Financial Metrics

ONC BeOne Medicines Ltd.

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-09-30	-0.08	—	USD/shares	10-Q	2017-11-13
Quarterly	2017-09-30	0.2	+350.0%	USD/shares	10-Q	2018-11-08
Quarterly	2018-09-30	-0.19	-195.0%	USD/shares	10-Q	2018-11-08
Quarterly	2020-03-31	-0.36	-89.5%	USD/shares	10-Q	2021-05-06
Quarterly	2021-03-31	0.05	+113.9%	USD/shares	10-Q	2022-05-09
Quarterly	2021-06-30	-0.4	-900.0%	USD/shares	10-Q	2022-08-08
Quarterly	2021-09-30	-0.36	+10.0%	USD/shares	10-Q	2022-11-09
Quarterly	2022-03-31	-0.33	+8.3%	USD/shares	10-Q	2023-05-04
Quarterly	2022-06-30	-0.42	-27.3%	USD/shares	10-Q	2023-08-02
Quarterly	2022-09-30	-0.41	+2.4%	USD/shares	10-Q	2023-11-09
Quarterly	2023-03-31	-0.26	+36.6%	USD/shares	10-Q	2024-05-08
Quarterly	2023-06-30	-0.28	-7.7%	USD/shares	10-Q	2024-08-07
Quarterly	2023-09-30	0.15	+153.6%	USD/shares	10-Q	2024-11-12
Quarterly	2024-03-31	-0.19	-226.7%	USD/shares	10-Q	2025-05-07
Quarterly	2024-06-30	-0.09	+52.6%	USD/shares	10-Q	2025-08-06
Quarterly	2024-09-30	-0.09	+0.0%	USD/shares	10-Q	2025-11-06
Quarterly	2025-03-31	0.0	+100.0%	USD/shares	10-Q	2025-05-07
Quarterly	2025-06-30	0.06	—	USD/shares	10-Q	2025-08-06
Quarterly	2025-09-30	0.08	+33.3%	USD/shares	10-Q	2025-11-06
Annual	2017-12-31	-0.17	—	USD/shares	10-K	2019-02-28
Annual	2019-12-31	-1.22	-617.6%	USD/shares	10-K	2022-02-28
Annual	2020-12-31	-1.5	-23.0%	USD/shares	10-K	2023-02-27
Annual	2021-12-31	-1.21	+19.3%	USD/shares	10-K	2024-02-26
Annual	2022-12-31	-1.49	-23.1%	USD/shares	10-K	2025-02-27
Annual	2023-12-31	-0.65	+56.4%	USD/shares	10-K	2026-02-26
Annual	2024-12-31	-0.47	+27.7%	USD/shares	10-K	2026-02-26
Annual	2025-12-31	0.19	+140.4%	USD/shares	10-K	2026-02-26

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2017-12-31	9222000.0	—	USD	10-Q	2018-11-08
Quarterly	2018-03-31	9565000.0	+3.7%	USD	10-Q	2018-05-09
Quarterly	2018-06-30	51467000.0	+438.1%	USD	10-Q	2018-08-09
Quarterly	2018-09-30	40824000.0	-20.7%	USD	10-Q	2018-11-08
Quarterly	2018-12-31	40785000.0	-0.1%	USD	10-Q	2019-11-12
Quarterly	2019-03-31	77480000.0	+90.0%	USD	10-Q	2019-05-09
Quarterly	2019-06-30	84489000.0	+9.0%	USD	10-Q	2019-08-08
Quarterly	2019-09-30	104233000.0	+23.4%	USD	10-Q	2019-11-12
Quarterly	2019-12-31	83311000.0	-20.1%	USD	10-Q	2020-11-05
Quarterly	2020-03-31	81913000.0	-1.7%	USD	10-Q	2020-05-11
Quarterly	2020-06-30	131491000.0	+60.5%	USD	10-Q	2020-08-06
Quarterly	2020-09-30	151551000.0	+15.3%	USD	10-Q	2020-11-05
Quarterly	2020-12-31	183637000.0	+21.2%	USD	10-Q	2021-11-04
Quarterly	2021-03-31	193017000.0	+5.1%	USD	10-Q	2021-05-06
Quarterly	2021-06-30	194856000.0	+1.0%	USD	10-Q	2021-08-05
Quarterly	2021-09-30	200906000.0	+3.1%	USD	10-Q	2021-11-04
Quarterly	2021-12-31	202113000.0	+0.6%	USD	10-Q	2022-11-09
Quarterly	2022-03-31	201605000.0	-0.3%	USD	10-Q	2022-05-09
Quarterly	2022-06-30	185207000.0	-8.1%	USD	10-Q	2022-08-08
Quarterly	2022-09-30	208058000.0	+12.3%	USD	10-Q	2022-11-09
Quarterly	2022-12-31	209148000.0	+0.5%	USD	10-Q	2023-11-09
Quarterly	2023-03-31	206298000.0	-1.4%	USD	10-Q	2023-05-04
Quarterly	2023-06-30	207426000.0	+0.5%	USD	10-Q	2023-08-02
Quarterly	2023-09-30	202491000.0	-2.4%	USD	10-Q	2023-11-09
Quarterly	2023-12-31	197618000.0	-2.4%	USD	10-Q	2024-11-12
Quarterly	2024-03-31	199027000.0	+0.7%	USD	10-Q	2024-05-08
Quarterly	2024-06-30	185271000.0	-6.9%	USD	10-Q	2024-08-07
Quarterly	2024-09-30	187513000.0	+1.2%	USD	10-Q	2024-11-12
Quarterly	2024-12-31	166484000.0	-11.2%	USD	10-Q	2025-08-06
Quarterly	2025-03-31	160157000.0	-3.8%	USD	10-Q	2025-05-07
Quarterly	2025-06-30	146091000.0	-8.8%	USD	10-Q	2025-08-06
Annual	2016-12-31	17284000.0	—	USD	10-K	2018-02-28
Annual	2017-12-31	9222000.0	-46.6%	USD	10-K	2019-02-28
Annual	2018-12-31	40785000.0	+342.3%	USD	10-K	2020-03-02
Annual	2019-12-31	83311000.0	+104.3%	USD	10-K	2021-02-25
Annual	2020-12-31	183637000.0	+120.4%	USD	10-K	2022-02-28
Annual	2021-12-31	202113000.0	+10.1%	USD	10-K	2023-02-27
Annual	2022-12-31	209148000.0	+3.5%	USD	10-K	2024-02-26
Annual	2023-12-31	197618000.0	-5.5%	USD	10-K	2025-02-27
Annual	2024-12-31	166484000.0	-15.8%	USD	10-K	2026-02-26
Annual	2025-12-31	836369000.0	+402.4%	USD	10-K	2026-02-26

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	3303000.0	—	USD	10-Q	2017-05-10
Quarterly	2016-06-30	8758000.0	+165.2%	USD	10-Q	2017-08-09
Quarterly	2016-09-30	15440000.0	+76.3%	USD	10-Q	2017-11-13
Quarterly	2017-03-31	5068000.0	-67.2%	USD	10-Q	2018-05-09
Quarterly	2017-06-30	8881000.0	+75.2%	USD	10-Q	2018-08-09
Quarterly	2017-09-30	27441000.0	+209.0%	USD	10-Q	2018-11-08
Quarterly	2018-03-31	9696000.0	-64.7%	USD	10-Q	2019-05-09
Quarterly	2018-06-30	20309000.0	+109.5%	USD	10-Q	2019-08-08
Quarterly	2018-09-30	47029000.0	+131.6%	USD	10-Q	2019-11-12
Quarterly	2019-03-31	21828000.0	-53.6%	USD	10-Q	2020-05-11
Quarterly	2019-06-30	43275000.0	+98.3%	USD	10-Q	2020-08-06
Quarterly	2019-09-30	74148000.0	+71.3%	USD	10-Q	2020-11-05
Quarterly	2020-03-31	21533000.0	-71.0%	USD	10-Q	2021-05-06
Quarterly	2020-06-30	54138000.0	+151.4%	USD	10-Q	2021-08-05
Quarterly	2020-09-30	82819000.0	+53.0%	USD	10-Q	2021-11-04
Quarterly	2021-03-31	42389000.0	-48.8%	USD	10-Q	2022-05-09
Quarterly	2021-06-30	80920000.0	+90.9%	USD	10-Q	2022-08-08
Quarterly	2021-09-30	147963000.0	+82.9%	USD	10-Q	2022-11-09
Quarterly	2022-03-31	45131000.0	-69.5%	USD	10-Q	2023-05-04
Quarterly	2022-06-30	95421000.0	+111.4%	USD	10-Q	2023-08-02
Quarterly	2022-09-30	204076000.0	+113.9%	USD	10-Q	2023-11-09
Quarterly	2023-03-31	125585000.0	-38.5%	USD	10-Q	2024-05-08
Quarterly	2023-06-30	247055000.0	+96.7%	USD	10-Q	2024-08-07
Quarterly	2023-09-30	404937000.0	+63.9%	USD	10-Q	2024-11-12
Quarterly	2024-03-31	156578000.0	-61.3%	USD	10-Q	2025-05-07
Quarterly	2024-06-30	266528000.0	+70.2%	USD	10-Q	2025-08-06
Quarterly	2024-09-30	400183000.0	+50.1%	USD	10-Q	2025-11-06
Quarterly	2025-03-31	56407000.0	-85.9%	USD	10-Q	2025-05-07
Quarterly	2025-06-30	100233000.0	+77.7%	USD	10-Q	2025-08-06
Quarterly	2025-09-30	148317000.0	+48.0%	USD	10-Q	2025-11-06
Annual	2016-12-31	23502000.0	—	USD	10-K	2019-02-28
Annual	2017-12-31	46374000.0	+97.3%	USD	10-K	2020-03-02
Annual	2018-12-31	70283000.0	+51.6%	USD	10-K	2021-02-25
Annual	2019-12-31	89612000.0	+27.5%	USD	10-K	2022-02-28
Annual	2020-12-31	117508000.0	+31.1%	USD	10-K	2023-02-27
Annual	2021-12-31	262942000.0	+123.8%	USD	10-K	2024-02-26
Annual	2022-12-31	325434000.0	+23.8%	USD	10-K	2025-02-27
Annual	2023-12-31	561896000.0	+72.7%	USD	10-K	2026-02-26
Annual	2024-12-31	492663000.0	-12.3%	USD	10-K	2026-02-26
Annual	2025-12-31	185839000.0	-62.3%	USD	10-K	2026-02-26

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	294042572.0	—	shares	10-Q	2017-05-10
Quarterly	2016-06-30	427746711.0	+45.5%	shares	10-Q	2017-08-09
Quarterly	2016-09-30	428137509.0	+0.1%	shares	10-Q	2017-11-13
Quarterly	2017-03-31	516437707.0	+20.6%	shares	10-Q	2018-05-09
Quarterly	2017-06-30	517663736.0	+0.2%	shares	10-Q	2018-08-09
Quarterly	2017-09-30	600612680.0	+16.0%	shares	10-Q	2018-11-08
Quarterly	2018-03-31	670510605.0	+11.6%	shares	10-Q	2019-05-09
Quarterly	2018-06-30	698506891.0	+4.2%	shares	10-Q	2019-08-08
Quarterly	2018-09-30	739789269.0	+5.9%	shares	10-Q	2019-11-12
Quarterly	2019-03-31	774750255.0	+4.7%	shares	10-Q	2020-05-11
Quarterly	2019-06-30	777509102.0	+0.4%	shares	10-Q	2020-08-06
Quarterly	2019-09-30	781482459.0	+0.5%	shares	10-Q	2020-11-05
Quarterly	2020-03-31	1005347581.0	+28.6%	shares	10-Q	2021-05-06
Quarterly	2020-06-30	1010230470.0	+0.5%	shares	10-Q	2021-08-05
Quarterly	2020-09-30	1148973077.0	+13.7%	shares	10-Q	2021-11-04
Quarterly	2021-03-31	1257489671.0	+9.4%	shares	10-Q	2022-05-09
Quarterly	2021-06-30	1194071476.0	-5.0%	shares	10-Q	2022-08-08
Quarterly	2021-09-30	1205971284.0	+1.0%	shares	10-Q	2022-11-09
Quarterly	2022-03-31	1332017262.0	+10.5%	shares	10-Q	2023-05-04
Quarterly	2022-06-30	1336463026.0	+0.3%	shares	10-Q	2023-08-02
Quarterly	2022-09-30	1345303747.0	+0.7%	shares	10-Q	2023-11-09
Quarterly	2023-03-31	1354164760.0	+0.7%	shares	10-Q	2024-05-08
Quarterly	2023-06-30	1360224377.0	+0.4%	shares	10-Q	2024-08-07
Quarterly	2023-09-30	1390331833.0	+2.2%	shares	10-Q	2024-11-12
Quarterly	2024-03-31	1355547626.0	-2.5%	shares	10-Q	2025-05-07
Quarterly	2024-06-30	1361082567.0	+0.4%	shares	10-Q	2025-08-06
Quarterly	2024-09-30	1376751873.0	+1.2%	shares	10-Q	2025-11-06
Quarterly	2025-03-31	1445253219.0	+5.0%	shares	10-Q	2025-05-07
Quarterly	2025-06-30	1463277401.0	+1.2%	shares	10-Q	2025-08-06
Quarterly	2025-09-30	1488750354.0	+1.7%	shares	10-Q	2025-11-06
Annual	2016-12-31	403619446.0	—	shares	10-K	2019-02-28
Annual	2017-12-31	543185460.0	+34.6%	shares	10-K	2020-03-02
Annual	2018-12-31	720753819.0	+32.7%	shares	10-K	2021-02-25
Annual	2019-12-31	780701283.0	+8.3%	shares	10-K	2022-02-28
Annual	2020-12-31	1085131783.0	+39.0%	shares	10-K	2023-02-27
Annual	2021-12-31	1206210049.0	+11.2%	shares	10-K	2024-02-26
Annual	2022-12-31	1340729572.0	+11.2%	shares	10-K	2025-02-27
Annual	2023-12-31	1357034547.0	+1.2%	shares	10-K	2026-02-26
Annual	2024-12-31	1368746793.0	+0.9%	shares	10-K	2026-02-26
Annual	2025-12-31	1474829908.0	+7.8%	shares	10-K	2026-02-26

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

836,369,000

Total Liabilities (latest annual)

3,827,379,000

Current Liabilities (latest annual)

1,828,830,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-0.0905	—	ratio	10-Q	2017-05-10
Quarterly	2016-06-30	-0.1096	-21.1%	ratio	10-Q	2017-08-09
Quarterly	2016-09-30	-0.1890	-72.4%	ratio	10-Q	2017-11-13
Quarterly	2017-03-31	-0.1641	+13.1%	ratio	10-Q	2018-05-09
Quarterly	2017-06-30	-0.2246	-36.8%	ratio	10-Q	2018-08-09
Quarterly	2017-09-30	0.1534	+168.3%	ratio	10-Q	2018-11-08
Quarterly	2018-03-31	-0.0774	-150.4%	ratio	10-Q	2019-11-12
Quarterly	2018-06-30	-0.1286	-66.2%	ratio	10-Q	2019-11-12
Quarterly	2018-09-30	-0.0728	+43.3%	ratio	10-Q	2019-11-12
Quarterly	2019-03-31	-0.1036	-42.2%	ratio	10-Q	2020-11-05
Quarterly	2019-06-30	-0.0547	+47.2%	ratio	10-Q	2020-11-05
Quarterly	2019-09-30	-0.2385	-336.0%	ratio	10-Q	2020-11-05
Quarterly	2020-03-31	-0.1291	+45.9%	ratio	10-Q	2021-11-04
Quarterly	2020-06-30	-0.1321	-2.3%	ratio	10-Q	2021-11-04
Quarterly	2020-09-30	-0.0993	+24.8%	ratio	10-Q	2021-11-04
Quarterly	2021-03-31	0.0142	+114.3%	ratio	10-Q	2022-11-09
Quarterly	2021-06-30	-0.1375	-1071.1%	ratio	10-Q	2022-11-09
Quarterly	2021-09-30	-0.1347	+2.0%	ratio	10-Q	2022-11-09
Quarterly	2022-03-31	-0.0754	+44.1%	ratio	10-Q	2023-11-09
Quarterly	2022-06-30	-0.1089	-44.4%	ratio	10-Q	2023-11-09
Quarterly	2022-09-30	-0.1198	-10.0%	ratio	10-Q	2023-11-09
Quarterly	2023-03-31	-0.0838	+30.0%	ratio	10-Q	2024-11-12
Quarterly	2023-06-30	-0.1003	-19.7%	ratio	10-Q	2024-11-12
Quarterly	2023-09-30	0.0572	+157.0%	ratio	10-Q	2024-11-12
Quarterly	2024-03-31	-0.0747	-230.6%	ratio	10-Q	2025-11-06
Quarterly	2024-06-30	-0.0358	+52.1%	ratio	10-Q	2025-11-06
Quarterly	2024-09-30	-0.0353	+1.3%	ratio	10-Q	2025-11-06
Quarterly	2025-03-31	0.0004	+101.0%	ratio	10-Q	2025-11-06
Quarterly	2025-06-30	0.0250	+6793.1%	ratio	10-Q	2025-11-06
Quarterly	2025-09-30	0.0302	+20.9%	ratio	10-Q	2025-11-06
Annual	2016-12-31	-0.3378	—	ratio	10-K	2019-02-28
Annual	2017-12-31	-0.1364	+59.6%	ratio	10-K	2020-03-02
Annual	2018-12-31	-0.3844	-181.9%	ratio	10-K	2021-02-25
Annual	2019-12-31	-1.0108	-163.0%	ratio	10-K	2022-02-28
Annual	2020-12-31	-0.4282	+57.6%	ratio	10-K	2023-02-27
Annual	2021-12-31	-0.2377	+44.5%	ratio	10-K	2024-02-26
Annual	2022-12-31	-0.4571	-92.3%	ratio	10-K	2025-02-27
Annual	2023-12-31	-0.2493	+45.5%	ratio	10-K	2026-02-26
Annual	2024-12-31	-0.1935	+22.4%	ratio	10-K	2026-02-26
Annual	2025-12-31	0.0658	+134.0%	ratio	10-K	2026-02-26

8-K Material Event Details

133 filings · 312 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

1453 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-04-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,274	$0.00	$0	109,122
2026-04-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,729	$0.00	$0	84,955
2026-04-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,313	$0.00	$0	21,177
2026-04-08	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	332	$311.59	$103,448	0
2026-04-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	98	$159.03	$15,585	332
2026-04-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	133	$213.32	$28,372	234
2026-04-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	101	$194.47	$19,641	101
2026-03-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,274	$0.00	$0	110,396
2026-03-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,729	$0.00	$0	86,684
2026-03-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,430	$0.00	$0	22,490
2026-03-11	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	341	$300.00	$102,300	0
2026-03-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	98	$159.03	$15,585	341
2026-03-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	133	$213.32	$28,372	243
2026-03-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	110	$194.47	$21,392	110
2026-03-06	OYLER JOHN	Chief Executive Officer	Equity grant / award A	Ordinary Shares	117,936	$0.00	$0	5,609,275
2026-03-06	OYLER JOHN	Chief Executive Officer	Equity grant / award A	Ordinary Shares	326,976	$0.00	$0	5,491,339
2026-02-04	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	6,448	$0.00	$0	111,670
2026-02-04	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	8,606	$0.00	$0	88,413
2026-02-04	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	6,526	$0.00	$0	23,920
2026-02-04	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	996	$350.00	$348,600	0
2026-02-04	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	664	$348.79	$231,597	996
2026-02-04	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	496	$159.03	$78,879	1,660
2026-02-04	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	662	$213.32	$141,218	1,164
2026-02-04	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	502	$194.47	$97,624	502
2026-01-07	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	2,548	$0.00	$0	118,118
2026-01-07	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	3,458	$0.00	$0	97,019
2026-01-07	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	2,626	$0.00	$0	30,446
2026-01-07	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	664	$331.76	$220,289	0
2026-01-07	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	196	$159.03	$31,170	664
2026-01-07	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	266	$213.32	$56,743	468
2026-01-07	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	202	$194.47	$39,283	202
2025-12-31	Wang Lai	President, Global Head of R&D	Equity grant / award A	Ordinary Shares	427,895	$0.00	$0	1,451,424
2025-12-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	40	$305.24	$12,210	0
2025-12-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,973	$304.36	$600,507	40
2025-12-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,255	$304.13	$381,685	2,013
2025-12-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,442	$303.72	$1,652,855	3,268
2025-12-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,633	$303.13	$495,013	8,710
2025-12-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,470	$302.74	$2,261,492	10,343
2025-12-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,512	$302.31	$457,097	17,813
2025-12-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,567	$301.79	$774,699	19,325
2025-12-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	600	$300.98	$180,586	21,892
2025-12-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,877	$300.80	$564,597	22,492
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,194	$314.92	$376,009	24,369
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	929	$313.52	$291,256	25,563
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	121	$311.93	$37,743	26,492
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,344	$311.33	$729,749	26,613
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	16,318	$310.48	$5,066,489	28,957
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	10,650	$309.37	$3,294,798	45,275
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	14,163	$308.41	$4,368,018	55,925
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,118	$307.38	$1,573,168	70,088
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,949	$306.39	$1,516,335	75,206
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,940	$305.55	$1,203,867	80,155
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,829	$304.37	$1,774,160	84,095
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,896	$303.60	$575,629	89,924
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,389	$302.29	$1,931,331	91,820
2025-12-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,791	$301.58	$540,127	98,209
2025-12-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,274	$0.00	$0	120,666
2025-12-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,729	$0.00	$0	100,477
2025-12-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,313	$0.00	$0	33,072
2025-12-11	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	332	$325.00	$107,900	0
2025-12-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	98	$159.03	$15,585	332
2025-12-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	133	$213.32	$28,372	234
2025-12-11	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	101	$194.47	$19,641	101
2025-12-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,274	$0.00	$0	121,940
2025-12-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,729	$0.00	$0	102,206
2025-12-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,313	$0.00	$0	34,385
2025-12-10	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	332	$318.28	$105,669	0
2025-12-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	98	$159.03	$15,585	332
2025-12-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	133	$213.32	$28,372	234
2025-12-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	101	$194.47	$19,641	101
2025-11-26	Sanders Corazon (Corsee) D.	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	34,151	$0.00	$0	0
2025-11-26	Sanders Corazon (Corsee) D.	Dir	Open-market sell S	American Depositary Shares	804	$342.47	$275,349	0
2025-11-26	Sanders Corazon (Corsee) D.	Dir	Open-market sell S	American Depositary Shares	1,823	$340.20	$620,185	804
2025-11-26	Sanders Corazon (Corsee) D.	Dir	Exercise / conversion M	American Depositary Shares	2,627	$159.03	$417,772	2,627
2025-11-17	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	10	$382.32	$3,823	0
2025-11-17	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	826	$381.19	$314,862	10
2025-11-17	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	3,155	$380.23	$1,199,617	836
2025-11-13	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	1,769	$381.05	$674,077	0
2025-11-13	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	4,240	$380.33	$1,612,583	1,769
2025-11-12	OYLER JOHN	Chief Executive Officer	Equity grant / award G	Ordinary Shares	858,533	$0.00	$0	6,441,041
2025-11-12	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	154	$362.07	$55,759	6,009
2025-11-12	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	4,846	$360.10	$1,745,024	6,163
2025-11-12	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	100	$357.43	$35,743	11,009
2025-11-12	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	120	$355.00	$42,600	11,109
2025-11-12	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	251	$354.20	$88,903	11,229
2025-11-12	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	789	$352.78	$278,341	11,480
2025-11-12	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	3,240	$351.41	$1,138,569	12,269
2025-11-12	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	500	$350.44	$175,220	15,509
2025-11-11	OYLER JOHN	Chief Executive Officer	Equity grant / award G	Ordinary Shares	151,320	$0.00	$0	7,299,574
2025-11-07	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	424,073	$0.00	$0	4,582,601
2025-10-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	3,848	$0.00	$0	127,062
2025-10-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	116,493	$0.00	$0	109,109
2025-10-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	3,926	$0.00	$0	39,624
2025-10-08	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	4,162	$351.12	$1,461,375	0
2025-10-08	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	4,733	$350.22	$1,657,580	4,162
2025-10-08	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	664	$347.82	$230,952	8,895
2025-10-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	296	$159.03	$47,073	9,559
2025-10-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	8,961	$213.32	$1,911,561	9,263
2025-10-08	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	302	$194.47	$58,730	302
2025-10-08	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	1,112	$350.00	$389,200	0
2025-09-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	400	$327.78	$131,112	0
2025-09-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,008	$326.90	$1,310,227	400
2025-09-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	12,446	$326.14	$4,059,091	4,408
2025-09-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,883	$325.06	$2,237,402	16,854
2025-09-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,066	$324.12	$1,317,862	23,737
2025-09-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	3,848	$0.00	$0	130,910
2025-09-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	23,348	$0.00	$0	225,602
2025-09-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M · derivative	Share Option (Right to Buy)	88,426	$0.00	$0	43,550
2025-09-10	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	500	$327.93	$163,965	0
2025-09-10	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	300	$326.80	$98,040	500
2025-09-10	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	3,318	$325.73	$1,080,760	800
2025-09-10	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	4,776	$325.19	$1,553,124	4,118
2025-09-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	296	$159.03	$47,073	8,894
2025-09-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	1,796	$213.32	$383,123	8,598
2025-09-10	Lee Chan Henry	SVP, General Counsel	Exercise / conversion M	American Depositary Shares	6,802	$194.47	$1,322,785	6,802
2025-09-10	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	1,112	$325.00	$361,400	0
2025-09-09	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	148,096	$0.00	$0	5,006,674
2025-09-05	Sanders Corazon (Corsee) D.	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	34,645	$0.00	$0	0
2025-09-05	Sanders Corazon (Corsee) D.	Dir	Open-market sell S	American Depositary Shares	2,665	$337.00	$898,105	0
2025-09-05	Sanders Corazon (Corsee) D.	Dir	Exercise / conversion M	American Depositary Shares	2,665	$155.68	$414,887	2,665
2025-09-02	Ball Titus B.	Principal Accounting Officer	Open-market sell S	American Depositary Shares	122	$326.76	$39,865	0
2025-08-14	Wu Xiaobin	President and COO	Exercise / conversion M · derivative	Share Option (Right to Buy)	119,340	$0.00	$0	358,046
2025-08-14	Wu Xiaobin	President and COO	Exercise / conversion M · derivative	Share Option (Right to Buy)	399,828	$0.00	$0	309,881
2025-08-14	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	600	$308.03	$184,819	0
2025-08-14	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	4,917	$307.43	$1,511,626	600
2025-08-14	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	12,232	$306.26	$3,746,189	5,517
2025-08-14	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	8,522	$305.48	$2,603,297	17,749
2025-08-14	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	500	$304.19	$152,097	26,271
2025-08-14	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	6,965	$303.31	$2,112,586	26,771
2025-08-14	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	5,800	$302.04	$1,751,857	33,736
2025-08-14	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	400	$300.86	$120,345	39,536
2025-08-14	Wu Xiaobin	President and COO	Exercise / conversion M	American Depositary Shares	9,180	$159.03	$1,459,895	39,936
2025-08-14	Wu Xiaobin	President and COO	Exercise / conversion M	American Depositary Shares	30,756	$155.68	$4,788,094	30,756
2025-08-13	Wu Xiaobin	President and COO	Exercise / conversion M · derivative	Share Option (Right to Buy)	352,105	$0.00	$0	709,709
2025-08-13	Wu Xiaobin	President and COO	Exercise / conversion M · derivative	Share Option (Right to Buy)	296,049	$0.00	$0	0
2025-08-13	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	9,617	$307.38	$2,956,062	0
2025-08-13	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	9,637	$306.74	$2,956,094	9,617
2025-08-13	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	528	$305.59	$161,352	19,254
2025-08-13	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	7,359	$304.37	$2,239,887	19,782
2025-08-13	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	3,517	$303.54	$1,067,564	27,141
2025-08-13	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	5,800	$302.45	$1,754,194	30,658
2025-08-13	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	4,500	$301.49	$1,356,703	36,458
2025-08-13	Wu Xiaobin	President and COO	Open-market sell S	American Depositary Shares	8,900	$300.33	$2,672,962	40,958
2025-08-13	Wu Xiaobin	President and COO	Exercise / conversion M	American Depositary Shares	27,085	$155.68	$4,216,593	49,858
2025-08-13	Wu Xiaobin	President and COO	Exercise / conversion M	American Depositary Shares	22,773	$174.43	$3,972,294	22,773
2025-08-01	Rosenberg Aaron	Chief Financial Officer	Open-market sell S	American Depositary Shares	1,190	$290.47	$345,659	0
2025-07-30	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	259	$305.00	$78,995	0
2025-07-30	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	920	$304.60	$280,233	0
2025-07-29	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	800	$304.16	$243,330	259
2025-07-29	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	292	$302.92	$88,454	1,059
2025-07-29	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	2,949	$302.00	$890,596	1,351
2025-07-18	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	700	$300.00	$210,000	0
2025-07-09	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,553	$254.83	$395,757	0
2025-07-09	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	10,254	$254.10	$2,605,577	1,553
2025-07-09	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	9,292	$253.18	$2,352,575	11,807
2025-07-09	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,703	$252.23	$1,690,682	21,099
2025-06-24	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	100	$267.81	$26,781	0
2025-06-24	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	507	$266.57	$135,149	100
2025-06-24	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,100	$265.35	$291,888	607
2025-06-24	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	300	$263.50	$79,050	1,707
2025-06-23	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	1,028	$260.00	$267,280	0
2025-06-16	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	422	$266.50	$112,463	0
2025-06-11	Ball Titus B.	Principal Accounting Officer	Open-market sell S	American Depositary Shares	134	$258.36	$34,620	0
2025-06-10	Ball Titus B.	Principal Accounting Officer	Equity grant / award A	Ordinary Shares	29,601	$0.00	$0	73,983
2025-06-06	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	230	$256.79	$59,063	0
2025-06-06	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	470	$255.78	$120,217	230
2025-05-21	Yi Qingqing	Dir	Equity grant / award A · derivative	Share Option (Right to Buy)	22,750	$0.00	$0	22,750
2025-05-21	Yi Qingqing	Dir	Equity grant / award A	Ordinary Shares	10,985	$0.00	$0	56,940
2025-05-13	Wang Xiaodong	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	542,880	$0.00	$0	542,887
2025-05-13	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	200	$225.68	$45,136	0
2025-05-13	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	10,104	$224.32	$2,266,542	200
2025-05-13	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	21,235	$223.41	$4,744,092	10,304
2025-05-13	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	10,221	$222.83	$2,277,501	31,539
2025-05-13	Wang Xiaodong	Dir	Exercise / conversion M	American Depositary Shares	41,760	$6.50	$271,440	41,760
2025-05-09	OYLER JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Share Option (Right to Buy)	4,055,415	$0.00	$0	7
2025-05-09	OYLER JOHN	Chief Executive Officer	Other disposed transaction F	Ordinary Shares	1,990,603	$17.85	$35,532,264	8,163,437
2025-05-09	OYLER JOHN	Chief Executive Officer	Exercise / conversion M	Ordinary Shares	4,055,415	$0.50	$2,027,708	10,154,040
2025-04-14	Wang Xiaodong	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	542,880	$0.00	$0	1,085,767
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	365	$249.45	$91,050	0
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	535	$248.90	$133,162	365
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,475	$247.46	$365,007	900
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,869	$246.40	$460,516	2,375
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,056	$245.56	$504,876	4,244
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,592	$244.56	$389,337	6,300
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	6,398	$243.41	$1,557,363	7,892
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	15,041	$242.59	$3,648,733	14,290
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,229	$241.51	$538,323	29,331
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	5,516	$240.41	$1,326,124	31,560
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,884	$239.51	$690,755	37,076
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	805	$238.48	$191,976	39,960
2025-04-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	995	$237.56	$236,373	40,765
2025-04-14	Wang Xiaodong	Dir	Exercise / conversion M	American Depositary Shares	41,760	$6.50	$271,440	41,760
2025-04-01	Wu Xiaobin	President, COO & GM China	Exercise / conversion M · derivative	Share Option (Right to Buy)	460,772	$0.00	$0	296,049
2025-04-01	Wu Xiaobin	President, COO & GM China	Exercise / conversion M · derivative	Share Option (Right to Buy)	214,201	$0.00	$0	0
2025-04-01	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	5,083	$283.79	$1,442,521	0
2025-04-01	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	12,221	$282.76	$3,455,641	5,083
2025-04-01	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	6,364	$281.67	$1,792,571	17,304
2025-04-01	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	28,253	$280.31	$7,919,638	23,668
2025-04-01	Wu Xiaobin	President, COO & GM China	Exercise / conversion M	American Depositary Shares	35,444	$174.43	$6,182,497	51,921
2025-04-01	Wu Xiaobin	President, COO & GM China	Exercise / conversion M	American Depositary Shares	16,477	$119.96	$1,976,581	16,477
2025-03-18	Wang Xiaodong	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	542,880	$0.00	$0	1,628,647
2025-03-18	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,107	$264.01	$292,262	0
2025-03-18	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	6,923	$263.08	$1,821,298	1,107
2025-03-18	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	11,245	$262.12	$2,947,557	8,030
2025-03-18	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	10,448	$261.44	$2,731,492	19,275
2025-03-18	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,694	$259.86	$700,063	29,723
2025-03-18	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	6,926	$259.08	$1,794,380	32,417
2025-03-18	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,417	$258.25	$624,200	39,343
2025-03-18	Wang Xiaodong	Dir	Exercise / conversion M	American Depositary Shares	41,760	$6.50	$271,440	41,760
2025-03-14	Wu Xiaobin	President, COO & GM China	Open-market sell S	RMB Shares	0	$0.00	—	0
2025-03-11	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	158,717	$0.00	$0	5,082,165
2025-03-10	OYLER JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,033,552	$0.00	$0	4,055,422
2025-03-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$246.85	$172,793	0
2025-03-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,913	$246.11	$1,209,128	700
2025-03-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,006	$245.19	$737,028	5,613
2025-03-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,313	$244.04	$1,296,584	8,619
2025-03-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	9,309	$243.04	$2,262,455	13,932
2025-03-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,069	$241.92	$1,710,157	23,241
2025-03-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,200	$240.70	$529,533	30,310
2025-03-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,800	$239.59	$1,629,200	32,510
2025-03-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,900	$238.74	$453,605	39,310
2025-03-10	OYLER JOHN	Chief Executive Officer	Exercise / conversion M	American Depositary Shares	41,210	$6.50	$267,865	41,210
2025-03-10	OYLER JOHN	Chief Executive Officer	Exercise / conversion M	Ordinary Shares	497,822	$0.50	$248,911	6,098,625
2025-03-07	OYLER JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,470,417	$0.00	$0	5,088,974
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	500	$256.10	$128,050	0
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,400	$255.02	$612,053	500
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,300	$254.10	$330,326	2,900
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,100	$253.21	$278,526	4,200
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,299	$252.24	$832,127	5,300
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,300	$251.00	$577,304	8,599
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	12,578	$249.97	$3,144,087	10,899
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	8,905	$249.04	$2,217,708	23,477
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,600	$247.99	$1,884,710	32,382
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	13,918	$246.91	$3,436,548	39,982
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,190	$246.69	$293,567	53,900
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,100	$246.09	$516,800	55,090
2025-03-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,400	$246.03	$344,443	57,190
2025-03-07	OYLER JOHN	Chief Executive Officer	Exercise / conversion M	American Depositary Shares	58,590	$6.50	$380,835	58,590
2025-03-07	OYLER JOHN	Chief Executive Officer	Exercise / conversion M	Ordinary Shares	708,747	$0.50	$354,374	5,600,803
2025-03-06	OYLER JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,007,578	$0.00	$0	6,559,391
2025-03-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$264.27	$26,427	0
2025-03-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,700	$262.97	$447,047	100
2025-03-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,400	$262.03	$890,900	1,800
2025-03-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,906	$261.08	$758,697	5,200
2025-03-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,705	$259.77	$1,741,786	8,106
2025-03-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	8,200	$258.91	$2,123,073	14,811
2025-03-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	13,598	$257.92	$3,507,199	23,011
2025-03-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,500	$256.91	$899,200	36,609
2025-03-06	OYLER JOHN	Chief Executive Officer	Exercise / conversion M	American Depositary Shares	40,109	$6.50	$260,708	40,109
2025-03-06	OYLER JOHN	Chief Executive Officer	Exercise / conversion M	Ordinary Shares	486,161	$0.50	$243,080	4,892,056
2025-03-05	OYLER JOHN	Chief Executive Officer	Equity grant / award A	Ordinary Shares	201,084	$0.00	$0	4,405,895
2025-03-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	323	$257.41	$83,144	0
2025-03-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,809	$256.83	$464,607	323
2025-03-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,214	$255.71	$310,435	2,132
2025-03-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,275	$254.77	$324,836	3,346
2025-03-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	825	$253.55	$209,180	4,621
2025-03-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,000	$252.72	$505,431	5,446
2025-03-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	700	$251.70	$176,193	7,446
2025-03-03	OYLER JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Share Option (Right to Buy)	2,533,531	$0.00	$0	7,566,969
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	600	$249.25	$149,549	0
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,900	$248.63	$969,671	600
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,480	$247.63	$1,604,611	4,500
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,243	$246.57	$1,785,905	10,980
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	19,232	$245.51	$4,721,706	18,223
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,090	$245.36	$267,437	37,455
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	18,386	$244.56	$4,496,442	38,545
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,910	$244.45	$1,200,272	56,931
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	11,195	$243.44	$2,725,326	61,841
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	8,192	$242.46	$1,986,233	73,036
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	13,816	$241.38	$3,334,881	81,228
2025-03-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,956	$240.53	$1,432,605	95,044
2025-03-03	OYLER JOHN	Chief Executive Officer	Exercise / conversion M	American Depositary Shares	101,000	$6.50	$656,500	101,000
2025-03-03	OYLER JOHN	Chief Executive Officer	Exercise / conversion M	Ordinary Shares	1,220,531	$0.50	$610,266	4,199,364
2025-02-28	Wu Xiaobin	President, COO & GM China	Open-market sell S	RMB Shares	0	$0.00	—	0
2025-02-27	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	1,205	$275.00	$331,375	0
2025-02-21	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	400	$260.17	$104,067	0
2025-02-21	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	1,782	$258.73	$461,058	400
2025-02-21	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	437	$258.18	$112,826	2,182
2025-02-21	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	479	$256.70	$122,957	2,619
2025-02-21	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	575	$255.86	$147,117	3,098
2025-02-21	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	1,327	$254.82	$338,149	3,673
2025-02-20	Wu Xiaobin	President, COO & GM China	Exercise / conversion M · derivative	Share Option (Right to Buy)	276,471	$0.00	$0	91,626
2025-02-20	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	21,267	$240.07	$5,105,513	0
2025-02-20	Wu Xiaobin	President, COO & GM China	Exercise / conversion M	American Depositary Shares	21,267	$169.65	$3,607,947	21,267
2025-02-18	Wu Xiaobin	President, COO & GM China	Exercise / conversion M · derivative	Share Option (Right to Buy)	398,502	$0.00	$0	368,097
2025-02-18	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	3,159	$242.08	$764,729	0
2025-02-18	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	7,919	$241.26	$1,910,559	3,159
2025-02-18	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	19,576	$240.31	$4,704,244	11,078
2025-02-18	Wu Xiaobin	President, COO & GM China	Exercise / conversion M	American Depositary Shares	30,654	$169.65	$5,200,451	30,654
2025-02-04	Wang Xiaodong	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	542,880	$0.00	$0	2,171,527
2025-02-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,400	$228.04	$319,259	0
2025-02-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	9,776	$227.00	$2,219,131	1,400
2025-02-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	17,805	$226.35	$4,030,169	11,176
2025-02-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,161	$225.27	$486,805	28,981
2025-02-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,519	$224.18	$340,532	31,142
2025-02-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	9,099	$223.00	$2,029,059	32,661
2025-02-04	Wang Xiaodong	Dir	Exercise / conversion M	American Depositary Shares	41,760	$6.50	$271,440	41,760
2025-01-07	Wang Xiaodong	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	542,880	$0.00	$0	2,714,407
2025-01-07	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,301	$179.18	$233,119	0
2025-01-07	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	5,638	$178.39	$1,005,766	1,301
2025-01-07	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	4,260	$177.42	$755,810	6,939
2025-01-07	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	11,310	$176.67	$1,998,090	11,199
2025-01-07	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	19,251	$175.46	$3,377,728	22,509
2025-01-07	Wang Xiaodong	Dir	Exercise / conversion M	American Depositary Shares	41,760	$6.50	$271,440	41,760
2024-12-14	OYLER JOHN	Chief Executive Officer	Exercise / conversion M · derivative	Share Option (Right to Buy)	1,300,000	$0.00	$0	10,100,500
2024-12-14	OYLER JOHN	Chief Executive Officer	Exercise / conversion M	Ordinary Shares	1,300,000	$0.50	$650,000	2,978,833
2024-12-10	Wang Xiaodong	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	542,880	$0.00	$0	3,257,287
2024-12-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	300	$195.67	$58,700	0
2024-12-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	725	$194.01	$140,655	300
2024-12-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,374	$192.61	$264,641	1,025
2024-12-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	993	$191.78	$190,435	2,399
2024-12-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,833	$190.57	$349,312	3,392
2024-12-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,300	$188.79	$245,428	5,225
2024-12-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	6,350	$187.60	$1,191,280	6,525
2024-12-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	9,266	$186.99	$1,732,647	12,875
2024-12-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	9,956	$185.73	$1,849,167	22,141
2024-12-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	7,063	$184.83	$1,305,473	32,097
2024-12-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,600	$183.60	$477,369	39,160
2024-12-10	Wang Xiaodong	Dir	Exercise / conversion M	American Depositary Shares	41,760	$6.50	$271,440	41,760
2024-12-09	BAKER BROS. ADVISORS LP	—	Open-market sell S	American Depositary Shares	916,964	$186.50	$171,013,786	8,740,387
2024-12-09	BAKER BROS. ADVISORS LP	—	Open-market sell S	American Depositary Shares	83,036	$186.50	$15,486,214	791,493
2024-12-09	BAKER BROS. ADVISORS LP	—	Open-market sell S	American Depositary Shares	33,943	$208.01	$7,060,609	9,657,351
2024-12-09	BAKER BROS. ADVISORS LP	—	Open-market sell S	American Depositary Shares	3,074	$208.01	$639,434	874,529
2024-12-06	Wu Xiaobin	President, COO & GM China	Open-market sell S	RMB Shares	0	$0.00	—	0
2024-12-02	HHLR ADVISORS, LTD.	10%	Open-market sell S	Ordinary Shares	17,842,500	$200.00	$3,568,500,000	125,045,741
2024-11-26	Wang Xiaodong	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	499,993	$0.00	$0	7
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	883	$191.89	$169,436	0
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,725	$191.24	$521,117	883
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,475	$190.31	$280,703	3,608
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	600	$189.03	$113,418	5,083
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,186	$188.08	$223,060	5,683
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,014	$187.15	$189,765	6,869
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	6,981	$191.96	$1,340,087	0
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	407	$191.81	$78,066	6,981
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	12,293	$191.22	$2,350,704	7,388
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	700	$191.05	$133,732	19,681
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	6,187	$190.32	$1,177,517	20,381
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	200	$189.76	$37,952	26,568
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,700	$189.17	$510,748	26,768
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	400	$188.55	$75,419	29,468
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	5,875	$187.98	$1,104,391	29,868
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	300	$187.61	$56,282	35,743
2024-11-26	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	4,425	$187.16	$828,172	36,043
2024-11-26	Wang Xiaodong	Dir	Exercise / conversion M	American Depositary Shares	38,461	$6.50	$249,996	40,468
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,452	$236.37	$343,209	0
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,059	$235.41	$484,715	1,452
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	694	$234.27	$162,585	3,511
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	62	$233.00	$14,446	4,205
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	371	$231.04	$85,718	4,267
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,827	$230.05	$650,350	4,638
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,535	$229.25	$581,139	7,465
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	896	$236.37	$211,787	0
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,272	$235.41	$299,445	896
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	428	$234.27	$100,269	2,168
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	38	$233.00	$8,854	2,596
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	229	$231.05	$52,909	2,634
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,747	$230.05	$401,897	2,863
2024-10-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,565	$229.25	$358,770	4,610
2024-09-30	Sharp Shalini	Dir	Equity grant / award A · derivative	Share Option (Right to Buy)	17,238	$0.00	$0	17,238
2024-09-30	Sharp Shalini	Dir	Equity grant / award A	Ordinary Shares	8,151	$0.00	$0	8,151
2024-09-27	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	5,000	$220.35	$1,101,774	0
2024-09-19	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	4,500	$200.14	$900,615	0
2024-09-17	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	500	$200.00	$100,000	4,500
2024-09-03	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	274	$192.04	$52,620	0
2024-09-03	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	700	$191.20	$133,843	274
2024-09-03	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	2,275	$190.29	$432,909	974
2024-09-03	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	275	$188.97	$51,968	3,249
2024-09-03	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	2,032	$188.16	$382,337	3,524
2024-08-12	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	301,457	$0.00	$0	5,266,973
2024-08-09	Rosenberg Aaron	Chief Financial Officer	Equity grant / award A · derivative	Share Option (Right to Buy)	220,987	$0.00	$0	220,987
2024-08-09	Rosenberg Aaron	Chief Financial Officer	Equity grant / award A	Ordinary Shares	118,547	$0.00	$0	118,547
2024-07-30	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	834	$160.57	$133,915	0
2024-07-01	Wang Julia Aijun	Chief Financial Officer	Open-market sell S	American Depositary Shares	472	$143.90	$67,919	0
2024-06-24	Wang Julia Aijun	Chief Financial Officer	Open-market sell S	American Depositary Shares	899	$155.66	$139,938	0
2024-06-17	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	376	$159.91	$60,127	0
2024-06-17	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	608	$159.40	$96,914	376
2024-06-17	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	297	$158.53	$47,084	984
2024-06-05	Ball Titus B.	Principal Accounting Officer	Equity grant / award A · derivative	Share Option (Right to Buy)	15,340	$0.00	$0	15,340
2024-06-05	Ball Titus B.	Principal Accounting Officer	Equity grant / award A	Ordinary Shares	24,427	$0.00	$0	47,905
2024-04-11	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,811	$147.74	$415,306	0
2024-04-11	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,265	$146.82	$626,170	2,811
2024-04-11	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,008	$146.09	$731,609	7,076
2024-04-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	60	$150.85	$9,051	12,084
2024-04-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,641	$149.79	$395,604	12,144
2024-04-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	12,501	$149.15	$1,864,573	14,785
2024-04-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	11,514	$148.40	$1,708,634	27,286
2024-04-09	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,924	$154.21	$1,221,947	38,800
2024-04-09	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,734	$153.47	$419,592	46,724
2024-04-09	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	542	$152.28	$82,538	49,458
2024-03-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$184.17	$18,417	0
2024-03-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$182.62	$36,525	100
2024-03-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	307	$180.26	$55,339	500
2024-03-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	993	$179.33	$178,072	807
2024-03-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,801	$178.10	$320,757	1,800
2024-03-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,994	$177.11	$1,061,601	3,601
2024-03-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,737	$176.35	$482,663	9,595
2024-03-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$169.05	$33,810	12,332
2024-03-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	733	$166.44	$122,003	12,532
2024-03-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,602	$165.49	$430,599	13,265
2024-03-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	12,069	$164.49	$1,985,202	15,867
2024-03-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	15,466	$163.78	$2,533,011	27,936
2024-03-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,598	$162.74	$1,073,744	43,402
2024-03-11	Glazer Donald W.	Dir	Equity grant / award G	Ordinary Shares	82,020	$0.00	$0	2,702,123
2024-02-29	BRANDICOURT OLIVIER	Dir	Equity grant / award A · derivative	Share Option (Right to Buy)	27,794	$0.00	$0	27,794
2023-11-30	Wang Xiaodong	Dir	Other disposed transaction J	Ordinary Shares	172,372	$0.00	$0	0
2023-11-30	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	71,890	$0.00	$0	5,459,438
2023-11-14	BAKER BROS. ADVISORS LP	Dir	Open-market sell S	American Depositary Shares	1,008,660	$180.50	$182,063,130	9,691,294
2023-11-14	BAKER BROS. ADVISORS LP	Dir	Open-market sell S	American Depositary Shares	91,340	$180.50	$16,486,870	877,603
2023-07-31	Lee Chan Henry	SVP, General Counsel	Open-market sell S	American Depositary Shares	791	$216.26	$171,059	0
2023-07-03	Wang Julia Aijun	Chief Financial Officer	Open-market sell S	American Depositary Shares	472	$179.55	$84,747	0
2023-06-26	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	5	$183.15	$916	0
2023-06-26	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	1,103	$181.91	$200,652	5
2023-06-23	Wang Julia Aijun	Chief Financial Officer	Open-market sell S	American Depositary Shares	840	$182.85	$153,594	0
2023-06-15	Sanders Corazon (Corsee) D.	Dir	Equity grant / award A · derivative	Share Option (Right to Buy)	26,975	$0.00	$0	26,975
2023-06-15	Sanders Corazon (Corsee) D.	Dir	Equity grant / award A	Ordinary Shares	12,922	$0.00	$0	37,414
2023-06-14	HHLR ADVISORS, LTD.	10%	Open-market sell S	Ordinary Shares	273,728	$207.72	$56,857,986	142,888,241
2023-06-13	HHLR ADVISORS, LTD.	10%	Open-market sell S	Ordinary Shares	313,400	$128.43	$40,251,059	143,161,969
2023-06-13	HHLR ADVISORS, LTD.	10%	Open-market sell S	Ordinary Shares	611,000	$211.45	$129,197,294	143,475,369
2023-06-12	HHLR ADVISORS, LTD.	10%	Open-market sell S	Ordinary Shares	968,812	$213.91	$207,240,997	144,086,369
2023-06-12	HHLR ADVISORS, LTD.	10%	Open-market sell S	Ordinary Shares	281,400	$130.83	$36,816,181	145,055,181
2023-06-09	HHLR ADVISORS, LTD.	10%	Open-market sell S	Ordinary Shares	328,952	$217.02	$71,388,604	145,336,581
2023-06-09	HHLR ADVISORS, LTD.	10%	Open-market sell S	Ordinary Shares	213,700	$130.35	$27,856,287	145,665,533
2023-06-08	HHLR ADVISORS, LTD.	10%	Open-market sell S	Ordinary Shares	1,163,825	$218.14	$253,881,790	145,879,233
2023-06-07	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	116	$226.15	$26,234	0
2023-06-07	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	111	$225.27	$25,005	116
2023-06-07	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	161	$224.04	$36,070	227
2023-06-07	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	74	$223.23	$16,519	388
2023-05-08	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	7,000	$253.72	$1,776,037	0
2023-03-16	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	67,444	$0.00	$0	5,445,112
2023-03-08	Wang Xiaodong	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	879,255	$0.00	$0	12
2023-03-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	12,363	$227.78	$2,816,055	0
2023-03-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	17,170	$227.12	$3,899,659	12,363
2023-03-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	14,077	$225.95	$3,180,756	29,533
2023-03-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	200	$226.61	$45,322	43,610
2023-03-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	400	$225.35	$90,139	43,810
2023-03-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	12,534	$224.92	$2,819,196	44,210
2023-03-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	7,458	$224.01	$1,670,658	56,744
2023-03-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	3,433	$223.00	$765,554	64,202
2023-03-08	Wang Xiaodong	Dir	Exercise / conversion M	American Depositary Shares	67,635	$0.13	$8,793	67,635
2023-03-01	Wang Julia Aijun	Chief Financial Officer	Open-market sell S	American Depositary Shares	343	$240.21	$82,392	0
2023-01-12	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	901	$261.48	$235,594	0
2023-01-12	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	4,099	$260.31	$1,066,990	901
2023-01-11	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	100	$254.00	$25,400	0
2023-01-11	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	950	$253.57	$240,889	100
2023-01-11	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,250	$252.22	$315,281	1,050
2023-01-11	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	200	$250.39	$50,077	2,300
2023-01-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,600	$250.09	$400,152	0
2023-01-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	193	$250.26	$48,300	0
2023-01-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,947	$249.84	$486,431	193
2023-01-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	192	$250.26	$48,050	0
2023-01-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,948	$249.84	$486,681	192
2023-01-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,336	$248.76	$332,348	2,140
2023-01-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,442	$247.74	$604,971	3,476
2023-01-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	879	$246.97	$217,083	5,918
2023-01-09	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	900	$250.00	$225,000	0
2022-12-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	92	$225.13	$20,712	0
2022-12-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	91	$225.13	$20,487	0
2022-12-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,625	$224.42	$364,687	92
2022-12-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	366	$224.73	$82,249	0
2022-12-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	367	$224.73	$82,474	0
2022-12-27	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,119	$224.29	$250,984	0
2022-12-27	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,120	$224.29	$251,209	0
2022-12-13	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	665	$212.38	$141,235	0
2022-12-13	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	956	$211.66	$202,347	665
2022-12-13	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,392	$210.59	$293,141	1,621
2022-11-28	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	52,000	$0.00	$0	5,577,556
2022-11-15	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,987	$210.14	$417,541	0
2022-09-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,436	$150.35	$366,260	2,666
2022-09-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,638	$149.21	$393,622	5,102
2022-09-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	450	$153.12	$68,903	0
2022-09-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	500	$152.35	$76,174	450
2022-09-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,716	$151.16	$259,396	950
2022-09-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,435	$150.35	$366,110	2,666
2022-09-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,639	$149.21	$393,771	5,101
2022-09-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,000	$148.25	$296,502	7,740
2022-09-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,412	$153.81	$832,396	100
2022-09-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	9,748	$153.32	$1,494,548	5,512
2022-09-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$154.77	$15,477	0
2022-09-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,411	$153.81	$832,243	100
2022-09-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	9,749	$153.32	$1,494,701	5,511
2022-09-06	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	33,410	$0.00	$0	5,629,556
2022-08-22	Yi Qingqing	Dir	Other disposed transaction J	Ordinary Shares	7,800	$0.00	$0	16,692
2022-08-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	102	$203.59	$20,766	0
2022-08-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,060	$203.15	$215,334	102
2022-08-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	100	$202.05	$20,205	1,162
2022-08-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,824	$201.39	$367,344	1,262
2022-08-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,974	$200.38	$595,945	3,086
2022-08-05	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	968	$195.45	$189,198	800
2022-08-05	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,644	$194.03	$318,979	1,768
2022-08-05	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	888	$193.25	$171,602	3,412
2022-08-05	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	400	$196.57	$78,630	200
2022-08-05	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,000	$195.63	$195,632	600
2022-08-05	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	600	$196.53	$117,915	200
2022-08-05	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,100	$193.70	$406,778	2,200
2022-08-05	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	100	$198.76	$19,876	0
2022-08-05	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	200	$188.87	$37,774	4,500
2022-08-05	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	300	$186.56	$55,968	4,700
2022-07-01	Wang Julia Aijun	Chief Financial Officer	Open-market sell S	American Depositary Shares	317	$158.50	$50,244	0
2022-07-01	Wang Julia Aijun	Chief Financial Officer	Open-market sell S	American Depositary Shares	295	$158.50	$46,758	0
2022-06-27	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	458	$177.32	$81,215	0
2022-06-22	OYLER JOHN	Chief Executive Officer	Equity grant / award A · derivative	Share Option (Right to Buy)	1,887,678	$0.00	$0	1,887,678
2022-06-22	OYLER JOHN	Chief Executive Officer	Equity grant / award A	Ordinary Shares	334,009	$0.00	$0	2,070,913
2022-06-21	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	723	$149.01	$107,734	0
2022-06-17	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	445	$139.40	$62,034	723
2022-06-06	Wang Lai	Global Head of R&D	Open-market sell S	American Depositary Shares	660	$142.00	$93,718	0
2022-05-17	Wang Lai	Global Head of R&D	Exercise / conversion M · derivative	Share Option (Right to Buy)	999,999	$0.00	$0	0
2022-05-17	Wang Lai	Global Head of R&D	Exercise / conversion M · derivative	Share Option (Right to Buy)	233,948	$0.00	$0	0
2022-05-17	Wang Lai	Global Head of R&D	Exercise / conversion M	Ordinary Shares	999,999	$3.49	$3,489,997	1,408,498
2022-05-17	Wang Lai	Global Head of R&D	Exercise / conversion M	Ordinary Shares	233,948	$2.29	$535,741	408,499
2022-05-05	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	500	$169.39	$84,694	0
2022-05-05	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	100	$168.15	$16,814	500
2022-05-05	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	700	$167.32	$117,122	600
2022-05-05	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	1,100	$165.07	$181,578	1,300
2022-05-05	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	175	$165.02	$28,879	2,400
2022-05-05	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	3,350	$163.23	$546,814	2,575
2022-05-05	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	800	$161.72	$129,376	5,925
2022-02-28	Wang Julia Aijun	Chief Financial Officer	Equity grant / award A	Ordinary Shares	61,750	$0.00	$0	143,299
2021-12-15	Wang Lai	Global Head of R&D	Equity grant / award A	RMB Shares	0	$30.13	—	0
2021-12-14	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	211,276
2021-12-14	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$281.63	$56,327	100
2021-12-14	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$284.52	$28,452	0
2021-12-14	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	500	$278.21	$139,106	400
2021-12-14	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$276.95	$83,086	900
2021-12-14	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$119.96	$179,940	1,500
2021-12-01	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	519	$362.45	$188,112	0
2021-12-01	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	530	$357.32	$189,381	519
2021-11-30	Huang Jane	CMO, Hematology	Equity grant / award A	American Depositary Shares	1,049	$0.00	$0	1,049
2021-11-30	Huang Jane	CMO, Hematology	Equity grant / award A	Ordinary Shares	14,820	$0.00	$0	160,055
2021-11-17	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	230,776
2021-11-17	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$385.28	$38,528	300
2021-11-17	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$387.94	$116,382	0
2021-11-17	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$381.41	$76,282	600
2021-11-17	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$119.96	$179,940	1,500
2021-11-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	500	$354.05	$177,026	800
2021-11-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	200	$359.96	$71,993	0
2021-11-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	98	$349.93	$34,293	1,800
2021-11-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	402	$347.71	$139,781	2,598
2021-11-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	700	$348.82	$244,176	1,898
2021-11-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	300	$355.12	$106,537	500
2021-11-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	100	$358.67	$35,867	200
2021-11-08	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	400	$343.10	$137,241	4,100
2021-10-31	Wang Lai	Global Head of R&D	Equity grant / award G	Ordinary Shares	58,188	$0.00	$0	58,188
2021-10-19	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	250,276
2021-10-19	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	400	$375.08	$150,032	300
2021-10-19	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$377.71	$37,771	0
2021-10-19	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$376.36	$75,272	100
2021-10-19	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$119.96	$179,940	1,500
2021-09-28	Wang Lai	Global Head of R&D	Equity grant / award G	Ordinary Shares	58,188	$0.00	$0	174,551
2021-09-24	BeiGene, Ltd.	10%	Open-market buy P	Common Stock	2,543,800	$2.85	$7,249,830	7,348,437
2021-09-20	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	78,000	$0.00	$0	269,776
2021-09-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	150	$407.98	$61,197	200
2021-09-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$406.86	$81,372	350
2021-09-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	583	$401.86	$234,284	550
2021-09-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	400	$400.58	$160,233	1,133
2021-09-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	790	$398.37	$314,709	1,933
2021-09-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	700	$397.15	$278,004	2,723
2021-09-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	913	$395.13	$360,756	4,123
2021-09-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	328	$393.34	$129,016	5,036
2021-09-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	536	$392.40	$210,327	5,364
2021-09-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$411.17	$41,117	0
2021-09-20	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	6,000	$119.96	$719,760	6,000
2021-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$383.00	$76,600	0
2021-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$382.06	$267,438	200
2021-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,000	$379.81	$759,616	900
2021-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,431	$379.02	$2,058,436	2,900
2021-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,515	$377.88	$1,706,117	8,331
2021-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,400	$376.77	$1,281,026	12,846
2021-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,312	$375.60	$1,243,982	16,246
2021-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,600	$374.39	$2,470,957	19,558
2021-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	190,203	$29.31	$5,575,287	1,736,904
2021-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,100	$369.65	$406,615	100
2021-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	10,989	$368.50	$4,049,501	1,200
2021-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,759	$367.52	$1,749,036	12,189
2021-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	13,072	$366.50	$4,790,880	16,948
2021-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,657	$365.68	$2,068,662	30,020
2021-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,400	$364.23	$509,918	35,677
2021-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$362.81	$253,965	37,077
2021-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$370.48	$37,048	0
2021-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	157,600	$28.22	$4,447,078	2,267,161
2021-09-13	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1	$363.45	$363	0
2021-09-13	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,581	$362.80	$573,583	1
2021-09-13	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	900	$361.05	$324,945	1,582
2021-09-13	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,800	$359.88	$647,789	2,482
2021-09-13	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,700	$359.15	$610,552	4,282
2021-09-13	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,300	$357.54	$464,808	5,982
2021-09-13	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,400	$356.46	$499,040	7,282
2021-09-13	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	4,219	$355.37	$1,499,309	8,682
2021-09-10	AMGEN INC	10%	Open-market buy P	American Depositary Shares	165,529	$302.06	$49,999,938	18,943,802
2021-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	320	$332.75	$106,480	0
2021-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,565	$332.05	$1,847,834	320
2021-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,100	$330.82	$694,723	5,885
2021-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,500	$329.79	$824,478	7,985
2021-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	800	$328.70	$262,960	10,485
2021-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,176	$327.28	$712,159	11,285
2021-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,810	$326.43	$1,243,713	13,461
2021-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,828	$325.56	$920,673	17,271
2021-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,400	$324.50	$1,427,787	20,099
2021-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,705	$327.50	$2,195,856	0
2021-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,772	$326.48	$1,231,466	6,705
2021-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,600	$325.55	$1,497,507	10,477
2021-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	10,424	$324.41	$3,381,655	15,077
2021-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	400	$24.71	$9,884	2,917,162
2021-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	127,158	$24.34	$3,095,280	3,567,562
2021-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,701	$307.75	$1,754,479	0
2021-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,596	$306.82	$489,689	5,701
2021-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,404	$305.69	$1,040,566	7,297
2021-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,300	$304.69	$1,005,488	10,701
2021-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,858	$303.65	$1,475,155	14,001
2021-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,624	$302.50	$1,398,769	18,859
2021-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,856	$301.68	$1,464,968	23,483
2021-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,242	$300.68	$1,576,178	28,339
2021-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$299.74	$209,819	33,581
2021-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	76,800	$23.67	$1,817,756	3,694,720
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	30	$343.48	$10,304	600
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	970	$342.85	$332,564	630
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	969	$341.67	$331,083	1,600
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	702	$340.19	$238,813	2,569
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	406	$339.15	$137,695	3,271
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	505	$338.36	$170,872	3,677
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	600	$344.58	$206,746	0
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,009	$335.65	$674,321	5,582
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	900	$335.37	$301,833	7,591
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	371	$334.10	$123,950	8,491
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	800	$336.29	$269,036	4,782
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$331.64	$232,145	9,662
2021-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	34,100	$25.82	$880,302	4,217,173
2021-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$348.12	$34,812	0
2021-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,756	$347.45	$957,572	100
2021-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,800	$346.44	$1,316,470	2,856
2021-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,686	$345.55	$1,273,697	6,656
2021-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,909	$344.38	$1,001,814	10,342
2021-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	8,104	$343.32	$2,782,245	13,251
2021-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	10,092	$342.49	$3,456,380	21,355
2021-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$340.39	$102,118	31,447
2021-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	49,100	$26.08	$1,280,479	4,385,979
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,800	$341.10	$1,978,380	0
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	12,088	$340.96	$4,121,506	5,800
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,600	$340.02	$884,061	17,888
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,300	$339.97	$1,121,895	20,488
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,200	$338.77	$745,285	24,488
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,900	$337.47	$641,198	26,688
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$337.16	$33,716	28,588
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,447	$336.70	$1,160,606	28,688
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,024	$335.65	$679,358	32,135
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,000	$333.01	$333,013	34,759
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$329.66	$65,931	36,759
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$338.86	$237,199	23,788
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,100	$324.70	$1,006,578	38,259
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	600	$334.22	$200,530	34,159
2021-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	41,400	$25.17	$1,041,881	4,847,790
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	516	$322.17	$166,241	0
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,589	$321.16	$1,152,653	516
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,000	$320.27	$640,541	4,105
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$319.01	$63,802	6,105
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,100	$317.65	$349,412	6,305
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,000	$316.16	$316,157	7,405
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	400	$314.55	$125,819	8,405
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	811	$313.56	$254,297	8,805
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	800	$312.25	$249,804	9,616
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	500	$311.44	$155,721	10,416
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$309.86	$92,958	10,916
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$308.86	$30,886	11,216
2021-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	57,900	$23.71	$1,373,070	5,434,657
2021-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$313.36	$94,007	0
2021-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,100	$312.28	$343,508	300
2021-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,610	$311.19	$501,024	1,400
2021-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,200	$310.05	$372,057	3,010
2021-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,407	$309.01	$434,774	4,210
2021-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,193	$308.11	$983,786	5,617
2021-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,150	$307.04	$1,581,238	8,810
2021-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	500	$306.04	$153,020	13,960
2021-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	800	$304.93	$243,942	14,460
2021-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	11,900	$24.58	$292,466	5,639,665
2021-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,505	$322.08	$484,731	0
2021-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,400	$321.18	$449,653	1,505
2021-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,900	$320.05	$608,088	2,905
2021-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,100	$318.88	$988,526	4,805
2021-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,300	$318.20	$731,868	7,905
2021-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,790	$316.85	$1,834,548	10,205
2021-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	27,700	$24.61	$681,642	5,849,945
2021-07-15	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	68,315	$0.00	$0	204,971
2021-07-15	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	114,803	$0.00	$0	347,776
2021-07-15	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	89,882	$0.00	$0	122,798
2021-07-15	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	98	$335.76	$32,904	0
2021-07-15	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,000	$334.85	$334,846	98
2021-07-15	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	2,823	$333.64	$941,861	1,098
2021-07-15	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	8,177	$332.71	$2,720,587	3,921
2021-07-15	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	6,523	$331.79	$2,164,250	12,098
2021-07-15	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	2,379	$330.53	$786,322	18,621
2021-07-15	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	5,255	$174.43	$916,630	21,000
2021-07-15	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	8,831	$119.96	$1,059,367	15,745
2021-07-15	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	6,914	$160.40	$1,109,006	6,914
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3	$324.98	$975	0
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	800	$324.38	$259,506	3
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$322.92	$64,583	803
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	900	$322.08	$289,874	1,003
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,500	$321.15	$802,873	1,903
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,524	$320.20	$1,448,591	4,403
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,100	$319.43	$351,374	8,927
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$318.03	$95,410	10,027
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	945	$316.79	$299,364	10,327
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$315.64	$220,949	11,272
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,309	$314.53	$411,716	11,972
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,600	$313.23	$501,163	13,281
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	600	$312.31	$187,384	14,881
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	400	$310.64	$124,254	15,481
2021-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	51,300	$24.24	$1,243,717	6,085,580
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	857	$323.71	$277,420	300
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$322.63	$96,789	1,157
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,100	$319.59	$351,548	2,657
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,673	$318.53	$532,900	3,757
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,804	$317.38	$572,559	5,430
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,137	$315.18	$988,734	9,634
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,100	$314.50	$974,960	12,771
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,200	$313.38	$1,002,826	15,871
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,675	$312.13	$1,147,073	19,071
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,400	$316.43	$759,438	7,234
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	900	$320.52	$288,470	1,757
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	40,700	$25.14	$1,023,247	6,343,333
2021-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$325.23	$97,570	0
2021-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$332.26	$33,226	0
2021-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$328.07	$229,646	200
2021-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,290	$327.22	$749,337	900
2021-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,015	$326.28	$983,723	3,190
2021-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	885	$325.01	$287,634	6,205
2021-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,023	$323.63	$654,710	7,090
2021-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,062	$322.93	$988,799	9,113
2021-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	900	$321.72	$289,550	12,175
2021-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	Ordinary Shares	44,300	$25.42	$1,126,048	6,722,631
2021-07-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,211	$349.89	$423,714	300
2021-07-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,500	$348.64	$522,962	1,511
2021-07-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,100	$347.31	$382,046	3,011
2021-07-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	437	$345.88	$151,151	4,111
2021-07-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	300	$350.59	$105,176	0
2021-06-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	207,575
2021-06-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$356.98	$71,395	0
2021-06-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	400	$351.06	$140,425	700
2021-06-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$349.22	$34,922	1,100
2021-06-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$355.26	$106,578	200
2021-06-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2021-06-28	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	425	$365.00	$155,125	0
2021-06-18	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	486	$325.89	$158,383	0
2021-06-16	Yi Qingqing	Dir	Equity grant / award A · derivative	Share Option (Right to Buy)	17,498	$0.00	$0	17,498
2021-06-16	Yi Qingqing	Dir	Equity grant / award A	Ordinary Shares	7,800	$0.00	$0	7,800
2021-06-10	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	36,868	$0.00	$0	188,926
2021-06-10	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	305	$353.69	$107,875	0
2021-06-10	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	1,339	$352.74	$472,315	305
2021-06-10	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	508	$351.79	$178,707	1,644
2021-06-10	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	684	$350.08	$239,452	2,152
2021-06-10	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M	American Depositary Shares	2,836	$31.59	$89,589	2,836
2021-06-09	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	41,132	$0.00	$0	225,794
2021-06-09	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	600	$352.74	$211,642	0
2021-06-09	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	1,201	$351.70	$422,389	600
2021-06-09	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	1,363	$350.43	$477,638	1,801
2021-06-09	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M	American Depositary Shares	3,164	$31.59	$99,951	3,164
2021-06-07	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	2	$351.53	$703	0
2021-06-07	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	571	$353.57	$201,888	2
2021-06-07	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	2,825	$352.33	$995,326	573
2021-06-03	Glazer Donald W.	Dir	Equity grant / award G	Ordinary Shares	7,400	$0.00	$0	2,746,729
2021-06-01	Glazer Donald W.	Dir	Equity grant / award G	Ordinary Shares	69,000	$0.00	$0	2,754,129
2021-06-01	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	540	$362.64	$195,828	0
2021-05-31	Huang Jane	CMO, Hematology	Equity grant / award A	American Depositary Shares	540	$0.00	$0	540
2021-05-31	Huang Jane	CMO, Hematology	Equity grant / award A	Ordinary Shares	7,189	$0.00	$0	292,772
2021-05-28	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	227,075
2021-05-28	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	147	$358.36	$52,679	100
2021-05-28	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	353	$357.50	$126,197	247
2021-05-28	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$356.21	$106,863	600
2021-05-28	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	500	$354.97	$177,487	900
2021-05-28	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$359.42	$35,942	0
2021-05-28	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2021-05-27	Glazer Donald W.	Dir	Equity grant / award G	Ordinary Shares	4,700	$0.00	$0	2,823,129
2021-05-10	Wang Xiaodong	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	88,231	$0.00	$0	4
2021-05-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	389	$303.10	$117,906	0
2021-05-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	311	$302.21	$93,988	389
2021-05-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,594	$300.20	$478,518	700
2021-05-10	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,100	$299.40	$329,340	2,294
2021-05-10	Wang Xiaodong	Dir	Exercise / conversion M	American Depositary Shares	3,394	$0.13	$441	3,394
2021-05-10	Wang Xiaodong	Dir	Exercise / conversion M	Ordinary Shares	44,109	$0.13	$5,734	5,747,271
2021-05-03	Wu Xiaobin	President, COO & GM China	Open-market sell S	American Depositary Shares	6,715	$343.00	$2,303,245	0
2021-04-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	246,575
2021-04-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	400	$355.12	$142,046	500
2021-04-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$356.25	$106,876	200
2021-04-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$358.62	$71,724	0
2021-04-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$350.25	$35,025	1,400
2021-04-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2021-03-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	266,075
2021-03-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	227	$326.29	$74,067	0
2021-03-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$325.56	$65,112	227
2021-03-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	378	$324.14	$122,525	427
2021-03-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	395	$323.31	$127,706	805
2021-03-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$321.94	$96,582	1,200
2021-03-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2021-03-12	Glazer Donald W.	Dir	Equity grant / award G	Ordinary Shares	80,000	$0.00	$0	2,827,829
2021-02-26	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	285,575
2021-02-26	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	600	$322.33	$193,398	0
2021-02-26	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	400	$321.21	$128,485	600
2021-02-26	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$319.67	$95,902	1,000
2021-02-26	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$317.52	$31,752	1,300
2021-02-26	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2021-01-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	305,075
2021-01-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$331.46	$66,292	0
2021-01-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$330.05	$33,005	200
2021-01-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	7	$320.81	$2,246	800
2021-01-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	393	$319.61	$125,607	807
2021-01-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$322.51	$96,754	500
2021-01-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2021-01-15	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	163,800	$0.00	$0	649,000
2021-01-15	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	5,606	$345.54	$1,937,087	0
2021-01-15	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	6,994	$344.38	$2,408,602	5,606
2021-01-15	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M	American Depositary Shares	12,600	$6.50	$81,900	12,600
2021-01-14	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	18,200	$0.00	$0	812,800
2021-01-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	300	$345.15	$103,546	0
2021-01-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	1,100	$344.28	$378,710	300
2021-01-14	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M	American Depositary Shares	1,400	$6.50	$9,100	1,400
2021-01-04	BAKER BROS. ADVISORS LP	Dir	Open-market sell S	American Depositary Shares	111,094	$220.50	$24,496,227	10,699,954
2021-01-04	BAKER BROS. ADVISORS LP	Dir	Open-market sell S	American Depositary Shares	10,060	$220.50	$2,218,230	968,943
2020-12-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	324,575
2020-12-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$252.86	$75,859	0
2020-12-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$249.88	$49,975	600
2020-12-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2020-12-18	AMGEN INC	10%	Equity grant / award A	American Depositary Shares	25,762	$260.95	$6,722,504	18,778,273
2020-12-17	AMGEN INC	10%	Equity grant / award A	American Depositary Shares	74,624	$260.54	$19,442,507	18,752,511
2020-12-16	AMGEN INC	10%	Equity grant / award A	American Depositary Shares	85,573	$248.26	$21,244,456	18,677,887
2020-12-15	AMGEN INC	10%	Equity grant / award A	American Depositary Shares	67,941	$239.31	$16,258,723	18,592,314
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,600,000	$0.00	$0	831,000
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	700	$232.19	$162,532	0
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	17,456	$231.11	$4,034,303	700
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	24,842	$230.51	$5,726,245	18,156
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	9,752	$229.18	$2,234,962	42,998
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	5,885	$228.23	$1,343,126	52,750
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	400	$228.10	$91,240	58,635
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	7,500	$227.72	$1,707,920	59,035
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	15,062	$227.08	$3,420,268	66,535
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	6,203	$226.40	$1,404,377	81,597
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	4,100	$225.24	$923,480	87,800
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M	American Depositary Shares	91,900	$6.50	$597,350	91,900
2020-12-14	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M	Ordinary Shares	1,405,300	$0.50	$702,650	1,573,715
2020-12-11	OYLER JOHN	Chief Executive Officer	Equity grant / award G	Ordinary Shares	545,597	$0.00	$0	545,597
2020-12-11	OYLER JOHN	Chief Executive Officer	Equity grant / award G	Ordinary Shares	1,591,317	$0.00	$0	7,336,253
2020-12-10	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	1,244,542	$0.00	$0	1,244,542
2020-12-10	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	88,010	$0.00	$0	7,112,999
2020-12-04	Glazer Donald W.	Dir	Equity grant / award G	Ordinary Shares	589,849	$0.00	$0	2,907,829
2020-11-30	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	344,075
2020-11-30	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	96	$285.05	$27,365	0
2020-11-30	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$266.75	$80,025	496
2020-11-30	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$264.50	$52,900	796
2020-11-30	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$278.92	$27,892	96
2020-11-30	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	104	$256.00	$26,624	1,396
2020-11-30	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2020-10-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	363,575
2020-10-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$301.51	$30,151	0
2020-10-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	139	$300.70	$41,798	100
2020-10-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,261	$299.88	$378,144	239
2020-10-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2020-10-16	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	5,000	$320.00	$1,600,000	0
2020-10-05	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	5,000	$300.00	$1,500,000	0
2020-09-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,609	$283.11	$455,527	400
2020-09-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,236	$282.05	$1,194,760	2,009
2020-09-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	10,827	$281.16	$3,044,160	6,245
2020-09-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,831	$280.30	$1,073,814	17,072
2020-09-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	800	$278.92	$223,136	20,903
2020-09-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	400	$283.80	$113,521	0
2020-09-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$274.42	$54,884	22,103
2020-09-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	550	$274.08	$150,744	22,303
2020-09-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	450	$272.74	$122,731	22,853
2020-09-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	383,075
2020-09-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	102	$283.83	$28,950	0
2020-09-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	468	$281.75	$131,859	102
2020-09-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	730	$280.65	$204,875	570
2020-09-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$274.42	$54,884	1,300
2020-09-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2020-09-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$282.87	$198,010	0
2020-09-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,800	$281.04	$505,874	700
2020-09-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	21,080	$280.26	$5,907,883	2,500
2020-09-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,187	$279.24	$1,448,396	23,580
2020-09-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,233	$278.50	$621,901	28,767
2020-09-25	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	620	$281.34	$174,433	0
2020-09-25	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	4,380	$280.29	$1,227,683	620
2020-09-17	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	84	$261.12	$21,934	0
2020-09-17	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	4,916	$260.26	$1,279,421	84
2020-09-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	723	$257.97	$186,513	0
2020-09-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$256.86	$77,057	723
2020-09-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,800	$255.88	$716,476	1,023
2020-09-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	13,140	$255.14	$3,352,505	3,823
2020-09-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	10,312	$253.71	$2,616,255	16,963
2020-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	266	$257.87	$68,593	0
2020-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,100	$256.82	$282,506	266
2020-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,642	$255.64	$1,186,671	1,366
2020-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	12,799	$254.95	$3,263,158	6,008
2020-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,339	$253.80	$1,355,033	18,807
2020-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,868	$252.97	$1,990,352	24,146
2020-09-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,200	$251.39	$553,068	32,014
2020-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	170	$252.53	$42,930	0
2020-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,476	$251.90	$875,606	170
2020-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,877	$250.56	$1,723,095	3,646
2020-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,116	$249.73	$1,777,102	10,523
2020-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,500	$248.56	$372,842	17,639
2020-09-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	600	$247.01	$148,206	19,139
2020-09-03	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	217	$235.21	$51,041	0
2020-09-03	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	500	$234.17	$117,085	217
2020-09-03	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,411	$232.94	$328,672	717
2020-09-03	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,000	$232.25	$232,247	2,128
2020-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,016	$234.78	$473,308	0
2020-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,018	$234.28	$707,062	2,016
2020-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,455	$232.70	$338,578	5,034
2020-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,905	$231.52	$441,046	6,489
2020-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,300	$230.50	$760,641	8,394
2020-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	610	$228.92	$139,643	11,694
2020-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,802	$228.08	$410,995	12,304
2020-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	8,019	$226.97	$1,820,064	14,106
2020-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,482	$226.07	$1,013,258	22,125
2020-09-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,200	$224.52	$269,428	26,607
2020-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	900	$239.63	$215,665	0
2020-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,000	$238.46	$238,461	900
2020-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	647	$237.27	$153,511	1,900
2020-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,904	$236.12	$449,580	2,547
2020-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,228	$234.98	$288,555	4,451
2020-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,290	$234.28	$1,005,045	5,679
2020-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,401	$232.86	$791,969	9,969
2020-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,959	$231.92	$686,250	13,370
2020-09-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,945	$230.87	$910,773	16,329
2020-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	42	$242.81	$10,198	0
2020-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,312	$242.15	$802,017	42
2020-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,707	$241.14	$1,376,172	3,354
2020-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,200	$240.15	$528,326	9,061
2020-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	600	$239.09	$143,452	11,261
2020-08-31	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,100	$237.82	$261,599	11,861
2020-08-28	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	39,000	$0.00	$0	402,575
2020-08-28	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$244.93	$73,478	0
2020-08-28	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	700	$243.49	$170,442	300
2020-08-28	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,000	$242.41	$242,413	1,000
2020-08-28	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$240.86	$48,172	2,000
2020-08-28	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	800	$240.15	$192,121	2,200
2020-08-28	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	3,000	$29.49	$88,470	3,000
2020-08-25	AMGEN INC	10%	Equity grant / award A	American Depositary Shares	59,390	$248.49	$14,757,578	18,524,373
2020-08-24	Sanders Corazon (Corsee) D.	Dir	Equity grant / award A · derivative	Share Option (Right to Buy)	27,482	$0.00	$0	27,482
2020-08-24	AMGEN INC	10%	Equity grant / award A	American Depositary Shares	59,390	$239.10	$14,199,906	18,464,983
2020-08-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	694	$243.48	$168,976	0
2020-08-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,700	$242.96	$1,627,837	694
2020-08-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,471	$241.62	$597,033	7,394
2020-08-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,255	$240.64	$1,505,215	9,865
2020-08-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	10,997	$239.66	$2,635,540	16,120
2020-08-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	10,568	$238.86	$2,524,293	27,117
2020-08-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,103	$237.80	$737,882	37,685
2020-08-21	AMGEN INC	10%	Equity grant / award A	American Depositary Shares	64,176	$230.18	$14,772,012	18,405,593
2020-08-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,679	$237.44	$1,110,972	0
2020-08-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,101	$236.50	$496,879	4,679
2020-08-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,845	$235.22	$904,411	6,780
2020-08-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,798	$234.45	$1,124,895	10,625
2020-08-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	600	$233.13	$139,875	15,423
2020-08-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,000	$232.34	$464,678	16,023
2020-08-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,500	$231.15	$577,881	18,023
2020-08-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,000	$230.16	$230,158	20,523
2020-08-20	AMGEN INC	10%	Equity grant / award A	American Depositary Shares	64,176	$234.99	$15,080,981	18,341,417
2020-08-19	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,300	$237.04	$308,155	0
2020-08-19	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,800	$236.32	$1,134,328	1,300
2020-08-19	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,221	$235.23	$1,463,352	6,100
2020-08-19	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	9,741	$234.24	$2,281,767	12,321
2020-08-19	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,403	$233.35	$1,027,421	22,062
2020-08-19	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,401	$232.36	$790,243	26,465
2020-08-19	AMGEN INC	10%	Equity grant / award A	American Depositary Shares	64,176	$234.88	$15,073,454	18,277,241
2020-08-18	AMGEN INC	10%	Equity grant / award A	American Depositary Shares	40,000	$230.18	$9,207,188	18,213,065
2020-08-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$214.06	$64,219	0
2020-08-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,500	$212.99	$319,484	300
2020-08-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,790	$211.63	$378,825	1,800
2020-08-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,817	$210.84	$593,949	3,590
2020-08-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,298	$209.55	$481,556	6,407
2020-08-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,903	$216.10	$411,246	0
2020-08-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,585	$215.30	$1,202,464	1,903
2020-08-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,743	$214.44	$802,654	7,488
2020-08-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	800	$213.56	$170,846	11,231
2020-08-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,731	$211.93	$366,854	12,031
2020-08-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	681	$211.01	$143,697	13,762
2020-08-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,200	$214.00	$256,803	0
2020-08-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,482	$213.36	$1,596,382	1,200
2020-08-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,322	$212.38	$493,141	8,682
2020-08-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,701	$211.43	$782,499	11,004
2020-08-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,015	$210.37	$844,622	14,705
2020-08-12	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,100	$209.38	$230,319	18,720
2020-08-12	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	37,661	$0.00	$0	266,926
2020-08-12	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	2,897	$212.00	$614,165	0
2020-08-12	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M	American Depositary Shares	2,897	$31.59	$91,516	2,897
2020-08-11	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	24,739	$0.00	$0	304,587
2020-08-11	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	203	$214.23	$43,489	0
2020-08-11	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	700	$213.59	$149,513	203
2020-08-11	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	1,000	$212.41	$212,407	903
2020-08-11	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M	American Depositary Shares	1,903	$31.59	$60,116	1,903
2020-08-10	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	28,600	$0.00	$0	329,326
2020-08-10	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	300	$216.57	$64,971	0
2020-08-10	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	500	$214.66	$107,332	600
2020-08-10	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	400	$213.25	$85,301	1,100
2020-08-10	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	700	$212.34	$148,641	1,500
2020-08-10	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M	American Depositary Shares	2,200	$31.59	$69,498	2,200
2020-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	621	$227.00	$140,970	0
2020-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,767	$226.21	$852,136	621
2020-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	608	$225.36	$137,017	4,388
2020-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,894	$224.28	$424,787	4,996
2020-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,365	$223.32	$528,160	6,890
2020-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,399	$222.16	$532,961	9,255
2020-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,600	$221.32	$796,769	11,654
2020-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,300	$220.16	$286,202	15,254
2020-08-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$218.96	$153,272	16,554
2020-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$226.00	$22,600	0
2020-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$225.02	$67,507	100
2020-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	301	$224.05	$67,439	400
2020-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,921	$222.62	$427,652	701
2020-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,300	$221.85	$732,101	2,622
2020-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,209	$220.62	$487,360	5,922
2020-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,575	$219.56	$565,373	8,131
2020-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,025	$218.69	$661,546	10,706
2020-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,369	$217.73	$298,068	13,731
2020-08-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	283	$216.63	$61,305	15,100
2020-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$225.08	$67,524	0
2020-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,400	$224.23	$538,150	300
2020-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,107	$223.46	$694,301	2,700
2020-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,567	$222.14	$792,383	5,807
2020-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	12,020	$221.43	$2,661,547	9,374
2020-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,876	$220.42	$633,920	21,394
2020-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	206	$219.22	$45,160	24,270
2020-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$216.72	$43,343	24,476
2020-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	400	$214.99	$85,995	24,676
2020-08-03	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$212.53	$21,253	25,076
2020-07-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	212,680
2020-07-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	399	$213.56	$85,210	0
2020-07-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	400	$212.53	$85,011	399
2020-07-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$211.31	$42,262	799
2020-07-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	700	$208.91	$146,237	999
2020-07-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,301	$208.35	$271,067	1,699
2020-07-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$160.40	$240,600	3,000
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$248.00	$24,800	0
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	354	$246.99	$87,434	100
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	146	$245.78	$35,884	454
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$244.63	$73,389	600
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,000	$243.35	$243,355	900
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,900	$242.62	$460,985	1,900
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,505	$241.40	$363,307	3,800
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,795	$240.27	$431,284	5,305
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,400	$239.45	$574,674	7,100
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,300	$238.54	$787,182	9,500
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,612	$237.61	$1,095,876	12,800
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,200	$236.14	$991,788	17,412
2020-07-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,136	$235.26	$1,443,546	21,612
2020-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,300	$255.53	$332,195	0
2020-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,594	$254.29	$913,914	1,300
2020-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,500	$253.60	$1,141,184	4,894
2020-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,896	$252.34	$983,119	9,394
2020-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,751	$251.62	$1,447,074	13,290
2020-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,612	$250.49	$403,790	19,041
2020-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,350	$249.05	$336,219	20,653
2020-07-21	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,410	$248.12	$1,094,201	22,003
2020-07-20	Wu Xiaobin	President & GM China	Open-market sell S	American Depositary Shares	2,600	$250.16	$650,407	0
2020-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$254.23	$50,846	0
2020-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,948	$253.67	$1,762,528	200
2020-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,345	$252.56	$1,855,061	7,148
2020-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,032	$251.41	$1,013,704	14,493
2020-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,326	$250.51	$1,835,211	18,525
2020-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,211	$249.82	$552,344	25,851
2020-07-20	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$248.70	$174,088	28,062
2020-07-17	Wu Xiaobin	President & GM China	Open-market sell S	American Depositary Shares	400	$250.04	$100,015	0
2020-07-17	Wu Xiaobin	President & GM China	Open-market sell S	American Depositary Shares	300	$240.00	$72,000	400
2020-07-15	Wu Xiaobin	President & GM China	Open-market sell S	American Depositary Shares	200	$246.10	$49,220	0
2020-07-15	Wu Xiaobin	President & GM China	Open-market sell S	American Depositary Shares	300	$242.63	$72,789	400
2020-07-15	Wu Xiaobin	President & GM China	Open-market sell S	American Depositary Shares	2,000	$240.10	$480,208	700
2020-07-15	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Ordinary Shares	13,589,904	$14.23	$193,395,206	18,840,379
2020-07-15	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A	Ordinary Shares	994,276	$14.23	$14,149,343	1,021,851
2020-07-13	Wu Xiaobin	President & GM China	Open-market sell S	American Depositary Shares	3,000	$220.00	$660,000	0
2020-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,854	$203.81	$581,680	0
2020-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,834	$202.37	$775,895	2,854
2020-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,841	$201.58	$975,869	6,688
2020-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,900	$200.55	$581,597	11,529
2020-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,800	$199.26	$358,672	14,429
2020-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$197.98	$138,585	16,229
2020-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	600	$196.51	$117,908	16,929
2020-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	8,318	$199.88	$1,662,567	0
2020-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,474	$199.01	$1,089,391	8,318
2020-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,501	$197.80	$296,903	13,792
2020-07-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,730	$196.82	$734,126	15,293
2020-07-07	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	6,000	$200.00	$1,200,000	0
2020-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,561	$198.32	$507,901	0
2020-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,300	$197.43	$1,243,810	2,561
2020-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,701	$196.62	$1,514,204	8,861
2020-07-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	800	$195.43	$156,347	16,562
2020-07-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,800	$192.08	$345,752	0
2020-07-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,016	$191.10	$385,265	1,800
2020-07-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	457	$192.31	$87,887	0
2020-07-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,600	$191.37	$306,184	457
2020-07-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,100	$190.46	$399,957	2,057
2020-07-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	690	$189.19	$130,544	4,157
2020-06-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	461,075
2020-06-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$193.56	$19,356	0
2020-06-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	198	$192.72	$38,158	100
2020-06-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	500	$191.37	$95,685	298
2020-06-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	402	$188.95	$75,959	798
2020-06-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$187.91	$56,373	1,200
2020-06-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2020-06-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	435	$192.46	$83,720	0
2020-06-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	35	$193.68	$6,779	0
2020-06-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,100	$192.84	$212,128	35
2020-06-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$191.56	$57,468	1,135
2020-06-26	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	27,027	$0.00	$0	283,153
2020-06-26	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	700	$200.30	$140,208	0
2020-06-26	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	679	$200.27	$135,985	1,400
2020-06-26	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	2,079	$160.40	$333,472	2,079
2020-06-24	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,725	$189.42	$326,745	0
2020-06-24	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,800	$188.20	$715,163	1,725
2020-06-24	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,115	$187.10	$769,914	5,525
2020-06-24	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,741	$186.11	$882,334	9,640
2020-06-23	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	410	$188.43	$77,258	14,381
2020-06-23	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,438	$187.46	$1,394,335	14,791
2020-06-23	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,922	$186.63	$918,569	22,229
2020-06-23	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,610	$185.54	$298,712	27,151
2020-06-23	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	690	$184.56	$127,348	28,761
2020-06-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,095	$183.72	$568,601	29,451
2020-06-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,714	$182.78	$678,839	32,546
2020-06-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,772	$181.79	$322,138	36,260
2020-06-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	800	$180.50	$144,401	38,032
2020-06-22	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	900	$179.58	$161,626	38,832
2020-06-17	BAKER BROS. ADVISORS LP	Dir	Equity grant / award A · derivative	Share Option (Right to Buy)	90,766	$0.00	$0	90,766
2020-06-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	900	$175.07	$157,563	0
2020-06-08	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	453	$170.84	$77,391	0
2020-05-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	480,575
2020-05-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	431	$165.12	$71,168	0
2020-05-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	569	$163.97	$93,300	431
2020-05-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	500	$162.63	$81,316	1,000
2020-05-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2020-05-19	Glazer Donald W.	Dir	Open-market sell S	American Depositary Shares	10,000	$169.84	$1,698,400	0
2020-05-19	Glazer Donald W.	Dir	Equity grant / award G	Ordinary Shares	2,680	$0.00	$0	3,497,678
2020-05-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	474	$141.00	$66,834	0
2020-05-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,859	$140.96	$403,005	474
2020-05-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	302	$143.17	$43,237	3,333
2020-05-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,000	$142.46	$142,462	3,635
2020-04-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	500,075
2020-04-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,500	$162.30	$243,450	0
2020-04-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2020-04-16	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	519,575
2020-04-16	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,500	$160.00	$240,000	0
2020-04-16	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2020-03-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	201	$158.63	$31,884	0
2020-03-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,768	$157.51	$278,476	201
2020-03-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	3,031	$156.82	$475,321	1,969
2020-03-03	HOOPER ANTHONY C	Dir	Equity grant / award A · derivative	Share Option (Right to Buy)	21,970	$0.00	$0	21,970
2020-02-18	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	539,075
2020-02-18	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	321	$171.14	$54,935	0
2020-02-18	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,179	$170.01	$200,445	321
2020-02-18	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2020-01-21	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	558,575
2020-01-21	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	87	$172.34	$14,994	0
2020-01-21	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	600	$171.27	$102,762	87
2020-01-21	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	813	$170.09	$138,287	687
2020-01-21	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2019-12-17	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,958	$165.61	$324,263	0
2019-12-17	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$163.20	$32,640	1,958
2019-12-17	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,400	$162.42	$389,796	2,158
2019-12-17	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	18,215	$161.49	$2,941,528	4,558
2019-12-17	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	16,965	$160.60	$2,724,572	22,773
2019-12-17	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	15,466	$159.59	$2,468,196	39,738
2019-12-17	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,055	$158.63	$1,119,105	55,204
2019-12-16	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	578,075
2019-12-16	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$170.72	$34,145	200
2019-12-16	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	800	$161.93	$129,541	600
2019-12-16	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	100	$173.59	$17,359	0
2019-12-16	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.49	$44,235	1,500
2019-11-20	Glazer Donald W.	Dir	Equity grant / award G	Ordinary Shares	81,060	$0.00	$0	3,630,366
2019-11-18	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	325,000	$0.00	$0	3,795,000
2019-11-18	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	400	$198.93	$79,572	0
2019-11-18	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	200	$197.55	$39,510	400
2019-11-18	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	5,633	$195.57	$1,101,671	800
2019-11-18	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	8,156	$194.62	$1,587,311	6,433
2019-11-18	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	6,944	$193.60	$1,344,334	14,589
2019-11-18	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	2,311	$192.63	$445,168	21,533
2019-11-18	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	1,156	$191.80	$221,724	23,844
2019-11-18	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M	American Depositary Shares	25,000	$6.50	$162,500	25,000
2019-11-15	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	395	$202.05	$79,810	0
2019-11-15	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,496	$202.05	$302,267	0
2019-11-15	Wu Xiaobin	President & GM China	Open-market sell S	American Depositary Shares	1,000	$202.05	$202,050	0
2019-11-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,605	$193.57	$504,242	395
2019-11-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	100	$196.87	$19,687	1,496
2019-11-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	300	$195.86	$58,757	1,596
2019-11-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,900	$195.14	$370,774	1,896
2019-11-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	704	$194.12	$136,662	3,796
2019-11-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,200	$193.04	$424,692	4,500
2019-11-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,500	$192.19	$480,482	6,700
2019-11-14	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	800	$191.03	$152,826	9,200
2019-11-13	Wang Xiaodong	Dir	Equity grant / award A	Ordinary Shares	50	$0.00	$0	50
2019-11-13	Wang Xiaodong	Dir	Other disposed transaction J	Ordinary Shares	50	$0.00	$0	4,903,998
2019-11-04	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,000	$190.00	$190,000	0
2019-11-04	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	427,700	$0.00	$0	617,075
2019-11-04	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$192.77	$57,831	0
2019-11-04	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	2,854	$191.96	$547,844	300
2019-11-04	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	12,654	$191.01	$2,417,011	3,154
2019-11-04	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	12,523	$190.00	$2,379,399	15,808
2019-11-04	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	4,569	$189.08	$863,921	28,331
2019-11-04	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	32,900	$29.49	$970,221	32,900
2019-11-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,000	$170.00	$170,000	0
2019-09-04	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	82	$129.40	$10,611	0
2019-09-03	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	230	$144.94	$33,337	0
2019-09-03	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	2,632	$144.41	$380,083	230
2019-08-23	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M · derivative	Share Option (Right to Buy)	102,700	$0.00	$0	357,926
2019-08-23	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	200	$146.36	$29,273	714
2019-08-23	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	6,700	$145.08	$972,008	914
2019-08-23	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	286	$143.01	$40,900	7,614
2019-08-23	Chen Timothy Yung-Cheng	Dir	Exercise / conversion M	American Depositary Shares	7,900	$31.59	$249,561	7,900
2019-08-23	Chen Timothy Yung-Cheng	Dir	Open-market sell S	American Depositary Shares	714	$145.30	$103,745	0
2019-08-12	Glazer Donald W.	Dir	Other disposed transaction J	Ordinary Shares	26,100	$0.00	$0	3,711,426
2019-08-12	Glazer Donald W.	Dir	Other disposed transaction J	American Depositary Shares	13,384	$0.00	$0	0
2019-07-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	66,690	$0.00	$0	1,044,775
2019-07-29	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	65,000	$0.00	$0	882,965
2019-07-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	7,630	$135.10	$1,030,821	0
2019-07-29	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	2,500	$132.83	$332,075	7,630
2019-07-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	5,130	$29.49	$151,284	10,130
2019-07-29	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	5,000	$45.31	$226,550	5,000
2019-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$128.80	$12,880	0
2019-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,087	$127.89	$139,014	100
2019-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	719	$127.19	$91,451	1,187
2019-07-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,200	$125.59	$150,710	1,906
2019-07-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,647	$126.73	$335,441	0
2019-07-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,200	$126.13	$277,496	2,647
2019-06-27	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	3	$126.33	$379	0
2019-06-27	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	427	$124.50	$53,163	3
2019-06-17	Yi Qingqing	Dir	Other disposed transaction J	Ordinary Shares	9,282	$0.00	$0	0
2019-06-05	Yi Qingqing	Dir	Equity grant / award A · derivative	Share Option (Right to Buy)	64,610	$0.00	$0	64,610
2019-05-21	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	28,600	$0.00	$0	947,965
2019-05-21	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	2,200	$130.06	$286,132	0
2019-05-21	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	2,200	$45.31	$99,682	2,200
2019-05-21	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M · derivative	Share Option (Right to Buy)	301,600	$0.00	$0	4,120,000
2019-05-21	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	23,200	$130.21	$3,020,860	0
2019-05-21	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M	American Depositary Shares	23,200	$6.50	$150,800	23,200
2019-05-20	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	3,900	$0.00	$0	976,565
2019-05-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	300	$130.12	$39,036	0
2019-05-20	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	300	$45.31	$13,593	300
2019-05-13	Glazer Donald W.	Dir	Open-market sell S	American Depositary Shares	15,027	$125.11	$1,880,028	0
2019-05-06	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M · derivative	Share Option (Right to Buy)	23,400	$0.00	$0	4,421,600
2019-05-06	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	1,800	$130.01	$234,014	0
2019-05-06	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M	American Depositary Shares	1,800	$6.50	$11,700	1,800
2019-05-01	Wu Xiaobin	President & GM China	Open-market sell S	American Depositary Shares	113	$125.55	$14,187	17,365
2019-05-01	Wu Xiaobin	President & GM China	Open-market sell S	American Depositary Shares	5,657	$124.47	$704,153	17,478
2019-05-01	Wu Xiaobin	President & GM China	Open-market sell S	American Depositary Shares	185	$125.43	$23,205	23,135
2019-04-08	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	183,690	$0.00	$0	1,111,465
2019-04-08	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	147	$145.94	$21,453	0
2019-04-08	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,281	$144.90	$185,617	147
2019-04-08	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	2,304	$143.72	$331,132	1,428
2019-04-08	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	6,159	$142.73	$879,060	3,732
2019-04-08	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	3,439	$141.80	$487,662	9,891
2019-04-08	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	800	$140.49	$112,390	13,330
2019-04-08	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	14,130	$29.49	$416,694	14,130
2019-03-14	Glazer Donald W.	Dir	Open-market sell S	American Depositary Shares	14,973	$136.10	$2,037,825	0
2019-03-13	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	2,392	$0.00	$0	7,674,639
2019-03-13	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	18,577	$0.00	$0	7,677,031
2019-03-11	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	33,345	$0.00	$0	1,295,155
2019-03-11	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	2,565	$130.00	$333,450	0
2019-03-11	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	2,565	$29.49	$75,642	2,565
2019-03-07	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	71	$140.50	$9,976	0
2019-03-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$150.00	$15,000	100
2019-03-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$154.91	$30,983	0
2019-03-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	444	$154.08	$68,411	200
2019-03-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,665	$152.39	$253,735	644
2019-03-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,921	$151.60	$291,233	2,309
2019-03-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,000	$150.55	$301,091	4,230
2019-03-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	600	$154.30	$92,582	0
2019-03-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,958	$152.43	$298,465	600
2019-03-05	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,233	$151.54	$338,387	2,558
2019-03-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	300	$154.38	$46,313	0
2019-03-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,700	$152.57	$259,364	300
2019-03-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,090	$150.77	$918,219	3,700
2019-03-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$154.51	$30,902	0
2019-03-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,686	$152.51	$257,133	400
2019-03-04	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,502	$151.34	$378,661	2,086
2019-03-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	600	$152.14	$91,282	400
2019-03-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,000	$150.00	$150,000	0
2019-03-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	200	$154.07	$30,814	0
2019-03-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	100	$139.46	$13,946	2,600
2019-03-01	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	1,300	$138.53	$180,091	2,700
2018-12-18	Peterson Amy C.	CMO, Immuno-oncology	Exercise / conversion M · derivative	Share Option (Right to Buy)	131,833	$0.00	$0	820,000
2018-12-18	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	611	$135.54	$82,816	0
2018-12-18	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	3,600	$134.81	$485,316	611
2018-12-18	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	2,402	$133.88	$321,585	4,211
2018-12-18	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	1,897	$132.70	$251,735	6,613
2018-12-18	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	1,631	$131.74	$214,860	8,510
2018-12-18	Peterson Amy C.	CMO, Immuno-oncology	Exercise / conversion M	American Depositary Shares	10,141	$29.10	$295,103	10,141
2018-12-17	Peterson Amy C.	CMO, Immuno-oncology	Exercise / conversion M · derivative	Share Option (Right to Buy)	128,167	$0.00	$0	951,833
2018-12-17	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	480	$136.93	$65,726	0
2018-12-17	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	2,296	$136.24	$312,818	480
2018-12-17	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	778	$135.04	$105,065	2,776
2018-12-17	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	1,005	$133.81	$134,479	3,554
2018-12-17	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	1,700	$132.91	$225,953	4,559
2018-12-17	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	2,700	$131.80	$355,852	6,259
2018-12-17	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	900	$130.37	$117,331	8,959
2018-12-17	Peterson Amy C.	CMO, Immuno-oncology	Exercise / conversion M	American Depositary Shares	9,859	$29.10	$286,897	9,859
2018-12-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,307	$136.65	$178,601	400
2018-12-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,171	$135.70	$158,902	1,707
2018-12-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	860	$134.74	$115,877	2,878
2018-12-10	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	400	$137.63	$55,054	0
2018-12-03	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	100	$163.84	$16,384	0
2018-12-03	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	300	$155.53	$46,660	300
2018-12-03	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	400	$154.19	$61,674	600
2018-12-03	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	529	$152.87	$80,867	1,000
2018-12-03	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	800	$151.98	$121,584	1,529
2018-12-03	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,671	$150.98	$403,263	2,329
2018-11-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,190	$148.88	$326,045	4,938
2018-11-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,575	$146.70	$377,749	8,128
2018-11-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,000	$147.82	$147,816	7,128
2018-11-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	800	$149.67	$119,734	4,138
2018-11-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	500	$143.71	$71,855	12,503
2018-11-27	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,148	$145.37	$603,013	13,803
2018-11-27	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,475	$144.62	$502,545	17,951
2018-11-27	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,629	$143.67	$234,040	21,426
2018-11-27	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	800	$146.41	$117,127	13,003
2018-11-27	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$141.12	$28,224	23,855
2018-11-27	Wang Xiaodong	Dir	Equity grant / award G	Ordinary Shares	89,999	$0.00	$0	7,773,608
2018-11-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	805	$141.98	$114,293	24,255
2018-11-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,100	$140.97	$155,070	25,060
2018-11-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,605	$140.05	$364,821	26,160
2018-11-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	968	$138.98	$134,534	28,765
2018-11-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,400	$137.98	$193,174	29,733
2018-11-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,000	$136.77	$273,543	31,133
2018-11-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$134.97	$26,995	33,133
2018-11-19	Glazer Donald W.	Dir	Equity grant / award G	Ordinary Shares	3,138	$0.00	$0	4,127,526
2018-11-12	Peterson Amy C.	CMO, Immuno-oncology	Exercise / conversion M · derivative	Share Option (Right to Buy)	156,871	$0.00	$0	1,080,000
2018-11-12	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	100	$121.56	$12,156	0
2018-11-12	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	109	$117.61	$12,820	100
2018-11-12	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	500	$116.56	$58,281	209
2018-11-12	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	700	$114.96	$80,472	709
2018-11-12	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	1,173	$113.92	$133,630	1,409
2018-11-12	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	2,527	$113.03	$285,632	2,582
2018-11-12	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	4,000	$112.18	$448,720	5,109
2018-11-12	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	2,958	$111.10	$328,638	9,109
2018-11-12	Peterson Amy C.	CMO, Immuno-oncology	Exercise / conversion M	American Depositary Shares	12,067	$29.10	$351,150	12,067
2018-11-09	Peterson Amy C.	CMO, Immuno-oncology	Exercise / conversion M · derivative	Share Option (Right to Buy)	171,886	$0.00	$0	1,236,871
2018-11-09	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	100	$125.97	$12,597	0
2018-11-09	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	322	$123.75	$39,847	100
2018-11-09	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	2,046	$122.55	$250,733	422
2018-11-09	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	2,898	$121.71	$352,704	2,468
2018-11-09	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	2,100	$120.63	$253,325	5,366
2018-11-09	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	1,725	$119.27	$205,740	7,466
2018-11-09	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	4,031	$118.64	$478,218	9,191
2018-11-09	Peterson Amy C.	CMO, Immuno-oncology	Exercise / conversion M	American Depositary Shares	13,222	$29.10	$384,760	13,222
2018-11-08	Peterson Amy C.	CMO, Immuno-oncology	Exercise / conversion M · derivative	Share Option (Right to Buy)	191,243	$0.00	$0	1,408,757
2018-11-08	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	200	$127.61	$25,522	0
2018-11-08	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	7,673	$126.72	$972,320	200
2018-11-08	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	3,949	$126.08	$497,879	7,873
2018-11-08	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	2,423	$124.48	$301,605	11,822
2018-11-08	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	466	$122.86	$57,251	14,245
2018-11-08	Peterson Amy C.	CMO, Immuno-oncology	Exercise / conversion M	American Depositary Shares	14,711	$29.10	$428,090	14,711
2018-09-04	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	2,911	$174.60	$508,247	0
2018-08-30	Glazer Donald W.	Dir	Open-market sell S	American Depositary Shares	1,000	$179.00	$179,000	13,384
2018-08-29	Glazer Donald W.	Dir	Open-market sell S	American Depositary Shares	1,000	$179.00	$179,000	14,384
2018-08-23	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	961	$170.46	$163,815	0
2018-08-23	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	1,400	$169.75	$237,656	961
2018-08-23	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	2,300	$168.94	$388,565	2,361
2018-08-23	Peterson Amy C.	CMO, Immuno-oncology	Open-market sell S	American Depositary Shares	1,108	$167.54	$185,630	4,661
2018-08-13	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	549	$164.11	$90,096	0
2018-08-13	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	700	$159.21	$111,450	549
2018-08-13	Wang Xiaodong	Dir	Open-market sell S	American Depositary Shares	2,200	$157.29	$346,044	1,249
2018-08-02	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Ordinary shares	5,231,900	$108.00	$565,045,200	5,250,491
2018-08-02	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	Ordinary shares	582,200	$108.00	$62,877,600	600,791
2018-07-16	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,550	$164.12	$418,497	0
2018-06-26	OYLER JOHN	Chief Executive Officer	Equity grant / award A · derivative	Share Option (Right to Buy)	1,310,088	$0.00	$0	1,310,088
2018-06-26	OYLER JOHN	Chief Executive Officer	Equity grant / award A	Ordinary Shares	188,266	$0.00	$0	17,453,322
2018-06-06	Yi Qingqing	Dir	Equity grant / award A · derivative	Share Option (Right to Buy)	17,442	$0.00	$0	17,442
2018-06-06	Yi Qingqing	Dir	Equity grant / award A	Ordinary Shares	9,290	$0.00	$0	9,290
2018-04-30	Wu Xiaobin	President & GM China	Equity grant / award A · derivative	Share Option (Right to Buy)	766,599	$0.00	$0	766,599
2018-04-30	Wu Xiaobin	President & GM China	Equity grant / award A	Ordinary Shares	1,149,899	$0.00	$0	1,149,899
2018-04-02	su Jingshyh S	Dir	Equity grant / award A · derivative	Share Option (Right to Buy)	63,290	$0.00	$0	63,290
2018-03-19	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M · derivative	Share Option (Right to Buy)	313,664	$0.00	$0	4,445,000
2018-03-19	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	900	$164.36	$147,923	0
2018-03-19	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	4,636	$163.48	$757,902	900
2018-03-19	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	5,133	$162.79	$835,583	5,536
2018-03-19	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	3,141	$161.62	$507,661	10,669
2018-03-19	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	9,618	$160.60	$1,544,652	13,810
2018-03-19	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	5,200	$159.62	$830,042	23,428
2018-03-19	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	500	$158.45	$79,224	28,628
2018-03-19	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M	American Depositary Shares	24,128	$6.50	$156,832	29,128
2018-03-16	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	141,336	$0.00	$0	4,758,664
2018-03-16	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	Amerian Depositary Shares	400	$157.98	$63,191	5,000
2018-03-16	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	7,264	$157.41	$1,143,430	5,400
2018-03-16	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	2,208	$156.75	$346,095	12,664
2018-03-16	Liang Howard	CFO & Chief Strategy Officer	Open-market sell S	American Depositary Shares	1,000	$154.95	$154,950	14,872
2018-03-16	Liang Howard	CFO & Chief Strategy Officer	Exercise / conversion M	American Depositary Shares	10,872	$6.50	$70,668	15,872
2018-03-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	6,584	$150.57	$991,321	0
2018-03-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	9,032	$149.75	$1,352,531	6,584
2018-03-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,800	$148.61	$416,117	15,616
2018-03-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	700	$147.31	$103,114	18,416
2018-03-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$146.25	$29,249	19,116
2018-03-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	600	$145.31	$87,189	19,316
2018-03-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,546	$143.64	$222,067	19,916
2018-03-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,600	$142.72	$371,084	21,462
2018-03-02	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,300	$141.62	$184,111	24,062
2018-03-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,656	$145.00	$385,116	25,362
2018-03-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	14,354	$144.26	$2,070,747	28,018
2018-03-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	10,303	$143.31	$1,476,472	42,372
2018-03-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,787	$142.20	$680,699	52,675
2018-03-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,350	$141.22	$473,094	57,462
2018-03-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,250	$140.38	$175,470	60,812
2018-03-01	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,600	$139.08	$361,606	62,062
2018-02-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$152.00	$30,400	64,662
2018-02-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$150.98	$15,098	64,862
2018-02-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,117	$149.68	$466,558	64,962
2018-02-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,342	$149.13	$796,675	68,079
2018-02-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	2,302	$147.84	$340,320	73,421
2018-02-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	8,449	$146.96	$1,241,625	75,723
2018-02-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,607	$146.02	$672,722	84,172
2018-02-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,104	$144.86	$739,357	88,779
2018-02-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,117	$143.48	$734,187	93,883
2018-01-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	American Depositary Shares	1,645,148	$101.00	$166,159,948	5,121,404
2018-01-18	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	American Depositary Shares	335,050	$101.00	$33,840,050	708,025
2017-12-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,000	$100.08	$100,080	99,000
2017-12-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	200	$99.05	$19,810	100,000
2017-12-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,700	$97.83	$166,317	100,200
2017-12-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	8,279	$96.68	$800,398	101,900
2017-12-26	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	8,958	$95.55	$855,910	110,179
2017-12-21	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	13,000	$0.00	$0	1,367,500
2017-12-21	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,000	$98.00	$98,000	0
2017-12-21	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,000	$29.51	$29,510	1,000
2017-12-13	Huang Jane	CMO, Hematology	Exercise / conversion M · derivative	Share Option (Right to Buy)	19,500	$0.00	$0	1,380,500
2017-12-13	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	200	$94.53	$18,906	0
2017-12-13	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,300	$94.21	$122,475	200
2017-12-13	Huang Jane	CMO, Hematology	Exercise / conversion M	American Depositary Shares	1,500	$29.51	$44,265	1,500
2017-12-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,800	$96.67	$464,022	119,137
2017-12-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	37,208	$95.62	$3,557,885	123,937
2017-12-08	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	10,809	$94.91	$1,025,851	161,145
2017-12-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$96.66	$9,666	171,954
2017-12-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	5,162	$96.12	$496,175	172,054
2017-12-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	7,743	$94.98	$735,434	177,216
2017-12-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	13,213	$93.94	$1,241,236	184,959
2017-12-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	9,439	$93.23	$880,030	198,172
2017-12-07	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	24,080	$92.06	$2,216,764	207,611
2017-12-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	1,400	$93.96	$131,537	231,691
2017-12-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	4,000	$93.02	$372,090	233,091
2017-12-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	18,046	$92.36	$1,666,794	237,091
2017-12-06	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	8,000	$91.48	$731,803	255,137
2017-12-04	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,100	$86.00	$94,600	0
2017-11-29	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	36,340	$82.92	$3,013,458	263,137
2017-11-28	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	32,985	$85.52	$2,820,864	299,477
2017-11-27	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	235	$87.49	$20,560	332,462
2017-11-27	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	16,346	$86.75	$1,418,022	332,697
2017-11-20	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	1,000	$87.00	$87,000	1,100
2017-11-16	Huang Jane	CMO, Hematology	Open-market sell S	American Depositary Shares	600	$85.00	$51,000	2,100
2017-11-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$80.84	$8,084	349,043
2017-11-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	62,170	$80.29	$4,991,791	349,143
2017-11-15	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	3,798	$79.16	$300,633	411,313
2017-11-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$81.00	$8,100	415,111
2017-11-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	20,407	$80.10	$1,634,501	415,211
2017-11-14	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	39,328	$79.55	$3,128,350	435,618
2017-11-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	100	$84.04	$8,404	474,946
2017-11-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	16,845	$83.24	$1,402,136	475,046
2017-11-13	OYLER JOHN	Chief Executive Officer	Open-market sell S	American Depositary Shares	8,109	$82.67	$670,376	491,891
2017-10-13	BAKER BROS. ADVISORS LP	Dir	Other acquired transaction J	American Depositary Shares	7,102	$0.00	$0	7,102
2017-10-13	BAKER BROS. ADVISORS LP	Dir	Other disposed transaction J	American Depositary Shares	49,200	$0.00	$0	0
2017-09-27	OYLER JOHN	Chief Executive Officer	Equity grant / award A · derivative	Share Option (Right to Buy)	935,000	$0.00	$0	935,000
2017-09-27	OYLER JOHN	Chief Executive Officer	Equity grant / award A	Ordinary Shares	515,000	$0.00	$0	21,745,525
2017-08-22	Peterson Amy C.	CMO, Immuno-oncology	Other disposed transaction F	Ordinary Shares	28,185	$5.39	$151,830	271,815
2017-08-11	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	American Depositary Shares	158,279	$71.00	$11,237,809	3,476,256
2017-08-11	BAKER BROS. ADVISORS LP	Dir	Open-market buy P	American Depositary Shares	17,777	$71.00	$1,262,167	372,975

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count