Financial Metrics

JAZZ Jazz Pharmaceuticals plc

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	1.21	—	USD/shares	10-Q	2017-05-09
Quarterly	2016-06-30	1.85	+52.9%	USD/shares	10-Q	2017-08-08
Quarterly	2016-09-30	1.45	-21.6%	USD/shares	10-Q	2017-11-07
Quarterly	2017-03-31	1.41	-2.8%	USD/shares	10-Q	2018-05-08
Quarterly	2017-06-30	1.72	+22.0%	USD/shares	10-Q	2018-08-07
Quarterly	2017-09-30	1.03	-40.1%	USD/shares	10-Q	2018-11-06
Quarterly	2018-03-31	0.75	-27.2%	USD/shares	10-Q	2019-05-07
Quarterly	2018-06-30	1.5	+100.0%	USD/shares	10-Q	2019-08-06
Quarterly	2018-09-30	2.41	+60.7%	USD/shares	10-Q	2019-11-05
Quarterly	2019-03-31	1.47	-39.0%	USD/shares	10-Q	2020-05-05
Quarterly	2019-06-30	4.56	+210.2%	USD/shares	10-Q	2020-08-04
Quarterly	2019-09-30	1.78	-61.0%	USD/shares	10-Q	2020-11-02
Quarterly	2020-03-31	-2.82	-258.4%	USD/shares	10-Q	2021-05-04
Quarterly	2020-06-30	2.06	+173.0%	USD/shares	10-Q	2021-08-03
Quarterly	2020-09-30	2.64	+28.2%	USD/shares	10-Q	2021-11-09
Quarterly	2021-03-31	2.09	-20.8%	USD/shares	10-Q	2022-05-04
Quarterly	2021-06-30	-6.11	-392.3%	USD/shares	10-Q	2022-08-03
Quarterly	2021-09-30	-0.86	+85.9%	USD/shares	10-Q	2022-11-09
Quarterly	2022-03-31	0.03	+103.5%	USD/shares	10-Q	2023-05-10
Quarterly	2022-06-30	0.55	+1733.3%	USD/shares	10-Q	2023-08-09
Quarterly	2022-09-30	-0.31	-156.4%	USD/shares	10-Q	2023-11-08
Quarterly	2023-03-31	1.04	+435.5%	USD/shares	10-Q	2024-05-02
Quarterly	2023-06-30	1.52	+46.2%	USD/shares	10-Q	2024-08-01
Quarterly	2023-09-30	2.14	+40.8%	USD/shares	10-Q	2024-11-07
Quarterly	2024-03-31	-0.23	-110.7%	USD/shares	10-Q	2025-05-07
Quarterly	2024-06-30	2.49	+1182.6%	USD/shares	10-Q	2025-08-06
Quarterly	2024-09-30	3.42	+37.3%	USD/shares	10-Q	2025-11-05
Quarterly	2025-03-31	-1.52	-144.4%	USD/shares	10-Q	2025-05-07
Quarterly	2025-06-30	-11.74	-672.4%	USD/shares	10-Q	2025-08-06
Quarterly	2025-09-30	4.08	+134.8%	USD/shares	10-Q	2025-11-05
Annual	2016-12-31	6.41	—	USD/shares	10-K	2019-02-26
Annual	2017-12-31	7.96	+24.2%	USD/shares	10-K	2020-02-25
Annual	2018-12-31	7.3	-8.3%	USD/shares	10-K	2021-02-23
Annual	2019-12-31	9.09	+24.5%	USD/shares	10-K	2022-03-01
Annual	2020-12-31	4.22	-53.6%	USD/shares	10-K	2023-03-01
Annual	2021-12-31	-5.52	-230.8%	USD/shares	10-K	2024-02-28
Annual	2022-12-31	-3.58	+35.1%	USD/shares	10-K	2025-02-26
Annual	2023-12-31	6.1	+270.4%	USD/shares	10-K	2026-02-24
Annual	2024-12-31	8.65	+41.8%	USD/shares	10-K	2026-02-24
Annual	2025-12-31	-5.84	-167.5%	USD/shares	10-K	2026-02-24

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	1184025000.0	—	USD	10-Q	2016-05-10
Quarterly	2016-06-30	1179152000.0	-0.4%	USD	10-Q	2016-08-09
Quarterly	2016-09-30	2183473000.0	+85.2%	USD	10-Q	2016-11-08
Quarterly	2016-12-31	2029625000.0	-7.0%	USD	10-Q	2017-11-07
Quarterly	2017-03-31	1875688000.0	-7.6%	USD	10-Q	2017-05-09
Quarterly	2017-06-30	1671894000.0	-10.9%	USD	10-Q	2017-08-08
Quarterly	2017-09-30	1579913000.0	-5.5%	USD	10-Q	2017-11-07
Quarterly	2017-12-31	1581038000.0	+0.1%	USD	10-Q	2018-11-06
Quarterly	2018-03-31	1582161000.0	+0.1%	USD	10-Q	2018-05-08
Quarterly	2018-06-30	1591701000.0	+0.6%	USD	10-Q	2018-08-07
Quarterly	2018-09-30	1593969000.0	+0.1%	USD	10-Q	2018-11-06
Quarterly	2018-12-31	1596412000.0	+0.2%	USD	10-Q	2019-11-05
Quarterly	2019-03-31	1598664000.0	+0.1%	USD	10-Q	2019-05-07
Quarterly	2019-06-30	1601229000.0	+0.2%	USD	10-Q	2019-08-06
Quarterly	2019-09-30	1604168000.0	+0.2%	USD	10-Q	2019-11-05
Quarterly	2019-12-31	1607257000.0	+0.2%	USD	10-Q	2020-11-02
Quarterly	2020-03-31	1610371000.0	+0.2%	USD	10-Q	2020-05-05
Quarterly	2020-06-30	2103056000.0	+30.6%	USD	10-Q	2020-08-04
Quarterly	2020-09-30	2087684000.0	-0.7%	USD	10-Q	2020-11-02
Quarterly	2020-12-31	2094838000.0	+0.3%	USD	10-Q	2021-11-09
Quarterly	2021-03-31	2101646000.0	+0.3%	USD	10-Q	2021-05-04
Quarterly	2021-06-30	6737900000.0	+220.6%	USD	10-Q	2021-08-03
Quarterly	2021-09-30	6278287000.0	-6.8%	USD	10-Q	2021-11-09
Quarterly	2021-12-31	6049943000.0	-3.6%	USD	10-Q	2022-11-09
Quarterly	2022-03-31	6023868000.0	-0.4%	USD	10-Q	2022-05-04
Quarterly	2022-06-30	6020998000.0	-0.0%	USD	10-Q	2022-08-03
Quarterly	2022-09-30	5726814000.0	-4.9%	USD	10-Q	2022-11-09
Quarterly	2022-12-31	5724341000.0	-0.0%	USD	10-Q	2023-11-08
Quarterly	2023-03-31	5720662000.0	-0.1%	USD	10-Q	2023-05-10
Quarterly	2023-06-30	5717646000.0	-0.1%	USD	10-Q	2023-08-09
Quarterly	2023-09-30	5715264000.0	-0.0%	USD	10-Q	2023-11-08
Quarterly	2023-12-31	5712942000.0	-0.0%	USD	10-Q	2024-11-07
Quarterly	2024-03-31	5710486000.0	-0.0%	USD	10-Q	2024-05-02
Quarterly	2024-06-30	5706781000.0	-0.1%	USD	10-Q	2024-08-01
Quarterly	2024-09-30	6111802000.0	+7.1%	USD	10-Q	2024-11-07
Quarterly	2024-12-31	6108640000.0	-0.1%	USD	10-Q	2025-11-05
Quarterly	2025-03-31	5367481000.0	-12.1%	USD	10-Q	2025-05-07
Quarterly	2025-06-30	5364094000.0	-0.1%	USD	10-Q	2025-08-06
Quarterly	2025-09-30	5361161000.0	-0.1%	USD	10-Q	2025-11-05
Annual	2016-12-31	2029625000.0	—	USD	10-K	2018-02-27
Annual	2017-12-31	1581038000.0	-22.1%	USD	10-K	2019-02-26
Annual	2018-12-31	1596412000.0	+1.0%	USD	10-K	2020-02-25
Annual	2019-12-31	1607257000.0	+0.7%	USD	10-K	2021-02-23
Annual	2020-12-31	2094838000.0	+30.3%	USD	10-K	2022-03-01
Annual	2021-12-31	6049943000.0	+188.8%	USD	10-K	2023-03-01
Annual	2022-12-31	5724341000.0	-5.4%	USD	10-K	2024-02-28
Annual	2023-12-31	5712942000.0	-0.2%	USD	10-K	2025-02-26
Annual	2024-12-31	6108640000.0	+6.9%	USD	10-K	2026-02-24
Annual	2025-12-31	5358257000.0	-12.3%	USD	10-K	2026-02-24

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2019-03-31	7948000.0	—	USD	10-Q	2020-05-05
Quarterly	2019-06-30	21911000.0	+175.7%	USD	10-Q	2020-08-04
Quarterly	2019-09-30	32998000.0	+50.6%	USD	10-Q	2020-11-02
Quarterly	2020-03-31	4830000.0	-85.4%	USD	10-Q	2021-05-04
Quarterly	2020-06-30	7520000.0	+55.7%	USD	10-Q	2021-08-03
Quarterly	2020-09-30	10889000.0	+44.8%	USD	10-Q	2021-11-09
Quarterly	2021-03-31	2168000.0	-80.1%	USD	10-Q	2022-05-04
Quarterly	2021-06-30	9346000.0	+331.1%	USD	10-Q	2022-08-03
Quarterly	2021-09-30	17674000.0	+89.1%	USD	10-Q	2022-11-09
Quarterly	2022-03-31	12292000.0	-30.5%	USD	10-Q	2023-05-10
Quarterly	2022-06-30	24570000.0	+99.9%	USD	10-Q	2023-08-09
Quarterly	2022-09-30	19668000.0	-20.0%	USD	10-Q	2023-11-08
Quarterly	2023-03-31	3822000.0	-80.6%	USD	10-Q	2024-05-02
Quarterly	2023-06-30	9561000.0	+150.2%	USD	10-Q	2024-08-01
Quarterly	2023-09-30	13860000.0	+45.0%	USD	10-Q	2024-11-07
Quarterly	2024-03-31	6904000.0	-50.2%	USD	10-Q	2025-05-07
Quarterly	2024-06-30	13995000.0	+102.7%	USD	10-Q	2025-08-06
Quarterly	2024-09-30	24783000.0	+77.1%	USD	10-Q	2025-11-05
Quarterly	2025-03-31	13881000.0	-44.0%	USD	10-Q	2025-05-07
Quarterly	2025-06-30	26848000.0	+93.4%	USD	10-Q	2025-08-06
Quarterly	2025-09-30	42023000.0	+56.5%	USD	10-Q	2025-11-05
Annual	2018-12-31	20370000.0	—	USD	10-K	2021-02-23
Annual	2019-12-31	40135000.0	+97.0%	USD	10-K	2022-03-01
Annual	2020-12-31	15004000.0	-62.6%	USD	10-K	2023-03-01
Annual	2021-12-31	27641000.0	+84.2%	USD	10-K	2024-02-28
Annual	2022-12-31	29046000.0	+5.1%	USD	10-K	2025-02-26
Annual	2023-12-31	23962000.0	-17.5%	USD	10-K	2026-02-24
Annual	2024-12-31	38070000.0	+58.9%	USD	10-K	2026-02-24
Annual	2025-12-31	58752000.0	+54.3%	USD	10-K	2026-02-24

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	62616000.0	—	shares	10-Q	2017-05-09
Quarterly	2016-06-30	62043000.0	-0.9%	shares	10-Q	2017-08-08
Quarterly	2016-09-30	61795000.0	-0.4%	shares	10-Q	2017-11-07
Quarterly	2017-03-31	61178000.0	-1.0%	shares	10-Q	2018-05-08
Quarterly	2017-06-30	61463000.0	+0.5%	shares	10-Q	2018-08-07
Quarterly	2017-09-30	61436000.0	-0.0%	shares	10-Q	2018-11-06
Quarterly	2018-03-31	61178000.0	-0.4%	shares	10-Q	2019-05-07
Quarterly	2018-06-30	61438000.0	+0.4%	shares	10-Q	2019-08-06
Quarterly	2018-09-30	61857000.0	+0.7%	shares	10-Q	2019-11-05
Quarterly	2019-03-31	58081000.0	-6.1%	shares	10-Q	2020-05-05
Quarterly	2019-06-30	57427000.0	-1.1%	shares	10-Q	2020-08-04
Quarterly	2019-09-30	57438000.0	+0.0%	shares	10-Q	2020-11-02
Quarterly	2020-03-31	55956000.0	-2.6%	shares	10-Q	2021-05-04
Quarterly	2020-06-30	55864000.0	-0.2%	shares	10-Q	2021-08-03
Quarterly	2020-09-30	56236000.0	+0.7%	shares	10-Q	2021-11-09
Quarterly	2021-03-31	58393000.0	+3.8%	shares	10-Q	2022-05-04
Quarterly	2021-06-30	59448000.0	+1.8%	shares	10-Q	2022-08-03
Quarterly	2021-09-30	61284000.0	+3.1%	shares	10-Q	2022-11-09
Quarterly	2022-03-31	62907000.0	+2.6%	shares	10-Q	2023-05-10
Quarterly	2022-06-30	63431000.0	+0.8%	shares	10-Q	2023-08-09
Quarterly	2022-09-30	62785000.0	-1.0%	shares	10-Q	2023-11-08
Quarterly	2023-03-31	73771000.0	+17.5%	shares	10-Q	2024-05-02
Quarterly	2023-06-30	73540000.0	-0.3%	shares	10-Q	2024-08-01
Quarterly	2023-09-30	71293000.0	-3.1%	shares	10-Q	2024-11-07
Quarterly	2024-03-31	62537000.0	-12.3%	shares	10-Q	2025-05-07
Quarterly	2024-06-30	69625000.0	+11.3%	shares	10-Q	2025-08-06
Quarterly	2024-09-30	63174000.0	-9.3%	shares	10-Q	2025-11-05
Quarterly	2025-03-31	60979000.0	-3.5%	shares	10-Q	2025-05-07
Quarterly	2025-06-30	61194000.0	+0.4%	shares	10-Q	2025-08-06
Quarterly	2025-09-30	61606000.0	+0.7%	shares	10-Q	2025-11-05
Annual	2016-12-31	61870000.0	—	shares	10-K	2019-02-26
Annual	2017-12-31	61317000.0	-0.9%	shares	10-K	2020-02-25
Annual	2018-12-31	61221000.0	-0.2%	shares	10-K	2021-02-23
Annual	2019-12-31	57550000.0	-6.0%	shares	10-K	2022-03-01
Annual	2020-12-31	56517000.0	-1.8%	shares	10-K	2023-03-01
Annual	2021-12-31	59694000.0	+5.6%	shares	10-K	2024-02-28
Annual	2022-12-31	62539000.0	+4.8%	shares	10-K	2025-02-26
Annual	2023-12-31	72066000.0	+15.2%	shares	10-K	2026-02-24
Annual	2024-12-31	66007000.0	-8.4%	shares	10-K	2026-02-24
Annual	2025-12-31	60981000.0	-7.6%	shares	10-K	2026-02-24

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

5,358,257,000

Total Liabilities (latest annual)

N/A

Current Liabilities (latest annual)

2,242,521,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	0.0444	—	ratio	10-Q	2017-05-09
Quarterly	2016-06-30	0.0636	+43.3%	ratio	10-Q	2017-08-08
Quarterly	2016-09-30	0.0491	-22.8%	ratio	10-Q	2017-11-07
Quarterly	2017-03-31	0.0436	-11.1%	ratio	10-Q	2018-05-08
Quarterly	2017-06-30	0.0480	+10.0%	ratio	10-Q	2018-08-07
Quarterly	2017-09-30	0.0257	-46.4%	ratio	10-Q	2018-11-06
Quarterly	2018-03-31	0.0165	-35.8%	ratio	10-Q	2019-11-05
Quarterly	2018-06-30	0.0322	+94.9%	ratio	10-Q	2019-11-05
Quarterly	2018-09-30	0.0493	+53.3%	ratio	10-Q	2019-11-05
Quarterly	2019-03-31	0.0312	-36.7%	ratio	10-Q	2020-11-02
Quarterly	2019-06-30	0.0878	+181.3%	ratio	10-Q	2020-11-02
Quarterly	2019-09-30	0.0335	-61.9%	ratio	10-Q	2020-11-02
Quarterly	2020-03-31	-0.0562	-267.8%	ratio	10-Q	2021-11-09
Quarterly	2020-06-30	0.0365	+165.0%	ratio	10-Q	2021-11-09
Quarterly	2020-09-30	0.0439	+20.1%	ratio	10-Q	2021-11-09
Quarterly	2021-03-31	0.0321	-26.9%	ratio	10-Q	2022-11-09
Quarterly	2021-06-30	-0.0879	-374.1%	ratio	10-Q	2022-11-09
Quarterly	2021-09-30	-0.0134	+84.7%	ratio	10-Q	2022-11-09
Quarterly	2022-03-31	0.0005	+103.4%	ratio	10-Q	2023-11-08
Quarterly	2022-06-30	0.0108	+2272.8%	ratio	10-Q	2023-11-08
Quarterly	2022-09-30	-0.0072	-166.1%	ratio	10-Q	2023-11-08
Quarterly	2023-03-31	0.0208	+390.8%	ratio	10-Q	2024-11-07
Quarterly	2023-06-30	0.0296	+42.3%	ratio	10-Q	2024-11-07
Quarterly	2023-09-30	0.0421	+42.0%	ratio	10-Q	2024-11-07
Quarterly	2024-03-31	-0.0040	-109.4%	ratio	10-Q	2025-11-05
Quarterly	2024-06-30	0.0448	+1232.9%	ratio	10-Q	2025-11-05
Quarterly	2024-09-30	0.0516	+15.1%	ratio	10-Q	2025-11-05
Quarterly	2025-03-31	-0.0222	-143.0%	ratio	10-Q	2025-11-05
Quarterly	2025-06-30	-0.1938	-774.5%	ratio	10-Q	2025-11-05
Quarterly	2025-09-30	0.0635	+132.8%	ratio	10-Q	2025-11-05
Annual	2016-12-31	0.2114	—	ratio	10-K	2019-02-26
Annual	2017-12-31	0.1798	-14.9%	ratio	10-K	2020-02-25
Annual	2018-12-31	0.1621	-9.8%	ratio	10-K	2021-02-23
Annual	2019-12-31	0.1682	+3.8%	ratio	10-K	2022-03-01
Annual	2020-12-31	0.0652	-61.2%	ratio	10-K	2023-03-01
Annual	2021-12-31	-0.0831	-227.5%	ratio	10-K	2024-02-28
Annual	2022-12-31	-0.0726	+12.7%	ratio	10-K	2025-02-26
Annual	2023-12-31	0.1110	+252.9%	ratio	10-K	2026-02-24
Annual	2024-12-31	0.1368	+23.3%	ratio	10-K	2026-02-24
Annual	2025-12-31	-0.0825	-160.3%	ratio	10-K	2026-02-24

8-K Material Event Details

69 filings · 143 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

494 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-04-01	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	24	$191.74	$4,602	384,682
2026-04-01	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	2,292	$190.94	$437,631	384,706
2026-04-01	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	3,684	$190.22	$700,778	386,998
2026-03-05	COZADD BRUCE C	Dir	Other disposed transaction F	Ordinary Shares	15,114	$188.69	$2,851,861	390,682
2026-03-03	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	233	$187.84	$43,768	405,796
2026-03-03	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	2,608	$186.73	$487,002	406,029
2026-03-03	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	3,159	$186.09	$587,843	408,637
2026-02-27	RIEDEL NORBERT G	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,415	$0.00	$0	0
2026-02-27	RIEDEL NORBERT G	Dir	Open-market sell S	Ordinary Shares	3,415	$192.00	$655,680	7,024
2026-02-27	RIEDEL NORBERT G	Dir	Exercise / conversion M	Ordinary Shares	3,415	$138.08	$471,543	10,439
2026-02-26	Johnson Philip L	EVP & Chief Financial Officer	Equity grant / award A	Ordinary Shares	11,857	$0.00	$0	62,223
2026-01-16	Henderson Mary Elizabeth	SVP, Technical Operations	Equity grant / award A	Ordinary Shares	10,116	$0.00	$0	29,624
2025-12-09	Henderson Mary Elizabeth	SVP, Technical Operations	Open-market sell S	Ordinary Shares	2,238	$169.51	$379,366	19,508
2025-12-05	GALA RENEE D	President & CEO	Other disposed transaction F	Ordinary Shares	80	$166.91	$13,353	107,860
2025-12-02	O'Keefe Kenneth W	Dir	Other disposed transaction F	Ordinary Shares	603	$173.07	$104,361	25,811
2025-11-26	COZADD BRUCE C	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	76,689	$0.00	$0	0
2025-11-26	COZADD BRUCE C	Dir	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	811	$0.00	$0	0
2025-11-26	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	38,126	$177.27	$6,758,672	393,332
2025-11-26	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	507	$179.79	$91,155	431,458
2025-11-26	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	8,380	$179.23	$1,501,943	431,965
2025-11-26	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	30,487	$178.06	$5,428,567	440,345
2025-11-26	COZADD BRUCE C	Dir	Exercise / conversion M	Ordinary Shares	811	$123.36	$100,045	470,832
2025-11-26	COZADD BRUCE C	Dir	Exercise / conversion M	Ordinary Shares	76,689	$123.36	$9,460,355	470,021
2025-11-20	COZADD BRUCE C	Dir	Equity grant / award A	Ordinary Shares	2,506	$0.00	$0	393,332
2025-11-20	McSharry Heather Ann	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,415	$0.00	$0	0
2025-11-20	McSharry Heather Ann	Dir	Open-market sell S	Ordinary Shares	3,415	$177.78	$607,127	20,449
2025-11-20	McSharry Heather Ann	Dir	Exercise / conversion M	Ordinary Shares	3,415	$138.08	$471,543	23,864
2025-11-19	Henderson Mary Elizabeth	SVP, Technical Operations	Other disposed transaction D	Ordinary Shares	1,331	$180.40	$240,112	21,746
2025-11-18	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	717	$182.60	$130,925	390,826
2025-11-18	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	5,517	$181.81	$1,003,071	391,543
2025-11-18	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	8,382	$180.88	$1,516,131	397,060
2025-11-18	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	3,384	$180.09	$609,411	405,442
2025-11-17	Iannone Robert	EVP, Global Head of R&D & CMO	Open-market sell S	Ordinary Shares	7,159	$168.26	$1,204,573	72,628
2025-10-03	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	3,500	$140.00	$490,000	408,826
2025-10-01	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	2,000	$131.78	$263,560	412,326
2025-09-14	COZADD BRUCE C	Dir	Other disposed transaction F	Ordinary Shares	15,647	$126.16	$1,974,026	414,326
2025-09-02	COZADD BRUCE C	Dir	Open-market sell S	Ordinary Shares	3,000	$130.00	$390,000	429,973
2025-08-18	ENRIGHT PATRICK G	Dir	Other disposed transaction J	Ordinary Shares	5,000	$0.00	$0	21,379
2025-08-08	O'Keefe Kenneth W	Dir	Other disposed transaction F	Ordinary Shares	1,805	$111.25	$200,807	28,672
2025-08-07	O'Keefe Kenneth W	Dir	Equity grant / award A	Ordinary Shares	3,507	$0.00	$0	30,477
2025-08-05	Pearce Samantha	EVP, Chief Commercial Officer	Other disposed transaction F	Ordinary Shares	577	$116.10	$66,990	40,815
2025-08-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$113.21	$113,210	435,973
2025-07-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	500	$110.00	$55,000	436,973
2025-06-03	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	500	$110.00	$55,000	437,973
2025-06-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	500	$107.90	$53,950	438,473
2025-05-12	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	1,621	$103.00	$166,962	101,621
2025-05-09	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	100	$99.71	$9,971	100,000
2025-05-09	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	19,216	$98.91	$1,900,678	99,900
2025-05-09	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	80,684	$98.10	$7,915,472	80,684
2025-05-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	500	$120.00	$60,000	438,807
2025-05-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$116.35	$116,350	439,307
2025-04-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,500	$123.75	$185,625	440,307
2025-03-10	Iannone Robert	EVP, Global Head of R&D & CMO	Open-market sell S	Ordinary Shares	2,403	$138.41	$332,605	79,621
2025-03-07	Henderson Mary Elizabeth	SVP, Technical Operations	Other disposed transaction D	Ordinary Shares	698	$138.23	$96,485	23,077
2025-03-05	Pearce Samantha	EVP, Chief Commercial Officer	Other disposed transaction D	Ordinary Shares	1,905	$138.95	$264,700	41,226
2025-02-27	Iannone Robert	EVP, G R&D and CMO	Equity grant / award A	Ordinary Shares	8,859	$0.00	$0	94,343
2025-02-27	Iannone Robert	EVP, G R&D and CMO	Equity grant / award A	Ordinary Shares	17,718	$0.00	$0	85,484
2025-02-03	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,500	$122.31	$183,465	439,744
2025-01-17	Iannone Robert	EVP, G R&D and CMO	Other disposed transaction F	Ordinary Shares	2,181	$122.62	$267,434	67,766
2025-01-17	Iannone Robert	EVP, G R&D and CMO	Equity grant / award A	Ordinary Shares	7,506	$0.00	$0	69,947
2025-01-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,500	$123.43	$185,145	425,525
2024-12-05	GALA RENEE D	President & COO	Other disposed transaction F	Ordinary Shares	80	$123.45	$9,876	55,492
2024-12-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	2,000	$121.17	$242,340	427,025
2024-11-08	Patil Neena M	EVP & Chief Legal Officer	Open-market sell S	Ordinary Shares	3,700	$123.41	$456,617	33,048
2024-11-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$110.84	$110,840	428,976
2024-09-06	Henderson Mary Elizabeth	SVP, Technical Operations	Open-market sell S	Ordinary Shares	1,410	$108.30	$152,703	14,531
2024-08-02	ENRIGHT PATRICK G	Dir	Equity grant / award A	Ordinary Shares	3,731	$0.00	$0	24,677
2024-06-07	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	163	$108.83	$17,738	6,596
2024-05-03	Patil Neena M	EVP & Chief Legal Officer	Open-market sell S	Ordinary Shares	5,000	$109.65	$548,250	36,629
2024-04-05	GALA RENEE D	President & COO	Other disposed transaction F	Ordinary Shares	1,736	$115.21	$200,005	55,357
2024-03-07	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	1,768	$116.98	$206,821	6,596
2024-03-06	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	700	$117.51	$82,257	8,364
2024-03-06	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	1,236	$120.85	$149,371	9,064
2024-03-05	GALA RENEE D	President & COO	Other disposed transaction F	Ordinary Shares	3,622	$117.53	$425,694	57,093
2024-03-01	Henderson Mary Elizabeth	SVP, Technical Operations	Equity grant / award A	Ordinary Shares	5,178	$0.00	$0	15,941
2024-01-17	Pearce Samantha	SVP, Head of Europe & Internat	Other disposed transaction F	Ordinary Shares	1,038	$119.13	$123,657	14,331
2024-01-17	Pearce Samantha	SVP, Head of Europe & Internat	Equity grant / award A	Ordinary Shares	2,210	$0.00	$0	15,369
2023-12-04	Smith Mark Douglas	Dir	Open-market sell S	Ordinary Shares	417	$119.27	$49,736	6,888
2023-11-10	GALA RENEE D	President & COO	Equity grant / award A	Ordinary Shares	772	$0.00	$0	36,887
2023-09-01	Patil Neena M	EVP & Chief Legal Officer	Open-market sell S	Ordinary Shares	1,500	$144.25	$216,375	29,186
2023-08-29	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	142	$143.47	$20,373	5,986
2023-08-15	Patil Neena M	EVP & Chief Legal Officer	Open-market sell S	Ordinary Shares	750	$139.59	$104,695	30,686
2023-08-14	ORiordan Anne	Dir	Open-market sell S	Ordinary Shares	1,241	$138.16	$171,454	12,551
2023-08-14	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	158	$138.16	$21,829	6,128
2023-08-11	ORiordan Anne	Dir	Equity grant / award A	Ordinary Shares	3,075	$0.00	$0	13,792
2023-08-07	Patil Neena M	EVP & Chief Legal Officer	Other disposed transaction D	Ordinary Shares	1,390	$131.51	$182,799	31,436
2023-06-08	Mulligan Seamus	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	4,500	$0.00	$0	0
2023-06-08	Mulligan Seamus	Dir	Exercise / conversion M	Ordinary Shares	4,500	$81.76	$367,920	1,169,300
2023-06-07	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	126	$127.92	$16,117	6,286
2023-06-05	Iannone Robert	EVP, Global Head of Research a	Other disposed transaction D	Ordinary Shares	1,311	$129.73	$170,076	45,315
2023-06-01	Patil Neena M	EVP & Chief Legal Officer	Open-market sell S	Ordinary Shares	74	$128.01	$9,473	32,826
2023-06-01	Patil Neena M	EVP & Chief Legal Officer	Open-market sell S	Ordinary Shares	1,526	$127.98	$195,290	32,900
2023-05-18	GALA RENEE D	EVP & Chief Financial Officer	Open-market sell S	Ordinary Shares	6,000	$131.75	$790,474	35,978
2023-04-05	GALA RENEE D	EVP & Chief Financial Officer	Other disposed transaction F	Ordinary Shares	1,807	$145.78	$263,424	41,978
2023-03-15	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	1,023	$133.22	$136,284	6,286
2023-03-08	Sablich Kim	EVP, GM of U.S., Commercial Ma	Open-market sell S	Ordinary Shares	1,261	$140.19	$176,780	30,560
2023-03-08	Sablich Kim	EVP, GM of U.S., Commercial Ma	Open-market sell S	Ordinary Shares	1,752	$139.42	$244,264	31,821
2023-03-07	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	2,075	$140.76	$292,081	21,779
2023-03-07	O'Keefe Kenneth W	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	4,500	$0.00	$0	0
2023-03-07	O'Keefe Kenneth W	Dir	Open-market sell S	Ordinary Shares	2,690	$138.39	$372,267	22,889
2023-03-07	O'Keefe Kenneth W	Dir	Exercise / conversion M	Ordinary Shares	4,500	$81.76	$367,920	25,579
2023-03-06	Larkin Finbar	SVP, Technical Operations	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,706	$0.00	$0	0
2023-03-06	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	1,706	$143.92	$245,526	23,854
2023-03-06	Larkin Finbar	SVP, Technical Operations	Exercise / conversion M	Ordinary Shares	1,706	$58.72	$100,176	25,560
2023-03-04	Mulligan Seamus	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	4,500	$0.00	$0	0
2023-03-04	Mulligan Seamus	Dir	Exercise / conversion M	Ordinary Shares	4,500	$59.13	$266,085	1,164,800
2023-03-03	Larkin Finbar	SVP, Technical Operations	Equity grant / award A	Ordinary Shares	4,373	$0.00	$0	23,854
2023-02-02	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	531	$0.00	$0	6,907
2023-02-02	Pearce Samantha	SVP, Head of Europe & Internat	Open-market sell S	Ordinary Shares	531	$157.26	$83,505	11,309
2023-02-02	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M	Ordinary Shares	531	$109.45	$58,118	11,840
2023-02-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$155.79	$155,790	367,078
2023-01-03	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	531	$0.00	$0	7,438
2023-01-03	Pearce Samantha	SVP, Head of Europe & Internat	Open-market sell S	Ordinary Shares	531	$159.59	$84,742	11,309
2023-01-03	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M	Ordinary Shares	531	$109.45	$58,118	11,840
2022-12-21	GALA RENEE D	EVP & Chief Financial Officer	Open-market sell S	Ordinary Shares	2,635	$160.00	$421,600	32,558
2022-12-13	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	531	$0.00	$0	7,969
2022-12-13	Pearce Samantha	SVP, Head of Europe & Internat	Open-market sell S	Ordinary Shares	531	$155.45	$82,544	11,309
2022-12-13	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M	Ordinary Shares	531	$109.45	$58,118	11,840
2022-12-09	Iannone Robert	EVP, Global Head of R&D	Open-market sell S	Ordinary Shares	1,844	$151.54	$279,440	36,316
2022-12-05	Swisher Daniel N JR	President and COO	Other disposed transaction J	Ordinary Shares	10,465	$0.00	$0	46,984
2022-12-02	Cook Jennifer E.	Dir	Open-market sell S	Ordinary Shares	420	$154.68	$64,966	5,471
2022-12-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$157.00	$157,000	371,078
2022-11-22	ENRIGHT PATRICK G	Dir	Open-market sell S	Ordinary Shares	2,000	$152.88	$305,751	0
2022-11-22	ENRIGHT PATRICK G	Dir	Open-market sell S	Ordinary Shares	2,069	$149.90	$310,149	19,112
2022-11-22	ENRIGHT PATRICK G	Dir	Open-market sell S	Ordinary Shares	2,905	$149.18	$433,364	21,181
2022-11-16	Patil Neena M	EVP & Chief Legal Officer	Open-market sell S	Ordinary Shares	3,510	$142.34	$499,613	26,769
2022-11-14	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	197	$149.33	$29,418	19,409
2022-11-10	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	531	$0.00	$0	8,500
2022-11-10	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	532	$0.00	$0	9,031
2022-11-10	Pearce Samantha	SVP, Head of Europe & Internat	Open-market sell S	Ordinary Shares	531	$155.00	$82,305	11,309
2022-11-10	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M	Ordinary Shares	531	$109.45	$58,118	11,840
2022-11-10	Pearce Samantha	SVP, Head of Europe & Internat	Open-market sell S	Ordinary Shares	532	$155.00	$82,460	11,309
2022-11-10	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M	Ordinary Shares	532	$109.45	$58,227	11,841
2022-10-03	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	62,905	$0.00	$0	0
2022-10-03	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	7,748	$135.80	$1,052,213	374,028
2022-10-03	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	23,646	$135.18	$3,196,386	381,776
2022-10-03	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	13,791	$134.02	$1,848,307	405,422
2022-10-03	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	62,905	$59.13	$3,719,573	419,213
2022-09-07	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	63	$150.00	$9,450	19,606
2022-09-06	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,700	$0.00	$0	62,905
2022-09-06	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	542	$155.22	$84,129	356,308
2022-09-06	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	474	$154.31	$73,143	356,850
2022-09-06	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,170	$153.13	$179,162	357,324
2022-09-06	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	4,517	$152.41	$688,436	358,494
2022-09-06	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	9,700	$59.13	$573,561	363,011
2022-09-06	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$155.10	$155,100	353,311
2022-09-02	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	531	$0.00	$0	9,563
2022-09-02	Pearce Samantha	SVP, Head of Europe & Internat	Open-market sell S	Ordinary Shares	531	$156.98	$83,356	11,309
2022-09-02	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M	Ordinary Shares	531	$109.45	$58,118	11,840
2022-08-18	Gray Peter	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	8,000	$0.00	$0	0
2022-08-18	Gray Peter	Dir	Open-market sell S	Ordinary Shares	8,000	$158.00	$1,264,000	14,234
2022-08-18	Gray Peter	Dir	Exercise / conversion M	Ordinary Shares	8,000	$55.28	$442,240	22,234
2022-08-15	Carr Patricia	SVP, Chief Accounting Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	2,000	$0.00	$0	4,500
2022-08-15	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	2,000	$160.29	$320,580	5,934
2022-08-15	Carr Patricia	SVP, Chief Accounting Officer	Exercise / conversion M	Ordinary Shares	2,000	$113.10	$226,200	7,934
2022-08-15	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	142	$156.86	$22,274	5,934
2022-08-08	Winningham Rick E	Dir	Open-market sell S	Ordinary Shares	1,089	$152.32	$165,879	8,610
2022-08-08	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	158	$152.33	$24,067	6,076
2022-08-05	Winningham Rick E	Dir	Equity grant / award A	Ordinary Shares	2,561	$0.00	$0	9,699
2022-08-04	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	531	$0.00	$0	10,094
2022-08-04	Pearce Samantha	SVP, Head of Europe & Internat	Open-market sell S	Ordinary Shares	531	$155.00	$82,305	11,309
2022-08-04	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M	Ordinary Shares	531	$109.45	$58,118	11,840
2022-08-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	68	$0.00	$0	72,605
2022-08-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,632	$0.00	$0	0
2022-08-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$154.94	$154,940	354,311
2022-08-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,100	$155.27	$170,795	355,311
2022-08-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	2,601	$154.50	$401,858	356,411
2022-08-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	2,600	$153.48	$399,052	359,012
2022-08-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	68	$59.13	$4,021	361,612
2022-08-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	9,632	$46.83	$451,067	361,544
2022-07-12	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	532	$0.00	$0	10,625
2022-07-12	Pearce Samantha	SVP, Head of Europe & Internat	Open-market sell S	Ordinary Shares	532	$155.00	$82,460	11,309
2022-07-12	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M	Ordinary Shares	532	$109.45	$58,227	11,841
2022-07-05	Tovey Christopher J.	EVP, COO & Managing Director E	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	4,032	$0.00	$0	4,031
2022-07-05	Tovey Christopher J.	EVP, COO & Managing Director E	Open-market sell S	Ordinary Shares	1,177	$160.00	$188,320	14,663
2022-07-05	Tovey Christopher J.	EVP, COO & Managing Director E	Open-market sell S	Ordinary Shares	4,032	$160.00	$645,120	15,840
2022-07-05	Tovey Christopher J.	EVP, COO & Managing Director E	Exercise / conversion M	Ordinary Shares	4,032	$0.02	$81	19,872
2022-06-27	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	8,508	$0.00	$0	11,157
2022-06-27	Pearce Samantha	SVP, Head of Europe & Internat	Open-market sell S	Ordinary Shares	8,508	$155.00	$1,318,740	11,309
2022-06-27	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M	Ordinary Shares	8,508	$109.45	$931,201	19,817
2022-06-08	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	5,835	$0.00	$0	19,665
2022-06-08	Pearce Samantha	SVP, Head of Europe & Internat	Open-market sell S	Ordinary Shares	2,652	$155.00	$411,060	11,309
2022-06-08	Pearce Samantha	SVP, Head of Europe & Internat	Open-market sell S	Ordinary Shares	5,835	$155.00	$904,425	13,961
2022-06-08	Pearce Samantha	SVP, Head of Europe & Internat	Exercise / conversion M	Ordinary Shares	5,835	$109.45	$638,641	19,796
2022-06-06	Patil Neena M	Chief Legal Officer (CLO)	Open-market sell S	Ordinary Shares	1,000	$152.15	$152,150	31,600
2022-06-06	Iannone Robert	EVP, Global Head of R&D	Other disposed transaction F	Ordinary Shares	1,295	$149.25	$193,279	38,109
2022-06-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$150.00	$150,000	350,987
2022-06-02	Carr Patricia	SVP, Chief Accounting Officer	Open-market sell S	Ordinary Shares	131	$150.26	$19,684	6,234
2022-06-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,700	$0.00	$0	19,332
2022-06-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	489	$149.68	$73,194	351,987
2022-06-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	831	$148.82	$123,669	352,476
2022-06-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,270	$148.13	$188,125	353,307
2022-06-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,360	$146.05	$198,628	354,577
2022-06-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	2,412	$145.42	$350,753	355,937
2022-06-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	9,700	$46.83	$454,251	358,349
2022-05-10	Patil Neena M	Chief Legal Officer (CLO)	Equity grant / award G	Ordinary Shares	161	$0.00	$0	32,516
2022-05-09	ORiordan Anne	Dir	Open-market sell S	Ordinary Shares	9	$150.49	$1,354	9,245
2022-05-09	ORiordan Anne	Dir	Open-market sell S	Ordinary Shares	457	$148.92	$68,056	9,254
2022-05-06	Patil Neena M	Chief Legal Officer	Open-market sell S	Ordinary Shares	296	$153.92	$45,559	32,677
2022-05-05	Tovey Christopher J.	EVP, COO & Managing Director E	Other disposed transaction F	Ordinary Shares	1,096	$153.22	$167,929	15,840
2022-05-02	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,700	$0.00	$0	29,032
2022-05-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$158.67	$158,670	348,502
2022-05-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	716	$158.53	$113,507	349,502
2022-05-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	767	$156.97	$120,396	350,218
2022-05-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	3,177	$156.13	$496,025	350,985
2022-05-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,600	$155.34	$248,544	354,162
2022-05-02	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	9,700	$46.83	$454,251	355,762
2022-04-05	GALA RENEE D	EVP & CFO	Other disposed transaction F	Ordinary Shares	1,633	$162.88	$265,983	34,995
2022-04-04	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,700	$0.00	$0	38,732
2022-04-04	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	3,500	$160.00	$560,000	346,062
2022-04-04	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$158.64	$158,640	349,562
2022-04-04	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,294	$158.37	$204,934	350,562
2022-04-04	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	3,228	$157.49	$508,362	351,856
2022-04-04	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,750	$156.33	$273,569	355,084
2022-04-04	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	9,700	$46.83	$454,251	356,834
2022-03-17	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,288	$0.00	$0	0
2022-03-17	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	1,288	$59.13	$76,159	347,134
2022-03-03	Tovey Christopher J.	EVP & Chief Operating Officer	Equity grant / award A	Ordinary Shares	7,820	$0.00	$0	16,936
2022-03-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	6,000	$150.00	$900,000	322,987
2022-03-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,700	$0.00	$0	48,432
2022-03-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	200	$137.40	$27,481	328,987
2022-03-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	3,041	$136.73	$415,792	329,187
2022-03-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	3,260	$135.73	$442,486	332,228
2022-03-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	9,700	$46.83	$454,251	335,488
2022-02-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,700	$0.00	$0	58,132
2022-02-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	2,186	$140.26	$306,618	325,788
2022-02-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	2,136	$139.24	$297,416	327,974
2022-02-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	2,050	$138.11	$283,134	330,110
2022-02-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	9,700	$46.83	$454,251	332,160
2022-01-03	Swisher Daniel N JR	President and COO	Other disposed transaction F	Ordinary Shares	1,624	$131.01	$212,760	48,546
2021-12-02	Smith Mark Douglas	Dir	Open-market sell S	Ordinary Shares	417	$121.30	$50,582	4,419
2021-12-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,700	$0.00	$0	77,532
2021-12-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	2,758	$123.06	$339,413	318,551
2021-12-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	3,990	$122.38	$488,313	321,309
2021-12-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	9,700	$46.83	$454,251	325,299
2021-11-12	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	197	$135.79	$26,751	16,468
2021-11-11	Sablich Kim	EVP & GM, North America	Open-market sell S	Ordinary Shares	2,748	$135.01	$371,000	21,135
2021-11-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,700	$0.00	$0	87,232
2021-11-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	2,729	$135.45	$369,634	315,536
2021-11-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,934	$134.78	$260,670	318,265
2021-11-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,893	$133.70	$253,087	320,199
2021-11-01	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	9,700	$46.83	$454,251	322,092
2021-10-04	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	9,700	$0.00	$0	96,932
2021-10-04	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	6,598	$129.87	$856,903	312,392
2021-10-04	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	9,700	$46.83	$454,251	318,990
2021-09-08	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	63	$134.51	$8,474	16,579
2021-09-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	500	$131.58	$65,790	309,290
2021-08-18	ENRIGHT PATRICK G	Dir	Equity grant / award A	Ordinary Shares	2,000	$137.75	$275,500	2,000
2021-08-06	Winningham Rick E	Dir	Open-market sell S	Ordinary Shares	1,306	$147.96	$193,236	7,138
2021-08-05	Schnee Elmar	Dir	Open-market sell S	Ordinary Shares	1,632	$154.00	$251,328	8,270
2021-08-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	250	$170.00	$42,500	307,138
2021-08-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,500	$169.98	$254,970	307,388
2021-07-29	Winningham Rick E	Dir	Equity grant / award A	Ordinary Shares	2,246	$0.00	$0	8,444
2021-07-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	10,850	$180.67	$1,960,270	308,888
2021-06-05	Iannone Robert	EVP R&D, Chief Medical Officer	Other disposed transaction F	Ordinary Shares	1,206	$176.47	$212,823	29,086
2021-06-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,750	$179.07	$313,372	319,738
2021-05-05	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	500	$170.00	$85,000	321,341
2021-05-05	Tovey Christopher J.	EVP COO & Managing Dir EUR/INT	Equity grant / award A	Ordinary Shares	9,091	$0.00	$0	9,116
2021-05-03	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,500	$164.24	$246,360	321,841
2021-04-05	GALA RENEE D	EVP & CFO	Other disposed transaction F	Ordinary Shares	1,515	$164.71	$249,536	25,347
2021-04-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,500	$164.96	$247,440	323,341
2021-03-08	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	1,509	$161.60	$243,859	16,519
2021-03-05	Swisher Daniel N JR	President and COO	Other disposed transaction F	Ordinary Shares	3,718	$164.75	$612,540	49,961
2021-03-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	9,600	$170.00	$1,632,000	346,357
2021-02-25	Swisher Daniel N JR	President and COO	Equity grant / award A	Ordinary Shares	11,695	$0.00	$0	53,679
2021-02-03	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	250	$160.00	$40,000	318,032
2021-02-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,250	$156.15	$195,188	318,282
2021-01-04	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	7,950	$162.01	$1,287,980	319,532
2020-12-04	Carr Patricia	VP, Finance & PAO	Open-market sell S	Ordinary Shares	62	$152.55	$9,458	6,200
2020-12-03	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	250	$150.00	$37,500	327,482
2020-12-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$140.58	$140,580	327,732
2020-11-12	ENRIGHT PATRICK G	Dir	Open-market sell S	Ordinary Shares	1,623	$147.61	$239,575	20,368
2020-11-12	ENRIGHT PATRICK G	Dir	Open-market sell S	Ordinary Shares	5,083	$147.00	$747,217	21,991
2020-11-12	ENRIGHT PATRICK G	Dir	Open-market sell S	Ordinary Shares	3,223	$145.81	$469,946	27,074
2020-11-06	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	197	$151.93	$29,930	13,964
2020-11-05	O'Keefe Kenneth W	Dir	Open-market sell S	Ordinary Shares	4,513	$156.44	$706,003	18,667
2020-11-05	O'Keefe Kenneth W	Dir	Open-market sell S	Ordinary Shares	1,746	$155.14	$270,867	23,180
2020-11-05	O'Keefe Kenneth W	Dir	Open-market sell S	Ordinary Shares	2,740	$153.74	$421,255	24,926
2020-11-05	O'Keefe Kenneth W	Dir	Open-market sell S	Ordinary Shares	2,001	$152.57	$305,295	27,666
2020-11-04	Sohn Catherine A.	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	4,500	$0.00	$0	0
2020-11-04	Sohn Catherine A.	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	8,000	$0.00	$0	0
2020-11-04	Sohn Catherine A.	Dir	Open-market sell S	Ordinary Shares	8,000	$152.00	$1,216,000	10,622
2020-11-04	Sohn Catherine A.	Dir	Exercise / conversion M	Ordinary Shares	8,000	$46.83	$374,640	18,622
2020-11-04	Sohn Catherine A.	Dir	Open-market sell S	Ordinary Shares	4,500	$156.00	$702,000	10,622
2020-11-04	Sohn Catherine A.	Dir	Exercise / conversion M	Ordinary Shares	4,500	$81.76	$367,920	15,122
2020-11-04	BERNS PAUL L	Dir	Open-market sell S	Ordinary Shares	3,825	$150.90	$577,186	9,740
2020-11-04	BERNS PAUL L	Dir	Open-market sell S	Ordinary Shares	400	$149.28	$59,711	13,565
2020-11-04	BERNS PAUL L	Dir	Open-market sell S	Ordinary Shares	466	$147.44	$68,707	13,965
2020-11-02	BERNS PAUL L	Dir	Exercise / conversion M · derivative	Phantom Stock	4,691	—	—	0
2020-11-02	BERNS PAUL L	Dir	Exercise / conversion M	Ordinary Shares	4,691	—	—	14,431
2020-10-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	4,500	$141.94	$638,730	332,180
2020-09-09	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	63	$138.53	$8,727	14,161
2020-09-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	500	$134.90	$67,450	336,680
2020-08-27	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	3,000	$130.00	$390,000	337,180
2020-08-12	Carr Patricia	VP, Finance & PAO	Open-market sell S	Ordinary Shares	142	$123.80	$17,580	6,200
2020-08-07	Carr Patricia	VP, Finance & PAO	Open-market sell S	Ordinary Shares	158	$125.87	$19,887	6,342
2020-08-06	ORiordan Anne	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	6,765	$0.00	$0	6,765
2020-08-06	ORiordan Anne	Dir	Equity grant / award A	Ordinary Shares	2,705	$0.00	$0	7,465
2020-08-05	Patil Neena M	SVP, General Counsel	Other disposed transaction F	Ordinary Shares	987	$122.24	$120,651	19,489
2020-06-05	Iannone Robert	EVP, Research & Development	Other disposed transaction F	Ordinary Shares	943	$120.65	$113,773	22,204
2020-05-27	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	11,482	$112.32	$1,289,646	1,152,788
2020-05-27	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	9,884	$111.56	$1,102,682	1,141,306
2020-05-27	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	8,391	$110.52	$927,352	1,131,422
2020-05-27	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	5,243	$109.55	$574,379	1,123,031
2020-05-26	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	15,000	$110.65	$1,659,747	1,117,788
2020-05-07	GALA RENEE D	EVP & CFO	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	37,848	$0.00	$0	37,848
2020-05-07	GALA RENEE D	EVP & CFO	Equity grant / award A · derivative	Incentive Stock Option (right to buy)	3,652	$0.00	$0	3,652
2020-05-07	GALA RENEE D	EVP & CFO	Equity grant / award A	Ordinary Shares	16,600	$0.00	$0	16,600
2020-03-12	Carr Patricia	VP, Finance & PAO	Open-market sell S	Ordinary Shares	600	$102.17	$61,302	6,500
2020-03-09	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	615	$111.49	$68,566	13,883
2020-03-06	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	292	$119.15	$34,793	14,498
2020-03-05	Swisher Daniel N JR	President and COO	Other disposed transaction F	Ordinary Shares	1,735	$124.50	$216,008	43,391
2020-03-03	Larkin Finbar	SVP, Technical Operations	Open-market sell S	Ordinary Shares	279	$119.75	$33,410	14,790
2020-02-27	Swisher Daniel N JR	President and COO	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	39,114	$0.00	$0	39,114
2020-02-27	Swisher Daniel N JR	President and COO	Equity grant / award A · derivative	Incentive Stock Option (right to buy)	886	$0.00	$0	886
2020-02-27	Swisher Daniel N JR	President and COO	Equity grant / award A	Ordinary Shares	16,000	$0.00	$0	45,126
2020-02-25	COZADD BRUCE C	Chairman & CEO	Other disposed transaction F	Ordinary Shares	2,679	$127.25	$340,903	303,104
2020-02-25	MILLER MICHAEL PATRICK	EVP, US Commercial	Other disposed transaction F	Ordinary Shares	530	$127.25	$67,442	26,041
2020-02-24	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	6,895	$0.00	$0	0
2020-02-24	COZADD BRUCE C	Chairman & CEO	Exercise / conversion M	Ordinary Shares	6,895	$11.48	$79,155	305,783
2020-02-13	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	1,500	$142.18	$213,270	26,571
2020-02-03	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$143.83	$143,830	298,888
2020-01-13	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	1,500	$146.78	$220,170	28,071
2020-01-03	Swisher Daniel N JR	President and COO	Other disposed transaction D	Ordinary Shares	1,599	$146.09	$233,598	29,126
2020-01-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	250	$150.00	$37,500	299,888
2020-01-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$149.51	$149,510	300,138
2019-12-09	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	1,500	$149.12	$223,680	29,571
2019-12-05	Carr Patricia	VP, Finance & PAO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	1,667	$0.00	$0	313
2019-12-05	Carr Patricia	VP, Finance & PAO	Open-market sell S	Ordinary Shares	82	$149.84	$12,287	5,800
2019-12-05	Carr Patricia	VP, Finance & PAO	Open-market sell S	Ordinary Shares	1,667	$148.89	$248,198	5,882
2019-12-05	Carr Patricia	VP, Finance & PAO	Exercise / conversion M	Ordinary Shares	1,667	$123.36	$205,641	7,549
2019-12-04	O'Keefe Kenneth W	Dir	Open-market sell S	Ordinary Shares	6,750	$147.82	$997,774	4,445
2019-12-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	10,750	$150.00	$1,612,500	301,138
2019-11-07	Larkin Finbar	SVP, Technical Operations	Equity grant / award A	Ordinary Shares	1,500	$0.00	$0	9,988
2019-11-05	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	500	$130.00	$65,000	311,855
2019-10-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	500	$130.00	$65,000	312,355
2019-08-12	Treacy Paul	SVP, Technical Operations	Open-market sell S	Ordinary Shares	4,371	$137.40	$600,589	16,418
2019-08-08	Carr Patricia	VP, Finance& PAO	Equity grant / award A	Ordinary Shares	1,200	$0.00	$0	5,800
2019-06-05	MILLER MICHAEL PATRICK	EVP, US Commercial	Other disposed transaction F	Ordinary Shares	123	$130.40	$16,039	31,039
2019-03-06	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	1,152	$135.41	$155,992	36,200
2019-03-06	Treacy Paul	SVP, Technical Operations	Open-market sell S	Ordinary Shares	589	$135.41	$79,756	20,649
2019-03-06	Treacy Paul	SVP, Technical Operations	Open-market sell S	Ordinary Shares	471	$135.41	$63,778	21,238
2019-03-05	Young Matthew P.	EVP & CFO	Other disposed transaction F	Ordinary Shares	1,348	$135.82	$183,085	37,352
2019-03-05	Young Matthew P.	EVP & CFO	Other disposed transaction F	Ordinary Shares	1,267	$135.82	$172,084	38,700
2019-02-28	ORiordan Anne	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	7,100	$0.00	$0	7,100
2019-02-28	ORiordan Anne	Dir	Equity grant / award A	Ordinary Shares	2,840	$0.00	$0	2,840
2019-02-27	Hooper Suzanne Sawochka	EVP & General Counsel	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	6,666	$0.00	$0	28,671
2019-02-27	Hooper Suzanne Sawochka	EVP & General Counsel	Open-market sell S	Ordinary Shares	6,666	$140.00	$933,240	39,738
2019-02-27	Hooper Suzanne Sawochka	EVP & General Counsel	Exercise / conversion M	Ordinary Shares	6,666	$46.83	$312,169	46,404
2019-02-26	Hooper Suzanne Sawochka	EVP & General Counsel	Other disposed transaction F	Ordinary Shares	663	$127.76	$84,705	39,738
2019-02-25	Hooper Suzanne Sawochka	EVP & General Counsel	Other disposed transaction F	Ordinary Shares	783	$126.25	$98,854	40,401
2019-01-03	Swisher Daniel N JR	President and COO	Other disposed transaction F	Ordinary Shares	1,604	$126.01	$202,120	16,512
2018-12-14	Hooper Suzanne Sawochka	EVP & General Counsel	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,295	$0.00	$0	35,337
2018-12-14	Hooper Suzanne Sawochka	EVP & General Counsel	Open-market sell S	Ordinary Shares	39	$140.21	$5,468	41,184
2018-12-14	Hooper Suzanne Sawochka	EVP & General Counsel	Open-market sell S	Ordinary Shares	3,295	$140.21	$461,992	41,223
2018-12-14	Hooper Suzanne Sawochka	EVP & General Counsel	Exercise / conversion M	Ordinary Shares	3,295	$46.83	$154,305	44,518
2018-12-03	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$151.78	$151,780	277,688
2018-11-23	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	700	$150.00	$105,000	32,068
2018-11-15	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	22,137	$145.05	$3,210,892	1,100,868
2018-11-15	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	26,363	$144.24	$3,802,681	1,078,731
2018-11-15	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	1,200	$143.22	$171,869	1,052,368
2018-11-15	Mulligan Seamus	Dir	Open-market buy P	Ordinary Shares	300	$141.86	$42,559	1,051,168
2018-11-13	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$149.27	$29,854	24,972
2018-11-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,300	$159.45	$207,290	278,615
2018-10-15	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	700	$158.08	$110,658	32,768
2018-10-12	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$158.46	$31,692	25,172
2018-10-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,300	$167.99	$218,387	279,915
2018-09-21	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,300	$164.36	$213,668	281,215
2018-09-17	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	700	$162.70	$113,890	33,468
2018-09-14	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$165.20	$33,040	25,372
2018-09-06	ENRIGHT PATRICK G	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,415	$0.00	$0	0
2018-09-06	ENRIGHT PATRICK G	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	3,300	$0.00	$0	0
2018-09-06	ENRIGHT PATRICK G	Dir	Open-market sell S	Ordinary Shares	1,000	$169.69	$169,694	16,469
2018-09-06	ENRIGHT PATRICK G	Dir	Open-market sell S	Ordinary Shares	7,086	$168.86	$1,196,565	17,469
2018-09-06	ENRIGHT PATRICK G	Dir	Open-market sell S	Ordinary Shares	2,044	$167.96	$343,305	24,555
2018-09-06	ENRIGHT PATRICK G	Dir	Exercise / conversion M	Ordinary Shares	3,300	$135.44	$446,952	26,599
2018-09-06	ENRIGHT PATRICK G	Dir	Exercise / conversion M	Ordinary Shares	3,415	$138.08	$471,543	23,299
2018-08-15	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	700	$176.05	$123,235	34,168
2018-08-14	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$175.70	$35,140	25,572
2018-08-10	RIEDEL NORBERT G	Dir	Open-market sell S	Ordinary Shares	660	$176.61	$116,563	6,491
2018-08-10	Treacy Paul	SVP, Technical Operations	Open-market sell S	Ordinary Shares	1,309	$176.61	$231,183	17,458
2018-08-09	RIEDEL NORBERT G	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	3,735	$0.00	$0	3,735
2018-08-09	RIEDEL NORBERT G	Dir	Equity grant / award A	Ordinary Shares	1,495	$0.00	$0	7,151
2018-08-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,600	$173.90	$278,240	282,515
2018-07-16	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	700	$176.06	$123,242	34,868
2018-07-13	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$179.15	$35,830	25,772
2018-07-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,600	$170.81	$273,296	284,115
2018-06-15	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	700	$176.99	$123,893	35,568
2018-06-14	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$176.53	$35,306	25,972
2018-06-05	MILLER MICHAEL PATRICK	EVP, US Commercial	Other disposed transaction F	Ordinary Shares	123	$172.54	$21,222	26,172
2018-06-01	Young Matthew P.	EVP & CFO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	5,000	$0.00	$0	12,192
2018-06-01	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	5,000	$170.04	$850,212	36,268
2018-06-01	Young Matthew P.	EVP & CFO	Exercise / conversion M	Ordinary Shares	5,000	$58.72	$293,600	41,268
2018-05-15	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	1,420	$164.64	$233,789	36,203
2018-05-14	Young Matthew P.	EVP & CFO	Other disposed transaction F	Ordinary Shares	842	$166.00	$139,772	37,623
2018-05-11	WILSON KAREN J	SVP, Finance & PAO	Open-market sell S	Ordinary Shares	54	$165.00	$8,910	15,757
2018-05-11	WILSON KAREN J	SVP, Finance & PAO	Open-market sell S	Ordinary Shares	3,706	$165.00	$611,490	15,811
2018-05-07	MILLER MICHAEL PATRICK	EVP, US Commercial	Other disposed transaction F	Ordinary Shares	1,159	$147.03	$170,408	26,322
2018-05-01	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$151.57	$151,570	292,542
2018-04-16	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	700	$156.01	$109,207	38,465
2018-04-13	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$157.49	$31,498	27,481
2018-04-10	WILSON KAREN J	SVP, Finance & PAO	Open-market sell S	Ordinary Shares	3,899	$155.00	$604,345	19,517
2018-04-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$150.01	$150,010	293,542
2018-03-15	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	700	$151.22	$105,854	39,165
2018-03-14	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$151.12	$30,224	27,681
2018-03-09	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$150.00	$150,000	294,542
2018-03-06	Treacy Paul	SVP, Technical Operations	Open-market sell S	Ordinary Shares	594	$141.47	$84,030	18,641
2018-03-05	COZADD BRUCE C	Chairman & CEO	Other disposed transaction F	Ordinary Shares	4,288	$143.39	$614,856	295,542
2018-03-01	Young Matthew P.	EVP & CFO	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	22,790	$0.00	$0	22,790
2018-03-01	Young Matthew P.	EVP & CFO	Equity grant / award A · derivative	Incentive Stock Option (right to buy)	710	$0.00	$0	710
2018-03-01	Young Matthew P.	EVP & CFO	Equity grant / award A	Ordinary Shares	9,400	$0.00	$0	42,365
2018-02-28	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	700	$150.00	$105,000	32,965
2018-02-28	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	119	$147.56	$17,559	33,865
2018-02-28	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	200	$149.01	$29,803	33,665
2018-02-27	Young Matthew P.	EVP & CFO	Other disposed transaction F	Ordinary Shares	606	$143.80	$87,143	34,184
2018-02-27	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	300	$147.30	$44,189	34,790
2018-02-27	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	600	$145.83	$87,500	35,090
2018-02-27	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	1,016	$144.96	$147,280	35,690
2018-02-26	Young Matthew P.	EVP & CFO	Other disposed transaction F	Ordinary Shares	2,253	$147.44	$332,182	36,706
2018-02-14	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$139.99	$27,998	21,469
2018-01-16	Young Matthew P.	EVP & CFO	Open-market sell S	Ordinary Shares	700	$152.16	$106,512	38,959
2018-01-12	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$148.65	$29,730	21,669
2017-12-11	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$139.15	$27,830	21,869
2017-11-17	McGill Iain	SVP, Europe & Rest of World	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	8,000	$133.42	$1,067,358	4,500
2017-11-17	McGill Iain	SVP, Europe & Rest of World	Open-market sell S	Ordinary Shares	8,000	$133.42	$1,067,358	20,383
2017-11-17	McGill Iain	SVP, Europe & Rest of World	Exercise / conversion M	Ordinary Shares	8,000	$46.83	$374,640	28,383
2017-10-02	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$150.00	$150,000	276,664
2017-09-12	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$153.52	$153,520	277,664
2017-08-25	ENRIGHT PATRICK G	Dir	Open-market sell S	Ordinary Shares	351	$148.40	$52,088	1,717
2017-08-15	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$144.38	$28,876	21,996
2017-08-14	Treacy Paul	SVP, Technical Operations	Open-market sell S	Ordinary Shares	1,104	$143.30	$158,203	16,385
2017-08-14	Treacy Paul	SVP, Technical Operations	Open-market sell S	Ordinary Shares	200	$143.41	$28,681	17,489
2017-08-11	Winningham Rick E	Dir	Open-market sell S	Ordinary Shares	3	$144.22	$433	11,094
2017-08-11	Winningham Rick E	Dir	Open-market sell S	Ordinary Shares	659	$142.36	$93,815	11,097
2017-08-10	Winningham Rick E	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	3,415	$0.00	$0	3,415
2017-08-10	Winningham Rick E	Dir	Equity grant / award A	Ordinary Shares	1,365	$0.00	$0	11,756
2017-08-07	Cox Russell J.	EVP & COO	Other disposed transaction F	Ordinary Shares	978	$155.56	$152,138	51,985
2017-07-20	Hooper Suzanne Sawochka	EVP & General Counsel	Open-market sell S	Ordinary Shares	4,580	$160.00	$732,800	32,322
2017-07-17	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$154.97	$30,994	22,196
2017-06-23	Hooper Suzanne Sawochka	EVP & General Counsel	Open-market sell S	Ordinary Shares	420	$160.00	$67,200	36,902
2017-06-15	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$150.65	$30,130	22,223
2017-06-01	Winningham Rick E	Dir	Open-market sell S	Ordinary Shares	5,000	$150.00	$750,000	10,391
2017-05-15	MILLER MICHAEL PATRICK	EVP, US Commercial	Open-market sell S	Ordinary Shares	200	$152.98	$30,596	22,423
2017-05-12	Young Matthew P.	EVP & CFO	Other disposed transaction F	Ordinary Shares	815	$153.79	$125,339	39,533
2017-05-11	MILLER MICHAEL PATRICK	EVP, US Commercial	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	2,500	$0.00	$0	2,500
2017-05-11	MILLER MICHAEL PATRICK	EVP, US Commercial	Equity grant / award A	Ordinary Shares	1,000	$0.00	$0	22,623
2017-05-09	Hooper Suzanne Sawochka	EVP & General Counsel	Open-market sell S	Ordinary Shares	2,500	$160.00	$400,000	37,149
2017-05-05	MILLER MICHAEL PATRICK	EVP, US Commercial	Other disposed transaction F	Ordinary Shares	939	$159.06	$149,357	21,623
2017-05-03	Young Matthew P.	EVP & CFO	Other disposed transaction F	Ordinary Shares	1,565	$158.38	$247,865	40,348
2017-04-27	Hooper Suzanne Sawochka	EVP & General Counsel	Open-market sell S	Ordinary Shares	2,500	$160.00	$400,000	39,649
2017-04-17	MILLER MICHAEL PATRICK	SVP, US Commercial	Open-market sell S	Ordinary Shares	200	$152.56	$30,512	22,562
2017-04-11	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$152.12	$152,120	308,491
2017-04-10	WILSON KAREN J	SVP, Finance & PAO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	4,750	$0.00	$0	0
2017-04-10	WILSON KAREN J	SVP, Finance & PAO	Exercise / conversion M · derivative	Non-Qualified Stock Option (right to buy)	6,708	$0.00	$0	0
2017-04-10	WILSON KAREN J	SVP, Finance & PAO	Open-market sell S	Ordinary Shares	6,708	$152.24	$1,021,226	22,408
2017-04-10	WILSON KAREN J	SVP, Finance & PAO	Exercise / conversion M	Ordinary Shares	6,708	$46.83	$314,136	29,116
2017-04-10	WILSON KAREN J	SVP, Finance & PAO	Open-market sell S	Ordinary Shares	4,750	$152.24	$723,140	22,408
2017-04-10	WILSON KAREN J	SVP, Finance & PAO	Exercise / conversion M	Ordinary Shares	4,750	$59.13	$280,868	27,158
2017-03-15	MILLER MICHAEL PATRICK	SVP, US Commercial	Open-market sell S	Ordinary Shares	200	$137.89	$27,578	22,762
2017-03-06	Hooper Suzanne Sawochka	EVP & General Counsel	Other disposed transaction F	Ordinary Shares	2,087	$132.81	$277,174	42,149
2017-03-02	Hooper Suzanne Sawochka	EVP & General Counsel	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	24,266	$0.00	$0	24,266
2017-03-02	Hooper Suzanne Sawochka	EVP & General Counsel	Equity grant / award A · derivative	Incentive Stock Option (right to buy)	734	$0.00	$0	734
2017-03-02	Hooper Suzanne Sawochka	EVP & General Counsel	Equity grant / award A	Ordinary Shares	10,000	$0.00	$0	44,236
2017-02-27	Young Matthew P.	EVP & CFO	Other disposed transaction F	Ordinary Shares	1,994	$136.97	$273,118	31,913
2017-02-15	MILLER MICHAEL PATRICK	SVP, US Commercial	Open-market sell S	Ordinary Shares	200	$134.55	$26,910	16,486
2017-01-18	Cox Russell J.	EVP & COO	Open-market sell S	Ordinary Shares	3,000	$130.00	$390,000	47,095
2017-01-18	Cox Russell J.	EVP & COO	Open-market sell S	Ordinary Shares	1,000	$125.00	$125,000	50,095
2017-01-17	MILLER MICHAEL PATRICK	SVP, US Commercial	Open-market sell S	Ordinary Shares	200	$115.93	$23,186	16,686
2016-12-15	MILLER MICHAEL PATRICK	SVP, US Commercial	Open-market sell S	Ordinary Shares	200	$103.09	$20,618	16,886
2016-12-02	ENRIGHT PATRICK G	Dir	Open-market sell S	Ordinary Shares	677	$101.80	$68,919	1,365
2016-11-15	MILLER MICHAEL PATRICK	SVP, US Commercial	Open-market sell S	Ordinary Shares	200	$112.19	$22,438	16,925
2016-11-14	O'Keefe Kenneth W	Dir	Open-market buy P	Ordinary Shares	500	$112.45	$56,224	2,000
2016-11-11	O'Keefe Kenneth W	Dir	Open-market buy P	Ordinary Shares	300	$114.33	$34,299	1,500
2016-11-11	O'Keefe Kenneth W	Dir	Open-market buy P	Ordinary Shares	1,200	$114.30	$137,166	1,200
2016-10-17	MILLER MICHAEL PATRICK	SVP, US Commercial	Open-market sell S	Ordinary Shares	200	$118.16	$23,632	17,125
2016-09-19	MILLER MICHAEL PATRICK	SVP, US Commercial	Open-market sell S	Ordinary Shares	200	$126.17	$25,234	17,325
2016-08-25	Mulligan Seamus	Dir	Open-market sell S	Ordinary Shares	4,620	$129.42	$597,908	1,048,008
2016-08-25	Mulligan Seamus	Dir	Open-market sell S	Ordinary Shares	10,283	$128.97	$1,326,191	1,052,628
2016-08-25	Mulligan Seamus	Dir	Open-market sell S	Ordinary Shares	9,500	$127.70	$1,213,177	1,062,911
2016-08-25	Mulligan Seamus	Dir	Open-market sell S	Ordinary Shares	3,565	$126.65	$451,511	1,072,411
2016-08-16	Treacy Paul	SVP, Technical Operations	Open-market sell S	Ordinary Shares	5	$137.46	$687	13,870
2016-08-16	Treacy Paul	SVP, Technical Operations	Open-market sell S	Ordinary Shares	1,287	$137.47	$176,921	13,875
2016-08-15	Winningham Rick E	Dir	Open-market sell S	Ordinary Shares	633	$136.45	$86,373	15,391
2016-08-12	Smith Karen L.	Global Head of R&D and CMO	Open-market buy P	Ordinary Shares	1	$137.26	$137	14,182
2016-08-12	Smith Karen L.	Global Head of R&D and CMO	Open-market buy P	Ordinary Shares	607	$137.10	$83,218	14,181
2016-08-11	Winningham Rick E	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	3,415	$0.00	$0	3,415
2016-08-11	Winningham Rick E	Dir	Equity grant / award A	Ordinary Shares	1,365	$0.00	$0	16,024
2016-08-09	Cox Russell J.	EVP & COO	Open-market sell S	Ordinary Shares	4,000	$148.66	$594,640	51,038
2016-08-09	Cox Russell J.	EVP & COO	Other disposed transaction F	Ordinary Shares	4,565	$150.01	$684,796	55,038
2016-08-09	COZADD BRUCE C	Chairman & CEO	Other disposed transaction F	Ordinary Shares	9,071	$150.01	$1,360,741	290,113
2016-08-09	COZADD BRUCE C	Chairman & CEO	Open-market sell S	Ordinary Shares	1,000	$150.00	$150,000	299,184
2016-08-07	Cox Russell J.	EVP & COO	Other disposed transaction F	Ordinary Shares	978	$149.02	$145,742	59,603
2016-07-15	MILLER MICHAEL PATRICK	SVP, US Commercial	Open-market sell S	Ordinary Shares	100	$142.43	$14,243	17,625
2016-07-13	Smith Karen L.	Global Head of R&D and CMO	Open-market buy P	Ordinary Shares	580	$143.63	$83,305	13,574

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count