Financial Metrics

SRPT Sarepta Therapeutics, Inc.

Range: 2016-01-01 to 2026-04-29

Export Quarterly CSV Export Annual CSV

Chart Range:

% Change:

Annual View:

Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-1.31	—	USD/shares	10-Q	2017-05-04
Quarterly	2016-06-30	-1.35	-3.1%	USD/shares	10-Q	2017-08-03
Quarterly	2017-03-31	1.5	+211.1%	USD/shares	10-Q	2018-05-03
Quarterly	2017-06-30	-1.15	-176.7%	USD/shares	10-Q	2018-08-08
Quarterly	2018-03-31	-0.55	+52.2%	USD/shares	10-Q	2018-05-03
Quarterly	2018-06-30	-1.67	-203.6%	USD/shares	10-Q	2018-08-08
Quarterly	2021-06-30	-1.02	+38.9%	USD/shares	10-Q	2022-08-02
Quarterly	2021-09-30	-0.6	+41.2%	USD/shares	10-Q	2022-11-02
Quarterly	2022-03-31	-1.2	-100.0%	USD/shares	10-Q	2023-05-02
Quarterly	2022-06-30	-2.65	-120.8%	USD/shares	10-Q	2023-08-02
Quarterly	2022-09-30	-2.94	-10.9%	USD/shares	10-Q	2023-11-01
Quarterly	2023-03-31	-5.86	-99.3%	USD/shares	10-Q	2024-05-01
Quarterly	2023-06-30	-0.27	+95.4%	USD/shares	10-Q	2024-08-07
Quarterly	2023-09-30	-0.46	-70.4%	USD/shares	10-Q	2024-11-06
Quarterly	2024-03-31	0.37	+180.4%	USD/shares	10-Q	2025-05-06
Quarterly	2024-06-30	0.07	-81.1%	USD/shares	10-Q	2025-08-06
Quarterly	2024-09-30	0.34	+385.7%	USD/shares	10-Q	2025-11-06
Quarterly	2025-03-31	-4.6	-1452.9%	USD/shares	10-Q	2025-05-06
Quarterly	2025-06-30	1.89	+141.1%	USD/shares	10-Q	2025-08-06
Quarterly	2025-09-30	-1.8	-195.2%	USD/shares	10-Q	2025-11-06
Annual	2017-12-31	-0.37	—	USD/shares	10-K	2019-02-28
Annual	2020-12-31	-7.11	-1821.6%	USD/shares	10-K	2023-02-28
Annual	2021-12-31	-5.15	+27.6%	USD/shares	10-K	2024-02-28
Annual	2022-12-31	-8.03	-55.9%	USD/shares	10-K	2025-02-28
Annual	2023-12-31	-5.8	+27.8%	USD/shares	10-K	2026-03-02
Annual	2024-12-31	1.5	+125.9%	USD/shares	10-K	2026-03-02
Annual	2025-12-31	-3.93	-362.0%	USD/shares	10-K	2026-03-02

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2017-09-30	37741000.0	—	USD	10-Q	2017-11-01
Quarterly	2017-12-31	431051000.0	+1042.1%	USD	10-Q	2018-10-31
Quarterly	2018-03-31	430811000.0	-0.1%	USD	10-Q	2018-05-03
Quarterly	2018-06-30	439439000.0	+2.0%	USD	10-Q	2018-08-08
Quarterly	2018-09-30	415446000.0	-5.5%	USD	10-Q	2018-10-31
Quarterly	2021-12-31	563673000.0	+35.7%	USD	10-Q	2022-11-02
Quarterly	2022-09-30	1542770000.0	+173.7%	USD	10-Q	2022-11-02
Quarterly	2022-12-31	1544292000.0	+0.1%	USD	10-Q	2023-11-01
Quarterly	2023-03-31	1234284000.0	-20.1%	USD	10-Q	2023-05-02
Quarterly	2023-06-30	1235517000.0	+0.1%	USD	10-Q	2023-08-02
Quarterly	2023-09-30	1236755000.0	+0.1%	USD	10-Q	2023-11-01
Quarterly	2023-12-31	1237998000.0	+0.1%	USD	10-Q	2024-11-06
Quarterly	2024-03-31	1239246000.0	+0.1%	USD	10-Q	2024-05-01
Quarterly	2024-06-30	1226315000.0	-1.0%	USD	10-Q	2024-08-07
Quarterly	2024-09-30	1227560000.0	+0.1%	USD	10-Q	2024-11-06
Quarterly	2024-12-31	1137124000.0	-7.4%	USD	10-Q	2025-11-06
Quarterly	2025-09-30	1035146000.0	-9.0%	USD	10-Q	2025-11-06
Annual	2016-12-31	17668000.0	—	USD	10-K	2017-02-28
Annual	2017-12-31	431051000.0	+2339.7%	USD	10-K	2019-02-28
Annual	2018-12-31	420554000.0	-2.4%	USD	10-K	2019-02-28
Annual	2021-12-31	563673000.0	+34.0%	USD	10-K	2023-02-28
Annual	2022-12-31	1544292000.0	+174.0%	USD	10-K	2024-02-28
Annual	2023-12-31	1237998000.0	-19.8%	USD	10-K	2025-02-28
Annual	2024-12-31	1137124000.0	-8.1%	USD	10-K	2026-03-02
Annual	2025-12-31	828974000.0	-27.1%	USD	10-K	2026-03-02

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	1168000.0	—	USD	10-Q	2017-05-04
Quarterly	2016-06-30	1587000.0	+35.9%	USD	10-Q	2017-08-03
Quarterly	2016-09-30	2427000.0	+52.9%	USD	10-Q	2017-11-01
Quarterly	2017-03-31	4465000.0	+84.0%	USD	10-Q	2018-05-03
Quarterly	2017-06-30	7336000.0	+64.3%	USD	10-Q	2018-08-08
Quarterly	2017-09-30	8101000.0	+10.4%	USD	10-Q	2018-10-31
Quarterly	2018-03-31	12166000.0	+50.2%	USD	10-Q	2019-05-08
Quarterly	2018-06-30	20863000.0	+71.5%	USD	10-Q	2019-08-07
Quarterly	2018-09-30	40954000.0	+96.3%	USD	10-Q	2019-11-07
Quarterly	2019-03-31	16263000.0	-60.3%	USD	10-Q	2020-05-06
Quarterly	2019-06-30	32945000.0	+102.6%	USD	10-Q	2020-08-05
Quarterly	2019-09-30	42374000.0	+28.6%	USD	10-Q	2020-11-05
Quarterly	2020-03-31	9120000.0	-78.5%	USD	10-Q	2021-05-05
Quarterly	2020-06-30	28289000.0	+210.2%	USD	10-Q	2021-08-04
Quarterly	2020-09-30	53592000.0	+89.4%	USD	10-Q	2021-11-03
Quarterly	2021-03-31	21149000.0	-60.5%	USD	10-Q	2022-05-04
Quarterly	2021-06-30	27043000.0	+27.9%	USD	10-Q	2022-08-02
Quarterly	2021-09-30	36284000.0	+34.2%	USD	10-Q	2022-11-02
Quarterly	2022-03-31	5551000.0	-84.7%	USD	10-Q	2023-05-02
Quarterly	2022-06-30	14629000.0	+163.5%	USD	10-Q	2023-08-02
Quarterly	2022-09-30	22860000.0	+56.3%	USD	10-Q	2023-11-01
Quarterly	2023-03-31	9485000.0	-58.5%	USD	10-Q	2024-05-01
Quarterly	2023-06-30	27394000.0	+188.8%	USD	10-Q	2024-08-07
Quarterly	2023-09-30	57067000.0	+108.3%	USD	10-Q	2024-11-06
Quarterly	2024-03-31	32444000.0	-43.1%	USD	10-Q	2025-05-06
Quarterly	2024-06-30	61611000.0	+89.9%	USD	10-Q	2025-08-06
Quarterly	2024-09-30	98874000.0	+60.5%	USD	10-Q	2025-11-06
Quarterly	2025-03-31	43651000.0	-55.9%	USD	10-Q	2025-05-06
Quarterly	2025-06-30	75447000.0	+72.8%	USD	10-Q	2025-08-06
Quarterly	2025-09-30	98381000.0	+30.4%	USD	10-Q	2025-11-06
Annual	2016-12-31	5341000.0	—	USD	10-K	2019-02-28
Annual	2017-12-31	12000000.0	+124.7%	USD	10-K	2020-02-26
Annual	2018-12-31	61157000.0	+409.6%	USD	10-K	2021-03-01
Annual	2019-12-31	59631000.0	-2.5%	USD	10-K	2022-03-01
Annual	2020-12-31	82202000.0	+37.9%	USD	10-K	2023-02-28
Annual	2021-12-31	38490000.0	-53.2%	USD	10-K	2024-02-28
Annual	2022-12-31	30824000.0	-19.9%	USD	10-K	2025-02-28
Annual	2023-12-31	76106000.0	+146.9%	USD	10-K	2026-03-02
Annual	2024-12-31	136956000.0	+80.0%	USD	10-K	2026-03-02
Annual	2025-12-31	101972000.0	-25.5%	USD	10-K	2026-03-02

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	45697000.0	—	shares	10-Q	2017-05-04
Quarterly	2016-06-30	46157000.0	+1.0%	shares	10-Q	2017-08-03
Quarterly	2016-09-30	48254000.0	+4.5%	shares	10-Q	2017-11-01
Quarterly	2017-03-31	56012000.0	+16.1%	shares	10-Q	2018-05-03
Quarterly	2017-06-30	54976000.0	-1.8%	shares	10-Q	2018-08-08
Quarterly	2017-09-30	61528000.0	+11.9%	shares	10-Q	2018-10-31
Quarterly	2018-03-31	64631000.0	+5.0%	shares	10-Q	2019-05-08
Quarterly	2018-06-30	65484000.0	+1.3%	shares	10-Q	2019-08-07
Quarterly	2018-09-30	66209000.0	+1.1%	shares	10-Q	2019-11-07
Quarterly	2019-03-31	71731000.0	+8.3%	shares	10-Q	2020-05-06
Quarterly	2019-06-30	73958000.0	+3.1%	shares	10-Q	2020-08-05
Quarterly	2019-09-30	74177000.0	+0.3%	shares	10-Q	2020-11-05
Quarterly	2020-03-31	76432000.0	+3.0%	shares	10-Q	2021-05-05
Quarterly	2020-06-30	77968000.0	+2.0%	shares	10-Q	2021-08-04
Quarterly	2020-09-30	78501.0	-99.9%	shares	10-Q	2021-11-03
Quarterly	2021-03-31	79454.0	+1.2%	shares	10-Q	2022-05-04
Quarterly	2021-06-30	79746.0	+0.4%	shares	10-Q	2022-08-02
Quarterly	2021-09-30	79880.0	+0.2%	shares	10-Q	2022-11-02
Quarterly	2022-03-31	87253000.0	+109130.1%	shares	10-Q	2023-05-02
Quarterly	2022-06-30	87511000.0	+0.3%	shares	10-Q	2023-08-02
Quarterly	2022-09-30	87628000.0	+0.1%	shares	10-Q	2023-11-01
Quarterly	2023-03-31	88186000.0	+0.6%	shares	10-Q	2024-05-01
Quarterly	2023-06-30	88743000.0	+0.6%	shares	10-Q	2024-08-07
Quarterly	2023-09-30	88889000.0	+0.2%	shares	10-Q	2024-11-06
Quarterly	2024-03-31	99114000.0	+11.5%	shares	10-Q	2025-05-06
Quarterly	2024-06-30	99144000.0	+0.0%	shares	10-Q	2025-08-06
Quarterly	2024-09-30	100448000.0	+1.3%	shares	10-Q	2025-11-06
Quarterly	2025-03-31	97362000.0	-3.1%	shares	10-Q	2025-05-06
Quarterly	2025-06-30	106623000.0	+9.5%	shares	10-Q	2025-08-06
Quarterly	2025-09-30	100237000.0	-6.0%	shares	10-Q	2025-11-06
Annual	2016-12-31	48697000.0	—	shares	10-K	2019-02-28
Annual	2017-12-31	58818000.0	+20.8%	shares	10-K	2020-02-26
Annual	2018-12-31	66250000.0	+12.6%	shares	10-K	2021-03-01
Annual	2019-12-31	73615000.0	+11.1%	shares	10-K	2022-03-01
Annual	2020-12-31	77956000.0	+5.9%	shares	10-K	2023-02-28
Annual	2021-12-31	81262000.0	+4.2%	shares	10-K	2024-02-28
Annual	2022-12-31	87559000.0	+7.7%	shares	10-K	2025-02-28
Annual	2023-12-31	92398000.0	+5.5%	shares	10-K	2026-03-02
Annual	2024-12-31	107875000.0	+16.8%	shares	10-K	2026-03-02
Annual	2025-12-31	100120000.0	-7.2%	shares	10-K	2026-03-02

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

828,974,000

Total Liabilities (latest annual)

2,209,081,000

Current Liabilities (latest annual)

1,095,290,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-0.4301	—	ratio	10-Q	2017-05-04
Quarterly	2016-06-30	-0.5129	-19.3%	ratio	10-Q	2017-08-03
Quarterly	2016-09-30	-0.1389	+72.9%	ratio	10-Q	2017-11-01
Quarterly	2017-03-31	0.1959	+241.1%	ratio	10-Q	2018-05-03
Quarterly	2017-06-30	0.0557	-71.6%	ratio	10-Q	2018-08-08
Quarterly	2017-09-30	-0.0383	-168.7%	ratio	10-Q	2018-10-31
Quarterly	2018-03-31	-0.0455	-18.9%	ratio	10-Q	2019-11-07
Quarterly	2018-06-30	-0.1563	-243.3%	ratio	10-Q	2019-11-07
Quarterly	2018-09-30	-0.3454	-121.0%	ratio	10-Q	2019-11-07
Quarterly	2019-03-31	-0.0568	+83.5%	ratio	10-Q	2020-11-05
Quarterly	2019-06-30	-0.2515	-342.5%	ratio	10-Q	2020-11-05
Quarterly	2019-09-30	-0.4817	-91.5%	ratio	10-Q	2020-11-05
Quarterly	2020-03-31	-0.0153	+96.8%	ratio	10-Q	2021-11-03
Quarterly	2020-06-30	-0.1446	-846.5%	ratio	10-Q	2021-11-03
Quarterly	2020-09-30	-0.4090	-182.8%	ratio	10-Q	2021-11-03
Quarterly	2021-03-31	-0.3124	+23.6%	ratio	10-Q	2022-11-02
Quarterly	2021-06-30	-0.1678	+46.3%	ratio	10-Q	2022-11-02
Quarterly	2021-09-30	-0.6321	-276.7%	ratio	10-Q	2022-11-02
Quarterly	2022-03-31	-0.1226	+80.6%	ratio	10-Q	2023-11-01
Quarterly	2022-06-30	-0.3186	-160.0%	ratio	10-Q	2023-11-01
Quarterly	2022-09-30	-1.3793	-332.9%	ratio	10-Q	2023-11-01
Quarterly	2023-03-31	-0.7250	+47.4%	ratio	10-Q	2024-11-06
Quarterly	2023-06-30	-0.0323	+95.5%	ratio	10-Q	2024-11-06
Quarterly	2023-09-30	-0.7609	-2256.6%	ratio	10-Q	2024-11-06
Quarterly	2024-03-31	0.0376	+104.9%	ratio	10-Q	2025-11-06
Quarterly	2024-06-30	0.0060	-84.0%	ratio	10-Q	2025-11-06
Quarterly	2024-09-30	0.0624	+940.3%	ratio	10-Q	2025-11-06
Quarterly	2025-03-31	-0.3916	-727.6%	ratio	10-Q	2025-11-06
Quarterly	2025-06-30	0.1451	+137.0%	ratio	10-Q	2025-11-06
Quarterly	2025-09-30	-0.3262	-324.9%	ratio	10-Q	2025-11-06
Annual	2016-12-31	-0.7938	—	ratio	10-K	2019-02-28
Annual	2017-12-31	-0.0642	+91.9%	ratio	10-K	2020-02-26
Annual	2018-12-31	-0.3506	-445.9%	ratio	10-K	2021-03-01
Annual	2019-12-31	-0.8740	-149.3%	ratio	10-K	2022-03-01
Annual	2020-12-31	-0.7274	+16.8%	ratio	10-K	2023-02-28
Annual	2021-12-31	-0.4513	+38.0%	ratio	10-K	2024-02-28
Annual	2022-12-31	-1.8275	-305.0%	ratio	10-K	2025-02-28
Annual	2023-12-31	-0.6237	+65.9%	ratio	10-K	2026-03-02
Annual	2024-12-31	0.1540	+124.7%	ratio	10-K	2026-03-02
Annual	2025-12-31	-0.6255	-506.2%	ratio	10-K	2026-03-02

8-K Material Event Details

38 filings · 90 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

422 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-03-12	Mayo Stephen	—	Open-market sell S	Common Stock	7,239	$17.02	$123,208	1,765
2026-03-11	Estepan Ian Michael	Chief Operating Officer	Other disposed transaction F	Common Stock	1,097	$17.03	$18,682	201,983
2026-03-09	Wong Ryan Ho-Yan	Chief Financial Officer	Other disposed transaction F	Common Stock	113	$16.95	$1,915	135,320
2026-03-09	Wong Ryan Ho-Yan	Chief Financial Officer	Other disposed transaction F	Common Stock	162	$16.95	$2,746	135,433
2026-03-02	Estepan Ian Michael	Chief Operating Officer	Other disposed transaction F	Common Stock	875	$16.20	$14,175	204,699
2026-03-02	Estepan Ian Michael	Chief Operating Officer	Other disposed transaction F	Common Stock	3,301	$16.20	$53,476	205,574
2026-03-02	Rothfuss Cristin	EVP, General Counsel	Other disposed transaction F	Common Stock	408	$16.20	$6,610	139,348
2026-03-01	Estepan Ian Michael	Chief Operating Officer	Exercise / conversion M · derivative	Performance Stock Units	8,125	$0.00	$0	0
2026-03-01	Estepan Ian Michael	Chief Operating Officer	Exercise / conversion M	Common Stock	8,125	—	—	208,875
2026-02-26	Estepan Ian Michael	Chief Operating Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	5,381	$0.00	$0	0
2026-02-26	Estepan Ian Michael	Chief Operating Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	2,069	$0.00	$0	0
2026-02-26	Estepan Ian Michael	Chief Operating Officer	Exercise / conversion M	Common Stock	5,381	$13.71	$73,774	200,750
2026-02-26	Estepan Ian Michael	Chief Operating Officer	Exercise / conversion M	Common Stock	2,069	$13.71	$28,366	195,369
2026-02-25	Estepan Ian Michael	Chief Operating Officer	Equity grant / award A · derivative	Performance Stock Units	1,875	—	—	8,125
2026-01-29	Nicaise Claude	—	Exercise / conversion M · derivative	Stock Option (right to buy)	10,500	$0.00	$0	0
2026-01-29	Nicaise Claude	—	Other disposed transaction F	Common Stock	6,780	$21.23	$143,939	31,532
2026-01-29	Nicaise Claude	—	Exercise / conversion M	Common Stock	10,500	$13.71	$143,955	38,312
2026-01-27	BEHRENS M KATHLEEN	—	Exercise / conversion M · derivative	Stock Option (right to buy)	10,500	$0.00	$0	0
2026-01-27	BEHRENS M KATHLEEN	—	Other disposed transaction F	Common Stock	6,494	$22.17	$143,972	197,482
2026-01-27	BEHRENS M KATHLEEN	—	Exercise / conversion M	Common Stock	10,500	$13.71	$143,955	203,976
2025-12-18	Chambers Michael Andrew	—	Equity grant / award A · derivative	Convertible Senior Notes	—	—	—	—
2025-12-18	Chambers Michael Andrew	—	Other disposed transaction D · derivative	Convertible Senior Notes	—	—	—	—
2025-12-16	Estepan Ian Michael	Chief Operating Officer	Open-market sell S	Common Stock	13,187	$22.31	$294,202	193,300
2025-12-07	INGRAM DOUGLAS S	Chief Executive Officer	Equity grant / award A	Common Stock	269,542	$0.00	$0	929,391
2025-12-07	INGRAM DOUGLAS S	Chief Executive Officer	Equity grant / award A	Common Stock	96,541	$0.00	$0	659,849
2025-12-07	INGRAM DOUGLAS S	Chief Executive Officer	Equity grant / award A	Common Stock	73,001	$0.00	$0	563,308
2025-12-07	INGRAM DOUGLAS S	Chief Executive Officer	Equity grant / award A	Common Stock	50,000	$0.00	$0	490,307
2025-12-01	Wong Ryan Ho-Yan	Chief Financial Officer	Other disposed transaction F	Common Stock	78	$20.96	$1,635	136,045
2025-12-01	Wong Ryan Ho-Yan	Chief Financial Officer	Other disposed transaction F	Common Stock	80	$20.96	$1,677	136,123
2025-11-28	Rothfuss Cristin	EVP, General Counsel	Other disposed transaction F	Common Stock	229	$21.12	$4,836	139,756
2025-11-17	Rodino-Klapac Louise	President, R&D and Tech Ops	Other disposed transaction F	Common Stock	4,582	$18.42	$84,400	224,030
2025-09-03	Rodino-Klapac Louise	President, R&D and Tech Ops	Equity grant / award A	Common Stock	50,000	$0.00	$0	228,612
2025-09-03	Rodino-Klapac Louise	President, R&D and Tech Ops	Equity grant / award A	Common Stock	93,875	$0.00	$0	178,612
2025-08-05	Arif Bilal	Chief Tech Ops Officer	Equity grant / award A · derivative	Performance Stock Units	6,250	$0.00	$0	6,250
2025-07-31	Wong Ryan Ho-Yan	Chief Financial Officer	Other disposed transaction F	Common Stock	327	$16.42	$5,369	17,328
2025-05-16	Barry Richard	—	Exercise / conversion M · derivative	Stock Option (right to buy)	12,350	$0.00	$0	0
2025-05-16	Barry Richard	—	Exercise / conversion M	Common Stock	12,350	$32.63	$402,980	2,966,667
2025-05-13	Barry Richard	—	Exercise / conversion M · derivative	Stock Option (right to buy)	10,500	$0.00	$0	0
2025-05-13	Barry Richard	—	Exercise / conversion M · derivative	Stock Option (right to buy)	9,746	$0.00	$0	0
2025-05-13	Barry Richard	—	Exercise / conversion M	Common Stock	10,500	$13.71	$143,955	2,954,317
2025-05-13	Barry Richard	—	Exercise / conversion M	Common Stock	9,746	$25.18	$245,404	2,943,817
2025-03-12	Nicaise Claude	—	Exercise / conversion M · derivative	Stock Options (right to buy)	9,746	$0.00	$0	0
2025-03-12	Nicaise Claude	—	Open-market sell S	Common Stock	2,491	$99.64	$248,203	27,812
2025-03-12	Nicaise Claude	—	Exercise / conversion M	Common Stock	9,746	$25.18	$245,404	30,303
2025-03-10	Estepan Ian Michael	Chief Financial Officer	Equity grant / award A · derivative	Stock Options (right to buy)	16,644	$0.00	$0	16,644
2025-03-10	Estepan Ian Michael	Chief Financial Officer	Equity grant / award A	Common Stock	8,276	—	—	62,612
2025-03-10	Estepan Ian Michael	Chief Financial Officer	Other disposed transaction F	Common Stock	2,890	$100.13	$289,376	54,336
2025-03-10	Estepan Ian Michael	Chief Financial Officer	Other disposed transaction F	Common Stock	1,051	$100.13	$105,237	57,226
2025-03-10	Connelly Deirdre P	—	Equity grant / award A · derivative	Stock Options (right to buy)	4,792	$0.00	$0	4,792
2025-03-10	Connelly Deirdre P	—	Equity grant / award A	Common Stock	2,383	—	—	5,225
2025-03-07	Estepan Ian Michael	Chief Financial Officer	Other disposed transaction F	Common Stock	9,094	$103.70	$943,048	52,777
2025-03-07	Estepan Ian Michael	Chief Financial Officer	Other disposed transaction F	Common Stock	585	$103.70	$60,664	61,871
2025-03-07	Estepan Ian Michael	Chief Financial Officer	Exercise / conversion M · derivative	Performance Stock Units	5,500	$0.00	$0	0
2025-03-07	Estepan Ian Michael	Chief Financial Officer	Exercise / conversion M	Common Stock	5,500	—	—	58,277
2025-03-06	Estepan Ian Michael	Chief Financial Officer	Exercise / conversion M · derivative	Performance Stock Units	17,500	$0.00	$0	0
2025-03-06	Estepan Ian Michael	Chief Financial Officer	Exercise / conversion M	Common Stock	17,500	—	—	62,456
2025-03-04	Rothfuss Cristin	EVP, General Counsel	Other disposed transaction F	Common Stock	296	$101.34	$29,997	13,325
2025-03-04	Rothfuss Cristin	EVP, General Counsel	Other disposed transaction F	Common Stock	288	$101.34	$29,186	13,037
2025-03-03	Murray Dallan	Chief Customer Officer	Other disposed transaction F	Common Stock	711	$103.77	$73,780	21,506
2025-02-11	Estepan Ian Michael	Chief Financial Officer	Equity grant / award A · derivative	Performance Restricted Stock Units	3,500	$0.00	$0	17,500
2025-01-29	Estepan Ian Michael	Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,533	$0.00	$0	0
2025-01-29	Estepan Ian Michael	Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	14,267	$0.00	$0	0
2025-01-29	Estepan Ian Michael	Chief Financial Officer	Other disposed transaction F	Common Stock	2,613	$117.51	$307,054	46,883
2025-01-29	Estepan Ian Michael	Chief Financial Officer	Exercise / conversion M	Common Stock	1,533	$12.00	$18,396	49,496
2025-01-29	Estepan Ian Michael	Chief Financial Officer	Exercise / conversion M	Common Stock	14,267	$12.00	$171,204	47,963
2024-12-27	Estepan Ian Michael	Chief Financial Officer	Equity grant / award G	Common Stock	250	$0.00	$0	33,696
2024-12-12	Wigzell Hans Lennart Rudolf	—	Exercise / conversion M · derivative	Stock Options (right to buy)	10,500	$0.00	$0	0
2024-12-12	Wigzell Hans Lennart Rudolf	—	Open-market sell S	Common Stock	10,500	$124.84	$1,310,820	22,840
2024-12-12	Wigzell Hans Lennart Rudolf	—	Exercise / conversion M	Common Stock	10,500	$13.71	$143,955	33,340
2024-12-05	Boor Kathryn Jean	—	Open-market sell S	Common Stock	1,636	$125.55	$205,400	5,880
2024-11-26	Rothfuss Cristin	EVP, General Counsel	Equity grant / award A · derivative	Stock Option (right to buy)	4,000	$0.00	$0	4,000
2024-11-26	Rothfuss Cristin	EVP, General Counsel	Equity grant / award A	Common Stock	2,000	$0.00	$0	13,817
2024-11-18	Rodino-Klapac Louise	Head of R&D, CSO	Other disposed transaction F	Common Stock	4,558	$102.89	$468,973	67,630
2024-09-12	Connelly Deirdre P	—	Equity grant / award A · derivative	Stock Option (right to buy)	6,442	$0.00	$0	6,442
2024-09-12	Connelly Deirdre P	—	Equity grant / award A	Common Stock	2,842	$0.00	$0	2,842
2024-09-04	BEHRENS M KATHLEEN	—	Equity grant / award G	Common Stock	746	$0.00	$0	191,093
2024-08-30	Estepan Ian Michael	Chief Financial Officer	Open-market sell S	Common Stock	5,985	$137.36	$822,100	33,946
2024-08-16	Chambers Michael Andrew	—	Open-market buy P	Common Stock	5,648	$134.66	$760,560	284,034
2024-08-16	Chambers Michael Andrew	—	Open-market buy P	Common Stock	18,284	$134.06	$2,451,153	278,386
2024-08-16	Chambers Michael Andrew	—	Open-market buy P	Common Stock	13,106	$133.07	$1,744,015	260,102
2024-07-03	BEHRENS M KATHLEEN	—	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2024-07-03	BEHRENS M KATHLEEN	—	Exercise / conversion M	Common Stock	15,000	$13.90	$208,500	191,839
2024-06-25	Brown Ryan Edward	EVP, General Counsel	Exercise / conversion M · derivative	Stock Option (right to buy)	23,500	$0.00	$0	0
2024-06-25	Brown Ryan Edward	EVP, General Counsel	Open-market sell S	Common Stock	2,549	$164.52	$419,361	17,129
2024-06-25	Brown Ryan Edward	EVP, General Counsel	Open-market sell S	Common Stock	3,840	$163.53	$627,955	19,678
2024-06-25	Brown Ryan Edward	EVP, General Counsel	Open-market sell S	Common Stock	17,581	$162.65	$2,859,550	23,518
2024-06-25	Brown Ryan Edward	EVP, General Counsel	Open-market sell S	Common Stock	4,168	$161.82	$674,466	41,099
2024-06-25	Brown Ryan Edward	EVP, General Counsel	Open-market sell S	Common Stock	975	$160.31	$156,302	45,267
2024-06-25	Brown Ryan Edward	EVP, General Counsel	Open-market sell S	Common Stock	2,200	$159.14	$350,108	46,242
2024-06-25	Brown Ryan Edward	EVP, General Counsel	Open-market sell S	Common Stock	7,644	$158.07	$1,208,287	48,442
2024-06-25	Brown Ryan Edward	EVP, General Counsel	Exercise / conversion M	Common Stock	23,500	$62.77	$1,475,095	56,086
2024-06-24	Brown Ryan Edward	EVP, General Counsel	Other disposed transaction F	Common Stock	2,352	$164.64	$387,233	32,586
2024-06-21	Brown Ryan Edward	EVP, General Counsel	Exercise / conversion M · derivative	Performance Stock Units	6,250	$0.00	$0	0
2024-06-21	Brown Ryan Edward	EVP, General Counsel	Equity grant / award A · derivative	Performance Stock Units	6,250	$0.00	$0	6,250
2024-06-21	Brown Ryan Edward	EVP, General Counsel	Equity grant / award A · derivative	Performance Stock Units	5,500	$0.00	$0	5,500
2024-06-21	Brown Ryan Edward	EVP, General Counsel	Exercise / conversion M	Common Stock	6,250	—	—	34,938
2024-05-02	Murray Dallan	Chief Customer Officer	Open-market sell S	Common Stock	3,635	$140.00	$508,900	18,125
2024-03-11	Boor Kathryn Jean	—	Open-market sell S	Common Stock	761	$122.93	$93,550	7,516
2024-03-08	Arif Bilal	Chief Tech Ops Officer	Other disposed transaction F	Common Stock	472	$123.14	$58,122	25,222
2024-03-08	Wigzell Hans Lennart Rudolf	—	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2024-03-08	Wigzell Hans Lennart Rudolf	—	Open-market sell S	Common Stock	100	$122.39	$12,239	22,840
2024-03-08	Wigzell Hans Lennart Rudolf	—	Open-market sell S	Common Stock	11,745	$123.10	$1,445,810	22,940
2024-03-08	Wigzell Hans Lennart Rudolf	—	Open-market sell S	Common Stock	3,155	$123.85	$390,747	34,685
2024-03-08	Wigzell Hans Lennart Rudolf	—	Exercise / conversion M	Common Stock	15,000	$13.90	$208,500	37,840
2024-03-07	Arif Bilal	Chief Tech Ops Officer	Other disposed transaction F	Common Stock	506	$120.49	$60,968	25,694
2024-03-05	Mayo Stephen	—	Open-market sell S	Common Stock	3,135	$122.96	$385,480	6,621
2024-03-04	Estepan Ian Michael	Chief Financial Officer	Other disposed transaction F	Common Stock	1,389	$125.32	$174,069	37,725
2024-03-01	Nicaise Claude	—	Equity grant / award A · derivative	Stock Option (right to buy)	3,679	$0.00	$0	3,679
2024-03-01	Nicaise Claude	—	Equity grant / award A	Common Stock	1,846	$0.00	$0	18,174
2023-12-01	Arif Bilal	Chief Tech Ops Officer	Other disposed transaction F	Common Stock	3,682	$80.34	$295,812	22,886
2023-11-17	Rodino-Klapac Louise	Head of R&D, CSO	Other disposed transaction F	Common Stock	4,508	$82.98	$374,074	65,751
2023-11-03	Barry Richard	Dir	Open-market buy P	Common Stock	40,000	$78.81	$3,152,400	140,000
2023-11-03	Barry Richard	Dir	Open-market buy P	Common Stock	10,000	$78.81	$788,100	10,000
2023-08-14	Chambers Michael Andrew	Dir	Open-market buy P	Common Stock	4,032	$109.89	$443,076	246,996
2023-08-14	Chambers Michael Andrew	Dir	Open-market buy P	Common Stock	5,947	$109.19	$649,353	242,964
2023-08-11	Chambers Michael Andrew	Dir	Open-market buy P	Common Stock	23,686	$108.05	$2,559,272	237,017
2023-08-10	Chambers Michael Andrew	Dir	Open-market buy P	Common Stock	31,570	$106.26	$3,354,628	213,331
2023-08-10	Chambers Michael Andrew	Dir	Open-market buy P	Common Stock	1,091	$105.90	$115,537	181,761
2023-08-10	Chambers Michael Andrew	Dir	Open-market buy P	Common Stock	2,206	$104.67	$230,902	180,670
2023-08-04	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	15,000	$0.00	$0	0
2023-08-04	Wigzell Hans Lennart Rudolf	Dir	Open-market sell S	Common Stock	15,000	$106.72	$1,600,800	20,994
2023-08-04	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M	Common Stock	15,000	$29.03	$435,450	35,994
2023-06-01	Brown Ryan Edward	EVP, General Counsel	Other disposed transaction F	Common Stock	89	$123.60	$11,000	28,096
2023-03-30	Arif Bilal	Chief Tech Ops Officer	Other disposed transaction F	Common Stock	307	$136.66	$41,955	26,367
2023-03-08	Rodino-Klapac Louise	Head of R&D, CSO	Other disposed transaction F	Common Stock	912	$153.19	$139,709	70,170
2023-03-06	Wigzell Hans Lennart Rudolf	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	3,257	$0.00	$0	3,257
2023-03-06	Wigzell Hans Lennart Rudolf	Dir	Equity grant / award A	Common Stock	1,523	$0.00	$0	20,994
2023-03-01	Arif Bilal	Chief Tech Ops Officer	Other disposed transaction F	Common Stock	172	$147.57	$25,382	22,828
2023-03-01	Arif Bilal	Chief Tech Ops Officer	Other disposed transaction F	Common Stock	80	$147.57	$11,806	22,837
2022-12-31	Arif Bilal	Chief Tech Ops Officer	Equity grant / award A · derivative	Stock Option (right to buy)	30,000	$0.00	$0	30,000
2022-12-19	BEHRENS M KATHLEEN	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	20,000	$0.00	$0	0
2022-12-19	BEHRENS M KATHLEEN	Dir	Exercise / conversion M	Common Stock	20,000	$34.92	$698,400	158,470
2022-11-17	Rodino-Klapac Louise	Head of R&D, CSO	Other disposed transaction F	Common Stock	4,211	$108.52	$456,978	67,998
2022-09-14	Chambers Michael Andrew	Dir	Open-market buy P	Common Stock	6,250	$105.16	$657,250	108,178
2022-09-14	Chambers Michael Andrew	Dir	Open-market buy P	Common Stock	30,106	$104.67	$3,151,195	101,928
2022-09-14	Chambers Michael Andrew	Dir	Open-market buy P	Common Stock	20,744	$103.87	$2,154,679	71,822
2022-09-13	Chambers Michael Andrew	Dir	Equity grant / award A · derivative	Convertible Senior Notes	—	$20,000,000.00	—	—
2022-08-19	Chambers Michael Andrew	Dir	Open-market buy P	Common Stock	6,060	$108.80	$659,328	51,078
2022-08-19	Chambers Michael Andrew	Dir	Open-market buy P	Common Stock	40,110	$108.20	$4,339,902	45,018
2022-06-02	Boor Kathryn Jean	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	8,329	$0.00	$0	8,329
2022-06-02	Boor Kathryn Jean	Dir	Equity grant / award A	Common Stock	4,908	$0.00	$0	4,908
2022-06-01	Brown Ryan Edward	SVP, General Counsel	Other disposed transaction F	Common Stock	54	$72.67	$3,924	25,841
2022-03-07	Estepan Ian Michael	Chief Financial Officer	Equity grant / award A · derivative	Stock Option (right to sell)	48,000	$0.00	$0	48,000
2022-03-07	Estepan Ian Michael	Chief Financial Officer	Equity grant / award A	Common Stock	8,000	$0.00	$0	32,671
2022-03-07	Estepan Ian Michael	Chief Financial Officer	Other disposed transaction F	Common Stock	398	$79.36	$31,585	24,671
2022-03-07	Mayo Stephen	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	5,077	$0.00	$0	5,077
2022-03-07	Mayo Stephen	Dir	Equity grant / award A	Common Stock	2,953	$0.00	$0	7,245
2022-03-04	Estepan Ian Michael	Chief Financial Officer	Other disposed transaction F	Common Stock	1,308	$79.20	$103,594	25,069
2022-03-01	Rodino-Klapac Louise	Head of R&D, CSO	Other disposed transaction F	Common Stock	572	$75.05	$42,929	65,327
2021-12-15	BEHRENS M KATHLEEN	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,000	$0.00	$0	0
2021-12-15	BEHRENS M KATHLEEN	Dir	Exercise / conversion M	Common Stock	5,000	$10.08	$50,400	135,517
2021-12-10	GRAY MARY ANN	Dir	Exercise / conversion M · derivative	Restricted Stock Units	967	$0.00	$0	0
2021-12-10	GRAY MARY ANN	Dir	Exercise / conversion M	Common Stock	967	$0.00	$0	9,403
2021-11-24	Rodino-Klapac Louise	Head of R&D, CSO	Open-market buy P	Common Stock	3,780	$79.33	$299,867	65,678
2021-11-17	INGRAM DOUGLAS S	President & CEO	Open-market buy P	Common Stock	25,026	$79.94	$2,000,578	365,082
2021-11-16	Mayo Stephen	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	8,238	$0.00	$0	8,238
2021-11-16	Mayo Stephen	Dir	Equity grant / award A	Common Stock	4,292	$0.00	$0	4,292
2021-09-08	Estepan Ian Michael	Chief Financial Officer	Other disposed transaction F	Common Stock	1,623	$78.29	$127,065	26,753
2021-06-26	INGRAM DOUGLAS S	President & CEO	Other disposed transaction F	Common Stock	17,812	$80.40	$1,432,085	340,056
2021-06-01	Brown Ryan Edward	SVP, General Counsel	Other disposed transaction F	Common Stock	64	$76.01	$4,865	19,368
2021-03-10	BEHRENS M KATHLEEN	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	5,000	$0.00	$0	0
2021-03-10	BEHRENS M KATHLEEN	Dir	Open-market sell S	Common Stock	5,000	$85.76	$428,800	130,517
2021-03-10	BEHRENS M KATHLEEN	Dir	Exercise / conversion M	Common Stock	5,000	$42.30	$211,500	135,517
2021-03-08	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	10,000	$0.00	$0	0
2021-03-08	Wigzell Hans Lennart Rudolf	Dir	Open-market sell S	Common Stock	10,000	$83.51	$835,100	16,518
2021-03-08	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M	Common Stock	10,000	$34.92	$349,200	26,518
2021-03-03	O'Neill Gilmore Neil	EVP, R&D & CMO	Equity grant / award A	Common Stock	15,000	$0.00	$0	28,546
2021-03-03	Wigzell Hans Lennart Rudolf	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	5,518	$0.00	$0	5,518
2021-03-03	Wigzell Hans Lennart Rudolf	Dir	Equity grant / award A	Common Stock	2,726	$0.00	$0	16,518
2021-02-28	O'Neill Gilmore Neil	EVP, R&D & CMO	Other disposed transaction F	Common Stock	524	$86.97	$45,572	13,546
2020-12-31	INGRAM DOUGLAS S	President & CEO	Other disposed transaction F	Common Stock	37,144	$170.49	$6,332,681	357,868
2020-12-14	Rodino-Klapac Louise	Chief Scientific Officer	Equity grant / award A · derivative	Stock Option (right to buy)	25,000	$0.00	$0	25,000
2020-12-11	Bratica Joseph	Principal Financial Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,115	$0.00	$0	12,285
2020-12-11	Bratica Joseph	Principal Financial Officer	Open-market sell S	Common Stock	1,115	$165.00	$183,975	8,140
2020-12-11	Bratica Joseph	Principal Financial Officer	Exercise / conversion M	Common Stock	1,115	$71.45	$79,667	9,255
2020-12-10	GRAY MARY ANN	Dir	Exercise / conversion M · derivative	Restricted Stock Units	967	$0.00	$0	967
2020-12-10	GRAY MARY ANN	Dir	Exercise / conversion M	Common Stock	967	$0.00	$0	5,710
2020-12-08	Bratica Joseph	Principal Financial Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,125	$0.00	$0	4,500
2020-12-08	Bratica Joseph	Principal Financial Officer	Open-market sell S	Common Stock	1,125	$160.00	$180,000	8,140
2020-12-08	Bratica Joseph	Principal Financial Officer	Exercise / conversion M	Common Stock	1,125	$29.60	$33,300	9,265
2020-08-10	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	10,000	$0.00	$0	10,000
2020-08-10	Wigzell Hans Lennart Rudolf	Dir	Open-market sell S	Common Stock	777	$159.65	$124,048	13,792
2020-08-10	Wigzell Hans Lennart Rudolf	Dir	Open-market sell S	Common Stock	9,223	$158.95	$1,465,996	14,569
2020-08-10	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M	Common Stock	10,000	$34.92	$349,200	23,792
2020-08-07	Barry Richard	Dir	Open-market sell S	Common Stock	3,140	$159.09	$499,543	3,129,140
2020-08-07	Barry Richard	Dir	Open-market sell S	Common Stock	26,860	$158.43	$4,255,430	3,132,280
2020-08-03	Bratica Joseph	Principal Financial Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	1,125	$0.00	$0	5,625
2020-08-03	Bratica Joseph	Principal Financial Officer	Open-market sell S	Common Stock	1,125	$155.00	$174,375	7,832
2020-08-03	Bratica Joseph	Principal Financial Officer	Exercise / conversion M	Common Stock	1,125	$29.60	$33,300	8,957
2020-07-08	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	1,203	$32.63	$39,254	0
2020-07-08	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	218	$13.71	$2,989	0
2020-07-08	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	2,385	$13.71	$32,698	0
2020-07-08	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	1,203	$32.63	$39,254	20,260
2020-07-08	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	218	$13.71	$2,989	19,057
2020-07-08	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	2,385	$13.71	$32,698	18,839
2020-06-22	Howton David T	EVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	45,000	$0.00	$0	7,708
2020-06-22	Howton David T	EVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	56,984	$0.00	$0	0
2020-06-22	Howton David T	EVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	1,858	$0.00	$0	0
2020-06-22	Howton David T	EVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	1,280	$0.00	$0	0
2020-06-22	Howton David T	EVP, General Counsel	Open-market sell S	Common Stock	55,270	$171.50	$9,478,805	31,871
2020-06-22	Howton David T	EVP, General Counsel	Open-market sell S	Common Stock	35,757	$170.59	$6,099,787	87,141
2020-06-22	Howton David T	EVP, General Counsel	Open-market sell S	Common Stock	8,086	$169.56	$1,371,062	122,898
2020-06-22	Howton David T	EVP, General Counsel	Open-market sell S	Common Stock	6,009	$168.61	$1,013,177	130,984
2020-06-22	Howton David T	EVP, General Counsel	Exercise / conversion M	Common Stock	45,000	$29.03	$1,306,350	136,993
2020-06-22	Howton David T	EVP, General Counsel	Exercise / conversion M	Common Stock	56,984	$23.85	$1,359,068	91,993
2020-06-22	Howton David T	EVP, General Counsel	Exercise / conversion M	Common Stock	1,858	$13.71	$25,473	35,009
2020-06-22	Howton David T	EVP, General Counsel	Exercise / conversion M	Common Stock	1,280	$13.71	$17,549	33,151
2020-05-20	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M · derivative	Stock Oprion (right to buy)	5,000	$0.00	$0	0
2020-05-20	Wigzell Hans Lennart Rudolf	Dir	Open-market sell S	Common Stock	854	$151.77	$129,612	13,792
2020-05-20	Wigzell Hans Lennart Rudolf	Dir	Open-market sell S	Common Stock	2,046	$151.22	$309,396	14,646
2020-05-20	Wigzell Hans Lennart Rudolf	Dir	Open-market sell S	Common Stock	2,100	$149.62	$314,202	16,692
2020-05-20	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M	Common Stock	5,000	$10.08	$50,400	18,792
2020-05-15	Barry Richard	Dir	Open-market sell S	Common Stock	4,673	$142.05	$663,800	3,159,140
2020-05-15	Barry Richard	Dir	Open-market sell S	Common Stock	25,327	$141.12	$3,574,146	3,163,813
2020-05-11	Mahatme Sandesh	EVP, CFO & CBO	Equity grant / award G	Common Stock	20,425	$0.00	$0	16,454
2020-03-04	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M · derivative	Stock option (right to buy)	5,000	$0.00	$0	0
2020-03-04	Wigzell Hans Lennart Rudolf	Dir	Open-market sell S	Common Stock	5,000	$116.89	$584,450	13,792
2020-03-04	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M	Common Stock	5,000	$8.46	$42,300	18,792
2020-02-28	GRAY MARY ANN	Dir	Equity grant / award A · derivative	Stock option (right to buy)	3,685	$0.00	$0	3,685
2020-02-28	GRAY MARY ANN	Dir	Equity grant / award A	Common Stock	2,075	$0.00	$0	4,743
2019-12-31	INGRAM DOUGLAS S	President & CEO	Other disposed transaction F	Common Stock	37,185	$129.04	$4,798,352	395,012
2019-12-13	Cumbo Alexander	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock option (right to buy)	26,084	$0.00	$0	20,881
2019-12-13	Cumbo Alexander	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock option (right to buy)	3,895	$0.00	$0	0
2019-12-13	Cumbo Alexander	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock option (right to buy)	2,727	$0.00	$0	1,123
2019-12-13	Cumbo Alexander	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	9,294	$125.50	$1,166,397	1,867
2019-12-13	Cumbo Alexander	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	32,706	$125.50	$4,104,603	11,161
2019-12-13	Cumbo Alexander	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	26,084	$26.24	$684,444	43,867
2019-12-13	Cumbo Alexander	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	3,895	$13.71	$53,400	17,783
2019-12-13	Cumbo Alexander	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	2,727	$13.71	$37,387	13,888
2019-12-10	GRAY MARY ANN	Dir	Exercise / conversion M · derivative	Restricted Stock Units	967	$0.00	$0	1,934
2019-12-10	GRAY MARY ANN	Dir	Exercise / conversion M	Common Stock	967	—	—	2,668
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	7,900	$0.00	$0	5,118
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	5,590	$0.00	$0	0
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	52	$0.00	$0	18
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	2,440	$0.00	$0	2,470
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	8,580	$0.00	$0	18,579
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	4,025	$0.00	$0	1,858
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	5,685	$0.00	$0	1,280
2019-11-22	Howton David T	EVP, General Counsel	Other disposed transaction F	Common Stock	2,804	$107.02	$300,084	25,171
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M	Common Stock	7,900	$23.85	$188,415	27,975
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M	Common Stock	5,590	$13.90	$77,701	20,075
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M	Common Stock	52	$13.71	$713	14,485
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M	Common Stock	2,440	$13.71	$33,452	14,433
2019-11-22	Howton David T	EVP, General Counsel	Open-market sell S	Common Stock	2,957	$105.00	$310,485	11,993
2019-11-22	Howton David T	EVP, General Counsel	Open-market sell S	Common Stock	3,753	$105.00	$394,065	14,950
2019-11-22	Howton David T	EVP, General Counsel	Open-market sell S	Common Stock	18,290	$105.00	$1,920,450	18,703
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M	Common Stock	8,580	$13.90	$119,262	36,993
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M	Common Stock	4,025	$13.71	$55,183	28,413
2019-11-22	Howton David T	EVP, General Counsel	Exercise / conversion M	Common Stock	5,685	$13.71	$77,941	24,388
2019-11-18	Ciambrone William	EVP	Equity grant / award A · derivative	Stock option (right to buy)	80,000	$0.00	$0	80,000
2019-09-13	Barry Richard	Dir	Open-market buy P	Common Stock	3,309	$87.49	$289,504	3,187,065
2019-09-12	Barry Richard	Dir	Open-market buy P	Common Stock	1,691	$87.49	$147,950	3,183,756
2019-09-09	BONNEY MICHAEL W	Dir	Open-market buy P	Common Stock	2,000	$86.74	$173,480	7,051
2019-09-06	BEHRENS M KATHLEEN	Dir	Open-market buy P	Common Stock	2,500	$87.98	$219,950	125,667
2019-09-05	BEHRENS M KATHLEEN	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	5,000	$0.00	$0	0
2019-09-05	BEHRENS M KATHLEEN	Dir	Exercise / conversion M	Common Stock	5,000	$7.80	$39,000	123,167
2019-08-22	Mahatme Sandesh	EVP, CFO & CBO	Equity grant / award G	Common Stock	42,535	$0.00	$0	30,179
2019-08-21	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock Appreciation Right	100,000	$0.00	$0	0
2019-08-21	Mahatme Sandesh	EVP, CFO & CBO	Other disposed transaction F	Common Stock	57,465	$101.50	$5,832,698	72,714
2019-08-21	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	100,000	$23.85	$2,385,000	130,179
2019-08-20	Barry Richard	Dir	Open-market buy P	Common Stock	5,000	$99.32	$496,592	3,182,065
2019-08-15	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	260	$0.00	$0	218
2019-08-15	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	985	$0.00	$0	2,385
2019-08-15	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	2,625	$0.00	$0	0
2019-08-15	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	3,021	$0.00	$0	0
2019-08-15	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	2,863	$0.00	$0	0
2019-08-15	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	260	$13.71	$3,565	30,179
2019-08-15	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	985	$13.71	$13,504	29,919
2019-08-15	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	2,625	$13.90	$36,488	28,934
2019-08-15	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	3,021	$29.03	$87,700	26,309
2019-08-15	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	2,863	$34.92	$99,976	23,288
2019-08-14	Barry Richard	Dir	Open-market buy P	Common Stock	3,700	$122.50	$453,250	3,177,065
2019-08-12	Barry Richard	Dir	Open-market buy P	Common Stock	1,300	$122.50	$159,250	3,173,365
2019-05-24	O'Neill Gilmore Neil	EVP, R&D & CMO	Other disposed transaction F	Common Stock	4,630	$119.31	$552,405	7,370
2019-05-23	O'Neill Gilmore Neil	EVP, R&D & CMO	Exercise / conversion M · derivative	Restricted Stock Units	12,000	$0.00	$0	0
2019-05-23	O'Neill Gilmore Neil	EVP, R&D & CMO	Exercise / conversion M	Common Stock	12,000	—	—	12,000
2019-03-28	Mahatme Sandesh	EVP, CFO & CBO	Other disposed transaction F	Common Stock	2,953	$118.68	$350,462	20,425
2019-03-28	Mahatme Sandesh	EVP, CFO & CBO	Equity grant / award A	Common Stock	6,649	$0.00	$0	23,378
2019-03-19	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	43	$0.00	$0	478
2019-03-19	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	164	$0.00	$0	3,370
2019-03-19	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	3,511	$0.00	$0	2,625
2019-03-19	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock option (right to buy)	11,768	$0.00	$0	0
2019-03-19	Mahatme Sandesh	EVP, CFO & CBO	Other disposed transaction F	Common Stock	2,625	$126.47	$331,984	16,729
2019-03-19	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	43	$13.71	$590	19,354
2019-03-19	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	164	$13.71	$2,248	19,311
2019-03-19	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	3,511	$13.90	$48,803	19,147
2019-03-19	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	11,768	$23.85	$280,667	15,636
2019-03-04	Mahatme Sandesh	EVP, CFO & CBO	Equity grant / award A · derivative	Stock option (right to buy)	55,000	$0.00	$0	55,000
2019-03-04	O'Neill Gilmore Neil	EVP, R&D & CMO	Equity grant / award A · derivative	Stock option (right to buy)	55,000	$0.00	$0	55,000
2019-02-28	Mahatme Sandesh	EVP, CFO & CBO	Other disposed transaction D	Common Stock	4,781	$0.00	$0	3,868
2019-02-07	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock Option (right to buy)	65,000	$0.00	$0	10,466
2019-02-07	Mahatme Sandesh	EVP, CFO & CBO	Open-market sell S	Common Stock	65,000	$145.00	$9,425,000	8,649
2019-02-07	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	65,000	$23.85	$1,550,250	73,649
2019-02-01	Cumbo Alexander	SVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	5,250	$0.00	$0	46,965
2019-02-01	Cumbo Alexander	SVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (right to buy)	2,250	$0.00	$0	0
2019-02-01	Cumbo Alexander	SVP, Chief Commercial Officer	Open-market sell S	Common Stock	15,000	$140.00	$2,100,000	15,266
2019-02-01	Cumbo Alexander	SVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	5,250	$26.24	$137,760	30,266
2019-02-01	Cumbo Alexander	SVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	2,250	$13.90	$31,275	25,016
2019-01-31	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock Option (right to buy)	21,198	$0.00	$0	75,466
2019-01-31	Mahatme Sandesh	EVP, CFO & CBO	Open-market sell S	Common Stock	21,198	$130.72	$2,771,003	8,649
2019-01-31	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	21,198	$23.85	$505,572	29,847
2019-01-30	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock Option (right to buy)	19,345	$0.00	$0	96,664
2019-01-30	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock Option (right to buy)	17,860	$0.00	$0	0
2019-01-30	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock Option (right to buy)	1,128	$0.00	$0	6,771
2019-01-30	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock Option (right to buy)	5,469	$0.00	$0	7,404
2019-01-30	Mahatme Sandesh	EVP, CFO & CBO	Open-market sell S	Common Stock	43,802	$130.00	$5,694,260	8,649
2019-01-30	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	19,345	$23.85	$461,378	52,451
2019-01-30	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	17,860	$13.90	$248,254	33,106
2019-01-30	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	1,128	$13.71	$15,465	15,246
2019-01-30	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	5,469	$13.71	$74,980	14,118
2018-12-10	GRAY MARY ANN	Dir	Equity grant / award A · derivative	Restricted Stock Units	2,901	$0.00	$0	2,901
2018-12-10	GRAY MARY ANN	Dir	Equity grant / award A · derivative	Option (right to buy)	5,711	$0.00	$0	5,711
2018-11-01	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	6,667	$0.00	$0	0
2018-11-01	Wigzell Hans Lennart Rudolf	Dir	Open-market sell S	Common Stock	6,667	$140.50	$936,714	10,084
2018-11-01	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M	Common Stock	6,667	$8.94	$59,603	16,751
2018-10-31	BEHRENS M KATHLEEN	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	10,000	$0.00	$0	0
2018-10-31	BEHRENS M KATHLEEN	Dir	Open-market sell S	Common Stock	10,000	$131.71	$1,317,100	116,534
2018-10-31	BEHRENS M KATHLEEN	Dir	Exercise / conversion M	Common Stock	10,000	$3.96	$39,600	126,534
2018-10-30	INGRAM DOUGLAS S	President & CEO	Open-market buy P	Common Stock	3,134	$120.94	$379,026	415,945
2018-10-30	INGRAM DOUGLAS S	President & CEO	Open-market buy P	Common Stock	13,561	$120.26	$1,630,846	412,811
2018-10-24	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock Option (right to buy)	11,718	$0.00	$0	12,873
2018-10-24	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock Option (right to buy)	29,080	$0.00	$0	7,899
2018-10-24	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock Option (right to buy)	39,006	$0.00	$0	17,860
2018-10-24	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Stock Option (right to buy)	9,596	$0.00	$0	116,009
2018-10-24	Mahatme Sandesh	EVP, CFO & CBO	Equity grant / award G	Common Stock	12,012	$0.00	$0	12,012
2018-10-24	Mahatme Sandesh	EVP, CFO & CBO	Open-market sell S	Common Stock	107,524	$127.74	$13,735,116	20,661
2018-10-24	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	11,718	$13.71	$160,654	128,185
2018-10-24	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	29,080	$13.71	$398,687	116,467
2018-10-24	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	39,006	$13.90	$542,183	87,387
2018-10-24	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	9,596	$23.85	$228,865	48,381
2018-08-15	INGRAM DOUGLAS S	President & CEO	Open-market buy P	Common Stock	16,000	$125.26	$2,004,211	399,250
2018-08-08	Cumbo Alexander	SVP, Chief Commercial Officer	Other disposed transaction F	Common Stock	6,000	$121.02	$726,120	22,766
2018-07-16	Howton David T	SVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	37,848	$13.90	$526,087	27,159
2018-07-16	Howton David T	SVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	9,056	$13.71	$124,158	10,090
2018-07-16	Howton David T	SVP, General Counsel	Exercise / conversion M · derivative	Stock option (right to buy)	3,096	$13.71	$42,446	7,431
2018-07-16	Howton David T	SVP, General Counsel	Open-market sell S	Common Stock	37,848	$136.46	$5,164,738	34,871
2018-07-16	Howton David T	SVP, General Counsel	Exercise / conversion M	Common Stock	37,848	$13.90	$526,087	72,719
2018-07-16	Howton David T	SVP, General Counsel	Open-market sell S	Common Stock	9,056	$136.46	$1,235,782	34,871
2018-07-16	Howton David T	SVP, General Counsel	Exercise / conversion M	Common Stock	9,056	$13.71	$124,158	43,927
2018-07-16	Howton David T	SVP, General Counsel	Open-market sell S	Common Stock	3,096	$136.46	$422,480	34,871
2018-07-16	Howton David T	SVP, General Counsel	Exercise / conversion M	Common Stock	3,096	$13.71	$42,446	37,967
2018-07-09	Cumbo Alexander	SVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock option (right to buy)	11,914	$13.90	$165,605	2,250
2018-07-09	Cumbo Alexander	SVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock option (right to buy)	9,944	$13.71	$136,332	3,895
2018-07-09	Cumbo Alexander	SVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock option (right to buy)	11,924	$13.71	$163,478	3,850
2018-07-09	Cumbo Alexander	SVP, Chief Commercial Officer	Open-market sell S	Common Stock	11,914	$137.32	$1,636,030	28,766
2018-07-09	Cumbo Alexander	SVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	11,914	$13.90	$165,605	40,680
2018-07-09	Cumbo Alexander	SVP, Chief Commercial Officer	Open-market sell S	Common Stock	9,944	$137.32	$1,365,510	28,766
2018-07-09	Cumbo Alexander	SVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	9,944	$13.71	$136,332	38,710
2018-07-09	Cumbo Alexander	SVP, Chief Commercial Officer	Open-market sell S	Common Stock	11,924	$137.32	$1,637,404	28,766
2018-07-09	Cumbo Alexander	SVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	11,924	$13.71	$163,478	40,690
2018-06-27	Barry Richard	Dir	Open-market sell S	Common Stock	75,000	$130.34	$9,775,500	3,170,432
2018-06-26	INGRAM DOUGLAS S	President & CEO	Other disposed transaction F	Common Stock	36,946	$135.53	$5,007,291	383,250
2018-06-07	O'Neill Gilmore Neil	SVP & Chief Medical Officer	Equity grant / award A · derivative	Restricted Stock Units	12,000	$0.00	$0	12,000
2018-06-07	O'Neill Gilmore Neil	SVP & Chief Medical Officer	Equity grant / award A · derivative	Stock option (right to buy)	100,000	$0.00	$0	100,000
2018-05-22	Ruff Shamim	SVP, Chief Regulatory Affairs	Exercise / conversion M · derivative	Restricted Stock Units	4,432	$0.00	$0	0
2018-05-22	Ruff Shamim	SVP, Chief Regulatory Affairs	Other disposed transaction F	Common Stock	1,305	$89.22	$116,432	31,936
2018-05-22	Ruff Shamim	SVP, Chief Regulatory Affairs	Exercise / conversion M	Common Stock	4,432	—	—	33,241
2018-03-15	Ruff Shamim	SVP, Chief Regulatory Affairs	Exercise / conversion M · derivative	Stock option (right to buy)	2,031	$0.00	$0	10,066
2018-03-15	Ruff Shamim	SVP, Chief Regulatory Affairs	Exercise / conversion M · derivative	Stock option (right to buy)	469	$0.00	$0	6,134
2018-03-15	Ruff Shamim	SVP, Chief Regulatory Affairs	Other disposed transaction F	Common Stock	656	$81.22	$53,280	28,809
2018-03-15	Ruff Shamim	SVP, Chief Regulatory Affairs	Exercise / conversion M	Common Stock	2,031	$26.24	$53,293	29,465
2018-03-15	Ruff Shamim	SVP, Chief Regulatory Affairs	Other disposed transaction F	Common Stock	80	$81.22	$6,498	27,434
2018-03-15	Ruff Shamim	SVP, Chief Regulatory Affairs	Exercise / conversion M	Common Stock	469	$13.90	$6,519	27,514
2018-03-05	Wigzell Hans Lennart Rudolf	Dir	Equity grant / award A · derivative	Stock option (right to buy)	4,820	$0.00	$0	4,820
2018-03-05	Wigzell Hans Lennart Rudolf	Dir	Equity grant / award A	Common Stock	3,418	$0.00	$0	10,084
2017-12-04	BONNEY MICHAEL W	Dir	Equity grant / award A · derivative	Non-Qualified Stock Options (right to buy)	16,400	$0.00	$0	16,400
2017-11-30	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	6,667	$7.38	$49,202	0
2017-11-30	Wigzell Hans Lennart Rudolf	Dir	Open-market sell S	Common Stock	6,667	$55.89	$372,619	6,666
2017-11-30	Wigzell Hans Lennart Rudolf	Dir	Exercise / conversion M	Common Stock	6,667	$7.38	$49,202	13,333
2017-11-08	INGRAM DOUGLAS S	President & CEO	Open-market buy P	Common Stock	38,138	$52.44	$1,999,957	420,196
2017-11-06	Ruff Shamim	SVP, Regulatory Affairs & Qual	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	10,000	$14.76	$147,600	31,144
2017-11-06	Ruff Shamim	SVP, Regulatory Affairs & Qual	Open-market sell S	Common Stock	10,000	$55.00	$550,000	27,045
2017-11-06	Ruff Shamim	SVP, Regulatory Affairs & Qual	Exercise / conversion M	Common Stock	10,000	$14.76	$147,600	37,045
2017-10-03	Ruff Shamim	SVP, Regulatory Affairs & Qual	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	11,500	$14.76	$169,740	41,144
2017-10-03	Ruff Shamim	SVP, Regulatory Affairs & Qual	Open-market sell S	Common Stock	11,500	$50.00	$575,000	27,045
2017-10-03	Ruff Shamim	SVP, Regulatory Affairs & Qual	Exercise / conversion M	Common Stock	11,500	$14.76	$169,740	38,545
2017-09-25	Basi Guriqbal S.	SVP, Chief Scientific Officer	Equity grant / award A · derivative	Stock Option (right to buy)	100,000	$0.00	$0	100,000
2017-08-03	Ruff Shamim	SVP, Regulatory Affairs & Qual	Exercise / conversion M · derivative	Restricted Stock Units	8,865	$0.00	$0	0
2017-08-03	Ruff Shamim	SVP, Regulatory Affairs & Qual	Other disposed transaction F	Common Stock	2,882	$37.88	$109,170	27,045
2017-08-03	Ruff Shamim	SVP, Regulatory Affairs & Qual	Exercise / conversion M	Common Stock	8,865	—	—	29,927
2017-07-27	INGRAM DOUGLAS S	President & CEO	Open-market buy P	Common Stock	47,058	$42.50	$1,999,965	382,058
2017-07-21	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,500	$23.85	$35,775	14,268
2017-07-21	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	1,500	$23.85	$35,775	33,861
2017-07-20	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	7,627	$23.85	$181,904	125,605
2017-07-20	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	32,998	$13.90	$458,672	56,866
2017-07-20	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	9,375	$13.71	$128,531	24,591
2017-07-20	Mahatme Sandesh	EVP, CFO & CBO	Open-market sell S	Common Stock	7,627	$41.00	$312,707	32,361
2017-07-20	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	7,627	$23.85	$181,904	39,988
2017-07-20	Mahatme Sandesh	EVP, CFO & CBO	Open-market sell S	Common Stock	32,998	$41.00	$1,352,918	32,361
2017-07-20	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	32,998	$13.90	$458,672	65,359
2017-07-20	Mahatme Sandesh	EVP, CFO & CBO	Open-market sell S	Common Stock	9,375	$41.00	$384,375	32,361
2017-07-20	Mahatme Sandesh	EVP, CFO & CBO	Exercise / conversion M	Common Stock	9,375	$13.71	$128,531	41,736
2017-06-26	INGRAM DOUGLAS S	President & CEO	Equity grant / award A · derivative	Stock Option (right to buy)	3,300,000	$0.00	$0	3,300,000
2017-06-26	INGRAM DOUGLAS S	President & CEO	Equity grant / award A	Common Stock	335,000	$0.00	$0	335,000
2017-05-19	Cumbo Alexander	SVP, Chief Commercial Officer	Equity grant / award A · derivative	Stock Option (right to buy)	40,000	$0.00	$0	40,000
2017-04-20	Kaye Edward M. MD	President & CEO	Other disposed transaction F	Common Stock	4,349	$32.54	$141,516	66,820
2017-04-03	Stehman-Breen Catherine	SVP, Chief Medical Officer	Equity grant / award A · derivative	Stock Option (right to buy)	100,000	$0.00	$0	100,000
2017-03-19	Howton David T	SVP, General Counsel	Other disposed transaction F	Common Stock	152	$30.30	$4,606	22,301
2017-03-10	Cumbo Alexander	VP, Head of Commercial	Equity grant / award A · derivative	Incentive Stock Option (right to buy)	4,924	$0.00	$0	4,924
2017-03-10	Cumbo Alexander	VP, Head of Commercial	Equity grant / award A · derivative	Non-Qualified Stock Option (right to buy)	22,576	$0.00	$0	22,576
2017-01-20	Kaye Edward M. MD	President, CEO & CMO	Other disposed transaction F	Common Stock	4,466	$32.66	$145,860	71,169
2016-11-09	Howton David T	SVP, General Counsel	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,000	$0.00	$0	15,768
2016-11-09	Howton David T	SVP, General Counsel	Exercise / conversion M	Common Stock	1,000	$23.85	$23,850	22,453
2016-11-08	Ruff Shamim	SVP, Regulatory Affairs & Qual	Exercise / conversion M · derivative	Incentive Stock Option (right to buy)	1,000	$0.00	$0	12,097
2016-11-08	Ruff Shamim	SVP, Regulatory Affairs & Qual	Exercise / conversion M	Common Stock	1,000	$26.24	$26,240	21,239
2016-10-20	Kaye Edward M. MD	President, CEO & CMO	Other disposed transaction F	Common Stock	4,348	$49.05	$213,269	72,635
2016-10-17	Mahatme Sandesh	Senior Vice President, CFO	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	30,000	$13.90	$417,000	19,874
2016-10-17	Mahatme Sandesh	Senior Vice President, CFO	Open-market sell S	Common Stock	30,000	$50.08	$1,502,502	31,532
2016-10-17	Mahatme Sandesh	Senior Vice President, CFO	Exercise / conversion M	Common Stock	30,000	$13.90	$417,000	61,532
2016-09-22	Ruff Shamim	SVP, Regulatory Affairs & Qual	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	7,311	$13.90	$101,623	8,486
2016-09-22	Ruff Shamim	SVP, Regulatory Affairs & Qual	Open-market sell S	Common Stock	7,311	$60.00	$438,660	20,239
2016-09-22	Ruff Shamim	SVP, Regulatory Affairs & Qual	Exercise / conversion M	Common Stock	7,311	$13.90	$101,623	27,550
2016-09-19	Aphale Jayant	VP, Technical Operations	Exercise / conversion M · derivative	Incentive Stock Options (right to buy)	25,000	$4.62	$115,500	61,580
2016-09-19	Aphale Jayant	VP, Technical Operations	Exercise / conversion M · derivative	Non-Qualified Stock Options (right to buy)	10,000	$4.62	$46,200	3,420
2016-09-19	Aphale Jayant	VP, Technical Operations	Open-market sell S	Common Stock	25,000	$50.00	$1,250,000	11,490
2016-09-19	Aphale Jayant	VP, Technical Operations	Exercise / conversion M	Common Stock	25,000	$4.62	$115,500	36,490
2016-09-19	Aphale Jayant	VP, Technical Operations	Open-market sell S	Common Stock	10,000	$50.00	$500,000	11,490
2016-09-19	Aphale Jayant	VP, Technical Operations	Exercise / conversion M	Common Stock	10,000	$4.62	$46,200	21,490
2016-09-14	Kaye Edward M. MD	SVP Interim CEO & CMO	Open-market sell S	Common Stock	24,557	$30.00	$736,710	76,983
2016-08-31	Kaye Edward M. MD	SVP Interim CEO & CMO	Other disposed transaction F	Common Stock	1,487	$26.07	$38,766	101,540
2016-07-20	Kaye Edward M. MD	SVP Interim CEO & CMO	Other disposed transaction F	Common Stock	3,001	$22.46	$67,402	103,027
2016-04-20	Kaye Edward M. MD	SVP Interim CEO & CMO	Other disposed transaction F	Common Stock	3,001	$19.71	$59,150	106,028

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count