Financial Metrics

HALO HALOZYME THERAPEUTICS, INC.

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-06-30	-0.21	—	USD/shares	10-Q	2016-08-09
Quarterly	2016-09-30	-0.23	-9.5%	USD/shares	10-Q	2017-11-07
Quarterly	2017-09-30	0.02	+108.7%	USD/shares	10-Q	2018-11-06
Quarterly	2018-03-31	-0.19	-1050.0%	USD/shares	10-Q	2019-05-07
Quarterly	2018-09-30	-0.19	+0.0%	USD/shares	10-Q	2018-11-06
Quarterly	2019-03-31	0.01	+105.3%	USD/shares	10-Q	2020-05-11
Quarterly	2019-06-30	-0.1	-1100.0%	USD/shares	10-Q	2020-08-10
Quarterly	2019-09-30	-0.17	-70.0%	USD/shares	10-Q	2020-11-02
Quarterly	2020-03-31	-0.04	+76.5%	USD/shares	10-Q	2021-05-10
Quarterly	2020-06-30	0.19	+575.0%	USD/shares	10-Q	2021-08-09
Quarterly	2020-09-30	0.25	+31.6%	USD/shares	10-Q	2021-11-02
Quarterly	2021-03-31	0.19	-24.0%	USD/shares	10-Q	2022-05-10
Quarterly	2021-06-30	0.62	+226.3%	USD/shares	10-Q	2022-08-09
Quarterly	2021-09-30	1.48	+138.7%	USD/shares	10-Q	2022-11-08
Quarterly	2022-03-31	0.43	-70.9%	USD/shares	10-Q	2023-05-09
Quarterly	2022-06-30	0.16	-62.8%	USD/shares	10-Q	2023-08-08
Quarterly	2022-09-30	0.44	+175.0%	USD/shares	10-Q	2023-11-06
Quarterly	2023-03-31	0.29	-34.1%	USD/shares	10-Q	2024-05-07
Quarterly	2023-06-30	0.56	+93.1%	USD/shares	10-Q	2024-08-06
Quarterly	2023-09-30	0.61	+8.9%	USD/shares	10-Q	2024-10-31
Quarterly	2024-03-31	0.6	-1.6%	USD/shares	10-Q	2025-05-06
Quarterly	2024-06-30	0.72	+20.0%	USD/shares	10-Q	2025-08-05
Quarterly	2024-09-30	1.05	+45.8%	USD/shares	10-Q	2025-11-03
Quarterly	2025-03-31	0.93	-11.4%	USD/shares	10-Q	2025-05-06
Quarterly	2025-06-30	1.33	+43.0%	USD/shares	10-Q	2025-08-05
Quarterly	2025-09-30	1.43	+7.5%	USD/shares	10-Q	2025-11-03
Annual	2016-12-31	-0.81	—	USD/shares	10-K	2019-02-21
Annual	2017-12-31	0.45	+155.6%	USD/shares	10-K	2020-02-24
Annual	2018-12-31	-0.56	-224.4%	USD/shares	10-K	2021-02-23
Annual	2019-12-31	-0.5	+10.7%	USD/shares	10-K	2022-02-22
Annual	2020-12-31	0.91	+282.0%	USD/shares	10-K	2023-02-21
Annual	2021-12-31	2.74	+201.1%	USD/shares	10-K	2024-02-20
Annual	2022-12-31	1.44	-47.4%	USD/shares	10-K	2025-02-18
Annual	2023-12-31	2.1	+45.8%	USD/shares	10-K	2026-02-17
Annual	2024-12-31	3.43	+63.3%	USD/shares	10-K	2026-02-17
Annual	2025-12-31	2.56	-25.4%	USD/shares	10-K	2026-02-17

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	168600000.0	—	USD	10-Q	2016-05-09
Quarterly	2016-06-30	204850000.0	+21.5%	USD	10-Q	2016-08-09
Quarterly	2016-09-30	199803000.0	-2.5%	USD	10-Q	2016-11-07
Quarterly	2016-12-31	199228000.0	-0.3%	USD	10-Q	2017-11-07
Quarterly	2017-03-31	184430000.0	-7.4%	USD	10-Q	2017-05-09
Quarterly	2017-06-30	165517000.0	-10.3%	USD	10-Q	2017-08-08
Quarterly	2017-09-30	145417000.0	-12.1%	USD	10-Q	2017-11-07
Quarterly	2017-12-31	125140000.0	-13.9%	USD	10-Q	2018-11-06
Quarterly	2018-03-31	102696000.0	-17.9%	USD	10-Q	2018-05-10
Quarterly	2018-06-30	79080000.0	-23.0%	USD	10-Q	2018-08-07
Quarterly	2018-09-30	57940000.0	-26.7%	USD	10-Q	2018-11-06
Quarterly	2018-12-31	34874000.0	-39.8%	USD	10-Q	2019-11-12
Quarterly	2019-03-31	18742000.0	-46.3%	USD	10-Q	2019-05-07
Quarterly	2019-06-30	14083000.0	-24.9%	USD	10-Q	2019-08-06
Quarterly	2019-09-30	9308000.0	-33.9%	USD	10-Q	2019-11-12
Quarterly	2019-12-31	383045000.0	+4015.2%	USD	10-Q	2020-11-02
Quarterly	2020-03-31	386571000.0	+0.9%	USD	10-Q	2020-05-11
Quarterly	2020-06-30	390079000.0	+0.9%	USD	10-Q	2020-08-10
Quarterly	2020-09-30	393631000.0	+0.9%	USD	10-Q	2020-11-02
Quarterly	2020-12-31	0.0	-100.0%	USD	10-Q	2021-11-02
Quarterly	2021-03-31	784731000.0	—	USD	10-Q	2021-05-10
Quarterly	2021-06-30	785571000.0	+0.1%	USD	10-Q	2021-08-09
Quarterly	2021-09-30	786454000.0	+0.1%	USD	10-Q	2021-11-02
Quarterly	2021-12-31	876674000.0	+11.5%	USD	10-Q	2022-11-08
Quarterly	2022-03-31	788099000.0	-10.1%	USD	10-Q	2022-05-10
Quarterly	2022-06-30	1147129000.0	+45.6%	USD	10-Q	2022-08-09
Quarterly	2022-09-30	1504471000.0	+31.2%	USD	10-Q	2022-11-08
Quarterly	2022-12-31	1506100000.0	+0.1%	USD	10-Q	2023-11-06
Quarterly	2023-03-31	1494380000.0	-0.8%	USD	10-Q	2023-05-09
Quarterly	2023-06-30	1495998000.0	+0.1%	USD	10-Q	2023-08-08
Quarterly	2023-09-30	1497621000.0	+0.1%	USD	10-Q	2023-11-06
Quarterly	2023-12-31	1499248000.0	+0.1%	USD	10-Q	2024-10-31
Quarterly	2024-03-31	1500879000.0	+0.1%	USD	10-Q	2024-05-07
Quarterly	2024-06-30	1502515000.0	+0.1%	USD	10-Q	2024-08-06
Quarterly	2024-09-30	1504154000.0	+0.1%	USD	10-Q	2024-10-31
Quarterly	2024-12-31	1505798000.0	+0.1%	USD	10-Q	2025-11-03
Quarterly	2025-03-31	1507447000.0	+0.1%	USD	10-Q	2025-05-06
Quarterly	2025-06-30	1509100000.0	+0.1%	USD	10-Q	2025-08-05
Quarterly	2025-09-30	1510757000.0	+0.1%	USD	10-Q	2025-11-03
Annual	2016-12-31	199228000.0	—	USD	10-K	2018-02-20
Annual	2017-12-31	125140000.0	-37.2%	USD	10-K	2019-02-21
Annual	2018-12-31	34874000.0	-72.1%	USD	10-K	2020-02-24
Annual	2019-12-31	383045000.0	+998.4%	USD	10-K	2021-02-23
Annual	2020-12-31	0.0	-100.0%	USD	10-K	2022-02-22
Annual	2021-12-31	787255000.0	—	USD	10-K	2023-02-21
Annual	2022-12-31	1506100000.0	+91.3%	USD	10-K	2024-02-20
Annual	2023-12-31	1499248000.0	-0.5%	USD	10-K	2025-02-18
Annual	2024-12-31	1505798000.0	+0.4%	USD	10-K	2026-02-17
Annual	2025-12-31	2142630000.0	+42.3%	USD	10-K	2026-02-17

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	1099000.0	—	USD	10-Q	2017-05-09
Quarterly	2016-06-30	2266000.0	+106.2%	USD	10-Q	2017-08-08
Quarterly	2016-09-30	2690000.0	+18.7%	USD	10-Q	2017-11-07
Quarterly	2017-03-31	99000.0	-96.3%	USD	10-Q	2018-05-10
Quarterly	2017-06-30	329000.0	+232.3%	USD	10-Q	2018-08-07
Quarterly	2017-09-30	490000.0	+48.9%	USD	10-Q	2018-11-06
Quarterly	2018-03-31	839000.0	+71.2%	USD	10-Q	2019-05-07
Quarterly	2018-06-30	1257000.0	+49.8%	USD	10-Q	2019-08-06
Quarterly	2018-09-30	1590000.0	+26.5%	USD	10-Q	2019-11-12
Quarterly	2019-03-31	927000.0	-41.7%	USD	10-Q	2020-05-11
Quarterly	2019-06-30	2295000.0	+147.6%	USD	10-Q	2020-08-10
Quarterly	2019-09-30	3399000.0	+48.1%	USD	10-Q	2020-11-02
Quarterly	2020-03-31	114000.0	-96.6%	USD	10-Q	2021-05-10
Quarterly	2020-06-30	629000.0	+451.8%	USD	10-Q	2021-08-09
Quarterly	2020-09-30	805000.0	+28.0%	USD	10-Q	2021-11-02
Quarterly	2021-03-31	270000.0	-66.5%	USD	10-Q	2022-05-10
Quarterly	2021-06-30	803000.0	+197.4%	USD	10-Q	2022-08-09
Quarterly	2021-09-30	1299000.0	+61.8%	USD	10-Q	2022-11-08
Quarterly	2022-03-31	490000.0	-62.3%	USD	10-Q	2023-05-09
Quarterly	2022-06-30	1458000.0	+197.6%	USD	10-Q	2023-08-08
Quarterly	2022-09-30	2466000.0	+69.1%	USD	10-Q	2023-11-06
Quarterly	2023-03-31	11377000.0	+361.4%	USD	10-Q	2024-05-07
Quarterly	2023-06-30	9754000.0	-14.3%	USD	10-Q	2024-08-06
Quarterly	2023-09-30	12698000.0	+30.2%	USD	10-Q	2024-10-31
Quarterly	2024-03-31	3545000.0	-72.1%	USD	10-Q	2025-05-06
Quarterly	2024-06-30	6127000.0	+72.8%	USD	10-Q	2025-08-05
Quarterly	2024-09-30	7644000.0	+24.8%	USD	10-Q	2025-11-03
Quarterly	2025-03-31	950000.0	-87.6%	USD	10-Q	2025-05-06
Quarterly	2025-06-30	2513000.0	+164.5%	USD	10-Q	2025-08-05
Quarterly	2025-09-30	5543000.0	+120.6%	USD	10-Q	2025-11-03
Annual	2016-12-31	3137000.0	—	USD	10-K	2019-02-21
Annual	2017-12-31	1350000.0	-57.0%	USD	10-K	2020-02-24
Annual	2018-12-31	4663000.0	+245.4%	USD	10-K	2021-02-23
Annual	2019-12-31	4040000.0	-13.4%	USD	10-K	2022-02-22
Annual	2020-12-31	2504000.0	-38.0%	USD	10-K	2023-02-21
Annual	2021-12-31	1457000.0	-41.8%	USD	10-K	2024-02-20
Annual	2022-12-31	4810000.0	+230.1%	USD	10-K	2025-02-18
Annual	2023-12-31	15294000.0	+218.0%	USD	10-K	2026-02-17
Annual	2024-12-31	10696000.0	-30.1%	USD	10-K	2026-02-17
Annual	2025-12-31	6970000.0	-34.8%	USD	10-K	2026-02-17

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-06-30	127958000.0	—	shares	10-Q	2016-08-09
Quarterly	2016-09-30	128154000.0	+0.2%	shares	10-Q	2017-11-07
Quarterly	2017-09-30	143236000.0	+11.8%	shares	10-Q	2018-11-06
Quarterly	2018-03-31	142656000.0	-0.4%	shares	10-Q	2019-05-07
Quarterly	2018-06-30	143568000.0	+0.6%	shares	10-Q	2019-08-06
Quarterly	2018-09-30	143949000.0	+0.3%	shares	10-Q	2019-11-12
Quarterly	2019-03-31	144743000.0	+0.6%	shares	10-Q	2020-05-11
Quarterly	2019-06-30	145411000.0	+0.5%	shares	10-Q	2020-08-10
Quarterly	2019-09-30	146136000.0	+0.5%	shares	10-Q	2020-11-02
Quarterly	2020-03-31	137186000.0	-6.1%	shares	10-Q	2021-05-10
Quarterly	2020-06-30	138084000.0	+0.7%	shares	10-Q	2021-08-09
Quarterly	2020-09-30	142081000.0	+2.9%	shares	10-Q	2021-11-02
Quarterly	2021-03-31	148540000.0	+4.5%	shares	10-Q	2022-05-10
Quarterly	2021-06-30	147624000.0	-0.6%	shares	10-Q	2022-08-09
Quarterly	2021-09-30	146690000.0	-0.6%	shares	10-Q	2022-11-08
Quarterly	2022-03-31	141277000.0	-3.7%	shares	10-Q	2023-05-09
Quarterly	2022-06-30	142216000.0	+0.7%	shares	10-Q	2023-08-08
Quarterly	2022-09-30	139387000.0	-2.0%	shares	10-Q	2023-11-06
Quarterly	2023-03-31	137900000.0	-1.1%	shares	10-Q	2024-05-07
Quarterly	2023-06-30	133543000.0	-3.2%	shares	10-Q	2024-08-06
Quarterly	2023-09-30	134083000.0	+0.4%	shares	10-Q	2024-10-31
Quarterly	2024-03-31	128887000.0	-3.9%	shares	10-Q	2025-05-06
Quarterly	2024-06-30	129222000.0	+0.3%	shares	10-Q	2025-08-05
Quarterly	2024-09-30	130134000.0	+0.7%	shares	10-Q	2025-11-03
Quarterly	2025-03-31	126644000.0	-2.7%	shares	10-Q	2025-05-06
Quarterly	2025-06-30	124158000.0	-2.0%	shares	10-Q	2025-08-05
Quarterly	2025-09-30	122331000.0	-1.5%	shares	10-Q	2025-11-03
Annual	2016-12-31	127964000.0	—	shares	10-K	2019-02-21
Annual	2017-12-31	139068000.0	+8.7%	shares	10-K	2020-02-24
Annual	2018-12-31	143599000.0	+3.3%	shares	10-K	2021-02-23
Annual	2019-12-31	144329000.0	+0.5%	shares	10-K	2022-02-22
Annual	2020-12-31	141463000.0	-2.0%	shares	10-K	2023-02-21
Annual	2021-12-31	146796000.0	+3.8%	shares	10-K	2024-02-20
Annual	2022-12-31	140608000.0	-4.2%	shares	10-K	2025-02-18
Annual	2023-12-31	134197000.0	-4.6%	shares	10-K	2026-02-17
Annual	2024-12-31	129424000.0	-3.6%	shares	10-K	2026-02-17
Annual	2025-12-31	123904000.0	-4.3%	shares	10-K	2026-02-17

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

2,142,630,000

Total Liabilities (latest annual)

2,476,509,000

Current Liabilities (latest annual)

177,092,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-0.6724	—	ratio	10-Q	2017-05-09
Quarterly	2016-06-30	-2.7092	-302.9%	ratio	10-Q	2017-08-08
Quarterly	2016-09-30	2.4138	+189.1%	ratio	10-Q	2017-11-07
Quarterly	2017-03-31	0.5624	-76.7%	ratio	10-Q	2018-05-10
Quarterly	2017-06-30	-0.5289	-194.1%	ratio	10-Q	2018-08-07
Quarterly	2017-09-30	0.0380	+107.2%	ratio	10-Q	2018-11-06
Quarterly	2018-03-31	-0.1036	-372.8%	ratio	10-Q	2019-05-07
Quarterly	2018-06-30	-0.0898	+13.3%	ratio	10-Q	2019-08-06
Quarterly	2018-09-30	-0.1162	-29.4%	ratio	10-Q	2019-11-12
Quarterly	2019-03-31	0.0069	+105.9%	ratio	10-Q	2020-05-11
Quarterly	2019-06-30	-0.0562	-914.2%	ratio	10-Q	2020-08-10
Quarterly	2019-09-30	-0.1020	-81.3%	ratio	10-Q	2020-11-02
Quarterly	2020-03-31	-0.1051	-3.1%	ratio	10-Q	2021-05-10
Quarterly	2020-06-30	0.2445	+332.6%	ratio	10-Q	2021-08-09
Quarterly	2020-09-30	0.3658	+49.6%	ratio	10-Q	2021-11-02
Quarterly	2021-03-31	0.4127	+12.8%	ratio	10-Q	2022-05-10
Quarterly	2021-06-30	0.7638	+85.1%	ratio	10-Q	2022-08-09
Quarterly	2021-09-30	0.7689	+0.7%	ratio	10-Q	2022-11-08
Quarterly	2022-03-31	0.2310	-70.0%	ratio	10-Q	2023-05-09
Quarterly	2022-06-30	0.0774	-66.5%	ratio	10-Q	2023-08-08
Quarterly	2022-09-30	0.6355	+721.2%	ratio	10-Q	2023-11-06
Quarterly	2023-03-31	0.6016	-5.3%	ratio	10-Q	2024-05-07
Quarterly	2023-06-30	0.4950	-17.7%	ratio	10-Q	2024-08-06
Quarterly	2023-09-30	0.3284	-33.6%	ratio	10-Q	2024-10-31
Quarterly	2024-03-31	0.4321	+31.6%	ratio	10-Q	2025-05-06
Quarterly	2024-06-30	0.3222	-25.4%	ratio	10-Q	2025-08-05
Quarterly	2024-09-30	0.3027	-6.1%	ratio	10-Q	2025-11-03
Quarterly	2025-03-31	0.2449	-19.1%	ratio	10-Q	2025-05-06
Quarterly	2025-06-30	0.4964	+102.7%	ratio	10-Q	2025-08-05
Quarterly	2025-09-30	0.3477	-29.9%	ratio	10-Q	2025-11-03
Annual	2016-12-31	3.1718	—	ratio	10-K	2019-02-21
Annual	2017-12-31	0.3022	-90.5%	ratio	10-K	2020-02-24
Annual	2018-12-31	-0.3228	-206.8%	ratio	10-K	2021-02-23
Annual	2019-12-31	-0.7872	-143.9%	ratio	10-K	2022-02-22
Annual	2020-12-31	0.8546	+208.6%	ratio	10-K	2023-02-21
Annual	2021-12-31	2.0447	+139.3%	ratio	10-K	2024-02-20
Annual	2022-12-31	1.1904	-41.8%	ratio	10-K	2025-02-18
Annual	2023-12-31	3.3600	+182.3%	ratio	10-K	2026-02-17
Annual	2024-12-31	1.2206	-63.7%	ratio	10-K	2026-02-17
Annual	2025-12-31	6.4918	+431.8%	ratio	10-K	2026-02-17

8-K Material Event Details

63 filings · 127 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

797 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-04-06	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$12.07	$120,700	101,923
2026-04-06	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	4,100	$64.02	$262,462	767,780
2026-04-06	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	5,900	$63.14	$372,520	771,880
2026-04-06	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$12.07	$120,700	777,780
2026-04-01	RAMSAY DAVID A	Interim CFO	Equity grant / award A · derivative	Restricted Stock Units	10,000	$0.00	$0	10,000
2026-03-10	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	1,546	$33.51	$51,806	67,678
2026-03-10	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Open-market sell S	Common Stock	8,857	$67.64	$599,087	7,055
2026-03-10	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Exercise / conversion M	Common Stock	1,546	$33.51	$51,806	15,912
2026-03-09	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$33.51	$670,200	69,224
2026-03-09	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Open-market sell S	Common Stock	2,100	$68.25	$143,329	14,366
2026-03-09	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Open-market sell S	Common Stock	17,900	$67.75	$1,212,743	16,466
2026-03-09	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Exercise / conversion M	Common Stock	20,000	$33.51	$670,200	34,366
2026-03-04	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$12.07	$120,700	151,923
2026-03-04	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	2,671	$70.94	$189,494	767,780
2026-03-04	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	7,329	$69.94	$512,620	770,451
2026-03-04	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$12.07	$120,700	777,780
2026-03-03	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$12.07	$241,400	161,923
2026-03-03	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	6,519	$69.33	$451,982	767,780
2026-03-03	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	13,481	$68.85	$928,167	774,299
2026-03-03	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$12.07	$241,400	787,780
2026-03-02	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$12.07	$241,400	181,923
2026-03-02	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	578	$70.46	$40,726	767,780
2026-03-02	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	15,322	$69.80	$1,069,460	768,358
2026-03-02	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	4,100	$69.20	$283,708	783,680
2026-03-02	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$12.07	$241,400	787,780
2026-02-20	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	2,666	$0.00	$0	7,998
2026-02-20	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Other disposed transaction F	Common Stock	1,037	$70.98	$73,606	14,366
2026-02-20	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Exercise / conversion M	Common Stock	2,666	$0.00	$0	15,403
2026-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M · derivative	Performance Stock Units	12,016	$0.00	$0	0
2026-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	4,796	$0.00	$0	4,796
2026-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Other disposed transaction F	Common Stock	6,481	$79.44	$514,851	41,925
2026-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M	Common Stock	12,016	$0.00	$0	48,406
2026-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Other disposed transaction F	Common Stock	2,587	$79.44	$205,511	36,390
2026-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M	Common Stock	4,796	$0.00	$0	38,977
2026-02-09	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Equity grant / award A · derivative	Performance Stock Units	14,751	$0.00	$0	14,751
2026-02-09	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Equity grant / award A · derivative	Performance Stock Units	2,403	$0.00	$0	13,886
2026-02-09	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Equity grant / award A · derivative	Restricted Stock Units	13,047	$0.00	$0	13,047
2026-02-09	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Equity grant / award A · derivative	Option to Purchase Common Stock	14,047	$0.00	$0	14,047
2026-02-05	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$12.07	$120,700	201,923
2026-02-05	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	4,624	$78.94	$365,000	708,719
2026-02-05	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	5,376	$78.38	$421,366	713,343
2026-02-05	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$12.07	$120,700	718,719
2026-02-04	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$12.07	$241,400	211,923
2026-02-04	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,100	$77.54	$783,154	708,719
2026-02-04	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	9,900	$76.94	$761,666	718,819
2026-02-04	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$12.07	$241,400	728,719
2026-02-03	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$12.07	$241,400	231,923
2026-02-03	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	7,790	$76.73	$597,758	708,719
2026-02-03	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	9,659	$75.94	$733,543	716,509
2026-02-03	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	2,551	$74.88	$191,016	726,168
2026-02-03	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$12.07	$241,400	728,719
2026-01-05	Connaughton Bernadette	Dir	Open-market sell S	Common Stock	2,000	$70.25	$140,500	40,123
2026-01-03	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	7,611	$0.00	$0	0
2026-01-03	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Other disposed transaction F	Common Stock	4,243	$70.31	$298,325	34,181
2026-01-03	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M	Common Stock	7,611	$0.00	$0	38,424
2026-01-02	Lang James Paul	Dir	Equity grant / award A · derivative	Option to Purchase Common Stock	1,342	$0.00	$0	1,342
2026-01-02	Lang James Paul	Dir	Equity grant / award A	Restricted Stock Units	889	$0.00	$0	889
2025-12-09	Torley Helen	PRESIDENT AND CEO	Equity grant / award A · derivative	Performance Stock Units	165,522	$0.00	$0	165,522
2025-12-01	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	16,569	$8.11	$134,375	0
2025-12-01	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	261	$71.60	$18,688	708,719
2025-12-01	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	500	$70.36	$35,181	708,980
2025-12-01	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	5,402	$69.44	$375,120	709,480
2025-12-01	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,406	$68.51	$712,936	714,882
2025-12-01	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	16,569	$8.11	$134,375	725,288
2025-12-01	Connaughton Bernadette	Dir	Open-market sell S	Common Stock	829	$71.60	$59,356	42,123
2025-11-26	Torley Helen	PRESIDENT AND CEO	Equity grant / award G	Common Stock	25,000	$0.00	$0	708,719
2025-11-12	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	16,569
2025-11-12	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	498	$71.67	$35,690	733,719
2025-11-12	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	6,784	$71.09	$482,268	734,217
2025-11-12	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	12,718	$70.22	$893,033	741,001
2025-11-12	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-11-11	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	36,569
2025-11-11	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	11,500	$69.73	$801,906	733,719
2025-11-11	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	4,000	$68.80	$275,180	745,219
2025-11-11	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	4,500	$67.89	$305,514	749,219
2025-11-11	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-11-10	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	56,569
2025-11-10	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	100	$69.30	$6,930	733,719
2025-11-10	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	19,900	$68.71	$1,367,409	733,819
2025-11-10	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-11-01	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	9,326	$0.00	$0	18,651
2025-11-01	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Open-market sell S	Common Stock	4,263	$65.19	$277,905	12,737
2025-11-01	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Exercise / conversion M	Common Stock	9,326	$0.00	$0	17,000
2025-10-03	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	76,569
2025-10-03	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	724	$71.67	$51,891	733,719
2025-10-03	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	2,707	$70.58	$191,065	734,443
2025-10-03	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	2,334	$69.83	$162,983	737,150
2025-10-03	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	14,235	$68.47	$974,699	739,484
2025-10-03	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-10-03	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Equity grant / award A · derivative	Restricted Stock Units	3,625	$0.00	$0	3,625
2025-10-03	Caudill Cortney	SVP, CHIEF OPERATING OFFICER	Equity grant / award A · derivative	Option to Purchase Common Stock	9,031	$0.00	$0	9,031
2025-10-02	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	96,569
2025-10-02	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	100	$74.67	$7,466	733,719
2025-10-02	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	700	$73.24	$51,265	733,819
2025-10-02	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	2,400	$72.06	$172,956	734,519
2025-10-02	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,200	$71.28	$727,036	736,919
2025-10-02	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	6,600	$70.51	$465,359	747,119
2025-10-02	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-10-01	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	116,569
2025-10-01	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	8,295	$75.69	$627,873	733,719
2025-10-01	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	11,705	$75.11	$879,151	742,014
2025-10-01	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-09-22	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	314	$78.67	$24,701	22,079
2025-09-22	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	1,913	$77.83	$148,883	22,393
2025-09-10	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	1,135	$0.00	$0	812
2025-09-10	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	11,271	$0.00	$0	0
2025-09-10	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	13,240	$75.93	$1,005,300	24,306
2025-09-10	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	6,760	$75.29	$508,967	37,546
2025-09-10	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	1,135	$12.49	$14,176	44,306
2025-09-10	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	11,271	$12.07	$136,041	43,171
2025-09-04	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	136,569
2025-09-04	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	2,300	$75.22	$173,015	733,719
2025-09-04	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	7,800	$74.33	$579,751	736,019
2025-09-04	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	9,900	$73.54	$728,006	743,819
2025-09-04	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-09-03	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	156,569
2025-09-03	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,500	$74.63	$783,636	733,719
2025-09-03	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	9,500	$74.22	$705,090	744,219
2025-09-03	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-09-02	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	176,569
2025-09-02	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	3,412	$74.15	$252,990	733,719
2025-09-02	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	16,288	$73.70	$1,200,393	737,131
2025-09-02	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	300	$72.48	$21,746	753,419
2025-09-02	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-08-13	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	196,569
2025-08-13	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	5,052	$64.83	$327,511	733,719
2025-08-13	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	14,948	$64.14	$958,839	738,771
2025-08-13	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-08-12	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	216,569
2025-08-12	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	6,958	$64.00	$445,319	733,719
2025-08-12	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	13,042	$63.24	$824,802	740,677
2025-08-12	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-08-11	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	236,569
2025-08-11	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	1,283	$63.60	$81,596	733,719
2025-08-11	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	18,717	$63.01	$1,179,321	735,002
2025-08-11	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-07-10	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	256,569
2025-07-10	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	15,746	$57.62	$907,237	733,719
2025-07-10	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	4,254	$56.74	$241,380	749,465
2025-07-10	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-07-09	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	276,569
2025-07-09	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	208	$57.08	$11,872	733,719
2025-07-09	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	19,792	$56.43	$1,116,783	733,927
2025-07-09	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-07-08	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	296,569
2025-07-08	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	16,402	$55.74	$914,215	733,719
2025-07-08	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	3,598	$54.48	$196,030	750,121
2025-07-08	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-06-24	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	316,569
2025-06-24	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	15,511	$53.91	$836,214	733,719
2025-06-24	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	4,489	$53.11	$238,406	749,230
2025-06-24	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-06-23	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	336,569
2025-06-23	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	20,000	$52.57	$1,051,460	733,719
2025-06-23	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-06-20	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	20,000	$8.11	$162,200	356,569
2025-06-20	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	20,000	$52.96	$1,059,200	733,719
2025-06-20	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	20,000	$8.11	$162,200	753,719
2025-06-12	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	5,035	$0.00	$0	15,102
2025-06-12	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Other disposed transaction F	Common Stock	2,711	$54.54	$147,858	30,813
2025-06-12	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M	Common Stock	5,035	$0.00	$0	33,524
2025-05-01	Posard Matthew L.	—	Equity grant / award A · derivative	Option to Purchase Common Stock	5,750	$0.00	$0	5,750
2025-05-01	Posard Matthew L.	—	Equity grant / award A	Common Stock	4,165	$0.00	$0	74,039
2025-04-28	Henderson Jeffrey William	—	Open-market sell S	Common Stock	200	$60.99	$12,199	28,611
2025-04-28	Henderson Jeffrey William	—	Open-market sell S	Common Stock	4,297	$60.34	$259,268	28,811
2025-04-01	Henderson Jeffrey William	—	Open-market sell S	Common Stock	503	$64.05	$32,217	33,108
2025-03-03	Henderson Jeffrey William	—	Open-market sell S	Common Stock	3,205	$59.12	$189,467	33,611
2025-03-03	Henderson Jeffrey William	—	Open-market sell S	Common Stock	1,795	$57.93	$103,992	36,816
2025-02-27	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	100	$58.74	$5,874	173,756
2025-02-27	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	1,597	$58.25	$93,028	173,856
2025-02-26	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	600	$58.65	$35,189	175,453
2025-02-26	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	9,400	$58.09	$546,055	176,053
2025-02-25	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	700	$58.67	$41,069	185,453
2025-02-25	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	9,300	$58.01	$539,465	186,153
2025-02-23	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	4,747	$0.00	$0	14,238
2025-02-23	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	2,410	$57.75	$139,178	195,453
2025-02-23	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	4,747	$0.00	$0	197,863
2025-02-20	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Equity grant / award A · derivative	Restricted Stock Units	11,230	$0.00	$0	11,230
2025-02-20	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Equity grant / award A · derivative	Option to Purchase Common Stock	11,902	$0.00	$0	11,902
2025-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	4,263	$0.00	$0	8,526
2025-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	6,112	$0.00	$0	6,112
2025-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Performance Stock Units	20,891	$0.00	$0	0
2025-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	2,164	$58.29	$126,140	193,116
2025-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	4,263	$0.00	$0	195,280
2025-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	3,103	$58.29	$180,874	191,017
2025-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	6,112	$0.00	$0	194,120
2025-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	8,721	$58.29	$508,347	188,008
2025-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	20,891	$0.00	$0	196,729
2025-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	4,796	$0.00	$0	9,592
2025-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M · derivative	Performance Stock Units	17,409	$0.00	$0	0
2025-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Other disposed transaction F	Common Stock	2,582	$58.29	$150,505	25,252
2025-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M	Common Stock	4,796	$0.00	$0	27,834
2025-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Other disposed transaction F	Common Stock	9,373	$58.29	$546,352	23,038
2025-02-16	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M	Common Stock	17,409	$0.00	$0	32,411
2025-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	3,386	$0.00	$0	0
2025-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	1,304	$58.29	$76,010	175,838
2025-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	3,386	$0.00	$0	177,142
2025-02-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Equity grant / award A · derivative	Performance Stock Units	20,342	$0.00	$0	20,342
2025-02-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Equity grant / award A · derivative	Performance Stock Unit	4,921	$0.00	$0	4,921
2025-02-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Equity grant / award A · derivative	Performance Stock Units	4,177	$0.00	$0	6,547
2025-02-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Equity grant / award A · derivative	Performance Stock Units	7,262	$0.00	$0	20,891
2025-02-03	Henderson Jeffrey William	—	Open-market sell S	Common Stock	3,900	$56.41	$219,980	38,611
2025-02-03	Henderson Jeffrey William	—	Open-market sell S	Common Stock	1,100	$55.94	$61,537	42,511
2025-01-06	Henderson Jeffrey William	—	Open-market sell S	Common Stock	10,000	$50.01	$500,060	43,611
2025-01-03	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	7,611	$0.00	$0	7,611
2025-01-03	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Other disposed transaction F	Common Stock	4,289	$47.74	$204,757	15,002
2025-01-03	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Exercise / conversion M	Common Stock	7,611	$0.00	$0	19,291
2024-11-29	MATSUI CONNIE	—	Equity grant / award G	Common Stock	10,470	$0.00	$0	183,035
2024-10-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	26,608
2024-10-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$53.26	$532,590	173,756
2024-10-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$19.98	$199,800	183,756
2024-10-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	4,491	$0.00	$0	36,608
2024-10-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	5,509	$0.00	$0	6,352
2024-10-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	77	$54.24	$4,177	173,756
2024-10-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	9,923	$53.74	$533,292	173,833
2024-10-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	4,491	$19.98	$89,730	183,756
2024-10-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	5,509	$16.65	$91,725	179,265
2024-10-09	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	0
2024-10-09	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	2,404	$53.91	$129,590	676,744
2024-10-09	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	1,615	$53.31	$86,096	679,148
2024-10-09	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	5,981	$51.85	$310,097	680,763
2024-10-09	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	686,744
2024-10-08	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	10,000
2024-10-08	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	900	$54.57	$49,116	676,744
2024-10-08	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	9,100	$53.94	$490,845	677,644
2024-10-08	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	686,744
2024-09-26	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	20,000
2024-09-26	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$56.10	$560,970	676,744
2024-09-26	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	686,744
2024-09-25	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	30,000
2024-09-25	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$56.34	$563,370	676,744
2024-09-25	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	686,744
2024-09-24	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	40,000
2024-09-24	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$58.21	$582,100	676,744
2024-09-24	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	686,744
2024-09-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	11,861
2024-09-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	2,037	$62.58	$127,478	173,756
2024-09-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	7,963	$61.89	$492,838	175,793
2024-09-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$16.65	$166,500	183,756
2024-09-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	21,861
2024-09-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$62.88	$628,780	173,756
2024-09-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$16.65	$166,500	183,756
2024-09-12	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	50,000
2024-09-12	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$59.20	$592,030	676,744
2024-09-12	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	686,744
2024-09-11	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	60,000
2024-09-11	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$59.09	$590,870	676,744
2024-09-11	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	686,744
2024-09-10	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	70,000
2024-09-10	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$59.09	$590,890	676,744
2024-09-10	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	686,744
2024-08-27	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	5,580	$0.00	$0	0
2024-08-27	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	5,580	$18.41	$102,728	173,756
2024-08-21	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	31,861
2024-08-21	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	100	$62.34	$6,234	168,176
2024-08-21	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	9,900	$61.74	$611,236	168,276
2024-08-21	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$16.65	$166,500	178,176
2024-08-20	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	41,861
2024-08-20	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$61.05	$610,550	168,176
2024-08-20	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$16.65	$166,500	178,176
2024-08-15	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	80,000
2024-08-15	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$57.95	$579,490	676,744
2024-08-15	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	686,744
2024-08-14	Posard Matthew L.	—	Open-market sell S	Common Stock	9,881	$57.70	$570,134	69,874
2024-08-14	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	90,000
2024-08-14	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	200	$58.17	$11,634	676,744
2024-08-14	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	6,537	$57.73	$377,394	676,944
2024-08-14	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	3,263	$56.22	$183,443	683,481
2024-08-14	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	686,744
2024-08-13	Posard Matthew L.	—	Open-market sell S	Common Stock	10,000	$56.19	$561,930	79,755
2024-08-13	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	100,000
2024-08-13	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$56.25	$562,490	676,744
2024-08-13	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	686,744
2024-08-12	Posard Matthew L.	—	Open-market sell S	Common Stock	10,000	$55.72	$557,230	89,755
2024-07-24	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	8,285	$0.00	$0	51,861
2024-07-24	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	1,715	$0.00	$0	0
2024-07-24	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$55.12	$551,150	168,176
2024-07-24	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	8,285	$16.65	$137,945	178,176
2024-07-24	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	1,715	$8.11	$13,909	169,891
2024-07-23	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	1,715
2024-07-23	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	5,291	$55.27	$292,407	168,176
2024-07-23	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	4,709	$54.46	$256,466	173,467
2024-07-23	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$8.11	$81,100	178,176
2024-07-22	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	5,000	$0.00	$0	0
2024-07-22	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	992	$54.25	$53,819	15,480
2024-07-22	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	992	$22.50	$22,320	16,472
2024-07-22	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	4,008	$53.85	$215,843	15,480
2024-07-22	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	4,008	$22.50	$90,180	19,488
2024-06-28	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	5,000
2024-06-28	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	10,000	$52.04	$520,400	15,480
2024-06-28	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	10,000	$22.50	$225,000	25,480
2024-06-27	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	15,000
2024-06-27	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	10,000	$51.93	$519,340	15,480
2024-06-27	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	10,000	$22.50	$225,000	25,480
2024-06-26	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	25,000
2024-06-26	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Open-market sell S	Common Stock	10,000	$51.82	$518,200	15,480
2024-06-26	LaBrosse Nicole	SVP, CHIEF FINANCIAL OFFICER	Exercise / conversion M	Common Stock	10,000	$22.50	$225,000	25,480
2024-06-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	11,715
2024-06-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$49.43	$494,260	168,176
2024-06-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$8.11	$81,100	178,176
2024-06-12	Posard Matthew L.	—	Open-market sell S	Common Stock	10,000	$50.62	$506,190	99,755
2024-06-12	Snyder Mark Howard	SVP, CHIEF LEGAL OFFICER	Equity grant / award A · derivative	Restricted Stock Units	20,137	$0.00	$0	20,137
2024-06-11	Posard Matthew L.	—	Open-market sell S	Common Stock	10,000	$50.01	$500,110	109,755
2024-05-22	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	21,715
2024-05-22	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$45.38	$453,840	168,176
2024-05-22	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$8.11	$81,100	178,176
2024-05-21	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	31,715
2024-05-21	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$45.16	$451,640	168,176
2024-05-21	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$8.11	$81,100	178,176
2024-04-25	Posard Matthew L.	—	Equity grant / award A · derivative	Option to Purchase Common Stock	8,804	$0.00	$0	8,804
2024-04-25	Posard Matthew L.	—	Equity grant / award A	Common Stock	6,501	$0.00	$0	119,755
2024-04-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	41,715
2024-04-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$38.49	$384,890	168,176
2024-04-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$8.11	$81,100	178,176
2024-04-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	51,715
2024-04-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$38.35	$383,500	168,176
2024-04-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$8.11	$81,100	178,176
2024-03-26	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	2,890	$0.00	$0	61,715
2024-03-26	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	292	$0.00	$0	0
2024-03-26	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	8,436	$0.00	$0	0
2024-03-26	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	2,890	$8.11	$23,438	168,176
2024-03-26	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	292	$16.78	$4,900	165,286
2024-03-26	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	8,436	$12.07	$101,823	164,994
2024-03-13	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	3,551	$0.00	$0	64,605
2024-03-13	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	6,449	$0.00	$0	8,436
2024-03-13	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$42.27	$422,730	156,558
2024-03-13	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	3,551	$8.11	$28,799	166,558
2024-03-13	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	6,449	$12.07	$77,839	163,007
2024-03-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	14,885
2024-03-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$41.64	$416,370	156,558
2024-03-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$12.07	$120,700	166,558
2024-02-28	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	7,471	$0.00	$0	68,156
2024-02-28	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	7,471	$39.54	$295,418	156,558
2024-02-28	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	7,471	$8.11	$60,590	164,029
2024-02-28	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	2,529	$39.56	$100,045	156,558
2024-02-27	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$39.95	$399,460	159,087
2024-02-23	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Equity grant / award A · derivative	Restricted Stock Units	18,985	$0.00	$0	18,985
2024-02-23	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Equity grant / award A · derivative	Option to Purchase Common Stock	19,674	$0.00	$0	19,674
2024-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	4,264	$0.00	$0	12,789
2024-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	6,112	$0.00	$0	12,224
2024-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	2,160	$36.10	$77,976	169,087
2024-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	4,264	$0.00	$0	171,247
2024-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	3,097	$36.10	$111,802	166,983
2024-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	6,112	$0.00	$0	170,080
2024-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	3,386	$0.00	$0	3,386
2024-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	3,832	$35.91	$137,607	163,968
2024-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Equity grant / award A	Common Stock	8,479	$0.00	$0	167,800
2024-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	1,208	$35.91	$43,379	159,321
2024-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	3,386	$0.00	$0	160,529
2024-02-10	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	8,133	$0.00	$0	0
2024-02-10	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	2,901	$35.49	$102,956	157,143
2024-02-10	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	8,133	$0.00	$0	160,044
2024-01-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	24,885
2024-01-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$36.00	$360,000	151,911
2024-01-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$12.07	$120,700	161,911
2024-01-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	34,885
2024-01-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$36.00	$360,000	151,911
2024-01-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$12.07	$120,700	161,911
2024-01-03	Snyder Mark Howard	SVP, GENERAL COUNSEL	Exercise / conversion M · derivative	Restricted Stock Units	7,611	$0.00	$0	15,222
2024-01-03	Snyder Mark Howard	SVP, GENERAL COUNSEL	Other disposed transaction F	Common Stock	2,957	$35.78	$105,801	9,461
2024-01-03	Snyder Mark Howard	SVP, GENERAL COUNSEL	Exercise / conversion M	Common Stock	7,611	$0.00	$0	12,418
2023-12-13	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	44,885
2023-12-13	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$40.39	$403,940	151,911
2023-12-13	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$12.07	$120,700	161,911
2023-12-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	1,467	$0.00	$0	54,885
2023-12-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	8,533	$0.00	$0	0
2023-12-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	643	$40.47	$26,019	151,911
2023-12-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	9,357	$39.58	$370,303	152,554
2023-12-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	1,467	$12.07	$17,707	161,911
2023-12-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	8,533	$13.81	$117,841	160,444
2023-11-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	8,533
2023-11-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$39.79	$397,880	151,911
2023-11-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$13.81	$138,100	161,911
2023-11-14	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	1,708	$0.00	$0	292
2023-11-14	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	8,292	$0.00	$0	18,533
2023-11-14	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	1,708	$39.08	$66,747	151,911
2023-11-14	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	1,708	$16.78	$28,660	153,619
2023-11-14	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	8,292	$39.08	$324,043	151,911
2023-11-14	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	8,292	$13.81	$114,513	160,203
2023-10-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	41,099
2023-10-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$36.52	$365,200	151,911
2023-10-17	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$19.98	$199,800	161,911
2023-09-19	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	51,099
2023-09-19	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$39.10	$390,980	151,911
2023-09-19	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$19.98	$199,800	161,911
2023-08-31	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	110,000
2023-08-31	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$42.82	$428,170	623,666
2023-08-31	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	633,666
2023-08-30	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	120,000
2023-08-30	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$42.85	$428,540	623,666
2023-08-30	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	633,666
2023-08-29	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	130,000
2023-08-29	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$42.40	$424,020	623,666
2023-08-29	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	633,666
2023-08-22	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	8,075	$0.00	$0	61,099
2023-08-22	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	1,925	$0.00	$0	5,580
2023-08-22	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	8,075	$42.41	$342,437	151,911
2023-08-22	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	8,075	$19.98	$161,338	159,986
2023-08-22	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	1,925	$42.41	$81,633	151,911
2023-08-22	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	1,925	$18.41	$35,439	153,836
2023-08-17	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	140,000
2023-08-17	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$43.18	$431,820	623,666
2023-08-17	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	633,666
2023-08-16	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	150,000
2023-08-16	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$43.53	$435,320	623,666
2023-08-16	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	633,666
2023-08-15	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	160,000
2023-08-15	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$43.77	$437,680	623,666
2023-08-15	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	633,666
2023-08-14	Daly James M	—	Open-market sell S	Common Stock	10,000	$43.74	$437,410	20,503
2023-08-11	Daly James M	—	Open-market sell S	Common Stock	10,000	$43.71	$437,110	30,503
2023-07-27	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	170,000
2023-07-27	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$43.79	$437,900	623,666
2023-07-27	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	633,666
2023-07-26	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	180,000
2023-07-26	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$42.69	$426,890	623,666
2023-07-26	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	633,666
2023-07-25	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$13.87	$138,700	190,000
2023-07-25	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$42.80	$427,960	623,666
2023-07-25	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$13.87	$138,700	633,666
2023-07-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	2,825	$0.00	$0	75,627
2023-07-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	7,175	$0.00	$0	26,825
2023-07-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	7,505
2023-07-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	2,825	$8.11	$22,911	151,911
2023-07-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	7,175	$13.81	$99,087	149,086
2023-07-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$40.43	$404,300	141,911
2023-07-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$18.41	$184,100	151,911
2023-06-21	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	17,505
2023-06-21	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$36.00	$360,000	141,911
2023-06-21	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$18.41	$184,100	151,911
2023-05-05	Posard Matthew L.	—	Equity grant / award A · derivative	Option to Purchase Common Stock	11,371	$0.00	$0	11,371
2023-05-05	Posard Matthew L.	—	Equity grant / award A	Common Stock	8,065	$0.00	$0	113,254
2023-04-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	27,505
2023-04-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$36.00	$360,000	141,911
2023-04-18	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	10,000	$18.41	$184,100	151,911
2023-03-09	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	0
2023-03-09	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$42.73	$427,270	623,666
2023-03-09	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	633,666
2023-03-08	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	10,000
2023-03-08	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$43.26	$432,590	623,666
2023-03-08	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	633,666
2023-03-07	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	20,000
2023-03-07	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$45.47	$454,690	623,666
2023-03-07	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	633,666
2023-03-01	Henderson Jeffrey William	—	Open-market sell S	Common Stock	10,000	$47.71	$477,100	39,045
2023-03-01	Torley Helen	PRESIDENT AND CEO	Equity grant / award G	Common Stock	10,000	$0.00	$0	623,666
2023-02-28	Henderson Jeffrey William	—	Open-market sell S	Common Stock	10,000	$48.51	$485,100	49,045
2023-02-27	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	2,984	$49.55	$147,854	138,927
2023-02-27	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	7,016	$49.55	$347,629	141,911
2023-02-27	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Option to Purchase Common Stock	2,984	$0.00	$0	37,505
2023-02-27	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	2,984	$49.55	$147,854	141,911
2023-02-27	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	2,984	$18.41	$54,935	144,895
2023-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Equity grant / award A · derivative	Restricted Stock Units	17,053	$0.00	$0	17,053
2023-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Equity grant / award A · derivative	Option to Purchase Common Stock	48,849	$0.00	$0	48,849
2023-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	6,112	$0.00	$0	18,336
2023-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	2,878	$49.26	$141,770	148,927
2023-02-16	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	6,112	$0.00	$0	151,805
2023-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	3,386	$0.00	$0	6,772
2023-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	1,170	$49.20	$57,564	145,693
2023-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	3,386	$0.00	$0	146,863
2023-02-15	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Open-market sell S	Common Stock	10,000	$48.39	$483,940	143,477
2023-02-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Unit	7,883	$0.00	$0	0
2023-02-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	2,725	$48.92	$133,307	153,477
2023-02-12	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	7,883	$0.00	$0	156,202
2023-02-10	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M · derivative	Restricted Stock Units	8,133	$0.00	$0	8,133
2023-02-10	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Other disposed transaction F	Common Stock	2,951	$48.92	$144,363	148,319
2023-02-10	LaBarre Michael J.	SVP, CHIEF TECHNICAL OFFICER	Exercise / conversion M	Common Stock	8,133	$0.00	$0	151,270
2023-02-09	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	30,000
2023-02-09	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$50.40	$504,000	587,177
2023-02-09	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2023-02-08	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	40,000
2023-02-08	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$51.36	$513,570	587,177
2023-02-08	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2023-02-07	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	50,000
2023-02-07	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$51.26	$512,580	587,177
2023-02-07	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2023-02-03	Duncan Barbara Gayle	—	Equity grant / award A	Common Stock	1,188	$0.00	$0	1,188
2023-01-19	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	60,000
2023-01-19	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$52.41	$524,140	587,177
2023-01-19	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2023-01-18	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	70,000
2023-01-18	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$51.05	$510,470	587,177
2023-01-18	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2023-01-17	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	80,000
2023-01-17	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	1,103	$50.93	$56,175	587,177
2023-01-17	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	8,897	$50.40	$448,364	588,280
2023-01-17	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2023-01-03	Snyder Mark Howard	SVP, GENERAL COUNSEL	Exercise / conversion M · derivative	Restricted Stock Units	7,611	$0.00	$0	22,833
2023-01-03	Snyder Mark Howard	SVP, GENERAL COUNSEL	Other disposed transaction F	Common Stock	2,804	$55.13	$154,585	4,807
2023-01-03	Snyder Mark Howard	SVP, GENERAL COUNSEL	Exercise / conversion M	Common Stock	7,611	$0.00	$0	7,611
2022-12-15	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	90,000
2022-12-15	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	896	$58.20	$52,145	587,177
2022-12-15	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	9,104	$57.29	$521,550	588,073
2022-12-15	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2022-12-14	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	100,000
2022-12-14	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$58.30	$582,980	587,177
2022-12-14	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2022-12-13	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	110,000
2022-12-13	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	493	$59.12	$29,146	587,177
2022-12-13	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	9,507	$58.64	$557,481	587,670
2022-12-13	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2022-12-06	Posard Matthew L.	—	Open-market sell S	Common Stock	10,000	$56.12	$561,180	105,189
2022-12-05	Posard Matthew L.	—	Open-market sell S	Common Stock	10,000	$55.74	$557,370	115,189
2022-12-02	Posard Matthew L.	—	Open-market sell S	Common Stock	10,000	$58.80	$588,000	125,189
2022-11-17	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	120,000
2022-11-17	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$52.15	$521,490	587,177
2022-11-17	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2022-11-16	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	130,000
2022-11-16	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	10,000	$53.90	$538,990	587,177
2022-11-16	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2022-11-16	MATSUI CONNIE	—	Equity grant / award G	Common Stock	9,250	$0.00	$0	178,939
2022-11-15	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$14.66	$146,600	140,000
2022-11-15	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	13	$54.60	$710	587,177
2022-11-15	Torley Helen	PRESIDENT AND CEO	Open-market sell S	Common Stock	9,987	$54.11	$540,437	587,190
2022-11-15	Torley Helen	PRESIDENT AND CEO	Exercise / conversion M	Common Stock	10,000	$14.66	$146,600	597,177
2022-05-05	Posard Matthew L.	Dir	Equity grant / award A	Restricted Stock Units	6,206	$0.00	$0	135,189
2022-02-16	LaBarre Michael J.	SVP, Chief Technical Officer	Equity grant / award A · derivative	Restricted Stock Units	24,448	$0.00	$0	24,448
2022-02-16	LaBarre Michael J.	SVP, Chief Technical Officer	Equity grant / award A · derivative	Option to Purchase Common Stock	74,777	$0.00	$0	74,777
2022-02-15	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Restricted Stock Units	3,386	$0.00	$0	10,158
2022-02-15	LaBarre Michael J.	SVP, Chief Technical Officer	Other disposed transaction F	Common Stock	1,170	$34.43	$40,283	173,137
2022-02-15	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	3,386	$0.00	$0	174,307
2022-02-14	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Restricted Stock Units	5,771	$0.00	$0	0
2022-02-14	LaBarre Michael J.	SVP, Chief Technical Officer	Other disposed transaction F	Common Stock	1,995	$33.64	$67,112	170,921
2022-02-14	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	5,771	$0.00	$0	172,916
2022-02-12	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Restricted Stock Units	7,883	$0.00	$0	7,883
2022-02-12	LaBarre Michael J.	SVP, Chief Technical Officer	Other disposed transaction F	Common Stock	2,725	$34.20	$93,195	167,145
2022-02-12	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	7,883	$0.00	$0	169,870
2022-02-10	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Restricted Stock Units	8,133	$0.00	$0	16,266
2022-02-10	LaBarre Michael J.	SVP, Chief Technical Officer	Other disposed transaction F	Common Stock	2,992	$34.94	$104,540	161,987
2022-02-10	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	8,133	$0.00	$0	164,979
2022-01-03	Snyder Mark Howard	SVP, General Counsel	Equity grant / award A · derivative	Restricted Stock Unit	30,444	$0.00	$0	30,444
2022-01-03	Snyder Mark Howard	SVP, General Counsel	Equity grant / award A · derivative	Option to Purchase Common Stock	83,142	$0.00	$0	83,142
2021-11-08	Torley Helen	President and CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	50,000	$14.66	$733,000	150,000
2021-11-08	Torley Helen	President and CEO	Open-market sell S	Common Stock	12,225	$40.42	$494,122	537,160
2021-11-08	Torley Helen	President and CEO	Open-market sell S	Common Stock	37,775	$39.62	$1,496,646	549,385
2021-11-08	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	50,000	$14.66	$733,000	587,160
2021-11-05	MATSUI CONNIE	Dir	Open-market sell S	Common Stock	12,548	$40.77	$511,582	181,983
2021-11-05	MATSUI CONNIE	Dir	Open-market sell S	Common Stock	19,452	$40.13	$780,531	194,531
2021-10-12	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Option to Purchase Common Stock	8,050	$0.00	$0	0
2021-10-12	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	8,050	$13.10	$105,455	156,846
2021-10-04	Torley Helen	President and CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	50,000	$14.66	$733,000	200,000
2021-10-04	Torley Helen	President and CEO	Open-market sell S	Common Stock	5,857	$40.95	$239,862	537,160
2021-10-04	Torley Helen	President and CEO	Open-market sell S	Common Stock	44,143	$39.97	$1,764,528	543,017
2021-10-04	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	50,000	$14.66	$733,000	587,160
2021-10-01	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Option to Purchase Common Stock	29,450	$0.00	$0	8,050
2021-10-01	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	29,450	$39.93	$1,175,968	148,796
2021-10-01	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	29,450	$13.10	$385,795	178,246
2021-09-07	Torley Helen	President and CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	50,000	$14.66	$733,000	250,000
2021-09-07	Torley Helen	President and CEO	Open-market sell S	Common Stock	6,560	$42.98	$281,942	537,160
2021-09-07	Torley Helen	President and CEO	Open-market sell S	Common Stock	43,440	$42.29	$1,836,904	543,720
2021-09-07	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	50,000	$14.66	$733,000	587,160
2021-09-04	Matsuda Masaru	SVP, General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	6,883	$0.00	$0	6,883
2021-09-04	Matsuda Masaru	SVP, General Counsel	Other disposed transaction F	Common Stock	3,412	$42.22	$144,055	20,049
2021-09-04	Matsuda Masaru	SVP, General Counsel	Exercise / conversion M	Common Stock	6,883	$0.00	$0	23,461
2021-08-25	BIZZARI JEAN-PIERRE	Dir	Open-market sell S	Common Stock	35,000	$41.01	$1,435,455	52,544
2021-08-10	Torley Helen	President and CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	50,000	$14.66	$733,000	300,000
2021-08-10	Torley Helen	President and CEO	Open-market sell S	Common Stock	1,048	$46.11	$48,323	537,160
2021-08-10	Torley Helen	President and CEO	Open-market sell S	Common Stock	500	$44.91	$22,454	538,208
2021-08-10	Torley Helen	President and CEO	Open-market sell S	Common Stock	400	$43.26	$17,304	538,708
2021-08-10	Torley Helen	President and CEO	Open-market sell S	Common Stock	1,000	$42.64	$42,640	539,108
2021-08-10	Torley Helen	President and CEO	Open-market sell S	Common Stock	21,914	$41.47	$908,752	540,108
2021-08-10	Torley Helen	President and CEO	Open-market sell S	Common Stock	25,138	$40.42	$1,016,103	562,022
2021-08-10	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	50,000	$14.66	$733,000	587,160
2021-07-15	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Option to Purchase Common Stock	14,685	$0.00	$0	0
2021-07-15	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	14,685	$6.55	$96,187	148,796
2021-07-06	Torley Helen	President and CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	50,000	$14.66	$733,000	350,000
2021-07-06	Torley Helen	President and CEO	Open-market sell S	Common Stock	50,000	$45.97	$2,298,650	537,160
2021-07-06	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	50,000	$14.66	$733,000	587,160
2021-07-01	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Option to Purchase Common Stock	40,315	$0.00	$0	14,685
2021-07-01	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	40,315	$45.70	$1,842,315	134,111
2021-07-01	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	40,315	$6.55	$264,063	174,426
2021-06-07	Torley Helen	President and CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	50,000	$14.66	$733,000	400,000
2021-06-07	Torley Helen	President and CEO	Open-market sell S	Common Stock	50,000	$39.66	$1,982,950	537,160
2021-06-07	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	50,000	$14.66	$733,000	587,160
2021-05-11	Torley Helen	President and CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	50,000	$14.66	$733,000	450,000
2021-05-11	Torley Helen	President and CEO	Open-market sell S	Common Stock	1,066	$44.84	$47,803	537,160
2021-05-11	Torley Helen	President and CEO	Open-market sell S	Common Stock	3,956	$44.10	$174,479	538,226
2021-05-11	Torley Helen	President and CEO	Open-market sell S	Common Stock	36,522	$43.05	$1,572,236	542,182
2021-05-11	Torley Helen	President and CEO	Open-market sell S	Common Stock	8,456	$42.17	$356,581	578,704
2021-05-11	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	50,000	$14.66	$733,000	587,160
2021-05-05	Posard Matthew L.	Dir	Equity grant / award A	Restricted Stock Units	5,230	$0.00	$0	128,983
2021-05-03	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Option to Purchase Common Stock	11,311	$0.00	$0	0
2021-05-03	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	11,311	$11.29	$127,701	134,111
2021-04-14	Kelley Kenneth J	Dir	Open-market sell S	Common Stock	5,000	$45.00	$225,000	179,833
2021-04-05	Torley Helen	President and CEO	Exercise / conversion M · derivative	Option to Purchase Common Stock	50,000	$14.66	$733,000	500,000
2021-04-05	Torley Helen	President and CEO	Open-market sell S	Common Stock	50,000	$42.55	$2,127,250	537,160
2021-04-05	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	50,000	$14.66	$733,000	587,160
2021-04-01	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Option to Purchase Common Stock	28,689	$0.00	$0	11,311
2021-04-01	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	18,994	$42.79	$812,829	122,800
2021-04-01	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	9,695	$42.10	$408,208	141,794
2021-04-01	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	28,689	$11.29	$323,899	151,489
2021-03-02	Sun Elaine D	SVP, Chief Financial Officer	Exercise / conversion M · derivative	Restricted Stock Units	12,166	$0.00	$0	36,496
2021-03-02	Sun Elaine D	SVP, Chief Financial Officer	Other disposed transaction F	Common Stock	4,285	$45.01	$192,868	7,881
2021-03-02	Sun Elaine D	SVP, Chief Financial Officer	Exercise / conversion M	Common Stock	12,166	$0.00	$0	12,166
2021-03-01	Kelley Kenneth J	Dir	Open-market sell S	Common Stock	500	$46.08	$23,042	184,833
2021-03-01	Kelley Kenneth J	Dir	Open-market sell S	Common Stock	4,500	$45.26	$203,675	185,333
2021-02-22	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Restricted Stock Units	8,803	$0.00	$0	0
2021-02-22	LaBarre Michael J.	SVP, Chief Technical Officer	Other disposed transaction F	Common Stock	4,364	$48.69	$212,483	141,124
2021-02-22	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	8,803	$0.00	$0	145,488
2021-02-15	Matsuda Masaru	SVP, General Counsel	Equity grant / award A · derivative	Restricted Stock Units	13,544	$0.00	$0	13,544
2021-02-15	Matsuda Masaru	SVP, General Counsel	Equity grant / award A · derivative	Option to Purchase Common Stock	23,311	$0.00	$0	23,311
2021-02-14	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Restricted Stock Units	5,771	$0.00	$0	5,771
2021-02-14	LaBarre Michael J.	SVP, Chief Technical Officer	Other disposed transaction F	Common Stock	2,272	$49.84	$113,236	136,685
2021-02-14	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	5,771	$0.00	$0	138,957
2021-02-12	Matsuda Masaru	SVP, General Counsel	Exercise / conversion M · derivative	Restricted Stock	4,129	$0.00	$0	8,258
2021-02-12	Matsuda Masaru	SVP, General Counsel	Other disposed transaction F	Common Stock	2,047	$49.84	$102,022	16,578
2021-02-12	Matsuda Masaru	SVP, General Counsel	Exercise / conversion M	Common Stock	4,129	$0.00	$0	18,625
2021-02-10	Matsuda Masaru	SVP, General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	6,257	$0.00	$0	18,769
2021-02-10	Matsuda Masaru	SVP, General Counsel	Other disposed transaction F	Common Stock	3,203	$50.60	$162,072	14,496
2021-02-10	Matsuda Masaru	SVP, General Counsel	Exercise / conversion M	Common Stock	6,257	$0.00	$0	17,699
2021-02-01	Kelley Kenneth J	Dir	Open-market sell S	Common Stock	246	$48.69	$11,977	189,833
2021-02-01	Kelley Kenneth J	Dir	Open-market sell S	Common Stock	4,754	$48.09	$228,617	190,079
2021-01-04	Kelley Kenneth J	Dir	Open-market sell S	Common Stock	290	$43.38	$12,581	194,833
2021-01-04	Kelley Kenneth J	Dir	Open-market sell S	Common Stock	4,710	$42.88	$201,974	195,123
2020-12-21	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	600	$43.25	$25,951	122,800
2020-12-21	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	11,400	$42.54	$484,967	123,400
2020-12-07	Kelley Kenneth J	Dir	Open-market sell S	Common Stock	35,086	$41.00	$1,438,526	199,833
2020-12-02	Kelley Kenneth J	Dir	Open-market sell S	Common Stock	31,792	$41.00	$1,303,472	234,919
2020-11-30	Torley Helen	President and CEO	Equity grant / award G	Common Stock	10,000	$0.00	$0	470,522
2020-11-27	Kelley Kenneth J	Dir	Open-market sell S	Common Stock	10,000	$41.25	$412,500	266,711
2020-11-25	Kelley Kenneth J	Dir	Open-market sell S	Common Stock	9,671	$41.50	$401,350	276,711
2020-11-20	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	7,889	$39.04	$307,955	134,800
2020-11-20	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	4,111	$38.24	$157,221	142,689
2020-10-20	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	12,000	$30.43	$365,148	146,800
2020-09-21	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	12,000	$26.91	$322,884	158,800
2020-09-14	MATSUI CONNIE	Dir	Equity grant / award G	Common Stock	8,000	$0.00	$0	208,753
2020-09-11	MATSUI CONNIE	Dir	Open-market sell S	Common Stock	32,000	$27.06	$865,792	216,753
2020-09-04	Matsuda Masaru	SVP, General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	6,884	$0.00	$0	13,766
2020-09-04	Matsuda Masaru	SVP, General Counsel	Other disposed transaction F	Common Stock	2,380	$27.70	$65,926	11,442
2020-09-04	Matsuda Masaru	SVP, General Counsel	Exercise / conversion M	Common Stock	6,884	$0.00	$0	13,822
2020-08-20	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	12,000	$28.30	$339,564	170,800
2020-08-14	Torley Helen	President and CEO	Equity grant / award G	Common Stock	10,000	$0.00	$0	480,522
2020-08-13	Daly James M	Dir	Open-market sell S	Common Stock	34,337	$29.12	$999,893	31,365
2020-07-20	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	12,000	$29.01	$348,072	182,800
2020-05-22	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Option to Purchase Common Stock	18,613	$0.00	$0	0
2020-05-22	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	18,613	$7.14	$132,897	194,800
2020-05-20	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Option to Purchase Common Stock	21,387	$0.00	$0	18,613
2020-05-20	LaBarre Michael J.	SVP, Chief Technical Officer	Open-market sell S	Common Stock	21,387	$23.80	$509,075	176,187
2020-05-20	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	21,387	$7.14	$152,703	197,574
2020-04-30	Posard Matthew L.	Dir	Equity grant / award A	Restricted Stock	8,829	$0.00	$0	123,753
2020-04-01	Sun Elaine D	SVP, Chief Financial Officer	Equity grant / award A · derivative	Performance Stock Units	40,796	$0.00	$0	40,796
2020-03-19	Kelley Kenneth J	Dir	Open-market buy P	Common Stock	17,543	$14.24	$249,781	277,553
2020-03-02	Sun Elaine D	SVP, Chief Financial Officer	Equity grant / award A · derivative	Restricted Stock Units	48,662	$0.00	$0	48,662
2020-03-02	Sun Elaine D	SVP, Chief Financial Officer	Equity grant / award A · derivative	Option to Purchase Common Stock	104,969	$0.00	$0	104,969
2020-02-22	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Restricted Stock Units	8,803	$0.00	$0	8,803
2020-02-22	LaBarre Michael J.	SVP, Chief Technical Officer	Other disposed transaction F	Common Stock	3,044	$21.83	$66,451	176,187
2020-02-22	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	8,803	$0.00	$0	179,231
2020-02-14	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Restricted Stock Units	5,772	$0.00	$0	11,542
2020-02-14	LaBarre Michael J.	SVP, Chief Technical Officer	Other disposed transaction F	Common Stock	1,995	$21.10	$42,094	170,428
2020-02-14	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M	Common Stock	5,772	$0.00	$0	172,423
2020-02-12	Matsuda Masaru	SVP, General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	4,130	$0.00	$0	12,387
2020-02-12	Matsuda Masaru	SVP, General Counsel	Other disposed transaction F	Common Stock	1,681	$20.00	$33,620	6,938
2020-02-12	Matsuda Masaru	SVP, General Counsel	Exercise / conversion M	Common Stock	4,130	$0.00	$0	8,619
2020-02-10	Matsuda Masaru	SVP, General Counsel	Equity grant / award A · derivative	Restricted Stock Units	25,026	$0.00	$0	25,026
2020-02-10	Matsuda Masaru	SVP, General Counsel	Equity grant / award A · derivative	Option to Purchase Common Stock	53,211	$0.00	$0	53,211
2020-02-03	LaBarre Michael J.	SVP, Chief Technical Officer	Other disposed transaction F	Common Stock	4,289	$19.21	$82,392	161,493
2020-02-03	LaBarre Michael J.	SVP, Chief Technical Officer	Exercise / conversion M · derivative	Common Stock	11,559	$0.00	$0	0
2019-10-01	Hickey Benjamin	SVP, Chief Commerical Officer	Exercise / conversion M · derivative	Restricted Stock Units	20,216	$0.00	$0	60,647
2019-10-01	Hickey Benjamin	SVP, Chief Commerical Officer	Other disposed transaction F	Common Stock	6,990	$15.46	$108,065	13,226
2019-10-01	Hickey Benjamin	SVP, Chief Commerical Officer	Exercise / conversion M	Common Stock	20,216	$0.00	$0	20,216
2019-08-03	Chondros Dimitrios	SVP, Chief Medical Officer	Open-market sell S	Common Stock	1,328	$16.70	$22,178	38,584
2019-06-15	Stelzer Laurie	SVP, Chief Financial Officer	Exercise / conversion M · derivative	Restricted Stock Units	6,875	$0.00	$0	0
2019-06-15	Stelzer Laurie	SVP, Chief Financial Officer	Other disposed transaction F	Common Stock	3,408	$15.73	$53,608	81,962
2019-06-15	Stelzer Laurie	SVP, Chief Financial Officer	Exercise / conversion M	Common Stock	6,875	$0.00	$0	85,370
2019-06-03	Armour Alison A.	SVP, Research & Development	Equity grant / award A · derivative	Restricted Stock Units	65,920	$0.00	$0	65,920
2019-06-03	Armour Alison A.	SVP, Research & Development	Equity grant / award A · derivative	Options to Purchase Common Stock	129,358	$0.00	$0	129,358
2019-06-01	Chondros Dimitrios	SVP, Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	2,043	$0.00	$0	4,084
2019-06-01	Chondros Dimitrios	SVP, Chief Medical Officer	Other disposed transaction F	Common Stock	706	$14.75	$10,414	39,912
2019-06-01	Chondros Dimitrios	SVP, Chief Medical Officer	Exercise / conversion M	Common Stock	2,043	$0.00	$0	40,618
2019-05-02	Posard Matthew L.	Dir	Equity grant / award A	Common Stock	12,173	$0.00	$0	114,924
2019-04-13	LEONHARDT HARRY J	SVP, GC	Exercise / conversion M · derivative	Restricted Stock Units	6,875	$0.00	$0	0
2019-04-13	LEONHARDT HARRY J	SVP, GC	Other disposed transaction F	Common Stock	2,377	$16.54	$39,316	66,373
2019-04-13	LEONHARDT HARRY J	SVP, GC	Exercise / conversion M	Common Stock	6,875	$0.00	$0	68,750
2019-02-22	Chondros Dimitrios	SVP, Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	3,884	$0.00	$0	7,767
2019-02-22	Chondros Dimitrios	SVP, Chief Medical Officer	Other disposed transaction F	Common Stock	1,343	$16.81	$22,576	38,575
2019-02-22	Chondros Dimitrios	SVP, Chief Medical Officer	Exercise / conversion M	Common Stock	3,884	$0.00	$0	39,918
2019-02-14	Chondros Dimitrios	SVP, Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	6,790	$0.00	$0	20,370
2019-02-14	Chondros Dimitrios	SVP, Chief Medical Officer	Other disposed transaction F	Common Stock	2,322	$16.54	$38,406	36,067
2019-02-14	Chondros Dimitrios	SVP, Chief Medical Officer	Exercise / conversion M	Common Stock	6,790	$0.00	$0	38,389
2019-02-12	Hickey Benjamin	SVP, Chief Commercial Officer	Equity grant / award A · derivative	Restricted Stock Units	37,538	$0.00	$0	37,538
2019-02-12	Hickey Benjamin	SVP, Chief Commercial Officer	Equity grant / award A · derivative	Options to purchase common stock	71,602	$0.00	$0	71,602
2019-02-06	Torley Helen	President and CEO	Exercise / conversion M · derivative	Restricted Stock Units	31,250	$0.00	$0	0
2019-02-06	Torley Helen	President and CEO	Other disposed transaction F	Common Stock	14,547	$16.73	$243,371	382,251
2019-02-06	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	31,250	$0.00	$0	396,798
2019-02-03	Chondros Dimitrios	SVP, Chief Medical Officer	Other disposed transaction F	Common Stock	2,503	$16.12	$40,348	31,599
2019-02-03	Chondros Dimitrios	SVP, Chief Medical Officer	Open-market sell S	Common Stock	2,536	$16.41	$41,616	31,566
2018-12-07	MATSUI CONNIE	Dir	Equity grant / award G	Common Stock	15,000	$0.00	$0	227,751
2018-10-01	Hickey Benjamin	SVP, Chief Commercial Officer	Equity grant / award A · derivative	Restricted Stock Units	80,863	$0.00	$0	80,863
2018-10-01	Hickey Benjamin	SVP, Chief Commercial Officer	Equity grant / award A · derivative	Options to purchase common stock	149,516	$0.00	$0	149,516
2018-09-07	Connaughton Bernadette	Dir	Equity grant / award A	Common Stock	5,781	$0.00	$0	5,781
2018-08-28	KIRK RANDAL J	10%	Open-market sell S	Common Stock	256,860	$18.02	$4,628,617	1,897,610
2018-08-28	KIRK RANDAL J	10%	Open-market sell S	Common Stock	175,389	$18.02	$3,160,510	3,900,919
2018-08-27	KIRK RANDAL J	10%	Open-market sell S	Common Stock	64,996	$18.22	$1,184,227	2,154,470
2018-08-27	KIRK RANDAL J	10%	Open-market sell S	Common Stock	44,381	$18.22	$808,622	4,076,308
2018-08-24	KIRK RANDAL J	10%	Open-market sell S	Common Stock	61,428	$18.20	$1,117,990	2,219,466
2018-08-24	KIRK RANDAL J	10%	Open-market sell S	Common Stock	41,944	$18.20	$763,381	4,120,689
2018-08-23	KIRK RANDAL J	10%	Open-market sell S	Common Stock	149,353	$18.48	$2,760,043	2,280,894
2018-08-23	KIRK RANDAL J	10%	Open-market sell S	Common Stock	101,982	$18.48	$1,884,627	4,162,633
2018-08-22	KIRK RANDAL J	10%	Open-market sell S	Common Stock	464,624	$17.49	$8,126,274	2,430,247
2018-08-22	KIRK RANDAL J	10%	Open-market sell S	Common Stock	317,257	$17.49	$5,548,825	4,264,615
2018-08-21	KIRK RANDAL J	10%	Open-market sell S	Common Stock	95,819	$17.15	$1,643,296	2,894,871
2018-08-21	KIRK RANDAL J	10%	Open-market sell S	Common Stock	65,427	$17.15	$1,122,073	4,581,872
2018-08-16	KIRK RANDAL J	10%	Open-market sell S	Common Stock	56,668	$17.24	$976,956	2,985,054
2018-08-16	KIRK RANDAL J	10%	Open-market sell S	Common Stock	38,695	$17.24	$667,102	4,643,451
2018-08-15	KIRK RANDAL J	10%	Open-market sell S	Common Stock	54,397	$17.15	$932,909	3,041,722
2018-08-15	KIRK RANDAL J	10%	Open-market sell S	Common Stock	37,144	$17.15	$637,020	4,682,146
2018-08-14	KIRK RANDAL J	10%	Open-market sell S	Common Stock	180,154	$17.36	$3,127,473	3,096,119
2018-08-14	KIRK RANDAL J	10%	Open-market sell S	Common Stock	123,014	$17.36	$2,135,523	4,719,290
2018-08-10	KIRK RANDAL J	10%	Open-market sell S	Common Stock	120,606	$17.08	$2,059,950	3,276,273
2018-08-10	KIRK RANDAL J	10%	Open-market sell S	Common Stock	82,353	$17.08	$1,406,589	4,842,304
2018-08-09	KIRK RANDAL J	10%	Open-market sell S	Common Stock	132,591	$17.48	$2,317,691	3,396,879
2018-08-09	KIRK RANDAL J	10%	Open-market sell S	Common Stock	90,536	$17.48	$1,582,569	4,924,657
2018-08-08	KIRK RANDAL J	10%	Open-market sell S	Common Stock	87,185	$17.52	$1,527,481	3,529,470
2018-08-08	KIRK RANDAL J	10%	Open-market sell S	Common Stock	59,533	$17.52	$1,043,018	5,015,193
2018-08-03	Chondros Dimitrios	SVP, Chief Medical Officer	Other disposed transaction F	Common Stock	1,305	$17.08	$22,289	34,102
2018-07-27	KIRK RANDAL J	10%	Open-market sell S	Common Stock	29,074	$16.90	$491,351	3,616,655
2018-07-27	KIRK RANDAL J	10%	Open-market sell S	Common Stock	19,853	$16.90	$335,516	5,074,726
2018-07-26	KIRK RANDAL J	10%	Open-market sell S	Common Stock	89,136	$17.30	$1,542,053	3,645,729
2018-07-26	KIRK RANDAL J	10%	Open-market sell S	Common Stock	60,864	$17.30	$1,052,947	5,094,579
2018-07-25	KIRK RANDAL J	10%	Open-market sell S	Common Stock	61,741	$17.32	$1,069,354	3,734,865
2018-07-25	KIRK RANDAL J	10%	Open-market sell S	Common Stock	42,159	$17.32	$730,194	5,155,443
2018-06-29	KIRK RANDAL J	10%	Open-market sell S	Common Stock	72,753	$16.97	$1,234,618	3,796,606
2018-06-29	KIRK RANDAL J	10%	Open-market sell S	Common Stock	49,678	$16.97	$843,036	5,197,602
2018-06-28	KIRK RANDAL J	10%	Open-market sell S	Common Stock	76,291	$16.99	$1,296,184	3,869,359
2018-06-28	KIRK RANDAL J	10%	Open-market sell S	Common Stock	52,094	$16.99	$885,077	5,247,280
2018-06-27	KIRK RANDAL J	10%	Open-market sell S	Common Stock	31,795	$17.34	$551,325	3,945,650
2018-06-27	KIRK RANDAL J	10%	Open-market sell S	Common Stock	21,710	$17.34	$376,451	5,299,374
2018-06-15	Stelzer Laurie	SVP, Chief Financial Officer	Exercise / conversion M · derivative	Restricted Stock Units	6,875	$0.00	$0	6,875
2018-06-15	Stelzer Laurie	SVP, Chief Financial Officer	Other disposed transaction F	Common Stock	3,254	$19.02	$61,891	51,131
2018-06-15	Stelzer Laurie	SVP, Chief Financial Officer	Exercise / conversion M	Common Stock	6,875	$0.00	$0	54,385
2018-06-01	Chondros Dimitrios	SVP, Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	2,043	$0.00	$0	6,127
2018-06-01	Chondros Dimitrios	SVP, Chief Medical Officer	Other disposed transaction F	Common Stock	712	$18.59	$13,236	35,407
2018-06-01	Chondros Dimitrios	SVP, Chief Medical Officer	Exercise / conversion M	Common Stock	2,043	$0.00	$0	36,119
2018-05-02	Posard Matthew L.	Dir	Equity grant / award A	Common Stock	10,363	$0.00	$0	102,751
2018-04-13	LEONHARDT HARRY J	SVP, GC and CCO	Exercise / conversion M · derivative	Restricted Stock Units	6,875	$0.00	$0	6,875
2018-04-13	LEONHARDT HARRY J	SVP, GC and CCO	Other disposed transaction F	Common Stock	2,377	$19.37	$46,042	39,558
2018-04-13	LEONHARDT HARRY J	SVP, GC and CCO	Exercise / conversion M	Common Stock	6,875	$0.00	$0	41,935
2018-02-22	LEONHARDT HARRY J	SVP, GC and CCO	Exercise / conversion M · derivative	Restricted Stock Units	11,392	$0.00	$0	34,176
2018-02-22	LEONHARDT HARRY J	SVP, GC and CCO	Other disposed transaction F	Common Stock	3,939	$19.28	$75,944	35,060
2018-02-22	LEONHARDT HARRY J	SVP, GC and CCO	Exercise / conversion M	Common Stock	11,392	$0.00	$0	38,999
2018-02-14	LEONHARDT HARRY J	SVP, GC and CCO	Equity grant / award A · derivative	Restricted Stock Units	31,234	$0.00	$0	31,234
2018-02-14	LEONHARDT HARRY J	SVP, GC and CCO	Equity grant / award A · derivative	Option to Purchase Common Stock	54,780	$0.00	$0	54,780
2018-02-06	Torley Helen	President and CEO	Exercise / conversion M · derivative	Restricted Stock Units	31,250	$0.00	$0	31,250
2018-02-06	Torley Helen	President and CEO	Other disposed transaction F	Common Stock	15,493	$18.25	$282,747	309,643
2018-02-06	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	31,250	$0.00	$0	325,136
2018-02-03	LEONHARDT HARRY J	SVP, GC and CCO	Exercise / conversion M · derivative	Restricted Stock Units	15,413	$0.00	$0	30,826
2018-02-03	LEONHARDT HARRY J	SVP, GC and CCO	Other disposed transaction F	Common Stock	5,605	$18.37	$102,964	27,607
2018-02-03	LEONHARDT HARRY J	SVP, GC and CCO	Exercise / conversion M	Common Stock	15,413	$0.00	$0	33,212
2018-01-06	Torley Helen	President and CEO	Exercise / conversion M · derivative	Restricted Stock Units	30,000	$0.00	$0	0
2018-01-06	Torley Helen	President and CEO	Other disposed transaction F	Common Stock	11,649	$19.46	$226,690	262,510
2018-01-06	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	30,000	$0.00	$0	274,159
2017-09-21	MATSUI CONNIE	Dir	Equity grant / award G	Common Stock	15,000	$0.00	$0	232,388
2017-07-24	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	2,327,603	$0.00	$0	2,327,603
2017-07-24	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	2,264,483	$0.00	$0	5,321,084
2017-07-24	KIRK RANDAL J	Dir	Other disposed transaction J	Common Stock	6,328,853	$0.00	$0	0
2017-06-15	Stelzer Laurie	SVP, Chief Financial Officer	Exercise / conversion M · derivative	Restricted Stock Units	6,875	$0.00	$0	13,750
2017-06-15	Stelzer Laurie	SVP, Chief Financial Officer	Other disposed transaction F	Common Stock	2,583	$13.05	$33,708	25,202
2017-06-15	Stelzer Laurie	SVP, Chief Financial Officer	Exercise / conversion M	Common Stock	6,875	$0.00	$0	27,785
2017-05-11	KIRK RANDAL J	Dir	Exercise / conversion M · derivative	Option to Purchase Common Stock	10,000	$0.00	$0	0
2017-05-11	KIRK RANDAL J	Dir	Exercise / conversion M	Common Stock	10,000	$10.37	$103,700	3,562,388
2017-05-08	MATSUI CONNIE	Dir	Exercise / conversion M · derivative	Options to Purchase Common Stock	10,000	$0.00	$0	0
2017-05-08	MATSUI CONNIE	Dir	Exercise / conversion M	Common Stock	10,000	$10.37	$103,700	247,388
2017-05-04	KIRK RANDAL J	Dir	Equity grant / award A	Common Stock	14,135	$0.00	$0	3,552,388
2017-04-13	LEONHARDT HARRY J	SVP, GC and CCO	Exercise / conversion M · derivative	Restricted Stock Units	6,875	$0.00	$0	13,750
2017-04-13	LEONHARDT HARRY J	SVP, GC and CCO	Other disposed transaction F	Common Stock	2,583	$12.81	$33,088	17,799
2017-04-13	LEONHARDT HARRY J	SVP, GC and CCO	Exercise / conversion M	Common Stock	6,875	$0.00	$0	20,382
2017-02-22	LEONHARDT HARRY J	SVP, GC and CCO	Equity grant / award A · derivative	Restricted Stock Units	45,568	$0.00	$0	45,568
2017-02-22	LEONHARDT HARRY J	SVP, GC and CCO	Equity grant / award A · derivative	Option to Purchase Common Stock	72,925	$0.00	$0	72,925
2017-02-06	Torley Helen	President and CEO	Exercise / conversion M · derivative	Restricted Stock Units	31,250	$0.00	$0	62,500
2017-02-06	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	31,250	$0.00	$0	244,159
2017-02-03	LEONHARDT HARRY J	SVP, GC and CCO	Exercise / conversion M · derivative	Restricted Stock Units	15,413	$0.00	$0	46,239
2017-02-03	LEONHARDT HARRY J	SVP, GC and CCO	Other disposed transaction F	Common Stock	6,198	$12.26	$75,987	13,507
2017-02-03	LEONHARDT HARRY J	SVP, GC and CCO	Exercise / conversion M	Common Stock	15,413	$0.00	$0	19,705
2017-01-06	Torley Helen	President and CEO	Exercise / conversion M · derivative	Restricted Stock Units	30,000	$0.00	$0	30,000
2017-01-06	Torley Helen	President and CEO	Exercise / conversion M	Common Stock	30,000	$0.00	$0	157,422
2017-01-05	Countouriotis Athena	SVP and Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	7,500	$0.00	$0	15,000
2017-01-05	Countouriotis Athena	SVP and Chief Medical Officer	Exercise / conversion M	Common Stock	7,500	$0.00	$0	27,481
2016-09-01	Gergen Mark J	SVP, Chief Operating Officer	Equity grant / award A · derivative	Options to Purchase Common Stock	333,890	$0.00	$0	333,890
2016-06-30	Countouriotis Athena	SVP and Chief Medical Officer	Exercise / conversion M · derivative	Performance Stock Units	6,450	—	$0	0
2016-06-30	Countouriotis Athena	SVP and Chief Medical Officer	Equity grant / award A · derivative	Performance Stock Units	6,450	—	$0	6,450
2016-06-30	Countouriotis Athena	SVP and Chief Medical Officer	Other disposed transaction F	Common Stock	107	$8.63	$923	19,981
2016-06-30	Countouriotis Athena	SVP and Chief Medical Officer	Exercise / conversion M	Common Stock	6,450	$0.00	$0	20,088
2016-06-15	Stelzer Laurie	SVP, Chief Financial Officer	Exercise / conversion M · derivative	Restricted Stock Units	6,875	$0.00	$0	20,625
2016-06-15	Stelzer Laurie	SVP, Chief Financial Officer	Exercise / conversion M	Common Stock	6,875	$0.00	$0	16,875
2016-05-31	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	21,858	—	—	21,858
2016-05-31	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	65,572	—	—	65,572
2016-05-31	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	131,144	—	—	131,144
2016-05-31	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	4,382	—	—	46,701
2016-05-31	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	27,260	—	—	290,460
2016-05-31	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	2,235	—	—	2,235
2016-05-31	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	23,259	—	—	354,653
2016-05-31	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	9,954	—	—	302,954
2016-05-31	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	372	—	—	11,317
2016-05-31	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	371,186	—	—	3,056,601
2016-05-31	KIRK RANDAL J	Dir	Other acquired transaction J	Common Stock	81,795	—	—	216,795
2016-05-31	KIRK RANDAL J	Dir	Other disposed transaction J	Common Stock	1,326,320	—	—	0
2016-05-04	Posard Matthew L.	Dir	Equity grant / award A	Common Stock	20,202	$0.00	$0	78,253

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count