Financial Metrics

ISRG INTUITIVE SURGICAL INC

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	3.54	—	USD/shares	10-Q	2017-04-19
Quarterly	2016-06-30	4.71	+33.1%	USD/shares	10-Q	2017-07-21
Quarterly	2016-09-30	1.77	-62.4%	USD/shares	10-Q	2017-10-20
Quarterly	2017-03-31	1.57	-11.3%	USD/shares	10-Q	2018-04-18
Quarterly	2017-06-30	1.94	+23.6%	USD/shares	10-Q	2018-07-20
Quarterly	2017-09-30	2.56	+32.0%	USD/shares	10-Q	2018-10-22
Quarterly	2018-03-31	2.44	-4.7%	USD/shares	10-Q	2019-04-19
Quarterly	2018-06-30	2.15	-11.9%	USD/shares	10-Q	2019-07-22
Quarterly	2018-09-30	2.45	+14.0%	USD/shares	10-Q	2019-10-18
Quarterly	2019-03-31	2.56	+4.5%	USD/shares	10-Q	2020-04-17
Quarterly	2019-06-30	2.67	+4.3%	USD/shares	10-Q	2020-07-23
Quarterly	2019-09-30	3.33	+24.7%	USD/shares	10-Q	2020-10-19
Quarterly	2020-03-31	2.62	-21.3%	USD/shares	10-Q	2021-04-21
Quarterly	2020-06-30	0.57	-78.2%	USD/shares	10-Q	2021-07-21
Quarterly	2020-09-30	0.87	+52.6%	USD/shares	10-Q	2021-10-20
Quarterly	2021-03-31	1.17	+34.5%	USD/shares	10-Q	2022-04-22
Quarterly	2021-06-30	1.42	+21.4%	USD/shares	10-Q	2022-07-22
Quarterly	2021-09-30	1.04	-26.8%	USD/shares	10-Q	2022-10-21
Quarterly	2022-03-31	1.0	-3.8%	USD/shares	10-Q	2023-04-20
Quarterly	2022-06-30	0.85	-15.0%	USD/shares	10-Q	2023-07-24
Quarterly	2022-09-30	0.9	+5.9%	USD/shares	10-Q	2023-10-20
Quarterly	2023-03-31	1.0	+11.1%	USD/shares	10-Q	2024-04-19
Quarterly	2023-06-30	1.18	+18.0%	USD/shares	10-Q	2024-07-19
Quarterly	2023-09-30	1.16	-1.7%	USD/shares	10-Q	2024-10-18
Quarterly	2024-03-31	1.51	+30.2%	USD/shares	10-Q	2025-04-23
Quarterly	2024-06-30	1.46	-3.3%	USD/shares	10-Q	2025-07-23
Quarterly	2024-09-30	1.56	+6.8%	USD/shares	10-Q	2025-10-22
Quarterly	2025-03-31	1.92	+23.1%	USD/shares	10-Q	2025-04-23
Quarterly	2025-06-30	1.81	-5.7%	USD/shares	10-Q	2025-07-23
Quarterly	2025-09-30	1.95	+7.7%	USD/shares	10-Q	2025-10-22
Annual	2016-12-31	6.26	—	USD/shares	10-K	2019-02-04
Annual	2017-12-31	5.77	-7.8%	USD/shares	10-K	2020-02-07
Annual	2018-12-31	9.49	+64.5%	USD/shares	10-K	2021-02-10
Annual	2019-12-31	3.85	-59.4%	USD/shares	10-K	2022-02-03
Annual	2020-12-31	2.94	-23.6%	USD/shares	10-K	2023-02-10
Annual	2021-12-31	4.66	+58.5%	USD/shares	10-K	2024-01-31
Annual	2022-12-31	3.65	-21.7%	USD/shares	10-K	2025-01-31
Annual	2023-12-31	5.03	+37.8%	USD/shares	10-K	2026-02-03
Annual	2024-12-31	6.42	+27.6%	USD/shares	10-K	2026-02-03
Annual	2025-12-31	7.87	+22.6%	USD/shares	10-K	2026-02-03

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	38500000.0	—	shares	10-Q	2017-04-19
Quarterly	2016-06-30	39200000.0	+1.8%	shares	10-Q	2017-07-21
Quarterly	2016-09-30	119100000.0	+203.8%	shares	10-Q	2017-10-20
Quarterly	2017-03-31	115500000.0	-3.0%	shares	10-Q	2018-04-18
Quarterly	2017-06-30	115200000.0	-0.3%	shares	10-Q	2018-07-20
Quarterly	2017-09-30	116800000.0	+1.4%	shares	10-Q	2018-10-22
Quarterly	2018-03-31	118000000.0	+1.0%	shares	10-Q	2019-04-19
Quarterly	2018-06-30	118500000.0	+0.4%	shares	10-Q	2019-07-22
Quarterly	2018-09-30	119200000.0	+0.6%	shares	10-Q	2019-10-18
Quarterly	2019-03-31	119600000.0	+0.3%	shares	10-Q	2020-04-17
Quarterly	2019-06-30	119300000.0	-0.3%	shares	10-Q	2020-07-23
Quarterly	2019-09-30	119300000.0	+0.0%	shares	10-Q	2020-10-19
Quarterly	2020-03-31	119800000.0	+0.4%	shares	10-Q	2021-04-21
Quarterly	2020-06-30	119700000.0	-0.1%	shares	10-Q	2021-07-21
Quarterly	2020-09-30	361900000.0	+202.3%	shares	10-Q	2021-10-20
Quarterly	2021-03-31	364000000.0	+0.6%	shares	10-Q	2022-04-22
Quarterly	2021-06-30	364900000.0	+0.2%	shares	10-Q	2022-07-22
Quarterly	2021-09-30	366800000.0	+0.5%	shares	10-Q	2022-10-21
Quarterly	2022-03-31	366700000.0	-0.0%	shares	10-Q	2023-04-20
Quarterly	2022-06-30	363900000.0	-0.8%	shares	10-Q	2023-07-24
Quarterly	2022-09-30	360500000.0	-0.9%	shares	10-Q	2023-10-20
Quarterly	2023-03-31	356000000.0	-1.2%	shares	10-Q	2024-04-19
Quarterly	2023-06-30	357300000.0	+0.4%	shares	10-Q	2024-07-19
Quarterly	2023-09-30	358200000.0	+0.3%	shares	10-Q	2024-10-18
Quarterly	2024-03-31	360500000.0	+0.6%	shares	10-Q	2025-04-23
Quarterly	2024-06-30	361000000.0	+0.1%	shares	10-Q	2025-07-23
Quarterly	2024-09-30	362700000.0	+0.5%	shares	10-Q	2025-10-22
Quarterly	2025-03-31	364600000.0	+0.5%	shares	10-Q	2025-04-23
Quarterly	2025-06-30	364100000.0	-0.1%	shares	10-Q	2025-07-23
Quarterly	2025-09-30	361800000.0	-0.6%	shares	10-Q	2025-10-22
Annual	2016-12-31	117900000.0	—	shares	10-K	2019-02-04
Annual	2017-12-31	116300000.0	-1.4%	shares	10-K	2020-02-07
Annual	2018-12-31	118800000.0	+2.1%	shares	10-K	2021-02-10
Annual	2019-12-31	358400000.0	+201.7%	shares	10-K	2022-02-03
Annual	2020-12-31	361000000.0	+0.7%	shares	10-K	2023-02-10
Annual	2021-12-31	365800000.0	+1.3%	shares	10-K	2024-01-31
Annual	2022-12-31	362000000.0	-1.0%	shares	10-K	2025-01-31
Annual	2023-12-31	357400000.0	-1.3%	shares	10-K	2026-02-03
Annual	2024-12-31	362000000.0	+1.3%	shares	10-K	2026-02-03
Annual	2025-12-31	362700000.0	+0.2%	shares	10-K	2026-02-03

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

N/A

Total Liabilities (latest annual)

2,517,000,000

Current Liabilities (latest annual)

2,006,200,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	0.0287	—	ratio	10-Q	2017-04-19
Quarterly	2016-06-30	0.0356	+24.0%	ratio	10-Q	2017-07-21
Quarterly	2016-09-30	0.0381	+6.9%	ratio	10-Q	2017-10-20
Quarterly	2017-03-31	0.0438	+15.0%	ratio	10-Q	2018-04-18
Quarterly	2017-06-30	0.0493	+12.6%	ratio	10-Q	2018-07-20
Quarterly	2017-09-30	0.0602	+22.1%	ratio	10-Q	2018-10-22
Quarterly	2018-03-31	0.0522	-13.3%	ratio	10-Q	2019-04-19
Quarterly	2018-06-30	0.0434	-16.9%	ratio	10-Q	2019-07-22
Quarterly	2018-09-30	0.0464	+7.0%	ratio	10-Q	2019-10-18
Quarterly	2019-03-31	0.0432	-6.9%	ratio	10-Q	2020-04-17
Quarterly	2019-06-30	0.0435	+0.7%	ratio	10-Q	2020-07-23
Quarterly	2019-09-30	0.0513	+18.0%	ratio	10-Q	2020-10-19
Quarterly	2020-03-31	0.0371	-27.7%	ratio	10-Q	2021-04-21
Quarterly	2020-06-30	0.0080	-78.4%	ratio	10-Q	2021-07-21
Quarterly	2020-09-30	0.0341	+326.0%	ratio	10-Q	2021-10-20
Quarterly	2021-03-31	0.0427	+25.2%	ratio	10-Q	2022-04-22
Quarterly	2021-06-30	0.0481	+12.6%	ratio	10-Q	2022-07-22
Quarterly	2021-09-30	0.0338	-29.7%	ratio	10-Q	2022-10-21
Quarterly	2022-03-31	0.0304	-10.1%	ratio	10-Q	2023-04-20
Quarterly	2022-06-30	0.0260	-14.6%	ratio	10-Q	2023-07-24
Quarterly	2022-09-30	0.0281	+8.1%	ratio	10-Q	2023-10-20
Quarterly	2023-03-31	0.0319	+13.9%	ratio	10-Q	2024-04-19
Quarterly	2023-06-30	0.0356	+11.5%	ratio	10-Q	2024-07-19
Quarterly	2023-09-30	0.0333	-6.6%	ratio	10-Q	2024-10-18
Quarterly	2024-03-31	0.0390	+17.2%	ratio	10-Q	2025-04-23
Quarterly	2024-06-30	0.0359	-7.8%	ratio	10-Q	2025-07-23
Quarterly	2024-09-30	0.0364	+1.3%	ratio	10-Q	2025-10-22
Quarterly	2025-03-31	0.0409	+12.4%	ratio	10-Q	2025-04-23
Quarterly	2025-06-30	0.0370	-9.5%	ratio	10-Q	2025-07-23
Quarterly	2025-09-30	0.0416	+12.5%	ratio	10-Q	2025-10-22
Annual	2016-12-31	0.1268	—	ratio	10-K	2019-02-04
Annual	2017-12-31	0.1403	+10.6%	ratio	10-K	2020-02-07
Annual	2018-12-31	0.1682	+19.9%	ratio	10-K	2021-02-10
Annual	2019-12-31	0.1668	-0.9%	ratio	10-K	2022-02-03
Annual	2020-12-31	0.1093	-34.5%	ratio	10-K	2023-02-10
Annual	2021-12-31	0.1446	+32.3%	ratio	10-K	2024-01-31
Annual	2022-12-31	0.1210	-16.3%	ratio	10-K	2025-01-31
Annual	2023-12-31	0.1356	+12.1%	ratio	10-K	2026-02-03
Annual	2024-12-31	0.1414	+4.3%	ratio	10-K	2026-02-03
Annual	2025-12-31	0.1603	+13.4%	ratio	10-K	2026-02-03

8-K Material Event Details

45 filings · 95 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

1294 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-03-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	105	$0.00	$0	1,152
2026-03-10	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	105	$493.95	$51,865	0
2026-03-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	105	$229.39	$24,086	105
2026-03-09	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	645	$485.01	$312,831	1,613
2026-03-06	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	648	$490.19	$317,643	2,258
2026-03-05	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	648	$495.20	$320,890	2,906
2026-03-04	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	2,362	$498.68	$1,177,883	3,554
2026-03-03	Widman Fredrik	VP Corporate Controller	Open-market sell S	Common Stock	118	$487.18	$57,487	1,026
2026-03-03	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	4,728	$487.18	$2,303,387	409
2026-03-03	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	648	$488.10	$316,289	5,916
2026-03-02	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	125	$0.00	$0	0
2026-03-02	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	125	$492.59	$61,574	5,137
2026-03-02	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	125	$208.90	$26,112	5,262
2026-02-28	Widman Fredrik	VP Corporate Controller	Exercise / conversion M · derivative	Restricted Stock Units	468	$0.00	$0	0
2026-02-28	Widman Fredrik	VP Corporate Controller	Other disposed transaction F	Common Stock	233	$503.51	$117,318	1,144
2026-02-28	Widman Fredrik	VP Corporate Controller	Exercise / conversion M	Common Stock	468	$0.00	$0	1,377
2026-02-28	Jeddi Iman	SVP & GM da Vinci Platforms &	Exercise / conversion M · derivative	Restricted Stock Units - 2-28-2022	626	$0.00	$0	0
2026-02-28	Jeddi Iman	SVP & GM da Vinci Platforms &	Exercise / conversion M · derivative	Performance Stock Units - 2-28-2023	8,378	$0.00	$0	0
2026-02-28	Jeddi Iman	SVP & GM da Vinci Platforms &	Other disposed transaction F	Common Stock	4,155	$503.51	$2,092,084	6,463
2026-02-28	Jeddi Iman	SVP & GM da Vinci Platforms &	Exercise / conversion M	Common Stock	8,378	$0.00	$0	10,618
2026-02-28	Jeddi Iman	SVP & GM da Vinci Platforms &	Other disposed transaction F	Common Stock	311	$503.51	$156,592	2,240
2026-02-28	Jeddi Iman	SVP & GM da Vinci Platforms &	Exercise / conversion M	Common Stock	626	$0.00	$0	2,551
2026-02-27	WADORS PATRICIA L	SVP Chief Human Resources Offi	Open-market sell S	Common Stock	220	$499.71	$109,936	0
2026-02-27	Widman Fredrik	VP Corporate Controller	Open-market sell S	Common Stock	249	$499.71	$124,428	909
2026-02-26	WADORS PATRICIA L	SVP Chief Human Resources Offi	Equity grant / award A · derivative	Restricted Stock Units - 2-26-2026	3,584	$0.00	$0	3,584
2026-02-26	WADORS PATRICIA L	SVP Chief Human Resources Offi	Exercise / conversion M · derivative	Restricted Stock Units - 2-26-2025	458	$0.00	$0	1,373
2026-02-26	WADORS PATRICIA L	SVP Chief Human Resources Offi	Other disposed transaction F	Common Stock	238	$506.17	$120,468	220
2026-02-26	WADORS PATRICIA L	SVP Chief Human Resources Offi	Exercise / conversion M	Common Stock	458	$0.00	$0	458
2026-02-11	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	421	$494.96	$208,378	409
2026-02-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	838	$0.00	$0	838
2026-02-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	105	$0.00	$0	1,257
2026-02-10	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	105	$494.65	$51,938	830
2026-02-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	105	$229.39	$24,086	935
2026-02-10	Curet Myriam	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	417	$492.84	$205,514	830
2026-02-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	838	$0.00	$0	1,247
2026-01-29	Leonard Keith R	Dir	Other disposed transaction J	Common Stock	369	$0.00	$0	370
2026-01-28	Brosius Mark	SVP & Chief Mfg and Supply Cha	Equity grant / award A · derivative	Performance Stock Units - 2-28-2023	5,585	$0.00	$0	5,585
2026-01-28	Brosius Mark	SVP & Chief Mfg and Supply Cha	Equity grant / award A · derivative	Performance Stock Units - 2-26-2024	2,702	$0.00	$0	2,702
2026-01-27	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	105	$0.00	$0	1,362
2026-01-27	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	125	$0.00	$0	251
2026-01-27	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	125	$532.61	$66,576	0
2026-01-27	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	125	$208.90	$26,112	125
2026-01-27	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	105	$532.61	$55,924	0
2026-01-27	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	105	$229.39	$24,086	105
2025-12-15	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	464	$548.49	$254,499	443
2025-12-15	Brosius Mark	See Remarks	Open-market sell S	Common Stock	464	$548.49	$254,499	131
2025-12-12	Brosius Mark	SVP & Chief Mfg and Supply Cha	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	4,500	$0.00	$0	0
2025-12-12	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	4,500	$547.36	$2,463,120	907
2025-12-12	Brosius Mark	SVP & Chief Mfg and Supply Cha	Exercise / conversion M	Common Stock	4,500	$79.64	$358,370	5,407
2025-12-12	Brosius Mark	See Remarks	Open-market sell S	Common Stock	312	$547.36	$170,776	595
2025-12-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	104	$0.00	$0	1,467
2025-12-10	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	104	$559.90	$58,230	0
2025-12-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	104	$229.39	$23,857	104
2025-12-01	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	125	$0.00	$0	376
2025-12-01	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	125	$568.99	$71,124	0
2025-12-01	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	125	$208.90	$26,112	125
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	636	$0.00	$0	1,929
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,565	$0.00	$0	0
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,898	$0.00	$0	0
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,901	$0.00	$0	0
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	4,731	$580.00	$2,743,980	3,056
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	2,901	$580.00	$1,682,580	7,787
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	2,901	$177.99	$516,339	10,688
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	2,898	$580.00	$1,680,840	7,787
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	2,898	$242.34	$702,292	10,685
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	2,565	$580.00	$1,487,700	7,787
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	2,565	$245.60	$629,964	10,352
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	636	$580.00	$368,880	7,787
2025-11-12	Charlton Henry L	EVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	636	$347.42	$220,957	8,423
2025-11-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	105	$0.00	$0	1,571
2025-11-10	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	105	$560.00	$58,800	0
2025-11-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	105	$229.39	$24,086	105
2025-11-05	Widman Fredrik	VP Corporate Controller	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,908	$0.00	$0	0
2025-11-05	Widman Fredrik	VP Corporate Controller	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	159	$0.00	$0	0
2025-11-05	Widman Fredrik	VP Corporate Controller	Open-market sell S	Common Stock	159	$550.00	$87,450	473
2025-11-05	Widman Fredrik	VP Corporate Controller	Exercise / conversion M	Common Stock	159	$59.46	$9,454	632
2025-11-05	Widman Fredrik	VP Corporate Controller	Open-market sell S	Common Stock	1,908	$550.00	$1,049,400	473
2025-11-05	Widman Fredrik	VP Corporate Controller	Exercise / conversion M	Common Stock	1,908	$77.00	$146,914	2,381
2025-11-03	Rosa David J.	Chief Executive Officer (CEO)	Equity grant / award G	Common Stock	5,454	$0.00	$0	228,802
2025-10-29	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	125	$0.00	$0	501
2025-10-29	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	125	$543.00	$67,875	0
2025-10-29	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	125	$208.90	$26,112	125
2025-10-28	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	5,030	$0.00	$0	0
2025-10-28	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,153	$0.00	$0	1,676
2025-10-28	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,379	$0.00	$0	626
2025-10-28	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	1,379	$548.43	$756,279	353
2025-10-28	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	1,379	$208.90	$288,073	1,732
2025-10-28	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	1,153	$548.43	$632,334	353
2025-10-28	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	1,153	$229.39	$264,487	1,506
2025-10-28	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	5,030	$548.43	$2,758,580	353
2025-10-28	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	5,030	$242.34	$1,218,954	5,383
2025-10-24	GUTHART GARY S	Executive Chair of the Board o	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	36,000	$0.00	$0	0
2025-10-24	GUTHART GARY S	Executive Chair of the Board o	Open-market sell S	Common Stock	1,400	$546.18	$764,658	17,120
2025-10-24	GUTHART GARY S	Executive Chair of the Board o	Open-market sell S	Common Stock	28,800	$547.56	$15,769,644	27,027
2025-10-24	GUTHART GARY S	Executive Chair of the Board o	Exercise / conversion M	Common Stock	36,000	$109.49	$3,941,482	55,827
2025-10-10	LOEB GARY	EVP & Chief Legal and Complian	Exercise / conversion M · derivative	Restricted Stock Units	2,612	$0.00	$0	2,612
2025-10-10	LOEB GARY	EVP & Chief Legal and Complian	Other disposed transaction F	Common Stock	1,296	$443.76	$575,113	3,561
2025-10-10	LOEB GARY	EVP & Chief Legal and Complian	Exercise / conversion M	Common Stock	2,612	$0.00	$0	4,857
2025-09-04	Ladd Amy L	Dir	Open-market sell S	Common Stock	335	$440.69	$147,631	739
2025-09-03	Ladd Amy L	Dir	Open-market sell S	Common Stock	336	$470.11	$157,957	1,074
2025-08-29	GUTHART GARY S	Executive Chair of the Board o	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	36,000	$0.00	$0	0
2025-08-29	GUTHART GARY S	Executive Chair of the Board o	Open-market sell S	Common Stock	29,360	$472.49	$13,872,227	19,827
2025-08-29	GUTHART GARY S	Executive Chair of the Board o	Exercise / conversion M	Common Stock	36,000	$79.64	$2,866,961	49,187
2025-07-28	GUTHART GARY S	Executive Chair of the Board o	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,893	$0.00	$0	0
2025-07-28	GUTHART GARY S	Executive Chair of the Board o	Equity grant / award G	Common Stock	10,500	$0.00	$0	1,204,863
2025-07-28	GUTHART GARY S	Executive Chair of the Board o	Open-market sell S	Common Stock	1,400	$495.24	$693,337	18,520
2025-07-28	GUTHART GARY S	Executive Chair of the Board o	Open-market sell S	Common Stock	7,893	$498.64	$3,935,756	13,187
2025-07-28	GUTHART GARY S	Executive Chair of the Board o	Exercise / conversion M	Common Stock	7,893	$59.46	$469,335	21,080
2025-07-25	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	4,500	$0.00	$0	5,030
2025-07-25	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	4,500	$492.48	$2,216,160	353
2025-07-25	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	4,500	$242.34	$1,090,515	4,853
2025-07-10	Rosa David J.	Chief Executive Officer (CEO)	Equity grant / award A · derivative	Restricted Stock Units	7,640	$0.00	$0	7,640
2025-06-10	Rosa David J.	President	Exercise / conversion M · derivative	Restricted Stock Units - 6-12-23	1,358	$0.00	$0	2,716
2025-06-10	Rosa David J.	President	Other disposed transaction F	Common Stock	674	$526.15	$354,625	231,756
2025-06-10	Rosa David J.	President	Exercise / conversion M	Common Stock	1,358	$0.00	$0	232,430
2025-06-06	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	216	$563.11	$121,632	907
2025-06-05	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	215	$560.70	$120,550	1,123
2025-06-04	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	215	$552.07	$118,695	1,338
2025-06-04	Rosa David J.	President	Equity grant / award G	Common Stock	851	$0.00	$0	231,072
2025-06-03	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	215	$550.68	$118,396	1,553
2025-06-02	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	215	$549.06	$118,048	1,768
2025-05-16	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	20	$563.81	$11,276	1,983
2025-05-15	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	22	$560.00	$12,320	2,003
2025-05-14	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	22	$563.00	$12,386	2,025
2025-05-13	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	22	$561.67	$12,357	2,047
2025-05-12	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	22	$551.97	$12,143	2,069
2025-05-02	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	270	$0.00	$0	2,962
2025-05-02	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	269	$0.00	$0	2,963
2025-05-02	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	940
2025-05-02	Samath Jamie	See Remarks	Open-market sell S	Common Stock	915	$527.95	$483,074	7,162
2025-05-02	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	270	$304.67	$82,261	8,077
2025-05-02	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	269	$229.39	$61,706	7,619
2025-05-02	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	188	$290.33	$54,582	7,807
2025-05-01	Ladd Amy L	Dir	Equity grant / award A · derivative	Restricted Stock Units	531	$0.00	$0	531
2025-05-01	Reed Monica P	Dir	Equity grant / award A · derivative	Restricted Stock Units	531	$0.00	$0	531
2025-04-30	Ladd Amy L	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,709	$0.00	$0	0
2025-04-30	Ladd Amy L	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,671	$0.00	$0	0
2025-04-30	Ladd Amy L	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,448	$0.00	$0	0
2025-04-30	Ladd Amy L	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,650	$0.00	$0	0
2025-04-30	Ladd Amy L	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,298	$0.00	$0	0
2025-04-30	Ladd Amy L	Dir	Open-market sell S	Common Stock	1,709	$505.55	$863,978	1,410
2025-04-30	Ladd Amy L	Dir	Exercise / conversion M	Common Stock	1,709	$295.92	$505,727	3,119
2025-04-30	Ladd Amy L	Dir	Open-market sell S	Common Stock	1,650	$505.55	$834,151	1,410
2025-04-30	Ladd Amy L	Dir	Exercise / conversion M	Common Stock	1,650	$171.20	$282,480	3,060
2025-04-30	Ladd Amy L	Dir	Open-market sell S	Common Stock	2,298	$505.55	$1,161,744	1,410
2025-04-30	Ladd Amy L	Dir	Exercise / conversion M	Common Stock	2,298	$171.07	$393,126	3,708
2025-04-30	Ladd Amy L	Dir	Open-market sell S	Common Stock	1,671	$505.55	$844,767	1,410
2025-04-30	Ladd Amy L	Dir	Exercise / conversion M	Common Stock	1,671	$286.55	$478,831	3,081
2025-04-30	Ladd Amy L	Dir	Open-market sell S	Common Stock	1,448	$505.55	$732,030	1,410
2025-04-30	Ladd Amy L	Dir	Exercise / conversion M	Common Stock	1,448	$243.26	$352,240	2,858
2025-04-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	1,880
2025-04-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$512.90	$96,425	5,224
2025-04-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$208.90	$39,273	5,412
2025-04-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	1,880
2025-04-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$515.91	$96,991	5,224
2025-04-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$290.33	$54,582	5,412
2025-04-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	119	$0.00	$0	2,634
2025-04-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	2,068
2025-04-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	119	$513.18	$61,068	5,224
2025-04-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	119	$229.39	$27,297	5,343
2025-04-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$513.18	$96,478	5,224
2025-04-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$208.90	$39,273	5,412
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	479	$0.00	$0	2,753
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	597	$0.00	$0	0
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	480	$0.00	$0	2,753
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	564	$0.00	$0	2,256
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	4,557	$500.00	$2,278,500	5,224
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	3,707	$498.71	$1,848,718	9,781
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	480	$498.71	$239,381	13,488
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	480	$229.39	$110,107	13,968
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	479	$498.71	$238,882	13,488
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	479	$304.67	$145,937	13,967
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	597	$498.71	$297,730	13,488
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	597	$245.60	$146,623	14,085
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	564	$498.71	$281,272	13,488
2025-03-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	564	$208.90	$117,820	14,052
2025-03-12	Miller Brian Edward	EVP & Chief Digital Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,450	$0.00	$0	4,317
2025-03-12	Miller Brian Edward	EVP & Chief Digital Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,550	$0.00	$0	0
2025-03-12	Miller Brian Edward	EVP & Chief Digital Officer	Open-market sell S	Common Stock	2,450	$512.06	$1,254,547	5,758
2025-03-12	Miller Brian Edward	EVP & Chief Digital Officer	Exercise / conversion M	Common Stock	2,450	$208.90	$511,805	8,208
2025-03-12	Miller Brian Edward	EVP & Chief Digital Officer	Open-market sell S	Common Stock	1,550	$512.06	$793,693	5,758
2025-03-12	Miller Brian Edward	EVP & Chief Digital Officer	Exercise / conversion M	Common Stock	1,550	$177.99	$275,879	7,308
2025-03-11	Miller Brian Edward	EVP & Chief Digital Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,834	$0.00	$0	1,550
2025-03-11	Miller Brian Edward	EVP & Chief Digital Officer	Open-market sell S	Common Stock	6,624	$484.97	$3,212,449	5,758
2025-03-11	Miller Brian Edward	EVP & Chief Digital Officer	Open-market sell S	Common Stock	442	$482.82	$213,408	12,382
2025-03-11	Miller Brian Edward	EVP & Chief Digital Officer	Open-market sell S	Common Stock	1,834	$485.96	$891,245	12,824
2025-03-11	Miller Brian Edward	EVP & Chief Digital Officer	Exercise / conversion M	Common Stock	1,834	$177.99	$326,428	14,658
2025-03-07	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	489	$533.18	$260,725	2,091
2025-03-06	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	492	$558.95	$275,003	2,580
2025-03-05	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	492	$554.17	$272,652	3,072
2025-03-05	Rosa David J.	President	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	14,625	$0.00	$0	0
2025-03-05	Rosa David J.	President	Open-market sell S	Common Stock	8,140	$557.58	$4,538,691	231,923
2025-03-05	Rosa David J.	President	Open-market sell S	Common Stock	8,369	$557.47	$4,665,452	225,438
2025-03-05	Rosa David J.	President	Exercise / conversion M	Common Stock	14,625	$59.46	$869,635	240,063
2025-03-04	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	492	$563.69	$277,335	3,564
2025-03-03	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	492	$573.78	$282,300	4,056
2025-03-03	Widman Fredrik	VP Corporate Controller	Open-market sell S	Common Stock	810	$573.78	$464,762	473
2025-02-28	Brosius Mark	SVP & Chief Mfg and Supply Cha	Exercise / conversion M · derivative	Restricted Stock Units - 2-28-2022	877	$0.00	$0	877
2025-02-28	Brosius Mark	SVP & Chief Mfg and Supply Cha	Other disposed transaction F	Common Stock	2,175	$563.77	$1,226,200	4,548
2025-02-28	Brosius Mark	SVP & Chief Mfg and Supply Cha	Other disposed transaction F	Common Stock	435	$563.77	$245,240	6,723
2025-02-28	Brosius Mark	SVP & Chief Mfg and Supply Cha	Exercise / conversion M	Common Stock	877	$0.00	$0	7,158
2025-02-28	Widman Fredrik	VP Corporate Controller	Exercise / conversion M · derivative	Restricted Stock Units	468	$0.00	$0	468
2025-02-28	Widman Fredrik	VP Corporate Controller	Other disposed transaction F	Common Stock	233	$563.77	$131,358	1,283
2025-02-28	Widman Fredrik	VP Corporate Controller	Exercise / conversion M	Common Stock	468	$0.00	$0	1,516
2025-02-27	Brosius Mark	SVP & Chief Mfg and Supply Cha	Equity grant / award A	Common Stock	4,385	$0.00	$0	6,281
2025-02-26	Rosa David J.	President	Equity grant / award A · derivative	Restricted Stock Units - 2-26-2025	9,155	$0.00	$0	9,155
2025-02-26	Rosa David J.	President	Exercise / conversion M · derivative	Restricted Stock Units - 2-26-2024	3,816	$0.00	$0	11,447
2025-02-26	Rosa David J.	President	Exercise / conversion M · derivative	Restricted Stock Units	1,710	$0.00	$0	0
2025-02-26	Rosa David J.	President	Other disposed transaction F	Common Stock	1,892	$573.74	$1,085,516	214,635
2025-02-26	Rosa David J.	President	Exercise / conversion M	Common Stock	3,816	$0.00	$0	216,527
2025-02-26	Rosa David J.	President	Other disposed transaction F	Common Stock	848	$573.74	$486,532	212,711
2025-02-26	Rosa David J.	President	Exercise / conversion M	Common Stock	1,710	$0.00	$0	213,559
2025-02-12	LOEB GARY	EVP & Chief Legal and Complian	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,300	$0.00	$0	7,850
2025-02-12	LOEB GARY	EVP & Chief Legal and Complian	Open-market sell S	Common Stock	1,300	$583.79	$758,927	3,176
2025-02-12	LOEB GARY	EVP & Chief Legal and Complian	Exercise / conversion M	Common Stock	1,300	$186.55	$242,515	4,476
2025-02-11	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	408	$589.75	$240,618	353
2025-02-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	838	$0.00	$0	1,676
2025-02-10	Curet Myriam	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	430	$582.98	$250,681	761
2025-02-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	838	$0.00	$0	1,191
2025-01-29	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	94	$0.00	$0	1,222
2025-01-29	Samath Jamie	EVP & CFO & Enterprise Technol	Open-market sell S	Common Stock	94	$571.11	$53,684	2,630
2025-01-29	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M	Common Stock	94	$208.90	$19,637	2,724
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	135	$0.00	$0	3,366
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	1,222
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	105	$0.00	$0	54
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	134	$0.00	$0	3,367
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	94	$0.00	$0	1,316
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Open-market sell S	Common Stock	6,127	$575.00	$3,523,025	2,630
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Open-market sell S	Common Stock	94	$566.60	$53,260	8,757
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M	Common Stock	94	$208.90	$19,637	8,851
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Open-market sell S	Common Stock	134	$566.60	$75,924	8,757
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M	Common Stock	134	$229.39	$30,738	8,891
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Open-market sell S	Common Stock	135	$566.60	$76,491	8,757
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M	Common Stock	135	$304.67	$41,130	8,892
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Open-market sell S	Common Stock	105	$566.60	$59,493	8,757
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M	Common Stock	105	$245.60	$25,788	8,862
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Open-market sell S	Common Stock	188	$566.60	$106,521	8,757
2025-01-28	Samath Jamie	EVP & CFO & Enterprise Technol	Exercise / conversion M	Common Stock	188	$290.33	$54,582	8,945
2024-12-10	Samath Jamie	CFO and Head of Business Techn	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	135	$0.00	$0	3,501
2024-12-10	Samath Jamie	CFO and Head of Business Techn	Open-market sell S	Common Stock	135	$540.15	$72,921	8,757
2024-12-10	Samath Jamie	CFO and Head of Business Techn	Exercise / conversion M	Common Stock	135	$229.39	$30,968	8,892
2024-11-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	2,820
2024-11-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$539.00	$101,332	5,506
2024-11-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$208.90	$39,273	5,694
2024-11-26	Samath Jamie	CFO and Head of Business Techn	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	54	$0.00	$0	159
2024-11-26	Samath Jamie	CFO and Head of Business Techn	Open-market sell S	Common Stock	54	$542.06	$29,271	8,757
2024-11-26	Samath Jamie	CFO and Head of Business Techn	Exercise / conversion M	Common Stock	54	$245.60	$13,262	8,811
2024-11-22	Rosa David J.	President	Equity grant / award G	Common Stock	915	$0.00	$0	211,080
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,199	$0.00	$0	2,829
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	4,010	$0.00	$0	2,005
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	5,000	$0.00	$0	0
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,257	$0.00	$0	0
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	4,010	$535.96	$2,149,187	298
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	4,010	$208.90	$837,689	4,308
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	2,199	$535.96	$1,178,569	298
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	2,199	$229.39	$504,429	2,497
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	5,000	$535.96	$2,679,784	298
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	5,000	$182.83	$914,166	5,298
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	2,257	$535.96	$1,209,655	298
2024-11-12	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	2,257	$177.99	$401,716	2,555
2024-11-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	120	$0.00	$0	3,232
2024-11-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	119	$0.00	$0	3,233
2024-11-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	119	$539.89	$64,247	5,506
2024-11-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	119	$229.39	$27,297	5,625
2024-11-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	120	$539.89	$64,787	5,506
2024-11-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	120	$304.67	$36,560	5,626
2024-11-11	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	134	$0.00	$0	3,636
2024-11-11	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	135	$0.00	$0	3,636
2024-11-11	Samath Jamie	See Remarks	Open-market sell S	Common Stock	269	$539.89	$145,230	8,757
2024-11-11	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	135	$229.39	$30,968	9,026
2024-11-11	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	134	$304.67	$40,826	8,891
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,693	$0.00	$0	3,771
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,694	$0.00	$0	3,770
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	432	$0.00	$0	0
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,449	$0.00	$0	0
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,521	$0.00	$0	0
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,515	$0.00	$0	0
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,352	$0.00	$0	213
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,007	$0.00	$0	1,504
2024-11-08	Samath Jamie	See Remarks	Open-market sell S	Common Stock	22,903	$525.00	$12,024,075	8,757
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	2,693	$229.39	$617,747	28,653
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	2,694	$304.67	$820,781	25,960
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	432	$139.52	$60,273	23,266
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	1,449	$182.83	$264,925	22,402
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	1,521	$177.99	$270,718	19,504
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	1,515	$242.34	$367,140	17,983
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	2,352	$245.60	$577,651	16,468
2024-11-08	Samath Jamie	See Remarks	Exercise / conversion M	Common Stock	3,007	$208.90	$628,162	31,660
2024-11-05	Rosa David J.	President	Equity grant / award G	Common Stock	1,980	$0.00	$0	211,995
2024-10-30	GUTHART GARY S	CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	25,200	$0.00	$0	0
2024-10-30	GUTHART GARY S	CEO	Open-market sell S	Common Stock	3,720	$510.75	$1,900,003	19,920
2024-10-30	GUTHART GARY S	CEO	Open-market sell S	Common Stock	18,151	$511.63	$9,286,674	24,219
2024-10-30	GUTHART GARY S	CEO	Exercise / conversion M	Common Stock	25,200	$59.23	$1,492,541	42,370
2024-10-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	3,008
2024-10-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$506.52	$95,226	5,506
2024-10-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$208.90	$39,273	5,694
2024-10-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	3,008
2024-10-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	198	$0.00	$0	795
2024-10-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	198	$513.66	$101,705	5,506
2024-10-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	198	$245.60	$48,629	5,704
2024-10-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$513.66	$96,568	5,506
2024-10-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$290.33	$54,582	5,694
2024-10-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	198	$0.00	$0	993
2024-10-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	120	$0.00	$0	3,352
2024-10-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	3,196
2024-10-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	120	$514.00	$61,680	5,506
2024-10-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	120	$229.39	$27,527	5,626
2024-10-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	198	$514.00	$101,772	5,506
2024-10-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	198	$245.60	$48,629	5,704
2024-10-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$514.00	$96,632	5,506
2024-10-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$208.90	$39,273	5,694
2024-10-24	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	22	$510.79	$11,237	229
2024-10-23	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	22	$513.89	$11,306	251
2024-10-22	Brosius Mark	SVP & Chief Mfg and Supply Cha	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,106	$0.00	$0	0
2024-10-22	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	22	$515.00	$11,330	273
2024-10-22	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	2,106	$515.00	$1,084,590	295
2024-10-22	Brosius Mark	SVP & Chief Mfg and Supply Cha	Exercise / conversion M	Common Stock	2,106	$77.00	$162,160	2,401
2024-10-10	LOEB GARY	General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	2,613	$0.00	$0	5,224
2024-10-10	LOEB GARY	General Counsel	Other disposed transaction F	Common Stock	1,178	$490.38	$577,668	3,030
2024-10-10	LOEB GARY	General Counsel	Exercise / conversion M	Common Stock	2,613	$0.00	$0	4,208
2024-09-13	Ladd Amy L	Dir	Open-market sell S	Common Stock	450	$490.28	$220,626	821
2024-09-12	Brosius Mark	See Remarks	Exercise / conversion M · derivative	Non-Qualified Stock Option	2,115	$0.00	$0	0
2024-09-12	Brosius Mark	See Remarks	Open-market sell S	Common Stock	2,115	$491.91	$1,040,390	295
2024-09-12	Brosius Mark	See Remarks	Exercise / conversion M	Common Stock	2,115	$59.46	$125,763	2,410
2024-09-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	119	$0.00	$0	3,472
2024-09-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	119	$477.50	$56,822	5,506
2024-09-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	119	$229.39	$27,297	5,625
2024-09-09	LOEB GARY	General Counsel	Open-market sell S	Common Stock	300	$475.00	$142,500	1,595
2024-08-31	MOHR MARSHALL	Executive VP Global Business S	Other disposed transaction F	Common Stock	1,698	$492.63	$836,486	1,650
2024-08-31	MOHR MARSHALL	Executive VP Global Business S	Equity grant / award A	Common Stock	3,348	$0.00	$0	3,348
2024-08-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	3,384
2024-08-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$482.21	$90,655	5,506
2024-08-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$208.90	$39,273	5,694
2024-08-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	3,384
2024-08-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$482.93	$90,791	5,506
2024-08-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$290.33	$54,582	5,694
2024-08-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	198	$0.00	$0	1,191
2024-08-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	198	$486.88	$96,402	5,506
2024-08-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	198	$245.60	$48,629	5,704
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,336	$0.00	$0	0
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,414	$0.00	$0	1,336
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,625	$0.00	$0	0
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,750	$0.00	$0	0
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	422	$0.00	$0	0
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	5,203	$0.00	$0	422
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	468	$0.00	$0	0
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	456	$0.00	$0	0
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	459	$0.00	$0	0
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	6,829	$486.85	$3,324,684	3,001
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	6,828	$486.86	$3,324,290	9,830
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	459	$486.84	$223,458	23,486
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	459	$59.46	$27,293	23,945
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	456	$486.84	$221,998	23,486
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	456	$77.00	$35,112	23,942
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	468	$486.84	$227,840	23,486
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	468	$79.64	$37,270	23,954
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	422	$486.81	$205,435	23,486
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	422	$109.49	$46,203	23,908
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	5,203	$486.84	$2,533,015	23,486
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	5,203	$109.49	$569,654	28,689
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	3,750	$486.81	$1,825,544	23,486
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	3,750	$139.52	$523,200	27,236
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	1,336	$486.85	$650,429	23,486
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	1,336	$174.26	$232,807	24,822
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	2,414	$486.81	$1,175,163	23,486
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	2,414	$174.26	$420,656	25,900
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Open-market sell S	Common Stock	2,625	$486.85	$1,277,977	23,486
2024-08-23	Charlton Henry L	SVP & Chief Commercial and Mkt	Exercise / conversion M	Common Stock	2,625	$182.83	$479,937	26,111
2024-08-12	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	120	$0.00	$0	3,591
2024-08-12	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	120	$464.76	$55,771	5,506
2024-08-12	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	120	$229.39	$27,527	5,626
2024-08-01	Johnson Amal M	—	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,943	$0.00	$0	0
2024-08-01	Johnson Amal M	—	Open-market sell S	Common Stock	2,943	$443.30	$1,304,632	12,275
2024-08-01	Johnson Amal M	—	Exercise / conversion M	Common Stock	2,943	$71.32	$209,904	15,218
2024-07-30	GUTHART GARY S	CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	25,200	$0.00	$0	0
2024-07-30	GUTHART GARY S	CEO	Open-market sell S	Common Stock	3,720	$445.12	$1,655,833	23,640
2024-07-30	GUTHART GARY S	CEO	Equity grant / award G	Common Stock	12,500	$0.00	$0	1,191,144
2024-07-30	GUTHART GARY S	CEO	Open-market sell S	Common Stock	23,388	$443.07	$10,362,516	17,170
2024-07-30	GUTHART GARY S	CEO	Exercise / conversion M	Common Stock	25,200	$57.11	$1,439,200	40,558
2024-07-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	3,572
2024-07-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$446.60	$83,961	5,506
2024-07-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$208.90	$39,273	5,694
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	3,760
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	399	$0.00	$0	1,389
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	120	$0.00	$0	3,711
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	187	$0.00	$0	3,760
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	187	$438.60	$82,018	5,506
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	187	$208.90	$39,064	5,693
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	120	$438.60	$52,632	5,506
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	120	$229.39	$27,527	5,626
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	399	$438.60	$175,001	5,506
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	399	$245.60	$97,994	5,905
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$438.60	$82,457	5,506
2024-07-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$290.33	$54,582	5,694
2024-07-23	BARRATT CRAIG H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,400	$0.00	$0	0
2024-07-23	BARRATT CRAIG H	Dir	Open-market sell S	Common Stock	1,400	$458.13	$641,382	0
2024-07-23	BARRATT CRAIG H	Dir	Exercise / conversion M	Common Stock	1,400	$56.97	$79,764	1,400
2024-06-12	BARRATT CRAIG H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,400	$0.00	$0	1,400
2024-06-12	BARRATT CRAIG H	Dir	Open-market sell S	Common Stock	1,400	$421.06	$589,484	0
2024-06-12	BARRATT CRAIG H	Dir	Exercise / conversion M	Common Stock	1,400	$56.97	$79,764	1,400
2024-06-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	119	$0.00	$0	3,831
2024-06-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	120	$0.00	$0	3,831
2024-06-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	120	$416.60	$49,992	5,506
2024-06-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	120	$229.39	$27,527	5,626
2024-06-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	119	$416.60	$49,575	5,506
2024-06-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	119	$304.67	$36,256	5,625
2024-06-05	BARRATT CRAIG H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,400	$0.00	$0	2,800
2024-06-05	BARRATT CRAIG H	Dir	Open-market sell S	Common Stock	1,400	$411.00	$575,400	0
2024-06-05	BARRATT CRAIG H	Dir	Exercise / conversion M	Common Stock	1,400	$56.97	$79,764	1,400
2024-06-03	BARRATT CRAIG H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,096	$0.00	$0	4,200
2024-06-03	BARRATT CRAIG H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,400	$0.00	$0	5,296
2024-06-03	BARRATT CRAIG H	Dir	Open-market sell S	Common Stock	1,096	$402.89	$441,567	0
2024-06-03	BARRATT CRAIG H	Dir	Exercise / conversion M	Common Stock	1,096	$56.97	$62,444	1,096
2024-06-03	BARRATT CRAIG H	Dir	Open-market sell S	Common Stock	1,400	$402.89	$564,046	0
2024-06-03	BARRATT CRAIG H	Dir	Exercise / conversion M	Common Stock	1,400	$56.97	$79,764	1,400
2024-05-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	3,947
2024-05-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$396.59	$74,559	5,506
2024-05-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$208.90	$39,273	5,694
2024-05-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	3,948
2024-05-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	198	$0.00	$0	1,788
2024-05-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	198	$404.41	$80,073	5,506
2024-05-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	198	$245.60	$48,629	5,704
2024-05-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$404.41	$76,029	5,506
2024-05-28	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$290.33	$54,582	5,694
2024-05-17	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	63	$396.19	$24,960	295
2024-05-17	Rosa David J.	President	Equity grant / award G	Common Stock	2,507	$0.00	$0	215,285
2024-05-16	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	175	$398.28	$69,699	358
2024-05-15	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	175	$387.22	$67,764	533
2024-05-14	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	175	$380.85	$66,649	708
2024-05-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	90	$0.00	$0	0
2024-05-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	194	$389.16	$75,497	5,506
2024-05-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	90	$389.16	$35,024	5,700
2024-05-13	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	90	$179.70	$16,173	5,790
2024-05-13	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	175	$389.16	$68,103	883
2024-05-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Restricted Stock Units	360	$0.00	$0	0
2024-05-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Other disposed transaction F	Common Stock	167	$386.70	$64,579	5,700
2024-05-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	360	$0.00	$0	5,867
2024-05-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	120	$0.00	$0	3,950
2024-05-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	119	$0.00	$0	3,951
2024-05-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	119	$385.55	$45,880	5,507
2024-05-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	119	$229.39	$27,297	5,626
2024-05-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	120	$385.55	$46,266	5,507
2024-05-10	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	120	$304.67	$36,560	5,627
2024-05-03	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,709	$0.00	$0	0
2024-05-03	RUBASH MARK J	Dir	Open-market sell S	Common Stock	1,709	$380.00	$649,420	16,051
2024-05-03	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	1,709	$295.92	$505,727	17,760
2024-04-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	4,136
2024-04-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$375.39	$70,573	5,507
2024-04-29	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$208.90	$39,273	5,695
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	396	$0.00	$0	1,986
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	120	$0.00	$0	4,070
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	188	$0.00	$0	4,324
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	90	$0.00	$0	90
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	120	$368.10	$44,172	5,507
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	120	$229.39	$27,527	5,627
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	90	$368.10	$33,129	5,507
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	90	$179.70	$16,173	5,597
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	396	$368.10	$145,768	5,507
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	396	$245.60	$97,258	5,903
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	188	$368.10	$69,203	5,507
2024-04-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	188	$208.90	$39,273	5,695
2024-04-25	RUBASH MARK J	Dir	Equity grant / award A · derivative	Restricted Stock Units	739	$0.00	$0	739
2024-04-25	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Restricted Stock Units	569	$0.00	$0	0
2024-04-25	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	569	$0.00	$0	16,051
2024-04-23	LEVY ALAN J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,000	$0.00	$0	916
2024-04-23	LEVY ALAN J	Dir	Open-market sell S	Common Stock	2,000	$370.70	$741,398	25,319
2024-04-23	LEVY ALAN J	Dir	Exercise / conversion M	Common Stock	2,000	$154.24	$308,473	27,319
2024-03-15	Widman Fredrik	VP Corporate Controller	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	612	$0.00	$0	0
2024-03-15	Widman Fredrik	VP Corporate Controller	Open-market sell S	Common Stock	612	$397.07	$243,007	110
2024-03-15	Widman Fredrik	VP Corporate Controller	Exercise / conversion M	Common Stock	612	$59.23	$36,247	722
2024-03-15	Widman Fredrik	VP Corporate Controller	Open-market sell S	Common Stock	3,817	$397.07	$1,515,616	110
2024-03-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	119	$0.00	$0	4,190
2024-03-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	120	$0.00	$0	4,190
2024-03-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	90	$0.00	$0	180
2024-03-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	120	$390.16	$46,819	5,507
2024-03-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	120	$229.39	$27,527	5,627
2024-03-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	119	$390.16	$46,429	5,507
2024-03-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	119	$304.67	$36,256	5,626
2024-03-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	90	$390.16	$35,114	5,507
2024-03-11	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	90	$179.70	$16,173	5,597
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,149	$0.00	$0	2,382
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,437	$0.00	$0	4,309
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,504	$0.00	$0	4,512
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	993	$0.00	$0	2,382
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,436	$0.00	$0	4,310
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	940	$0.00	$0	4,511
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	363	$0.00	$0	270
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	453	$0.00	$0	0
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	2,749	$393.83	$1,082,641	5,507
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	2,819	$393.79	$1,110,106	8,256
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	940	$393.82	$370,187	11,075
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	940	$208.90	$196,366	12,015
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	1,436	$393.82	$565,520	11,075
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	1,436	$229.39	$329,404	12,511
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	1,437	$393.80	$565,893	11,075
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	1,437	$304.67	$437,811	12,512
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	363	$393.80	$142,948	11,075
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	363	$179.70	$65,231	11,438
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	453	$393.80	$178,390	11,075
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	453	$177.99	$80,628	11,528
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	993	$393.80	$391,046	11,075
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	993	$245.60	$243,881	12,068
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	7,149	$393.77	$2,815,097	11,075
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	7,149	$347.42	$2,483,682	18,224
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	1,504	$393.81	$592,287	11,075
2024-03-08	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	1,504	$290.33	$436,656	12,579
2024-03-07	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	196	$393.30	$77,087	1,450
2024-03-06	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	196	$386.76	$75,805	1,646
2024-03-05	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	196	$400.00	$78,400	1,842
2024-03-01	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	1,605	$383.48	$615,485	298
2024-02-29	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M · derivative	Restricted Stock Units	1,003	$0.00	$0	2,004
2024-02-29	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M · derivative	Restricted Stock Units	2,253	$0.00	$0	0
2024-02-29	MOHR MARSHALL	Executive VP Global Business S	Other disposed transaction F	Common Stock	509	$386.59	$196,774	49,502
2024-02-29	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M	Common Stock	1,003	$0.00	$0	50,011
2024-02-29	MOHR MARSHALL	Executive VP Global Business S	Other disposed transaction F	Common Stock	1,142	$386.59	$441,486	49,008
2024-02-29	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M	Common Stock	2,253	$0.00	$0	50,150
2024-02-29	GUTHART GARY S	CEO	Exercise / conversion M · derivative	Restricted Stock Units	2,506	$0.00	$0	5,012
2024-02-29	GUTHART GARY S	CEO	Exercise / conversion M · derivative	Restricted Stock Units	3,864	$0.00	$0	0
2024-02-29	GUTHART GARY S	CEO	Other disposed transaction F	Common Stock	1,271	$386.59	$491,356	15,358
2024-02-29	GUTHART GARY S	CEO	Exercise / conversion M	Common Stock	2,506	$0.00	$0	16,629
2024-02-29	GUTHART GARY S	CEO	Other disposed transaction F	Common Stock	1,959	$386.59	$757,330	14,123
2024-02-29	GUTHART GARY S	CEO	Exercise / conversion M	Common Stock	3,864	$0.00	$0	16,082
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	13,530	$0.00	$0	0
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	10,500	$0.00	$0	0
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	12,750	$0.00	$0	0
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	22,500	$0.00	$0	0
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	11,250	$0.00	$0	0
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Open-market sell S	Common Stock	6,860	$385.08	$2,641,659	47,897
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M	Common Stock	11,250	$77.00	$866,238	54,757
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Open-market sell S	Common Stock	13,750	$385.08	$5,294,842	43,507
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Open-market sell S	Common Stock	14,620	$385.09	$5,630,044	34,757
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M	Common Stock	22,500	$79.64	$1,791,850	57,257
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Open-market sell S	Common Stock	12,750	$385.08	$4,909,776	26,877
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M	Common Stock	12,750	$139.52	$1,778,880	39,627
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Open-market sell S	Common Stock	10,500	$385.08	$4,043,345	47,897
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M	Common Stock	10,500	$182.83	$1,919,750	58,397
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Open-market sell S	Common Stock	13,530	$385.08	$5,210,139	26,877
2024-02-28	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M	Common Stock	13,530	$177.99	$2,408,160	40,407
2024-02-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Equity grant / award A · derivative	Restricted Stock Units - 2-26-2024	6,105	$0.00	$0	6,105
2024-02-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Restricted Stock Units	1,587	$0.00	$0	1,587
2024-02-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Other disposed transaction F	Common Stock	498	$389.77	$194,105	9,099
2024-02-26	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	1,587	$0.00	$0	9,597
2024-02-16	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	32	$378.29	$12,105	709
2024-02-15	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	30	$382.03	$11,461	741
2024-02-15	Leonard Keith R	Dir	Equity grant / award G	Common Stock	2,547	$0.00	$0	1,037
2024-02-14	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	30	$380.09	$11,403	771
2024-02-13	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	30	$375.50	$11,265	801
2024-02-12	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	30	$386.09	$11,583	831
2024-02-12	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	481	$386.09	$185,709	298
2024-02-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	838	$0.00	$0	2,514
2024-02-10	Curet Myriam	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	357	$388.22	$138,595	779
2024-02-10	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	838	$0.00	$0	1,136
2024-02-07	Rosa David J.	President	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	22,050	$0.00	$0	0
2024-02-07	Rosa David J.	President	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	28,125	$0.00	$0	0
2024-02-07	Rosa David J.	President	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	40,500	$0.00	$0	0
2024-02-07	Rosa David J.	President	Open-market sell S	Common Stock	15,700	$389.29	$6,111,784	214,389
2024-02-07	Rosa David J.	President	Open-market sell S	Common Stock	23,120	$389.28	$9,000,195	201,964
2024-02-07	Rosa David J.	President	Exercise / conversion M	Common Stock	40,500	$49.09	$1,988,100	225,084
2024-02-07	Rosa David J.	President	Open-market sell S	Common Stock	16,150	$389.23	$6,286,026	184,584
2024-02-07	Rosa David J.	President	Exercise / conversion M	Common Stock	28,125	$49.34	$1,387,780	230,089
2024-02-07	Rosa David J.	President	Open-market sell S	Common Stock	12,840	$389.30	$4,998,665	172,609
2024-02-07	Rosa David J.	President	Open-market sell S	Common Stock	12,900	$389.29	$5,021,798	163,399
2024-02-07	Rosa David J.	President	Exercise / conversion M	Common Stock	22,050	$57.11	$1,259,300	185,449
2024-02-01	Brosius Mark	SVP & Chief Mfg and Supply Cha	Open-market sell S	Common Stock	39	$378.41	$14,758	448
2024-01-29	GUTHART GARY S	CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	33,750	$0.00	$0	0
2024-01-29	GUTHART GARY S	CEO	Open-market sell S	Common Stock	2,480	$374.41	$928,537	27,360
2024-01-29	GUTHART GARY S	CEO	Open-market sell S	Common Stock	24,325	$376.06	$9,147,669	9,425
2024-01-29	GUTHART GARY S	CEO	Exercise / conversion M	Common Stock	33,750	$51.02	$1,721,776	33,750
2024-01-26	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,500	$0.00	$0	7,500
2024-01-26	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,818	$0.00	$0	7,893
2024-01-26	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	1,500	$370.15	$555,222	189
2024-01-26	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	1,500	$182.83	$274,250	1,689
2024-01-26	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	2,818	$370.15	$1,043,076	189
2024-01-26	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	2,818	$177.99	$501,567	3,007
2023-12-13	Rosa David J.	President	Equity grant / award G	Common Stock	1,572	$0.00	$0	154,140
2023-11-16	Johnson Amal M	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,567	$0.00	$0	0
2023-11-16	Johnson Amal M	Dir	Open-market sell S	Common Stock	9,567	$300.00	$2,870,100	11,706
2023-11-16	Johnson Amal M	Dir	Exercise / conversion M	Common Stock	9,567	$41.26	$394,713	21,273
2023-11-14	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	597	$0.00	$0	3,375
2023-11-14	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	270	$0.00	$0	453
2023-11-14	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	270	$290.00	$78,300	7,259
2023-11-14	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	270	$242.34	$65,431	7,529
2023-11-14	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	597	$290.00	$173,130	7,259
2023-11-14	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	597	$245.60	$146,623	7,856
2023-11-10	Kolli Sreelakshmi	Dir	Equity grant / award A · derivative	Restricted Stock Units	240	$0.00	$0	240
2023-11-10	Kolli Sreelakshmi	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	722	$0.00	$0	722
2023-10-26	GUTHART GARY S	CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	33,750	$0.00	$0	0
2023-10-26	GUTHART GARY S	CEO	Open-market sell S	Common Stock	27,385	$260.11	$7,123,030	23,551
2023-10-26	GUTHART GARY S	CEO	Exercise / conversion M	Common Stock	33,750	$49.34	$1,665,336	50,936
2023-10-24	GUTHART GARY S	CEO	Open-market sell S	Common Stock	2,480	$271.93	$674,386	29,840
2023-10-10	LOEB GARY	General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	2,613	$0.00	$0	7,837
2023-10-10	LOEB GARY	General Counsel	Other disposed transaction F	Common Stock	904	$297.83	$269,238	1,709
2023-10-10	LOEB GARY	General Counsel	Exercise / conversion M	Common Stock	2,613	$0.00	$0	2,613
2023-09-14	Ladd Amy L	Dir	Open-market sell S	Common Stock	500	$305.68	$152,840	702
2023-08-10	MOHR MARSHALL	Executive VP Global Business S	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	2,873	$0.00	$0	2,873
2023-08-07	LEVY ALAN J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,535	$0.00	$0	3,928
2023-08-07	LEVY ALAN J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	465	$0.00	$0	0
2023-08-07	LEVY ALAN J	Dir	Open-market sell S	Common Stock	465	$310.00	$144,150	25,319
2023-08-07	LEVY ALAN J	Dir	Exercise / conversion M	Common Stock	465	$71.32	$33,165	25,784
2023-08-07	LEVY ALAN J	Dir	Open-market sell S	Common Stock	1,535	$310.00	$475,850	25,319
2023-08-07	LEVY ALAN J	Dir	Exercise / conversion M	Common Stock	1,535	$90.49	$138,909	26,854
2023-07-31	GUTHART GARY S	CEO	Open-market sell S	Common Stock	2,480	$325.89	$808,207	32,320
2023-07-28	GUTHART GARY S	CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	67,500	$0.00	$0	0
2023-07-28	GUTHART GARY S	CEO	Equity grant / award G	Common Stock	16,000	$0.00	$0	1,180,093
2023-07-28	GUTHART GARY S	CEO	Open-market sell S	Common Stock	50,314	$326.76	$16,440,733	17,186
2023-07-28	GUTHART GARY S	CEO	Exercise / conversion M	Common Stock	67,500	$42.64	$2,877,977	67,500
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	594	$0.00	$0	3,972
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	273	$0.00	$0	723
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	564	$0.00	$0	6,016
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	270	$0.00	$0	906
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	270	$322.76	$87,145	7,259
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	270	$177.99	$48,056	7,529
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	273	$322.76	$88,113	7,259
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	273	$242.34	$66,158	7,532
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	594	$322.76	$191,719	7,259
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	594	$245.60	$145,886	7,853
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Open-market sell S	Common Stock	564	$322.76	$182,037	7,259
2023-07-25	DeSantis Robert	EVP & Chief Strategy & Corp Op	Exercise / conversion M	Common Stock	564	$208.90	$117,820	7,823
2023-06-14	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	11,250	$0.00	$0	0
2023-06-14	MOHR MARSHALL	Executive VP Global Business S	Open-market sell S	Common Stock	11,250	$325.00	$3,656,250	24,136
2023-06-14	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M	Common Stock	11,250	$59.46	$668,950	35,386
2023-06-12	Rosa David J.	President	Equity grant / award A · derivative	Restricted Stock Units	5,433	$0.00	$0	5,433
2023-06-12	Rosa David J.	President	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	16,297	$0.00	$0	16,297
2023-05-11	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M · derivative	Restricted Stock Units	363	$0.00	$0	360
2023-05-11	DeSantis Robert	EVP & Chief Product Officer	Other disposed transaction F	Common Stock	169	$303.47	$51,286	7,259
2023-05-11	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M	Common Stock	363	$0.00	$0	7,428
2023-05-02	Curet Myriam	EVP & Chief Medical Officer	Equity grant / award G	Common Stock	138	$0.00	$0	189
2023-05-01	BARRATT CRAIG H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,000	$0.00	$0	1,567
2023-05-01	BARRATT CRAIG H	Dir	Open-market sell S	Common Stock	2,000	$306.00	$612,000	0
2023-05-01	BARRATT CRAIG H	Dir	Exercise / conversion M	Common Stock	2,000	$41.26	$82,516	2,000
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,671	$0.00	$0	0
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,448	$0.00	$0	0
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	707	$0.00	$0	0
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	688	$0.00	$0	0
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	895	$0.00	$0	0
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,391	$0.00	$0	0
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	523	$0.00	$0	0
2023-04-28	RUBASH MARK J	Dir	Open-market sell S	Common Stock	523	$300.00	$156,900	15,482
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	523	$71.32	$37,302	16,005
2023-04-28	RUBASH MARK J	Dir	Open-market sell S	Common Stock	1,391	$300.00	$417,300	15,482
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	1,391	$90.49	$125,878	16,873
2023-04-28	RUBASH MARK J	Dir	Open-market sell S	Common Stock	895	$300.00	$268,500	15,482
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	895	$154.24	$138,042	16,377
2023-04-28	RUBASH MARK J	Dir	Open-market sell S	Common Stock	707	$300.00	$212,100	15,482
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	707	$172.59	$122,023	16,189
2023-04-28	RUBASH MARK J	Dir	Open-market sell S	Common Stock	688	$300.00	$206,400	15,482
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	688	$171.07	$117,698	16,170
2023-04-28	RUBASH MARK J	Dir	Open-market sell S	Common Stock	1,671	$300.00	$501,300	15,482
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	1,671	$286.55	$478,831	17,153
2023-04-28	RUBASH MARK J	Dir	Open-market sell S	Common Stock	1,448	$300.00	$434,400	15,482
2023-04-28	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	1,448	$243.26	$352,240	16,930
2023-04-27	RUBASH MARK J	Dir	Equity grant / award A · derivative	Restricted Stock Units	569	$0.00	$0	569
2023-04-27	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Restricted Stock Units	482	$0.00	$0	0
2023-04-27	RUBASH MARK J	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	1,709	$0.00	$0	1,709
2023-04-27	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	482	$0.00	$0	15,482
2023-04-24	Rosa David J.	EVP Chief Strategy & Growth Of	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	54,000	$0.00	$0	0
2023-04-24	Rosa David J.	EVP Chief Strategy & Growth Of	Open-market sell S	Common Stock	40,764	$299.20	$12,196,446	155,712
2023-04-24	Rosa David J.	EVP Chief Strategy & Growth Of	Exercise / conversion M	Common Stock	54,000	$42.64	$2,302,382	196,476
2023-04-21	Rosa David J.	EVP Chief Strategy & Growth Of	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	54,000	$0.00	$0	54,000
2023-04-21	Rosa David J.	EVP Chief Strategy & Growth Of	Open-market sell S	Common Stock	40,800	$297.92	$12,155,173	142,476
2023-04-21	Rosa David J.	EVP Chief Strategy & Growth Of	Exercise / conversion M	Common Stock	54,000	$42.64	$2,302,382	183,276
2023-03-01	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	1,253	$228.47	$286,273	1,950
2023-02-28	Curet Myriam	EVP & Chief Medical Officer	Equity grant / award A · derivative	Restricted Stock Units	3,352	$0.00	$0	3,352
2023-02-28	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	1,003	$0.00	$0	3,007
2023-02-28	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	2,256	$0.00	$0	2,253
2023-02-28	Curet Myriam	EVP & Chief Medical Officer	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	5,028	$0.00	$0	5,028
2023-02-28	Curet Myriam	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	498	$229.39	$114,236	3,203
2023-02-28	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	1,003	$0.00	$0	3,701
2023-02-28	Curet Myriam	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	1,003	$229.39	$230,078	2,698
2023-02-28	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	2,256	$0.00	$0	3,701
2023-02-26	Widman Fredrik	VP Corporate Controller	Exercise / conversion M · derivative	Restricted Stock Units	609	$0.00	$0	1,215
2023-02-26	Widman Fredrik	VP Corporate Controller	Other disposed transaction F	Common Stock	212	$231.05	$48,983	2,002
2023-02-26	Widman Fredrik	VP Corporate Controller	Exercise / conversion M	Common Stock	609	$0.00	$0	2,214
2023-02-16	Widman Fredrik	VP Corporate Controller	Open-market sell S	Common Stock	116	$240.77	$27,929	1,605
2023-02-15	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M · derivative	Restricted Stock Units	1,749	$0.00	$0	0
2023-02-15	MOHR MARSHALL	Executive VP Global Business S	Other disposed transaction F	Common Stock	868	$244.77	$212,460	21,632
2023-02-15	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M	Common Stock	1,749	$0.00	$0	22,500
2023-02-13	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	54,000	$0.00	$0	0
2023-02-13	MOHR MARSHALL	Executive VP Global Business S	Open-market sell S	Common Stock	33,249	$245.61	$8,166,377	20,751
2023-02-13	MOHR MARSHALL	Executive VP Global Business S	Exercise / conversion M	Common Stock	54,000	$63.25	$3,415,262	54,000
2023-02-10	DiMartino Michele	See Remarks	Exercise / conversion M · derivative	Restricted Stock Units	987	$0.00	$0	2,960
2023-02-10	DiMartino Michele	See Remarks	Exercise / conversion M · derivative	Restricted Stock Units	1,504	$0.00	$0	0
2023-02-10	DiMartino Michele	See Remarks	Other disposed transaction F	Common Stock	298	$245.27	$73,090	2,112
2023-02-10	DiMartino Michele	See Remarks	Exercise / conversion M	Common Stock	987	—	—	2,410
2023-02-10	DiMartino Michele	See Remarks	Other disposed transaction F	Common Stock	478	$245.27	$117,239	1,423
2023-02-10	DiMartino Michele	See Remarks	Exercise / conversion M	Common Stock	1,504	—	—	1,901
2023-02-06	Rosa David J.	EVP Chief Strategy & Growth Of	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	54,000	$0.00	$0	0
2023-02-06	Rosa David J.	EVP Chief Strategy & Growth Of	Open-market sell S	Common Stock	45,025	$250.53	$11,280,023	125,385
2023-02-06	Rosa David J.	EVP Chief Strategy & Growth Of	Exercise / conversion M	Common Stock	54,000	$63.25	$3,415,262	170,410
2023-01-27	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	813	$0.00	$0	1,449
2023-01-27	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	816	$0.00	$0	1,269
2023-01-27	DeSantis Robert	EVP & Chief Product Officer	Open-market sell S	Common Stock	816	$250.00	$204,000	6,769
2023-01-27	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M	Common Stock	816	$177.99	$145,237	7,585
2023-01-27	DeSantis Robert	EVP & Chief Product Officer	Open-market sell S	Common Stock	813	$250.00	$203,250	6,769
2023-01-27	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M	Common Stock	813	$179.70	$146,096	7,582
2022-12-15	Rosa David J.	EVP Chief Strategy & Growth Of	Equity grant / award G	Common Stock	642	$0.00	$0	116,300
2022-11-08	Johnson Amal M	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	6,375	$0.00	$0	0
2022-11-08	Johnson Amal M	Dir	Open-market sell S	Common Stock	6,375	$239.36	$1,525,904	11,224
2022-11-08	Johnson Amal M	Dir	Exercise / conversion M	Common Stock	6,375	$53.76	$342,692	17,599
2022-11-01	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	6,000	$0.00	$0	6,000
2022-11-01	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,000	$0.00	$0	6,500
2022-11-01	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	6,000	$250.06	$1,500,382	217
2022-11-01	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	6,000	$174.26	$1,045,540	6,217
2022-11-01	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	2,000	$250.06	$500,127	217
2022-11-01	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	2,000	$166.62	$333,247	2,217
2022-10-21	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	67,500	$0.00	$0	0
2022-10-21	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	44,203	$210.84	$9,319,610	23,297
2022-10-21	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	67,500	$63.25	$4,269,078	67,500
2022-10-10	LOEB GARY	General Counsel & CCO	Equity grant / award A · derivative	Restricted Stock Units	10,450	$0.00	$0	10,450
2022-10-10	LOEB GARY	General Counsel and CCO	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	10,450	$0.00	$0	10,450
2022-09-08	Johnson Amal M	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	6,375	$0.00	$0	6,375
2022-09-08	Johnson Amal M	Dir	Open-market sell S	Common Stock	6,375	$210.76	$1,343,584	11,224
2022-09-08	Johnson Amal M	Dir	Exercise / conversion M	Common Stock	6,375	$53.76	$342,692	17,599
2022-08-29	Widman Fredrik	VP Corporate Controller	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	936	$0.00	$0	936
2022-08-15	Ladd Amy L	Dir	Open-market sell S	Common Stock	600	$237.03	$142,218	720
2022-08-03	Johnson Amal M	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	6,375	$0.00	$0	12,750
2022-08-03	Johnson Amal M	Dir	Open-market sell S	Common Stock	6,375	$238.04	$1,517,487	11,224
2022-08-03	Johnson Amal M	Dir	Exercise / conversion M	Common Stock	6,375	$53.76	$342,692	17,599
2022-07-27	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,000	$0.00	$0	0
2022-07-27	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	9,000	$225.00	$2,025,000	217
2022-07-27	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	9,000	$139.52	$1,255,680	9,217
2022-07-26	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	126,000	$0.00	$0	0
2022-07-26	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	79,412	$216.30	$17,177,054	54,607
2022-07-26	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	126,000	$57.48	$7,242,341	134,019
2022-05-11	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M · derivative	Restricted Stock Units	363	$0.00	$0	723
2022-05-11	DeSantis Robert	EVP & Chief Product Officer	Other disposed transaction F	Common Stock	169	$210.87	$35,637	6,768
2022-05-11	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M	Common Stock	363	$0.00	$0	6,937
2022-04-28	Ladd Amy L	Dir	Equity grant / award A · derivative	Restricted Stock Units	482	$0.00	$0	482
2022-04-28	Ladd Amy L	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	1,448	$0.00	$0	1,448
2022-04-26	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	795	$0.00	$0	6,750
2022-04-26	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	270	$0.00	$0	2,082
2022-04-26	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	273	$0.00	$0	2,262
2022-04-26	DeSantis Robert	EVP & Chief Product Officer	Open-market sell S	Common Stock	273	$253.04	$69,080	6,355
2022-04-26	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M	Common Stock	273	$177.99	$48,590	6,628
2022-04-26	DeSantis Robert	EVP & Chief Product Officer	Open-market sell S	Common Stock	270	$253.04	$68,321	6,355
2022-04-26	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M	Common Stock	270	$242.34	$65,431	6,625
2022-04-26	DeSantis Robert	EVP & Chief Product Officer	Open-market sell S	Common Stock	795	$253.04	$201,167	6,355
2022-04-26	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M	Common Stock	795	$245.60	$195,252	7,150
2022-04-22	Reed Monica P	Dir	Exercise / conversion M · derivative	Restricted Stock Units	555	$0.00	$0	0
2022-04-22	Reed Monica P	Dir	Exercise / conversion M	Common Stock	555	$0.00	$0	555
2022-02-28	MOHR MARSHALL	Executive Vice President Glob	Exercise / conversion M · derivative	Restricted Stock Units	2,256	$0.00	$0	4,509
2022-02-28	MOHR MARSHALL	Executive Vice President Glob	Other disposed transaction F	Common Stock	1,119	$290.33	$324,879	4,532
2022-02-28	MOHR MARSHALL	Executive Vice President Glob	Exercise / conversion M	Common Stock	2,256	$0.00	$0	5,651
2022-02-28	MOHR MARSHALL	Executive Vice President Glob	Equity grant / award A · derivative	Restricted Stock Units	4,010	$0.00	$0	4,010
2022-02-28	MOHR MARSHALL	Executive Vice President Glob	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	6,015	$0.00	$0	6,015
2022-02-26	MOHR MARSHALL	Executive Vice President Glob	Exercise / conversion M · derivative	Restricted Stock Units	1,713	$0.00	$0	5,130
2022-02-26	MOHR MARSHALL	Executive Vice President Glob	Other disposed transaction F	Common Stock	850	$293.51	$249,484	3,395
2022-02-26	MOHR MARSHALL	Executive Vice President Glob	Exercise / conversion M	Common Stock	1,713	$0.00	$0	4,245
2022-02-15	Charlton Henry L	Senior Vice President & Chief	Exercise / conversion M · derivative	Restricted Stock Units	1,311	$0.00	$0	1,311
2022-02-15	Charlton Henry L	Senior Vice President & Chief	Exercise / conversion M · derivative	Restricted Stock Units	1,875	$0.00	$0	0
2022-02-15	Charlton Henry L	Senior Vice President & Chief	Other disposed transaction F	Common Stock	395	$289.31	$114,277	15,655
2022-02-15	Charlton Henry L	Senior Vice President & Chief	Exercise / conversion M	Common Stock	1,311	$0.00	$0	16,050
2022-02-15	Charlton Henry L	Senior Vice President & Chief	Other disposed transaction F	Common Stock	577	$289.31	$166,932	14,739
2022-02-15	Charlton Henry L	Senior Vice President & Chief	Exercise / conversion M	Common Stock	1,875	$0.00	$0	15,316
2022-01-25	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,000	$0.00	$0	15,000
2022-01-25	Curet Myriam	EVP & Chief Medical Officer	Open-market sell S	Common Stock	3,000	$263.94	$791,826	285
2022-01-25	Curet Myriam	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	3,000	$109.49	$328,457	3,285
2021-12-14	Rosa David J.	EVP and Chief Business Officer	Equity grant / award G	Common Stock	250	$0.00	$0	111,953
2021-12-14	Rosa David J.	EVP and Chief Business Officer	Equity grant / award G	Common Stock	300	$0.00	$0	111,653
2021-11-24	Johnson Amal M	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,500	$0.00	$0	0
2021-11-24	Johnson Amal M	Dir	Open-market sell S	Common Stock	7,500	$333.73	$2,502,954	10,669
2021-11-24	Johnson Amal M	Dir	Exercise / conversion M	Common Stock	7,500	$64.36	$482,700	18,169
2021-11-10	Johnson Amal M	Dir	Equity grant / award G	Common Stock	500	$0.00	$0	10,669
2021-10-25	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	20,475	$0.00	$0	0
2021-10-25	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	20,475	$339.20	$6,945,122	0
2021-10-25	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	20,475	$59.23	$1,212,689	20,475
2021-10-22	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	156	$0.00	$0	1,515
2021-10-22	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	321	$0.00	$0	432
2021-10-22	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	273	$0.00	$0	1,449
2021-10-22	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	324	$0.00	$0	432
2021-10-22	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	324	$339.66	$110,048	762
2021-10-22	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	324	$139.52	$45,204	1,086
2021-10-22	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	321	$339.66	$109,029	762
2021-10-22	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	321	$174.26	$55,936	1,083
2021-10-22	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	273	$339.66	$92,726	762
2021-10-22	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	273	$182.83	$49,913	1,035
2021-10-22	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	156	$339.66	$52,986	762
2021-10-22	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	156	$177.99	$27,766	918
2021-09-09	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	400	$0.00	$0	581
2021-09-09	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	500	$0.00	$0	0
2021-09-09	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	232	$0.00	$0	0
2021-09-09	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	25	$0.00	$0	0
2021-09-09	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	39	$0.00	$0	0
2021-09-09	RUBASH MARK J	Dir	Open-market sell S	Common Stock	400	$1,083.16	$433,264	4,815
2021-09-09	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	400	$213.97	$85,588	5,215
2021-09-09	RUBASH MARK J	Dir	Open-market sell S	Common Stock	500	$1,083.16	$541,580	4,815
2021-09-09	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	500	$193.08	$96,540	5,315
2021-09-09	RUBASH MARK J	Dir	Open-market sell S	Common Stock	25	$1,083.16	$27,079	4,815
2021-09-09	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	25	$161.27	$4,032	4,840
2021-09-09	RUBASH MARK J	Dir	Open-market sell S	Common Stock	39	$1,083.16	$42,243	4,815
2021-09-09	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	39	$123.77	$4,827	4,854
2021-09-09	RUBASH MARK J	Dir	Open-market sell S	Common Stock	232	$1,083.16	$251,293	4,815
2021-09-09	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	232	$170.92	$39,654	5,047
2021-08-26	GUTHART GARY S	President & CEO	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	6,061	$0.00	$0	6,061
2021-08-11	Johnson Amal M	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	2,500
2021-08-11	Johnson Amal M	Dir	Open-market sell S	Common Stock	2,500	$1,001.63	$2,504,087	3,723
2021-08-11	Johnson Amal M	Dir	Exercise / conversion M	Common Stock	2,500	$193.08	$482,700	6,223
2021-08-06	Rosa David J.	EVP & Chief Business Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	10,500	$0.00	$0	0
2021-08-06	Rosa David J.	EVP & Chief Business Officer	Open-market sell S	Common Stock	8,065	$1,011.90	$8,160,977	37,501
2021-08-06	Rosa David J.	EVP & Chief Business Officer	Exercise / conversion M	Common Stock	10,500	$172.44	$1,810,585	45,566
2021-08-05	Rosa David J.	EVP & Chief Business Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	10,500	$0.00	$0	10,500
2021-08-05	Rosa David J.	EVP & Chief Business Officer	Open-market sell S	Common Stock	8,146	$1,007.23	$8,204,927	35,066
2021-08-05	Rosa David J.	EVP & Chief Business Officer	Exercise / conversion M	Common Stock	10,500	$172.44	$1,810,585	43,212
2021-08-03	Leonard Keith R	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	996	$0.00	$0	0
2021-08-03	Leonard Keith R	Dir	Open-market sell S	Common Stock	996	$1,000.00	$996,000	849
2021-08-03	Leonard Keith R	Dir	Exercise / conversion M	Common Stock	996	$462.71	$460,859	1,845
2021-07-26	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	6,825	$0.00	$0	0
2021-07-26	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	6,825	$963.38	$6,575,081	0
2021-07-26	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	6,825	$171.33	$1,169,350	6,825
2021-07-23	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	484	$0.00	$0	965
2021-07-23	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	422	$0.00	$0	1,026
2021-07-23	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	483	$0.00	$0	967
2021-07-23	DeSantis Robert	EVP & Chief Product Officer	Open-market sell S	Common Stock	2,615	$967.29	$2,529,453	363
2021-07-23	DeSantis Robert	EVP & Chief Product Officer	Open-market sell S	Common Stock	483	$967.23	$467,172	2,978
2021-07-23	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M	Common Stock	483	$533.96	$257,903	3,461
2021-07-23	DeSantis Robert	EVP & Chief Product Officer	Open-market sell S	Common Stock	422	$967.23	$408,171	2,978
2021-07-23	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M	Common Stock	422	$539.10	$227,500	3,400
2021-07-23	DeSantis Robert	EVP & Chief Product Officer	Open-market sell S	Common Stock	484	$967.21	$468,129	2,978
2021-07-23	DeSantis Robert	EVP & Chief Product Officer	Exercise / conversion M	Common Stock	484	$727.01	$351,873	3,462
2021-06-15	Rosa David J.	EVP and Chief Business Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	21,000	$0.00	$0	0
2021-06-15	Rosa David J.	EVP and Chief Business Officer	Open-market sell S	Common Stock	17,038	$873.23	$14,878,110	32,712
2021-06-15	Rosa David J.	EVP and Chief Business Officer	Exercise / conversion M	Common Stock	21,000	$168.41	$3,536,610	49,750
2021-05-12	Johnson Amal M	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	5,000
2021-05-12	Johnson Amal M	Dir	Open-market sell S	Common Stock	2,500	$817.82	$2,044,557	3,723
2021-05-12	Johnson Amal M	Dir	Exercise / conversion M	Common Stock	2,500	$193.08	$482,700	6,223
2021-05-04	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	14,000	$0.00	$0	0
2021-05-04	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	10,617	$851.99	$9,045,591	3,383
2021-05-04	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	14,000	$168.41	$2,357,740	14,000
2021-04-26	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	21,000	$0.00	$0	0
2021-04-26	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,375	$0.00	$0	0
2021-04-26	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	12,588	$865.74	$10,897,902	8,412
2021-04-26	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	21,000	$172.44	$3,621,171	21,000
2021-04-26	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	9,375	$865.63	$8,115,320	0
2021-04-26	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	9,375	$153.05	$1,434,813	9,375
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	227	$0.00	$0	610
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	90	$0.00	$0	665
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	52	$0.00	$0	612
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	108	$0.00	$0	359
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	91	$0.00	$0	664
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	107	$0.00	$0	360
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	59	$0.00	$0	0
2021-04-23	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	59	$848.01	$50,033	253
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	59	$238.91	$14,096	312
2021-04-23	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	107	$848.01	$90,737	253
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	107	$418.56	$44,786	360
2021-04-23	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	108	$848.01	$91,585	253
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	108	$522.77	$56,459	361
2021-04-23	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	90	$848.01	$76,321	253
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	90	$548.50	$49,365	343
2021-04-23	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	91	$848.01	$77,169	253
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	91	$499.87	$45,488	344
2021-04-23	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	52	$848.01	$44,097	253
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	52	$533.96	$27,766	305
2021-04-23	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	227	$850.00	$192,950	253
2021-04-23	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	227	$727.01	$165,031	480
2021-04-22	RUBASH MARK J	Dir	Equity grant / award A · derivative	Restricted Stock Units	185	$0.00	$0	185
2021-04-22	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Restricted Stock Units	255	$0.00	$0	0
2021-04-22	RUBASH MARK J	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	557	$0.00	$0	557
2021-04-22	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	255	$0.00	$0	4,815
2021-02-28	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Restricted Stock Units	1,289	$0.00	$0	3,865
2021-02-28	GUTHART GARY S	President & CEO	Other disposed transaction F	Common Stock	640	$0.00	$0	5,981
2021-02-28	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	1,289	$0.00	$0	6,621
2021-02-26	GUTHART GARY S	President & CEO	Equity grant / award A · derivative	Restricted Stock Units	4,040	$0.00	$0	4,040
2021-02-26	GUTHART GARY S	President & CEO	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	6,061	$0.00	$0	6,061
2021-02-17	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	1,485	$782.00	$1,161,270	94
2021-02-15	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	583	$0.00	$0	1,166
2021-02-15	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	1,000	$0.00	$0	1,000
2021-02-15	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Restricted Stock Units	999	$0.00	$0	0
2021-02-15	Myriam Curet	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	207	$0.00	$0	1,579
2021-02-15	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	583	$0.00	$0	1,786
2021-02-15	Myriam Curet	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	394	$0.00	$0	1,203
2021-02-15	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	1,000	$0.00	$0	1,597
2021-02-15	Myriam Curet	EVP & Chief Medical Officer	Other disposed transaction F	Common Stock	496	$0.00	$0	597
2021-02-15	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	999	$0.00	$0	1,093
2021-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Restricted Stock Units	583	$0.00	$0	3,499
2021-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Restricted Stock Units	708	$0.00	$0	708
2021-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Restricted Stock Units	1,250	$0.00	$0	0
2021-02-15	MOHR MARSHALL	Executive VP & CFO	Other disposed transaction F	Common Stock	620	$0.00	$0	9,840
2021-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	1,250	$172.44	$215,546	11,090
2021-02-15	MOHR MARSHALL	Executive VP & CFO	Other disposed transaction F	Common Stock	352	$0.00	$0	9,210
2021-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	708	$0.00	$0	9,562
2021-02-15	MOHR MARSHALL	Executive VP & CFO	Other disposed transaction F	Common Stock	290	$0.00	$0	8,854
2021-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	583	$0.00	$0	9,144
2021-02-11	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	21,000	$0.00	$0	0
2021-02-11	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	12,487	$800.00	$9,989,602	8,561
2021-02-11	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	21,000	$168.41	$3,536,610	21,048
2021-02-02	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	14,000	$0.00	$0	14,000
2021-02-02	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	11,020	$762.14	$8,398,759	2,980
2021-02-02	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	14,000	$168.41	$2,357,740	14,000
2021-01-29	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,375	$0.00	$0	0
2021-01-29	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	9,375	$751.66	$7,046,858	48
2021-01-29	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	9,375	$148.03	$1,387,781	9,423
2021-01-26	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	61	$0.00	$0	755
2021-01-26	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	18	$0.00	$0	664
2021-01-26	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	60	$0.00	$0	755
2021-01-26	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	72	$0.00	$0	467
2021-01-26	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	119	$0.00	$0	59
2021-01-26	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	119	$754.48	$89,783	207
2021-01-26	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	119	$238.91	$28,431	326
2021-01-26	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	72	$754.48	$54,323	207
2021-01-26	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	72	$418.56	$30,136	279
2021-01-26	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	61	$754.48	$46,023	207
2021-01-26	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	61	$548.50	$33,458	268
2021-01-26	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	60	$754.48	$45,269	207
2021-01-26	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	60	$499.87	$29,992	267
2021-01-26	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	18	$754.48	$13,581	207
2021-01-26	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	18	$533.96	$9,611	225
2020-12-09	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	2,900	$758.41	$2,199,394	11,600
2020-12-08	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	14,000	$0.00	$0	28,000
2020-12-08	GUTHART GARY S	President & CEO	Equity grant / award G	Common Stock	14,500	$0.00	$0	14,500
2020-12-08	GUTHART GARY S	President & CEO	Equity grant / award G	Common Stock	35,800	$0.00	$0	108,757
2020-12-08	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	11,114	$761.76	$8,466,228	252,197
2020-12-08	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	14,000	$168.41	$2,357,740	263,311
2020-12-07	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	156	$0.00	$0	682
2020-12-07	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	30	$0.00	$0	816
2020-12-07	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	36	$0.00	$0	539
2020-12-07	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	59	$0.00	$0	178
2020-12-07	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	60	$0.00	$0	178
2020-12-07	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	156	$778.00	$121,368	207
2020-12-07	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	156	$533.96	$83,298	363
2020-12-07	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	30	$778.00	$23,340	207
2020-12-07	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	30	$499.87	$14,996	237
2020-12-07	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	60	$778.00	$46,680	207
2020-12-07	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	60	$238.91	$14,335	267
2020-12-07	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	59	$778.00	$45,902	207
2020-12-07	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	59	$328.46	$19,379	266
2020-12-07	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	36	$778.00	$28,008	207
2020-12-07	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	36	$418.56	$15,068	243
2020-12-01	MOHR MARSHALL	Executive VP & CFO	Equity grant / award G	Common Stock	1,400	$0.00	$0	13,273
2020-10-26	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	6,000	$0.00	$0	0
2020-10-26	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	6,000	$715.28	$4,291,690	14,673
2020-10-26	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	6,000	$127.91	$767,460	20,673
2020-10-20	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	875	$0.00	$0	2,125
2020-10-20	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	875	$736.12	$644,105	2,986
2020-10-20	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	875	$238.91	$209,049	3,861
2020-09-10	Andersen Reiter Kara	Sr VP General Counsel & CCO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,250	$0.00	$0	3,250
2020-09-10	Andersen Reiter Kara	Sr VP General Counsel & CCO	Open-market sell S	Common Stock	264	$718.50	$189,684	4,068
2020-09-10	Andersen Reiter Kara	Sr VP General Counsel & CCO	Open-market sell S	Common Stock	1,250	$718.50	$898,125	4,332
2020-09-10	Andersen Reiter Kara	Sr VP General Counsel & CCO	Exercise / conversion M	Common Stock	1,250	$170.76	$213,446	5,582
2020-08-31	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,000	$0.00	$0	500
2020-08-31	RUBASH MARK J	Dir	Open-market sell S	Common Stock	1,000	$723.73	$723,730	4,560
2020-08-31	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	1,000	$193.08	$193,080	5,560
2020-08-28	MOHR MARSHALL	Executive VP & CFO	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	4,510	$0.00	$0	4,510
2020-08-25	Johnson Amal M	Dir	Equity grant / award G	Common Stock	6,000	$0.00	$0	3,468
2020-08-18	Myriam Curet	EVP & Chief Medical Officer	Equity grant / award G	Common Stock	80	$0.00	$0	2,986
2020-08-05	Rosa David J.	EVP and Chief Business Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	24,000	$0.00	$0	0
2020-08-05	Rosa David J.	EVP and Chief Business Officer	Open-market sell S	Common Stock	16,840	$693.02	$11,670,416	26,479
2020-08-05	Rosa David J.	EVP and Chief Business Officer	Exercise / conversion M	Common Stock	24,000	$113.73	$2,729,520	43,319
2020-07-27	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,500	$0.00	$0	6,000
2020-07-27	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	7,500	$677.19	$5,078,930	14,672
2020-07-27	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	7,500	$127.91	$959,325	22,172
2020-07-24	DeSantis Robert	Executive VP & GM IA&E	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	382	$0.00	$0	0
2020-07-24	DeSantis Robert	Executive VP & GM IA&E	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	383	$0.00	$0	0
2020-07-24	DeSantis Robert	Executive VP & GM IA&E	Open-market sell S	Common Stock	383	$665.57	$254,913	3,348
2020-07-24	DeSantis Robert	Executive VP & GM IA&E	Exercise / conversion M	Common Stock	383	$178.39	$68,322	3,731
2020-07-24	DeSantis Robert	Executive VP & GM IA&E	Open-market sell S	Common Stock	382	$665.57	$254,247	3,348
2020-07-24	DeSantis Robert	Executive VP & GM IA&E	Exercise / conversion M	Common Stock	382	$231.00	$88,241	3,730
2020-07-24	DeSantis Robert	Executive VP & GM IA&E	Open-market sell S	Common Stock	1,033	$666.69	$688,688	3,348
2020-07-21	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	90	$0.00	$0	937
2020-07-21	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	107	$0.00	$0	683
2020-07-21	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	91	$0.00	$0	936
2020-07-21	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	108	$0.00	$0	683
2020-07-21	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	178	$0.00	$0	415
2020-07-21	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	90	$663.33	$59,700	207
2020-07-21	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	90	$548.50	$49,365	297
2020-07-21	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	91	$663.33	$60,363	207
2020-07-21	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	91	$499.87	$45,488	298
2020-07-21	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	178	$663.33	$118,073	207
2020-07-21	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	178	$238.91	$42,527	385
2020-07-21	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	108	$663.33	$71,640	207
2020-07-21	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	108	$418.56	$45,204	315
2020-07-21	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	107	$663.33	$70,976	207
2020-07-21	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	107	$522.77	$55,936	314
2020-06-15	Rosa David J.	EVP and Chief Business Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	24,000	$0.00	$0	24,000
2020-06-15	Rosa David J.	EVP and Chief Business Officer	Open-market sell S	Common Stock	17,950	$553.49	$9,935,205	19,319
2020-06-15	Rosa David J.	EVP and Chief Business Officer	Exercise / conversion M	Common Stock	24,000	$113.73	$2,729,520	37,269
2020-06-05	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	91	$0.00	$0	1,027
2020-06-05	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	108	$0.00	$0	790
2020-06-05	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	90	$0.00	$0	1,027
2020-06-05	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	108	$600.00	$64,800	207
2020-06-05	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	108	$522.77	$56,459	315
2020-06-05	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	91	$600.00	$54,600	207
2020-06-05	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	91	$548.50	$49,914	298
2020-06-05	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	90	$600.00	$54,000	207
2020-06-05	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	90	$499.87	$44,988	297
2020-05-26	LEVY ALAN J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,950	$0.00	$0	3,600
2020-05-26	LEVY ALAN J	Dir	Open-market sell S	Common Stock	1,950	$575.00	$1,121,250	7,839
2020-05-26	LEVY ALAN J	Dir	Exercise / conversion M	Common Stock	1,950	$193.08	$376,506	9,789
2020-05-20	Johnson Amal M	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,000	$0.00	$0	0
2020-05-20	Johnson Amal M	Dir	Open-market sell S	Common Stock	3,000	$550.00	$1,650,000	9,468
2020-05-20	Johnson Amal M	Dir	Exercise / conversion M	Common Stock	3,000	$119.06	$357,190	12,468
2020-05-11	DeSantis Robert	Executive VP & GM IA&E	Equity grant / award A · derivative	Restricted Stock Units	483	$0.00	$0	483
2020-05-11	DeSantis Robert	Executive VP & GM IA&E	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	1,448	$0.00	$0	1,448
2020-05-05	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	31,875	$0.00	$0	0
2020-05-05	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	23,430	$510.38	$11,958,147	393,868
2020-05-05	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	31,875	$113.73	$3,625,144	417,298
2020-04-29	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	4,500	$0.00	$0	13,500
2020-04-29	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,000	$0.00	$0	0
2020-04-29	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	4,500	$525.00	$2,362,500	14,672
2020-04-29	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	4,500	$127.91	$575,595	19,172
2020-04-29	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	3,000	$525.00	$1,575,000	14,672
2020-04-29	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	3,000	$113.73	$341,190	17,672
2020-04-23	Beery Joseph C	Dir	Equity grant / award A · derivative	Restricted Stock Units	255	$0.00	$0	255
2020-04-23	Beery Joseph C	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	766	$0.00	$0	766
2020-04-22	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	750	$0.00	$0	3,000
2020-04-22	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,500	$0.00	$0	450
2020-04-22	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	1,500	$503.76	$755,640	3,066
2020-04-22	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	1,500	$189.74	$284,605	4,566
2020-04-22	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	750	$503.76	$377,820	3,066
2020-04-22	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	750	$231.00	$173,248	3,816
2020-04-21	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	178	$0.00	$0	594
2020-04-21	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	36	$0.00	$0	0
2020-04-21	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	34	$0.00	$0	0
2020-04-21	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	34	$506.18	$17,210	207
2020-04-21	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	34	$178.39	$6,065	241
2020-04-21	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	36	$506.18	$18,222	207
2020-04-21	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	36	$231.00	$8,316	243
2020-04-21	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	178	$506.18	$90,100	207
2020-04-21	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	178	$238.91	$42,527	385
2020-02-28	Myriam Curet	EVP & Chief Medical Officer	Equity grant / award A · derivative	Restricted Stock Units	3,007	$0.00	$0	3,007
2020-02-28	Myriam Curet	EVP & Chief Medical Officer	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	4,510	$0.00	$0	4,510
2020-02-16	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Restricted Stock Units	1,875	$0.00	$0	1,875
2020-02-16	MOHR MARSHALL	Executive VP & CFO	Other disposed transaction F	Common Stock	930	$0.00	$0	14,672
2020-02-16	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	1,875	$0.00	$0	15,602
2020-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Restricted Stock Units	584	$0.00	$0	4,082
2020-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Restricted Stock Units	708	$0.00	$0	0
2020-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Restricted Stock Units	1,250	$0.00	$0	0
2020-02-15	MOHR MARSHALL	Executive VP & CFO	Other disposed transaction F	Common Stock	290	$0.00	$0	13,727
2020-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	584	$0.00	$0	14,017
2020-02-15	MOHR MARSHALL	Executive VP & CFO	Other disposed transaction F	Common Stock	352	$0.00	$0	13,433
2020-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	708	$0.00	$0	13,785
2020-02-15	MOHR MARSHALL	Executive VP & CFO	Other disposed transaction F	Common Stock	620	$0.00	$0	13,077
2020-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	1,250	$0.00	$0	13,697
2020-02-14	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	12,537	$600.72	$7,531,240	298,523
2020-02-14	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	4,700	$0.00	$0	276,714
2020-02-14	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	15,663	$600.72	$9,409,095	281,414
2020-02-13	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	3,463	$600.30	$2,078,849	311,060
2020-02-13	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	1,300	$0.00	$0	297,077
2020-02-13	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	4,337	$600.30	$2,603,514	298,377
2020-02-13	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	332	$0.00	$0	1,118
2020-02-13	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	827	$0.00	$0	898
2020-02-13	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	333	$0.00	$0	1,117
2020-02-13	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	827	$600.00	$496,200	207
2020-02-13	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	827	$522.77	$432,331	1,034
2020-02-13	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	332	$600.00	$199,200	207
2020-02-13	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	332	$548.50	$182,102	539
2020-02-13	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	333	$600.00	$199,800	207
2020-02-13	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	333	$499.87	$166,457	540
2020-02-12	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	227	$592.78	$134,562	314,523
2020-02-05	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	31,875	$0.00	$0	31,875
2020-02-05	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	22,233	$576.56	$12,818,678	381,370
2020-02-05	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	31,875	$113.73	$3,625,144	403,603
2020-02-03	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,500	$0.00	$0	3,000
2020-02-03	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	7,500	$563.21	$4,224,056	12,447
2020-02-03	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	7,500	$113.73	$852,975	19,947
2020-01-29	LEVY ALAN J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,950	$0.00	$0	5,550
2020-01-29	LEVY ALAN J	Dir	Open-market sell S	Common Stock	1,950	$575.00	$1,121,250	7,577
2020-01-29	LEVY ALAN J	Dir	Exercise / conversion M	Common Stock	1,950	$193.08	$376,506	9,527
2020-01-28	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	9,179	$0.00	$0	314,750
2020-01-28	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	10,750	$0.00	$0	323,929
2020-01-28	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	13,012	$0.00	$0	334,679
2019-12-10	Rosa David J.	EVP and Chief Business Officer	Equity grant / award G	Common Stock	267	$0.00	$0	10,093
2019-12-09	GUTHART GARY S	President & CEO	Equity grant / award G	Common Stock	2,000	$0.00	$0	371,728
2019-12-06	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	59	$0.00	$0	890
2019-12-06	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	36	$0.00	$0	971
2019-12-06	Samath Jamie	SVP of Finance	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	35	$0.00	$0	105
2019-12-06	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	35	$584.63	$20,462	159
2019-12-06	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	35	$178.39	$6,244	194
2019-12-06	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	59	$584.63	$34,493	159
2019-12-06	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	59	$238.91	$14,096	218
2019-12-06	Samath Jamie	SVP of Finance	Open-market sell S	Common Stock	36	$584.63	$21,047	159
2019-12-06	Samath Jamie	SVP of Finance	Exercise / conversion M	Common Stock	36	$231.00	$8,316	195
2019-12-05	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	31,875	$0.00	$0	63,750
2019-12-05	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	22,377	$582.12	$13,026,084	373,728
2019-12-05	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	31,875	$113.73	$3,625,144	396,105
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	843	$0.00	$0	3,657
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,735	$0.00	$0	3,515
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	844	$0.00	$0	3,656
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,734	$0.00	$0	3,516
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,812	$0.00	$0	2,812
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	563	$0.00	$0	2,811
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	305	$0.00	$0	305
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	304	$0.00	$0	305
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	1,228	$592.00	$726,976	4,143
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	304	$586.66	$178,344	5,371
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	304	$178.39	$54,230	5,675
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	305	$586.66	$178,930	5,371
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	305	$231.00	$70,454	5,676
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	563	$586.66	$330,288	5,371
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	563	$238.91	$134,508	5,934
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	2,812	$586.66	$1,649,679	5,371
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	2,812	$328.46	$923,620	8,183
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	2,734	$586.66	$1,603,920	5,371
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	2,734	$418.56	$1,144,343	8,105
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	2,735	$586.69	$1,604,587	5,371
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	2,735	$522.77	$1,429,776	8,106
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	844	$586.69	$495,163	5,371
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	844	$499.87	$421,890	6,215
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	843	$586.69	$494,576	5,371
2019-12-02	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	843	$548.50	$462,386	6,214
2019-11-26	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	60,000	$0.00	$0	347,691
2019-11-19	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,000	$0.00	$0	1,500
2019-11-19	RUBASH MARK J	Dir	Open-market sell S	Common Stock	1,000	$580.00	$580,000	4,298
2019-11-19	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	1,000	$193.08	$193,080	5,298
2019-11-13	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	2,965	$0.00	$0	287,691
2019-11-13	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	84	$0.00	$0	290,656
2019-11-08	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	205	$554.49	$113,670	260,656
2019-11-04	Rosa David J.	EVP and Chief Business Officer	Equity grant / award G	Common Stock	1,884	$0.00	$0	10,360
2019-11-01	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	30,000	$0.00	$0	290,861
2019-10-31	Myriam Curet	EVP & Chief Medical Officer	Equity grant / award G	Common Stock	83	$0.00	$0	3,018
2019-10-28	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,500	$0.00	$0	10,500
2019-10-28	MOHR MARSHALL	Executive VP & CFO	Equity grant / award G	Common Stock	234	$0.00	$0	12,401
2019-10-28	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	7,500	$548.43	$4,113,258	12,635
2019-10-28	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	7,500	$113.73	$852,975	20,135
2019-10-23	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	743	$0.00	$0	260,861
2019-10-22	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	750	$0.00	$0	4,500
2019-10-22	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,500	$0.00	$0	3,450
2019-10-22	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	1,500	$553.92	$830,880	3,101
2019-10-22	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	1,500	$189.74	$284,605	4,601
2019-10-22	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	750	$553.92	$415,440	3,101
2019-10-22	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	750	$231.00	$173,248	3,851
2019-09-03	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	562	$0.00	$0	3,374
2019-09-03	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	304	$0.00	$0	610
2019-09-03	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	305	$0.00	$0	609
2019-09-03	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	305	$505.23	$154,095	5,371
2019-09-03	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	305	$178.39	$54,408	5,676
2019-09-03	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	304	$505.23	$153,590	5,371
2019-09-03	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	304	$231.00	$70,223	5,675
2019-09-03	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	562	$505.23	$283,939	5,371
2019-09-03	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	562	$238.91	$134,269	5,933
2019-08-20	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	215	$493.18	$106,034	261,604
2019-08-19	Samath Jamie	VP & Principal Accounting Offi	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	60	$0.00	$0	1,069
2019-08-19	Samath Jamie	VP & Principal Accounting Offi	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	35	$0.00	$0	212
2019-08-19	Samath Jamie	VP & Principal Accounting Offi	Open-market sell S	Common Stock	35	$503.50	$17,622	159
2019-08-19	Samath Jamie	VP & Principal Accounting Offi	Exercise / conversion M	Common Stock	35	$178.39	$6,244	194
2019-08-19	Samath Jamie	VP & Principal Accounting Offi	Open-market sell S	Common Stock	60	$503.50	$30,210	159
2019-08-19	Samath Jamie	VP & Principal Accounting Offi	Exercise / conversion M	Common Stock	60	$238.91	$14,335	219
2019-08-15	GUTHART GARY S	President & CEO	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	7,500	$0.00	$0	7,500
2019-08-02	Ladd Amy L	Dir	Equity grant / award A · derivative	Restricted Stock Units	183	$0.00	$0	183
2019-08-02	Ladd Amy L	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	550	$0.00	$0	550
2019-07-31	KANIA DON R	Dir	Exercise / conversion M · derivative	Restricted Stock Units	215	$0.00	$0	0
2019-07-31	KANIA DON R	Dir	Exercise / conversion M	Common Stock	215	$0.00	$0	215
2019-07-29	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,500	$0.00	$0	18,000
2019-07-29	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	7,500	$526.09	$3,945,640	12,635
2019-07-29	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	7,500	$113.73	$852,975	20,135
2019-07-24	Andersen Reiter Kara	Sr VP General Counsel & CCO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,000	$0.00	$0	6,000
2019-07-24	Andersen Reiter Kara	Sr VP General Counsel & CCO	Open-market sell S	Common Stock	1,120	$540.00	$604,800	3,718
2019-07-24	Andersen Reiter Kara	Sr VP General Counsel & CCO	Open-market sell S	Common Stock	3,000	$540.00	$1,620,000	4,838
2019-07-24	Andersen Reiter Kara	Sr VP General Counsel & CCO	Exercise / conversion M	Common Stock	3,000	$170.76	$512,270	7,838
2019-07-24	Andersen Reiter Kara	Sr VP General Counsel & CCO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,000	$0.00	$0	6,000
2019-07-24	Andersen Reiter Kara	Sr VP General Counsel & CCO	Open-market sell S	Common Stock	1,120	$540.00	$604,800	3,718
2019-07-24	Andersen Reiter Kara	Sr VP General Counsel & CCO	Open-market sell S	Common Stock	3,000	$540.00	$1,620,000	4,838
2019-07-24	Andersen Reiter Kara	Sr VP General Counsel & CCO	Exercise / conversion M	Common Stock	3,000	$170.76	$512,270	7,838
2019-07-23	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	15,943	$0.00	$0	283,546
2019-07-23	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	15,614	$0.00	$0	299,489
2019-07-23	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	14,000	$0.00	$0	261,819
2019-07-23	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	7,727	$0.00	$0	275,819
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,500	$0.00	$0	4,950
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	750	$0.00	$0	5,250
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	611	$0.00	$0	0
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	613	$0.00	$0	0
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	1,500	$532.14	$798,210	3,101
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	1,500	$189.74	$284,605	4,601
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	613	$532.14	$326,202	3,101
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	613	$171.33	$105,027	3,714
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	611	$532.14	$325,138	3,101
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	611	$177.68	$108,564	3,712
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	750	$532.14	$399,105	3,101
2019-07-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	750	$178.39	$133,790	3,851
2019-06-10	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	562	$0.00	$0	3,936
2019-06-10	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	305	$0.00	$0	914
2019-06-10	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	305	$500.60	$152,683	5,371
2019-06-10	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	305	$178.39	$54,408	5,676
2019-06-10	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	562	$500.60	$281,337	5,371
2019-06-10	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	562	$238.91	$134,269	5,933
2019-05-23	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	30,000	$0.00	$0	315,103
2019-05-16	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	227	$493.39	$112,000	286,275
2019-05-06	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	30,833	$0.00	$0	0
2019-05-06	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	22,636	$501.48	$11,351,596	364,230
2019-05-06	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	30,833	$111.43	$3,435,823	386,866
2019-04-25	LEVY ALAN J	Dir	Equity grant / award A · derivative	Restricted Stock Units	262	$0.00	$0	262
2019-04-25	LEVY ALAN J	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	786	$0.00	$0	786
2019-04-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,200	$0.00	$0	6,450
2019-04-23	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	2,200	$493.26	$1,085,179	3,101
2019-04-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	2,200	$189.74	$417,421	5,301
2019-04-23	Friedman Michael A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	996	$0.00	$0	0
2019-04-23	Friedman Michael A	Dir	Open-market sell S	Common Stock	996	$500.00	$498,000	4,751
2019-04-23	Friedman Michael A	Dir	Exercise / conversion M	Common Stock	996	$462.71	$460,859	5,747
2019-04-19	NACHTSHEIM JAMI K	Dir	Exercise / conversion M · derivative	Restricted Stock Units	332	$0.00	$0	0
2019-04-19	NACHTSHEIM JAMI K	Dir	Exercise / conversion M	Common Stock	332	$0.00	$0	845
2019-03-08	Myriam Curet	EVP & Chief Medical Officer	Equity grant / award G	Common Stock	41	$0.00	$0	3,101
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	563	$0.00	$0	4,498
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	305	$0.00	$0	1,219
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	458	$0.00	$0	0
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	459	$0.00	$0	0
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	459	$551.79	$253,273	5,371
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	459	$171.33	$78,642	5,830
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	458	$551.79	$252,721	5,371
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	458	$177.68	$81,379	5,829
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	305	$551.79	$168,297	5,371
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	305	$178.39	$54,408	5,676
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	563	$551.79	$310,659	5,371
2019-03-01	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	563	$238.91	$134,508	5,934
2019-02-26	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	210	$546.55	$114,777	286,502
2019-02-19	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	2,938	$543.51	$1,596,844	94
2019-02-15	Brogna Salvatore	EVP & Chief Operating Officer	Equity grant / award A · derivative	Restricted Stock Units	3,000	$0.00	$0	3,000
2019-02-15	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Restricted Stock Units	1,042	$0.00	$0	3,125
2019-02-15	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Restricted Stock Units	1,500	$0.00	$0	3,000
2019-02-15	Brogna Salvatore	EVP & Chief Operating Officer	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	4,500	$0.00	$0	4,500
2019-02-15	Brogna Salvatore	EVP & Chief Operating Officer	Other disposed transaction F	Common Stock	517	$0.00	$0	2,917
2019-02-15	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	1,042	$0.00	$0	3,434
2019-02-15	Brogna Salvatore	EVP & Chief Operating Officer	Other disposed transaction F	Common Stock	595	$0.00	$0	2,392
2019-02-15	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	1,500	$0.00	$0	2,987
2019-02-15	MOHR MARSHALL	Executive VP & CFO	Other disposed transaction F	Common Stock	972	$548.50	$533,142	10,626
2019-02-15	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	1,959	$0.00	$0	11,598
2019-02-06	Andersen Reiter Kara	Sr VP General Counsel & CCO	Exercise / conversion M · derivative	Restricted Stock Units	750	$0.00	$0	0
2019-02-06	Andersen Reiter Kara	Sr VP General Counsel & CCO	Other disposed transaction F	Common Stock	271	$521.95	$141,448	3,788
2019-02-06	Andersen Reiter Kara	Sr VP General Counsel & CCO	Exercise / conversion M	Common Stock	750	$0.00	$0	4,059
2019-02-05	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,500	$0.00	$0	33,000
2019-02-05	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	7,500	$525.00	$3,937,500	9,559
2019-02-05	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	7,500	$113.73	$852,975	17,059
2019-02-04	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	40,833	$0.00	$0	30,833
2019-02-04	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	28,152	$520.47	$14,652,190	351,300
2019-02-04	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	40,833	$111.43	$4,550,156	379,452
2019-01-29	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	10,071	$0.00	$0	286,712
2018-12-12	Rosa David J.	EVP & Chief Commercial Officer	Equity grant / award G	Common Stock	3,354	$0.00	$0	8,354
2018-12-03	GUTHART GARY S	President & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	40,834	$0.00	$0	71,666
2018-12-03	GUTHART GARY S	President & CEO	Equity grant / award G	Common Stock	2,000	$0.00	$0	338,619
2018-12-03	GUTHART GARY S	President & CEO	Open-market sell S	Common Stock	28,085	$542.78	$15,243,920	340,619
2018-12-03	GUTHART GARY S	President & CEO	Exercise / conversion M	Common Stock	40,834	$111.43	$4,550,267	368,704
2018-11-11	Myriam Curet	EVP & Chief Medical Officer	Equity grant / award G	Common Stock	40	$0.00	$0	1,900
2018-11-07	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	225	$540.04	$121,509	266,783
2018-11-05	MOHR MARSHALL	Executive VP & CFO	Equity grant / award G	Common Stock	262	$0.00	$0	9,559
2018-10-31	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	7,500	$0.00	$0	40,500
2018-10-31	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	7,500	$525.00	$3,937,500	9,821
2018-10-31	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	7,500	$113.73	$852,975	17,321
2018-10-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,100	$0.00	$0	8,650
2018-10-23	Myriam Curet	EVP & Chief Medical Officer	Open-market sell S	Common Stock	1,100	$498.28	$548,103	1,940
2018-10-23	Myriam Curet	EVP & Chief Medical Officer	Exercise / conversion M	Common Stock	1,100	$189.74	$208,710	3,040
2018-10-23	Johnson Amal M	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,000	$0.00	$0	7,250
2018-10-23	Johnson Amal M	Dir	Open-market sell S	Common Stock	1,000	$500.00	$500,000	8,874
2018-10-23	Johnson Amal M	Dir	Exercise / conversion M	Common Stock	1,000	$119.06	$119,063	9,874
2018-09-14	Myriam Curet	EVP & Chief Medical Officer	Equity grant / award G	Common Stock	30	$0.00	$0	1,940
2018-09-07	Friedman Michael A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,545	$0.00	$0	0
2018-09-07	Friedman Michael A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	525	$0.00	$0	0
2018-09-07	Friedman Michael A	Dir	Open-market sell S	Common Stock	525	$541.46	$284,266	4,419
2018-09-07	Friedman Michael A	Dir	Exercise / conversion M	Common Stock	525	$185.73	$97,510	4,944
2018-09-07	Friedman Michael A	Dir	Open-market sell S	Common Stock	1,545	$541.46	$836,554	4,419
2018-09-07	Friedman Michael A	Dir	Exercise / conversion M	Common Stock	1,545	$271.48	$419,442	5,964
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	562	$0.00	$0	5,624
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	563	$0.00	$0	5,623
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	304	$0.00	$0	1,829
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	305	$0.00	$0	1,828
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	459	$0.00	$0	917
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	459	$557.29	$255,796	1,487
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	459	$171.33	$78,642	1,946
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	305	$557.29	$169,973	1,487
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	305	$178.39	$54,408	1,792
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	304	$557.29	$169,416	1,487
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	304	$231.00	$70,223	1,791
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	563	$557.58	$313,918	1,487
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	563	$238.91	$134,508	2,050
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Open-market sell S	Common Stock	562	$557.48	$313,304	1,487
2018-09-04	Brogna Salvatore	EVP & Chief Operating Officer	Exercise / conversion M	Common Stock	562	$328.46	$184,593	2,049
2018-08-31	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	350	$0.00	$0	25
2018-08-31	RUBASH MARK J	Dir	Open-market sell S	Common Stock	350	$560.00	$196,000	3,966
2018-08-31	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	350	$161.27	$56,443	4,316
2018-08-30	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	19,857	$0.00	$0	267,008
2018-08-30	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	10,620	$0.00	$0	286,865
2018-08-27	RUBASH MARK J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	150	$0.00	$0	39
2018-08-27	RUBASH MARK J	Dir	Open-market sell S	Common Stock	150	$543.66	$81,549	3,966
2018-08-27	RUBASH MARK J	Dir	Exercise / conversion M	Common Stock	150	$123.77	$18,566	4,116
2018-08-22	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	20,000	$0.00	$0	368,555
2018-08-22	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	10,000	$0.00	$0	388,555
2018-08-15	Myriam Curet	EVP & Chief Medical Officer	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	6,000	$0.00	$0	6,000
2018-08-07	Rosa David J.	EVP & Chief Commercial Officer	Exercise / conversion M · derivative	Restricted Stock Units	1,125	$0.00	$0	0
2018-08-07	Rosa David J.	EVP & Chief Commercial Officer	Other disposed transaction F	Common Stock	558	$0.00	$0	11,708
2018-08-07	Rosa David J.	EVP & Chief Commercial Officer	Exercise / conversion M	Common Stock	1,125	$0.00	$0	12,266
2018-08-06	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	245	$521.18	$127,690	317,789
2018-08-01	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	6,861	$0.00	$0	297,730
2018-08-01	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	13,443	$0.00	$0	304,591
2018-07-31	KANIA DON R	Dir	Equity grant / award A · derivative	Restricted Stock Units	215	$0.00	$0	215
2018-07-31	KANIA DON R	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	647	$0.00	$0	647
2018-07-30	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	8,250	$0.00	$0	0
2018-07-30	MOHR MARSHALL	Executive VP & CFO	Open-market sell S	Common Stock	8,250	$508.50	$4,195,090	9,821
2018-07-30	MOHR MARSHALL	Executive VP & CFO	Exercise / conversion M	Common Stock	8,250	$111.43	$919,325	18,071
2018-07-24	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	6,000	$523.37	$3,140,227	318,034
2018-07-24	SMITH LONNIE M	Dir	Open-market sell S	Common Stock	50,000	$523.37	$26,168,560	378,251
2018-07-24	BARRATT CRAIG H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	0
2018-07-24	BARRATT CRAIG H	Dir	Open-market sell S	Common Stock	2,500	$522.00	$1,305,000	0
2018-07-24	BARRATT CRAIG H	Dir	Exercise / conversion M	Common Stock	2,500	$193.08	$482,700	2,500
2018-07-23	Friedman Michael A	Dir	Exercise / conversion M · derivative	Restricted Stock Units	975	$0.00	$0	0
2018-07-23	Friedman Michael A	Dir	Exercise / conversion M	Common Stock	975	$0.00	$0	4,419
2018-05-29	SMITH LONNIE M	Dir	Equity grant / award G	Common Stock	30,000	$0.00	$0	325,034

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count