Financial Metrics

NBIX NEUROCRINE BIOSCIENCES INC

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2017-09-30	-0.13	—	USD/shares	10-Q	2018-11-05
Quarterly	2018-06-30	-0.07	+46.2%	USD/shares	10-Q	2019-07-29
Quarterly	2018-09-30	0.52	+842.9%	USD/shares	10-Q	2019-11-04
Quarterly	2019-03-31	-1.12	-315.4%	USD/shares	10-Q	2020-05-06
Quarterly	2019-06-30	0.54	+148.2%	USD/shares	10-Q	2020-08-03
Quarterly	2019-09-30	0.56	+3.7%	USD/shares	10-Q	2020-11-09
Quarterly	2020-03-31	0.39	-30.4%	USD/shares	10-Q	2021-05-05
Quarterly	2020-06-30	0.81	+107.7%	USD/shares	10-Q	2021-08-03
Quarterly	2020-09-30	-0.62	-176.5%	USD/shares	10-Q	2021-11-01
Quarterly	2021-03-31	0.33	+153.2%	USD/shares	10-Q	2022-05-04
Quarterly	2021-06-30	0.43	+30.3%	USD/shares	10-Q	2022-08-04
Quarterly	2021-09-30	0.23	-46.5%	USD/shares	10-Q	2022-11-01
Quarterly	2022-03-31	0.14	-39.1%	USD/shares	10-Q	2023-05-03
Quarterly	2022-06-30	-0.18	-228.6%	USD/shares	10-Q	2023-08-01
Quarterly	2022-09-30	0.69	+483.3%	USD/shares	10-Q	2023-10-31
Quarterly	2023-03-31	-0.79	-214.5%	USD/shares	10-Q	2024-05-01
Quarterly	2023-06-30	0.95	+220.3%	USD/shares	10-Q	2024-08-01
Quarterly	2023-09-30	0.82	-13.7%	USD/shares	10-Q	2024-10-30
Quarterly	2024-03-31	0.42	-48.8%	USD/shares	10-Q	2025-05-05
Quarterly	2024-06-30	0.63	+50.0%	USD/shares	10-Q	2025-07-30
Quarterly	2024-09-30	1.24	+96.8%	USD/shares	10-Q	2025-10-28
Quarterly	2025-03-31	0.08	-93.5%	USD/shares	10-Q	2025-05-05
Quarterly	2025-06-30	1.06	+1225.0%	USD/shares	10-Q	2025-07-30
Quarterly	2025-09-30	2.04	+92.5%	USD/shares	10-Q	2025-10-28
Annual	2016-12-31	-1.63	—	USD/shares	10-K	2019-02-08
Annual	2017-12-31	-1.62	+0.6%	USD/shares	10-K	2020-02-07
Annual	2018-12-31	0.22	+113.6%	USD/shares	10-K	2021-02-05
Annual	2019-12-31	0.39	+77.3%	USD/shares	10-K	2022-02-11
Annual	2020-12-31	4.16	+966.7%	USD/shares	10-K	2023-02-09
Annual	2021-12-31	0.92	-77.9%	USD/shares	10-K	2024-02-09
Annual	2022-12-31	1.56	+69.6%	USD/shares	10-K	2025-02-10
Annual	2023-12-31	2.47	+58.3%	USD/shares	10-K	2026-02-11
Annual	2024-12-31	3.29	+33.2%	USD/shares	10-K	2026-02-11
Annual	2025-12-31	4.67	+41.9%	USD/shares	10-K	2026-02-11

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	741000.0	—	USD	10-Q	2017-05-09
Quarterly	2016-06-30	2984000.0	+302.7%	USD	10-Q	2017-08-03
Quarterly	2016-09-30	3761000.0	+26.0%	USD	10-Q	2017-11-01
Quarterly	2017-03-31	1362000.0	-63.8%	USD	10-Q	2018-04-30
Quarterly	2017-06-30	1759000.0	+29.1%	USD	10-Q	2018-07-31
Quarterly	2017-09-30	4563000.0	+159.4%	USD	10-Q	2018-11-05
Quarterly	2018-03-31	1800000.0	-60.6%	USD	10-Q	2019-04-29
Quarterly	2018-06-30	6443000.0	+257.9%	USD	10-Q	2019-07-29
Quarterly	2018-09-30	18802000.0	+191.8%	USD	10-Q	2019-11-04
Quarterly	2019-03-31	3900000.0	-79.3%	USD	10-Q	2020-05-06
Quarterly	2019-06-30	8400000.0	+115.4%	USD	10-Q	2020-08-03
Quarterly	2019-09-30	11900000.0	+41.7%	USD	10-Q	2020-11-09
Quarterly	2020-03-31	1300000.0	-89.1%	USD	10-Q	2021-05-05
Quarterly	2020-06-30	6000000.0	+361.5%	USD	10-Q	2021-08-03
Quarterly	2020-09-30	6400000.0	+6.7%	USD	10-Q	2021-11-01
Quarterly	2021-03-31	4500000.0	-29.7%	USD	10-Q	2022-05-04
Quarterly	2021-06-30	8800000.0	+95.6%	USD	10-Q	2022-08-04
Quarterly	2021-09-30	14500000.0	+64.8%	USD	10-Q	2022-11-01
Quarterly	2022-03-31	7600000.0	-47.6%	USD	10-Q	2023-05-03
Quarterly	2022-06-30	16400000.0	+115.8%	USD	10-Q	2023-08-01
Quarterly	2022-09-30	14700000.0	-10.4%	USD	10-Q	2023-10-31
Quarterly	2023-03-31	8500000.0	-42.2%	USD	10-Q	2024-05-01
Quarterly	2023-06-30	15300000.0	+80.0%	USD	10-Q	2024-08-01
Quarterly	2023-09-30	22900000.0	+49.7%	USD	10-Q	2024-10-30
Quarterly	2024-03-31	11200000.0	-51.1%	USD	10-Q	2025-05-05
Quarterly	2024-06-30	22800000.0	+103.6%	USD	10-Q	2025-07-30
Quarterly	2024-09-30	30900000.0	+35.5%	USD	10-Q	2025-10-28
Quarterly	2025-03-31	10700000.0	-65.4%	USD	10-Q	2025-05-05
Quarterly	2025-06-30	23200000.0	+116.8%	USD	10-Q	2025-07-30
Quarterly	2025-09-30	36400000.0	+56.9%	USD	10-Q	2025-10-28
Annual	2016-12-31	4108000.0	—	USD	10-K	2019-02-08
Annual	2017-12-31	6940000.0	+68.9%	USD	10-K	2020-02-07
Annual	2018-12-31	24800000.0	+257.3%	USD	10-K	2021-02-05
Annual	2019-12-31	14700000.0	-40.7%	USD	10-K	2022-02-11
Annual	2020-12-31	10900000.0	-25.9%	USD	10-K	2023-02-09
Annual	2021-12-31	23400000.0	+114.7%	USD	10-K	2024-02-09
Annual	2022-12-31	16500000.0	-29.5%	USD	10-K	2025-02-10
Annual	2023-12-31	28300000.0	+71.5%	USD	10-K	2026-02-11
Annual	2024-12-31	38200000.0	+35.0%	USD	10-K	2026-02-11
Annual	2025-12-31	34000000.0	-11.0%	USD	10-K	2026-02-11

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	86497000.0	—	shares	10-Q	2017-05-09
Quarterly	2016-06-30	86694000.0	+0.2%	shares	10-Q	2017-08-03
Quarterly	2016-09-30	86784000.0	+0.1%	shares	10-Q	2017-11-01
Quarterly	2017-03-31	87283000.0	+0.6%	shares	10-Q	2018-04-30
Quarterly	2017-06-30	88063.0	-99.9%	shares	10-Q	2018-07-31
Quarterly	2017-09-30	88325000.0	+100197.5%	shares	10-Q	2018-11-05
Quarterly	2018-03-31	89526000.0	+1.4%	shares	10-Q	2019-04-29
Quarterly	2018-06-30	90100000.0	+0.6%	shares	10-Q	2019-07-29
Quarterly	2018-09-30	96798000.0	+7.4%	shares	10-Q	2019-11-04
Quarterly	2019-03-31	91100000.0	-5.9%	shares	10-Q	2020-05-06
Quarterly	2019-06-30	94800000.0	+4.1%	shares	10-Q	2020-08-03
Quarterly	2019-09-30	96100000.0	+1.4%	shares	10-Q	2020-11-09
Quarterly	2020-03-31	97000000.0	+0.9%	shares	10-Q	2021-05-05
Quarterly	2020-06-30	98200000.0	+1.2%	shares	10-Q	2021-08-03
Quarterly	2020-09-30	93300000.0	-5.0%	shares	10-Q	2021-11-01
Quarterly	2021-03-31	98200000.0	+5.3%	shares	10-Q	2022-05-04
Quarterly	2021-06-30	97700000.0	-0.5%	shares	10-Q	2022-08-04
Quarterly	2021-09-30	97700000.0	+0.0%	shares	10-Q	2022-11-01
Quarterly	2022-03-31	97600000.0	-0.1%	shares	10-Q	2023-05-03
Quarterly	2022-06-30	95600000.0	-2.0%	shares	10-Q	2023-08-01
Quarterly	2022-09-30	99000000.0	+3.6%	shares	10-Q	2023-10-31
Quarterly	2023-03-31	97100000.0	-1.9%	shares	10-Q	2024-05-01
Quarterly	2023-06-30	100200000.0	+3.2%	shares	10-Q	2024-08-01
Quarterly	2023-09-30	101100000.0	+0.9%	shares	10-Q	2024-10-30
Quarterly	2024-03-31	103600000.0	+2.5%	shares	10-Q	2025-05-05
Quarterly	2024-06-30	103900000.0	+0.3%	shares	10-Q	2025-07-30
Quarterly	2024-09-30	104300000.0	+0.4%	shares	10-Q	2025-10-28
Quarterly	2025-03-31	102500000.0	-1.7%	shares	10-Q	2025-05-05
Quarterly	2025-06-30	101000000.0	-1.5%	shares	10-Q	2025-07-30
Quarterly	2025-09-30	102500000.0	+1.5%	shares	10-Q	2025-10-28
Annual	2016-12-31	86713000.0	—	shares	10-K	2019-02-08
Annual	2017-12-31	88089000.0	+1.6%	shares	10-K	2020-02-07
Annual	2018-12-31	95400000.0	+8.3%	shares	10-K	2021-02-05
Annual	2019-12-31	95700000.0	+0.3%	shares	10-K	2022-02-11
Annual	2020-12-31	97800000.0	+2.2%	shares	10-K	2023-02-09
Annual	2021-12-31	97900000.0	+0.1%	shares	10-K	2024-02-09
Annual	2022-12-31	98900000.0	+1.0%	shares	10-K	2025-02-10
Annual	2023-12-31	101000000.0	+2.1%	shares	10-K	2026-02-11
Annual	2024-12-31	103700000.0	+2.7%	shares	10-K	2026-02-11
Annual	2025-12-31	102500000.0	-1.2%	shares	10-K	2026-02-11

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

N/A

Total Liabilities (latest annual)

1,378,400,000

Current Liabilities (latest annual)

743,400,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-0.0466	—	ratio	10-Q	2017-05-09
Quarterly	2016-06-30	-0.1057	-126.6%	ratio	10-Q	2017-08-03
Quarterly	2016-09-30	-0.1049	+0.8%	ratio	10-Q	2017-11-01
Quarterly	2017-03-31	-0.3169	-202.1%	ratio	10-Q	2018-04-30
Quarterly	2017-06-30	-0.1737	+45.2%	ratio	10-Q	2018-07-31
Quarterly	2017-09-30	-0.0320	+81.6%	ratio	10-Q	2018-11-05
Quarterly	2018-03-31	-0.1147	-258.4%	ratio	10-Q	2019-11-04
Quarterly	2018-06-30	-0.0157	+86.3%	ratio	10-Q	2019-11-04
Quarterly	2018-09-30	0.1134	+824.1%	ratio	10-Q	2019-11-04
Quarterly	2019-03-31	-0.2495	-319.9%	ratio	10-Q	2020-05-06
Quarterly	2019-06-30	0.1061	+142.5%	ratio	10-Q	2020-08-03
Quarterly	2019-09-30	0.0936	-11.7%	ratio	10-Q	2020-11-09
Quarterly	2020-03-31	0.0534	-43.0%	ratio	10-Q	2021-05-05
Quarterly	2020-06-30	0.0958	+79.3%	ratio	10-Q	2021-08-03
Quarterly	2020-09-30	-0.0716	-174.8%	ratio	10-Q	2021-11-01
Quarterly	2021-03-31	0.0266	+137.2%	ratio	10-Q	2022-05-04
Quarterly	2021-06-30	0.0331	+24.2%	ratio	10-Q	2022-08-04
Quarterly	2021-09-30	0.0167	-49.4%	ratio	10-Q	2022-11-01
Quarterly	2022-03-31	0.0100	-40.2%	ratio	10-Q	2023-05-03
Quarterly	2022-06-30	-0.0119	-218.8%	ratio	10-Q	2023-08-01
Quarterly	2022-09-30	0.0443	+473.5%	ratio	10-Q	2023-10-31
Quarterly	2023-03-31	-0.0455	-202.5%	ratio	10-Q	2024-05-01
Quarterly	2023-06-30	0.0515	+213.3%	ratio	10-Q	2024-08-01
Quarterly	2023-09-30	0.0415	-19.5%	ratio	10-Q	2024-10-30
Quarterly	2024-03-31	0.0182	-56.2%	ratio	10-Q	2025-05-05
Quarterly	2024-06-30	0.0259	+42.4%	ratio	10-Q	2025-07-30
Quarterly	2024-09-30	0.0477	+84.3%	ratio	10-Q	2025-10-28
Quarterly	2025-03-31	0.0031	-93.5%	ratio	10-Q	2025-05-05
Quarterly	2025-06-30	0.0399	+1180.7%	ratio	10-Q	2025-07-30
Quarterly	2025-09-30	0.0697	+74.8%	ratio	10-Q	2025-10-28
Annual	2016-12-31	-0.4481	—	ratio	10-K	2019-02-08
Annual	2017-12-31	-0.3830	+14.5%	ratio	10-K	2020-02-07
Annual	2018-12-31	0.0439	+111.5%	ratio	10-K	2021-02-05
Annual	2019-12-31	0.0581	+32.4%	ratio	10-K	2022-02-11
Annual	2020-12-31	0.3617	+522.5%	ratio	10-K	2023-02-09
Annual	2021-12-31	0.0652	-82.0%	ratio	10-K	2024-02-09
Annual	2022-12-31	0.0905	+38.7%	ratio	10-K	2025-02-10
Annual	2023-12-31	0.1119	+23.7%	ratio	10-K	2026-02-11
Annual	2024-12-31	0.1318	+17.8%	ratio	10-K	2026-02-11
Annual	2025-12-31	0.1471	+11.6%	ratio	10-K	2026-02-11

8-K Material Event Details

55 filings · 99 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

725 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-03-04	ABERNETHY MATT	Chief Financial Officer	Equity grant / award G	Common Stock	2,249	$0.00	$0	42,808
2026-02-20	Onyia Jude	Chief Scientific Officer	Equity grant / award G	Common Stock	3,110	$0.00	$0	25,670
2026-02-13	ABERNETHY MATT	Chief Financial Officer	Equity grant / award A · derivative	Restricted Stock Unit	7,735	$0.00	$0	7,735
2026-02-13	ABERNETHY MATT	Chief Financial Officer	Equity grant / award A · derivative	Stock Option	44,095	$0.00	$0	44,095
2026-02-13	ABERNETHY MATT	Chief Financial Officer	Exercise / conversion M · derivative	Restricted Stock Unit	2,566	$0.00	$0	2,566
2026-02-13	ABERNETHY MATT	Chief Financial Officer	Exercise / conversion M · derivative	Restricted Stock Unit	2,241	$0.00	$0	4,484
2026-02-13	ABERNETHY MATT	Chief Financial Officer	Other disposed transaction F	Common Stock	5,378	$124.12	$667,517	44,881
2026-02-13	ABERNETHY MATT	Chief Financial Officer	Equity grant / award A	Common Stock	9,968	$0.00	$0	50,259
2026-02-13	ABERNETHY MATT	Chief Financial Officer	Other disposed transaction F	Common Stock	1,385	$124.12	$171,906	40,291
2026-02-13	ABERNETHY MATT	Chief Financial Officer	Exercise / conversion M	Common Stock	2,566	$0.00	$0	41,676
2026-02-13	ABERNETHY MATT	Chief Financial Officer	Other disposed transaction F	Common Stock	1,210	$124.12	$150,185	39,110
2026-02-13	ABERNETHY MATT	Chief Financial Officer	Exercise / conversion M	Common Stock	2,241	$0.00	$0	40,320
2026-02-13	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M · derivative	Restricted Stock Unit	5,377	$0.00	$0	5,377
2026-02-13	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M · derivative	Restricted Stock Unit	5,604	$0.00	$0	11,208
2026-02-13	GORMAN KEVIN CHARLES	Dir	Other disposed transaction F	Common Stock	34,380	$124.12	$4,267,246	551,293
2026-02-13	GORMAN KEVIN CHARLES	Dir	Equity grant / award A	Common Stock	63,724	$0.00	$0	585,673
2026-02-13	GORMAN KEVIN CHARLES	Dir	Other disposed transaction F	Common Stock	2,901	$124.12	$360,072	521,949
2026-02-13	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M	Common Stock	5,377	$0.00	$0	524,850
2026-02-13	GORMAN KEVIN CHARLES	Dir	Other disposed transaction F	Common Stock	3,024	$124.12	$375,339	519,473
2026-02-13	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M	Common Stock	5,604	$0.00	$0	522,497
2026-02-12	ABERNETHY MATT	Chief Financial Officer	Exercise / conversion M · derivative	Restricted Stock Unit	2,133	$0.00	$0	6,401
2026-02-12	ABERNETHY MATT	Chief Financial Officer	Other disposed transaction F	Common Stock	1,151	$123.10	$141,688	38,079
2026-02-12	ABERNETHY MATT	Chief Financial Officer	Exercise / conversion M	Common Stock	2,133	$0.00	$0	39,230
2026-01-31	Boyer David W.	Chief Corp. Affairs Officer	Exercise / conversion M · derivative	Restriced Stock Unit	2,096	$0.00	$0	0
2026-01-31	Boyer David W.	Chief Corp. Affairs Officer	Other disposed transaction F	Common Stock	1,189	$136.06	$161,775	4,713
2026-01-31	Boyer David W.	Chief Corp. Affairs Officer	Exercise / conversion M	Common Stock	2,096	$0.00	$0	5,902
2026-01-16	Gano Kyle	Chief Executive Officer	Exercise / conversion M · derivative	Incentive Stock Option	1,812	$0.00	$0	0
2026-01-16	Gano Kyle	Chief Executive Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	34,588	$0.00	$0	0
2026-01-16	Gano Kyle	Chief Executive Officer	Open-market sell S	Common Stock	1,812	$132.71	$240,478	140,407
2026-01-16	Gano Kyle	Chief Executive Officer	Exercise / conversion M	Common Stock	1,812	$35.99	$65,214	142,219
2026-01-16	Gano Kyle	Chief Executive Officer	Open-market sell S	Common Stock	34,588	$132.70	$4,589,980	140,407
2026-01-16	Gano Kyle	Chief Executive Officer	Exercise / conversion M	Common Stock	34,588	$35.99	$1,244,822	174,995
2026-01-08	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Incentive Stock Option	3,349	$0.00	$0	0
2026-01-08	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	3,349	$35.99	$120,531	46,754
2025-12-16	Norwalk Leslie V	Dir	Open-market sell S	Common Stock	1,190	$155.09	$184,558	6,239
2025-12-15	Norwalk Leslie V	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,724	$0.00	$0	0
2025-12-15	Norwalk Leslie V	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	8,276	$0.00	$0	557
2025-12-15	Norwalk Leslie V	Dir	Open-market sell S	Common Stock	5,000	$152.23	$761,144	7,429
2025-12-15	Norwalk Leslie V	Dir	Exercise / conversion M	Common Stock	1,724	$84.95	$146,454	12,429
2025-12-15	Norwalk Leslie V	Dir	Exercise / conversion M	Common Stock	8,276	$92.35	$764,289	10,705
2025-12-08	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	4,376	$0.00	$0	0
2025-12-08	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	4,376	$159.65	$698,615	43,405
2025-12-08	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	4,376	$43.24	$189,218	47,781
2025-12-03	LYONS GARY A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$0.00	$0	0
2025-12-03	LYONS GARY A	Dir	Open-market sell S	Common Stock	15,000	$152.61	$2,289,082	120,482
2025-12-03	LYONS GARY A	Dir	Exercise / conversion M	Common Stock	15,000	$47.89	$718,350	135,482
2025-11-29	Onyia Jude	Chief Scientific Officer	Exercise / conversion M · derivative	Restricted Stock Unit	4,426	$0.00	$0	0
2025-11-29	Onyia Jude	Chief Scientific Officer	Other disposed transaction F	Common Stock	2,248	$152.16	$342,056	15,881
2025-11-29	Onyia Jude	Chief Scientific Officer	Exercise / conversion M	Common Stock	4,426	$0.00	$0	18,129
2025-11-28	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Incentive Stock Option	5,970	$0.00	$0	6,860
2025-11-28	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	5,970	$151.74	$905,881	44,893
2025-11-28	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	5,970	$35.99	$214,860	50,863
2025-11-28	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Incentive Stock Option	12,830	$0.00	$0	0
2025-11-28	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	12,830	$35.99	$461,752	57,723
2025-11-25	MORROW GEORGE J	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$0.00	$0	0
2025-11-25	MORROW GEORGE J	Dir	Open-market sell S	Common Stock	15,000	$143.37	$2,150,512	7,068
2025-11-25	MORROW GEORGE J	Dir	Exercise / conversion M	Common Stock	15,000	$47.89	$718,350	22,068
2025-11-05	RASTETTER WILLIAM H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	18,000	$0.00	$0	0
2025-11-05	RASTETTER WILLIAM H	Dir	Open-market sell S	Common Stock	18,000	$151.82	$2,732,690	40,360
2025-11-05	RASTETTER WILLIAM H	Dir	Exercise / conversion M	Common Stock	18,000	$47.89	$862,020	58,360
2025-11-04	Gano Kyle	Chief Executive Officer	Open-market sell S	Common Stock	300	$141.97	$42,591	140,407
2025-11-01	Gano Kyle	Chief Executive Officer	Exercise / conversion M · derivative	Restricted Stock Unit	613	$0.00	$0	1,842
2025-11-01	Gano Kyle	Chief Executive Officer	Exercise / conversion M	Common Stock	613	$0.00	$0	140,720
2025-09-03	Onyia Jude	Chief Scientific Officer	Equity grant / award G	Common Stock	1,470	$0.00	$0	13,703
2025-09-02	SHERWIN STEPHEN A	Dir	Equity grant / award G	Common Stock	1,000	$0.00	$0	12,542
2025-08-07	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	106,322	$0.00	$0	0
2025-08-07	GORMAN KEVIN CHARLES	Dir	Open-market sell S	Common Stock	106,322	$126.41	$13,440,281	514,596
2025-08-07	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M	Common Stock	106,322	$35.99	$3,826,529	620,918
2025-08-05	Onyia Jude	Chief Scientific Officer	Equity grant / award G	Common Stock	3,116	$0.00	$0	15,173
2025-07-10	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	457	$0.00	$0	2,261
2025-07-10	Delaet Ingrid	Chief Regulatory Officer	Open-market sell S	Common Stock	457	$135.00	$61,695	4,730
2025-07-10	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M	Common Stock	457	$79.02	$36,112	5,187
2025-07-09	Onyia Jude	Chief Scientific Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	59,819	$0.00	$0	35,268
2025-07-09	Onyia Jude	Chief Scientific Officer	Open-market sell S	Common Stock	59,819	$130.46	$7,803,688	18,289
2025-07-09	Onyia Jude	Chief Scientific Officer	Exercise / conversion M	Common Stock	59,819	$84.74	$5,069,062	78,108
2025-07-02	Onyia Jude	Chief Scientific Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	20,362	$0.00	$0	95,087
2025-07-02	Onyia Jude	Chief Scientific Officer	Open-market sell S	Common Stock	20,362	$130.13	$2,649,738	18,289
2025-07-02	Onyia Jude	Chief Scientific Officer	Exercise / conversion M	Common Stock	20,362	$84.74	$1,725,476	38,651
2025-06-02	Keswani Sanjay Chandru	Chief Medical Officer	Equity grant / award A · derivative	Stock Option	70,101	$0.00	$0	70,101
2025-06-02	Keswani Sanjay Chandru	Chief Medical Officer	Equity grant / award A · derivative	Restricted Stock Unit	12,846	$0.00	$0	12,846
2025-05-27	GORMAN KEVIN CHARLES	Dir	Open-market sell S	Common Stock	9,613	$120.38	$1,157,211	514,596
2025-05-22	RASTETTER WILLIAM H	Dir	Exercise / conversion M · derivative	Restricted Stock Unit	2,869	$0.00	$0	0
2025-05-22	RASTETTER WILLIAM H	Dir	Exercise / conversion M	Common Stock	2,869	$0.00	$0	40,360
2025-05-21	RASTETTER WILLIAM H	Dir	Equity grant / award A · derivative	Restricted Stock Unit	3,318	$0.00	$0	3,318
2025-05-16	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M · derivative	Incentive Stock Option	6,468	$0.00	$0	0
2025-05-16	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M	Common Stock	6,468	$61.82	$399,852	26,858
2025-05-05	RASTETTER WILLIAM H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	30,000	$0.00	$0	0
2025-05-05	RASTETTER WILLIAM H	Dir	Open-market sell S	Common Stock	30,000	$110.20	$3,305,952	37,491
2025-05-05	RASTETTER WILLIAM H	Dir	Exercise / conversion M	Common Stock	30,000	$42.76	$1,282,800	67,491
2025-02-13	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M · derivative	Restricted Stock Unit	1,401	$0.00	$0	4,203
2025-02-13	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M · derivative	Restricted Stock Unit	1,509	$0.00	$0	3,020
2025-02-13	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	755	$116.80	$88,183	20,190
2025-02-13	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M	Common Stock	1,401	$0.00	$0	20,945
2025-02-13	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	796	$116.77	$92,946	19,544
2025-02-13	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M	Common Stock	1,509	$0.00	$0	20,340
2025-02-13	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M · derivative	Restricted Stock Unit	5,603	$0.00	$0	16,812
2025-02-13	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M · derivative	Restricted Stock Unit	5,376	$0.00	$0	10,754
2025-02-13	GORMAN KEVIN CHARLES	Dir	Open-market sell S	Common Stock	3,012	$116.68	$351,450	524,209
2025-02-13	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M	Common Stock	5,603	$0.00	$0	527,221
2025-02-13	GORMAN KEVIN CHARLES	Dir	Open-market sell S	Common Stock	2,832	$116.69	$330,465	521,618
2025-02-13	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M	Common Stock	5,376	$0.00	$0	524,450
2025-02-12	Cooke Julie	Chief Human Resources Officer	Equity grant / award A · derivative	Restricted Stock Unit	5,548	$0.00	$0	5,548
2025-02-12	Cooke Julie	Chief Human Resources Officer	Equity grant / award A · derivative	Stock Option	29,600	$0.00	$0	29,600
2025-02-10	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	700	$118.28	$82,792	18,831
2025-02-08	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M · derivative	Restricted Stock Unit	1,329	$0.00	$0	0
2025-02-08	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M	Common Stock	1,329	$0.00	$0	19,531
2025-01-31	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M · derivative	Restricted Stock Unit	1,740	$0.00	$0	1,741
2025-01-31	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	824	$152.89	$125,980	18,202
2025-01-31	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	916	$152.89	$140,045	19,026
2025-01-31	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M	Common Stock	1,740	$0.00	$0	19,942
2025-01-27	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	146,105	$0.00	$0	0
2025-01-27	GORMAN KEVIN CHARLES	Dir	Open-market sell S	Common Stock	146,105	$149.46	$21,836,503	514,596
2025-01-27	GORMAN KEVIN CHARLES	Dir	Exercise / conversion M	Common Stock	146,105	$32.99	$4,820,004	660,701
2025-01-15	Gano Kyle	Chief Executive Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	60,188	$0.00	$0	0
2025-01-15	Gano Kyle	Chief Executive Officer	Exercise / conversion M · derivative	Incentive Stock Option	4,812	$0.00	$0	0
2025-01-15	Gano Kyle	Chief Executive Officer	Open-market sell S	Common Stock	60,188	$141.50	$8,516,656	135,392
2025-01-15	Gano Kyle	Chief Executive Officer	Exercise / conversion M	Common Stock	60,188	$32.99	$1,985,602	195,580
2025-01-15	Gano Kyle	Chief Executive Officer	Open-market sell S	Common Stock	4,812	$141.50	$680,894	135,392
2025-01-15	Gano Kyle	Chief Executive Officer	Exercise / conversion M	Common Stock	4,812	$32.99	$158,748	140,204
2024-12-31	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	272	$0.00	$0	2,718
2024-12-31	Delaet Ingrid	Chief Regulatory Officer	Open-market sell S	Common Stock	272	$138.10	$37,563	2,507
2024-12-31	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M	Common Stock	272	$79.02	$21,493	2,779
2024-12-17	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Stock Option	27,770	$0.00	$0	27,770
2024-12-17	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Restricted Stock Unit	5,487	$0.00	$0	5,487
2024-11-29	Onyia Jude	Chief Scientific Officer	Exercise / conversion M · derivative	Restricted Stock Unit	4,426	$0.00	$0	4,426
2024-11-29	Onyia Jude	Chief Scientific Officer	Open-market sell S	Common Stock	2,331	$126.29	$294,373	15,449
2024-11-29	Onyia Jude	Chief Scientific Officer	Exercise / conversion M	Common Stock	4,426	$0.00	$0	17,780
2024-11-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Incentive Stock Option	1	$0.00	$0	1,265
2024-11-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Incentive Stock Option	971	$0.00	$0	0
2024-11-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Incentive Stock Option	1,233	$0.00	$0	0
2024-11-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Incentive Stock Option	5,140	$0.00	$0	0
2024-11-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	1	$79.02	$79	31,061
2024-11-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	971	$102.90	$99,916	31,060
2024-11-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	1,233	$81.05	$99,935	30,089
2024-11-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	5,140	$77.81	$399,943	28,856
2024-11-04	SHERWIN STEPHEN A	Dir	Equity grant / award G	Common Stock	2,000	$0.00	$0	24,504
2024-11-01	Gano Kyle	Chief Executive Officer	Equity grant / award A · derivative	Stock Option	13,344	$0.00	$0	13,344
2024-11-01	Gano Kyle	Chief Executive Officer	Equity grant / award A · derivative	Restricted Stock Unit	2,455	$0.00	$0	2,455
2024-10-03	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	1,295	$113.66	$147,190	377
2024-09-13	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	3,461	$121.88	$421,828	1,672
2024-08-15	RASTETTER WILLIAM H	Dir	Open-market sell S	Common Stock	14,250	$146.69	$2,090,332	37,491
2024-08-13	LYONS GARY A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	11,570	$0.00	$0	0
2024-08-13	LYONS GARY A	Dir	Open-market sell S	Common Stock	11,570	$150.43	$1,740,450	119,047
2024-08-13	LYONS GARY A	Dir	Exercise / conversion M	Common Stock	11,570	$42.76	$494,733	130,617
2024-08-06	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	273	$0.00	$0	4,081
2024-08-06	Delaet Ingrid	Chief Regulatory Officer	Open-market sell S	Common Stock	273	$147.70	$40,322	6,607
2024-08-06	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M	Common Stock	273	$79.02	$21,572	6,880
2024-08-01	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	12,632	$0.00	$0	0
2024-08-01	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	12,632	$153.26	$1,936,017	18,202
2024-08-01	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M	Common Stock	12,632	$61.82	$780,910	30,834
2024-07-16	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	900	$0.00	$0	12,632
2024-07-16	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	900	$150.04	$135,036	18,202
2024-07-16	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M	Common Stock	900	$61.82	$55,638	19,102
2024-07-01	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	10,000	$0.00	$0	13,532
2024-07-01	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	10,000	$140.19	$1,401,864	18,202
2024-07-01	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M	Common Stock	10,000	$61.82	$618,200	28,202
2024-05-31	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	273	$0.00	$0	4,626
2024-05-31	Delaet Ingrid	Chief Regulatory Officer	Open-market sell S	Common Stock	273	$136.55	$37,278	7,507
2024-05-31	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M	Common Stock	273	$79.02	$21,572	7,780
2024-05-29	SHERWIN STEPHEN A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$0.00	$0	0
2024-05-29	SHERWIN STEPHEN A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	25,000	$0.00	$0	0
2024-05-29	SHERWIN STEPHEN A	Dir	Open-market sell S	Common Stock	15,000	$133.47	$2,002,010	26,504
2024-05-29	SHERWIN STEPHEN A	Dir	Exercise / conversion M	Common Stock	15,000	$47.89	$718,350	41,504
2024-05-29	SHERWIN STEPHEN A	Dir	Open-market sell S	Common Stock	25,000	$133.46	$3,336,555	26,504
2024-05-29	SHERWIN STEPHEN A	Dir	Exercise / conversion M	Common Stock	25,000	$42.76	$1,069,000	51,504
2024-05-22	RASTETTER WILLIAM H	Dir	Equity grant / award A · derivative	Restricted Stock Unit	2,869	$0.00	$0	2,869
2024-05-17	Sharp Shalini	Dir	Exercise / conversion M · derivative	Restricted Stock Unit	2,100	$0.00	$0	0
2024-05-17	Sharp Shalini	Dir	Open-market sell S	Common Stock	1,106	$141.90	$156,943	994
2024-05-17	Sharp Shalini	Dir	Exercise / conversion M	Common Stock	2,100	$0.00	$0	2,100
2024-05-14	LYONS GARY A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	12,500	$42.76	$534,500	12,500
2024-05-14	LYONS GARY A	Dir	Open-market sell S	Common Stock	12,500	$135.63	$1,695,370	116,947
2024-05-14	LYONS GARY A	Dir	Exercise / conversion M	Common Stock	12,500	$42.76	$534,500	129,447
2024-05-06	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	273	$79.02	$21,572	4,899
2024-05-06	Delaet Ingrid	Chief Regulatory Officer	Open-market sell S	Common Stock	273	$140.55	$38,370	7,507
2024-05-06	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M	Common Stock	273	$79.02	$21,572	7,780
2024-04-15	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	12,587	$81.05	$1,020,176	0
2024-04-15	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	7,231	$81.49	$589,254	26,292
2024-04-15	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	12,587	$133.36	$1,678,660	40,778
2024-04-15	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	12,587	$81.05	$1,020,176	53,365
2024-04-15	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	7,231	$133.36	$964,359	40,778
2024-04-15	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	7,231	$81.49	$589,254	48,009
2024-04-01	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	272	$79.02	$21,493	5,172
2024-04-01	Delaet Ingrid	Chief Regulatory Officer	Open-market sell S	Common Stock	272	$137.30	$37,346	7,507
2024-04-01	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M	Common Stock	272	$79.02	$21,493	7,779
2024-03-21	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	5,000	$103.52	$517,600	27,049
2024-03-21	Delaet Ingrid	Chief Regulatory Officer	Open-market sell S	Common Stock	5,000	$145.06	$725,320	7,507
2024-03-21	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M	Common Stock	5,000	$103.52	$517,600	12,507
2024-03-14	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	69,521	$81.05	$5,634,677	12,587
2024-03-14	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	5,479	$79.02	$432,951	33,881
2024-03-14	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	69,521	$139.38	$9,689,761	40,778
2024-03-14	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	69,521	$81.05	$5,634,677	110,299
2024-03-14	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	5,479	$139.38	$763,657	40,778
2024-03-14	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	5,479	$79.02	$432,951	46,257
2024-03-13	POPS RICHARD F	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	23,200	$42.76	$992,032	0
2024-03-13	POPS RICHARD F	Dir	Open-market sell S	Common Stock	23,200	$140.33	$3,255,621	29,512
2024-03-13	POPS RICHARD F	Dir	Exercise / conversion M	Common Stock	23,200	$42.76	$992,032	52,712
2024-03-11	POPS RICHARD F	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	100	$42.76	$4,276	23,200
2024-03-11	POPS RICHARD F	Dir	Open-market sell S	Common Stock	100	$140.00	$14,000	29,512
2024-03-11	POPS RICHARD F	Dir	Exercise / conversion M	Common Stock	100	$42.76	$4,276	29,612
2024-03-08	POPS RICHARD F	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,700	$42.76	$72,692	23,300
2024-03-08	POPS RICHARD F	Dir	Open-market sell S	Common Stock	1,700	$140.05	$238,078	29,512
2024-03-08	POPS RICHARD F	Dir	Exercise / conversion M	Common Stock	1,700	$42.76	$72,692	31,212
2024-02-29	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	273	$79.02	$21,572	5,444
2024-02-29	Delaet Ingrid	Chief Regulatory Officer	Open-market sell S	Common Stock	273	$135.51	$36,994	7,507
2024-02-29	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M	Common Stock	273	$79.02	$21,572	7,780
2024-02-28	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,544	$79.02	$122,007	5,717
2024-02-28	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	2,500	$79.02	$197,550	7,261
2024-02-28	Delaet Ingrid	Chief Regulatory Officer	Open-market sell S	Common Stock	1,544	$136.00	$209,984	7,507
2024-02-28	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M	Common Stock	1,544	$79.02	$122,007	9,051
2024-02-28	Delaet Ingrid	Chief Regulatory Officer	Open-market sell S	Common Stock	2,500	$134.62	$336,550	7,507
2024-02-28	Delaet Ingrid	Chief Regulatory Officer	Exercise / conversion M	Common Stock	2,500	$79.02	$197,550	10,007
2024-02-27	Norwalk Leslie V	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	8,000	$84.95	$679,600	1,724
2024-02-27	Norwalk Leslie V	Dir	Open-market sell S	Common Stock	8,000	$135.67	$1,085,388	0
2024-02-27	Norwalk Leslie V	Dir	Exercise / conversion M	Common Stock	8,000	$84.95	$679,600	8,000
2024-02-20	POPS RICHARD F	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$12.98	$194,700	0
2024-02-20	POPS RICHARD F	Dir	Open-market sell S	Common Stock	15,000	$132.47	$1,987,047	29,512
2024-02-20	POPS RICHARD F	Dir	Exercise / conversion M	Common Stock	15,000	$12.98	$194,700	44,512
2024-02-13	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Restricted Stock Unit	4,483	$0.00	$0	4,483
2024-02-13	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Stock Option	22,529	$0.00	$0	22,529
2024-02-13	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	1,114	$132.96	$148,122	23,716
2024-02-08	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	628	$136.78	$85,898	4,895
2024-02-08	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	700	$134.19	$93,932	5,523
2024-02-06	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	216	$141.96	$30,663	4,894
2024-02-06	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	240	$141.96	$34,070	5,110
2024-01-31	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	1,457	$140.79	$205,132	20,832
2024-01-22	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	10,000	$79.02	$790,200	53,372
2024-01-22	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	10,000	$139.86	$1,398,553	35,882
2024-01-22	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	10,000	$79.02	$790,200	45,882
2024-01-09	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	62,023	$19.59	$1,215,031	0
2024-01-09	GORMAN KEVIN CHARLES	Chief Executive Officer	Open-market sell S	Common Stock	62,023	$134.01	$8,311,894	499,754
2024-01-09	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M	Common Stock	62,023	$19.59	$1,215,031	561,777
2024-01-08	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	105,835	$19.59	$2,073,308	62,023
2024-01-08	GORMAN KEVIN CHARLES	Chief Executive Officer	Open-market sell S	Common Stock	105,835	$132.44	$14,016,523	499,754
2024-01-08	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M	Common Stock	105,835	$19.59	$2,073,308	605,589
2024-01-02	Gano Kyle	Chief Business Development Off	Exercise / conversion M · derivative	Incentive Stock Option	6,116	$19.59	$119,812	0
2024-01-02	Gano Kyle	Chief Business Development Off	Exercise / conversion M · derivative	Non-Qualified Stock Option	68,884	$19.59	$1,349,438	0
2024-01-02	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	6,116	$131.44	$803,905	130,250
2024-01-02	Gano Kyle	Chief Business Development Off	Exercise / conversion M	Common Stock	6,116	$19.59	$119,812	136,366
2024-01-02	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	68,884	$131.47	$9,056,290	130,250
2024-01-02	Gano Kyle	Chief Business Development Off	Exercise / conversion M	Common Stock	68,884	$19.59	$1,349,438	199,134
2023-12-22	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	10,000	$126.74	$1,267,448	19,521
2023-12-12	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	6,947	$81.05	$563,054	39,440
2023-12-12	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	6,978	$81.05	$565,567	46,387
2023-12-12	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	6,947	$120.31	$835,779	29,521
2023-12-12	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	6,947	$81.05	$563,054	36,468
2023-12-12	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	6,978	$120.30	$839,461	29,521
2023-12-12	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	6,978	$81.05	$565,567	36,499
2023-12-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	100	$81.05	$8,105	53,365
2023-12-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	200	$81.05	$16,210	53,465
2023-12-08	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	100	$120.00	$12,000	29,521
2023-12-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	100	$81.05	$8,105	29,621
2023-12-08	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	200	$120.16	$24,031	29,521
2023-12-08	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	200	$81.05	$16,210	29,721
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	11,775	$81.05	$954,364	53,665
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	14,140	$79.02	$1,117,343	60,005
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	12,742	$77.81	$991,455	0
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	38,722	$77.81	$3,012,959	12,742
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	11,775	$120.37	$1,417,374	29,521
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	11,775	$81.05	$954,364	41,296
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	14,140	$120.37	$1,702,053	29,521
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	14,140	$79.02	$1,117,343	43,661
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	12,742	$120.37	$1,533,774	29,521
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	12,742	$77.81	$991,455	42,263
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	38,722	$120.37	$4,661,118	29,521
2023-12-07	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	38,722	$77.81	$3,012,959	68,243
2023-12-06	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	8,396	$77.81	$653,293	51,464
2023-12-06	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	8,396	$120.03	$1,007,780	29,521
2023-12-06	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	8,396	$77.81	$653,293	37,917
2023-12-01	LYONS GARY A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	5,000	$12.98	$64,900	0
2023-12-01	LYONS GARY A	Dir	Open-market sell S	Common Stock	5,000	$116.77	$583,837	203,697
2023-12-01	LYONS GARY A	Dir	Exercise / conversion M	Common Stock	5,000	$12.98	$64,900	208,697
2023-11-29	Onyia Jude	Chief Scientific Officer	Open-market sell S	Common Stock	2,331	$113.57	$264,733	11,732
2023-11-27	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	10,919	$112.27	$1,225,911	35,882
2023-11-16	SHERWIN STEPHEN A	Dir	Equity grant / award G	Common Stock	2,750	$0.00	$0	22,305
2023-10-02	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	1,437	$112.68	$161,921	4,894
2023-09-12	LYONS GARY A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	5,000	$12.98	$64,900	5,000
2023-09-12	LYONS GARY A	Dir	Open-market sell S	Common Stock	5,000	$115.02	$575,120	203,697
2023-09-12	LYONS GARY A	Dir	Exercise / conversion M	Common Stock	5,000	$12.98	$64,900	208,697
2023-09-01	LYONS GARY A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	5,000	$12.98	$64,900	10,000
2023-09-01	LYONS GARY A	Dir	Open-market sell S	Common Stock	5,000	$110.06	$550,316	203,697
2023-09-01	LYONS GARY A	Dir	Exercise / conversion M	Common Stock	5,000	$12.98	$64,900	208,697
2023-08-30	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	1,438	$108.22	$155,623	3,460
2023-08-30	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	1,295	$106.90	$138,436	4,898
2023-08-28	Delaet Ingrid	Chief Regulatory Officer	Open-market sell S	Common Stock	1,431	$107.52	$153,861	5,931
2023-08-21	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	3,198	$107.38	$343,388	29,521
2023-07-11	POON CHRISTINE A	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option	16,375	$0.00	$0	16,375
2023-05-17	SHERWIN STEPHEN A	Dir	Equity grant / award A · derivative	Restricted Stock Unit	4,199	$0.00	$0	4,199
2023-05-01	RASTETTER WILLIAM H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	7,625	$12.71	$96,914	0
2023-05-01	RASTETTER WILLIAM H	Dir	Open-market sell S	Common Stock	4,300	$101.43	$436,135	42,785
2023-05-01	RASTETTER WILLIAM H	Dir	Exercise / conversion M	Common Stock	7,625	$12.71	$96,914	47,085
2023-04-25	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	100	$103.82	$10,382	27,561
2023-04-24	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	14,400	$103.48	$1,490,059	26,644
2023-04-21	RASTETTER WILLIAM H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	10,765	$12.71	$136,823	7,625
2023-04-21	RASTETTER WILLIAM H	Dir	Open-market sell S	Common Stock	6,034	$105.04	$633,787	39,460
2023-04-21	RASTETTER WILLIAM H	Dir	Exercise / conversion M	Common Stock	10,765	$12.71	$136,823	45,494
2023-04-19	RASTETTER WILLIAM H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,610	$12.71	$20,463	18,390
2023-04-19	RASTETTER WILLIAM H	Dir	Open-market sell S	Common Stock	903	$105.00	$94,819	34,729
2023-04-19	RASTETTER WILLIAM H	Dir	Exercise / conversion M	Common Stock	1,610	$12.71	$20,463	35,632
2023-02-23	NEUROCRINE BIOSCIENCES INC	10%	Open-market buy P	Common Stock	4,395,588	$8.88	$39,032,821	8,575,316
2023-02-13	Delaet Ingrid	Chief Regulatory Officer	Equity grant / award A · derivative	Restricted Stock Unit	5,434	$0.00	$0	5,434
2023-02-13	Delaet Ingrid	Chief Regulatory Officer	Equity grant / award A · derivative	Stock Option	33,771	$0.00	$0	33,771
2023-02-08	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	628	$103.69	$65,117	27,424
2023-02-08	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	700	$103.95	$72,766	28,052
2023-02-07	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	822	$104.03	$85,513	27,424
2023-02-07	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	12,801	$102.41	$1,310,916	28,246
2023-02-07	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	913	$102.25	$93,350	16,749
2023-02-07	Onyia Jude	Chief Scientific Officer	Open-market sell S	Common Stock	4,508	$102.30	$461,166	6,525
2023-02-06	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	575	$104.28	$59,961	15,926
2023-02-06	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	640	$105.47	$67,498	16,501
2023-01-31	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	1,457	$109.99	$160,254	26,171
2023-01-06	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	400	$43.24	$17,296	53,143
2023-01-06	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	400	$125.00	$50,000	15,643
2023-01-06	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	400	$43.24	$17,296	16,043
2023-01-03	SHERWIN STEPHEN A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$12.98	$194,700	0
2023-01-03	SHERWIN STEPHEN A	Dir	Open-market sell S	Common Stock	15,000	$118.85	$1,782,752	25,055
2023-01-03	SHERWIN STEPHEN A	Dir	Exercise / conversion M	Common Stock	15,000	$12.98	$194,700	40,055
2022-11-30	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	20,063	$43.24	$867,524	53,543
2022-11-30	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	7,775	$35.99	$279,822	0
2022-11-30	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	22,162	$41.78	$925,928	0
2022-11-30	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	20,063	$125.90	$2,525,966	15,643
2022-11-30	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	20,063	$43.24	$867,524	35,706
2022-11-30	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	7,775	$125.90	$978,886	15,643
2022-11-30	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	7,775	$35.99	$279,822	23,418
2022-11-30	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	22,162	$125.90	$2,790,233	15,643
2022-11-30	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	22,162	$41.78	$925,928	37,805
2022-11-29	Onyia Jude	Chief Scientific Officer	Open-market sell S	Common Stock	2,331	$121.90	$284,160	2,366
2022-11-10	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	100	$41.78	$4,178	22,162
2022-11-10	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	100	$125.36	$12,536	15,643
2022-11-10	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	100	$41.78	$4,178	15,743
2022-11-08	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	24,593	$41.78	$1,027,496	22,262
2022-11-08	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	24,593	$125.33	$3,082,319	15,643
2022-11-08	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	24,593	$41.78	$1,027,496	40,236
2022-11-03	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	4,518	$43.24	$195,358	30,288
2022-11-03	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	4,518	$125.02	$564,851	29,234
2022-11-03	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	4,518	$43.24	$195,358	33,752
2022-11-03	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	7,264	$81.05	$588,747	27,721
2022-11-03	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	7,264	$125.00	$908,034	15,102
2022-11-03	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M	Common Stock	7,264	$81.05	$588,747	22,366
2022-11-02	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	400	$43.24	$17,296	34,806
2022-11-02	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	400	$125.00	$50,000	29,234
2022-11-02	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	400	$43.24	$17,296	29,634
2022-11-02	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,144	$81.05	$92,721	34,985
2022-11-02	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	1,144	$124.97	$142,963	15,102
2022-11-02	Cooke Julie	Chief Human Resources Officer	Exercise / conversion M	Common Stock	1,144	$81.05	$92,721	16,246
2022-11-01	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	10,000	$43.24	$432,400	35,206
2022-11-01	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	10,000	$120.09	$1,200,899	29,234
2022-11-01	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	10,000	$43.24	$432,400	39,234
2022-10-31	LYONS GARY A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$12.71	$190,650	0
2022-10-31	LYONS GARY A	Dir	Open-market sell S	Common Stock	15,000	$114.76	$1,721,403	203,697
2022-10-31	LYONS GARY A	Dir	Exercise / conversion M	Common Stock	15,000	$12.71	$190,650	218,697
2022-10-27	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	4,923	$43.24	$212,871	45,206
2022-10-27	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	4,923	$115.04	$566,332	29,234
2022-10-27	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	4,923	$43.24	$212,871	34,157
2022-10-26	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	5,077	$43.24	$219,529	50,129
2022-10-26	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	5,077	$115.02	$583,966	29,234
2022-10-26	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	5,077	$43.24	$219,529	34,311
2022-10-17	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	4,960	$110.82	$549,682	15,643
2022-10-04	LYONS GARY A	Dir	Open-market sell S	Common Stock	5,000	$110.54	$552,711	203,697
2022-10-03	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	1,437	$106.59	$153,170	4,214
2022-09-08	Lippoldt Darin	Chief Legal Officer	Equity grant / award G	Common Stock	100	$0.00	$0	29,234
2022-09-07	Lippoldt Darin	Chief Legal Officer	Equity grant / award G	Common Stock	100	$0.00	$0	29,334
2022-08-15	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M · derivative	Incentive Stock Option	1,227	$81.49	$99,988	0
2022-08-15	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M · derivative	Incentive Stock Option	3,361	$43.24	$145,330	0
2022-08-15	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M · derivative	Incentive Stock Option	3,455	$35.99	$124,345	0
2022-08-15	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M	Common Stock	1,227	$81.49	$99,988	26,931
2022-08-15	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M	Common Stock	3,361	$43.24	$145,330	25,704
2022-08-15	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M	Common Stock	3,455	$35.99	$124,345	22,343
2022-08-12	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	21,533	$35.99	$774,973	0
2022-08-12	Lloyd-Smith Malcolm	Chief Regulatory Officer	Open-market sell S	Common Stock	21,533	$105.95	$2,281,331	18,888
2022-08-12	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M	Common Stock	21,533	$35.99	$774,973	40,421
2022-08-05	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	1,816	$100.00	$181,600	15,102
2022-06-27	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	754	$100.00	$75,400	16,918
2022-05-18	SHERWIN STEPHEN A	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option	9,724	$0.00	$0	9,724
2022-05-09	POPS RICHARD F	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	7,500	$6.66	$49,950	0
2022-05-09	POPS RICHARD F	Dir	Open-market sell S	Common Stock	7,500	$76.30	$572,252	29,512
2022-05-09	POPS RICHARD F	Dir	Exercise / conversion M	Common Stock	7,500	$6.66	$49,950	37,012
2022-04-25	LYONS GARY A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$6.66	$99,900	0
2022-04-25	LYONS GARY A	Dir	Open-market sell S	Common Stock	15,000	$92.76	$1,391,392	208,697
2022-04-25	LYONS GARY A	Dir	Exercise / conversion M	Common Stock	15,000	$6.66	$99,900	223,697
2022-04-01	RASTETTER WILLIAM H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	20,000	$6.66	$133,200	0
2022-04-01	RASTETTER WILLIAM H	Dir	Open-market sell S	Common Stock	10,728	$94.93	$1,018,366	34,022
2022-04-01	RASTETTER WILLIAM H	Dir	Exercise / conversion M	Common Stock	20,000	$6.66	$133,200	44,750
2022-03-22	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	8,455	$95.05	$803,656	29,396
2022-03-18	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	300	$95.00	$28,500	37,851
2022-02-08	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	700	$79.62	$55,736	2,919
2022-02-07	Boyer David W.	Chief Corp. Affairs Officer	Open-market sell S	Common Stock	240	$81.07	$19,457	2,291
2022-01-31	Lloyd-Smith Malcolm	Chief Regulatory Officer	Equity grant / award A · derivative	Restricted Stock Unit	3,164	$0.00	$0	3,164
2022-01-31	Lloyd-Smith Malcolm	Chief Regulatory Officer	Equity grant / award A · derivative	Stock Option	21,546	$0.00	$0	21,546
2022-01-24	SHERWIN STEPHEN A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$6.66	$99,900	0
2022-01-24	SHERWIN STEPHEN A	Dir	Open-market sell S	Common Stock	15,000	$74.43	$1,116,378	25,055
2022-01-24	SHERWIN STEPHEN A	Dir	Exercise / conversion M	Common Stock	15,000	$6.66	$99,900	40,055
2022-01-10	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	2,632	$74.50	$196,088	21,279
2022-01-05	Gano Kyle	Chief Business Development Off	Exercise / conversion M · derivative	Non-Qualified Stock Option	28,266	$8.66	$244,784	0
2022-01-05	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	28,266	$85.50	$2,416,751	104,984
2022-01-05	Gano Kyle	Chief Business Development Off	Exercise / conversion M	Common Stock	28,266	$8.66	$244,784	133,250
2021-12-14	SHERWIN STEPHEN A	Dir	Equity grant / award G	Common Stock	2,000	$0.00	$0	25,055
2021-12-10	Lippoldt Darin	Chief Legal Officer	Equity grant / award G	Common Stock	120	$0.00	$0	34,448
2021-12-01	ABERNETHY MATT	Chief Financial Officer	Open-market sell S	Common Stock	1,645	$82.59	$135,852	16,349
2021-11-29	Onyia Jude	Chief Scientific Officer	Equity grant / award A · derivative	Restricted Stock Unit	17,702	$0.00	$0	17,702
2021-11-29	Onyia Jude	Chief Scientific Officer	Equity grant / award A · derivative	Stock Option	120,169	$0.00	$0	120,169
2021-10-07	LYONS GARY A	Dir	Open-market sell S	Common Stock	5,000	$105.06	$525,294	208,697
2021-10-04	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	987	$101.73	$100,408	14,841
2021-08-16	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	5,628	$89.62	$504,395	15,608
2021-07-27	Lloyd-Smith Malcolm	Chief Regulatory Officer	Open-market sell S	Common Stock	16,709	$93.80	$1,567,336	15,801
2021-06-10	LYONS GARY A	Dir	Open-market sell S	Common Stock	10,000	$100.27	$1,002,743	213,697
2021-05-19	Sharp Shalini	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option	8,833	$0.00	$0	8,833
2021-04-15	Mercier Johanna	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option	17,180	$0.00	$0	17,180
2021-02-10	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,700	$35.99	$61,183	21,533
2021-02-10	Lloyd-Smith Malcolm	Chief Regulatory Officer	Open-market sell S	Common Stock	600	$119.95	$71,973	32,510
2021-02-10	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M	Common Stock	600	$35.99	$21,594	33,110
2021-02-10	Lloyd-Smith Malcolm	Chief Regulatory Officer	Open-market sell S	Common Stock	1,100	$119.96	$131,953	32,510
2021-02-10	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M	Common Stock	1,100	$35.99	$39,589	33,610
2021-02-08	Gano Kyle	Chief Business Development Off	Equity grant / award A · derivative	Restricted Stock Unit	7,439	$0.00	$0	7,439
2021-02-08	Gano Kyle	Chief Business Development Off	Equity grant / award A · derivative	Stock Option	44,632	$0.00	$0	44,632
2021-02-08	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	1,623	$116.83	$189,622	104,768
2021-02-08	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	1,000	$116.83	$116,826	103,306
2021-02-08	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	1,070	$116.89	$125,070	102,406
2021-02-08	Lloyd-Smith Malcolm	Chief Regulatory Officer	Equity grant / award A · derivative	Stock Option	35,035	$0.00	$0	35,035
2021-02-08	ABERNETHY MATT	Chief Financial Officer	Equity grant / award A · derivative	Restricted Stock Unit	7,439	$0.00	$0	7,439
2021-02-08	ABERNETHY MATT	Chief Financial Officer	Equity grant / award A · derivative	Stock Option	44,632	$0.00	$0	44,632
2021-02-08	ABERNETHY MATT	Chief Financial Officer	Open-market sell S	Common Stock	2,030	$116.81	$237,116	14,869
2021-02-08	ABERNETHY MATT	Chief Financial Officer	Open-market sell S	Common Stock	880	$116.85	$102,826	13,043
2021-02-08	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Stock Option	49,049	$0.00	$0	49,049
2021-02-05	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	1,974	$114.09	$225,207	100,439
2021-02-05	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	703	$113.77	$79,977	98,663
2021-01-26	LYONS GARY A	Dir	Open-market sell S	Common Stock	400	$120.00	$48,000	223,697
2021-01-25	LYONS GARY A	Dir	Open-market sell S	Common Stock	1,600	$120.03	$192,047	224,097
2021-01-08	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	2,632	$111.06	$292,297	15,845
2020-12-03	SHERWIN STEPHEN A	Dir	Equity grant / award G	Common Stock	2,806	$0.00	$0	27,055
2020-12-01	ABERNETHY MATT	Chief Financial Officer	Open-market sell S	Common Stock	1,645	$94.66	$155,721	11,494
2020-11-12	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	2,257	$90.71	$204,723	17,405
2020-11-02	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	20,595	$35.99	$741,214	7,775
2020-11-02	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	20,595	$96.53	$1,987,972	15,374
2020-11-02	BENEVICH ERIC	Chief Commercial Officer	Exercise / conversion M	Common Stock	20,595	$35.99	$741,214	35,969
2020-10-02	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	987	$95.26	$94,022	9,549
2020-08-05	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	2,257	$118.84	$268,225	11,446
2020-07-09	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,657	$35.99	$59,635	36,194
2020-07-09	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	1,657	$136.02	$225,386	26,021
2020-07-09	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	1,657	$35.99	$59,635	27,678
2020-06-23	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	5,000	$77.81	$389,050	59,860
2020-06-23	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	5,000	$130.00	$650,000	9,416
2020-06-23	ROBERTS EIRY	Chief Medical Officer	Exercise / conversion M	Common Stock	5,000	$77.81	$389,050	14,416
2020-06-11	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M · derivative	Incentive Stock Option	1,049	$43.24	$45,359	2,151
2020-06-11	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M · derivative	Incentive Stock Option	1,812	$35.99	$65,214	0
2020-06-11	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M · derivative	Incentive Stock Option	2,710	$32.99	$89,403	0
2020-06-11	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M	Common Stock	1,049	$43.24	$45,359	77,563
2020-06-11	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M	Common Stock	1,812	$35.99	$65,214	76,514
2020-06-11	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M	Common Stock	2,710	$32.99	$89,403	74,702
2020-05-19	SHERWIN STEPHEN A	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option	6,018	$0.00	$0	6,018
2020-05-18	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Incentive Stock Option	5,000	$32.99	$164,950	5,000
2020-05-18	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	5,000	$120.00	$600,000	26,021
2020-05-18	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	5,000	$32.99	$164,950	31,021
2020-05-12	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	18,057	$0.00	$0	47,383
2020-05-12	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,833	$0.00	$0	13,340
2020-05-12	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	18,571	$0.00	$0	15,289
2020-05-12	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	9,094	$0.00	$0	0
2020-05-12	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	18,057	$114.94	$2,075,549	148,633
2020-05-12	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	18,057	$81.05	$1,463,520	166,690
2020-05-12	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	15,833	$114.94	$1,819,913	148,633
2020-05-12	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	15,833	$81.49	$1,290,231	164,466
2020-05-12	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	18,571	$114.94	$2,134,631	148,633
2020-05-12	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	18,571	$43.24	$803,010	167,204
2020-05-12	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	9,094	$114.94	$1,045,303	148,633
2020-05-12	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	9,094	$35.99	$327,293	157,727
2020-05-07	ABERNETHY MATT	Chief Financial Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$73.60	$1,104,000	45,000
2020-05-07	ABERNETHY MATT	Chief Financial Officer	Open-market sell S	Common Stock	15,000	$110.21	$1,653,134	5,953
2020-05-07	ABERNETHY MATT	Chief Financial Officer	Exercise / conversion M	Common Stock	15,000	$73.60	$1,104,000	20,953
2020-04-28	SHERWIN STEPHEN A	Dir	Open-market sell S	Common Stock	17,687	$99.39	$1,757,966	29,861
2020-04-24	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	1,934	$99.47	$192,376	9,416
2020-04-15	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	8,632	$94.65	$817,018	11,603
2020-02-07	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	1,623	$103.31	$167,675	7,452
2020-02-06	Gano Kyle	Chief Business Development Off	Equity grant / award A · derivative	Restricted Stock Unit	12,148	$0.00	$0	12,148
2020-02-06	Gano Kyle	Chief Business Development Off	Equity grant / award A · derivative	Stock Option	76,683	$0.00	$0	76,683
2020-02-06	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	1,000	$101.41	$101,413	90,514
2020-02-06	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Restricted Stock Unit	8,504	$0.00	$0	8,504
2020-02-06	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Stock Option	53,678	$0.00	$0	53,678
2020-02-05	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	1,974	$103.08	$203,482	89,614
2020-02-05	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	703	$103.03	$72,433	87,838
2020-02-05	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	1,013	$103.01	$104,346	87,204
2020-02-01	Sharp Shalini	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option	15,000	$0.00	$0	15,000
2020-01-08	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	2,632	$111.11	$292,445	5,991
2019-12-02	ABERNETHY MATT	Chief Financial Officer	Open-market sell S	Common Stock	1,645	$116.33	$191,360	3,876
2019-11-18	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	5,000	$35.99	$179,950	28,830
2019-11-18	Grigoriadis Dimitri E.	Chief Research Officer	Open-market sell S	Common Stock	5,000	$115.98	$579,900	108,408
2019-11-18	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M	Common Stock	5,000	$35.99	$179,950	113,408
2019-11-08	LYONS GARY A	Dir	Open-market sell S	Common Stock	5,000	$110.00	$550,000	225,697
2019-11-01	LYONS GARY A	Dir	Open-market sell S	Common Stock	5,000	$100.22	$501,104	230,697
2019-10-14	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	9,956	$15.45	$153,820	0
2019-10-14	Lloyd-Smith Malcolm	Chief Regulatory Officer	Open-market sell S	Common Stock	9,956	$90.85	$904,487	19,613
2019-10-14	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M	Common Stock	9,956	$15.45	$153,820	29,569
2019-10-02	Cooke Julie	Chief Human Resources Officer	Open-market sell S	Common Stock	987	$88.56	$87,409	3,276
2019-09-10	Norwalk Leslie V	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option	15,000	$0.00	$0	15,000
2019-09-03	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	6,736	$32.99	$222,221	6,625
2019-09-03	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	6,736	$100.00	$673,600	20,103
2019-09-03	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	6,736	$32.99	$222,221	26,839
2019-08-27	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,600	$32.99	$52,784	13,361
2019-08-27	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	1,600	$100.00	$160,000	19,961
2019-08-27	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	1,600	$32.99	$52,784	21,561
2019-08-23	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,664	$32.99	$54,895	14,961
2019-08-23	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	1,664	$100.09	$166,555	19,961
2019-08-23	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	1,664	$32.99	$54,895	21,625
2019-08-09	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M · derivative	Incentive Stock Option	3,031	$32.99	$99,993	0
2019-08-09	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M	Common Stock	3,031	$32.99	$99,993	420,628
2019-08-08	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	26,330	$8.66	$228,018	143,449
2019-08-08	GORMAN KEVIN CHARLES	Chief Executive Officer	Open-market sell S	Common Stock	26,330	$95.64	$2,518,154	417,597
2019-08-08	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M	Common Stock	26,330	$8.66	$228,018	443,927
2019-08-07	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	2,759	$8.66	$23,893	169,779
2019-08-07	GORMAN KEVIN CHARLES	Chief Executive Officer	Open-market sell S	Common Stock	2,759	$95.12	$262,440	417,597
2019-08-07	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M	Common Stock	2,759	$8.66	$23,893	420,356
2019-08-06	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	50,911	$8.66	$440,889	172,538
2019-08-06	GORMAN KEVIN CHARLES	Chief Executive Officer	Open-market sell S	Common Stock	50,911	$95.15	$4,844,380	417,597
2019-08-06	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M	Common Stock	50,911	$8.66	$440,889	468,508
2019-07-30	LYONS GARY A	Dir	Open-market sell S	Common Stock	10,000	$92.07	$920,686	235,697
2019-07-15	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	30,680	$32.99	$1,012,133	18,756
2019-07-15	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	30,680	$87.50	$2,684,506	141,976
2019-07-15	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	30,680	$32.99	$1,012,133	172,656
2019-07-11	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	100	$32.99	$3,299	49,436
2019-07-11	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	100	$87.59	$8,759	141,976
2019-07-11	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	100	$32.99	$3,299	142,076
2019-07-10	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	7,120	$32.99	$234,889	49,536
2019-07-10	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	7,120	$87.63	$623,958	141,976
2019-07-10	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	7,120	$32.99	$234,889	149,096
2019-06-18	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	2,100	$32.99	$69,279	56,656
2019-06-18	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	2,100	$87.82	$184,417	141,976
2019-06-18	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	2,100	$32.99	$69,279	144,076
2019-06-13	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,432	$32.99	$47,242	58,756
2019-06-13	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,836	$19.59	$310,227	0
2019-06-13	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	1,432	$83.29	$119,271	141,976
2019-06-13	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	1,432	$32.99	$47,242	143,408
2019-06-13	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	15,836	$82.56	$1,307,357	141,976
2019-06-13	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	15,836	$19.59	$310,227	157,812
2019-06-03	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	3,435	$19.59	$67,292	15,836
2019-06-03	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	3,435	$85.51	$293,719	141,976
2019-06-03	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	3,435	$19.59	$67,292	145,411
2019-05-31	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	19,297	$19.59	$378,028	19,271
2019-05-31	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	19,297	$85.02	$1,640,581	141,976
2019-05-31	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	19,297	$19.59	$378,028	161,273
2019-05-24	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	17,486	$19.59	$342,551	38,568
2019-05-24	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	17,486	$80.03	$1,399,434	141,976
2019-05-24	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	17,486	$19.59	$342,551	159,462
2019-05-22	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,300	$19.59	$25,467	56,054
2019-05-22	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	1,300	$80.03	$104,037	141,976
2019-05-22	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	1,300	$19.59	$25,467	143,276
2019-05-16	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	731	$19.59	$14,320	57,354
2019-05-16	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	34,376	$8.65	$297,352	0
2019-05-16	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	9,121	$5.76	$52,537	0
2019-05-16	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	22,439	$35.99	$807,580	9,094
2019-05-16	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	731	$80.13	$58,574	141,976
2019-05-16	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	731	$19.59	$14,320	142,707
2019-05-16	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	34,376	$80.13	$2,754,480	141,976
2019-05-16	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	34,376	$8.65	$297,352	176,352
2019-05-16	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	9,121	$80.13	$730,847	141,976
2019-05-16	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	9,121	$5.76	$52,537	151,097
2019-05-16	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	22,439	$80.13	$1,797,992	141,976
2019-05-16	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	22,439	$35.99	$807,580	164,415
2019-05-13	Grigoriadis Dimitri E.	Chief Research Officer	Open-market sell S	Common Stock	1,657	$75.44	$125,007	118,408
2019-03-12	NEUROCRINE BIOSCIENCES INC	10%	Open-market buy P	Common Stock	4,179,728	$11.96	$49,999,996	4,179,728
2019-02-07	Lloyd-Smith Malcolm	Chief Regulatory Officer	Equity grant / award A · derivative	Restricted Stock Unit	7,712	$0.00	$0	7,712
2019-02-07	Lloyd-Smith Malcolm	Chief Regulatory Officer	Equity grant / award A · derivative	Stock Option	41,671	$0.00	$0	41,671
2019-02-07	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Restricted Stock	12,339	$0.00	$0	12,339
2019-02-07	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Stock Option	66,673	$0.00	$0	66,673
2019-02-06	Lloyd-Smith Malcolm	Chief Regulatory Officer	Open-market sell S	Common Stock	920	$83.58	$76,894	19,238
2019-02-05	Grigoriadis Dimitri E.	Chief Research Officer	Open-market sell S	Common Stock	401	$88.17	$35,355	119,071
2019-02-05	Grigoriadis Dimitri E.	Chief Research Officer	Open-market sell S	Common Stock	669	$88.17	$58,984	118,322
2019-02-05	Lloyd-Smith Malcolm	Chief Regulatory Officer	Open-market sell S	Common Stock	603	$88.13	$53,143	17,508
2019-02-05	Lloyd-Smith Malcolm	Chief Regulatory Officer	Open-market sell S	Common Stock	669	$88.16	$58,976	16,574
2019-02-04	Grigoriadis Dimitri E.	Chief Research Officer	Open-market sell S	Common Stock	1,375	$88.12	$121,167	117,066
2019-01-08	ROBERTS EIRY	Chief Medical Officer	Open-market sell S	Common Stock	1,857	$84.09	$156,159	3,143
2018-12-03	ABERNETHY MATT	Chief Financial Officer	Open-market sell S	Common Stock	1,178	$90.00	$106,020	1,947
2018-11-26	POPS RICHARD F	Dir	Open-market sell S	Common Stock	4,124	$91.37	$376,790	29,512
2018-11-12	POPS RICHARD F	Dir	Open-market sell S	Common Stock	4,123	$103.30	$425,893	33,636
2018-11-08	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	16,794	$8.65	$145,268	34,376
2018-11-08	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	19,501	$8.66	$168,879	34,547
2018-11-08	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	16,794	$110.00	$1,847,340	135,997
2018-11-08	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	16,794	$8.65	$145,268	152,791
2018-11-08	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	19,501	$110.00	$2,145,110	135,997
2018-11-08	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	19,501	$8.66	$168,879	155,498
2018-11-07	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,046	$8.66	$130,298	54,048
2018-11-07	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	9,122	$5.76	$52,543	9,121
2018-11-07	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	5,231	$35.99	$188,264	31,533
2018-11-07	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	15,046	$110.26	$1,659,014	135,997
2018-11-07	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	15,046	$8.66	$130,298	151,043
2018-11-07	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	9,122	$110.03	$1,003,708	135,997
2018-11-07	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	9,122	$5.76	$52,543	145,119
2018-11-07	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	5,231	$110.00	$575,410	135,997
2018-11-07	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	5,231	$35.99	$188,264	141,228
2018-11-06	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	9,420	$35.99	$339,026	36,764
2018-11-06	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	9,420	$110.10	$1,037,167	135,997
2018-11-06	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	9,420	$35.99	$339,026	145,417
2018-11-02	LYONS GARY A	Dir	Open-market sell S	Common Stock	15,000	$114.41	$1,716,213	245,697
2018-10-29	POPS RICHARD F	Dir	Open-market sell S	Common Stock	5,500	$107.13	$589,237	37,759
2018-09-04	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M · derivative	Incentive Stock Option	2,102	$32.99	$69,345	2,710
2018-09-04	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M · derivative	Incentive Stock Option	5,978	$19.59	$117,109	0
2018-09-04	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M · derivative	Incentive Stock Option	11,037	$8.65	$95,470	0
2018-09-04	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M · derivative	Incentive Stock Option	13,632	$8.66	$118,053	0
2018-09-04	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M	Common Stock	2,102	$32.99	$69,345	115,691
2018-09-04	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M	Common Stock	5,978	$19.59	$117,109	113,589
2018-09-04	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M	Common Stock	11,037	$8.65	$95,470	107,611
2018-09-04	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M	Common Stock	13,632	$8.66	$118,053	96,574
2018-08-01	Gano Kyle	Chief Business Development Off	Exercise / conversion M · derivative	Non-Qualified Stock Option	28,266	$8.66	$244,784	28,266
2018-08-01	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	28,266	$115.00	$3,250,590	78,742
2018-08-01	Gano Kyle	Chief Business Development Off	Exercise / conversion M	Common Stock	28,266	$8.66	$244,784	107,008
2018-06-28	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M · derivative	Incentive Stock Option	864	$32.99	$28,503	3,031
2018-06-28	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M · derivative	Incentive Stock Option	7,142	$19.59	$139,912	0
2018-06-28	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M · derivative	Incentive Stock Option	10,199	$8.65	$88,221	0
2018-06-28	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M · derivative	Incentive Stock Option	16,551	$8.66	$143,332	0
2018-06-28	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M · derivative	Incentive Stock Option	23,168	$5.76	$133,448	0
2018-06-28	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M	Common Stock	864	$32.99	$28,503	404,957
2018-06-28	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M	Common Stock	7,142	$19.59	$139,912	404,093
2018-06-28	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M	Common Stock	10,199	$8.65	$88,221	396,951
2018-06-28	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M	Common Stock	16,551	$8.66	$143,332	386,752
2018-06-28	GORMAN KEVIN CHARLES	Chief Executive Officer	Exercise / conversion M	Common Stock	23,168	$5.76	$133,448	370,201
2018-06-20	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	23,000	$19.59	$450,570	23,022
2018-06-20	Grigoriadis Dimitri E.	Chief Research Officer	Open-market sell S	Common Stock	23,000	$105.00	$2,415,000	82,942
2018-06-20	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M	Common Stock	23,000	$19.59	$450,570	105,942
2018-06-13	LYONS GARY A	Dir	Open-market sell S	Common Stock	15,000	$99.24	$1,488,549	260,697
2018-06-11	SHERWIN STEPHEN A	Dir	Open-market sell S	Common Stock	10,000	$98.44	$984,420	47,548
2018-06-01	BENEVICH ERIC	Chief Commercial Officer	Open-market sell S	Common Stock	12,350	$97.34	$1,202,164	16,690
2018-05-24	SHERWIN STEPHEN A	Dir	Equity grant / award A · derivative	Non-Qualified Stock Option	12,500	$0.00	$0	12,500
2018-05-07	Nevinny Corinne H	Dir	Open-market sell S	Common Stock	5,000	$83.12	$415,625	43,283
2018-05-02	Nevinny Corinne H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$7.05	$105,750	0
2018-05-02	Nevinny Corinne H	Dir	Other disposed transaction F	Common Stock	1,320	$80.08	$105,706	48,283
2018-05-02	Nevinny Corinne H	Dir	Exercise / conversion M	Common Stock	15,000	$7.05	$105,750	49,603
2018-05-01	POPS RICHARD F	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$7.05	$105,750	0
2018-05-01	POPS RICHARD F	Dir	Other disposed transaction F	Common Stock	1,253	$84.39	$105,741	43,259
2018-05-01	POPS RICHARD F	Dir	Exercise / conversion M	Common Stock	15,000	$7.05	$105,750	44,512
2018-04-26	SHERWIN STEPHEN A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$7.05	$105,750	0
2018-04-26	SHERWIN STEPHEN A	Dir	Other disposed transaction F	Common Stock	1,331	$79.44	$105,735	57,548
2018-04-26	SHERWIN STEPHEN A	Dir	Exercise / conversion M	Common Stock	15,000	$7.05	$105,750	58,879
2018-04-03	LYONS GARY A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$7.05	$105,750	0
2018-04-03	LYONS GARY A	Dir	Other disposed transaction F	Common Stock	1,369	$77.23	$105,728	275,697
2018-04-03	LYONS GARY A	Dir	Exercise / conversion M	Common Stock	15,000	$7.05	$105,750	277,066
2018-03-05	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,979	$18.15	$35,919	15,831
2018-03-05	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	1,979	$88.47	$175,090	16,062
2018-03-05	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	1,979	$18.15	$35,919	18,041
2018-02-15	LYONS GARY A	Dir	Open-market sell S	Common Stock	5,000	$84.67	$423,341	262,066
2018-02-12	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	14,593	$8.66	$126,375	0
2018-02-12	Grigoriadis Dimitri E.	Chief Research Officer	Open-market sell S	Common Stock	14,593	$80.00	$1,167,453	82,942
2018-02-12	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M	Common Stock	14,593	$8.66	$126,375	97,535
2018-02-09	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	71,775	$8.66	$621,572	14,593
2018-02-09	Grigoriadis Dimitri E.	Chief Research Officer	Open-market sell S	Common Stock	71,775	$77.98	$5,596,720	82,942
2018-02-09	Grigoriadis Dimitri E.	Chief Research Officer	Exercise / conversion M	Common Stock	71,775	$8.66	$621,572	154,717
2018-02-05	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Restricted Stock Unit	18,400	$0.00	$0	18,400
2018-02-05	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Restricted Stock Unit	12,250	$0.00	$0	12,250
2018-01-24	RASTETTER WILLIAM H	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	20,000	$7.05	$141,000	0
2018-01-24	RASTETTER WILLIAM H	Dir	Open-market sell S	Common Stock	9,500	$90.00	$855,000	24,750
2018-01-24	RASTETTER WILLIAM H	Dir	Exercise / conversion M	Common Stock	20,000	$7.05	$141,000	34,250
2018-01-16	OBrien Christopher Flint	Chief Medical Officer	Open-market sell S	Common Stock	1,750	$79.14	$138,499	50,723
2018-01-08	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Restricted Stock Units	20,000	$0.00	$0	20,000
2018-01-08	ROBERTS EIRY	Chief Medical Officer	Equity grant / award A · derivative	Non-Qualified Stock Option	70,000	$0.00	$0	70,000
2018-01-03	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	1,979	$18.15	$35,919	19,789
2018-01-03	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	1,979	$79.36	$157,053	13,157
2018-01-03	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	1,979	$18.15	$35,919	15,136
2018-01-02	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	18,084	$15.45	$279,398	18,956
2018-01-02	Lloyd-Smith Malcolm	Chief Regulatory Officer	Open-market sell S	Common Stock	18,084	$77.52	$1,401,823	13,017
2018-01-02	Lloyd-Smith Malcolm	Chief Regulatory Officer	Exercise / conversion M	Common Stock	18,084	$15.45	$279,398	31,101
2017-12-28	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,237	$18.15	$276,552	21,768
2017-12-28	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	15,237	$75.00	$1,142,775	13,157
2017-12-28	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	15,237	$18.15	$276,552	28,394
2017-12-08	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	2,955	$18.15	$53,633	37,005
2017-12-08	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	2,955	$75.00	$221,625	13,157
2017-12-08	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	2,955	$18.15	$53,633	16,112
2017-12-04	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	6,279	$18.15	$113,964	39,960
2017-12-04	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	6,279	$75.04	$471,160	13,157
2017-12-04	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	6,279	$18.15	$113,964	19,436
2017-12-01	LYONS GARY A	Dir	Open-market sell S	Common Stock	10,000	$72.92	$729,182	272,066
2017-11-15	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-qualified Stock Option	9,900	$18.15	$179,685	22,492
2017-11-15	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	9,900	$73.05	$723,191	13,157
2017-11-15	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	9,900	$18.15	$179,685	23,057
2017-11-08	Grigoriadis Dimitri E.	Chief Research Officer	Open-market sell S	Common Stock	30,000	$74.58	$2,237,343	77,691
2017-11-02	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M · derivative	Non Qualified Stock Option	7,518	$8.65	$65,031	62,823
2017-11-02	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M · derivative	Incentive Stock Option	14,049	$8.66	$121,664	0
2017-11-02	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M · derivative	Non Qualified Stock Option	31,250	$8.66	$270,625	14,049
2017-11-02	OBrien Christopher Flint	Chief Medical Officer	Open-market sell S	Common Stock	7,518	$69.71	$524,047	48,973
2017-11-02	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M	Common Stock	7,518	$8.65	$65,031	56,491
2017-11-02	OBrien Christopher Flint	Chief Medical Officer	Open-market sell S	Common Stock	45,299	$69.71	$3,157,594	48,973
2017-11-02	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M	Common Stock	45,299	$8.66	$392,289	94,272
2017-10-02	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	6,925	$8.65	$59,901	70,341
2017-10-02	OBrien Christopher Flint	Chief Medical Officer	Open-market sell S	Common Stock	6,925	$61.04	$422,702	48,973
2017-10-02	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M	Common Stock	6,925	$8.65	$59,901	55,898
2017-09-06	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	100	$18.15	$1,815	56,139
2017-09-06	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	100	$60.00	$6,000	13,157
2017-09-06	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	100	$18.15	$1,815	13,257
2017-09-06	Gano Kyle	Chief Business Development Off	Exercise / conversion M · derivative	Stock Option	20,393	$8.65	$176,399	35,000
2017-09-06	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	20,393	$60.00	$1,223,580	73,246
2017-09-06	Gano Kyle	Chief Business Development Off	Exercise / conversion M	Common Stock	20,393	$8.65	$176,399	93,639
2017-09-05	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	52,817	$8.66	$457,395	45,299
2017-09-05	OBrien Christopher Flint	Chief Medical Officer	Open-market sell S	Common Stock	52,817	$57.50	$3,036,978	48,973
2017-09-05	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M	Common Stock	52,817	$8.66	$457,395	101,790
2017-08-09	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	5,000	$18.15	$90,750	56,239
2017-08-09	Lippoldt Darin	Chief Legal Officer	Open-market sell S	Common Stock	5,000	$55.00	$275,000	13,157
2017-08-09	Lippoldt Darin	Chief Legal Officer	Exercise / conversion M	Common Stock	5,000	$18.15	$90,750	18,157
2017-08-04	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Incentive Stock Option	2,726	$8.66	$23,607	80,000
2017-08-04	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non Qualified Stock Option	17,274	$8.66	$149,593	82,726
2017-08-04	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Incentive Stock Option	5,071	$5.76	$29,209	100,000
2017-08-04	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M · derivative	Non Qualified Stock Option	19,929	$5.76	$114,791	105,071
2017-08-04	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	20,000	$50.00	$1,000,000	129,601
2017-08-04	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	20,000	$8.66	$173,200	149,601
2017-08-04	Bozigian Haig P.	Chief Development Officer	Open-market sell S	Common Stock	2,500	$50.00	$125,000	129,601
2017-08-04	Bozigian Haig P.	Chief Development Officer	Exercise / conversion M	Common Stock	25,000	$5.76	$144,000	154,601
2017-07-27	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	8,734	$8.65	$75,549	77,266
2017-07-27	OBrien Christopher Flint	Chief Medical Officer	Open-market sell S	Common Stock	8,734	$50.00	$436,700	48,973
2017-07-27	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M	Common Stock	8,734	$8.65	$75,549	57,707
2017-05-23	Grigoriadis Dimitri E.	Chief Research Officer	Open-market sell S	Common Stock	10,000	$53.39	$533,900	107,691
2017-05-22	SHERWIN STEPHEN A	Dir	Equity grant / award A · derivative	Stock Option	15,000	$0.00	$0	15,000
2017-05-18	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	21,884	$8.66	$189,515	98,116
2017-05-18	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M · derivative	Incentive Stock Option	24,105	$5.76	$138,845	0
2017-05-18	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M · derivative	Non-Qualified Stock Option	59,645	$5.76	$343,555	24,105
2017-05-18	OBrien Christopher Flint	Chief Medical Officer	Open-market sell S	Common Stock	105,634	$53.32	$5,632,405	48,973
2017-05-18	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M	Common Stock	21,884	$8.66	$189,515	154,607
2017-05-18	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M	Common Stock	24,105	$5.76	$138,845	132,723
2017-05-18	OBrien Christopher Flint	Chief Medical Officer	Exercise / conversion M	Common Stock	59,645	$5.76	$343,555	108,618
2017-05-05	Nevinny Corinne H	Dir	Open-market sell S	Common Stock	5,000	$53.98	$269,900	34,603
2017-05-03	POPS RICHARD F	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$0.00	$0	0
2017-05-03	POPS RICHARD F	Dir	Other disposed transaction F	Common Stock	952	$53.37	$50,808	29,512
2017-05-03	POPS RICHARD F	Dir	Exercise / conversion M	Common Stock	15,000	$3.40	$51,000	30,454
2017-05-02	Grigoriadis Dimitri E.	Chief Research Officer	Open-market sell S	Common Stock	10,000	$55.00	$550,000	117,691
2017-05-01	Gano Kyle	Chief Business Development Off	Exercise / conversion M · derivative	Employee Stock Option (right to buy)	15,000	$2.59	$38,850	0
2017-05-01	Gano Kyle	Chief Business Development Off	Open-market sell S	Common Stock	15,000	$54.00	$810,000	73,246
2017-05-01	Gano Kyle	Chief Business Development Off	Exercise / conversion M	Common Stock	15,000	$2.59	$38,850	88,246
2017-04-12	MOLLICA JOSEPH A	Dir	Exercise / conversion M · derivative	Stock Option	20,000	$0.00	$0	0
2017-04-12	MOLLICA JOSEPH A	Dir	Other disposed transaction F	Common Stock	1,312	$51.80	$67,962	56,042
2017-04-12	MOLLICA JOSEPH A	Dir	Exercise / conversion M	Common Stock	20,000	$3.40	$68,000	57,354
2017-02-14	LYONS GARY A	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Option	15,000	$0.00	$0	0
2017-02-14	LYONS GARY A	Dir	Exercise / conversion M	Common Stock	15,000	$3.40	$51,000	282,066

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count