Financial Metrics

INCY INCYTE CORP

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	0.12	—	USD/shares	10-Q	2017-05-04
Quarterly	2016-06-30	0.18	+50.0%	USD/shares	10-Q	2017-08-01
Quarterly	2016-09-30	0.19	+5.6%	USD/shares	10-Q	2017-10-31
Quarterly	2017-03-31	-0.96	-605.3%	USD/shares	10-Q	2017-05-04
Quarterly	2017-06-30	-0.06	+93.7%	USD/shares	10-Q	2018-07-31
Quarterly	2017-09-30	0.17	+383.3%	USD/shares	10-Q	2018-10-30
Quarterly	2018-03-31	-0.19	-211.8%	USD/shares	10-Q	2019-04-30
Quarterly	2018-06-30	0.24	+226.3%	USD/shares	10-Q	2019-07-30
Quarterly	2018-09-30	0.14	-41.7%	USD/shares	10-Q	2019-10-29
Quarterly	2019-03-31	0.47	+235.7%	USD/shares	10-Q	2020-05-05
Quarterly	2019-06-30	0.48	+2.1%	USD/shares	10-Q	2020-08-04
Quarterly	2019-09-30	0.59	+22.9%	USD/shares	10-Q	2020-11-05
Quarterly	2020-03-31	-3.33	-664.4%	USD/shares	10-Q	2021-05-04
Quarterly	2020-06-30	1.32	+139.6%	USD/shares	10-Q	2021-08-03
Quarterly	2020-09-30	-0.07	-105.3%	USD/shares	10-Q	2021-11-02
Quarterly	2021-03-31	0.24	+442.9%	USD/shares	10-Q	2022-05-03
Quarterly	2021-06-30	0.67	+179.2%	USD/shares	10-Q	2022-08-02
Quarterly	2021-09-30	0.82	+22.4%	USD/shares	10-Q	2022-11-01
Quarterly	2022-03-31	0.17	-79.3%	USD/shares	10-Q	2023-05-02
Quarterly	2022-06-30	0.72	+323.5%	USD/shares	10-Q	2023-08-01
Quarterly	2022-09-30	0.5	-30.6%	USD/shares	10-Q	2023-10-31
Quarterly	2023-03-31	0.1	-80.0%	USD/shares	10-Q	2024-04-30
Quarterly	2023-06-30	0.9	+800.0%	USD/shares	10-Q	2024-07-30
Quarterly	2023-09-30	0.76	-15.6%	USD/shares	10-Q	2024-10-29
Quarterly	2024-03-31	0.75	-1.3%	USD/shares	10-Q	2025-04-29
Quarterly	2024-06-30	-2.04	-372.0%	USD/shares	10-Q	2025-07-29
Quarterly	2024-09-30	0.54	+126.5%	USD/shares	10-Q	2025-10-28
Quarterly	2025-03-31	0.8	+48.1%	USD/shares	10-Q	2025-04-29
Quarterly	2025-06-30	2.04	+155.0%	USD/shares	10-Q	2025-07-29
Quarterly	2025-09-30	2.11	+3.4%	USD/shares	10-Q	2025-10-28
Annual	2016-12-31	0.54	—	USD/shares	10-K	2019-02-14
Annual	2017-12-31	-1.53	-383.3%	USD/shares	10-K	2020-02-13
Annual	2018-12-31	0.51	+133.3%	USD/shares	10-K	2021-02-09
Annual	2019-12-31	2.05	+302.0%	USD/shares	10-K	2022-02-08
Annual	2020-12-31	-1.36	-166.3%	USD/shares	10-K	2023-02-07
Annual	2021-12-31	4.27	+414.0%	USD/shares	10-K	2024-02-13
Annual	2022-12-31	1.52	-64.4%	USD/shares	10-K	2025-02-10
Annual	2023-12-31	2.65	+74.3%	USD/shares	10-K	2026-02-10
Annual	2024-12-31	0.15	-94.3%	USD/shares	10-K	2026-02-10
Annual	2025-12-31	6.41	+4173.3%	USD/shares	10-K	2026-02-10

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Annual	2016-12-31	749800000.0	—	USD	10-K	2017-02-14
Annual	2017-12-31	26800000.0	-96.4%	USD	10-K	2018-02-15
Annual	2018-12-31	19094000000.0	+71146.3%	USD	10-K	2019-02-14

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2024-05-31	48700000.0	—	USD	10-Q	2025-10-28
Annual	2024-05-31	48700000.0	—	USD	10-K	2026-02-10

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	192625000.0	—	shares	10-Q	2017-05-04
Quarterly	2016-06-30	193015000.0	+0.2%	shares	10-Q	2017-08-01
Quarterly	2016-09-30	194265000.0	+0.6%	shares	10-Q	2017-10-31
Quarterly	2017-03-31	195260000.0	+0.5%	shares	10-Q	2018-05-01
Quarterly	2017-06-30	205141000.0	+5.1%	shares	10-Q	2018-07-31
Quarterly	2017-09-30	212610000.0	+3.6%	shares	10-Q	2018-10-30
Quarterly	2018-03-31	211681000.0	-0.4%	shares	10-Q	2019-04-30
Quarterly	2018-06-30	215103000.0	+1.6%	shares	10-Q	2019-07-30
Quarterly	2018-09-30	215964000.0	+0.4%	shares	10-Q	2019-10-29
Quarterly	2019-03-31	217061000.0	+0.5%	shares	10-Q	2020-05-05
Quarterly	2019-06-30	217483000.0	+0.2%	shares	10-Q	2020-08-04
Quarterly	2019-09-30	217791000.0	+0.1%	shares	10-Q	2020-11-05
Quarterly	2020-03-31	216721000.0	-0.5%	shares	10-Q	2021-05-04
Quarterly	2020-06-30	220434000.0	+1.7%	shares	10-Q	2021-08-03
Quarterly	2020-09-30	218784000.0	-0.7%	shares	10-Q	2021-11-02
Quarterly	2021-03-31	221867000.0	+1.4%	shares	10-Q	2022-05-03
Quarterly	2021-06-30	222250000.0	+0.2%	shares	10-Q	2022-08-02
Quarterly	2021-09-30	222248000.0	-0.0%	shares	10-Q	2022-11-01
Quarterly	2022-03-31	222950000.0	+0.3%	shares	10-Q	2023-05-02
Quarterly	2022-06-30	223661000.0	+0.3%	shares	10-Q	2023-08-01
Quarterly	2022-09-30	224175000.0	+0.2%	shares	10-Q	2023-10-31
Quarterly	2023-03-31	225589000.0	+0.6%	shares	10-Q	2024-04-30
Quarterly	2023-06-30	225649000.0	+0.0%	shares	10-Q	2024-07-30
Quarterly	2023-09-30	226167000.0	+0.2%	shares	10-Q	2024-10-29
Quarterly	2024-03-31	227219000.0	+0.5%	shares	10-Q	2025-04-29
Quarterly	2024-06-30	218175000.0	-4.0%	shares	10-Q	2025-07-29
Quarterly	2024-09-30	195838000.0	-10.2%	shares	10-Q	2025-10-28
Quarterly	2025-03-31	198197000.0	+1.2%	shares	10-Q	2025-04-29
Quarterly	2025-06-30	198744000.0	+0.3%	shares	10-Q	2025-07-29
Quarterly	2025-09-30	201429000.0	+1.4%	shares	10-Q	2025-10-28
Annual	2016-12-31	194125000.0	—	shares	10-K	2019-02-14
Annual	2017-12-31	204580000.0	+5.4%	shares	10-K	2020-02-13
Annual	2018-12-31	215635000.0	+5.4%	shares	10-K	2021-02-09
Annual	2019-12-31	217657000.0	+0.9%	shares	10-K	2022-02-08
Annual	2020-12-31	218073000.0	+0.2%	shares	10-K	2023-02-07
Annual	2021-12-31	222074000.0	+1.8%	shares	10-K	2024-02-13
Annual	2022-12-31	223958000.0	+0.8%	shares	10-K	2025-02-10
Annual	2023-12-31	225928000.0	+0.9%	shares	10-K	2026-02-10
Annual	2024-12-31	210530000.0	-6.8%	shares	10-K	2026-02-10
Annual	2025-12-31	200700000.0	-4.7%	shares	10-K	2026-02-10

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

19,094,000,000

Total Liabilities (latest annual)

1,790,495,000

Current Liabilities (latest annual)

1,515,170,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2017-03-31	-0.1937	—	ratio	10-Q	2018-05-01
Quarterly	2017-06-30	-0.1944	-0.3%	ratio	10-Q	2018-07-31
Quarterly	2017-09-30	-0.0930	+52.1%	ratio	10-Q	2018-10-30
Quarterly	2018-03-31	-0.0253	+72.8%	ratio	10-Q	2019-10-29
Quarterly	2018-06-30	0.0302	+219.6%	ratio	10-Q	2019-10-29
Quarterly	2018-09-30	0.0224	-25.8%	ratio	10-Q	2019-10-29
Quarterly	2019-03-31	0.0491	+118.8%	ratio	10-Q	2020-11-05
Quarterly	2019-06-30	0.0469	-4.5%	ratio	10-Q	2020-11-05
Quarterly	2019-09-30	0.1387	+195.9%	ratio	10-Q	2020-11-05
Quarterly	2020-03-31	-0.3719	-368.2%	ratio	10-Q	2021-11-02
Quarterly	2020-06-30	0.1238	+133.3%	ratio	10-Q	2021-11-02
Quarterly	2020-09-30	-0.1864	-250.5%	ratio	10-Q	2021-11-02
Quarterly	2021-03-31	0.0196	+110.5%	ratio	10-Q	2022-11-01
Quarterly	2021-06-30	0.0509	+159.4%	ratio	10-Q	2022-11-01
Quarterly	2021-09-30	0.1222	+140.0%	ratio	10-Q	2022-11-01
Quarterly	2022-03-31	0.0098	-92.0%	ratio	10-Q	2023-10-31
Quarterly	2022-06-30	0.0395	+301.8%	ratio	10-Q	2023-10-31
Quarterly	2022-09-30	0.0739	+86.9%	ratio	10-Q	2023-10-31
Quarterly	2023-03-31	0.0049	-93.4%	ratio	10-Q	2024-10-29
Quarterly	2023-06-30	0.0429	+782.9%	ratio	10-Q	2024-10-29
Quarterly	2023-09-30	0.0804	+87.3%	ratio	10-Q	2024-10-29
Quarterly	2024-03-31	0.0314	-60.9%	ratio	10-Q	2025-10-28
Quarterly	2024-06-30	-0.1483	-572.0%	ratio	10-Q	2025-10-28
Quarterly	2024-09-30	-0.0532	+64.2%	ratio	10-Q	2025-10-28
Quarterly	2025-03-31	0.0431	+181.1%	ratio	10-Q	2025-10-28
Quarterly	2025-06-30	0.0971	+125.1%	ratio	10-Q	2025-10-28
Quarterly	2025-09-30	0.2123	+118.6%	ratio	10-Q	2025-10-28
Annual	2016-12-31	0.2485	—	ratio	10-K	2019-02-14
Annual	2017-12-31	-0.1920	-177.3%	ratio	10-K	2020-02-13
Annual	2018-12-31	0.0569	+129.6%	ratio	10-K	2021-02-09
Annual	2019-12-31	0.1720	+202.5%	ratio	10-K	2022-02-08
Annual	2020-12-31	-0.1132	-165.8%	ratio	10-K	2023-02-07
Annual	2021-12-31	0.2516	+322.2%	ratio	10-K	2024-02-13
Annual	2022-12-31	0.0780	-69.0%	ratio	10-K	2025-02-10
Annual	2023-12-31	0.1151	+47.7%	ratio	10-K	2026-02-10
Annual	2024-12-31	0.0095	-91.8%	ratio	10-K	2026-02-10
Annual	2025-12-31	0.2490	+2532.0%	ratio	10-K	2026-02-10

8-K Material Event Details

45 filings · 80 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

653 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-03-31	BAKER BROS. ADVISORS LP	—	Equity grant / award A	Common Stock	421	$0.00	$0	28,188,718
2026-03-25	Trotta Matteo	EVP, GM, Dermatology US	Other disposed transaction F	Common Stock	537	$92.23	$49,528	14,882
2026-03-17	CAGNONI PABLO J	President, R&D	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	11,501	$0.00	$0	32,910
2026-03-17	CAGNONI PABLO J	President, R&D	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	7,166	$0.00	$0	9,102
2026-03-17	CAGNONI PABLO J	President, R&D	Open-market sell S	Common Stock	18,667	$94.24	$1,759,178	234,800
2026-03-17	CAGNONI PABLO J	President, R&D	Exercise / conversion M	Common Stock	11,501	$64.25	$738,939	253,467
2026-03-17	CAGNONI PABLO J	President, R&D	Exercise / conversion M	Common Stock	7,166	$61.18	$438,416	241,966
2026-02-19	CAGNONI PABLO J	President, R&D	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	5,575	$0.00	$0	16,268
2026-02-19	CAGNONI PABLO J	President, R&D	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	13,093	$0.00	$0	7,182
2026-02-19	CAGNONI PABLO J	President, R&D	Open-market sell S	Common Stock	18,668	$100.91	$1,883,788	234,800
2026-02-19	CAGNONI PABLO J	President, R&D	Exercise / conversion M	Common Stock	5,575	$61.18	$341,078	253,468
2026-02-19	CAGNONI PABLO J	President, R&D	Exercise / conversion M	Common Stock	13,093	$61.76	$808,624	247,893
2026-02-02	Morrissey Michael James	EVP, Head of Tech. Operations	Other disposed transaction F	Common Stock	185	$102.67	$18,994	34,065
2026-01-16	Heeson Lee	EVP, Head of Incyte Intl	Equity grant / award A	Common Stock	8,911	$0.00	$0	38,152
2026-01-07	Issa Mohamed Khairie	EVP, Head of US Oncology	Open-market sell S	Common Stock	10,856	$109.07	$1,184,064	66,132
2026-01-06	Issa Mohamed Khairie	EVP, Head of US Oncology	Other disposed transaction F	Common Stock	8,264	$106.66	$881,438	76,988
2026-01-05	Stein Steven H	EVP & Chief Medical Officer	Open-market sell S	Common Stock	15,634	$101.70	$1,589,978	34,203
2025-12-31	Clancy Paul J	Dir	Equity grant / award A	Common Stock	241	$98.77	$23,804	23,476
2025-12-19	Tray Thomas	Principal Accounting Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,730	$0.00	$0	0
2025-12-19	Tray Thomas	Principal Accounting Officer	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,044	$0.00	$0	0
2025-12-19	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	2,774	$100.00	$277,400	22,973
2025-12-19	Tray Thomas	Principal Accounting Officer	Exercise / conversion M	Common Stock	1,730	$95.76	$165,665	25,747
2025-12-19	Tray Thomas	Principal Accounting Officer	Exercise / conversion M	Common Stock	1,044	$95.76	$99,973	24,017
2025-12-18	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	600	$98.25	$58,950	22,973
2025-12-17	Morrissey Michael James	EVP, Head of Tech. Operations	Open-market sell S	Common Stock	4,323	$97.26	$420,455	27,507
2025-12-16	Morrissey Michael James	EVP, Head of Tech. Operations	Open-market sell S	Common Stock	53,175	$97.29	$5,173,396	31,830
2025-12-16	Morrissey Michael James	EVP, Head of Tech. Operations	Open-market sell S	Common Stock	833	$97.42	$81,151	85,005
2025-12-11	Mayes Patrick A	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	255	$94.94	$24,210	60,011
2025-12-10	Mayes Patrick A	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	5,553	$95.58	$530,756	60,266
2025-12-08	Hoppenot Herve	Dir	Other disposed transaction F	Common Stock	2,843	$96.70	$274,918	326,803
2025-12-02	Stein Steven H	EVP & Chief Medical Officer	Open-market sell S	Common Stock	20,105	$102.51	$2,060,964	63,129
2025-12-01	Stein Steven H	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	17,093	$102.04	$1,744,170	83,234
2025-12-01	Stein Steven H	EVP & Chief Medical Officer	Open-market sell S	Common Stock	2,559	$102.96	$263,475	100,327
2025-11-24	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	600	$103.00	$61,800	23,573
2025-11-21	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	169	$102.00	$17,238	24,173
2025-11-17	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	278	$0.00	$0	8,883
2025-11-17	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	278	$104.36	$29,012	26,569
2025-11-17	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	278	$64.25	$17,862	26,847
2025-11-10	Hoppenot Herve	Dir	Open-market sell S	Common Stock	187,500	$105.46	$19,773,750	329,646
2025-11-05	Stein Steven H	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,044	$0.00	$0	0
2025-11-05	Stein Steven H	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,995	$0.00	$0	0
2025-11-05	Stein Steven H	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,194	$0.00	$0	0
2025-11-05	Stein Steven H	EVP & Chief Medical Officer	Open-market sell S	Common Stock	5,233	$102.20	$534,813	102,886
2025-11-05	Stein Steven H	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	1,044	$95.76	$99,973	108,119
2025-11-05	Stein Steven H	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	2,995	$95.76	$286,801	107,075
2025-11-05	Stein Steven H	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	1,194	$83.83	$100,093	104,080
2025-11-04	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	598	$0.00	$0	13,765
2025-11-04	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	598	$101.36	$60,613	26,569
2025-11-04	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	598	$58.06	$34,720	27,167
2025-11-03	Heeson Lee	EVP, Head of Incyte Intl	Open-market sell S	Common Stock	3,074	$94.02	$289,017	29,241
2025-10-15	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	277	$0.00	$0	9,161
2025-10-15	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	277	$85.13	$23,581	26,569
2025-10-15	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	277	$64.25	$17,797	26,846
2025-10-03	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	3,501	$85.54	$299,476	26,569
2025-10-02	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	599	$0.00	$0	14,363
2025-10-02	Denton Sheila A.	EVP & General Counsel	Other disposed transaction F	Common Stock	3,130	$86.28	$270,056	30,070
2025-10-02	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	599	$87.65	$52,502	33,200
2025-10-02	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	599	$58.06	$34,778	33,799
2025-10-01	Mayes Patrick A	EVP & Chief Scientific Officer	Other disposed transaction F	Common Stock	1,569	$86.70	$136,032	65,819
2025-09-30	BAKER BROS. ADVISORS LP	—	Equity grant / award A	Common Stock	388	$0.00	$0	28,187,969
2025-09-22	Gardner David H	EVP, Chief Strategy Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	42,899	$0.00	$0	42,899
2025-09-22	Gardner David H	EVP, Chief Strategy Officer	Equity grant / award A · derivative	Performance Shares	23,573	$0.00	$0	23,573
2025-09-22	Gardner David H	EVP, Chief Strategy Officer	Equity grant / award A	Common Stock	9,429	$0.00	$0	9,429
2025-09-16	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	278	$0.00	$0	9,438
2025-09-16	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	278	$83.15	$23,116	33,200
2025-09-16	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	278	$64.25	$17,862	33,478
2025-09-02	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	598	$0.00	$0	14,962
2025-09-02	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	598	$84.97	$50,812	33,200
2025-09-02	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	598	$58.06	$34,720	33,798
2025-08-25	Basi Ramitpal K	EVP, Human Resources	Equity grant / award A · derivative	Employee Stock Option (right to buy)	29,230	$0.00	$0	29,230
2025-08-25	Basi Ramitpal K	EVP, Human Resources	Equity grant / award A · derivative	Performance Shares	16,265	$0.00	$0	16,265
2025-08-25	Basi Ramitpal K	EVP, Human Resources	Equity grant / award A	Common Stock	6,506	$0.00	$0	6,506
2025-08-15	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	277	$0.00	$0	9,716
2025-08-15	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	277	$86.81	$24,046	33,200
2025-08-15	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	277	$64.25	$17,797	33,477
2025-08-04	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	598	$0.00	$0	15,560
2025-08-04	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	598	$75.77	$45,310	33,200
2025-08-04	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	598	$58.06	$34,720	33,798
2025-07-21	Stein Steven H	EVP & Chief Medical Officer	Open-market sell S	Common Stock	3,706	$67.94	$251,786	102,886
2025-07-16	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	785	$68.36	$53,663	33,200
2025-07-16	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	1,340	$68.36	$91,602	35,149
2025-07-15	CAGNONI PABLO J	President, R&D	Equity grant / award A · derivative	Employee Stock Option (right to buy)	39,471	$0.00	$0	39,471
2025-07-15	CAGNONI PABLO J	President, R&D	Equity grant / award A · derivative	Performance Shares	43,846	$0.00	$0	43,846
2025-07-15	CAGNONI PABLO J	President, R&D	Equity grant / award A	Common Stock	17,538	$0.00	$0	234,800
2025-07-15	CAGNONI PABLO J	President, R&D	Other disposed transaction F	Common Stock	2,628	$68.25	$179,361	217,262
2025-07-15	Denton Sheila A.	EVP & General Counsel	Equity grant / award A · derivative	Employee Stock Option (right to buy)	18,419	$0.00	$0	18,419
2025-07-15	Denton Sheila A.	EVP & General Counsel	Equity grant / award A · derivative	Performance Shares	20,461	$0.00	$0	20,461
2025-07-15	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	3,330	$0.00	$0	9,993
2025-07-15	Denton Sheila A.	EVP & General Counsel	Equity grant / award A	Common Stock	8,184	$0.00	$0	33,985
2025-07-15	Denton Sheila A.	EVP & General Counsel	Other disposed transaction F	Common Stock	703	$68.25	$47,980	25,801
2025-07-15	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	3,330	$69.86	$232,634	26,504
2025-07-15	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	3,330	$64.25	$213,952	29,834
2025-07-14	CAGNONI PABLO J	President, R&D	Other disposed transaction F	Common Stock	1,280	$69.98	$89,574	219,890
2025-07-02	SWAIN PAULA J	EVP, Human Resources	Other disposed transaction F	Common Stock	6,285	$68.17	$428,448	101,059
2025-06-30	BAKER BROS. ADVISORS LP	—	Equity grant / award A	Common Stock	492	$0.00	$0	28,187,581
2025-06-26	Meury William	Chief Executive Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	110,630	$0.00	$0	110,630
2025-06-10	BRAWLEY OTIS W	Dir	Equity grant / award A · derivative	Non Qualfied Stock Option (right to buy)	9,216	$0.00	$0	9,216
2025-06-10	BRAWLEY OTIS W	Dir	Equity grant / award A	Common Stock	2,518	$0.00	$0	11,252
2025-06-03	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	1,795	$0.00	$0	16,757
2025-06-03	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	1,795	$68.00	$122,060	26,504
2025-06-03	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	1,795	$58.06	$104,218	28,299
2025-06-02	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	651	$64.88	$42,237	22,003
2025-05-30	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	963	$65.71	$63,279	22,654
2025-04-01	Flannelly Barry P	EVP & General Manager US	Equity grant / award A	Common Stock	14,976	$0.00	$0	59,702
2025-04-01	Flannelly Barry P	EVP & General Manager US	Equity grant / award A	Common Stock	11,159	$0.00	$0	44,726
2025-03-31	BAKER BROS. ADVISORS LP	—	Equity grant / award A	Common Stock	487	$0.00	$0	28,184,571
2025-03-25	Trotta Matteo	EVP, GM, Dermatology US	Other disposed transaction F	Common Stock	537	$62.08	$33,337	9,937
2025-03-14	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	19,147	$67.68	$1,295,869	33,567
2025-03-14	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	199	$67.88	$13,508	52,714
2025-03-14	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	461	$67.85	$31,279	52,913
2025-03-04	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	599	$0.00	$0	18,552
2025-03-04	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	599	$69.99	$41,924	25,848
2025-03-04	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	599	$58.06	$34,778	26,447
2025-02-26	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	9,574	$0.00	$0	19,151
2025-02-26	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	4,495	$74.08	$332,990	25,848
2025-02-26	Denton Sheila A.	EVP & General Counsel	Open-market sell S	Common Stock	9,574	$74.07	$709,146	30,343
2025-02-26	Denton Sheila A.	EVP & General Counsel	Exercise / conversion M	Common Stock	9,574	$58.06	$555,866	39,917
2025-01-31	Morrissey Michael James	EVP, Head of Tech. Operations	Equity grant / award A	Common Stock	10,552	$0.00	$0	81,515
2025-01-21	Morrissey Michael James	EVP, Head of Tech. Operations	Other disposed transaction F	Common Stock	429	$73.47	$31,519	70,963
2025-01-17	SWAIN PAULA J	EVP, Human Resources	Equity grant / award A · derivative	Employee Stock Option (right to buy)	14,772	$0.00	$0	14,772
2025-01-15	Flannelly Barry P	EVP & General Manager US	Other disposed transaction F	Common Stock	3,158	$72.46	$228,829	53,374
2025-01-06	Issa Mohamed Khairie	EVP, Head of US Oncology	Equity grant / award A	Common Stock	48,671	$0.00	$0	48,671
2024-12-31	BAKER BROS. ADVISORS LP	—	Equity grant / award A	Common Stock	446	$0.00	$0	28,184,084
2024-12-16	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	650	$69.31	$45,052	23,312
2024-12-13	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	650	$70.64	$45,916	23,962
2024-12-09	SWAIN PAULA J	EVP, Human Resources	Other disposed transaction F	Common Stock	873	$72.11	$62,952	85,203
2024-11-29	Iyengar Vijay K	EVP, GMAPPS	Open-market sell S	Common Stock	5,683	$75.37	$428,328	30,658
2024-11-29	Iyengar Vijay K	EVP, GMAPPS	Open-market sell S	Common Stock	360	$75.60	$27,216	36,341
2024-11-06	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	2,256	$0.00	$0	0
2024-11-06	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	1,424	$0.00	$0	0
2024-11-06	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	2,256	$78.21	$176,442	58,042
2024-11-06	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	1,424	$82.00	$116,768	60,298
2024-11-06	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M	Common Stock	2,256	$68.62	$154,807	61,722
2024-11-06	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M	Common Stock	1,424	$72.27	$102,912	59,466
2024-10-02	Denton Sheila A.	EVP & General Counsel	Other disposed transaction F	Common Stock	2,136	$67.63	$144,458	30,343
2024-10-01	Heeson Lee	EVP, Head of Incyte Intl	Equity grant / award A	Common Stock	26,447	$0.00	$0	26,447
2024-09-30	BAKER BROS. ADVISORS LP	—	Equity grant / award A	Common Stock	496	$0.00	$0	28,183,638
2024-09-13	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	382	$63.37	$24,207	24,443
2024-09-12	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	572	$62.94	$36,002	24,825
2024-08-12	Stein Steven H	EVP & Chief Medical Officer	Open-market sell S	Common Stock	11,608	$60.63	$703,793	90,011
2024-07-25	Iyengar Vijay K	EVP, GMAPPS	Open-market sell S	Common Stock	15,571	$70.00	$1,089,970	36,701
2024-07-15	Stein Steven H	EVP & Chief Medical Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	31,088	$0.00	$0	31,088
2024-07-15	Stein Steven H	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	1,555	$64.25	$99,909	101,619
2024-07-15	Stein Steven H	EVP & Chief Medical Officer	Equity grant / award A	Common Stock	13,895	$0.00	$0	103,174
2024-07-09	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	8,148	$60.00	$488,880	50,534
2024-07-02	Hoppenot Herve	Chairman / CEO	Other disposed transaction F	Common Stock	41,723	$59.02	$2,462,491	460,610
2024-06-28	BAKER BROS. ADVISORS LP	—	Equity grant / award A	Common Stock	537	$0.00	$0	28,183,142
2024-06-12	BAKER BROS. ADVISORS LP	—	Equity grant / award A · derivative	Non- Qualified Stock Options (right to buy)	12,517	$0.00	$0	12,517
2024-06-12	BAKER BROS. ADVISORS LP	—	Other disposed transaction D	Common Stock	5,283,206	$60.00	$316,992,360	28,182,605
2024-06-12	BAKER BROS. ADVISORS LP	—	Other disposed transaction D	Common Stock	175,977	$60.00	$10,558,620	2,811,926
2024-06-12	BAKER BROS. ADVISORS LP	—	Equity grant / award A	Common Stock	2,830	$0.00	$0	33,465,811
2024-06-06	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	1,093	$58.91	$64,389	21,634
2024-05-07	BAKER BROS. ADVISORS LP	—	Exercise / conversion M · derivative	Non- Qualified Stock Options (right to buy)	15,000	$0.00	$0	0
2024-05-07	BAKER BROS. ADVISORS LP	—	Exercise / conversion M	Common Stock	15,000	$49.01	$735,150	33,462,981
2024-03-28	Clancy Paul J	Dir	Equity grant / award A	Common Stock	403	$56.97	$22,959	15,785
2024-03-25	Trotta Matteo	EVP, GM, Dermatology US	Equity grant / award A · derivative	Employee Stock Option (right to buy)	21,868	$0.00	$0	21,868
2024-03-25	Trotta Matteo	EVP, GM, Dermatology US	Equity grant / award A	Common Stock	7,828	$0.00	$0	7,828
2024-02-14	Hoppenot Herve	Chairman / CEO	Equity grant / award A	Common Stock	41,577	$0.00	$0	502,333
2024-02-12	Stamoulis Christiana	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	387	$57.84	$22,384	82,606
2024-01-22	Morrissey Michael James	EVP, Head of Tech. Operations	Other disposed transaction F	Common Stock	108	$61.50	$6,642	72,300
2024-01-18	CAGNONI PABLO J	President, R&D	Equity grant / award A · derivative	Employee Stock Option (right to buy)	21,843	$0.00	$0	21,843
2024-01-17	Dickinson Jonathan Elliott	EVP, General Manager, Europe	Other disposed transaction F	Common Stock	101	$61.48	$6,209	36,496
2024-01-17	Flannelly Barry P	EVP & General Manager US	Other disposed transaction F	Common Stock	3,675	$61.48	$225,939	77,703
2024-01-16	Dickinson Jonathan Elliott	EVP, General Manager, Europe	Other disposed transaction F	Common Stock	101	$61.34	$6,195	36,597
2024-01-03	Stein Steven H	EVP & Chief Medical Officer	Open-market sell S	Common Stock	7,365	$65.51	$482,481	90,218
2024-01-02	Iyengar Vijay K	EVP, GMAPPS	Open-market sell S	Common Stock	657	$65.00	$42,705	43,412
2023-12-29	BAKER BROS. ADVISORS LP	—	Equity grant / award A	Common Stock	556	$0.00	$0	33,447,438
2023-12-13	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	1,067	$62.37	$66,549	23,436
2023-12-12	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	210	$57.36	$12,046	24,503
2023-10-02	Denton Sheila A.	EVP & General Counsel	Equity grant / award A · derivative	Employee Stock Option (right to buy)	28,725	$0.00	$0	28,725
2023-10-02	Denton Sheila A.	EVP & General Counsel	Equity grant / award A	Common Stock	26,524	$0.00	$0	26,524
2023-09-29	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	510	$0.00	$0	33,446,882
2023-09-01	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	8,449	$65.13	$550,283	77,530
2023-08-01	Stein Steven H	EVP & Chief Medical Officer	Open-market sell S	Common Stock	21,511	$63.28	$1,361,216	97,583
2023-07-14	Tray Thomas	Principal Accounting Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	4,204	$0.00	$0	4,204
2023-07-14	Tray Thomas	Principal Accounting Officer	Equity grant / award A	Common Stock	6,015	$0.00	$0	24,539
2023-07-03	Hoppenot Herve	Chairman / CEO	Other disposed transaction F	Common Stock	43,467	$62.08	$2,698,431	391,672
2023-06-30	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	512	$0.00	$0	33,446,372
2023-06-14	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A · derivative	Non- Qualified Stock Option (right to buy)	11,294	$0.00	$0	11,294
2023-06-14	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	2,505	$0.00	$0	33,445,860
2023-06-05	CAGNONI PABLO J	President, R&D	Equity grant / award A	Common Stock	179,613	$0.00	$0	179,613
2023-06-05	CAGNONI PABLO J	President, R&D	Equity grant / award A	Common Stock	192,400	$0.00	$0	192,400
2023-03-31	HARRIGAN EDMUND	Dir	Equity grant / award A	Common Stock	326	$72.27	$23,560	8,995
2023-03-13	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	20,000	$0.00	$0	0
2023-03-13	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M	Common Stock	20,000	$22.74	$454,800	33,442,926
2023-02-16	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	3,693	$0.00	$0	0
2023-02-16	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M	Common Stock	3,693	$65.42	$241,596	56,956
2023-02-13	Stamoulis Christiana	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	331	$80.08	$26,506	76,460
2023-02-13	Stamoulis Christiana	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	848	$80.08	$67,908	76,791
2023-01-31	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	802	$0.00	$0	0
2023-01-31	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	802	$84.06	$67,416	68,524
2023-01-31	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	802	$74.78	$59,974	69,326
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	4,842	$0.00	$0	0
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	5,644	$0.00	$0	0
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	14,374	$0.00	$0	0
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	11,861	$0.00	$0	0
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	10,438	$0.00	$0	0
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	12,865	$0.00	$0	0
2023-01-30	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	4,842	$84.73	$410,263	68,524
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	4,842	$74.78	$362,085	73,366
2023-01-30	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	5,644	$85.07	$480,135	68,524
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	5,644	$83.58	$471,726	74,168
2023-01-30	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	14,374	$84.73	$1,217,909	68,524
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	14,374	$80.50	$1,157,107	82,898
2023-01-30	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	11,861	$84.70	$1,004,627	68,524
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	11,861	$72.27	$857,194	80,385
2023-01-30	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	10,438	$84.70	$884,099	68,524
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	10,438	$68.62	$716,256	78,962
2023-01-30	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	12,865	$84.69	$1,089,537	68,524
2023-01-30	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	12,865	$65.36	$840,856	81,389
2023-01-26	Iyengar Vijay K	EVP, GMAPPS	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,000	$0.00	$0	0
2023-01-26	Iyengar Vijay K	EVP, GMAPPS	Open-market sell S	Common Stock	7,000	$85.00	$595,000	42,835
2023-01-26	Iyengar Vijay K	EVP, GMAPPS	Exercise / conversion M	Common Stock	7,000	$68.62	$480,340	49,835
2023-01-20	Iyengar Vijay K	EVP, GMAPPS	Equity grant / award A · derivative	Employee Stock Option (right to buy)	14,194	$0.00	$0	14,194
2023-01-20	Iyengar Vijay K	EVP, GMAPPS	Equity grant / award A	Common Stock	4,980	$0.00	$0	42,835
2023-01-19	Dickinson Jonathan Elliott	EVP, General Manager, Europe	Other disposed transaction F	Common Stock	105	$83.88	$8,807	30,179
2023-01-17	Dickinson Jonathan Elliott	EVP, General Manager, Europe	Other disposed transaction F	Common Stock	87	$81.26	$7,070	30,284
2023-01-15	Dickinson Jonathan Elliott	EVP, General Manager, Europe	Other disposed transaction F	Common Stock	87	$81.26	$7,070	30,371
2023-01-04	Morrissey Michael James	EVP, Head of Tech. Operations	Other disposed transaction F	Common Stock	117	$79.08	$9,252	55,493
2022-12-30	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	397	$0.00	$0	33,422,926
2022-12-23	Iyengar Vijay K	EVP, GMAPPS	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,000	$0.00	$0	0
2022-12-23	Iyengar Vijay K	EVP, GMAPPS	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,866	$0.00	$0	0
2022-12-23	Iyengar Vijay K	EVP, GMAPPS	Open-market sell S	Common Stock	1,654	$80.79	$133,627	37,855
2022-12-23	Iyengar Vijay K	EVP, GMAPPS	Open-market sell S	Common Stock	804	$80.77	$64,939	39,509
2022-12-23	Iyengar Vijay K	EVP, GMAPPS	Open-market sell S	Common Stock	7,000	$80.80	$565,600	40,313
2022-12-23	Iyengar Vijay K	EVP, GMAPPS	Exercise / conversion M	Common Stock	7,000	$68.62	$480,340	47,313
2022-12-23	Iyengar Vijay K	EVP, GMAPPS	Open-market sell S	Common Stock	7,866	$80.80	$635,573	40,313
2022-12-23	Iyengar Vijay K	EVP, GMAPPS	Exercise / conversion M	Common Stock	7,866	$72.86	$573,117	48,179
2022-12-19	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	1,223	$82.16	$100,482	16,606
2022-12-12	Dhanak Dashyant	EVP & Chief Scientific Officer	Other disposed transaction F	Common Stock	533	$82.36	$43,898	50,702
2022-10-19	HARRIGAN EDMUND	Dir	Equity grant / award A	Common Stock	165	$69.59	$11,482	8,367
2022-10-03	Schaffert Susanne	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	6,751	$0.00	$0	6,751
2022-10-03	Schaffert Susanne	Dir	Equity grant / award A	Common Stock	1,625	$0.00	$0	1,625
2022-09-30	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	457	$0.00	$0	33,422,529
2022-07-22	Tray Thomas	Principal Accounting Officer	Open-market sell S	Common Stock	1,564	$83.13	$130,015	17,702
2022-07-07	Iyengar Vijay K	EVP, GMAPPS	Open-market sell S	Common Stock	5,787	$79.38	$459,372	40,313
2022-07-05	Tray Thomas	Principal Accounting Officer	Other disposed transaction F	Common Stock	987	$79.25	$78,220	19,266
2022-07-02	Tray Thomas	Principal Accounting Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	2,810	$0.00	$0	2,810
2022-07-02	Tray Thomas	Principal Accounting Officer	Equity grant / award A	Common Stock	4,149	$0.00	$0	20,253
2022-06-30	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	433	$0.00	$0	33,422,072
2022-06-28	Stein Steven H	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	11,488	$75.63	$868,837	122,335
2022-06-15	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A · derivative	Non-Qualified Stock Options (right to buy)	9,124	$0.00	$0	9,124
2022-06-15	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	2,144	$0.00	$0	33,421,639
2022-04-09	Pasquale Maria E	EVP & General Counsel	Other disposed transaction F	Common Stock	517	$80.95	$41,851	53,058
2022-04-08	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	21,348	$0.00	$0	0
2022-04-08	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	20,516	$0.00	$0	0
2022-04-08	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	1,248	$82.96	$103,534	65,163
2022-04-08	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	881	$82.96	$73,088	66,411
2022-04-08	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	21,348	$84.00	$1,793,232	67,292
2022-04-08	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M	Common Stock	21,348	$72.27	$1,542,820	88,640
2022-04-08	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	20,516	$83.01	$1,703,033	67,292
2022-04-08	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M	Common Stock	20,516	$68.62	$1,407,808	87,808
2022-03-31	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	440	$0.00	$0	33,419,495
2022-03-10	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	175,795	$73.31	$12,887,303	33,419,055
2022-03-10	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	14,490	$73.31	$1,062,243	2,941,147
2022-03-10	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	1,017	$71.95	$73,177	33,243,260
2022-03-10	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	84	$71.95	$6,044	2,926,657
2022-03-10	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	25,107	$71.90	$1,805,126	33,242,243
2022-03-10	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	2,070	$71.90	$148,827	2,926,573
2022-03-09	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	65,147	$71.72	$4,672,408	33,217,136
2022-03-09	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	5,370	$71.72	$385,142	2,924,503
2022-03-08	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	20,000	$0.00	$0	0
2022-03-08	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	92,385	$70.67	$6,529,310	33,151,989
2022-03-08	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	7,615	$70.67	$538,190	2,919,133
2022-03-08	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M	Common Stock	20,000	$22.05	$441,000	33,059,604
2022-02-22	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	92,234	$68.07	$6,278,507	33,039,604
2022-02-22	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	7,566	$68.07	$515,029	2,891,518
2022-02-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	22,178	$68.43	$1,517,656	32,947,370
2022-02-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	1,827	$68.43	$125,023	2,883,952
2022-02-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	100,731	$68.37	$6,886,696	32,925,192
2022-02-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	8,296	$68.37	$567,174	2,882,125
2022-02-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	285,672	$67.74	$19,352,821	32,824,461
2022-02-17	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	7,300	$67.39	$491,984	32,538,789
2022-02-14	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	182,326	$66.04	$12,040,390	32,531,489
2022-02-14	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	320,526	$66.02	$21,159,973	32,349,163
2022-02-11	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	10,985	$66.95	$735,433	32,028,637
2022-02-11	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	265,522	$66.81	$17,740,295	32,017,652
2022-02-11	Stamoulis Christiana	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	331	$66.76	$22,098	56,285
2022-02-11	Stamoulis Christiana	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	846	$66.76	$56,479	56,616
2022-02-10	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	772,751	$67.54	$52,192,839	31,752,130
2022-02-10	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	6,100	$67.20	$409,899	30,979,379
2022-02-10	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	40,164	$66.57	$2,673,577	30,973,279
2022-01-31	Dickinson Jonathan Elliott	EVP, General Manager, Europe	Open-market sell S	Common Stock	7,375	$74.19	$547,151	30,214
2022-01-24	Morrissey Michael James	EVP, Head of Tech. Operations	Other disposed transaction F	Common Stock	78	$75.34	$5,877	55,610
2022-01-19	Morrissey Michael James	EVP, Head of Tech. Operations	Equity grant / award A	Common Stock	6,959	$0.00	$0	55,688
2022-01-19	Trower Paul	Principal Accounting Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	3,250	$0.00	$0	3,250
2022-01-18	Morrissey Michael James	EVP, Head of Tech. Operations	Other disposed transaction F	Common Stock	101	$75.01	$7,576	48,729
2022-01-07	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non Qualfied Stock Option (right to buy)	10,870	$0.00	$0	0
2022-01-07	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	10,870	$73.31	$796,880	72,371
2022-01-07	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	10,870	$73.21	$795,793	83,241
2022-01-04	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non Qualfied Stock Option (right to buy)	9,319	$0.00	$0	10,870
2022-01-04	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	9,319	$73.46	$684,574	72,371
2022-01-04	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	9,319	$73.21	$682,244	81,690
2022-01-04	Morrissey Michael James	EVP, Head of Tech. Operations	Other disposed transaction F	Common Stock	136	$71.81	$9,766	48,931
2022-01-03	Trower Paul	Principal Accounting Officer	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,396	$0.00	$0	0
2022-01-03	Trower Paul	Principal Accounting Officer	Exercise / conversion M · derivative	Non- Qualified Stock Option (right to buy)	6,818	$0.00	$0	0
2022-01-03	Trower Paul	Principal Accounting Officer	Open-market sell S	Common Stock	1,396	$73.31	$102,341	32,268
2022-01-03	Trower Paul	Principal Accounting Officer	Exercise / conversion M	Common Stock	1,396	$73.21	$102,201	33,664
2022-01-03	Trower Paul	Principal Accounting Officer	Open-market sell S	Common Stock	6,818	$73.31	$499,828	32,268
2022-01-03	Trower Paul	Principal Accounting Officer	Exercise / conversion M	Common Stock	6,818	$73.21	$499,146	39,086
2022-01-01	SWAIN PAULA J	EVP, Human Resources	Equity grant / award A	Common Stock	8,678	$0.00	$0	72,371
2021-12-31	HARRIGAN EDMUND	Dir	Equity grant / award A	Common Stock	253	$73.40	$18,570	5,332
2021-12-23	DIXON WENDY L	Dir	Exercise / conversion M · derivative	Non Qualfied Stock Option (right to buy)	20,000	$0.00	$0	0
2021-12-23	DIXON WENDY L	Dir	Open-market sell S	Common Stock	20,000	$22.05	$441,000	17,259
2021-12-23	DIXON WENDY L	Dir	Exercise / conversion M	Common Stock	20,000	$73.25	$1,465,000	37,259
2021-12-17	BAKER BROS. ADVISORS LP	—	Open-market buy P	Common Stock	193,997	$72.91	$14,144,224	30,932,696
2021-12-17	BAKER BROS. ADVISORS LP	—	Open-market buy P	Common Stock	881,875	$72.77	$64,177,924	30,738,699
2021-12-16	BAKER BROS. ADVISORS LP	—	Open-market buy P	Common Stock	29,703	$72.00	$2,138,616	29,856,824
2021-12-16	BAKER BROS. ADVISORS LP	—	Open-market buy P	Common Stock	139,612	$71.96	$10,045,795	29,827,121
2021-12-15	BAKER BROS. ADVISORS LP	—	Open-market buy P	Common Stock	288,368	$71.91	$20,736,197	29,687,509
2021-12-15	BAKER BROS. ADVISORS LP	—	Open-market buy P	Common Stock	5,382	$71.03	$382,302	29,399,141
2021-12-15	BAKER BROS. ADVISORS LP	—	Open-market buy P	Common Stock	9,893	$70.24	$694,840	29,393,759
2021-12-15	BAKER BROS. ADVISORS LP	—	Open-market buy P	Common Stock	36,476	$69.63	$2,539,700	29,383,866
2021-12-15	BAKER BROS. ADVISORS LP	—	Open-market buy P	Common Stock	9,352	$68.52	$640,841	29,347,390
2021-12-15	BAKER BROS. ADVISORS LP	—	Open-market buy P	Common Stock	861	$67.90	$58,460	29,338,038
2021-12-10	Dhanak Dashyant	EVP & Chief Scientific Officer	Other disposed transaction F	Common Stock	533	$65.40	$34,858	33,464
2021-11-19	SWAIN PAULA J	EVP, Human Resources	Equity grant / award A	Common Stock	2,355	$0.00	$0	63,693
2021-11-19	SWAIN PAULA J	EVP, Human Resources	Equity grant / award A	Common Stock	379	$0.00	$0	61,338
2021-10-01	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	389	$68.67	$26,713	31,263
2021-09-30	HARRIGAN EDMUND	Dir	Equity grant / award A	Common Stock	237	$68.78	$16,301	5,079
2021-09-27	BRAWLEY OTIS W	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	5,910	$0.00	$0	5,910
2021-09-27	BRAWLEY OTIS W	Dir	Equity grant / award A	Common Stock	1,255	$0.00	$0	1,255
2021-09-24	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	382	$0.00	$0	1,912
2021-09-24	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	382	$65.36	$24,968	36,187
2021-09-20	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,356	$0.00	$0	0
2021-09-20	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	1,356	$73.21	$99,273	60,959
2021-09-01	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	388	$76.71	$29,763	31,652
2021-08-02	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	389	$77.49	$30,144	32,040
2021-07-29	Iyengar Vijay K	EVP GPS, BD, & Licensing	Open-market sell S	Common Stock	4,911	$78.29	$384,482	27,005
2021-07-06	Trower Paul	Principal Accounting Officer	Other disposed transaction F	Common Stock	104	$83.34	$8,667	32,268
2021-07-02	Trower Paul	Principal Accounting Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	3,250	$0.00	$0	3,250
2021-07-02	Trower Paul	Principal Accounting Officer	Other disposed transaction F	Common Stock	872	$83.58	$72,882	32,372
2021-07-02	Trower Paul	Principal Accounting Officer	Equity grant / award A	Common Stock	4,521	$0.00	$0	33,244
2021-07-01	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	396	$84.09	$33,300	26,149
2021-06-30	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	345	$0.00	$0	29,336,784
2021-06-28	Stein Steven H	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	22,079	$85.61	$1,890,183	97,665
2021-06-18	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	255	$0.00	$0	2,294
2021-06-18	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	255	$65.36	$16,667	30,193
2021-06-10	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,845	$0.00	$0	26,914
2021-06-10	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	3,845	$87.00	$334,515	26,545
2021-06-10	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M	Common Stock	3,845	$65.42	$251,540	30,390
2021-06-01	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	395	$84.13	$33,231	26,545
2021-05-26	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A · derivative	Non-Qualified Stock Options (right to buy)	8,010	$0.00	$0	8,010
2021-05-26	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	1,923	$0.00	$0	29,336,439
2021-05-14	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	20,000	$0.00	$0	0
2021-05-14	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M	Common Stock	20,000	$18.97	$379,400	29,334,516
2021-05-03	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	396	$85.40	$33,818	26,940
2021-04-23	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	127	$0.00	$0	2,549
2021-04-23	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	127	$65.36	$8,301	29,938
2021-04-09	Pasquale Maria E	EVP & General Counsel	Other disposed transaction F	Common Stock	517	$79.96	$41,339	29,811
2021-04-01	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	396	$81.57	$32,302	27,336
2021-03-31	FOUSE JACQUALYN A	Dir	Equity grant / award A	Common Stock	251	$81.27	$20,399	5,510
2021-03-29	Morrissey Michael James	EVP, Head of Tech. Operations	Open-market sell S	Common Stock	20,000	$81.08	$1,621,600	45,452
2021-03-12	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	128	$0.00	$0	2,676
2021-03-12	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	128	$65.36	$8,366	30,328
2021-03-01	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	395	$79.73	$31,493	27,732
2021-02-23	Hoppenot Herve	Chairman / CEO	Open-market buy P	Common Stock	12,925	$77.37	$1,000,007	284,231
2021-02-16	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	127	$0.00	$0	2,804
2021-02-16	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	127	$65.36	$8,301	30,200
2021-02-11	Stamoulis Christiana	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	1,210	$84.99	$102,838	32,611
2021-02-01	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	961	$0.00	$0	30,759
2021-02-01	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	395	$90.00	$35,550	28,127
2021-02-01	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	961	$90.00	$86,490	28,522
2021-02-01	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M	Common Stock	961	$65.42	$62,869	29,483
2021-01-25	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	19,986	$0.00	$0	0
2021-01-25	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,559	$0.00	$0	0
2021-01-25	Wenqing Yao	EVP, Head of Discovery Chem	Open-market sell S	Common Stock	19,986	$100.00	$1,998,600	143,784
2021-01-25	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M	Common Stock	19,986	$73.21	$1,463,175	163,770
2021-01-25	Wenqing Yao	EVP, Head of Discovery Chem	Open-market sell S	Common Stock	1,559	$100.00	$155,900	143,784
2021-01-25	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M	Common Stock	1,559	$73.21	$114,134	145,343
2021-01-15	Stamoulis Christiana	EVP & Chief Financial Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	12,743	$0.00	$0	12,743
2021-01-15	Stamoulis Christiana	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	11,522	$0.00	$0	33,821
2021-01-11	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	127	$0.00	$0	2,931
2021-01-11	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	127	$65.36	$8,301	30,073
2021-01-04	Morrissey Michael James	EVP, Head of Tech. Operations	Other disposed transaction F	Common Stock	136	$86.45	$11,757	48,421
2020-12-31	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	343	$0.00	$0	29,314,152
2020-12-11	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	128	$0.00	$0	3,058
2020-12-11	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	128	$65.36	$8,366	29,946
2020-12-10	Dhanak Dashyant	EVP & Chief Scientific Officer	Other disposed transaction F	Common Stock	720	$82.05	$59,076	28,522
2020-11-16	Wenqing Yao	EVP, Head of Discovery Chem	Equity grant / award A	Common Stock	1,232	$0.00	$0	156,851
2020-11-12	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	127	$0.00	$0	3,186
2020-11-12	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	127	$65.36	$8,301	28,586
2020-11-10	BIENAIME JEAN JACQUES	Dir	Open-market sell S	Common Stock	798	$83.00	$66,234	8,646
2020-11-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	961	$0.00	$0	31,720
2020-11-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	961	$85.17	$81,848	28,010
2020-11-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M	Common Stock	961	$65.42	$62,869	28,971
2020-11-02	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	20,000	$0.00	$0	0
2020-11-02	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	20,000	$86.60	$1,732,000	39,984
2020-11-02	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M	Common Stock	20,000	$48.44	$968,800	59,984
2020-10-12	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	128	$0.00	$0	3,313
2020-10-12	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	128	$65.36	$8,366	28,459
2020-10-09	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non Qualified Stock Option (right to buy)	1,423	$0.00	$0	10,438
2020-10-09	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	1,423	$95.00	$135,185	28,331
2020-10-09	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	1,423	$68.62	$97,646	29,754
2020-10-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	961	$0.00	$0	32,681
2020-10-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	961	$91.97	$88,383	28,010
2020-10-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M	Common Stock	961	$65.42	$62,869	28,971
2020-09-30	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	317	$0.00	$0	29,313,809
2020-09-11	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	127	$0.00	$0	3,441
2020-09-11	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	127	$65.36	$8,301	28,331
2020-09-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non Qualified Stock Option (right to buy)	2,193	$0.00	$0	12,865
2020-09-10	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	2,193	$90.83	$199,190	28,204
2020-09-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	2,193	$65.36	$143,334	30,397
2020-09-08	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	961	$0.00	$0	33,642
2020-09-08	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	961	$88.94	$85,471	28,010
2020-09-08	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M	Common Stock	961	$65.42	$62,869	28,971
2020-08-27	DIXON WENDY L	Dir	Exercise / conversion M · derivative	Non Qualfied Stock Option (right to buy)	20,000	$0.00	$0	0
2020-08-27	DIXON WENDY L	Dir	Open-market sell S	Common Stock	20,000	$94.51	$1,890,200	14,243
2020-08-27	DIXON WENDY L	Dir	Exercise / conversion M	Common Stock	20,000	$18.97	$379,400	34,243
2020-08-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	128	$0.00	$0	3,568
2020-08-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	128	$65.36	$8,366	28,204
2020-08-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	961	$0.00	$0	34,603
2020-08-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	961	$97.80	$93,986	28,010
2020-08-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M	Common Stock	961	$65.42	$62,869	28,971
2020-07-15	Wenqing Yao	EVP, Head of Discovery Chem	Other disposed transaction F	Common Stock	639	$104.25	$66,616	155,619
2020-07-13	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	2,419	$0.00	$0	0
2020-07-13	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M	Common Stock	2,419	$65.42	$158,251	28,010
2020-07-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	127	$0.00	$0	3,696
2020-07-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	127	$65.36	$8,301	28,076
2020-07-08	Iyengar Vijay K	EVP GPS, BD, & Licensing	Open-market sell S	Common Stock	475	$108.56	$51,566	25,926
2020-07-07	Iyengar Vijay K	EVP GPS, BD, & Licensing	Open-market sell S	Common Stock	3,120	$107.98	$336,898	26,401
2020-07-06	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	15,648	$0.00	$0	0
2020-07-06	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	905	$0.00	$0	0
2020-07-06	Wenqing Yao	EVP, Head of Discovery Chem	Open-market sell S	Common Stock	15,648	$107.32	$1,679,343	156,258
2020-07-06	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M	Common Stock	15,648	$64.55	$1,010,078	171,906
2020-07-06	Wenqing Yao	EVP, Head of Discovery Chem	Open-market sell S	Common Stock	905	$107.32	$97,125	156,258
2020-07-06	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M	Common Stock	905	$64.55	$58,418	157,163
2020-07-06	Wenqing Yao	EVP, Head of Discovery Chem	Other disposed transaction F	Common Stock	404	$107.79	$43,547	156,258
2020-07-02	Wenqing Yao	EVP, Head of Discovery Chem	Equity grant / award A · derivative	Employee Stock Option (right to buy)	12,743	$0.00	$0	12,743
2020-07-02	Wenqing Yao	EVP, Head of Discovery Chem	Other disposed transaction F	Common Stock	2,187	$106.47	$232,850	156,662
2020-07-02	Wenqing Yao	EVP, Head of Discovery Chem	Equity grant / award A	Common Stock	6,661	$0.00	$0	158,849
2020-06-30	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	294	$0.00	$0	29,313,492
2020-06-26	Hoppenot Herve	Chairman / CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	119,501	$0.00	$0	0
2020-06-26	Hoppenot Herve	Chairman / CEO	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	4,647	$0.00	$0	0
2020-06-26	Hoppenot Herve	Chairman / CEO	Open-market sell S	Common Stock	119,501	$102.91	$12,297,848	240,603
2020-06-26	Hoppenot Herve	Chairman / CEO	Exercise / conversion M	Common Stock	119,501	$64.55	$7,713,790	360,104
2020-06-26	Hoppenot Herve	Chairman / CEO	Open-market sell S	Common Stock	4,647	$102.91	$478,223	240,603
2020-06-26	Hoppenot Herve	Chairman / CEO	Exercise / conversion M	Common Stock	4,647	$64.55	$299,964	245,250
2020-06-23	Trower Paul	Principal Accounting Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	6,943	$0.00	$0	0
2020-06-23	Trower Paul	Principal Accounting Officer	Open-market sell S	Common Stock	6,943	$110.00	$763,730	21,734
2020-06-23	Trower Paul	Principal Accounting Officer	Exercise / conversion M	Common Stock	6,943	$64.55	$448,171	28,677
2020-06-22	Dickinson Jonathan Elliott	EVP, General Manager, Europe	Open-market sell S	Common Stock	9,000	$105.31	$947,790	21,762
2020-06-19	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non Qualified Stock Option (right to buy)	1,423	$0.00	$0	11,861
2020-06-19	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	1,423	$100.00	$142,300	23,661
2020-06-19	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	1,423	$72.27	$102,840	25,084
2020-06-18	Wenqing Yao	EVP, Head of Discovery Chem	Equity grant / award A	Common Stock	25,000	$0.00	$0	152,188
2020-06-17	INCYTE CORP	10%	Open-market sell S	Common Stock	141,920	$3.66	$518,831	16,972,968
2020-06-16	INCYTE CORP	10%	Open-market sell S	Common Stock	72,080	$3.66	$264,007	17,114,888
2020-06-15	INCYTE CORP	10%	Open-market sell S	Common Stock	384,025	$3.57	$1,372,160	17,186,968
2020-06-12	INCYTE CORP	10%	Open-market sell S	Common Stock	9,100	$3.58	$32,556	17,570,993
2020-06-12	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	127	$0.00	$0	3,823
2020-06-12	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	127	$65.36	$8,301	23,661
2020-06-11	INCYTE CORP	10%	Open-market sell S	Common Stock	183,875	$3.77	$692,786	17,580,093
2020-06-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non Qualified Stock Option (right to buy)	2,192	$0.00	$0	15,058
2020-06-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non Qualified Stock Option (right to buy)	1,423	$0.00	$0	11,861
2020-06-10	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	2,192	$94.19	$206,464	23,534
2020-06-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	2,192	$65.36	$143,269	25,726
2020-06-10	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	1,423	$95.00	$135,185	23,534
2020-06-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	1,423	$68.62	$97,646	24,957
2020-06-08	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	961	$0.00	$0	36,525
2020-06-08	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	961	$91.87	$88,287	19,987
2020-06-08	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M	Common Stock	961	$65.42	$62,869	20,948
2020-05-28	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Common Stock	1	$102.55	$103	29,313,198
2020-05-26	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A · derivative	Non-Qualified Stock Options (right to buy)	10,514	$0.00	$0	10,514
2020-05-26	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	1,282	$0.00	$0	29,313,197
2020-05-11	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	128	$0.00	$0	3,950
2020-05-11	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	128	$65.36	$8,366	23,534
2020-05-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	961	$0.00	$0	37,486
2020-05-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Open-market sell S	Common Stock	961	$96.84	$93,063	19,987
2020-05-06	Dhanak Dashyant	EVP & Chief Scientific Officer	Exercise / conversion M	Common Stock	961	$65.42	$62,869	20,948
2020-04-28	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	20,000	—	$266,800	0
2020-04-28	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M	Common Stock	20,000	$13.34	$266,800	29,311,915
2020-04-17	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non Qualified Stock Option (right to buy)	9,488	$0.00	$0	13,284
2020-04-17	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	9,488	$100.00	$948,800	22,899
2020-04-17	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	9,488	$72.27	$685,698	32,837
2020-04-17	Trower Paul	Principal Accounting Officer	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,143	$0.00	$0	0
2020-04-17	Trower Paul	Principal Accounting Officer	Open-market sell S	Common Stock	1,143	$100.00	$114,300	21,324
2020-04-17	Trower Paul	Principal Accounting Officer	Exercise / conversion M	Common Stock	1,143	$64.55	$73,781	22,467
2020-04-16	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non Qualified Stock Option (right to buy)	9,488	$0.00	$0	13,284
2020-04-16	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	9,488	$95.00	$901,360	22,899
2020-04-16	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	9,488	$68.62	$651,067	32,837
2020-04-14	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Non Qualified Stock Option (right to buy)	17,827	$0.00	$0	17,250
2020-04-14	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	17,827	$90.00	$1,604,430	22,899
2020-04-14	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	17,827	$65.36	$1,165,173	40,726
2020-04-13	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	127	$0.00	$0	4,078
2020-04-13	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	965	$85.68	$82,681	22,899
2020-04-13	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	127	$65.36	$8,301	23,864
2020-04-09	Pasquale Maria E	EVP & General Counsel	Other disposed transaction F	Common Stock	517	$86.81	$44,881	23,737
2020-04-06	Pasquale Maria E	EVP & General Counsel	Open-market sell S	Common Stock	1,842	$85.00	$156,570	24,254
2020-03-31	HARRIGAN EDMUND	Dir	Equity grant / award A	Common Stock	202	$73.23	$14,792	664
2020-03-26	High Katherine A	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option	1,285	$0.00	$0	1,285
2020-03-26	High Katherine A	Dir	Equity grant / award A	Common Stock	139	$0.00	$0	139
2020-03-11	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	128	$0.00	$0	4,205
2020-03-11	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	128	$65.36	$8,366	26,096
2020-02-21	BROOKE PAUL A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	20,000	$0.00	$0	0
2020-02-21	BROOKE PAUL A	Dir	Exercise / conversion M	Common Stock	20,000	$13.34	$266,800	221,584
2020-02-19	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	1,639
2020-02-19	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	2,500	$80.00	$200,000	48,493
2020-02-19	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	2,500	$64.55	$161,375	50,993
2020-02-13	Iyengar Vijay K	EVP GPS, BD, & Licensing	Equity grant / award A	Common Stock	6,881	$0.00	$0	24,490
2020-02-11	Stamoulis Christiana	EVP & Chief Financial Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	34,240	$0.00	$0	34,240
2020-02-11	Stamoulis Christiana	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	780	$76.14	$59,389	14,089
2020-02-11	Stamoulis Christiana	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	4,268	$76.14	$324,966	14,869
2020-02-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	127	$0.00	$0	4,333
2020-02-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	127	$65.36	$8,301	19,087
2020-02-05	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	17,542	$0.00	$0	0
2020-02-05	Wenqing Yao	EVP, Head of Discovery Chem	Open-market sell S	Common Stock	17,542	$75.97	$1,332,666	95,308
2020-02-05	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M	Common Stock	17,542	$18.32	$321,369	112,850
2020-01-23	Morrissey Michael James	EVP, Head of Tech. Operations	Other disposed transaction F	Common Stock	64	$78.24	$5,007	48,557
2020-01-17	Trower Paul	Principal Accounting Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	2,290	$0.00	$0	2,290
2020-01-17	Trower Paul	Principal Accounting Officer	Equity grant / award A	Common Stock	4,018	$0.00	$0	21,324
2020-01-15	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	4,139
2020-01-15	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	2,500	$81.12	$202,800	41,612
2020-01-15	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	2,500	$64.55	$161,375	44,112
2020-01-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	127	$0.00	$0	4,460
2020-01-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	127	$65.36	$8,301	18,960
2020-01-06	Dickinson Jonathan Elliott	EVP, General Manager, Europe	Other disposed transaction F	Common Stock	111	$77.34	$8,585	24,733
2020-01-02	Hoppenot Herve	Chairman / CEO	Other disposed transaction F	Common Stock	28,345	$85.97	$2,436,820	183,851
2019-12-31	FOUSE JACQUALYN A	Dir	Equity grant / award A	Common Stock	218	$87.32	$19,036	3,049
2019-12-17	HARRIGAN EDMUND	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option	4,360	$0.00	$0	4,360
2019-12-17	HARRIGAN EDMUND	Dir	Equity grant / award A	Common Stock	462	$0.00	$0	462
2019-12-16	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	6,639
2019-12-16	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	2,500	$91.61	$229,025	41,612
2019-12-16	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	2,500	$64.55	$161,375	44,112
2019-12-12	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	77	$0.00	$0	4,587
2019-12-12	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	77	$65.36	$5,033	18,833
2019-12-10	Dhanak Dashyant	EVP & Chief Scientific Officer	Other disposed transaction F	Common Stock	533	$95.72	$51,019	13,106
2019-12-02	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	16,835	$0.00	$0	17,542
2019-12-02	Wenqing Yao	EVP, Head of Discovery Chem	Open-market sell S	Common Stock	16,835	$95.00	$1,599,325	95,308
2019-12-02	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M	Common Stock	16,835	$18.32	$308,417	112,143
2019-11-29	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,165	$0.00	$0	34,377
2019-11-29	Wenqing Yao	EVP, Head of Discovery Chem	Open-market sell S	Common Stock	3,165	$95.00	$300,675	95,308
2019-11-29	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M	Common Stock	3,165	$18.32	$57,983	98,473
2019-11-25	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,720	$0.00	$0	0
2019-11-25	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	422	$0.00	$0	20,000
2019-11-25	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	1,720	$90.00	$154,800	16,979
2019-11-25	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M	Common Stock	1,720	$48.44	$83,317	18,699
2019-11-25	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	422	$90.00	$37,980	16,979
2019-11-25	Flannelly Barry P	EVP & General Manager US	Exercise / conversion M	Common Stock	422	$48.44	$20,442	17,401
2019-11-15	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	9,139
2019-11-15	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	2,500	$86.46	$216,150	41,612
2019-11-15	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	2,500	$64.55	$161,375	44,112
2019-11-13	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	76	$0.00	$0	4,664
2019-11-13	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	76	$65.36	$4,967	18,756
2019-11-08	DIXON WENDY L	Dir	Exercise / conversion M · derivative	Non Qualfied Stock Option (right to buy)	18,334	$0.00	$0	0
2019-11-08	DIXON WENDY L	Dir	Exercise / conversion M · derivative	Non Qualfied Stock Option (right to buy)	22,884	$0.00	$0	0
2019-11-08	DIXON WENDY L	Dir	Open-market sell S	Common Stock	18,334	$83.87	$1,537,673	12,340
2019-11-08	DIXON WENDY L	Dir	Exercise / conversion M	Common Stock	18,334	$12.46	$228,442	30,674
2019-11-08	DIXON WENDY L	Dir	Open-market sell S	Common Stock	22,884	$83.87	$1,919,281	12,340
2019-11-08	DIXON WENDY L	Dir	Exercise / conversion M	Common Stock	22,884	$12.46	$285,135	35,224
2019-11-07	DIXON WENDY L	Dir	Exercise / conversion M · derivative	Non Qualfied Stock Option (right to buy)	1,540	$0.00	$0	22,884
2019-11-07	DIXON WENDY L	Dir	Open-market sell S	Common Stock	1,540	$83.60	$128,744	12,340
2019-11-07	DIXON WENDY L	Dir	Exercise / conversion M	Common Stock	1,540	$12.46	$19,188	13,880
2019-11-06	DIXON WENDY L	Dir	Exercise / conversion M · derivative	Non Qualfied Stock Option (right to buy)	10,576	$0.00	$0	24,424
2019-11-06	DIXON WENDY L	Dir	Open-market sell S	Common Stock	10,576	$84.16	$890,076	12,340
2019-11-06	DIXON WENDY L	Dir	Exercise / conversion M	Common Stock	10,576	$12.46	$131,777	22,916
2019-11-01	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,960	$0.00	$0	52,542
2019-11-01	Wenqing Yao	EVP, Head of Discovery Chem	Open-market sell S	Common Stock	7,960	$85.00	$676,600	95,308
2019-11-01	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M	Common Stock	7,960	$18.32	$145,827	103,268
2019-10-30	Wenqing Yao	EVP, Head of Discovery Chem	Equity grant / award A	Common Stock	50,000	$0.00	$0	95,308
2019-10-30	Stein Steven H	EVP & Chief Medical Officer	Equity grant / award A	Common Stock	50,000	$0.00	$0	66,473
2019-10-29	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,040	$0.00	$0	60,502
2019-10-29	Wenqing Yao	EVP, Head of Discovery Chem	Open-market sell S	Common Stock	2,040	$85.00	$173,400	45,308
2019-10-29	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M	Common Stock	2,040	$18.32	$37,373	47,348
2019-10-22	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	11,639
2019-10-22	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	2,500	$80.00	$200,000	41,612
2019-10-22	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	2,500	$64.55	$161,375	44,112
2019-10-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	77	$0.00	$0	4,740
2019-10-10	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	77	$65.36	$5,033	18,680
2019-09-30	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	364	$74.23	$27,020	29,291,207
2019-09-18	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	14,139
2019-09-18	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	2,500	$80.00	$200,000	41,612
2019-09-18	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	2,500	$64.55	$161,375	44,112
2019-09-17	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	2,491	$77.71	$193,576	16,757
2019-09-09	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	76	$0.00	$0	4,817
2019-09-09	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	76	$65.36	$4,967	18,603
2019-08-15	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	16,639
2019-08-15	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	2,500	$80.96	$202,400	41,612
2019-08-15	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	2,500	$64.55	$161,375	44,112
2019-08-09	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,223	$0.00	$0	4,893
2019-08-09	Pasquale Maria E	EVP & General Counsel	Exercise / conversion M	Common Stock	1,223	$65.36	$79,935	18,527
2019-08-06	FRIEDMAN PAUL A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	77,934	$0.00	$0	0
2019-08-06	FRIEDMAN PAUL A	Dir	Open-market sell S	Common Stock	77,934	$82.20	$6,406,175	255,531
2019-08-06	FRIEDMAN PAUL A	Dir	Exercise / conversion M	Common Stock	77,934	$18.32	$1,427,751	333,465
2019-08-02	BIENAIME JEAN JACQUES	Dir	Open-market sell S	Common Stock	377	$84.73	$31,943	7,055
2019-08-02	FRIEDMAN PAUL A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	22,066	$0.00	$0	77,934
2019-08-02	FRIEDMAN PAUL A	Dir	Open-market sell S	Common Stock	22,066	$84.41	$1,862,591	255,531
2019-08-02	FRIEDMAN PAUL A	Dir	Exercise / conversion M	Common Stock	22,066	$18.32	$404,249	277,597
2019-08-01	BIENAIME JEAN JACQUES	Dir	Open-market sell S	Common Stock	1,347	$85.16	$114,711	7,432
2019-07-17	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	959	$79.91	$76,634	19,248
2019-07-15	Hoppenot Herve	Chairman / CEO	Other disposed transaction F	Common Stock	2,400	$81.39	$195,336	212,196
2019-07-05	Wenqing Yao	EVP, Head of Discovery Chem	Other disposed transaction F	Common Stock	404	$85.28	$34,453	45,947
2019-07-02	Hoppenot Herve	Chairman / CEO	Equity grant / award A · derivative	Employee Stock Option (right to buy)	96,327	$0.00	$0	96,327
2019-07-02	Hoppenot Herve	Chairman / CEO	Other disposed transaction F	Common Stock	2,410	$85.01	$204,874	216,148
2019-07-02	Hoppenot Herve	Chairman / CEO	Equity grant / award A	Common Stock	39,648	$0.00	$0	218,558
2019-06-28	FOUSE JACQUALYN A	Dir	Equity grant / award A	Common Stock	203	$84.96	$17,247	2,580
2019-06-24	Stein Steven H	EVP & Chief Medical Officer	Open-market sell S	Common Stock	8,357	$87.96	$735,082	10,805
2019-06-17	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	21,639
2019-06-17	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	2,500	$80.00	$200,000	36,513
2019-06-17	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	2,500	$64.55	$161,375	39,013
2019-06-06	BAKER BROS. ADVISORS LP	Dir	Other acquired transaction J	Common Stock	220,141	$0.00	$0	281,190
2019-06-06	BAKER BROS. ADVISORS LP	Dir	Other disposed transaction J	Common Stock	692,706	$0.00	$0	0
2019-06-06	BAKER BROS. ADVISORS LP	Dir	Other disposed transaction J	Common Stock	1,603,238	$0.00	$0	2,826,766
2019-05-09	Iyengar Vijay K	EVP GPS, BD, & Licensing	Other disposed transaction F	Common Stock	1,434	$82.02	$117,617	12,468
2019-04-26	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A · derivative	Non-Qualified Stock Options (right to buy)	12,472	$0.00	$0	12,472
2019-04-26	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	1,520	$0.00	$0	812,602
2019-04-09	Pasquale Maria E	EVP & General Counsel	Other disposed transaction F	Common Stock	517	$82.73	$42,771	11,013
2019-04-01	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	8,218	$0.00	$0	0
2019-04-01	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,782	$0.00	$0	0
2019-04-01	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Commons Stock	8,218	$87.01	$715,048	36,513
2019-04-01	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Commons Stock	8,218	$18.32	$150,554	44,731
2019-04-01	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	1,782	$87.01	$155,052	36,513
2019-04-01	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	1,782	$18.32	$32,646	38,295
2019-03-29	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	220	$86.01	$18,922	811,082
2019-03-01	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	10,000	$0.00	$0	1,782
2019-03-01	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	10,000	$86.68	$866,800	36,513
2019-03-01	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	10,000	$18.32	$183,200	46,513
2019-02-26	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	20,000	$0.00	$0	0
2019-02-26	BAKER BROS. ADVISORS LP	Dir	Exercise / conversion M	Common Stock	20,000	$2.80	$56,000	29,288,793
2019-02-14	Hoppenot Herve	Chairman / CEO	Equity grant / award A	Common Stock	20,971	$0.00	$0	158,503
2019-02-11	Stamoulis Christiana	EVP & Chief Financial Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	72,809	$0.00	$0	72,809
2019-02-11	Stamoulis Christiana	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	10,285	$80.21	$824,960	10,285
2019-02-01	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	10,000	$0.00	$0	11,782
2019-02-01	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	10,000	$81.19	$811,900	31,124
2019-02-01	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	10,000	$18.32	$183,200	41,124
2019-01-28	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	1,000	$80.00	$80,000	8,944
2019-01-17	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	15,354	$0.00	$0	0
2019-01-17	Wenqing Yao	EVP, Head of Discovery Chem	Open-market sell S	Common Stock	15,354	$77.61	$1,191,624	34,409
2019-01-17	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M	Common Stock	15,354	$17.79	$273,148	49,763
2019-01-15	Trower Paul	Principal Accounting Officer	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	5,813	$0.00	$0	0
2019-01-15	Trower Paul	Principal Accounting Officer	Open-market sell S	Common Stock	5,813	$75.00	$435,975	13,900
2019-01-15	Trower Paul	Principal Accounting Officer	Exercise / conversion M	Common Stock	5,813	$17.79	$103,413	19,713
2019-01-08	Flannelly Barry P	EVP & General Manager US	Open-market sell S	Common Stock	1,714	$75.56	$129,510	9,944
2019-01-07	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	10,000	$0.00	$0	15,354
2019-01-07	Wenqing Yao	EVP, Head of Discovery Chem	Other disposed transaction F	Common Stock	808	$74.21	$59,962	34,409
2019-01-07	Wenqing Yao	EVP, Head of Discovery Chem	Open-market sell S	Common Stock	10,000	$75.00	$750,000	35,217
2019-01-07	Wenqing Yao	EVP, Head of Discovery Chem	Exercise / conversion M	Common Stock	10,000	$17.79	$177,900	45,217
2019-01-04	Wenqing Yao	EVP, Head of Discovery Chem	Equity grant / award A · derivative	Employee Stock Option (right to buy)	22,772	$0.00	$0	22,772
2019-01-02	Hoppenot Herve	Chairman / CEO	Other disposed transaction F	Common Stock	27,630	$63.56	$1,756,163	157,136
2018-12-31	FOUSE JACQUALYN A	Dir	Equity grant / award A	Common Stock	196	$63.59	$12,464	712
2018-12-10	Dhanak Dashyant	EVP & Chief Scientific Officer	Equity grant / award A · derivative	Employee Stock Option (right to buy)	48,403	$0.00	$0	48,403
2018-12-10	Dhanak Dashyant	EVP & Chief Scientific Officer	Equity grant / award A	Common Stock	6,878	$0.00	$0	6,878
2018-11-08	BIENAIME JEAN JACQUES	Dir	Open-market buy P	Common Stock	500	$68.91	$34,455	6,668
2018-10-03	Trower Paul	Principal Accounting Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	10,000	$0.00	$0	9,187
2018-10-03	Trower Paul	Principal Accounting Officer	Open-market sell S	Common Stock	10,000	$70.00	$700,000	14,172
2018-10-03	Trower Paul	Principal Accounting Officer	Exercise / conversion M	Common Stock	10,000	$17.79	$177,900	24,172
2018-09-28	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Common Stock	275	$69.08	$18,997	810,564
2018-09-04	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	10,000	$0.00	$0	61,782
2018-09-04	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	10,000	$73.21	$732,100	32,324
2018-09-04	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	10,000	$18.32	$183,200	42,324
2018-08-21	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	10,000	$0.00	$0	71,782
2018-08-21	SWAIN PAULA J	EVP, Human Resources	Open-market sell S	Common Stock	10,000	$70.00	$700,000	32,324
2018-08-21	SWAIN PAULA J	EVP, Human Resources	Exercise / conversion M	Common Stock	10,000	$18.32	$183,200	42,324

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

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