,630
2022-05-15	Haley Patrick J.	EVP, Commercial	Other disposed transaction F	Common Stock	4,339	$20.08	$87,127	266,014
2022-05-12	WILLSEY LANCE	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2022-05-12	WILLSEY LANCE	Dir	Open-market sell S	Common Stock	40,000	$19.65	$786,000	424,415
2022-05-12	WILLSEY LANCE	Dir	Exercise / conversion M	Common Stock	40,000	$3.13	$125,200	464,415
2022-04-04	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2022-04-04	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	6,696	$23.00	$154,008	273,192
2022-04-04	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	40,000	$3.13	$125,200	279,888
2022-04-01	Haley Patrick J.	EVP, Commercial	Exercise / conversion M · derivative	Option (right to buy)	10,000	$0.00	$0	40,000
2022-04-01	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	10,000	$23.00	$230,000	269,191
2022-04-01	Haley Patrick J.	EVP, Commercial	Exercise / conversion M	Common Stock	10,000	$6.21	$62,100	279,191
2022-03-31	Haley Patrick J.	EVP, Commercial	Exercise / conversion M · derivative	Option (right to buy)	10,000	$0.00	$0	50,000
2022-03-31	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	10,000	$22.43	$224,300	269,191
2022-03-31	Haley Patrick J.	EVP, Commercial	Exercise / conversion M	Common Stock	10,000	$6.21	$62,100	279,191
2022-03-29	Hessekiel Jeffrey	EVP, General Counsel & Sec	Open-market sell S	Common Stock	13,283	$22.00	$292,226	605,236
2022-03-28	Hessekiel Jeffrey	EVP, General Counsel & Sec	Open-market sell S	Common Stock	4,717	$22.00	$103,774	618,519
2022-03-04	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	270,415	$0.00	$0	399,271
2022-03-02	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	50,000	$0.00	$0	1,196,316
2022-03-01	Garber Alan M	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2022-03-01	Garber Alan M	Dir	Open-market sell S	Common Stock	21,301	$21.00	$447,321	31,417
2022-03-01	Garber Alan M	Dir	Exercise / conversion M	Common Stock	40,000	$3.13	$125,200	52,718
2022-02-25	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	31,238	$19.53	$610,078	198,476
2022-02-24	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	18,000	$20.00	$360,000	555,361
2022-02-22	PAPADOPOULOS STELIOS	Dir	Open-market sell S	Common Stock	84,515	$19.56	$1,653,113	1,220,036
2022-02-15	Lamb Peter	EVP, Scientific Strategy & CSO	Other disposed transaction F	Common Stock	17,651	$18.59	$328,132	342,995
2022-02-15	Lamb Peter	EVP, Scientific Strategy & CSO	Other disposed transaction F	Common Stock	2,526	$18.59	$46,958	360,646
2022-02-03	Haley Patrick J.	EVP, Commercial	Exercise / conversion M · derivative	Option (right to buy)	60,000	$0.00	$0	0
2022-02-03	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	60,000	$17.91	$1,074,600	245,241
2022-02-03	Haley Patrick J.	EVP, Commercial	Exercise / conversion M	Common Stock	60,000	$1.90	$114,000	305,241
2022-01-04	Goodman Vicki L	EVP, Prod Dev & Med Aff &CMO	Other disposed transaction F	Common Stock	7,613	$19.18	$146,017	242,387
2022-01-04	Goodman Vicki L	EVP, Prod Dev & Med Aff &CMO	Equity grant / award A	Common Stock	250,000	$0.00	$0	250,000
2021-12-16	Wright Jacqueline	Dir	Equity grant / award A · derivative	Option (right to buy)	41,717	$0.00	$0	41,717
2021-12-16	Wright Jacqueline	Dir	Equity grant / award A	Common Stock	20,858	$0.00	$0	20,858
2021-12-15	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	12,236	$17.00	$208,012	205,006
2021-12-15	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	46,478	$0.00	$0	217,242
2021-11-29	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	196,524	$0.00	$0	1,235,313
2021-11-24	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	17,236	$17.25	$297,321	237,802
2021-11-19	FELDBAUM CARL B	Dir	Exercise / conversion M · derivative	Option (right to buy)	20,000	$0.00	$0	20,000
2021-11-19	FELDBAUM CARL B	Dir	Open-market sell S	Common Stock	20,000	$17.62	$352,400	8,521
2021-11-19	FELDBAUM CARL B	Dir	Exercise / conversion M	Common Stock	20,000	$3.13	$62,600	28,521
2021-11-15	Haley Patrick J.	EVP, Commercial	Other disposed transaction F	Common Stock	44,184	$18.10	$799,730	255,038
2021-11-15	Haley Patrick J.	EVP, Commercial	Other disposed transaction F	Common Stock	983	$18.10	$17,792	299,222
2021-11-15	Haley Patrick J.	EVP, Commercial	Other disposed transaction F	Common Stock	4,323	$18.10	$78,246	300,205
2021-11-01	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	5,117	$22.03	$112,728	632,825
2021-10-22	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	24,747	$21.33	$527,854	561,068
2021-10-22	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	94,002	$0.00	$0	585,815
2021-10-15	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	47,500	$0.00	$0	95,000
2021-10-15	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	47,500	$21.92	$1,041,200	411,240
2021-10-15	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	47,500	$6.21	$294,975	458,740
2021-09-30	Senner Christopher J.	EVP and CFO	Other disposed transaction F	Common Stock	8,573	$20.63	$176,861	415,528
2021-09-30	Senner Christopher J.	EVP and CFO	Equity grant / award A	Common Stock	32,567	$0.00	$0	424,101
2021-09-21	Senner Christopher J.	EVP and CFO	Exercise / conversion M · derivative	Option (right to buy)	90,000	$0.00	$0	0
2021-09-21	Senner Christopher J.	EVP and CFO	Other disposed transaction F	Common Stock	55,057	$20.33	$1,119,309	391,534
2021-09-21	Senner Christopher J.	EVP and CFO	Exercise / conversion M	Common Stock	90,000	$3.66	$329,400	446,591
2021-09-16	Haley Patrick J.	EVP, Commercial	Exercise / conversion M · derivative	Option (right to buy)	25,000	$0.00	$0	0
2021-09-16	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	25,000	$20.36	$509,000	280,994
2021-09-16	Haley Patrick J.	EVP, Commercial	Exercise / conversion M	Common Stock	25,000	$1.70	$42,500	305,994
2021-09-15	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	47,500	$0.00	$0	142,500
2021-09-15	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	47,500	$20.46	$971,850	389,467
2021-09-15	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	47,500	$6.21	$294,975	436,967
2021-08-16	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	55,000	$0.00	$0	0
2021-08-16	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	55,000	$18.44	$1,014,200	389,467
2021-08-16	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	55,000	$1.90	$104,500	444,467
2021-07-26	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2021-07-26	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	40,000	$4.20	$168,000	689,078
2021-07-21	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	35,000	$0.00	$0	40,000
2021-07-21	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	35,000	$4.20	$147,000	649,078
2021-07-15	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	60,000	$0.00	$0	55,000
2021-07-15	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	60,000	$17.47	$1,048,200	389,467
2021-07-15	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	60,000	$1.90	$114,000	449,467
2021-07-06	COHEN CHARLES	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2021-07-06	COHEN CHARLES	Dir	Exercise / conversion M	Common Stock	40,000	$6.30	$252,000	261,375
2021-06-17	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	60,000	$0.00	$0	115,000
2021-06-17	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	60,000	$22.18	$1,330,800	389,467
2021-06-17	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	60,000	$1.90	$114,000	449,467
2021-05-27	WYSZOMIERSKI JACK L	Dir	Equity grant / award A · derivative	Option (right to buy)	16,598	$0.00	$0	16,598
2021-05-27	WYSZOMIERSKI JACK L	Dir	Equity grant / award A	Common Stock	8,299	$0.00	$0	239,888
2021-05-18	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	14,593	$24.73	$360,885	280,994
2021-05-17	Hessekiel Jeffrey	EVP, General Counsel & Sec	Open-market sell S	Common Stock	18,000	$25.39	$457,020	604,822
2021-05-15	Haley Patrick J.	EVP, Commercial	Other disposed transaction F	Common Stock	3,026	$25.56	$77,345	295,587
2021-05-14	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	19,722	$0.00	$0	1,038,789
2021-05-14	MARCHESI VINCENT T	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2021-05-14	MARCHESI VINCENT T	Dir	Open-market sell S	Common Stock	40,000	$25.04	$1,001,600	66,115
2021-05-14	MARCHESI VINCENT T	Dir	Exercise / conversion M	Common Stock	40,000	$6.30	$252,000	106,115
2021-05-13	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	150,000
2021-05-13	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	100,000	$25.38	$2,538,000	614,078
2021-05-13	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	100,000	$1.90	$190,000	714,078
2021-05-12	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	100,000
2021-05-12	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	30,278	$25.16	$761,794	511,535
2021-05-12	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	50,000	$4.20	$210,000	541,813
2021-05-11	Freire Maria C	Dir	Open-market sell S	Common Stock	8,275	$25.01	$206,958	31,827
2021-05-10	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	40,616	$0.00	$0	1,019,067
2021-04-26	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	0
2021-04-26	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	50,000	$25.00	$1,250,000	613,482
2021-04-26	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	50,000	$1.70	$85,000	663,482
2021-04-01	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	60,000	$0.00	$0	0
2021-04-01	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	60,000	$22.96	$1,377,600	389,467
2021-04-01	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	60,000	$1.70	$102,000	449,467
2021-03-29	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2021-03-29	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	6,220	$22.64	$140,821	231,589
2021-03-29	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	40,000	$3.38	$135,200	237,809
2021-03-15	Garber Alan M	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2021-03-15	Garber Alan M	Dir	Open-market sell S	Common Stock	40,000	$23.60	$944,000	12,718
2021-03-15	Garber Alan M	Dir	Exercise / conversion M	Common Stock	40,000	$3.38	$135,200	52,718
2021-03-04	MORRISSEY MICHAEL	President and CEO	Equity grant / award A · derivative	Option (right to buy)	494,700	$0.00	$0	494,700
2021-03-04	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Equity grant / award A	Common Stock	72,885	$0.00	$0	613,482
2021-03-01	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	65,000	$0.00	$0	60,000
2021-03-01	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	65,000	$22.11	$1,437,150	340,072
2021-03-01	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	65,000	$1.70	$110,500	405,072
2021-02-24	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	67,374	$0.00	$0	1,059,683
2021-02-23	WILLSEY LANCE	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2021-02-23	WILLSEY LANCE	Dir	Open-market sell S	Common Stock	800	$22.34	$17,872	424,415
2021-02-23	WILLSEY LANCE	Dir	Open-market sell S	Common Stock	39,200	$21.92	$859,264	425,215
2021-02-23	WILLSEY LANCE	Dir	Exercise / conversion M	Common Stock	40,000	$3.38	$135,200	464,415
2021-02-22	POSTE GEORGE	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2021-02-22	POSTE GEORGE	Dir	Exercise / conversion M	Common Stock	40,000	$3.38	$135,200	197,992
2021-02-18	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	100,000
2021-02-18	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	50,000	$22.35	$1,117,500	540,597
2021-02-18	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	50,000	$1.70	$85,000	590,597
2021-02-17	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	150,000
2021-02-17	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	50,000	$22.50	$1,125,000	540,597
2021-02-17	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	50,000	$1.70	$85,000	590,597
2021-02-16	WILLSEY LANCE	Dir	Open-market sell S	Common Stock	50,000	$21.90	$1,095,000	424,415
2021-02-15	Haley Patrick J.	EVP, Commercial	Other disposed transaction F	Common Stock	1,400	$21.91	$30,674	245,487
2021-02-15	Senner Christopher J.	EVP and CFO	Other disposed transaction F	Common Stock	4,105	$21.91	$89,941	292,441
2021-02-12	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	45,000	$21.57	$970,650	246,887
2021-02-03	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	65,190	$22.56	$1,470,686	568,976
2021-02-03	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	23,238	$0.00	$0	409,879
2021-02-01	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	65,000	$0.00	$0	125,000
2021-02-01	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	65,000	$22.08	$1,435,200	283,124
2021-02-01	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	65,000	$1.70	$110,500	348,124
2021-01-12	Senner Christopher J.	EVP and CFO	Exercise / conversion M · derivative	Option (right to buy)	30,000	$0.00	$0	90,000
2021-01-12	Senner Christopher J.	EVP and CFO	Open-market sell S	Common Stock	30,000	$25.00	$750,000	245,596
2021-01-12	Senner Christopher J.	EVP and CFO	Exercise / conversion M	Common Stock	30,000	$3.66	$109,800	275,596
2021-01-04	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	65,000	$0.00	$0	190,000
2021-01-04	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	65,000	$20.32	$1,320,800	283,124
2021-01-04	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	65,000	$1.70	$110,500	348,124
2020-12-28	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	126,565	$0.00	$0	992,309
2020-12-18	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	65,000	$0.00	$0	255,000
2020-12-18	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	65,000	$20.01	$1,300,650	283,124
2020-12-18	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	65,000	$1.70	$110,500	348,124
2020-12-04	WILLSEY LANCE	Dir	Exercise / conversion M · derivative	Option (right to buy)	106,142	$0.00	$0	0
2020-12-04	WILLSEY LANCE	Dir	Exercise / conversion M	Common Stock	106,142	$5.82	$617,746	474,415
2020-11-24	MARCHESI VINCENT T	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,004	$0.00	$0	0
2020-11-24	MARCHESI VINCENT T	Dir	Open-market sell S	Common Stock	40,004	$18.50	$740,074	90,212
2020-11-24	MARCHESI VINCENT T	Dir	Exercise / conversion M	Common Stock	40,004	$5.82	$232,823	130,216
2020-11-20	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	187,239	$0.00	$0	1,118,874
2020-11-15	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	7,898	$20.16	$159,224	573,880
2020-11-15	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	10,530	$20.16	$212,285	581,778
2020-11-15	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	6,526	$20.16	$131,564	592,308
2020-11-10	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	62,403	$0.00	$0	0
2020-11-10	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	34,000	$20.61	$700,740	197,809
2020-11-10	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	62,403	$5.82	$363,185	231,809
2020-10-22	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	177,132	$21.79	$3,859,706	598,834
2020-10-22	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	672,861	$0.00	$0	775,966
2020-10-21	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	39,742	$0.00	$0	60,000
2020-10-21	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	39,742	$21.95	$872,337	343,026
2020-10-21	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	39,742	$7.27	$288,924	382,768
2020-10-08	Senner Christopher J.	EVP and CFO	Exercise / conversion M · derivative	Option (right to buy)	10,000	$0.00	$0	120,000
2020-10-08	Senner Christopher J.	EVP and CFO	Open-market sell S	Common Stock	10,000	$25.00	$250,000	127,882
2020-10-08	Senner Christopher J.	EVP and CFO	Exercise / conversion M	Common Stock	10,000	$3.66	$36,600	137,882
2020-09-22	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	10,258	$0.00	$0	99,742
2020-09-22	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	10,258	$26.14	$268,144	343,026
2020-09-22	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	10,258	$7.27	$74,576	353,284
2020-09-21	Haley Patrick J.	EVP, Commercial	Exercise / conversion M · derivative	Option (right to buy)	4,680	$0.00	$0	0
2020-09-21	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	4,680	$26.09	$122,101	115,571
2020-09-21	Haley Patrick J.	EVP, Commercial	Exercise / conversion M	Common Stock	4,680	$5.82	$27,238	120,251
2020-09-18	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	32,500	$0.00	$0	931,635
2020-09-17	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	25,000	$0.00	$0	964,135
2020-09-16	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	20,000	$0.00	$0	110,000
2020-09-16	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	20,000	$26.11	$522,200	343,026
2020-09-16	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	20,000	$7.27	$145,400	363,026
2020-09-16	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	42,500	$0.00	$0	989,135
2020-09-15	Senner Christopher J.	EVP and CFO	Exercise / conversion M · derivative	Option (right to buy)	20,000	$0.00	$0	130,000
2020-09-15	Senner Christopher J.	EVP and CFO	Open-market sell S	Common Stock	20,000	$25.00	$500,000	127,882
2020-09-15	Senner Christopher J.	EVP and CFO	Exercise / conversion M	Common Stock	20,000	$3.66	$73,200	147,882
2020-09-08	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	190,000	$0.00	$0	0
2020-09-08	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	59,692	$0.00	$0	20,000
2020-09-08	Hessekiel Jeffrey	EVP and General Counsel	Other disposed transaction F	Common Stock	160,666	$20.71	$3,327,393	343,026
2020-09-08	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	190,000	$6.21	$1,179,900	503,692
2020-09-08	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	59,692	$1.90	$113,415	313,692
2020-09-02	Lamb Peter	EVP, Scientific Strategy & CSO	Other disposed transaction F	Common Stock	2,323	$21.58	$50,130	133,578
2020-09-02	Lamb Peter	EVP, Scientific Strategy & CSO	Equity grant / award A	Common Stock	9,370	$0.00	$0	135,901
2020-09-01	COHEN CHARLES	Dir	Exercise / conversion M · derivative	Option (right to buy)	115,396	$0.00	$0	0
2020-09-01	COHEN CHARLES	Dir	Exercise / conversion M	Common Stock	115,396	$5.82	$671,605	181,375
2020-08-14	POSTE GEORGE	Dir	Exercise / conversion M · derivative	Option (right to buy)	29,662	$0.00	$0	0
2020-08-14	POSTE GEORGE	Dir	Exercise / conversion M	Common Stock	29,662	$5.82	$172,633	157,992
2020-07-22	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	35,863	$0.00	$0	1,031,635
2020-07-20	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	0
2020-07-20	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	64,137	$25.60	$1,641,907	121,848
2020-07-20	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	100,000	$6.21	$621,000	185,985
2020-07-14	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	35,559	$0.00	$0	995,772
2020-07-10	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	100,000
2020-07-10	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	64,441	$24.94	$1,607,159	121,544
2020-07-10	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	100,000	$6.21	$621,000	185,985
2020-06-24	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	35,189	$0.00	$0	960,213
2020-06-19	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	200,000
2020-06-19	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	64,811	$24.18	$1,567,130	121,174
2020-06-19	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	100,000	$6.21	$621,000	185,985
2020-06-08	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	26,000	$0.00	$0	0
2020-06-08	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	26,000	$22.56	$586,560	126,531
2020-06-08	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	26,000	$5.51	$143,260	152,531
2020-06-04	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	200,000
2020-06-04	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	100,000	$22.96	$2,296,000	325,963
2020-06-04	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	100,000	$1.70	$170,000	425,963
2020-06-02	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	35,450	$0.00	$0	925,024
2020-05-29	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	300,000
2020-05-29	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	64,550	$24.71	$1,595,030	121,435
2020-05-29	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	100,000	$6.21	$621,000	185,985
2020-05-21	MARCHESI VINCENT T	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	40,004
2020-05-21	MARCHESI VINCENT T	Dir	Equity grant / award A · derivative	Option (right to buy)	15,456	$0.00	$0	15,456
2020-05-21	MARCHESI VINCENT T	Dir	Open-market sell S	Common Stock	40,000	$24.64	$985,600	90,212
2020-05-21	MARCHESI VINCENT T	Dir	Exercise / conversion M	Common Stock	40,000	$5.82	$232,800	130,212
2020-05-21	MARCHESI VINCENT T	Dir	Equity grant / award A	Common Stock	7,728	$0.00	$0	90,212
2020-05-20	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	3,151	$24.99	$78,743	115,340
2020-05-19	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	35,935	$0.00	$0	889,574
2020-05-18	WILLSEY LANCE	Dir	Exercise / conversion M · derivative	Option (right to buy)	30,000	$0.00	$0	0
2020-05-18	WILLSEY LANCE	Dir	Open-market sell S	Common Stock	30,000	$26.26	$787,800	368,273
2020-05-18	WILLSEY LANCE	Dir	Exercise / conversion M	Common Stock	30,000	$4.58	$137,400	398,273
2020-05-15	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	400,000
2020-05-15	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	64,065	$25.76	$1,650,314	121,920
2020-05-15	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	100,000	$6.21	$621,000	185,985
2020-05-14	WILLSEY LANCE	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2020-05-14	WILLSEY LANCE	Dir	Open-market sell S	Common Stock	15,000	$25.26	$378,900	368,273
2020-05-14	WILLSEY LANCE	Dir	Exercise / conversion M	Common Stock	15,000	$5.92	$88,800	383,273
2020-05-13	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	25,000	$0.00	$0	0
2020-05-13	Hessekiel Jeffrey	EVP and General Counsel	Other disposed transaction F	Common Stock	13,875	$26.53	$368,104	250,313
2020-05-13	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	25,000	$1.70	$42,500	264,188
2020-05-11	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	38,006	$0.00	$0	79,692
2020-05-11	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	38,006	$27.09	$1,029,583	239,188
2020-05-11	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	38,006	$1.90	$72,211	277,194
2020-05-11	MARCHESI VINCENT T	Dir	Exercise / conversion M · derivative	Option (right to buy)	30,000	$0.00	$0	0
2020-05-11	MARCHESI VINCENT T	Dir	Open-market sell S	Common Stock	30,000	$26.30	$789,000	82,484
2020-05-11	MARCHESI VINCENT T	Dir	Exercise / conversion M	Common Stock	30,000	$4.58	$137,400	112,484
2020-05-08	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	126,313	$0.00	$0	853,639
2020-05-08	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	25,000	$0.00	$0	117,698
2020-05-08	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	25,000	$26.04	$651,000	239,188
2020-05-08	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	25,000	$1.90	$47,500	264,188
2020-05-08	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2020-05-08	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M · derivative	Option (right to buy)	30,000	$0.00	$0	0
2020-05-08	PAPADOPOULOS STELIOS	Dir	Open-market sell S	Common Stock	45,000	$25.84	$1,162,800	1,052,568
2020-05-08	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M	Common Stock	15,000	$5.92	$88,800	1,097,568
2020-05-08	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M	Common Stock	30,000	$4.58	$137,400	1,082,568
2020-05-07	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	30,000	$0.00	$0	142,698
2020-05-07	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	30,000	$25.61	$768,300	239,188
2020-05-07	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	30,000	$1.90	$57,000	269,188
2020-05-06	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	285,284	$0.00	$0	0
2020-05-06	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	158,971	$26.19	$4,163,450	212,298
2020-05-06	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	285,284	$1.70	$484,983	371,269
2020-04-29	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	126,565	$0.00	$0	727,326
2020-04-27	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	285,000	$0.00	$0	285,284
2020-04-27	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	158,435	$27.37	$4,336,366	212,550
2020-04-27	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	285,000	$1.70	$484,500	370,985
2020-04-27	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	93,640	$0.00	$0	600,761
2020-04-23	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	250,000	$0.00	$0	0
2020-04-23	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	156,360	$26.37	$4,123,213	179,625
2020-04-23	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	250,000	$5.51	$1,377,500	335,985
2020-04-23	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	80,799	$0.00	$0	507,121
2020-04-22	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	87,079	$0.00	$0	426,322
2020-04-21	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	220,000	$0.00	$0	250,000
2020-04-21	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	139,201	$24.56	$3,418,777	253,863
2020-04-21	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	220,000	$5.51	$1,212,200	393,064
2020-04-20	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	240,000	$0.00	$0	0
2020-04-20	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	152,921	$23.58	$3,605,877	173,064
2020-04-20	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	240,000	$5.51	$1,322,400	325,985
2020-04-15	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	25,000	$18.31	$457,750	913,031
2020-04-08	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	7,065	$18.35	$129,643	938,031
2020-04-07	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	16,435	$18.25	$299,939	945,096
2020-04-06	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	76,000
2020-04-06	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	50,000	$17.26	$863,000	126,531
2020-04-06	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	50,000	$5.51	$275,500	176,531
2020-04-03	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	30,000	$0.00	$0	0
2020-04-03	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2020-04-03	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	13,848	$16.57	$229,461	161,678
2020-04-03	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	30,000	$4.58	$137,400	175,526
2020-04-03	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	15,000	$5.92	$88,800	145,526
2020-03-31	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	1,500	$18.06	$27,090	961,531
2020-03-20	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	4,318	$15.37	$66,368	116,873
2020-03-09	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	17,116	$0.00	$0	339,243
2020-03-04	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	470,000
2020-03-04	MORRISSEY MICHAEL	President and CEO	Other disposed transaction F	Common Stock	32,884	$19.89	$654,063	103,101
2020-03-04	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	50,000	$5.51	$275,500	135,985
2020-03-03	FELDBAUM CARL B	Dir	Exercise / conversion M · derivative	Option (right to buy)	6,000	$0.00	$0	0
2020-03-03	FELDBAUM CARL B	Dir	Exercise / conversion M · derivative	Option (right to buy)	32,000	$0.00	$0	11,546
2020-03-03	FELDBAUM CARL B	Dir	Open-market sell S	Common Stock	653	$18.41	$12,022	8,521
2020-03-03	FELDBAUM CARL B	Dir	Open-market sell S	Common Stock	37,347	$18.85	$703,991	9,174
2020-03-03	FELDBAUM CARL B	Dir	Exercise / conversion M	Common Stock	6,000	$4.58	$27,480	46,521
2020-03-03	FELDBAUM CARL B	Dir	Exercise / conversion M	Common Stock	32,000	$5.82	$186,240	40,521
2020-02-28	COHEN CHARLES	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2020-02-28	COHEN CHARLES	Dir	Exercise / conversion M · derivative	Option (right to buy)	30,000	$0.00	$0	0
2020-02-28	COHEN CHARLES	Dir	Exercise / conversion M	Common Stock	15,000	$5.92	$88,800	65,979
2020-02-28	COHEN CHARLES	Dir	Exercise / conversion M	Common Stock	30,000	$4.58	$137,400	50,979
2020-02-26	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	25,000	$0.00	$0	520,000
2020-02-26	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	500	$19.60	$9,800	85,985
2020-02-26	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	24,500	$18.90	$463,050	86,485
2020-02-26	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	25,000	$5.51	$137,750	110,985
2020-02-19	Haley Patrick J.	EVP, Commercial	Exercise / conversion M · derivative	Option (right to buy)	5,000	$0.00	$0	35,000
2020-02-19	Haley Patrick J.	EVP, Commercial	Open-market sell S	Common Stock	5,000	$22.00	$110,000	121,191
2020-02-19	Haley Patrick J.	EVP, Commercial	Exercise / conversion M	Common Stock	5,000	$0.00	$0	126,191
2020-02-19	Haley Patrick J.	EVP, Commercial	Equity grant / award A	Common Stock	35,000	$0.00	$0	121,191
2020-02-18	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	50,000	$20.73	$1,036,500	963,031
2020-02-14	Garber Alan M	Dir	Open-market sell S	Common Stock	12,500	$21.02	$262,750	48,829
2020-02-13	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	25,000	$20.11	$502,750	85,985
2020-02-13	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	25,000	$0.00	$0	570,000
2020-02-12	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	21,000	$20.02	$420,420	1,013,031
2020-02-11	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	4,000	$20.14	$80,560	1,034,031
2020-02-07	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	40,000
2020-02-07	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	50,000	$18.37	$918,500	325,122
2020-02-07	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	50,000	$5.51	$275,500	375,122
2020-02-03	MORRISSEY MICHAEL	President and CEO	Equity grant / award A	Common Stock	224,287	$0.00	$0	634,166
2020-01-29	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	25,000	$17.87	$446,750	85,985
2020-01-29	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	25,000	$0.00	$0	595,000
2020-01-23	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	25,000	$19.41	$485,250	85,985
2020-01-23	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	25,000	$0.00	$0	620,000
2020-01-22	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	25,000	$19.75	$493,750	1,038,031
2020-01-16	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	25,000	$20.33	$508,250	85,985
2020-01-16	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	25,000	$0.00	$0	645,000
2020-01-15	MARCHESI VINCENT T	Dir	Open-market sell S	Common Stock	61,683	$20.01	$1,234,277	82,484
2020-01-08	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	25,000	$18.85	$471,250	85,985
2020-01-08	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	25,000	$0.00	$0	670,000
2020-01-07	Garber Alan M	Dir	Exercise / conversion M · derivative	Option (right to buy)	56,956	$0.00	$0	0
2020-01-07	Garber Alan M	Dir	Exercise / conversion M · derivative	Option (right to buy)	30,000	$0.00	$0	0
2020-01-07	Garber Alan M	Dir	Open-market sell S	Common Stock	86,956	$18.01	$1,566,078	61,329
2020-01-07	Garber Alan M	Dir	Exercise / conversion M	Common Stock	56,956	$5.82	$331,484	148,285
2020-01-07	Garber Alan M	Dir	Exercise / conversion M	Common Stock	30,000	$4.58	$137,400	91,329
2020-01-02	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	25,000	$17.49	$437,250	85,985
2020-01-02	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	25,000	$0.00	$0	695,000
2019-12-27	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	25,000	$18.25	$456,250	1,090,531
2019-12-13	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	128,129	$0.00	$0	322,127
2019-12-12	SCANGOS GEORGE A	Dir	Equity grant / award G	Common Stock	12,500	$0.00	$0	1,115,531
2019-12-04	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Other disposed transaction F	Common Stock	4,027	$17.67	$71,157	325,122
2019-12-04	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Equity grant / award A	Common Stock	15,592	$0.00	$0	329,149
2019-12-03	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	140,000
2019-12-03	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	50,000	$16.22	$811,000	313,557
2019-12-03	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	50,000	$5.51	$275,500	363,557
2019-11-15	Hessekiel Jeffrey	EVP and General Counsel	Other disposed transaction F	Common Stock	2,131	$16.51	$35,183	230,934
2019-11-15	Hessekiel Jeffrey	EVP and General Counsel	Other disposed transaction F	Common Stock	6,557	$16.51	$108,256	233,065
2019-11-04	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$5.51	$275,500	190,000
2019-11-04	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	50,000	$15.99	$799,500	324,331
2019-11-04	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	50,000	$5.51	$275,500	374,331
2019-10-10	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	303	$16.27	$4,930	89,209
2019-10-02	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	35,409	$0.00	$0	0
2019-10-02	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	26,364	$17.66	$465,588	205,149
2019-10-02	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	35,409	$7.18	$254,237	231,513
2019-10-01	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	30,000	$5.51	$165,300	0
2019-10-01	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	30,000	$17.87	$536,100	324,331
2019-10-01	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	30,000	$5.51	$165,300	354,331
2019-09-18	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	35,409
2019-09-18	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	37,227	$19.20	$714,758	196,104
2019-09-18	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	50,000	$7.18	$359,000	233,331
2019-09-12	Hessekiel Jeffrey	EVP and General Counsel	Other disposed transaction F	Common Stock	1,487	$19.26	$28,640	238,330
2019-09-12	Hessekiel Jeffrey	EVP and General Counsel	Equity grant / award A	Common Stock	5,997	$0.00	$0	239,817
2019-09-10	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	1,000	$18.84	$18,840	85,453
2019-08-16	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	75,000	$0.00	$0	25,000
2019-08-16	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	75,000	$21.10	$1,582,500	233,820
2019-08-16	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	75,000	$1.70	$127,500	308,820
2019-08-14	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$7.18	$359,000	85,409
2019-08-14	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	35,040	$20.11	$704,654	165,069
2019-08-14	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	50,000	$7.18	$359,000	200,109
2019-08-12	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	1,000	$20.39	$20,390	86,453
2019-08-09	POSTE GEORGE	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2019-08-09	POSTE GEORGE	Dir	Exercise / conversion M · derivative	Option (right to buy)	5,000	$0.00	$0	25,000
2019-08-09	POSTE GEORGE	Dir	Open-market sell S	Common Stock	20,000	$20.60	$412,000	112,792
2019-08-09	POSTE GEORGE	Dir	Exercise / conversion M	Common Stock	15,000	$5.92	$88,800	132,792
2019-08-09	POSTE GEORGE	Dir	Exercise / conversion M	Common Stock	5,000	$4.58	$22,900	117,792
2019-08-06	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M · derivative	Option (right to buy)	25,000	$0.00	$0	40,000
2019-08-06	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	25,000	$20.02	$500,500	87,453
2019-08-06	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M	Common Stock	25,000	$1.70	$42,500	112,453
2019-08-02	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$7.18	$359,000	135,409
2019-08-02	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	35,040	$20.25	$709,560	150,109
2019-08-02	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	50,000	$7.18	$359,000	185,149
2019-08-01	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	6,050	$21.23	$128,442	1,128,031
2019-08-01	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	33,950	$20.48	$695,296	1,134,081
2019-07-17	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	185,409
2019-07-17	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	34,721	$21.37	$741,988	135,149
2019-07-17	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	50,000	$7.18	$359,000	169,870
2019-07-10	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	1,000	$20.96	$20,960	87,453
2019-07-03	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	235,409
2019-07-03	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	34,721	$21.03	$730,183	119,870
2019-07-03	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	50,000	$7.18	$359,000	154,591
2019-07-01	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	40,000	$21.58	$863,200	1,168,031
2019-06-19	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	17,404	$0.00	$0	0
2019-06-19	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	17,404	$5.51	$95,896	134,601
2019-06-18	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	24,596	$0.00	$0	17,404
2019-06-18	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	75,404	$0.00	$0	320,000
2019-06-18	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	100,000	$20.67	$2,067,000	117,197
2019-06-18	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	24,596	$5.51	$135,524	217,197
2019-06-18	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	75,404	$1.70	$128,187	192,601
2019-06-17	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	4,596	$0.00	$0	395,404
2019-06-17	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	95,404	$0.00	$0	0
2019-06-17	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	17,404	$20.76	$361,307	117,197
2019-06-17	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	100,000	$20.49	$2,049,000	117,197
2019-06-17	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	4,596	$1.70	$7,813	217,197
2019-06-17	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	95,404	$5.56	$530,446	212,601
2019-06-13	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M · derivative	Option (right to buy)	27,596	$0.00	$0	95,404
2019-06-13	Lamb Peter	EVP, Scientific Strategy & CSO	Open-market sell S	Common Stock	27,596	$20.03	$552,748	117,197
2019-06-13	Lamb Peter	EVP, Scientific Strategy & CSO	Exercise / conversion M	Common Stock	27,596	$5.56	$153,434	144,793
2019-06-10	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	1,000	$20.23	$20,230	88,453
2019-06-04	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	15,000	$20.00	$300,000	1,208,031
2019-06-03	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	25,000	$19.61	$490,250	1,223,031
2019-05-29	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	14,591	$0.00	$0	285,409
2019-05-29	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	14,591	$7.18	$104,763	104,591
2019-05-23	Smith Julie	Dir	Equity grant / award A · derivative	Option (right to buy)	42,641	$0.00	$0	42,641
2019-05-21	SCANGOS GEORGE A	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2019-05-21	SCANGOS GEORGE A	Dir	Exercise / conversion M	Common Stock	15,000	$4.57	$68,550	1,248,031
2019-05-10	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	1,000	$19.58	$19,580	89,453
2019-05-08	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	42,000	$0.00	$0	0
2019-05-08	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	42,000	$20.15	$846,300	90,000
2019-05-08	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	42,000	$5.56	$233,520	132,000
2019-05-03	Senner Christopher J.	EVP and CFO	Open-market sell S	Common Stock	36,261	$20.70	$750,603	112,362
2019-05-02	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	15,000	$20.00	$300,000	1,233,031
2019-05-01	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	25,000	$19.75	$493,750	1,248,031
2019-04-24	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	42,000
2019-04-24	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	40,000	$20.75	$830,000	90,000
2019-04-24	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	40,000	$5.56	$222,400	130,000
2019-04-10	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	1,000	$24.04	$24,040	88,780
2019-04-03	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	63,109	$7.18	$453,123	0
2019-04-03	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	63,109	$25.00	$1,577,725	316,513
2019-04-03	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	63,109	$7.18	$453,123	379,622
2019-04-01	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2019-04-01	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	11,250	$0.00	$0	0
2019-04-01	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	7,822	$23.97	$187,493	120,209
2019-04-01	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	15,000	$4.57	$68,550	128,031
2019-04-01	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	11,250	$4.16	$46,800	113,031
2019-03-29	POSTE GEORGE	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2019-03-29	POSTE GEORGE	Dir	Open-market sell S	Common Stock	3,860	$23.89	$92,215	102,475
2019-03-29	POSTE GEORGE	Dir	Exercise / conversion M	Common Stock	15,000	$4.57	$68,550	106,335
2019-03-27	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	122,000
2019-03-27	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	40,000	$23.39	$935,600	90,000
2019-03-27	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	40,000	$5.56	$222,400	130,000
2019-03-26	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M · derivative	Option (right to buy)	2,700	$0.00	$0	0
2019-03-26	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	2,700	$23.47	$63,369	89,780
2019-03-26	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M	Common Stock	2,700	$5.18	$13,986	92,480
2019-03-25	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	63,109
2019-03-25	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	100,000	$23.14	$2,314,000	316,513
2019-03-25	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	100,000	$7.18	$718,000	416,513
2019-03-14	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	5,000	$25.00	$125,000	1,318,031
2019-03-13	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	162,000
2019-03-13	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	28,367	$24.80	$703,502	90,000
2019-03-13	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	11,633	$24.24	$281,984	118,367
2019-03-13	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	40,000	$5.56	$222,400	130,000
2019-03-11	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	959	$23.13	$22,182	89,780
2019-03-01	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	40,000	$22.66	$906,400	1,323,031
2019-02-27	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	202,000
2019-02-27	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	40,000	$22.69	$907,600	90,000
2019-02-27	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	40,000	$5.56	$222,400	130,000
2019-02-25	COHEN CHARLES	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2019-02-25	COHEN CHARLES	Dir	Exercise / conversion M · derivative	Option (right to buy)	11,250	$0.00	$0	0
2019-02-25	COHEN CHARLES	Dir	Open-market sell S	Common Stock	5,271	$22.18	$116,911	20,979
2019-02-25	COHEN CHARLES	Dir	Exercise / conversion M	Common Stock	15,000	$4.57	$68,550	26,250
2019-02-25	COHEN CHARLES	Dir	Exercise / conversion M	Common Stock	11,250	$4.16	$46,800	11,250
2019-02-22	MARCHESI VINCENT T	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2019-02-22	MARCHESI VINCENT T	Dir	Exercise / conversion M · derivative	Option (right to buy)	11,250	$0.00	$0	0
2019-02-22	MARCHESI VINCENT T	Dir	Open-market sell S	Common Stock	41,250	$21.50	$886,875	133,850
2019-02-22	MARCHESI VINCENT T	Dir	Exercise / conversion M	Common Stock	15,000	$4.57	$68,550	175,100
2019-02-22	MARCHESI VINCENT T	Dir	Exercise / conversion M	Common Stock	11,250	$4.16	$46,800	145,100
2019-02-21	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2019-02-21	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M · derivative	Option (right to buy)	11,250	$0.00	$0	0
2019-02-21	PAPADOPOULOS STELIOS	Dir	Open-market sell S	Common Stock	26,250	$21.25	$557,812	1,042,251
2019-02-21	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M	Common Stock	15,000	$4.57	$68,550	1,068,501
2019-02-21	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M	Common Stock	11,250	$4.16	$46,800	1,053,501
2019-02-20	WILLSEY LANCE	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2019-02-20	WILLSEY LANCE	Dir	Exercise / conversion M · derivative	Option (right to buy)	11,250	$0.00	$0	0
2019-02-20	WILLSEY LANCE	Dir	Open-market sell S	Common Stock	26,250	$21.11	$554,138	418,273
2019-02-20	WILLSEY LANCE	Dir	Exercise / conversion M	Common Stock	15,000	$4.57	$68,550	444,523
2019-02-20	WILLSEY LANCE	Dir	Exercise / conversion M	Common Stock	11,250	$4.16	$46,800	429,523
2019-02-19	COHEN CHARLES	Dir	Open-market sell S	Common Stock	48,180	$21.48	$1,034,906	0
2019-02-15	COHEN CHARLES	Dir	Open-market sell S	Common Stock	100,000	$22.19	$2,219,000	48,180
2019-02-14	COHEN CHARLES	Dir	Open-market sell S	Common Stock	100,000	$22.41	$2,241,000	148,180
2019-02-11	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	1,000	$21.30	$21,300	95,011
2019-02-01	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	40,000	$23.53	$941,200	1,363,031
2019-01-30	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	40,000	$23.12	$924,800	90,000
2019-01-30	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	40,000	$0.00	$0	282,000
2019-01-16	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	400	$0.00	$0	322,000
2019-01-16	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	39,600	$0.00	$0	322,400
2019-01-16	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	400	$23.92	$9,568	90,000
2019-01-16	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	39,600	$23.28	$921,888	90,400
2019-01-16	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	40,000	$5.56	$222,400	130,000
2019-01-10	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M · derivative	Option (right to buy)	2,000	$0.00	$0	23,375
2019-01-10	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	1,000	$23.54	$23,540	96,011
2019-01-10	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	2,000	$24.00	$48,000	97,011
2019-01-10	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M	Common Stock	2,000	$1.76	$3,520	99,011
2019-01-09	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M · derivative	Option (right to buy)	1,560	$0.00	$0	4,680
2019-01-09	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	1,560	$23.50	$36,660	97,011
2019-01-09	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M	Common Stock	1,560	$5.82	$9,079	98,571
2019-01-08	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M · derivative	Option (right to buy)	2,000	$0.00	$0	25,375
2019-01-08	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	2,000	$23.00	$46,000	97,011
2019-01-08	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M	Common Stock	2,000	$1.76	$3,520	99,011
2019-01-08	Garber Alan M	Dir	Exercise / conversion M · derivative	Option (right to buy)	11,250	$0.00	$0	0
2019-01-08	Garber Alan M	Dir	Open-market sell S	Common Stock	11,250	$23.00	$258,750	61,329
2019-01-08	Garber Alan M	Dir	Exercise / conversion M	Common Stock	11,250	$4.16	$46,800	72,579
2019-01-07	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M · derivative	Option (right to buy)	4,000	$0.00	$0	27,375
2019-01-07	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M · derivative	Option (right to buy)	1,560	$0.00	$0	6,240
2019-01-07	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	4,000	$21.52	$86,080	97,011
2019-01-07	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M	Common Stock	4,000	$1.76	$7,040	101,011
2019-01-07	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	1,560	$21.50	$33,540	97,011
2019-01-07	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M	Common Stock	1,560	$5.82	$9,079	98,571
2019-01-04	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	30,383	$20.14	$611,914	90,000
2019-01-04	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	30,383	$0.00	$0	362,000
2019-01-03	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	3,571	$20.00	$71,420	90,000
2019-01-03	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	3,571	$0.00	$0	392,383
2019-01-03	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M · derivative	Option (right to buy)	8,000	$0.00	$0	31,375
2019-01-03	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	8,000	$19.95	$159,600	97,011
2019-01-03	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M	Common Stock	8,000	$1.76	$14,080	105,011
2019-01-02	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	6,046	$20.00	$120,920	90,000
2019-01-02	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Common Stock	6,046	$0.00	$0	395,954
2018-12-03	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	40,000	$21.16	$846,400	1,456,981
2018-12-03	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	13,499	$0.00	$0	0
2018-12-03	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	13,499	$21.02	$283,749	316,513
2018-12-03	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	13,499	$5.04	$68,035	330,012
2018-11-30	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	1,943	$19.91	$38,685	233,820
2018-11-30	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	8,500	$20.00	$170,000	1,496,981
2018-11-30	Senner Christopher J.	EVP and CFO	Open-market sell S	Common Stock	8,791	$19.70	$173,183	146,950
2018-11-29	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	1,116	$19.51	$21,773	235,763
2018-11-29	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	6,500	$20.00	$130,000	1,505,481
2018-11-28	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	11,759	$19.12	$224,832	236,879
2018-11-27	MORRISSEY MICHAEL	President and CEO	Equity grant / award G	Common Stock	17,647	$0.00	$0	193,998
2018-11-15	Senner Christopher J.	EVP and CFO	Other disposed transaction F	Common Stock	1,882	$17.45	$32,841	155,741
2018-11-15	Senner Christopher J.	EVP and CFO	Other disposed transaction F	Common Stock	5,882	$17.45	$102,641	157,623
2018-11-07	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	20,000	$17.32	$346,400	104,917
2018-11-02	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	37,499	$0.00	$0	0
2018-11-02	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	100	$19.03	$1,903	125,000
2018-11-02	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	4,044	$18.22	$73,682	125,100
2018-11-02	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	33,355	$17.49	$583,379	129,144
2018-11-02	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	37,499	$5.04	$188,995	162,499
2018-11-01	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	12,000	$0.00	$0	13,499
2018-11-01	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	12,000	$14.16	$169,920	328,288
2018-11-01	Schwab Gisela	Pres, Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	12,000	$5.04	$60,480	340,288
2018-10-01	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	25,000	$17.86	$446,500	1,536,981
2018-09-24	SCANGOS GEORGE A	Dir	Open-market sell S	Common Stock	25,000	$16.85	$421,250	1,561,981
2018-09-10	Lamb Peter	EVP, Scientific Strategy & CSO	Equity grant / award A · derivative	Option (right to buy)	124,341	$0.00	$0	124,341
2018-09-04	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	22,500	$18.53	$416,925	328,288
2018-09-04	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Common Stock	22,500	$0.00	$0	0
2018-08-20	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	90,000	$0.00	$0	0
2018-08-20	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	86,200	$17.79	$1,533,498	125,000
2018-08-20	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	3,800	$18.61	$70,718	211,200
2018-08-20	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	90,000	$5.50	$495,000	215,000
2018-08-17	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	50,000	$0.00	$0	30,000
2018-08-17	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	50,000	$5.51	$275,500	328,288
2018-08-15	MARCHESI VINCENT T	Dir	Exercise / conversion M · derivative	Option (right to buy)	40,000	$0.00	$0	0
2018-08-15	MARCHESI VINCENT T	Dir	Open-market sell S	Common Stock	40,000	$19.50	$780,000	133,850
2018-08-15	MARCHESI VINCENT T	Dir	Exercise / conversion M	Common Stock	40,000	$3.38	$135,200	173,850
2018-08-10	SCANGOS GEORGE A	Dir	Exercise / conversion M · derivative	Option (right to buy)	33,333	$0.00	$0	0
2018-08-10	SCANGOS GEORGE A	Dir	Exercise / conversion M · derivative	Option (right to buy)	75,000	$0.00	$0	0
2018-08-10	SCANGOS GEORGE A	Dir	Exercise / conversion M	Common Stock	33,333	$4.42	$147,332	1,586,981
2018-08-10	SCANGOS GEORGE A	Dir	Exercise / conversion M	Common Stock	75,000	$5.04	$378,000	1,553,648
2018-08-09	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	34,267	$0.00	$0	570,284
2018-08-09	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	34,267	$20.91	$716,523	125,000
2018-08-09	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	34,267	$1.70	$58,254	159,267
2018-08-08	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	604,551
2018-08-08	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	100,000	$21.02	$2,102,000	125,000
2018-08-08	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	100,000	$1.70	$170,000	225,000
2018-08-07	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	100,000	$0.00	$0	704,551
2018-08-07	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	100,000	$21.10	$2,110,000	125,000
2018-08-07	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	100,000	$1.70	$170,000	225,000
2018-08-06	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	2,361	$20.92	$49,392	124,917
2018-08-01	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	22,500	$0.00	$0	22,500
2018-08-01	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	22,500	$20.56	$462,600	278,288
2018-08-01	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	22,500	$5.50	$123,750	300,788
2018-07-16	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	90,000	$0.00	$0	90,000
2018-07-16	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	90,000	$21.13	$1,901,700	125,000
2018-07-16	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	90,000	$5.50	$495,000	215,000
2018-07-02	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	22,500	$0.00	$0	45,000
2018-07-02	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	22,500	$21.20	$477,000	278,288
2018-07-02	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	22,500	$5.50	$123,750	300,788
2018-06-25	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	90,000	$0.00	$0	180,000
2018-06-25	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	90,000	$19.62	$1,765,800	125,000
2018-06-25	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	90,000	$5.50	$495,000	215,000
2018-06-01	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	22,500	$0.00	$0	67,500
2018-06-01	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	22,500	$20.80	$468,000	278,288
2018-06-01	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	22,500	$5.50	$123,750	300,788
2018-05-31	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	65,000	$20.71	$1,346,150	254,450
2018-05-30	FELDBAUM CARL B	Dir	Exercise / conversion M · derivative	Option (right to buy)	3,500	$0.00	$0	11,500
2018-05-30	FELDBAUM CARL B	Dir	Exercise / conversion M · derivative	Option (right to buy)	11,250	$0.00	$0	0
2018-05-30	FELDBAUM CARL B	Dir	Open-market sell S	Common Stock	34,262	$20.60	$705,797	15,221
2018-05-30	FELDBAUM CARL B	Dir	Exercise / conversion M	Common Stock	3,500	$4.57	$15,995	49,483
2018-05-30	FELDBAUM CARL B	Dir	Exercise / conversion M	Common Stock	11,250	$4.16	$46,800	45,983
2018-05-24	WILLSEY LANCE	Dir	Equity grant / award A · derivative	Option (right to buy)	31,167	$0.00	$0	31,167
2018-05-24	WYSZOMIERSKI JACK L	Dir	Equity grant / award A · derivative	Option (right to buy)	15,874	$0.00	$0	15,874
2018-05-24	WYSZOMIERSKI JACK L	Dir	Equity grant / award A	Common Stock	7,937	$0.00	$0	101,781
2018-05-22	WILLSEY LANCE	Dir	Open-market sell S	Common Stock	50,000	$21.40	$1,070,000	418,273
2018-05-18	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	3,663	$21.61	$79,157	127,278
2018-05-15	SCANGOS GEORGE A	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2018-05-15	SCANGOS GEORGE A	Dir	Exercise / conversion M	Common Stock	15,000	$11.66	$174,900	1,478,648
2018-05-11	MARCHESI VINCENT T	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2018-05-11	MARCHESI VINCENT T	Dir	Open-market sell S	Common Stock	15,000	$19.03	$285,450	125,913
2018-05-11	MARCHESI VINCENT T	Dir	Exercise / conversion M	Common Stock	15,000	$11.66	$174,900	140,913
2018-05-09	COHEN CHARLES	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2018-05-09	COHEN CHARLES	Dir	Open-market sell S	Common Stock	15,000	$21.42	$321,300	248,180
2018-05-09	COHEN CHARLES	Dir	Exercise / conversion M	Common Stock	15,000	$11.66	$174,900	263,180
2018-05-07	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2018-05-07	PAPADOPOULOS STELIOS	Dir	Open-market sell S	Common Stock	15,000	$22.15	$332,250	1,034,314
2018-05-07	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M	Common Stock	15,000	$11.66	$174,900	1,049,314
2018-05-04	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	20,000	$22.36	$447,200	319,450
2018-05-03	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	22,500	$0.00	$0	90,000
2018-05-03	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	14,700	$23.47	$345,009	278,288
2018-05-03	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	7,800	$22.36	$174,408	292,988
2018-05-03	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	22,500	$5.50	$123,750	300,788
2018-04-27	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	25,000	$0.00	$0	120,000
2018-04-27	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	25,000	$1.70	$42,500	339,450
2018-04-24	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M · derivative	Option (right to buy)	20,000	$0.00	$0	65,000
2018-04-24	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M	Common Stock	20,000	$1.70	$34,000	133,490
2018-04-16	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2018-04-16	WYSZOMIERSKI JACK L	Dir	Open-market sell S	Common Stock	14,959	$20.25	$302,920	93,844
2018-04-16	WYSZOMIERSKI JACK L	Dir	Exercise / conversion M	Common Stock	15,000	$11.66	$174,900	108,803
2018-04-11	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M · derivative	Option (right to buy)	90,000	$0.00	$0	360,000
2018-04-11	MORRISSEY MICHAEL	President and CEO	Open-market sell S	Common Stock	90,000	$20.78	$1,870,200	131,653
2018-04-11	MORRISSEY MICHAEL	President and CEO	Exercise / conversion M	Common Stock	90,000	$5.50	$495,000	221,653
2018-04-06	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	14,591	$0.00	$0	163,109
2018-04-06	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	14,591	$7.18	$104,763	277,280
2018-04-05	Freire Maria C	Dir	Equity grant / award A · derivative	Option (right to buy)	28,240	$0.00	$0	28,240
2018-04-05	Freire Maria C	Dir	Equity grant / award A	Common Stock	14,120	$0.00	$0	14,120
2018-03-06	MARCHESI VINCENT T	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2018-03-06	MARCHESI VINCENT T	Dir	Open-market sell S	Common Stock	15,000	$24.73	$370,950	125,913
2018-03-06	MARCHESI VINCENT T	Dir	Exercise / conversion M	Common Stock	15,000	$7.97	$119,550	140,913
2018-03-05	FELDBAUM CARL B	Dir	Exercise / conversion M · derivative	Option (right to buy)	11,000	$0.00	$0	0
2018-03-05	FELDBAUM CARL B	Dir	Open-market sell S	Common Stock	11,000	$23.88	$262,680	34,733
2018-03-05	FELDBAUM CARL B	Dir	Exercise / conversion M	Common Stock	11,000	$11.66	$128,260	45,733
2018-03-02	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M · derivative	Option (right to buy)	15,000	$0.00	$0	0
2018-03-02	PAPADOPOULOS STELIOS	Dir	Open-market sell S	Common Stock	15,000	$24.05	$360,750	1,034,314
2018-03-02	PAPADOPOULOS STELIOS	Dir	Exercise / conversion M	Common Stock	15,000	$7.97	$119,550	1,049,314
2018-03-01	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	7,293	$0.00	$0	0
2018-03-01	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	7,293	$4.42	$32,235	262,689
2018-02-28	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M · derivative	Option (right to buy)	3,000	$0.00	$0	0
2018-02-28	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M · derivative	Option (right to buy)	10,625	$0.00	$0	39,375
2018-02-28	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	45,029	$27.13	$1,221,637	113,490
2018-02-28	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M	Common Stock	3,000	$5.50	$16,500	158,519
2018-02-28	Haley Patrick J.	Sr. Vice President, Commercial	Exercise / conversion M	Common Stock	10,625	$1.76	$18,700	155,519
2018-01-09	Garber Alan M	Dir	Exercise / conversion M · derivative	Option (right to buy)	11,500	$0.00	$0	0
2018-01-09	Garber Alan M	Dir	Open-market sell S	Common Stock	11,500	$30.00	$345,000	61,329
2018-01-09	Garber Alan M	Dir	Exercise / conversion M	Common Stock	11,500	$7.97	$91,655	72,829
2018-01-08	Garber Alan M	Dir	Exercise / conversion M · derivative	Option (right to buy)	3,500	$0.00	$0	11,500
2018-01-08	Garber Alan M	Dir	Open-market sell S	Common Stock	3,500	$31.29	$109,515	61,329
2018-01-08	Garber Alan M	Dir	Exercise / conversion M	Common Stock	3,500	$7.97	$27,895	64,829
2017-11-15	Lamb Peter	EVP, Scientific Strategy & CSO	Other disposed transaction F	Common Stock	2,204	$24.75	$54,549	126,396
2017-10-03	Haley Patrick J.	Sr. Vice President, Commercial	Equity grant / award A · derivative	Option (right to buy)	100,000	$0.00	$0	100,000
2017-10-03	Haley Patrick J.	Sr. Vice President, Commercial	Equity grant / award A	Common Stock	50,000	$0.00	$0	93,914
2017-09-28	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	33,334	$0.00	$0	0
2017-09-28	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	33,334	$23.74	$791,349	183,005
2017-09-28	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	33,334	$9.91	$330,340	216,339
2017-09-28	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	25,000	$0.00	$0	172,698
2017-09-28	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	25,000	$24.32	$608,000	267,946
2017-09-28	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	25,000	$1.90	$47,500	292,946
2017-09-27	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	33,333	$0.00	$0	33,334
2017-09-27	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	33,333	$23.94	$797,992	183,005
2017-09-27	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	33,333	$9.91	$330,330	216,338
2017-09-27	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M · derivative	Option (right to buy)	2,302	$0.00	$0	197,698
2017-09-27	Hessekiel Jeffrey	EVP and General Counsel	Open-market sell S	Common Stock	2,302	$23.90	$55,018	267,946
2017-09-27	Hessekiel Jeffrey	EVP and General Counsel	Exercise / conversion M	Common Stock	2,302	$1.90	$4,374	270,248
2017-09-26	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M · derivative	Option (right to buy)	33,333	$0.00	$0	66,667
2017-09-26	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Open-market sell S	Common Stock	33,333	$23.68	$789,325	183,005
2017-09-26	Schwab Gisela	Pres Prod Dev & Med Aff & CMO	Exercise / conversion M	Common Stock	33,333	$9.91	$330,330	216,338
2017-09-22	PAPADOPOULOS STELIOS	Dir	Open-market sell S	Common Stock	10,000	$25.40	$254,000	0
2017-09-19	PAPADOPOULOS STELIOS	Dir	Open-market sell S	Common Stock	127,790	$27.63	$3,530,838	1,034,314
2017-09-18	PAPADOPOULOS STELIOS	Dir	Open-market sell S	Common Stock	72,210	$27.76	$2,004,550	1,162,104
2017-09-14	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	60,640	$27.21	$1,650,014	41,553
2017-09-13	WILLSEY LANCE	Dir	Open-market sell S	Common Stock	50,000	$26.97	$1,348,500	468,273
2017-09-12	WILLSEY LANCE	Dir	Open-market sell S	Common Stock	50,000	$26.79	$1,339,500	518,273
2017-05-30	Haley Patrick J.	Sr. Vice President, Commercial	Open-market sell S	Common Stock	5,000	$18.46	$92,300	102,193
2017-05-25	Smith Julie	Dir	Equity grant / award A · derivative	Option (right to buy)	23,491	$0.00	$0	23,491
2017-05-25	PAPADOPOULOS STELIOS	Dir	Equity grant / award A · derivative	Option (right to buy)	11,686	$0.00	$0	11,686
2017-05-25	PAPADOPOULOS STELIOS	Dir	Equity grant / award A	Common Stock	5,843	$0.00	$0	1,234,314

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count