Financial Metrics

NVAX NOVAVAX INC

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2020-06-30	-0.3	—	USD/shares	10-Q	2021-08-05
Quarterly	2020-09-30	-3.21	-970.0%	USD/shares	10-Q	2021-11-05
Quarterly	2021-03-31	-3.05	+5.0%	USD/shares	10-Q	2022-05-10
Quarterly	2021-06-30	-4.75	-55.7%	USD/shares	10-Q	2021-08-05
Quarterly	2021-09-30	-4.31	+9.3%	USD/shares	10-Q	2021-11-05
Quarterly	2022-03-31	2.56	+159.4%	USD/shares	10-Q	2023-05-09
Quarterly	2022-06-30	-6.53	-355.1%	USD/shares	10-Q	2023-08-08
Quarterly	2022-09-30	-2.15	+67.1%	USD/shares	10-Q	2023-11-09
Quarterly	2023-03-31	-3.41	-58.6%	USD/shares	10-Q	2024-05-10
Quarterly	2023-06-30	0.58	+117.0%	USD/shares	10-Q	2024-08-08
Quarterly	2023-09-30	-1.26	-317.2%	USD/shares	10-Q	2024-11-12
Quarterly	2024-03-31	-1.05	+16.7%	USD/shares	10-Q	2025-05-08
Quarterly	2024-06-30	0.99	+194.3%	USD/shares	10-Q	2025-08-06
Quarterly	2024-09-30	-0.76	-176.8%	USD/shares	10-Q	2025-11-06
Quarterly	2025-03-31	2.93	+485.5%	USD/shares	10-Q	2025-05-08
Quarterly	2025-06-30	0.62	-78.8%	USD/shares	10-Q	2025-08-06
Quarterly	2025-09-30	-1.25	-301.6%	USD/shares	10-Q	2025-11-06
Annual	2019-12-31	-5.51	—	USD/shares	10-K	2022-03-01
Annual	2020-12-31	-7.27	-31.9%	USD/shares	10-K	2023-02-28
Annual	2021-12-31	-23.44	-222.4%	USD/shares	10-K	2024-02-28
Annual	2022-12-31	-8.42	+64.1%	USD/shares	10-K	2025-02-27
Annual	2023-12-31	-5.41	+35.7%	USD/shares	10-K	2026-02-26
Annual	2024-12-31	-1.23	+77.3%	USD/shares	10-K	2026-02-26
Annual	2025-12-31	2.58	+309.8%	USD/shares	10-K	2026-02-26

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2021-09-30	41122000.0	—	USD	10-Q	2022-11-09
Quarterly	2022-09-30	66033000.0	+60.6%	USD	10-Q	2022-11-09

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	270179.0	—	shares	10-Q	2017-05-08
Quarterly	2016-06-30	270760.0	+0.2%	shares	10-Q	2017-08-08
Quarterly	2016-09-30	271064.0	+0.1%	shares	10-Q	2017-11-07
Quarterly	2017-03-31	274178.0	+1.1%	shares	10-Q	2018-05-09
Quarterly	2017-06-30	283444000.0	+103279.6%	shares	10-Q	2018-08-08
Quarterly	2017-09-30	296435000.0	+4.6%	shares	10-Q	2018-11-07
Quarterly	2018-03-31	336972000.0	+13.7%	shares	10-Q	2019-05-02
Quarterly	2018-06-30	18796000.0	-94.4%	shares	10-Q	2019-08-07
Quarterly	2018-09-30	19116000.0	+1.7%	shares	10-Q	2019-11-07
Quarterly	2019-03-31	20442000.0	+6.9%	shares	10-Q	2020-05-11
Quarterly	2019-06-30	23473000.0	+14.8%	shares	10-Q	2020-08-10
Quarterly	2019-09-30	24327000.0	+3.6%	shares	10-Q	2020-11-10
Quarterly	2020-03-31	44421000.0	+82.6%	shares	10-Q	2021-05-10
Quarterly	2020-06-30	58618000.0	+32.0%	shares	10-Q	2021-08-05
Quarterly	2020-09-30	61554000.0	+5.0%	shares	10-Q	2021-11-05
Quarterly	2021-03-31	73035000.0	+18.7%	shares	10-Q	2022-05-10
Quarterly	2021-06-30	74118000.0	+1.5%	shares	10-Q	2021-08-05
Quarterly	2021-09-30	74745000.0	+0.8%	shares	10-Q	2021-11-05
Quarterly	2022-03-31	80711000.0	+8.0%	shares	10-Q	2023-05-09
Quarterly	2022-06-30	78143000.0	-3.2%	shares	10-Q	2023-08-08
Quarterly	2022-09-30	78274000.0	+0.2%	shares	10-Q	2023-11-09
Quarterly	2023-03-31	86158000.0	+10.1%	shares	10-Q	2024-05-10
Quarterly	2023-06-30	104065000.0	+20.8%	shares	10-Q	2024-08-08
Quarterly	2023-09-30	103429000.0	-0.6%	shares	10-Q	2024-11-12
Quarterly	2024-03-31	139916000.0	+35.3%	shares	10-Q	2025-05-08
Quarterly	2024-06-30	165855000.0	+18.5%	shares	10-Q	2025-08-06
Quarterly	2024-09-30	160049000.0	-3.5%	shares	10-Q	2025-11-06
Quarterly	2025-03-31	177625000.0	+11.0%	shares	10-Q	2025-05-08
Quarterly	2025-06-30	177215000.0	-0.2%	shares	10-Q	2025-08-06
Quarterly	2025-09-30	162353000.0	-8.4%	shares	10-Q	2025-11-06
Annual	2016-12-31	270802000.0	—	shares	10-K	2019-03-18
Annual	2017-12-31	14633000.0	-94.6%	shares	10-K	2020-03-11
Annual	2018-12-31	18488000.0	+26.3%	shares	10-K	2021-03-01
Annual	2019-12-31	24100000.0	+30.4%	shares	10-K	2022-03-01
Annual	2020-12-31	57554000.0	+138.8%	shares	10-K	2023-02-28
Annual	2021-12-31	74400000.0	+29.3%	shares	10-K	2024-02-28
Annual	2022-12-31	78183000.0	+5.1%	shares	10-K	2025-02-27
Annual	2023-12-31	100768000.0	+28.9%	shares	10-K	2026-02-26
Annual	2024-12-31	152190000.0	+51.0%	shares	10-K	2026-02-26
Annual	2025-12-31	173103000.0	+13.7%	shares	10-K	2026-02-26

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

N/A

Total Liabilities (latest annual)

1,304,265,000

Current Liabilities (latest annual)

459,950,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-0.4166	—	ratio	10-Q	2017-05-08
Quarterly	2016-06-30	-0.7206	-73.0%	ratio	10-Q	2017-08-08
Quarterly	2016-09-30	-1.3308	-84.7%	ratio	10-Q	2017-11-07
Quarterly	2017-03-31	1.5071	+213.2%	ratio	10-Q	2018-05-09
Quarterly	2017-06-30	0.7529	-50.0%	ratio	10-Q	2018-08-08
Quarterly	2017-09-30	0.6016	-20.1%	ratio	10-Q	2018-11-07
Quarterly	2018-03-31	0.4665	-22.5%	ratio	10-Q	2019-05-02
Quarterly	2018-06-30	1.0358	+122.0%	ratio	10-Q	2019-08-07
Quarterly	2018-09-30	0.3518	-66.0%	ratio	10-Q	2019-11-07
Quarterly	2019-03-31	0.2870	-18.4%	ratio	10-Q	2020-05-11
Quarterly	2019-06-30	0.2135	-25.6%	ratio	10-Q	2020-08-10
Quarterly	2019-09-30	0.0950	-55.5%	ratio	10-Q	2020-11-10
Quarterly	2020-03-31	1.0790	+1035.2%	ratio	10-Q	2021-05-10
Quarterly	2020-06-30	-0.0950	-108.8%	ratio	10-Q	2021-08-05
Quarterly	2020-09-30	-1.8537	-1852.3%	ratio	10-Q	2021-11-05
Quarterly	2021-03-31	-0.2143	+88.4%	ratio	10-Q	2022-05-10
Quarterly	2021-06-30	-0.4726	-120.5%	ratio	10-Q	2022-08-09
Quarterly	2021-09-30	-0.6989	-47.9%	ratio	10-Q	2022-11-09
Quarterly	2022-03-31	3.1138	+545.5%	ratio	10-Q	2023-05-09
Quarterly	2022-06-30	1.2243	-60.7%	ratio	10-Q	2023-08-08
Quarterly	2022-09-30	0.2979	-75.7%	ratio	10-Q	2023-11-09
Quarterly	2023-03-31	0.3282	+10.2%	ratio	10-Q	2024-05-10
Quarterly	2023-06-30	-0.0769	-123.4%	ratio	10-Q	2024-08-08
Quarterly	2023-09-30	0.1928	+350.8%	ratio	10-Q	2024-11-12
Quarterly	2024-03-31	0.1702	-11.7%	ratio	10-Q	2025-05-08
Quarterly	2024-06-30	-0.3761	-321.0%	ratio	10-Q	2025-08-06
Quarterly	2024-09-30	0.2304	+161.3%	ratio	10-Q	2025-11-06
Quarterly	2025-03-31	-6.8565	-3075.7%	ratio	10-Q	2025-05-08
Quarterly	2025-06-30	2.8308	+141.3%	ratio	10-Q	2025-08-06
Quarterly	2025-09-30	1.2917	-54.4%	ratio	10-Q	2025-11-06
Annual	2016-12-31	50.4807	—	ratio	10-K	2019-03-18
Annual	2017-12-31	1.8064	-96.4%	ratio	10-K	2020-03-11
Annual	2018-12-31	1.1001	-39.1%	ratio	10-K	2021-03-01
Annual	2019-12-31	0.7133	-35.2%	ratio	10-K	2022-03-01
Annual	2020-12-31	-0.6669	-193.5%	ratio	10-K	2023-02-28
Annual	2021-12-31	4.9584	+843.6%	ratio	10-K	2024-02-28
Annual	2022-12-31	1.0376	-79.1%	ratio	10-K	2025-02-27
Annual	2023-12-31	0.7603	-26.7%	ratio	10-K	2026-02-26
Annual	2024-12-31	0.3006	-60.5%	ratio	10-K	2026-02-26
Annual	2025-12-31	-3.4465	-1246.7%	ratio	10-K	2026-02-26

8-K Material Event Details

94 filings · 183 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

1127 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-03-10	Shiver John W.	Dir	Exercise / conversion M · derivative	Restricted Stock Units	7,947	$0.00	$0	15,893
2026-03-10	Shiver John W.	Dir	Exercise / conversion M	Common Stock	7,947	$0.00	$0	7,947
2026-03-07	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M · derivative	Restricted Stock Units	12,223	$0.00	$0	0
2026-03-07	Kelly James Patrick	EVP, CFO and Treasurer	Other disposed transaction F	Common Stock	5,904	$9.98	$58,922	130,599
2026-03-07	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M	Common Stock	12,223	$0.00	$0	136,503
2026-03-03	Draghia-Akli Ruxandra	EVP, Research & Development	Other disposed transaction D · derivative	Restricted Stock Units	26,667	$0.00	$0	53,333
2026-03-03	Draghia-Akli Ruxandra	EVP, Research & Development	Other disposed transaction F	Common Stock	11,313	$9.49	$107,360	23,563
2026-03-03	Draghia-Akli Ruxandra	EVP, Research & Development	Exercise / conversion M	Common Stock	26,667	$0.00	$0	34,876
2026-03-03	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M · derivative	Restricted Stock Units	43,167	$0.00	$0	86,333
2026-03-03	Kelly James Patrick	EVP, CFO and Treasurer	Other disposed transaction F	Common Stock	20,850	$9.49	$197,866	124,280
2026-03-03	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M	Common Stock	43,167	$0.00	$0	145,130
2026-03-02	Jacobs John C	President and CEO	Equity grant / award A · derivative	Non-Statutory Stock Option NQ	551,500	$9.09	$5,013,135	551,500
2026-03-02	Jacobs John C	President and CEO	Equity grant / award A · derivative	Restricted Stock Units	367,500	$0.00	$0	367,500
2026-03-02	Draghia-Akli Ruxandra	EVP, Research & Development	Equity grant / award A · derivative	Non-Statutory Stock Opotion NQ	139,500	$9.09	$1,268,055	139,500
2026-03-02	Draghia-Akli Ruxandra	EVP, Research & Development	Equity grant / award A · derivative	Restricted Stock Units	93,000	$0.00	$0	101,000
2026-03-02	Kelly James Patrick	EVP, CFO and Treasurer	Equity grant / award A · derivative	Non-statutory Stock Option NQ	194,000	$0.00	$0	194,000
2026-03-01	Jacobs John C	President and CEO	Exercise / conversion M · derivative	Restricted Stock Units	83,333	$0.00	$0	0
2026-03-01	Jacobs John C	President and CEO	Other disposed transaction F	Common Stock	38,450	$10.14	$389,883	225,680
2026-03-01	Jacobs John C	President and CEO	Exercise / conversion M	Common Stock	83,333	$0.00	$0	264,130
2026-01-23	Jacobs John C	President and CEO	Exercise / conversion M · derivative	Restricted Stock Units	83,197	$0.00	$0	0
2026-01-23	Jacobs John C	President and CEO	Other disposed transaction F	Common Stock	39,132	$9.17	$358,840	180,797
2026-01-23	Jacobs John C	President and CEO	Exercise / conversion M	Common Stock	83,197	$0.00	$0	219,929
2025-12-11	Casey Mark J	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Restricted Stock Units	41,899	$0.00	$0	41,899
2025-12-11	Casey Mark J	EVP, Chief Legal Officer	Other disposed transaction F	Common Stock	12,713	$6.69	$85,050	61,159
2025-12-11	Casey Mark J	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	41,899	$0.00	$0	73,972
2025-11-11	Draghia-Akli Ruxandra	Section 16	Other disposed transaction D · derivative	Restricted Stock Units	14,257	$0.00	$0	28,513
2025-11-11	Draghia-Akli Ruxandra	Section 16	Other disposed transaction F	Common Stock	6,048	$7.40	$44,755	8,209
2025-11-11	Draghia-Akli Ruxandra	Section 16	Exercise / conversion M	Common Stock	14,257	$0.00	$0	14,257
2025-10-29	Rodgers Richard J	Dir	Exercise / conversion M · derivative	Restricted Stock Units	3,800	$0.00	$0	0
2025-10-29	Rodgers Richard J	Dir	Exercise / conversion M	Common Stock	3,800	—	—	28,490
2025-06-20	Rodgers Richard J	Dir	Equity grant / award A · derivative	Restricted Stock Units	18,884	$0.00	$0	18,884
2025-06-20	Rodgers Richard J	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	28,326	$6.42	$181,853	28,326
2025-06-12	MCGLYNN MARGARET G	—	Exercise / conversion M · derivative	Restricted Stock Units	10,420	$0.00	$0	0
2025-06-12	MCGLYNN MARGARET G	—	Exercise / conversion M	Common Stock	10,420	$0.00	$0	25,588
2025-04-25	Newton Charles W.	Dir	Equity grant / award A · derivative	Restricted Stock Units	28,560	$0.00	$0	28,560
2025-04-25	Newton Charles W.	Dir	Equity grant / award A · derivative	Stock Option (Right to buy)	42,840	$0.00	$0	42,840
2025-03-10	Shiver John W.	Dir	Equity grant / award A · derivative	Restricted Stock Units	23,840	$0.00	$0	23,840
2025-03-10	Shiver John W.	Dir	Equity grant / award A · derivative	Stock Option (Right to buy)	35,770	$0.00	$0	35,770
2025-03-07	Trizzino John	President and COO	Exercise / conversion M · derivative	Restricted Stock Units	28,890	$0.00	$0	28,890
2025-03-07	Trizzino John	President and COO	Other disposed transaction F	Common Stock	13,954	$8.34	$116,376	68,061
2025-03-07	Trizzino John	President and COO	Exercise / conversion M	Common Stock	28,890	$0.00	$0	82,015
2025-03-03	Casey Mark J	EVP, Chief Legal Officer	Equity grant / award A · derivative	2025 Restricted Stock Units RSU	112,500	$0.00	$0	112,500
2025-03-03	Casey Mark J	EVP, Chief Legal Officer	Equity grant / award A · derivative	2025 Non-statutory Stock Option NQ	169,000	$7.87	$1,330,030	169,000
2025-03-01	Trizzino John	President and COO	Exercise / conversion M · derivative	Restricted Stock Units	48,000	$0.00	$0	96,000
2025-03-01	Trizzino John	President and COO	Other disposed transaction F	Common Stock	23,185	$8.33	$193,131	53,125
2025-03-01	Trizzino John	President and COO	Exercise / conversion M	Common Stock	48,000	$0.00	$0	76,310
2025-01-23	Jacobs John C	President and CEO	Exercise / conversion M · derivative	Restricted Stock Units	83,196	$0.00	$0	83,197
2025-01-23	Jacobs John C	President and CEO	Other disposed transaction F	Common Stock	38,873	$9.55	$371,237	91,849
2025-01-23	Jacobs John C	President and CEO	Exercise / conversion M	Common Stock	83,196	$0.00	$0	130,722
2024-12-31	Alton Gregg H	Dir	Equity grant / award A	Common Stock	1,982	$8.61	$17,065	18,385
2024-12-31	YOUNG JAMES F	—	Open-market sell S	Common Stock	5,400	$8.00	$43,200	51,760
2024-12-31	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M · derivative	Restricted Stock Units	35,000	$0.00	$0	0
2024-12-31	Kelly James Patrick	EVP, CFO and Treasurer	Other disposed transaction F	Common Stock	16,906	$8.04	$135,924	32,602
2024-12-31	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M	Common Stock	35,000	$0.00	$0	49,508
2024-12-24	YOUNG JAMES F	—	Open-market sell S	Common Stock	4,600	$8.48	$39,008	57,160
2024-12-13	King Rachel K.	—	Open-market sell S	Common Stock	4,150	$9.02	$37,435	14,770
2024-12-11	Casey Mark J	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Restricted Stock Units	41,900	$0.00	$0	83,798
2024-12-11	Casey Mark J	EVP, Chief Legal Officer	Other disposed transaction F	Common Stock	12,713	$8.82	$112,129	29,187
2024-12-11	Casey Mark J	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	41,900	$0.00	$0	41,900
2024-11-11	Draghia-Akli Ruxandra	Section 16	Equity grant / award A · derivative	Restricted Stock Units	42,770	$0.00	$0	42,770
2024-11-11	Draghia-Akli Ruxandra	Section 16	Equity grant / award A · derivative	Stock Option (Right to Buy)	64,150	$9.01	$577,992	64,150
2024-10-29	Rodgers Richard J	—	Exercise / conversion M · derivative	Restricted Stock Units	3,800	$0.00	$0	3,800
2024-10-29	Rodgers Richard J	—	Exercise / conversion M	Common Stock	3,800	$0.00	$0	14,270
2024-09-30	Alton Gregg H	Dir	Equity grant / award A	Common Stock	1,311	$12.77	$16,741	16,403
2024-08-19	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Restricted Stock Units	655	$0.00	$0	0
2024-08-19	Trizzino John	EVP, CCO and CBO	Other disposed transaction F	Common Stock	317	$13.90	$4,406	28,310
2024-08-19	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	655	$0.00	$0	28,627
2024-08-16	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M · derivative	Restricted Stock Units	2,367	$0.00	$0	0
2024-08-16	Kelly James Patrick	EVP, CFO and Treasurer	Other disposed transaction F	Common Stock	1,223	$12.96	$15,850	14,429
2024-08-16	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M	Common Stock	2,367	$12.96	$30,676	15,652
2024-06-30	Alton Gregg H	Dir	Equity grant / award A	Common Stock	1,202	$13.93	$16,744	15,092
2024-06-21	YOUNG JAMES F	—	Open-market sell S	Common Stock	7,500	$14.09	$105,675	61,760
2024-06-18	YOUNG JAMES F	—	Open-market sell S	Common Stock	1,107	$14.28	$15,808	69,260
2024-06-18	YOUNG JAMES F	—	Open-market sell S	Common Stock	6,393	$13.62	$87,073	70,367
2024-06-17	Dubovsky Filip	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	12,500	$6.09	$76,125	37,500
2024-06-17	Dubovsky Filip	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,404	$6.97	$9,786	46,324
2024-06-17	Dubovsky Filip	President, R&D	Open-market sell S	Common Stock	1,404	$14.54	$20,414	66,613
2024-06-17	Dubovsky Filip	President, R&D	Open-market sell S	Common Stock	12,500	$14.46	$180,750	68,017
2024-06-17	Dubovsky Filip	President, R&D	Exercise / conversion M	Common Stock	12,500	$6.09	$76,125	80,517
2024-06-17	Dubovsky Filip	President, R&D	Exercise / conversion M	Common Stock	1,404	$6.97	$9,786	68,017
2024-06-12	MCGLYNN MARGARET G	—	Equity grant / award A · derivative	Restricted Stock Units	10,420	$0.00	$0	10,420
2024-06-12	MCGLYNN MARGARET G	—	Equity grant / award A · derivative	Stock Option (Right to Buy)	15,630	$15.86	$247,892	15,630
2024-06-12	MCGLYNN MARGARET G	—	Exercise / conversion M · derivative	Restricted Stock Units	6,670	$0.00	$0	0
2024-06-12	MCGLYNN MARGARET G	—	Exercise / conversion M	Common Stock	6,670	$0.00	$0	10,470
2024-05-14	Dubovsky Filip	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	19,652	$0.00	$0	47,728
2024-05-14	Dubovsky Filip	President, R&D	Open-market sell S	Common Stock	47,312	$13.90	$657,637	38,953
2024-05-14	Dubovsky Filip	President, R&D	Exercise / conversion M	Common Stock	19,652	$6.97	$136,974	86,265
2024-03-31	Alton Gregg H	Dir	Equity grant / award A	Common Stock	3,420	$4.90	$16,758	7,220
2024-03-10	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M · derivative	Restricted Stock Units	4,608	$0.00	$0	4,608
2024-03-10	Kelly James Patrick	EVP, CFO and Treasurer	Other disposed transaction F	Common Stock	2,226	$5.45	$12,132	13,285
2024-03-10	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M	Common Stock	4,608	—	—	15,511
2024-03-07	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M · derivative	Restricted Stock Units	12,224	$0.00	$0	24,446
2024-03-07	Kelly James Patrick	EVP, CFO and Treasurer	Other disposed transaction F	Common Stock	5,905	$5.61	$33,127	10,903
2024-03-07	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M	Common Stock	12,224	—	—	16,808
2024-03-07	Dubovsky Filip	President, R&D	Exercise / conversion M · derivative	Restricted Stock Units	19,444	$0.00	$0	0
2024-03-07	Dubovsky Filip	President, R&D	Other disposed transaction F	Common Stock	9,392	$5.61	$52,689	63,834
2024-03-07	Dubovsky Filip	President, R&D	Exercise / conversion M	Common Stock	19,444	—	—	73,226
2024-03-01	Trizzino John	EVP, CCO and CBO	Equity grant / award A · derivative	Restricted Stock Units	144,000	$0.00	$0	144,000
2024-01-23	Jacobs John C	President and CEO	Exercise / conversion M · derivative	Restricted Stock Units	83,197	$0.00	$0	166,393
2024-01-23	Jacobs John C	President and CEO	Other disposed transaction F	Common Stock	40,093	$4.26	$170,796	43,104
2024-01-23	Jacobs John C	President and CEO	Exercise / conversion M	Common Stock	83,197	—	—	83,197
2023-12-14	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Restricted Stock Units	1,600	$0.00	$0	0
2023-12-14	Trizzino John	EVP, CCO and CBO	Other disposed transaction F	Common Stock	773	$5.69	$4,398	10,655
2023-12-14	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	1,600	—	—	11,428
2023-12-11	Casey Mark J	EVP, Chief Legal Officer	Equity grant / award A · derivative	Restricted Stock Units	125,698	$0.00	$0	125,698
2023-12-11	Casey Mark J	EVP, Chief Legal Officer	Equity grant / award A · derivative	Stock Options (Right to buy)	144,694	$0.00	$0	144,694
2023-11-05	Dubovsky Filip	President, R&D	Exercise / conversion M · derivative	Restricted Stock Units	1,400	$0.00	$0	0
2023-11-05	Dubovsky Filip	President, R&D	Other disposed transaction F	Common Stock	677	$7.06	$4,780	52,317
2023-11-05	Dubovsky Filip	President, R&D	Exercise / conversion M	Common Stock	1,400	$7.06	$9,884	52,994
2023-10-29	Rodgers Richard J	Dir	Exercise / conversion M · derivative	Restricted Stock Units	3,800	$0.00	$0	7,600
2023-10-29	Rodgers Richard J	Dir	Exercise / conversion M	Common Stock	3,800	—	—	3,800
2023-09-16	Dubovsky Filip	President, R&D	Exercise / conversion M · derivative	Restricted Stock Units	12,644	$0.00	$0	0
2023-09-16	Dubovsky Filip	President, R&D	Other disposed transaction F	Common Stock	6,108	$7.71	$47,093	51,594
2023-09-16	Dubovsky Filip	President, R&D	Exercise / conversion M	Common Stock	12,644	$7.71	$97,485	57,702
2023-09-12	Kelly James Patrick	EVP, CFO and Treasurer	Equity grant / award A · derivative	Restricted Stock Units	35,000	$0.00	$0	35,000
2023-08-19	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Restricted Stock Units	655	$0.00	$0	655
2023-08-19	Trizzino John	EVP, CCO and CBO	Other disposed transaction F	Common Stock	317	$7.14	$2,263	9,828
2023-08-19	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	655	—	—	10,145
2023-08-16	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M · derivative	Restricted Stock Units	2,366	$0.00	$0	2,367
2023-08-16	Kelly James Patrick	EVP, CFO and Treasurer	Other disposed transaction F	Common Stock	1,143	$7.13	$8,150	4,584
2023-08-16	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M	Common Stock	2,366	—	—	5,727
2023-06-25	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Restricted Stock Units	833	$0.00	$0	0
2023-06-25	Trizzino John	EVP, CCO and CBO	Other disposed transaction F	Common Stock	403	$6.70	$2,700	9,490
2023-06-25	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	833	—	—	9,893
2023-06-16	Dubovsky Filip	President, R&D	Exercise / conversion M · derivative	Restricted Stock Units	4,155	$0.00	$0	0
2023-06-16	Dubovsky Filip	President, R&D	Other disposed transaction F	Common Stock	2,007	$8.04	$16,136	45,058
2023-06-16	Dubovsky Filip	President, R&D	Exercise / conversion M	Common Stock	4,155	$8.04	$33,406	47,065
2023-06-12	YOUNG JAMES F	Dir	Equity grant / award A · derivative	Restricted Stock Units	6,670	$0.00	$0	6,670
2023-06-12	YOUNG JAMES F	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	7,710	$0.00	$0	7,710
2023-06-12	Rodgers Richard J	Dir	Equity grant / award A · derivative	Restricted Stock Units	6,670	$0.00	$0	6,670
2023-06-12	Rodgers Richard J	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	7,710	$0.00	$0	7,710
2023-06-10	YOUNG JAMES F	Dir	Exercise / conversion M · derivative	Restricted Stock Units	4,600	$0.00	$0	0
2023-06-10	YOUNG JAMES F	Dir	Exercise / conversion M	Common Stock	4,600	—	—	68,590
2023-03-10	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Restricted Stock Units	6,298	$0.00	$0	12,596
2023-03-10	Glenn Gregory M	President, R&D	Other disposed transaction F	Common Stock	2,432	$6.52	$15,857	18,339
2023-03-10	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	6,298	$6.52	$41,063	20,771
2023-03-10	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	1,000	$6.50	$6,500	14,473
2023-03-10	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Restricted Stock Units	4,609	$0.00	$0	9,216
2023-03-10	Trizzino John	EVP, CCO and CBO	Other disposed transaction F	Common Stock	2,471	$6.52	$16,111	9,060
2023-03-10	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	4,609	$6.52	$30,051	11,531
2023-03-07	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	2,000	$7.04	$14,088	13,473
2023-03-07	Trizzino John	EVP, CCO and CBO	Equity grant / award A · derivative	Restricted Stock Units	86,670	$0.00	$0	86,670
2023-03-07	Trizzino John	EVP, CCO and CBO	Equity grant / award A · derivative	Stock Option (Right to Buy)	100,100	$0.00	$0	100,100
2023-03-06	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	3,000	$7.48	$22,454	11,473
2023-03-01	O'Hara Elaine	EVP, Chief Strategy Officer	Equity grant / award A · derivative	Restricted Stock Units	58,800	$0.00	$0	58,800
2023-03-01	O'Hara Elaine	EVP, Chief Strategy Officer	Equity grant / award A · derivative	Stock Option (Right to buy)	67,900	$0.00	$0	67,900
2023-01-23	Jacobs John C	President and CEO	Equity grant / award A · derivative	Restricted Stock Units	249,590	$0.00	$0	249,590
2023-01-23	Jacobs John C	President and CEO	Equity grant / award A · derivative	Stock Option (Right to buy)	290,700	$0.00	$0	290,700
2022-12-14	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Restricted Stock Units	1,600	$0.00	$0	1,600
2022-12-14	Trizzino John	EVP, CCO and CBO	Other disposed transaction F	Common Stock	773	$17.23	$13,319	6,922
2022-12-14	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	1,600	—	—	7,695
2022-10-29	Rodgers Richard J	Dir	Equity grant / award A · derivative	Restricted Stock Units	11,400	$0.00	$0	11,400
2022-10-29	Rodgers Richard J	Dir	Equity grant / award A · derivative	Stock Option (Right to buy)	17,095	$0.00	$0	17,095
2022-09-26	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Restricted Stock Units	3,538	$0.00	$0	0
2022-09-26	Trizzino John	EVP, CCO and CBO	Other disposed transaction F	Common Stock	1,709	$18.87	$32,249	6,095
2022-09-26	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	3,538	—	—	7,804
2022-08-24	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Restricted Stock Units	2,000	$0.00	$0	0
2022-08-24	Herrmann John A III	EVP, Chief Legal Officer	Other disposed transaction F	Common Stock	772	$37.07	$28,618	2,975
2022-08-24	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,000	—	—	3,747
2022-08-19	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Restricted Stock Units	655	$0.00	$0	1,310
2022-08-19	Trizzino John	EVP, CCO and CBO	Other disposed transaction F	Common Stock	317	$36.22	$11,482	4,266
2022-08-19	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	655	—	—	4,583
2022-08-16	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M · derivative	Restricted Stock Units	2,367	$0.00	$0	4,733
2022-08-16	Kelly James Patrick	EVP, CFO and Treasurer	Other disposed transaction F	Common Stock	1,144	$42.88	$49,055	1,223
2022-08-16	Kelly James Patrick	EVP, CFO and Treasurer	Exercise / conversion M	Common Stock	2,367	—	—	2,367
2022-06-25	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Restricted Stock Units	833	$0.00	$0	833
2022-06-25	Trizzino John	EVP, CCO and CBO	Other disposed transaction F	Common Stock	278	$51.67	$14,364	3,928
2022-06-25	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	833	—	—	4,206
2022-06-17	YOUNG JAMES F	Dir	Exercise / conversion M · derivative	Restricted Stock Units	1,400	$0.00	$0	0
2022-06-17	YOUNG JAMES F	Dir	Exercise / conversion M	Common Stock	1,400	—	—	63,990
2022-06-16	MCMANUS MICHAEL A JR	Dir	Exercise / conversion M · derivative	Restricted Stock Units	700	$0.00	$0	0
2022-06-16	MCMANUS MICHAEL A JR	Dir	Exercise / conversion M	Common Stock	700	—	—	10,101
2022-06-10	MOTT DAVID M	Dir	Equity grant / award A · derivative	Restricted Stock Units	3,100	$0.00	$0	3,100
2022-06-10	MOTT DAVID M	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	4,600	$0.00	$0	4,600
2022-03-31	YOUNG JAMES F	Dir	Open-market sell S	Common Stock	300	$75.10	$22,531	62,590
2022-03-31	YOUNG JAMES F	Dir	Open-market sell S	Common Stock	3,255	$74.25	$241,684	62,890
2022-03-31	YOUNG JAMES F	Dir	Open-market sell S	Common Stock	8,945	$73.29	$655,550	66,145
2022-03-10	Trizzino John	EVP, CCO and CBO	Equity grant / award A · derivative	Restricted Stock Units	13,825	$0.00	$0	13,825
2022-03-10	Trizzino John	EVP, CCO and CBO	Equity grant / award A · derivative	Stock Option (Right to Buy)	20,737	$0.00	$0	20,737
2022-01-03	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,000	$0.00	$0	80,000
2022-01-03	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	100	$144.43	$14,443	3,845
2022-01-03	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,003	$143.64	$144,070	3,945
2022-01-03	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	800	$142.65	$114,117	4,948
2022-01-03	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	500	$140.05	$70,026	6,548
2022-01-03	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	997	$139.08	$138,660	7,048
2022-01-03	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	400	$137.85	$55,140	8,045
2022-01-03	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	5,000	$19.08	$95,400	8,845
2021-12-31	YOUNG JAMES F	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,750	$0.00	$0	0
2021-12-31	YOUNG JAMES F	Dir	Open-market sell S	Common Stock	3,750	$144.16	$540,601	75,090
2021-12-31	YOUNG JAMES F	Dir	Exercise / conversion M	Common Stock	3,750	$25.60	$96,000	78,840
2021-12-20	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,000	$0.00	$0	85,000
2021-12-20	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	5,000	$230.00	$1,150,000	3,845
2021-12-20	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	5,000	$19.08	$95,400	8,845
2021-12-14	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Restricted Stock Units	1,600	$0.00	$0	3,200
2021-12-14	Trizzino John	EVP, CCO and CBO	Other disposed transaction F	Common Stock	773	$168.43	$130,196	3,373
2021-12-14	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	1,600	—	—	4,146
2021-12-13	DOUGLAS RICHARD	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,500	$0.00	$0	0
2021-12-13	DOUGLAS RICHARD	Dir	Exercise / conversion M	Common Stock	1,500	$25.60	$38,400	33,450
2021-12-07	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,250	$0.00	$0	82,500
2021-12-07	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	853	$182.30	$155,498	4,161
2021-12-07	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	500	$180.29	$90,147	5,014
2021-12-07	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	800	$176.19	$140,956	6,514
2021-12-07	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	900	$175.13	$157,619	7,314
2021-12-07	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	400	$168.77	$67,508	8,614
2021-12-07	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	300	$167.06	$50,118	9,014
2021-12-07	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	397	$153.53	$60,951	11,614
2021-12-07	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	100	$182.96	$18,296	4,061
2021-12-07	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	200	$173.13	$34,627	8,214
2021-12-07	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	8,250	$19.08	$157,410	12,311
2021-12-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,000	$0.00	$0	90,000
2021-12-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	366	$202.36	$74,064	2,760
2021-12-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	400	$198.35	$79,340	3,726
2021-12-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	300	$200.92	$60,276	3,126
2021-12-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	943	$196.11	$184,932	4,426
2021-12-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	900	$194.54	$175,085	5,369
2021-12-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	800	$193.79	$155,034	6,269
2021-12-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	691	$192.64	$133,113	7,069
2021-12-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	5,000	$19.08	$95,400	7,760
2021-11-30	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,250	$0.00	$0	90,750
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	100	$211.75	$21,175	4,061
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	551	$210.57	$116,026	4,161
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	879	$209.81	$184,419	4,712
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,450	$208.78	$302,727	5,591
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	353	$207.19	$73,139	7,041
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	439	$206.06	$90,462	7,394
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	465	$203.79	$94,764	7,833
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	715	$202.37	$144,692	8,298
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	338	$201.23	$68,015	9,013
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	717	$200.40	$143,690	9,351
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	678	$199.25	$135,091	10,068
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	836	$198.17	$165,670	10,746
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	356	$197.31	$70,242	11,582
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	518	$195.87	$101,460	11,938
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	200	$194.62	$38,923	12,456
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	222	$192.58	$42,752	12,656
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	4	$191.29	$765	12,878
2021-11-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	121	$189.98	$22,987	12,882
2021-11-30	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	8,250	$19.08	$157,410	13,003
2021-11-29	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,000	$0.00	$0	95,000
2021-11-29	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	5,000	$228.72	$1,143,600	2,760
2021-11-29	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	5,000	$19.08	$95,400	7,760
2021-11-26	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Appreciation Right	1,377	$0.00	$0	30,296
2021-11-26	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,083	$0.00	$0	45,834
2021-11-26	Glenn Gregory M	President, R&D	Other disposed transaction F	Common Stock	647	$217.97	$141,027	4,753
2021-11-26	Glenn Gregory M	President, R&D	Other disposed transaction D	Common Stock	38	$217.97	$8,283	5,400
2021-11-26	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	1,377	$5.95	$8,193	5,438
2021-11-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	114	$221.24	$25,222	4,061
2021-11-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	155	$220.22	$34,134	4,175
2021-11-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	412	$219.25	$90,333	4,330
2021-11-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	626	$218.25	$136,627	4,742
2021-11-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	331	$217.36	$71,946	5,368
2021-11-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	260	$216.19	$56,209	5,699
2021-11-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	185	$215.00	$39,776	5,959
2021-11-26	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	2,083	$5.95	$12,394	6,144
2021-11-23	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,250	$0.00	$0	99,000
2021-11-23	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	200	$203.62	$40,723	4,061
2021-11-23	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	870	$202.65	$176,302	4,261
2021-11-23	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	722	$201.48	$145,468	5,131
2021-11-23	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,600	$200.55	$320,887	5,853
2021-11-23	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,387	$199.51	$276,720	7,453
2021-11-23	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,271	$198.47	$252,252	8,840
2021-11-23	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,400	$197.44	$276,419	10,111
2021-11-23	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	800	$196.43	$157,143	11,511
2021-11-23	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	8,250	$19.08	$157,410	12,311
2021-11-16	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,250	$0.00	$0	107,250
2021-11-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	600	$170.94	$102,562	4,061
2021-11-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	4,352	$170.26	$740,977	4,661
2021-11-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,326	$168.91	$223,969	9,013
2021-11-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,472	$167.95	$247,225	10,339
2021-11-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	500	$166.89	$83,446	11,811
2021-11-16	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	8,250	$19.08	$157,410	12,311
2021-11-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	662	$0.00	$0	8,606
2021-11-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	521	$0.00	$0	1,024
2021-11-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,183	$172.02	$203,496	4,061
2021-11-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	662	$46.00	$30,452	5,244
2021-11-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	521	$27.60	$14,380	4,582
2021-11-09	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,250	$0.00	$0	115,500
2021-11-09	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	100	$171.48	$17,148	4,061
2021-11-09	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,478	$169.54	$250,582	4,561
2021-11-09	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	672	$168.46	$113,204	6,039
2021-11-09	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	2,000	$167.76	$335,517	6,711
2021-11-09	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,800	$166.55	$299,783	8,711
2021-11-09	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,400	$165.72	$232,013	10,511
2021-11-09	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	400	$170.55	$68,219	4,161
2021-11-09	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	8,250	$19.08	$157,410	12,311
2021-11-03	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,000	$0.00	$0	100,000
2021-11-03	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	5,000	$200.00	$1,000,000	2,760
2021-11-03	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	5,000	$19.08	$95,400	7,760
2021-11-02	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,250	$0.00	$0	123,750
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	200	$196.24	$39,248	4,161
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	378	$195.54	$73,913	4,361
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	400	$193.16	$77,262	5,039
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	100	$197.51	$19,751	4,061
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	300	$194.40	$58,320	4,739
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	500	$186.09	$93,047	6,139
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	302	$184.82	$55,815	6,639
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	800	$183.57	$146,860	6,941
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	670	$181.55	$121,637	8,341
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	900	$179.09	$161,180	9,611
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,200	$178.12	$213,749	10,511
2021-11-02	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	600	$182.58	$109,547	7,741
2021-11-02	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	8,250	$19.08	$157,410	12,311
2021-11-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,000	$0.00	$0	105,000
2021-11-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	157	$173.15	$27,185	2,760
2021-11-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	500	$170.88	$85,441	3,217
2021-11-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	200	$169.04	$33,809	3,717
2021-11-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	100	$162.69	$16,269	5,017
2021-11-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	343	$159.90	$54,847	5,517
2021-11-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	800	$157.42	$125,936	6,260
2021-11-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	300	$172.44	$51,733	2,917
2021-11-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	400	$168.32	$67,328	3,917
2021-11-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	5,000	$19.08	$95,400	7,760
2021-10-29	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	26	$152.16	$3,956	4,061
2021-10-29	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	16	$149.64	$2,394	4,087
2021-10-29	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	353	$148.99	$52,592	4,103
2021-10-29	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	138	$148.08	$20,435	4,456
2021-10-29	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	108	$146.51	$15,823	4,594
2021-10-29	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	39	$145.41	$5,671	4,702
2021-10-26	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Appreciation Right	1,378	$0.00	$0	31,673
2021-10-26	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,250	$0.00	$0	132,000
2021-10-26	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,084	$0.00	$0	47,917
2021-10-26	Glenn Gregory M	President, R&D	Other disposed transaction F	Common Stock	637	$134.99	$85,989	4,741
2021-10-26	Glenn Gregory M	President, R&D	Other disposed transaction D	Common Stock	61	$134.99	$8,234	5,378
2021-10-26	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	1,378	$5.95	$8,199	5,439
2021-10-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,000	$135.16	$135,160	4,061
2021-10-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,700	$133.82	$227,499	5,061
2021-10-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	3,134	$133.02	$416,876	6,761
2021-10-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	3,000	$131.91	$395,730	9,895
2021-10-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,500	$130.93	$196,402	12,895
2021-10-26	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	8,250	$19.08	$157,410	14,395
2021-10-26	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	2,084	$5.95	$12,400	6,145
2021-10-19	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,250	$0.00	$0	140,250
2021-10-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	100	$172.03	$17,203	4,061
2021-10-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	300	$169.85	$50,954	4,561
2021-10-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	800	$168.49	$134,794	4,861
2021-10-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,366	$167.08	$228,235	5,661
2021-10-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,000	$165.98	$165,984	7,027
2021-10-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,400	$164.85	$230,786	8,027
2021-10-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	400	$171.01	$68,406	4,161
2021-10-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	893	$162.05	$144,710	9,827
2021-10-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,591	$161.00	$256,152	10,720
2021-10-19	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	8,250	$19.08	$157,410	12,311
2021-10-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	662	$0.00	$0	9,268
2021-10-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	521	$0.00	$0	1,545
2021-10-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,183	$170.00	$201,110	4,061
2021-10-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	662	$46.00	$30,452	5,244
2021-10-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	521	$27.60	$14,380	4,582
2021-10-12	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,250	$0.00	$0	148,500
2021-10-12	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	300	$166.78	$50,033	4,061
2021-10-12	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	392	$165.70	$64,954	4,361
2021-10-12	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	800	$164.50	$131,601	4,753
2021-10-12	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	2,858	$163.38	$466,945	5,553
2021-10-12	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	2,900	$162.45	$471,103	8,411
2021-10-12	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,000	$161.58	$161,582	11,311
2021-10-12	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	8,250	$19.08	$157,410	12,311
2021-10-05	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,250	$0.00	$0	156,750
2021-10-05	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	200	$183.14	$36,628	4,061
2021-10-05	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	179	$182.05	$32,586	4,261
2021-10-05	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	400	$180.41	$72,164	4,440
2021-10-05	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	300	$177.31	$53,194	5,840
2021-10-05	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	500	$176.49	$88,244	6,140
2021-10-05	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	600	$178.37	$107,024	5,240
2021-10-05	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	700	$174.12	$121,887	7,240
2021-10-05	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	2,200	$171.86	$378,088	8,640
2021-10-05	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,471	$170.80	$251,240	10,840
2021-10-05	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	8,250	$19.08	$157,410	12,311
2021-10-04	Erck Stanley C	President and CEO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	10,829	$0.00	$0	0
2021-10-04	Erck Stanley C	President and CEO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	32,000	$0.00	$0	36,499
2021-10-04	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	500	$180.58	$90,290	23,879
2021-10-04	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	3,300	$179.48	$592,282	24,379
2021-10-04	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	8,563	$178.46	$1,528,182	27,679
2021-10-04	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	8,890	$177.58	$1,578,724	36,242
2021-10-04	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	4,700	$176.48	$829,434	45,132
2021-10-04	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	3,600	$175.61	$632,198	49,832
2021-10-04	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	3,100	$174.56	$541,142	53,432
2021-10-04	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	5,038	$173.45	$873,829	56,532
2021-10-04	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	3,746	$172.36	$645,672	61,570
2021-10-04	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	1,392	$166.98	$232,441	65,316
2021-10-04	Erck Stanley C	President and CEO	Exercise / conversion M	Common Stock	10,829	$27.00	$292,383	66,708
2021-10-04	Erck Stanley C	President and CEO	Exercise / conversion M	Common Stock	32,000	$27.60	$883,200	55,879
2021-10-01	Erck Stanley C	President and CEO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	35,000	$0.00	$0	10,829
2021-10-01	Erck Stanley C	President and CEO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	14,000	$0.00	$0	68,499
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	472	$190.63	$89,978	23,879
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	1,502	$189.47	$284,584	24,351
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	100	$187.95	$18,795	25,853
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	8	$185.71	$1,486	25,953
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	192	$183.61	$35,253	25,961
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	300	$182.40	$54,721	26,153
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	1,600	$181.21	$289,934	26,453
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	2,541	$180.42	$458,457	28,053
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	1,323	$179.29	$237,200	30,594
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	4,604	$178.27	$820,753	31,917
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	6,227	$177.37	$1,104,474	36,521
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	2,601	$176.24	$458,388	42,748
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	3,602	$175.15	$630,878	45,349
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	5,853	$174.30	$1,020,176	48,951
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	3,002	$173.16	$519,834	54,804
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	4,103	$172.02	$705,815	57,806
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	2,602	$171.34	$445,814	61,909
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	901	$170.07	$153,233	64,511
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	1,959	$169.05	$331,175	65,412
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	2,801	$167.88	$470,240	67,371
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	1,100	$166.62	$183,286	70,172
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	904	$165.68	$149,777	71,272
2021-10-01	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	703	$164.74	$115,812	72,176
2021-10-01	Erck Stanley C	President and CEO	Exercise / conversion M	Common Stock	35,000	$27.00	$945,000	72,879
2021-10-01	Erck Stanley C	President and CEO	Exercise / conversion M	Common Stock	14,000	$27.60	$386,400	37,879
2021-09-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	40	$210.16	$8,406	4,077
2021-09-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	118	$209.27	$24,694	4,117
2021-09-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	117	$207.99	$24,335	4,235
2021-09-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	280	$207.01	$57,962	4,352
2021-09-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	16	$211.39	$3,382	4,061
2021-09-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	55	$203.94	$11,217	4,648
2021-09-30	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	51	$202.84	$10,345	4,703
2021-09-28	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,501	$0.00	$0	95,000
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	156	$230.00	$35,880	2,546
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	323	$228.25	$73,725	2,702
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	148	$224.24	$33,187	3,025
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	255	$222.86	$56,830	3,173
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	49	$220.22	$10,791	3,428
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	421	$219.26	$92,310	3,477
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	226	$218.13	$49,297	3,898
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	247	$216.21	$53,404	4,124
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	318	$214.65	$68,258	4,371
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	30	$213.11	$6,393	4,689
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	100	$211.45	$21,145	4,719
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	112	$209.57	$23,472	4,819
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	312	$208.46	$65,038	4,931
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	382	$207.32	$79,196	5,243
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	990	$206.30	$204,240	5,625
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,452	$205.25	$298,029	6,615
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,141	$204.12	$232,904	8,067
2021-09-28	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	839	$203.26	$170,537	9,208
2021-09-28	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	7,501	$19.08	$143,119	10,047
2021-09-27	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,501	$0.00	$0	102,501
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	70	$249.04	$17,433	2,546
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	297	$248.16	$73,703	2,616
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	212	$244.99	$51,938	3,013
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	53	$243.20	$12,890	3,225
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	114	$240.60	$27,428	3,278
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	569	$239.71	$136,397	3,392
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	100	$246.49	$24,649	2,913
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	267	$236.75	$63,211	4,061
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	369	$235.77	$86,999	4,328
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	849	$234.37	$198,984	4,697
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,270	$233.25	$296,225	5,546
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	924	$231.95	$214,322	6,816
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,365	$231.16	$315,530	7,740
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	628	$230.19	$144,558	9,105
2021-09-27	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	314	$228.69	$71,807	9,733
2021-09-27	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	7,501	$19.08	$143,119	10,047
2021-09-27	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Appreciation Right	1,377	$0.00	$0	33,051
2021-09-27	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,083	$0.00	$0	50,001
2021-09-27	Glenn Gregory M	President, R&D	Other disposed transaction F	Common Stock	648	$231.04	$149,714	4,754
2021-09-27	Glenn Gregory M	President, R&D	Other disposed transaction D	Common Stock	36	$231.04	$8,317	5,402
2021-09-27	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	1,377	$5.95	$8,193	5,438
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	95	$248.13	$23,573	4,061
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	56	$243.98	$13,663	4,156
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	99	$240.37	$23,796	4,212
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	124	$239.04	$29,641	4,311
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	98	$236.29	$23,157	4,492
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	203	$235.10	$47,726	4,590
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	217	$233.87	$50,750	4,793
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	262	$233.24	$61,108	5,010
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	318	$232.00	$73,775	5,272
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	272	$231.07	$62,850	5,590
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	225	$229.99	$51,748	5,862
2021-09-27	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	57	$237.29	$13,526	4,435
2021-09-27	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	2,083	$5.95	$12,394	6,144
2021-09-26	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Restricted Stock Units	3,537	$0.00	$0	3,538
2021-09-26	Trizzino John	EVP, CCO and CBO	Other disposed transaction F	Common Stock	1,709	$248.16	$424,105	2,546
2021-09-26	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	3,537	—	—	4,255
2021-09-23	MOTT DAVID M	Dir	Open-market sell S	Common Stock	1,200	$255.38	$306,460	40,000
2021-09-23	MOTT DAVID M	Dir	Open-market sell S	Common Stock	2,732	$254.46	$695,193	41,200
2021-09-23	MOTT DAVID M	Dir	Open-market sell S	Common Stock	7,744	$253.46	$1,962,805	43,932
2021-09-23	MOTT DAVID M	Dir	Open-market sell S	Common Stock	7,557	$252.56	$1,908,588	51,676
2021-09-23	MOTT DAVID M	Dir	Open-market sell S	Common Stock	5,728	$251.32	$1,439,570	59,233
2021-09-21	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,500	$0.00	$0	110,002
2021-09-21	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	368	$231.11	$85,050	718
2021-09-21	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,515	$230.31	$348,923	1,086
2021-09-21	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	726	$229.03	$166,278	2,601
2021-09-21	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	853	$228.22	$194,674	3,327
2021-09-21	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	585	$227.09	$132,845	4,180
2021-09-21	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,365	$226.24	$308,821	4,765
2021-09-21	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,269	$224.79	$285,262	6,130
2021-09-21	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	819	$223.95	$183,413	7,399
2021-09-21	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	7,500	$19.08	$143,100	8,218
2021-09-20	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,500	$0.00	$0	117,502
2021-09-20	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	112	$232.90	$26,084	718
2021-09-20	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	256	$231.90	$59,366	830
2021-09-20	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	755	$230.69	$174,167	1,086
2021-09-20	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	918	$229.92	$211,063	1,841
2021-09-20	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,307	$228.72	$298,935	2,759
2021-09-20	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	578	$227.87	$131,710	4,066
2021-09-20	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,175	$226.65	$266,311	4,644
2021-09-20	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,032	$225.68	$232,905	5,819
2021-09-20	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	705	$224.77	$158,460	6,851
2021-09-20	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	662	$223.18	$147,747	7,556
2021-09-20	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	7,500	$19.08	$143,100	8,218
2021-09-15	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,000	$0.00	$0	115,000
2021-09-15	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	262	$234.90	$61,543	706
2021-09-15	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,112	$231.91	$257,882	1,268
2021-09-15	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	500	$230.52	$115,260	2,380
2021-09-15	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	800	$229.57	$183,655	2,880
2021-09-15	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	300	$232.57	$69,771	968
2021-09-15	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	520	$227.34	$118,217	3,980
2021-09-15	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	906	$226.34	$205,061	4,500
2021-09-15	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	200	$224.94	$44,987	5,406
2021-09-15	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	100	$223.51	$22,351	5,606
2021-09-15	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	5,000	$19.08	$95,400	5,706
2021-09-14	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,499	$0.00	$0	125,002
2021-09-14	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	216	$241.70	$52,208	718
2021-09-14	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	590	$240.37	$141,819	934
2021-09-14	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	564	$238.95	$134,768	1,524
2021-09-14	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,423	$238.10	$338,821	2,088
2021-09-14	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	799	$237.14	$189,474	3,511
2021-09-14	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,422	$236.16	$335,826	4,310
2021-09-14	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	682	$235.16	$160,377	5,732
2021-09-14	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	905	$233.90	$211,680	6,414
2021-09-14	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	898	$233.17	$209,389	7,319
2021-09-14	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	7,499	$19.08	$143,081	8,217
2021-09-13	Trizzino John	EVP, CCO and CBO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,499	$0.00	$0	132,501
2021-09-13	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	244	$247.33	$60,349	718
2021-09-13	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	333	$245.16	$81,638	962
2021-09-13	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	74	$242.62	$17,954	1,295
2021-09-13	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	66	$238.13	$15,716	1,369
2021-09-13	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	493	$237.84	$117,255	1,435
2021-09-13	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	880	$236.38	$208,015	1,928
2021-09-13	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,293	$235.50	$304,506	2,808
2021-09-13	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,091	$234.26	$255,582	4,101
2021-09-13	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,279	$233.25	$298,326	5,192
2021-09-13	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	1,317	$232.24	$305,866	6,471
2021-09-13	Trizzino John	EVP, CCO and CBO	Open-market sell S	Common Stock	429	$231.29	$99,225	7,788
2021-09-13	Trizzino John	EVP, CCO and CBO	Exercise / conversion M	Common Stock	7,499	$19.08	$143,081	8,217
2021-09-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,000	$0.00	$0	120,000
2021-09-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	600	$256.01	$153,606	806
2021-09-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	344	$250.00	$86,000	2,806
2021-09-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	400	$254.83	$101,932	1,406
2021-09-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	500	$245.82	$122,911	3,550
2021-09-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	300	$246.80	$74,041	3,250
2021-09-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	256	$238.81	$61,134	5,350
2021-09-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	100	$237.23	$23,723	706
2021-09-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	5,000	$19.08	$95,400	5,706
2021-08-31	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	62	$244.03	$15,130	4,061
2021-08-31	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	100	$242.63	$24,263	4,123
2021-08-31	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	209	$241.59	$50,492	4,223
2021-08-31	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	175	$240.58	$42,102	4,432
2021-08-31	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	359	$239.66	$86,039	4,607
2021-08-31	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	320	$238.72	$76,391	4,966
2021-08-31	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	108	$237.14	$25,611	5,286
2021-08-31	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	53	$234.64	$12,436	5,394
2021-08-26	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Appreciation Right	2,754	$0.00	$0	34,428
2021-08-26	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,167	$0.00	$0	52,084
2021-08-26	Glenn Gregory M	President, R&D	Other disposed transaction F	Common Stock	1,296	$230.34	$298,521	5,447
2021-08-26	Glenn Gregory M	President, R&D	Other disposed transaction D	Common Stock	72	$230.34	$16,584	6,743
2021-08-26	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	2,754	$5.95	$16,386	6,815
2021-08-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	346	$238.62	$82,563	4,261
2021-08-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	616	$233.89	$144,078	5,607
2021-08-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	700	$232.89	$163,020	6,223
2021-08-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	400	$237.34	$94,938	4,607
2021-08-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	605	$230.52	$139,463	7,323
2021-08-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	200	$236.13	$47,226	5,007
2021-08-26	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	100	$241.57	$24,157	4,061
2021-08-26	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	4,167	$5.95	$24,794	8,228
2021-08-24	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Restricted Stock Units	2,000	$0.00	$0	2,000
2021-08-24	Herrmann John A III	EVP, Chief Legal Officer	Other disposed transaction F	Common Stock	697	$233.01	$162,408	1,303
2021-08-24	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,000	—	—	2,000
2021-08-19	Trizzino John	EVP, CCO and CBO	Equity grant / award A · derivative	Restricted Stock Units	1,965	$0.00	$0	1,965
2021-08-16	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,322	$0.00	$0	10,592
2021-08-16	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	544	$0.00	$0	2,587
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	14	$248.98	$3,486	4,061
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	51	$246.72	$12,583	4,075
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	50	$244.99	$12,249	4,126
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	107	$242.99	$26,000	4,176
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	78	$240.37	$18,749	4,283
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	61	$239.32	$14,599	4,361
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	63	$237.92	$14,989	4,422
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	48	$236.22	$11,339	4,485
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	13	$234.88	$3,053	4,533
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	177	$234.38	$41,485	4,546
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	153	$233.17	$35,676	4,723
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	274	$232.15	$63,609	4,876
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	204	$231.27	$47,179	5,150
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	219	$230.00	$50,370	5,354
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	101	$228.79	$23,108	5,573
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	141	$227.79	$32,118	5,674
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	57	$225.98	$12,881	5,815
2021-08-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	55	$223.26	$12,279	5,872
2021-08-16	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	1,322	$46.00	$60,812	5,927
2021-08-16	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	544	$27.60	$15,014	4,605
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,062	$0.00	$0	53,626
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	417	$0.00	$0	7,092
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	68	$204.57	$13,911	706
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	58	$203.45	$11,800	774
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	129	$202.58	$26,132	832
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	209	$201.56	$42,126	961
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	256	$200.47	$51,321	1,170
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	224	$199.47	$44,680	1,426
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	317	$198.20	$62,830	1,650
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	485	$197.47	$95,773	1,967
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	313	$196.12	$61,386	2,452
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	263	$195.29	$51,361	2,765
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	423	$194.26	$82,171	3,028
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	151	$193.09	$29,156	3,451
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,062	$5.95	$12,269	3,602
2021-07-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	417	$46.00	$19,182	1,540
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	189	$228.60	$43,205	2,867
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	306	$227.17	$69,515	3,056
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	173	$225.91	$39,083	3,362
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	240	$220.66	$52,959	3,598
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	56	$229.44	$12,849	2,811
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	141	$213.55	$30,110	4,076
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	63	$224.33	$14,133	3,535
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	126	$214.75	$27,059	3,950
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	135	$206.82	$27,920	4,406
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	181	$205.66	$37,225	4,541
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	61	$203.39	$12,407	4,841
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	199	$202.76	$40,348	4,902
2021-07-20	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	119	$204.71	$24,360	4,722
2021-07-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Appreciation Right	4,823	$0.00	$0	37,182
2021-07-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,129	$0.00	$0	56,251
2021-07-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,105	$0.00	$0	11,914
2021-07-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	870	$0.00	$0	3,131
2021-07-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	550	$0.00	$0	0
2021-07-15	Glenn Gregory M	President, R&D	Other disposed transaction F	Common Stock	2,253	$179.14	$403,602	5,220
2021-07-15	Glenn Gregory M	President, R&D	Other disposed transaction D	Common Stock	161	$179.14	$28,842	7,473
2021-07-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	4,823	$5.95	$28,697	7,634
2021-07-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1	$184.27	$184	2,811
2021-07-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	399	$183.81	$73,341	2,812
2021-07-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	300	$182.38	$54,713	3,211
2021-07-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	560	$181.45	$101,610	3,511
2021-07-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	550	$180.57	$99,315	4,071
2021-07-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	796	$179.29	$142,718	4,621
2021-07-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	2,318	$178.19	$413,052	5,417
2021-07-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	730	$177.62	$129,664	7,735
2021-07-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	3,129	$5.95	$18,618	8,465
2021-07-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	1,105	$46.00	$50,830	5,336
2021-07-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	870	$27.60	$24,012	4,231
2021-07-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	550	$27.00	$14,850	3,361
2021-07-01	YOUNG JAMES F	Dir	Exercise / conversion M · derivative	Restricted Stock Units	10,000	$0.00	$0	0
2021-07-01	YOUNG JAMES F	Dir	Exercise / conversion M	Common Stock	10,000	—	—	75,090
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,063	$0.00	$0	55,688
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	417	$0.00	$0	7,509
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	416	$0.00	$0	2,512
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	11	$216.85	$2,385	706
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	192	$216.11	$41,493	717
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	299	$215.16	$64,333	909
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	360	$214.23	$77,122	1,208
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	313	$212.98	$66,664	1,568
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,126	$212.14	$238,866	1,881
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	171	$211.22	$36,119	3,007
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	309	$209.89	$64,857	3,178
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	115	$208.75	$24,007	3,487
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,063	$5.95	$12,275	3,602
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	417	$46.00	$19,182	1,539
2021-06-30	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	416	$27.60	$11,482	1,122
2021-06-25	MCMANUS MICHAEL A JR	Dir	Exercise / conversion M · derivative	Restricted Stock Units	6,900	$0.00	$0	0
2021-06-25	MCMANUS MICHAEL A JR	Dir	Exercise / conversion M	Common Stock	6,900	—	—	12,851
2021-06-25	MCMANUS MICHAEL A JR	Dir	Exercise / conversion M · derivative	Restricted Stock Units	3,450	$0.00	$0	3,450
2021-06-25	MCMANUS MICHAEL A JR	Dir	Exercise / conversion M	Common Stock	3,450	—	—	9,401
2021-06-17	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	2,411	$183.28	$441,887	2,811
2021-06-17	MOTT DAVID M	Dir	Equity grant / award A · derivative	Restricted Stock Units	700	$0.00	$0	700
2021-06-17	MOTT DAVID M	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	1,300	$0.00	$0	1,300
2021-06-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Appreciation Right	4,819	$0.00	$0	42,005
2021-06-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,124	$0.00	$0	59,380
2021-06-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,101	$0.00	$0	13,019
2021-06-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	868	$0.00	$0	4,001
2021-06-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	623	$0.00	$0	0
2021-06-15	Glenn Gregory M	President, R&D	Other disposed transaction F	Common Stock	2,254	$187.07	$421,656	5,222
2021-06-15	Glenn Gregory M	President, R&D	Other disposed transaction D	Common Stock	154	$187.07	$28,809	7,476
2021-06-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	4,819	$5.95	$28,673	7,630
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	448	$200.00	$89,599	2,811
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	200	$198.39	$39,678	3,259
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	310	$196.65	$60,961	3,459
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	188	$195.24	$36,704	3,769
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	335	$194.35	$65,109	3,957
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	557	$193.50	$107,777	4,292
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	121	$192.14	$23,249	4,849
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	261	$191.25	$49,916	4,970
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,387	$190.31	$263,955	5,231
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	53	$189.62	$10,050	6,618
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	8	$187.86	$1,503	6,671
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,810	$187.04	$338,547	6,679
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	37	$186.45	$6,899	8,489
2021-06-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1	$183.53	$184	8,526
2021-06-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	3,124	$5.95	$18,588	8,527
2021-06-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	1,101	$46.00	$50,646	5,403
2021-06-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	868	$27.60	$23,957	4,302
2021-06-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	623	$27.00	$16,821	3,434
2021-06-01	EVANS GARY C	Dir	Open-market sell S	Common Stock	625	$146.50	$91,562	0
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,062	$0.00	$0	57,751
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	417	$0.00	$0	7,926
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	416	$0.00	$0	2,928
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	70	$153.49	$10,744	275
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	95	$152.11	$14,450	345
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	240	$151.08	$36,258	440
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	517	$149.81	$77,452	680
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,109	$148.88	$165,105	1,197
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	864	$147.85	$127,739	2,306
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,062	$5.95	$12,269	3,170
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	417	$46.00	$19,182	1,108
2021-05-28	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	416	$27.60	$11,482	691
2021-05-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	170	$145.83	$24,792	2,811
2021-05-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	162	$144.36	$23,386	2,981
2021-05-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	298	$143.62	$42,799	3,143
2021-05-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	586	$142.12	$83,282	3,441
2021-05-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,018	$141.23	$143,770	4,027
2021-05-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	89	$140.04	$12,464	5,045
2021-05-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	62	$138.29	$8,574	5,134
2021-05-19	King Rachel K.	Dir	Open-market buy P	Common Stock	700	$139.64	$97,748	2,800
2021-05-17	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Appreciation Right	4,819	$0.00	$0	46,824
2021-05-17	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,124	$0.00	$0	62,504
2021-05-17	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,101	$0.00	$0	14,120
2021-05-17	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	868	$0.00	$0	4,869
2021-05-17	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	619	$0.00	$0	623
2021-05-17	Glenn Gregory M	President, R&D	Other disposed transaction F	Common Stock	2,229	$140.16	$312,417	5,196
2021-05-17	Glenn Gregory M	President, R&D	Other disposed transaction D	Common Stock	205	$140.16	$28,733	7,425
2021-05-17	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	4,819	$5.95	$28,673	7,630
2021-05-17	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	3,364	$135.06	$454,353	2,811
2021-05-17	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,348	$133.10	$179,414	6,175
2021-05-17	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,000	$131.50	$131,500	7,523
2021-05-17	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	3,124	$5.95	$18,588	8,523
2021-05-17	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	1,101	$46.00	$50,646	5,399
2021-05-17	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	868	$27.60	$23,957	4,298
2021-05-17	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	619	$27.00	$16,713	3,430
2021-05-07	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	90	$176.60	$15,894	287
2021-05-07	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	100	$176.65	$17,665	377
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Exercise / conversion M · derivative	Stock Appreciation Right	384	$0.00	$0	11,117
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,084	$0.00	$0	60,417
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	521	$0.00	$0	10,423
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	417	$0.00	$0	3,341
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Other disposed transaction F	Common Stock	180	$171.74	$30,913	477
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Other disposed transaction D	Common Stock	14	$171.74	$2,404	657
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Exercise / conversion M	Common Stock	384	$5.95	$2,285	671
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	68	$194.08	$13,198	287
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	246	$192.81	$47,431	355
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	412	$191.53	$78,909	601
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	192	$190.62	$36,599	1,013
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	364	$189.46	$68,962	1,205
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	318	$188.51	$59,945	1,569
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	186	$187.35	$34,848	1,887
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	105	$186.05	$19,536	2,073
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	252	$184.25	$46,430	2,178
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	138	$183.43	$25,313	2,430
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	160	$182.45	$29,192	2,568
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	85	$181.17	$15,399	2,728
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	70	$180.37	$12,626	2,813
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	28	$171.89	$4,813	2,883
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	208	$171.09	$35,586	2,911
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	93	$169.70	$15,782	3,119
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	13	$168.34	$2,188	3,212
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	12	$164.71	$1,977	3,225
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Open-market sell S	Common Stock	72	$163.03	$11,738	3,237
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Exercise / conversion M	Common Stock	2,084	$5.95	$12,400	3,309
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Exercise / conversion M	Common Stock	521	$46.00	$23,966	1,225
2021-05-05	Trizzino John	EVP, CCO, CBO & Interim CFO	Exercise / conversion M	Common Stock	417	$27.60	$11,509	704
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,063	$0.00	$0	59,813
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	416	$0.00	$0	8,343
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	20	$248.26	$4,965	275
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	128	$247.32	$31,657	295
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	192	$246.17	$47,264	423
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	31	$245.02	$7,596	615
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	59	$243.75	$14,381	646
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	145	$243.05	$35,242	705
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	359	$241.81	$86,809	850
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	207	$240.06	$49,693	1,209
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	447	$239.31	$106,973	1,416
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	267	$238.05	$63,559	1,863
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	576	$237.06	$136,548	2,130
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	464	$236.27	$109,629	2,706
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,063	$5.95	$12,275	3,170
2021-04-30	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	416	$46.00	$19,136	1,107
2021-04-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	494	$224.50	$110,905	2,811
2021-04-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	356	$221.67	$78,915	3,305
2021-04-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	437	$220.57	$96,390	3,661
2021-04-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	81	$219.17	$17,753	4,098
2021-04-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	153	$218.48	$33,428	4,179
2021-04-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	284	$217.22	$61,691	4,332
2021-04-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	417	$216.11	$90,117	4,616
2021-04-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	134	$215.01	$28,812	5,033
2021-04-19	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	61	$213.79	$13,041	5,167
2021-04-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Appreciation Right	4,819	$0.00	$0	51,643
2021-04-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,124	$0.00	$0	65,628
2021-04-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,101	$0.00	$0	15,221
2021-04-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	868	$0.00	$0	5,737
2021-04-15	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	619	$0.00	$0	1,242
2021-04-15	Glenn Gregory M	President, R&D	Other disposed transaction F	Common Stock	2,260	$202.09	$456,723	5,228
2021-04-15	Glenn Gregory M	President, R&D	Other disposed transaction D	Common Stock	142	$202.09	$28,697	7,488
2021-04-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	4,819	$202.09	$973,872	7,630
2021-04-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	127	$206.82	$26,266	2,811
2021-04-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	83	$205.69	$17,073	2,938
2021-04-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	152	$204.71	$31,116	3,021
2021-04-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	391	$204.01	$79,767	3,173
2021-04-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	412	$202.85	$83,574	3,564
2021-04-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	833	$201.93	$168,208	3,976
2021-04-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	605	$200.77	$121,464	4,809
2021-04-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	959	$199.86	$191,670	5,414
2021-04-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	717	$198.70	$142,465	6,373
2021-04-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	873	$197.70	$172,594	7,090
2021-04-15	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	560	$196.77	$110,190	7,963
2021-04-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	3,124	$5.95	$18,588	8,523
2021-04-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	1,101	$46.00	$50,646	5,399
2021-04-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	868	$27.60	$23,957	4,298
2021-04-15	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	619	$27.00	$16,713	3,430
2021-04-07	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	191	$178.03	$34,004	287
2021-04-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Appreciation Right	383	$0.00	$0	11,501
2021-04-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,083	$0.00	$0	62,501
2021-04-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	521	$0.00	$0	10,944
2021-04-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	417	$0.00	$0	3,758
2021-04-05	Trizzino John	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	179	$177.29	$31,735	478
2021-04-05	Trizzino John	EVP, Chief Commercial Officer	Other disposed transaction D	Common Stock	13	$177.29	$2,305	657
2021-04-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	383	$177.29	$67,902	670
2021-04-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	3,021	$190.10	$574,292	287
2021-04-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	2,083	$5.95	$12,394	3,308
2021-04-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	521	$46.00	$23,966	1,225
2021-04-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	417	$27.60	$11,509	704
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,062	$0.00	$0	61,876
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	416	$0.00	$0	8,759
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	47	$196.12	$9,218	275
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	56	$194.74	$10,905	322
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	151	$192.82	$29,116	378
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	245	$191.38	$46,888	529
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	252	$190.10	$47,905	774
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	164	$189.06	$31,007	1,026
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,075	$185.73	$199,665	1,354
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	145	$184.59	$26,766	2,429
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	256	$183.35	$46,937	2,574
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	171	$181.86	$31,099	2,830
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	168	$181.09	$30,423	3,001
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,062	$5.95	$12,269	3,169
2021-03-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	416	$46.00	$19,136	1,107
2021-03-25	YOUNG JAMES F	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	37,500	$0.00	$0	0
2021-03-25	YOUNG JAMES F	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	10,000	$0.00	$0	0
2021-03-25	YOUNG JAMES F	Dir	Exercise / conversion M	Common Stock	37,500	$3.98	$149,438	57,500
2021-03-25	YOUNG JAMES F	Dir	Exercise / conversion M	Common Stock	10,000	$27.60	$276,000	20,000
2021-03-23	YOUNG JAMES F	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	10,000	$0.00	$0	0
2021-03-23	YOUNG JAMES F	Dir	Open-market sell S	Common Stock	2,446	$229.41	$561,134	10,000
2021-03-23	YOUNG JAMES F	Dir	Open-market sell S	Common Stock	3,120	$228.42	$712,661	12,446
2021-03-23	YOUNG JAMES F	Dir	Open-market sell S	Common Stock	4,434	$227.43	$1,008,435	15,566
2021-03-23	YOUNG JAMES F	Dir	Exercise / conversion M	Common Stock	10,000	$46.00	$460,000	20,000
2021-03-19	MCMANUS MICHAEL A JR	Dir	Open-market sell S	Common Stock	3,000	$220.57	$661,710	5,951
2021-03-19	MCMANUS MICHAEL A JR	Dir	Open-market sell S	Common Stock	1,000	$221.40	$221,400	8,951
2021-03-15	EVANS GARY C	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	18,000	$0.00	$0	0
2021-03-15	EVANS GARY C	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,500	$0.00	$0	0
2021-03-15	EVANS GARY C	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	0
2021-03-15	EVANS GARY C	Dir	Open-market sell S	Common Stock	14,768	$212.00	$3,130,816	16,099
2021-03-15	EVANS GARY C	Dir	Open-market sell S	Common Stock	9,732	$210.00	$2,043,720	30,867
2021-03-15	EVANS GARY C	Dir	Exercise / conversion M	Common Stock	18,000	$3.98	$71,730	40,599
2021-03-15	EVANS GARY C	Dir	Exercise / conversion M	Common Stock	4,500	$46.00	$207,000	22,599
2021-03-15	EVANS GARY C	Dir	Exercise / conversion M	Common Stock	2,000	$99.80	$199,600	18,099
2021-03-09	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	190	$168.09	$31,937	287
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Appreciation Right	383	$0.00	$0	11,884
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,083	$0.00	$0	64,584
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	521	$0.00	$0	11,465
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	417	$0.00	$0	4,175
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	179	$174.84	$31,296	477
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Other disposed transaction D	Common Stock	14	$174.84	$2,448	656
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	383	$5.95	$2,279	670
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	12	$175.16	$2,102	287
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	186	$173.54	$32,278	299
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	203	$172.24	$34,964	485
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	314	$171.23	$53,767	688
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	336	$170.25	$57,206	1,002
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	91	$168.89	$15,369	1,338
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	167	$167.73	$28,011	1,429
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	263	$166.48	$43,784	1,596
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	162	$163.53	$26,492	1,859
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	172	$160.82	$27,661	2,021
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	101	$159.02	$16,061	2,193
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	160	$157.08	$25,133	2,294
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	135	$155.64	$21,011	2,454
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	185	$154.00	$28,490	2,589
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	312	$153.24	$47,812	2,774
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	150	$152.39	$22,859	3,086
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	72	$150.31	$10,822	3,236
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	2,083	$5.95	$12,394	3,308
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	521	$46.00	$23,966	1,225
2021-03-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	417	$27.60	$11,509	704
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,063	$0.00	$0	63,938
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	416	$0.00	$0	9,175
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	12	$232.35	$2,788	275
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	59	$231.40	$13,653	287
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	38	$230.04	$8,742	346
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	369	$228.64	$84,368	384
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	569	$227.82	$129,628	753
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	538	$226.59	$121,905	1,322
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	248	$225.45	$55,913	1,860
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	120	$224.93	$26,991	2,108
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	188	$223.48	$42,014	2,228
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	227	$222.39	$50,483	2,416
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	250	$221.32	$55,330	2,643
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	168	$220.33	$37,016	2,893
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	109	$219.55	$23,930	3,061
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,063	$5.95	$12,275	3,170
2021-02-26	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	416	$46.00	$19,136	1,107
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	73	$279.20	$20,382	2,811
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	65	$278.27	$18,088	2,884
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	32	$276.23	$8,839	2,949
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	48	$274.63	$13,182	2,981
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	67	$273.61	$18,332	3,029
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	205	$272.43	$55,848	3,096
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	110	$271.16	$29,827	3,301
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	319	$269.93	$86,109	3,411
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	678	$269.23	$182,536	3,730
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	268	$268.19	$71,875	4,408
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	128	$266.68	$34,135	4,676
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	361	$265.52	$95,854	4,804
2021-02-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	80	$264.09	$21,127	5,165
2021-02-16	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Appreciation Right	4,819	$0.00	$0	61,281
2021-02-16	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,124	$0.00	$0	71,876
2021-02-16	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,101	$0.00	$0	17,423
2021-02-16	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	868	$0.00	$0	7,473
2021-02-16	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to Buy)	619	$0.00	$0	2,480
2021-02-16	Glenn Gregory M	President, R&D	Other disposed transaction F	Common Stock	2,275	$262.70	$597,642	5,245
2021-02-16	Glenn Gregory M	President, R&D	Other disposed transaction D	Common Stock	110	$262.70	$28,897	7,520
2021-02-16	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	4,819	$5.95	$28,673	7,630
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	66	$296.58	$19,575	2,811
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	13	$294.05	$3,823	2,877
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	413	$291.57	$120,419	2,890
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	125	$289.89	$36,236	3,303
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	9	$288.80	$2,599	3,428
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	147	$287.41	$42,249	3,437
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	148	$286.26	$42,367	3,584
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	59	$285.30	$16,833	3,732
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	1,204	$284.25	$342,235	3,791
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	955	$283.43	$270,678	4,995
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	653	$282.13	$184,233	5,950
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	522	$281.64	$147,015	6,603
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	156	$280.71	$43,790	7,125
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	236	$278.98	$65,840	7,281
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	377	$277.09	$104,461	7,517
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	129	$275.83	$35,582	7,894
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	225	$274.80	$61,829	8,023
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	137	$273.39	$37,455	8,248
2021-02-16	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	138	$272.42	$37,593	8,385
2021-02-16	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	3,124	$5.95	$18,588	8,523
2021-02-16	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	1,101	$46.00	$50,646	5,399
2021-02-16	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	868	$27.60	$23,957	4,298
2021-02-16	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	619	$27.00	$16,713	3,430
2021-02-09	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	194	$324.50	$62,953	287
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Appreciation Right	384	$0.00	$0	12,267
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,084	$0.00	$0	66,667
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	521	$0.00	$0	11,986
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	417	$0.00	$0	4,592
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	182	$290.18	$52,813	481
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Other disposed transaction D	Common Stock	8	$290.18	$2,321	663
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	384	$5.95	$2,285	671
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	104	$296.96	$30,884	342
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	238	$296.01	$70,451	446
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	625	$295.05	$184,404	684
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	405	$293.96	$119,054	1,309
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	272	$292.91	$79,670	1,714
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	117	$291.79	$34,139	1,986
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	57	$290.86	$16,579	2,103
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	55	$289.45	$15,920	2,160
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	30	$297.82	$8,935	312
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	25	$298.80	$7,470	287
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	1,020	$283.50	$289,171	2,270
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	19	$282.00	$5,358	3,290
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	2,084	$5.95	$12,400	3,309
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	521	$46.00	$23,966	1,225
2021-02-05	Trizzino John	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	417	$27.60	$11,509	704
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,249	$0.00	$0	66,001
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,080	$0.00	$0	9,591
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,085	$0.00	$0	4,592
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,214	$0.00	$0	0
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	394	$0.00	$0	0
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	3,754	$243.25	$913,160	275
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	2,200	$242.20	$532,833	4,029
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	3,331	$241.51	$804,459	6,229
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	4,294	$240.43	$1,032,399	9,560
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,443	$239.04	$344,938	13,854
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	8,249	$5.95	$49,082	15,297
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,080	$46.00	$95,680	7,048
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,085	$27.60	$57,546	4,968
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	2,214	$27.00	$59,778	2,883
2021-02-01	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	394	$27.00	$10,638	669
2021-01-25	Trizzino John	EVP, Chief Commercial Officer	Other disposed transaction D	Common Stock	73	$128.60	$9,388	287
2021-01-25	Trizzino John	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	73	$128.60	$9,388	287
2021-01-07	Trizzino John	EVP, CMO and CBO	Open-market sell S	Common Stock	506	$124.17	$62,830	287
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M · derivative	Stock Appreciation Right	1,149	$0.00	$0	12,651
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	6,249	$0.00	$0	68,751
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,082	$0.00	$0	12,507
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,668	$0.00	$0	5,009
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,214	$0.00	$0	0
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	394	$0.00	$0	0
2021-01-05	Trizzino John	EVP, CMO and CBO	Other disposed transaction F	Common Stock	584	$116.24	$67,884	793
2021-01-05	Trizzino John	EVP, CMO and CBO	Other disposed transaction D	Common Stock	59	$116.24	$6,858	1,377
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M	Common Stock	1,149	$5.95	$6,837	1,436
2021-01-05	Trizzino John	EVP, CMO and CBO	Open-market sell S	Common Stock	349	$115.11	$40,172	287
2021-01-05	Trizzino John	EVP, CMO and CBO	Open-market sell S	Common Stock	1,500	$114.25	$171,378	636
2021-01-05	Trizzino John	EVP, CMO and CBO	Open-market sell S	Common Stock	3,500	$113.29	$396,511	2,136
2021-01-05	Trizzino John	EVP, CMO and CBO	Open-market sell S	Common Stock	4,194	$112.19	$470,525	5,636
2021-01-05	Trizzino John	EVP, CMO and CBO	Open-market sell S	Common Stock	4,164	$111.19	$463,003	9,830
2021-01-05	Trizzino John	EVP, CMO and CBO	Open-market sell S	Common Stock	3,700	$110.25	$407,934	13,994
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M	Common Stock	6,249	$5.95	$37,182	17,694
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M	Common Stock	2,082	$46.00	$95,772	11,445
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M	Common Stock	1,668	$27.60	$46,037	9,363
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M	Common Stock	2,214	$27.00	$59,778	7,695
2021-01-05	Trizzino John	EVP, CMO and CBO	Exercise / conversion M	Common Stock	394	$27.00	$10,638	5,481
2021-01-05	Trizzino John	EVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	511	$116.24	$59,399	866
2020-12-31	DOUGLAS RICHARD	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,000	$0.00	$0	0
2020-12-31	DOUGLAS RICHARD	Dir	Exercise / conversion M	Common Stock	1,000	$50.00	$50,000	28,500
2020-12-14	Herrmann John A III	EVP, Chief Legal Officer	Equity grant / award A · derivative	Restricted Stock Units	6,300	$0.00	$0	6,300
2020-12-14	Herrmann John A III	EVP, Chief Legal Officer	Equity grant / award A · derivative	Stock Option (Right to Buy)	12,700	$0.00	$0	12,700
2020-12-07	MCGLYNN MARGARET G	Dir	Equity grant / award A · derivative	Stock Option (Right to buy)	7,700	$0.00	$0	7,700
2020-12-05	YOUNG JAMES F	Dir	Equity grant / award A · derivative	Restricted Stock Units	20,000	$0.00	$0	20,000
2020-11-16	Erck Stanley C	President and CEO	Exercise / conversion M · derivative	Stock Option (Right to buy)	9,818	$0.00	$0	35,182
2020-11-16	Erck Stanley C	President and CEO	Exercise / conversion M · derivative	Stock Option (Right to buy)	42,499	$0.00	$0	0
2020-11-16	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	4,909	$93.56	$459,292	20,495
2020-11-16	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	17,503	$92.97	$1,627,291	25,404
2020-11-16	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	4,598	$90.61	$416,638	42,907
2020-11-16	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	11,234	$89.26	$1,002,709	47,505
2020-11-16	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	8,306	$88.36	$733,918	58,739
2020-11-16	Erck Stanley C	President and CEO	Open-market sell S	Common Stock	5,766	$87.20	$502,819	67,045
2020-11-16	Erck Stanley C	President and CEO	Exercise / conversion M	Common Stock	9,818	$25.60	$251,341	72,811
2020-11-16	Erck Stanley C	President and CEO	Exercise / conversion M	Common Stock	42,499	$39.80	$1,691,460	62,993
2020-10-31	Alton Gregg H	Dir	Equity grant / award A · derivative	Stock Option (Right to buy)	7,700	$0.00	$0	7,700
2020-09-30	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	109	$115.08	$12,544	5,087
2020-09-30	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	214	$114.03	$24,402	5,196
2020-09-30	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	58	$112.78	$6,541	5,410
2020-09-30	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	160	$112.03	$17,925	5,468
2020-09-30	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	332	$110.85	$36,802	5,628
2020-09-30	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	353	$109.59	$38,686	5,960
2020-09-30	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	945	$108.57	$102,601	6,313
2020-09-30	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	79	$107.60	$8,501	7,258
2020-09-29	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	1,574	$109.28	$172,001	275
2020-09-29	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	3,419	$108.39	$370,586	1,849
2020-09-29	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	7,061	$107.30	$757,643	5,268
2020-09-29	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	5,975	$106.18	$634,437	1,239
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	24,750	$0.00	$0	74,250
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	546	$117.07	$63,901	18,304
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	941	$116.08	$109,242	18,850
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	992	$115.23	$114,365	19,791
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	397	$113.81	$45,183	20,783
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	720	$113.02	$81,326	21,180
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	213	$111.92	$23,882	21,900
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	2,320	$110.97	$257,424	22,113
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	8,052	$109.98	$885,495	24,433
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	6,595	$109.07	$719,281	32,485
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	3,702	$108.20	$400,515	39,079
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Open-market sell S	Common Stock	273	$107.22	$29,264	42,781
2020-09-28	Herrmann John A III	EVP, Chief Legal Officer	Exercise / conversion M	Common Stock	24,750	$5.95	$147,262	43,054
2020-09-26	Erck Stanley C	President and CEO	Exercise / conversion M · derivative	Restricted Stock Units	6,546	$0.00	$0	13,092
2020-09-26	Erck Stanley C	President and CEO	Other disposed transaction F	Common Stock	2,434	$113.56	$276,405	24,606
2020-09-26	Erck Stanley C	President and CEO	Exercise / conversion M	Common Stock	6,546	—	—	27,040
2020-08-24	Herrmann John A III	EVP, Chief Legal Officer	Equity grant / award A · derivative	Stock Option (Right to Buy)	125,000	$0.00	$0	125,000
2020-08-18	Trizzino John	EVP, CBO and CFO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	10,410	$0.00	$0	14,589
2020-08-18	Trizzino John	EVP, CBO and CFO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	13,322	$0.00	$0	6,677
2020-08-18	Trizzino John	EVP, CBO and CFO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,952	$0.00	$0	4,298
2020-08-18	Trizzino John	EVP, CBO and CFO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,855	$0.00	$0	394
2020-08-18	Trizzino John	EVP, CBO and CFO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	11,249	$0.00	$0	0
2020-08-18	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	1,300	$153.95	$200,135	5,087
2020-08-18	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	1,708	$153.16	$261,597	6,387
2020-08-18	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	4,199	$152.22	$639,172	8,095
2020-08-18	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	4,010	$150.85	$604,908	12,294
2020-08-18	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	1,800	$149.83	$269,694	16,304
2020-08-18	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	6,600	$149.08	$983,928	18,104
2020-08-18	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	9,101	$147.99	$1,346,857	24,704
2020-08-18	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	8,094	$146.95	$1,189,413	33,805
2020-08-18	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	4,900	$146.21	$716,429	41,899
2020-08-18	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	300	$143.99	$43,197	46,799
2020-08-18	Trizzino John	EVP, CBO and CFO	Open-market sell S	Common Stock	776	$142.85	$110,852	47,099
2020-08-18	Trizzino John	EVP, CBO and CFO	Exercise / conversion M	Common Stock	10,410	$46.00	$478,860	47,875
2020-08-18	Trizzino John	EVP, CBO and CFO	Exercise / conversion M	Common Stock	13,322	$27.60	$367,687	37,465
2020-08-18	Trizzino John	EVP, CBO and CFO	Exercise / conversion M	Common Stock	1,952	$27.00	$52,704	24,143
2020-08-18	Trizzino John	EVP, CBO and CFO	Exercise / conversion M	Common Stock	5,855	$27.00	$158,085	22,191
2020-08-18	Trizzino John	EVP, CBO and CFO	Exercise / conversion M	Common Stock	11,249	$99.80	$1,122,650	16,336
2020-06-25	Trizzino John	EVP, CBO and CFO	Equity grant / award A · derivative	Restricted Stock Units	2,500	$0.00	$0	2,500
2020-06-18	Glenn Gregory M	President, R&D	Exercise / conversion M · derivative	Stock Option (Right to buy)	16,749	$0.00	$0	0
2020-06-18	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	16,749	$59.53	$997,103	1,839
2020-06-18	Glenn Gregory M	President, R&D	Exercise / conversion M	Common Stock	16,749	$42.20	$706,808	18,588
2020-06-16	MOTT DAVID M	Dir	Equity grant / award A · derivative	Stock Option (Right to buy)	8,000	$0.00	$0	8,000
2020-06-03	YOUNG JAMES F	Dir	Open-market buy P	Common Stock	1,500	$48.83	$73,245	1,500
2020-05-18	Herrmann John A III	SVP, General Counsel	Exercise / conversion M · derivative	Stock Option (Right to buy)	5,462	$0.00	$0	787
2020-05-18	Herrmann John A III	SVP, General Counsel	Exercise / conversion M · derivative	Stock Option (Right to buy)	7,499	$0.00	$0	0
2020-05-18	Herrmann John A III	SVP, General Counsel	Open-market sell S	Common Stock	5,462	$49.44	$270,041	275
2020-05-18	Herrmann John A III	SVP, General Counsel	Exercise / conversion M	Common Stock	5,462	$27.00	$147,474	5,737
2020-05-18	Herrmann John A III	SVP, General Counsel	Open-market sell S	Common Stock	7,499	$49.44	$370,751	275
2020-05-18	Herrmann John A III	SVP, General Counsel	Exercise / conversion M	Common Stock	7,499	$25.60	$191,974	7,774
2020-03-08	Herrmann John A III	SVP, General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	449	$0.00	$0	0
2020-03-08	Herrmann John A III	SVP, General Counsel	Other disposed transaction F	Common Stock	174	$12.48	$2,172	275
2020-03-08	Herrmann John A III	SVP, General Counsel	Exercise / conversion M	Common Stock	449	—	—	449
2020-01-31	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	1,250	$3.86	$4,825	1,373
2019-12-12	MCMANUS MICHAEL A JR	Dir	Equity grant / award A · derivative	Stock Option (Right to buy)	18,000	$0.00	$0	18,000
2019-12-12	YOUNG JAMES F	Dir	Equity grant / award A · derivative	Stock Option (Right to buy)	37,500	$0.00	$0	37,500
2019-11-18	MCMANUS MICHAEL A JR	Dir	Open-market sell S	Common Stock	3,929	$3.82	$15,015	9,951
2019-09-26	Trizzino John	SVP, CBO and CFO	Equity grant / award A · derivative	Stock Option (Right to Buy)	100,000	$0.00	$0	100,000
2019-09-26	Trizzino John	SVP, CBO and CFO	Equity grant / award A · derivative	Stock Appreciation Right	18,400	$0.00	$0	18,400
2019-09-26	Trizzino John	SVP, CBO and CFO	Equity grant / award A · derivative	Restricted Stock Units	10,613	$0.00	$0	10,613
2019-09-26	Trizzino John	SVP, CBO and CFO	Equity grant / award A · derivative	Restricted Stock Units	31,900	$0.00	$0	31,900
2019-09-17	Herrmann John A III	SVP, General Counsel	Open-market sell S	Common Stock	3,643	$7.07	$25,757	0
2019-09-13	Glenn Gregory M	President, R&D	Open-market sell S	Common Stock	9,620	$6.18	$59,476	123
2019-09-11	Trizzino John	SVP, CBO and CFO	Open-market sell S	Common Stock	5,578	$5.72	$31,911	4,800
2019-09-08	Herrmann John A III	SVP, General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	4,933	$0.00	$0	0
2019-09-08	Herrmann John A III	SVP, General Counsel	Other disposed transaction F	Common Stock	1,643	$5.50	$9,036	3,643
2019-09-08	Herrmann John A III	SVP, General Counsel	Exercise / conversion M	Common Stock	4,933	—	—	5,286
2019-05-13	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	1,000	$5.85	$5,850	74,386
2019-03-27	King Rachel K.	Dir	Open-market buy P	Common Stock	22,000	$0.53	$11,656	22,000
2019-03-27	King Rachel K.	Dir	Open-market buy P	Common Stock	42,000	$0.53	$22,252	42,000
2019-03-08	Herrmann John A III	SVP, General Counsel	Equity grant / award A · derivative	Restricted Stock Units	44,979	$0.00	$0	44,979
2019-03-08	Herrmann John A III	SVP, General Counsel	Equity grant / award A · derivative	Restricted Stock Units	98,676	$0.00	$0	98,676
2019-01-31	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	13,168	$0.88	$11,588	73,386
2018-12-13	Herrmann John A III	SVP, General Counsel	Equity grant / award A · derivative	Stock Option (Right to Buy)	400,000	$0.00	$0	400,000
2018-10-31	King Rachel K.	Dir	Equity grant / award A · derivative	Stock Option (Right to buy)	160,000	$0.00	$0	160,000
2018-07-31	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	13,007	$0.88	$11,446	60,218
2018-05-14	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	19,900	$1.64	$32,636	47,211
2018-05-14	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	100	$1.64	$164	27,311
2018-01-31	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	12,784	$0.88	$11,250	27,211
2017-12-15	Trizzino John	SVP, Commercial Operations	Equity grant / award A · derivative	Stock Option (Right to Buy)	400,000	$0.00	$0	400,000
2017-11-09	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	10,000	$1.13	$11,300	14,427
2017-08-31	YOUNG JAMES F	Dir	Open-market sell S	Common Stock	175,000	$1.06	$184,870	0
2017-07-31	PHILLIPS BARCLAY A	SVP, Chief Financial Officer	Open-market buy P	Common Stock	2,057	$0.89	$1,831	38,669
2017-05-12	MCMANUS MICHAEL A JR	Dir	Open-market buy P	Common Stock	20,000	$0.97	$19,396	277,590
2017-05-11	DOUGLAS RICHARD	Dir	Open-market buy P	Common Stock	200,000	$0.93	$185,780	550,000
2017-03-16	BOUDREAUX GAIL	Dir	Equity grant / award A · derivative	Stock Option (Right to buy)	80,000	$0.00	$0	80,000
2017-03-14	YOUNG JAMES F	Dir	Open-market sell S	Common Stock	100,000	$1.39	$138,980	175,000
2017-01-31	Trizzino John	SVP, Commercial Operations	Open-market buy P	Common Stock	3,401	$1.12	$3,809	88,965
2016-12-07	Glenn Gregory M	President, R&D	Open-market buy P	Common Stock	1,000	$1.45	$1,446	4,427
2016-11-14	Trizzino John	SVP, Commercial Operations	Equity grant / award A · derivative	Stock Option (Right to Buy)	125,000	$0.00	$0	125,000
2016-09-22	Trizzino John	SVP, Commercial Operations	Open-market buy P	Common Stock	46,000	$2.17	$99,820	85,564
2016-09-21	DOUGLAS RICHARD	Dir	Open-market buy P	Common Stock	100,000	$1.72	$172,010	350,000
2016-09-20	BOUDREAUX GAIL	Dir	Open-market buy P	Common Stock	100,000	$1.45	$144,850	200,000
2016-07-31	PHILLIPS BARCLAY A	SVP, Chief Financial Officer	Open-market buy P	Common Stock	422	$4.29	$1,810	9,979
2016-06-06	EVANS GARY C	Dir	Open-market sell S	Common Stock	18,998	$6.50	$123,487	321,979
2016-05-24	EVANS GARY C	Dir	Open-market sell S	Common Stock	16,134	$5.42	$87,495	340,977
2016-05-23	EVANS GARY C	Dir	Open-market sell S	Common Stock	33,866	$5.40	$182,876	357,111

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count