Financial Metrics

TECH BIO-TECHNE Corp

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	0.81	—	USD/shares	10-Q	2017-05-10
Quarterly	2016-09-30	0.5	-38.3%	USD/shares	10-Q	2017-11-09
Quarterly	2016-12-31	0.2	-60.0%	USD/shares	10-Q	2018-02-08
Quarterly	2017-03-31	0.59	+195.0%	USD/shares	10-Q	2018-05-09
Quarterly	2017-09-30	0.42	-28.8%	USD/shares	10-Q	2018-11-07
Quarterly	2017-12-31	1.29	+207.1%	USD/shares	10-Q	2019-02-07
Quarterly	2018-03-31	0.52	-59.7%	USD/shares	10-Q	2019-05-07
Quarterly	2018-09-30	0.45	-13.5%	USD/shares	10-Q	2019-11-06
Quarterly	2018-12-31	0.45	+0.0%	USD/shares	10-Q	2020-02-06
Quarterly	2019-03-31	1.15	+155.6%	USD/shares	10-Q	2020-05-11
Quarterly	2019-09-30	0.37	-67.8%	USD/shares	10-Q	2020-11-09
Quarterly	2019-12-31	3.02	+716.2%	USD/shares	10-Q	2021-02-08
Quarterly	2020-03-31	0.92	-69.5%	USD/shares	10-Q	2021-05-07
Quarterly	2020-09-30	0.83	-9.8%	USD/shares	10-Q	2021-11-08
Quarterly	2020-12-31	1.15	+38.6%	USD/shares	10-Q	2022-02-07
Quarterly	2021-03-31	1.12	-2.6%	USD/shares	10-Q	2022-05-09
Quarterly	2021-09-30	1.69	+50.9%	USD/shares	10-Q	2022-11-07
Quarterly	2021-12-31	0.49	-71.0%	USD/shares	10-Q	2023-02-07
Quarterly	2022-03-31	0.37	-24.5%	USD/shares	10-Q	2023-05-08
Quarterly	2022-09-30	0.55	+48.6%	USD/shares	10-Q	2023-11-07
Quarterly	2022-12-31	0.31	-43.6%	USD/shares	10-Q	2024-02-07
Quarterly	2023-03-31	0.43	+38.7%	USD/shares	10-Q	2024-05-06
Quarterly	2023-09-30	0.31	-27.9%	USD/shares	10-Q	2024-11-05
Quarterly	2023-12-31	0.17	-45.2%	USD/shares	10-Q	2025-02-06
Quarterly	2024-03-31	0.31	+82.4%	USD/shares	10-Q	2025-05-08
Quarterly	2024-09-30	0.21	-32.3%	USD/shares	10-Q	2025-11-05
Quarterly	2024-12-31	0.22	+4.8%	USD/shares	10-Q	2026-02-04
Quarterly	2025-03-31	0.14	-36.4%	USD/shares	10-Q	2025-05-08
Quarterly	2025-09-30	0.24	+71.4%	USD/shares	10-Q	2025-11-05
Quarterly	2025-12-31	0.24	+0.0%	USD/shares	10-Q	2026-02-04
Annual	2016-12-31	0.2	—	USD/shares	10-K	2018-08-27
Annual	2017-12-31	1.29	+545.0%	USD/shares	10-K/A	2019-11-06
Annual	2018-12-31	0.45	-65.1%	USD/shares	10-K	2020-08-26
Annual	2019-12-31	3.02	+571.1%	USD/shares	10-K	2020-08-26
Annual	2020-06-30	5.82	+92.7%	USD/shares	10-K	2022-08-24
Annual	2021-06-30	0.87	-85.1%	USD/shares	10-K	2023-08-23
Annual	2022-06-30	1.66	+90.8%	USD/shares	10-K	2024-08-22
Annual	2023-06-30	1.76	+6.0%	USD/shares	10-K	2025-08-22
Annual	2024-06-30	1.05	-40.3%	USD/shares	10-K	2025-08-22
Annual	2025-06-30	0.46	-56.2%	USD/shares	10-K	2025-08-22

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	13844000.0	—	USD	10-Q	2017-05-10
Quarterly	2016-09-30	2442000.0	-82.4%	USD	10-Q	2017-11-09
Quarterly	2016-12-31	5295000.0	+116.8%	USD	10-Q	2018-02-08
Quarterly	2017-03-31	9311000.0	+75.8%	USD	10-Q	2018-05-09
Quarterly	2017-09-30	5273000.0	-43.4%	USD	10-Q	2018-11-07
Quarterly	2017-12-31	11608000.0	+120.1%	USD	10-Q	2019-02-07
Quarterly	2018-03-31	15116000.0	+30.2%	USD	10-Q	2019-05-07
Quarterly	2018-09-30	4190000.0	-72.3%	USD	10-Q	2019-11-06
Quarterly	2018-12-31	8794000.0	+109.9%	USD	10-Q	2020-02-06
Quarterly	2019-03-31	13719000.0	+56.0%	USD	10-Q	2020-05-11
Quarterly	2019-09-30	10525000.0	-23.3%	USD	10-Q	2020-11-09
Quarterly	2019-12-31	25089000.0	+138.4%	USD	10-Q	2021-02-08
Quarterly	2020-03-31	34371000.0	+37.0%	USD	10-Q	2021-05-07
Quarterly	2020-09-30	10938000.0	-68.2%	USD	10-Q	2021-11-08
Quarterly	2020-12-31	22383000.0	+104.6%	USD	10-Q	2022-02-07
Quarterly	2021-03-31	32985000.0	+47.4%	USD	10-Q	2022-05-09
Quarterly	2021-09-30	6070000.0	-81.6%	USD	10-Q	2022-11-07
Quarterly	2021-12-31	16238000.0	+167.5%	USD	10-Q	2023-02-07
Quarterly	2022-03-31	31338000.0	+93.0%	USD	10-Q	2023-05-08
Quarterly	2022-09-30	9556000.0	-69.5%	USD	10-Q	2023-11-07
Quarterly	2022-12-31	15665000.0	+63.9%	USD	10-Q	2024-02-07
Quarterly	2023-03-31	27413000.0	+75.0%	USD	10-Q	2024-05-06
Quarterly	2023-09-30	13592000.0	-50.4%	USD	10-Q	2024-11-05
Quarterly	2023-12-31	28456000.0	+109.4%	USD	10-Q	2025-02-06
Quarterly	2024-03-31	44897000.0	+57.8%	USD	10-Q	2025-05-08
Quarterly	2024-09-30	9172000.0	-79.6%	USD	10-Q	2025-11-05
Quarterly	2024-12-31	15993000.0	+74.4%	USD	10-Q	2026-02-04
Quarterly	2025-03-31	26116000.0	+63.3%	USD	10-Q	2025-05-08
Quarterly	2025-09-30	5363000.0	-79.5%	USD	10-Q	2025-11-05
Quarterly	2025-12-31	11284000.0	+110.4%	USD	10-Q	2026-02-04
Annual	2016-06-30	16898000.0	—	USD	10-K	2018-08-27
Annual	2017-06-30	15179000.0	-10.2%	USD	10-K/A	2019-11-06
Annual	2018-06-30	20934000.0	+37.9%	USD	10-K	2020-08-26
Annual	2019-06-30	25411000.0	+21.4%	USD	10-K	2021-08-25
Annual	2020-06-30	51744000.0	+103.6%	USD	10-K	2022-08-24
Annual	2021-06-30	44301000.0	-14.4%	USD	10-K	2023-08-23
Annual	2022-06-30	44908000.0	+1.4%	USD	10-K	2024-08-22
Annual	2023-06-30	38244000.0	-14.8%	USD	10-K	2025-08-22
Annual	2024-06-30	62877000.0	+64.4%	USD	10-K	2025-08-22
Annual	2025-06-30	31006000.0	-50.7%	USD	10-K	2025-08-22

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	37299000.0	—	shares	10-Q	2017-05-10
Quarterly	2016-09-30	37473000.0	+0.5%	shares	10-Q	2017-11-09
Quarterly	2016-12-31	37478000.0	+0.0%	shares	10-Q	2018-02-08
Quarterly	2017-03-31	37494000.0	+0.0%	shares	10-Q	2018-05-09
Quarterly	2017-09-30	37705000.0	+0.6%	shares	10-Q	2018-11-07
Quarterly	2017-12-31	37926000.0	+0.6%	shares	10-Q	2019-02-07
Quarterly	2018-03-31	38142000.0	+0.6%	shares	10-Q	2019-05-07
Quarterly	2018-09-30	38813000.0	+1.8%	shares	10-Q	2019-11-06
Quarterly	2018-12-31	38748000.0	-0.2%	shares	10-Q	2020-02-06
Quarterly	2019-03-31	38861000.0	+0.3%	shares	10-Q	2020-05-11
Quarterly	2019-09-30	39253000.0	+1.0%	shares	10-Q	2020-11-09
Quarterly	2019-12-31	39550000.0	+0.8%	shares	10-Q	2021-02-08
Quarterly	2020-03-31	39435000.0	-0.3%	shares	10-Q	2021-05-07
Quarterly	2020-09-30	40025000.0	+1.5%	shares	10-Q	2021-11-08
Quarterly	2020-12-31	40257000.0	+0.6%	shares	10-Q	2022-02-07
Quarterly	2021-03-31	40676000.0	+1.0%	shares	10-Q	2022-05-09
Quarterly	2021-09-30	41158000.0	+1.2%	shares	10-Q	2022-11-07
Quarterly	2021-12-31	164828000.0	+300.5%	shares	10-Q	2023-02-07
Quarterly	2022-03-31	163874000.0	-0.6%	shares	10-Q	2023-05-08
Quarterly	2022-09-30	162172000.0	-1.0%	shares	10-Q	2023-11-07
Quarterly	2022-12-31	161750000.0	-0.3%	shares	10-Q	2024-02-07
Quarterly	2023-03-31	161615000.0	-0.1%	shares	10-Q	2024-05-06
Quarterly	2023-09-30	161940000.0	+0.2%	shares	10-Q	2024-11-05
Quarterly	2023-12-31	160060000.0	-1.2%	shares	10-Q	2025-02-06
Quarterly	2024-03-31	160496000.0	+0.3%	shares	10-Q	2025-05-08
Quarterly	2024-09-30	161115000.0	+0.4%	shares	10-Q	2025-11-05
Quarterly	2024-12-31	160626000.0	-0.3%	shares	10-Q	2026-02-04
Quarterly	2025-03-31	158944000.0	-1.0%	shares	10-Q	2025-05-08
Quarterly	2025-09-30	156362000.0	-1.6%	shares	10-Q	2025-11-05
Quarterly	2025-12-31	156999000.0	+0.4%	shares	10-Q	2026-02-04
Annual	2016-12-31	37478000.0	—	shares	10-K	2018-08-27
Annual	2017-12-31	37926000.0	+1.2%	shares	10-K/A	2019-11-06
Annual	2018-12-31	38748000.0	+2.2%	shares	10-K	2020-08-26
Annual	2019-12-31	39550000.0	+2.1%	shares	10-K	2020-08-26
Annual	2020-06-30	39401000.0	-0.4%	shares	10-K	2022-08-24
Annual	2021-06-30	161932000.0	+311.0%	shares	10-K	2023-08-23
Annual	2022-06-30	164114000.0	+1.3%	shares	10-K	2024-08-22
Annual	2023-06-30	161855000.0	-1.4%	shares	10-K	2025-08-22
Annual	2024-06-30	160774000.0	-0.7%	shares	10-K	2025-08-22
Annual	2025-06-30	159717000.0	-0.7%	shares	10-K	2025-08-22

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

N/A

Total Liabilities (latest annual)

N/A

Current Liabilities (latest annual)

175,849,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	0.0355	—	ratio	10-Q	2017-05-10
Quarterly	2016-09-30	0.0210	-40.7%	ratio	10-Q	2017-11-09
Quarterly	2016-12-31	0.0084	-60.2%	ratio	10-Q	2018-02-08
Quarterly	2017-03-31	0.0244	+191.2%	ratio	10-Q	2018-05-09
Quarterly	2017-09-30	0.0165	-32.3%	ratio	10-Q	2019-05-07
Quarterly	2017-12-31	0.0490	+196.3%	ratio	10-Q	2019-05-07
Quarterly	2018-03-31	0.0187	-61.9%	ratio	10-Q	2019-05-07
Quarterly	2018-09-30	0.0157	-15.9%	ratio	10-Q	2020-05-11
Quarterly	2018-12-31	0.0160	+2.1%	ratio	10-Q	2020-05-11
Quarterly	2019-03-31	0.0390	+143.3%	ratio	10-Q	2020-05-11
Quarterly	2019-09-30	0.0123	-68.5%	ratio	10-Q	2021-05-07
Quarterly	2019-12-31	0.0904	+637.2%	ratio	10-Q	2021-05-07
Quarterly	2020-03-31	0.0282	-68.8%	ratio	10-Q	2021-05-07
Quarterly	2020-09-30	0.0232	-17.8%	ratio	10-Q	2022-05-09
Quarterly	2020-12-31	0.0301	+29.9%	ratio	10-Q	2022-05-09
Quarterly	2021-03-31	0.0293	-2.7%	ratio	10-Q	2022-05-09
Quarterly	2021-09-30	0.0419	+42.8%	ratio	10-Q	2023-05-08
Quarterly	2021-12-31	0.0423	+1.1%	ratio	10-Q	2023-05-08
Quarterly	2022-03-31	0.0351	-17.1%	ratio	10-Q	2023-05-08
Quarterly	2022-09-30	0.0512	+46.0%	ratio	10-Q	2024-05-06
Quarterly	2022-12-31	0.0274	-46.6%	ratio	10-Q	2024-05-06
Quarterly	2023-03-31	0.0372	+35.8%	ratio	10-Q	2024-05-06
Quarterly	2023-09-30	0.0255	-31.3%	ratio	10-Q	2025-05-08
Quarterly	2023-12-31	0.0140	-45.2%	ratio	10-Q	2025-05-08
Quarterly	2024-03-31	0.0244	+74.1%	ratio	10-Q	2025-05-08
Quarterly	2024-09-30	0.0157	-35.5%	ratio	10-Q	2026-02-04
Quarterly	2024-12-31	0.0168	+6.8%	ratio	10-Q	2026-02-04
Quarterly	2025-03-31	0.0112	-33.3%	ratio	10-Q	2025-05-08
Quarterly	2025-09-30	0.0194	+73.5%	ratio	10-Q	2026-02-04
Quarterly	2025-12-31	0.0189	-2.7%	ratio	10-Q	2026-02-04
Annual	2020-06-30	0.1660	—	ratio	10-K	2022-08-24
Annual	2021-06-30	0.0888	-46.5%	ratio	10-K	2023-08-23
Annual	2022-06-30	0.1547	+74.1%	ratio	10-K	2024-08-22
Annual	2023-06-30	0.1452	-6.2%	ratio	10-K	2025-08-22
Annual	2024-06-30	0.0813	-44.0%	ratio	10-K	2025-08-22
Annual	2025-06-30	0.0383	-52.9%	ratio	10-K	2025-08-22

8-K Material Event Details

35 filings · 100 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

599 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-04-03	Bohnen Shane	SVP - General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	2,259	$0.00	$0	0
2026-04-03	Bohnen Shane	SVP - General Counsel	Other disposed transaction F	Common Stock	740	$53.13	$39,316	5,904
2026-04-03	Bohnen Shane	SVP - General Counsel	Exercise / conversion M	Common Stock	2,259	$0.00	$0	6,644
2026-03-02	Crouse Steven C.	President - Diag & Spatial Bi	Equity grant / award A · derivative	Stock Option (right to buy)	1,911	$0.00	$0	1,911
2026-03-02	Crouse Steven C.	President - Diag & Spatial Bi	Equity grant / award A · derivative	Restricted Stock Units	735	$0.00	$0	735
2026-03-02	Crouse Steven C.	President - Diag & Spatial Bi	Equity grant / award A · derivative	Performance Restricted Stock Units	2,387	$0.00	$0	2,387
2026-02-17	Herr Amy E.	Dir	Open-market sell S	Common Stock	1,976	$59.10	$116,791	200
2026-02-03	Herr Amy E.	Dir	Exercise / conversion M · derivative	Restricted Stock Units	38	$0.00	$0	77
2026-02-03	Herr Amy E.	Dir	Other disposed transaction F	Common Stock	16	$64.63	$1,034	2,176
2026-02-03	Herr Amy E.	Dir	Exercise / conversion M	Common Stock	38	$0.00	$0	2,192
2026-02-01	McManus Matthew	President - Diag & Spatial Bio	Exercise / conversion M · derivative	Restricted Stock Units	4,621	$0.00	$0	4,620
2026-02-01	McManus Matthew	President - Diag & Spatial Bio	Other disposed transaction F	Common Stock	1,665	$64.09	$106,710	7,691
2026-02-01	McManus Matthew	President - Diag & Spatial Bio	Exercise / conversion M	Common Stock	4,621	$0.00	$0	9,356
2025-11-03	Kelderman Kim	Chief Executive Officer	Other disposed transaction F	Common Stock	2,303	$62.57	$144,099	48,665
2025-10-30	Bushman Julie L	Dir	Equity grant / award A · derivative	Stock Options (Right to Buy)	3,777	$0.00	$0	3,777
2025-10-30	Bushman Julie L	Dir	Equity grant / award A	Common Stock	1,640	$0.00	$0	8,775
2025-08-25	Nusse Roeland	Dir	Exercise / conversion M · derivative	Stock Options (Right to Buy)	17,040	$0.00	$0	0
2025-08-25	Nusse Roeland	Dir	Open-market sell S	Common Stock	17,040	$56.36	$960,388	44,559
2025-08-25	Nusse Roeland	Dir	Exercise / conversion M	Common Stock	17,040	$21.84	$372,154	61,599
2025-08-15	Hippel James	CFO	Equity grant / award A · derivative	Stock Options (Right to Buy)	37,632	$0.00	$0	37,632
2025-08-15	Hippel James	CFO	Equity grant / award A · derivative	Restricted Stock Units	14,710	$0.00	$0	14,710
2025-08-15	Hippel James	CFO	Equity grant / award A · derivative	Performance Restricted Stock Units	29,420	$0.00	$0	29,420
2025-08-15	Hippel James	CFO	Exercise / conversion M · derivative	Restricted Stock Units	4,010	$0.00	$0	8,021
2025-08-15	Hippel James	CFO	Other disposed transaction F	Common Stock	1,926	$53.60	$103,234	129,883
2025-08-15	Hippel James	CFO	Exercise / conversion M	Common Stock	4,010	$0.00	$0	131,809
2025-08-07	HIGGINS JOHN L	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,040	$0.00	$0	0
2025-08-07	HIGGINS JOHN L	Dir	Exercise / conversion M	Common Stock	5,040	$21.84	$110,074	65,236
2025-07-29	Hippel James	CFO	Exercise / conversion M · derivative	Stock Options (Right to Buy)	168,620	$0.00	$0	0
2025-07-29	Hippel James	CFO	Other disposed transaction F	Common Stock	147,431	$58.55	$8,632,085	127,799
2025-07-29	Hippel James	CFO	Exercise / conversion M	Common Stock	168,620	$44.33	$7,474,925	275,230
2025-07-22	Kelderman Kim	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	48,176	$0.00	$0	0
2025-07-22	Kelderman Kim	Chief Executive Officer	Other disposed transaction F	Common Stock	43,649	$53.12	$2,318,635	46,730
2025-07-22	Kelderman Kim	Chief Executive Officer	Exercise / conversion M	Common Stock	48,176	$44.33	$2,135,642	90,379
2025-07-15	Kelderman Kim	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	36,132	$0.00	$0	48,176
2025-07-15	Kelderman Kim	Chief Executive Officer	Other disposed transaction F	Common Stock	32,933	$51.42	$1,693,415	42,203
2025-07-15	Kelderman Kim	Chief Executive Officer	Exercise / conversion M	Common Stock	36,132	$44.33	$1,601,732	75,136
2025-06-09	Herr Amy E.	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,280	$0.00	$0	0
2025-06-09	Herr Amy E.	Dir	Open-market sell S	Common Stock	1,280	$49.77	$63,705	1,976
2025-06-09	Herr Amy E.	Dir	Exercise / conversion M	Common Stock	1,280	$44.33	$56,742	3,256
2025-05-01	HIGGINS JOHN L	Dir	Exercise / conversion M · derivative	Stock Options (Right to Buy)	12,000	$0.00	$0	5,040
2025-05-01	HIGGINS JOHN L	Dir	Exercise / conversion M	Common Stock	12,000	$21.84	$262,080	60,196
2025-04-03	Bohnen Shane	SVP - General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	2,260	$0.00	$0	2,259
2025-04-03	Bohnen Shane	SVP - General Counsel	Other disposed transaction F	Common Stock	747	$54.86	$40,980	3,194
2025-04-03	Bohnen Shane	SVP - General Counsel	Exercise / conversion M	Common Stock	2,260	$0.00	$0	3,941
2025-02-14	Herr Amy E.	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,976	$0.00	$0	1,280
2025-02-14	Herr Amy E.	Dir	Open-market sell S	Common Stock	1,860	$65.96	$122,691	1,976
2025-02-14	Herr Amy E.	Dir	Exercise / conversion M	Common Stock	1,976	$44.33	$87,596	3,836
2025-02-03	Herr Amy E.	Dir	Equity grant / award A · derivative	Restricted Stock Units	115	$0.00	$0	115
2025-02-03	Herr Amy E.	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	344	$0.00	$0	344
2025-02-03	Herr Amy E.	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	2,415	$0.00	$0	2,415
2025-02-03	Herr Amy E.	Dir	Equity grant / award A	Common Stock	1,040	$0.00	$0	1,040
2025-02-01	McManus Matthew	President - DGS	Exercise / conversion M · derivative	Restricted Stock Units	4,620	$0.00	$0	9,241
2025-02-01	McManus Matthew	President - DGS	Other disposed transaction F	Common Stock	1,642	$73.55	$120,769	2,978
2025-02-01	McManus Matthew	President - DGS	Exercise / conversion M	Common Stock	4,620	$0.00	$0	4,620
2025-01-27	Kelderman Kim	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	13,392	$0.00	$0	0
2025-01-27	Kelderman Kim	Chief Executive Officer	Open-market sell S	Common Stock	1,661	$77.95	$129,480	39,004
2025-01-27	Kelderman Kim	Chief Executive Officer	Open-market sell S	Common Stock	11,731	$77.19	$905,533	40,665
2025-01-27	Kelderman Kim	Chief Executive Officer	Exercise / conversion M	Common Stock	13,392	$37.70	$504,878	52,396
2024-11-01	Geist William	PRESIDENT, PROTEIN SCIENCES	Exercise / conversion M · derivative	Restricted Stock Units	9,912	$0.00	$0	9,911
2024-11-01	Geist William	PRESIDENT, PROTEIN SCIENCES	Other disposed transaction F	Common Stock	3,270	$75.31	$246,264	11,081
2024-11-01	Geist William	PRESIDENT, PROTEIN SCIENCES	Exercise / conversion M	Common Stock	9,912	$0.00	$0	14,351
2024-10-24	KEEGAN JOSEPH D	Dir	Equity grant / award A · derivative	Stock Options (Right to Buy)	3,511	$0.00	$0	3,511
2024-10-24	KEEGAN JOSEPH D	Dir	Equity grant / award A	Common Stock	1,462	$0.00	$0	13,771
2024-09-12	HIGGINS JOHN L	Dir	Exercise / conversion M · derivative	Stock Options (Right to Buy)	6,000	$0.00	$0	0
2024-09-12	HIGGINS JOHN L	Dir	Other disposed transaction F	Common Stock	1,874	$73.20	$137,177	46,734
2024-09-12	HIGGINS JOHN L	Dir	Exercise / conversion M	Common Stock	6,000	$22.95	$137,700	48,608
2024-08-29	Kelderman Kim	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,492	$0.00	$0	115,724
2024-08-29	Kelderman Kim	Chief Executive Officer	Exercise / conversion M	Common Stock	1,492	$66.97	$99,919	41,434
2024-08-15	Hippel James	CFO	Equity grant / award A · derivative	Stock Options (Right to Buy)	32,417	$0.00	$0	32,417
2024-08-15	Hippel James	CFO	Equity grant / award A · derivative	Restricted Stock Units	12,031	$0.00	$0	12,031
2024-08-15	Hippel James	CFO	Equity grant / award A · derivative	Performance Restricted Stock Units	24,062	$0.00	$0	24,062
2024-08-15	McManus Matthew	President - DGS	Equity grant / award A · derivative	Performance Restricted Stock Units	15,825	$0.00	$0	15,825
2024-08-08	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M · derivative	Stock Options (Right to Buy)	16,000	$0.00	$0	0
2024-08-08	BAUMGARTNER ROBERT V	Dir	Open-market sell S	Common Stock	16,000	$72.10	$1,153,664	43,401
2024-08-08	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M	Common Stock	16,000	$22.95	$367,200	59,401
2024-08-02	Hippel James	CFO	Exercise / conversion M · derivative	Stock Options (Right to Buy)	53,000	$0.00	$0	53,867
2024-08-02	Hippel James	CFO	Other disposed transaction F	Common Stock	36,076	$82.35	$2,970,859	99,926
2024-08-02	Hippel James	CFO	Exercise / conversion M	Common Stock	53,000	$31.26	$1,656,780	136,002
2024-07-31	Kelderman Kim	Chief Executive Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	14,000	$0.00	$0	13,392
2024-07-31	Kelderman Kim	Chief Executive Officer	Other disposed transaction F	Common Stock	9,479	$81.97	$776,994	39,942
2024-07-31	Kelderman Kim	Chief Executive Officer	Exercise / conversion M	Common Stock	14,000	$37.70	$527,800	49,421
2024-07-23	Hippel James	CFO	Exercise / conversion M · derivative	Stock Options (Right to Buy)	35,000	$0.00	$0	106,867
2024-07-23	Hippel James	CFO	Other disposed transaction F	Common Stock	24,282	$77.77	$1,888,411	83,002
2024-07-23	Hippel James	CFO	Exercise / conversion M	Common Stock	35,000	$31.26	$1,094,100	107,284
2024-07-08	HIGGINS JOHN L	Dir	Exercise / conversion M · derivative	Stock Options (Right to Buy)	6,000	$0.00	$0	6,000
2024-07-08	HIGGINS JOHN L	Dir	Exercise / conversion M	Common Stock	6,000	$22.95	$137,700	42,608
2024-05-14	HIGGINS JOHN L	Dir	Exercise / conversion M · derivative	Stock Options (Right to Buy)	4,000	$0.00	$0	12,000
2024-05-14	HIGGINS JOHN L	Dir	Open-market sell S	Common Stock	4,000	$83.84	$335,377	36,608
2024-05-14	HIGGINS JOHN L	Dir	Exercise / conversion M	Common Stock	4,000	$22.95	$91,800	40,608
2024-05-01	Klimovsky Judith V	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	1,610	$0.00	$0	1,610
2024-05-01	Klimovsky Judith V	Dir	Equity grant / award A	Common Stock	680	$0.00	$0	680
2024-04-03	Bohnen Shane	SVP - General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	2,259	$0.00	$0	4,519
2024-04-03	Bohnen Shane	SVP - General Counsel	Other disposed transaction F	Common Stock	747	$67.87	$50,699	1,647
2024-04-03	Bohnen Shane	SVP - General Counsel	Exercise / conversion M	Common Stock	2,259	—	—	2,394
2024-03-07	Nusse Roeland	Dir	Open-market sell S	Common Stock	10,400	$76.98	$800,627	43,097
2024-02-01	Kelderman Kim	Chief Operating Officer	Equity grant / award A · derivative	Stock Options (Right to Buy)	51,890	$0.00	$0	51,890
2024-02-01	Kelderman Kim	Chief Operating Officer	Equity grant / award A · derivative	Stock Options (Right to Buy)	25,945	$0.00	$0	25,945
2024-02-01	Kelderman Kim	Chief Operating Officer	Equity grant / award A · derivative	Restricted Stock Units	9,423	$0.00	$0	9,423
2024-02-01	Geist William	PRESIDENT, PROTEIN SCIENCES	Other disposed transaction F	Common Stock	1,111	$68.54	$76,148	7,759
2023-12-19	Hippel James	CFO	Exercise / conversion M · derivative	Stock Options (Right to Buy)	47,289	$0.00	$0	141,867
2023-12-19	Hippel James	CFO	Other disposed transaction F	Common Stock	32,966	$77.42	$2,552,228	71,884
2023-12-19	Hippel James	CFO	Exercise / conversion M	Common Stock	47,289	$31.26	$1,478,254	104,850
2023-11-01	Geist William	PRESIDENT, PROTEIN SCIENCES	Equity grant / award A · derivative	Restricted Stock Units	19,823	$0.00	$0	19,823
2023-10-26	Seth Alpna	Dir	Equity grant / award A · derivative	Stock Options (Right to Buy)	3,937	$0.00	$0	3,937
2023-10-26	Seth Alpna	Dir	Equity grant / award A	Common Stock	1,625	$0.00	$0	12,309
2023-08-30	Nusse Roeland	Dir	Exercise / conversion M · derivative	Stock Options (Right to Buy)	16,000	$0.00	$0	0
2023-08-30	Nusse Roeland	Dir	Open-market sell S	Common Stock	8,939	$80.32	$717,959	51,872
2023-08-30	Nusse Roeland	Dir	Exercise / conversion M	Common Stock	16,000	$22.95	$367,200	60,811
2023-08-24	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,100	$0.00	$0	109,536
2023-08-24	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M	Common Stock	2,100	$47.60	$99,960	21,225
2023-08-15	Hippel James	CFO	Equity grant / award A · derivative	Stock Options (Right to Buy)	45,923	$0.00	$0	45,923
2023-08-15	Hippel James	CFO	Equity grant / award A · derivative	Stock Options (Right to Buy)	34,442	$0.00	$0	34,442
2023-08-15	Hippel James	CFO	Equity grant / award A · derivative	Restricted Stock Units	12,798	$0.00	$0	12,798
2023-08-15	Geist William	PRESIDENT, PROTEIN SCIENCES	Equity grant / award A · derivative	Stock Options (Right to Buy)	24,424	$0.00	$0	24,424
2023-08-15	Geist William	PRESIDENT, PROTEIN SCIENCES	Equity grant / award A · derivative	Restricted Stock Units	9,074	$0.00	$0	9,074
2023-08-09	Kummeth Charles R.	Chief Executive Officer	Equity grant / award G	Common Stock	9,008	$0.00	$0	1,269,312
2023-08-05	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Restricted Stock Units	51,516	$0.00	$0	0
2023-08-05	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction F	Common Stock	31,962	$82.17	$2,626,318	1,278,320
2023-08-05	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	51,516	$0.00	$0	1,310,282
2023-07-21	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	80,000	$88.36	$7,069,024	1,258,766
2023-06-30	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	616,676	$0.00	$0	0
2023-06-30	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction F	Common Stock	390,727	$81.63	$31,895,045	1,338,766
2023-06-30	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	616,676	$26.65	$16,434,415	1,729,493
2023-06-07	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	322	$83.00	$26,726	1,112,817
2023-04-28	HIGGINS JOHN L	Dir	Exercise / conversion M · derivative	Stock Options (Right to Buy)	16,000	$0.00	$0	0
2023-04-28	HIGGINS JOHN L	Dir	Other disposed transaction F	Common Stock	4,377	$79.88	$349,635	34,983
2023-04-28	HIGGINS JOHN L	Dir	Exercise / conversion M	Common Stock	16,000	$21.85	$349,600	39,360
2023-04-19	Nusse Roeland	Dir	Equity grant / award G	Common Stock	377	$0.00	$0	28,811
2023-04-03	Bohnen Shane	SVP - General Counsel	Equity grant / award A · derivative	Stock Option (right to buy)	3,928	$0.00	$0	3,928
2023-04-03	Bohnen Shane	SVP - General Counsel	Equity grant / award A · derivative	Restricted Stock Units	6,778	$0.00	$0	6,778
2023-01-04	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	407,364	$0.00	$0	616,676
2023-01-04	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction F	Common Stock	255,837	$84.39	$21,590,084	1,113,139
2023-01-04	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	407,364	$26.65	$10,856,251	1,368,976
2022-12-08	Furlow Brenda S.	SVP - GENERAL COUNSEL	Exercise / conversion M · derivative	Stock Options (Right to Buy)	7,450	$0.00	$0	29,762
2022-12-08	Furlow Brenda S.	SVP - GENERAL COUNSEL	Open-market sell S	Common Stock	7,450	$82.12	$611,810	26,092
2022-12-08	Furlow Brenda S.	SVP - GENERAL COUNSEL	Exercise / conversion M	Common Stock	7,450	$31.26	$232,906	33,542
2022-12-07	Furlow Brenda S.	SVP - GENERAL COUNSEL	Exercise / conversion M · derivative	Stock Options (Right to Buy)	800	$0.00	$0	37,212
2022-12-07	Furlow Brenda S.	SVP - GENERAL COUNSEL	Open-market sell S	Common Stock	800	$82.01	$65,605	26,092
2022-12-07	Furlow Brenda S.	SVP - GENERAL COUNSEL	Exercise / conversion M	Common Stock	800	$31.26	$25,010	26,892
2022-10-27	HIGGINS JOHN L	—	Equity grant / award A · derivative	Stock Options (Right to Buy)	865	$0.00	$0	865
2022-10-27	HIGGINS JOHN L	—	Equity grant / award A	Common Stock	338	$0.00	$0	5,840
2022-08-23	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M · derivative	Stock Option (Right to Buy)	663	$0.00	$0	6,848
2022-08-23	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M	Common Stock	663	$150.78	$99,967	3,801
2022-08-15	Geist William	PRESIDENT, PROTEIN SCIENCES	Equity grant / award A · derivative	Stock Options (Right to Buy)	7,400	$0.00	$0	7,400
2022-08-15	Geist William	PRESIDENT, PROTEIN SCIENCES	Equity grant / award A · derivative	Stock Options (Right to Buy)	5,550	$0.00	$0	5,550
2022-08-15	Geist William	PRESIDENT, PROTEIN SCIENCES	Equity grant / award A · derivative	Restricted Stock Units	1,785	$0.00	$0	1,785
2022-08-11	HIGGINS JOHN L	Dir	Open-market sell S	Common Stock	8	$380.71	$3,046	5,502
2022-08-11	HIGGINS JOHN L	Dir	Open-market sell S	Common Stock	504	$385.47	$194,277	5,510
2022-08-10	HIGGINS JOHN L	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	3,400	$0.00	$0	0
2022-08-10	HIGGINS JOHN L	Dir	Open-market sell S	Common Stock	992	$380.15	$377,112	6,014
2022-08-10	HIGGINS JOHN L	Dir	Open-market sell S	Common Stock	100	$374.89	$37,490	7,006
2022-08-10	HIGGINS JOHN L	Dir	Open-market sell S	Common Stock	900	$373.99	$336,593	7,106
2022-08-10	HIGGINS JOHN L	Dir	Exercise / conversion M	Common Stock	3,400	$66.90	$227,460	8,006
2022-08-08	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M · derivative	Stock Options (Right to Buy)	563	$0.00	$0	16,562
2022-08-08	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M	Common Stock	563	$177.32	$99,831	6,523
2022-08-07	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M · derivative	Restricted Stock Units	2,363	$0.00	$0	0
2022-08-07	Kelderman Kim	Pres. Diagnostics & Genom	Other disposed transaction F	Common Stock	1,214	$382.97	$464,926	3,138
2022-08-07	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M	Common Stock	2,363	$0.00	$0	4,352
2022-07-28	Kummeth Charles R.	CHIEF EXECUTIVE OFFICER	Exercise / conversion M · derivative	Stock Option (right to buy)	45,346	$0.00	$0	0
2022-07-28	Kummeth Charles R.	CHIEF EXECUTIVE OFFICER	Other disposed transaction F	Common Stock	27,707	$380.76	$10,549,717	235,042
2022-07-28	Kummeth Charles R.	CHIEF EXECUTIVE OFFICER	Exercise / conversion M	Common Stock	45,346	$108.49	$4,919,588	262,749
2022-07-06	Kummeth Charles R.	CHIEF EXECUTIVE OFFICER	Exercise / conversion M · derivative	Stock Option (right to buy)	50,000	$0.00	$0	45,346
2022-07-06	Kummeth Charles R.	CHIEF EXECUTIVE OFFICER	Other disposed transaction F	Common Stock	30,935	$362.78	$11,222,599	217,403
2022-07-06	Kummeth Charles R.	CHIEF EXECUTIVE OFFICER	Exercise / conversion M	Common Stock	50,000	$108.49	$5,424,500	248,338
2022-06-08	HIGGINS JOHN L	—	Exercise / conversion M · derivative	Stock Options (Right to Buy)	600	$0.00	$0	3,400
2022-06-08	HIGGINS JOHN L	—	Open-market sell S	Common Stock	600	$366.09	$219,654	4,606
2022-06-08	HIGGINS JOHN L	—	Exercise / conversion M	Common Stock	600	$66.90	$40,140	5,206
2022-06-07	HIGGINS JOHN L	—	Exercise / conversion M · derivative	Stock Options (Right to Buy)	1,000	$0.00	$0	4,000
2022-06-07	HIGGINS JOHN L	—	Open-market sell S	Common Stock	1,000	$364.31	$364,310	4,606
2022-06-07	HIGGINS JOHN L	—	Exercise / conversion M	Common Stock	1,000	$66.90	$66,900	5,606
2022-05-10	BAUMGARTNER ROBERT V	—	Open-market buy P	Common Stock	300	$352.55	$105,765	10,106
2022-02-08	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,989	$0.00	$0	7,511
2022-02-08	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M	Common Stock	1,989	$150.78	$299,901	1,989
2022-02-01	Geist William	President, Protein Sciences	Equity grant / award A · derivative	Stock Option (right to buy)	3,978	$0.00	$0	3,978
2022-02-01	Geist William	President, Protein Sciences	Equity grant / award A · derivative	Stock Option (right to buy)	2,984	$0.00	$0	2,984
2022-02-01	Geist William	President, Protein Sciences	Equity grant / award A · derivative	Restricted Stock Units	840	$0.00	$0	840
2022-02-01	Geist William	President, Protein Sciences	Equity grant / award A	Common Stock	2,490	$0.00	$0	2,490
2022-02-01	Geist William	President, Protein Sciences	Equity grant / award A · derivative	Restricted Stock Units	2,490	$0.00	$0	2,490
2022-01-28	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	799	$0.00	$0	194,771
2022-01-28	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	938	$0.00	$0	256,010
2022-01-28	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	799	$125.05	$99,915	198,338
2022-01-28	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	938	$106.59	$99,981	197,539
2021-11-19	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M · derivative	Stock Option (Right to Buy)	500	$0.00	$0	2,152
2021-11-19	Kelderman Kim	Pres. Diagnostics & Genom	Open-market sell S	Common Stock	400	$505.78	$202,313	0
2021-11-19	Kelderman Kim	Pres. Diagnostics & Genom	Open-market sell S	Common Stock	100	$503.76	$50,376	400
2021-11-19	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M	Common Stock	500	$150.78	$75,390	500
2021-11-16	Eansor Norman David	President-Protein Sciences	Exercise / conversion M · derivative	Stock Options (Right to Buy)	799	$0.00	$0	0
2021-11-16	Eansor Norman David	President-Protein Sciences	Exercise / conversion M	Common Stock	799	$125.05	$99,915	2,117
2021-11-12	Eansor Norman David	President-Protein Sciences	Exercise / conversion M · derivative	Stock Options (Right to Buy)	27,159	$0.00	$0	799
2021-11-12	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	401	$506.24	$203,002	1,318
2021-11-12	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	2,535	$505.49	$1,281,407	1,719
2021-11-12	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	8,989	$504.39	$4,533,985	4,254
2021-11-12	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	9,043	$503.61	$4,554,137	13,243
2021-11-12	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	4,054	$502.77	$2,038,221	22,286
2021-11-12	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	400	$505.00	$202,002	26,340
2021-11-12	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	537	$504.14	$270,725	26,740
2021-11-12	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	300	$502.99	$150,897	27,277
2021-11-12	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	200	$504.78	$100,956	27,577
2021-11-12	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	700	$504.09	$352,860	27,777
2021-11-12	Eansor Norman David	President-Protein Sciences	Exercise / conversion M	Common Stock	27,159	$125.05	$3,396,233	28,477
2021-11-02	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	200	$0.00	$0	47,389
2021-11-02	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	200	$525.10	$105,020	10,755
2021-11-02	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	200	$125.05	$25,010	10,955
2021-11-01	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	8,822	$0.00	$0	47,589
2021-11-01	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	943	$528.55	$498,427	10,755
2021-11-01	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,433	$527.50	$755,903	11,698
2021-11-01	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	2,880	$526.50	$1,516,321	13,131
2021-11-01	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	3,566	$525.61	$1,874,318	16,011
2021-11-01	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	8,822	$125.05	$1,103,191	19,577
2021-10-28	BAUMGARTNER ROBERT V	Dir	Equity grant / award A · derivative	Stock Options (right to buy)	633	$0.00	$0	633
2021-10-28	BAUMGARTNER ROBERT V	Dir	Equity grant / award A	Common Stock	194	$0.00	$0	9,806
2021-09-22	Kelderman Kim	Pres. Diagnostics & Genom	Open-market sell S	Common Stock	822	$529.04	$434,871	0
2021-09-07	STEER RANDOLPH C	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	4,000	$0.00	$0	0
2021-09-07	STEER RANDOLPH C	Dir	Open-market sell S	Common Stock	500	$511.45	$255,725	5,112
2021-09-07	STEER RANDOLPH C	Dir	Open-market sell S	Common Stock	4,600	$510.23	$2,347,052	5,612
2021-09-07	STEER RANDOLPH C	Dir	Open-market sell S	Common Stock	2,900	$509.33	$1,477,046	10,212
2021-09-07	STEER RANDOLPH C	Dir	Exercise / conversion M	Common Stock	4,000	$91.78	$367,120	13,112
2021-09-02	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	73,492	$0.00	$0	100,450
2021-09-02	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction F	Common Stock	42,005	$510.78	$21,455,314	196,601
2021-09-02	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	73,492	$108.49	$7,973,147	238,606
2021-08-31	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	1,538	$503.07	$773,728	1,318
2021-08-23	Nusse Roeland	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	4,000	$0.00	$0	0
2021-08-23	Nusse Roeland	Dir	Open-market sell S	Common Stock	4,000	$481.52	$1,926,065	6,765
2021-08-23	Nusse Roeland	Dir	Exercise / conversion M	Common Stock	4,000	$70.35	$281,400	10,765
2021-08-19	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M · derivative	Stock Options (Right to Buy)	799	$0.00	$0	8,704
2021-08-19	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M · derivative	Stock Options (Right to Buy)	3,538	$0.00	$0	0
2021-08-19	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	600	$475.05	$285,032	7,620
2021-08-19	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	1,838	$474.12	$871,427	8,220
2021-08-19	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	1,100	$473.08	$520,391	10,058
2021-08-19	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M	Common Stock	799	$125.05	$99,915	11,158
2021-08-19	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M	Common Stock	3,538	$106.59	$377,115	10,359
2021-08-11	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	921	$0.00	$0	173,942
2021-08-11	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	921	$108.49	$99,919	165,114
2021-08-06	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A · derivative	Stock Options (Right to Buy)	20,876	$0.00	$0	20,876
2021-08-06	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A · derivative	Stock Options (Right to Buy)	31,315	$0.00	$0	31,315
2021-08-06	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A · derivative	Restricted Stock Units	8,016	$0.00	$0	8,016
2021-08-06	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Restricted Stock Units	16,918	$0.00	$0	0
2021-08-06	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction F	Common Stock	12,475	$481.82	$6,010,704	164,193
2021-08-06	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	16,918	$0.00	$0	176,668
2021-08-06	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A	Common Stock	5,344	$0.00	$0	159,750
2021-07-12	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	10,000	$0.00	$0	20,000
2021-07-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	100	$466.44	$46,644	9,137
2021-07-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	300	$462.08	$138,625	9,337
2021-07-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	800	$459.64	$367,712	10,237
2021-07-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,863	$458.81	$854,770	11,037
2021-07-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,136	$457.79	$520,055	12,900
2021-07-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	527	$456.41	$240,527	14,036
2021-07-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,773	$455.57	$807,717	14,563
2021-07-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	662	$454.15	$300,647	16,336
2021-07-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	788	$453.21	$357,126	16,998
2021-07-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	751	$451.95	$339,416	17,786
2021-07-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	600	$460.71	$276,428	9,637
2021-07-12	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	10,000	$106.59	$1,065,900	19,137
2021-06-18	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	326	$450.37	$146,821	154,406
2021-06-18	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	2,583	$449.09	$1,159,999	154,732
2021-06-17	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	109	$452.13	$49,282	157,315
2021-06-17	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	1,050	$451.54	$474,117	157,424
2021-06-17	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	1,698	$450.39	$764,762	158,474
2021-06-17	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	6,732	$449.35	$3,025,024	160,172
2021-06-14	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	349	$450.10	$157,085	166,904
2021-06-14	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	7,132	$449.10	$3,202,981	167,253
2021-06-09	Kelderman Kim	Pres. Diagnostics & Genom	Open-market sell S	Common Stock	811	$433.00	$351,163	0
2021-06-07	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	9,942	$0.00	$0	30,000
2021-06-07	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	310	$424.59	$131,623	9,137
2021-06-07	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,700	$423.74	$720,357	9,447
2021-06-07	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	2,000	$422.81	$845,628	11,147
2021-06-07	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	2,396	$421.93	$1,010,935	13,147
2021-06-07	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	2,029	$420.66	$853,523	15,543
2021-06-07	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,507	$419.88	$632,765	17,572
2021-06-07	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	9,942	$106.59	$1,059,718	19,079
2021-05-25	Kelderman Kim	Pres. Diagnostics & Genom	Open-market sell S	Common Stock	845	$424.00	$358,280	811
2021-05-01	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M · derivative	Restricted Stock Units	1,667	$0.00	$0	0
2021-05-01	Kelderman Kim	Pres. Diagnostics & Genom	Other disposed transaction F	Common Stock	856	$427.49	$365,931	1,656
2021-05-01	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M	Common Stock	1,667	—	—	2,512
2021-03-01	Furlow Brenda S.	SVP - General Counsel	Equity grant / award A · derivative	Stock Options (Right to Buy)	10,997	$0.00	$0	10,997
2021-02-16	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	30,000	$0.00	$0	36,849
2021-02-16	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction F	Common Stock	17,428	$411.00	$7,162,908	158,841
2021-02-16	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	30,000	$94.35	$2,830,500	176,269
2021-02-12	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	10,000	$0.00	$0	39,942
2021-02-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	600	$401.52	$240,910	9,137
2021-02-12	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	9,400	$400.32	$3,762,998	9,737
2021-02-12	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	10,000	$106.59	$1,065,900	19,137
2021-02-08	Nusse Roeland	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	5,000	$0.00	$0	0
2021-02-08	Nusse Roeland	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	1,000	$0.00	$0	4,000
2021-02-08	Nusse Roeland	Dir	Open-market sell S	Common Stock	6,000	$385.08	$2,310,481	6,765
2021-02-08	Nusse Roeland	Dir	Exercise / conversion M	Common Stock	5,000	$66.90	$334,500	12,765
2021-02-08	Nusse Roeland	Dir	Exercise / conversion M	Common Stock	1,000	$70.35	$70,350	7,765
2021-02-05	Kelderman Kim	Pres. Diagnostics & Genom	Open-market sell S	Common Stock	823	$388.45	$319,694	845
2021-01-15	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	20,000	$344.00	$6,880,000	146,269
2021-01-11	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	10,000	$0.00	$0	49,942
2021-01-11	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	2,009	$334.98	$672,983	9,137
2021-01-11	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	3,990	$334.39	$1,334,219	11,146
2021-01-11	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	2,501	$333.23	$833,415	15,136
2021-01-11	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	700	$331.61	$232,127	17,637
2021-01-11	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	400	$330.26	$132,106	18,337
2021-01-11	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	10,000	$106.59	$1,065,900	19,137
2020-12-07	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	5,000	$308.00	$1,540,000	166,269
2020-11-30	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M · derivative	Stock Option (Right to Buy)	10,857	$0.00	$0	0
2020-11-30	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M · derivative	Stock Option (Right to Buy)	938	$0.00	$0	13,538
2020-11-30	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	707	$302.82	$214,093	6,124
2020-11-30	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	6,783	$302.15	$2,049,476	6,831
2020-11-30	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	3,367	$301.32	$1,014,558	13,614
2020-11-30	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M	Common Stock	938	$106.59	$99,981	16,981
2020-11-30	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M	Common Stock	10,857	$106.59	$1,157,248	16,043
2020-11-18	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M · derivative	Stock Options (right to buy)	5,000	$0.00	$0	0
2020-11-18	BAUMGARTNER ROBERT V	Dir	Open-market sell S	Common Stock	5,000	$303.33	$1,516,675	9,612
2020-11-18	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M	Common Stock	5,000	$66.90	$334,500	14,612
2020-11-11	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,391	$0.00	$0	59,942
2020-11-09	Seth Alpna	—	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,125	$0.00	$0	0
2020-11-09	Seth Alpna	—	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,898	$0.00	$0	0
2020-11-09	Seth Alpna	—	Open-market sell S	Common Stock	3,665	$306.95	$1,124,972	2,139
2020-11-09	Seth Alpna	—	Open-market sell S	Common Stock	1,358	$305.74	$415,195	5,804
2020-11-09	Seth Alpna	—	Exercise / conversion M	Common Stock	3,125	$125.05	$390,781	7,162
2020-11-09	Seth Alpna	—	Exercise / conversion M	Common Stock	1,898	$179.84	$341,336	4,037
2020-11-06	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	25,157	$0.00	$0	0
2020-11-06	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction F	Common Stock	15,375	$302.47	$4,650,476	171,269
2020-11-06	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	25,157	$86.25	$2,169,791	186,644
2020-11-05	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	100	$293.66	$29,366	9,137
2020-11-05	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	750	$291.06	$218,297	9,237
2020-11-05	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	359	$289.39	$103,890	9,987
2020-11-05	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	3,249	$287.98	$935,648	10,346
2020-11-05	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	121	$287.15	$34,745	13,595
2020-11-05	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,630	$285.12	$464,740	13,716
2020-11-05	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	325	$283.64	$92,183	15,346
2020-11-05	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,674	$282.52	$472,939	15,671
2020-11-05	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	203	$281.27	$57,099	17,345
2020-11-05	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	398	$280.28	$111,550	17,548
2020-11-05	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	8,809	$108.49	$955,688	17,946
2020-11-05	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	8,809	$0.00	$0	0
2020-11-04	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,100	$0.00	$0	7,100
2020-11-04	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,200	$275.79	$330,952	9,137
2020-11-04	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,600	$274.53	$439,254	10,337
2020-11-04	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	2,745	$273.65	$751,157	11,937
2020-11-04	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,555	$272.71	$424,064	14,682
2020-11-04	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	7,100	$108.49	$770,279	16,237
2020-10-29	BAUMGARTNER ROBERT V	—	Equity grant / award A · derivative	Stock Option (Right to Buy)	1,507	$0.00	$0	1,507
2020-10-29	BAUMGARTNER ROBERT V	—	Equity grant / award A	Common Stock	391	$0.00	$0	9,612
2020-10-05	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,809	$0.00	$0	0
2020-08-09	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M · derivative	Restricted Stock Units	1,724	$0.00	$0	0
2020-08-09	Furlow Brenda S.	SVP - General Counsel	Other disposed transaction F	Common Stock	849	$265.76	$225,630	5,186
2020-08-09	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M	Common Stock	1,724	$0.00	$0	6,035
2020-08-05	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A · derivative	Stock Options (Right to Buy)	16,650	$0.00	$0	16,650
2020-08-05	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A · derivative	Stock Options (Right to Buy)	38,295	$0.00	$0	38,295
2020-08-05	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A · derivative	Stock Options (Right to Buy)	57,442	$0.00	$0	57,442
2020-08-05	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A · derivative	Restricted Stock Units	12,879	$0.00	$0	12,879
2020-08-05	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A	Common Stock	8,586	$0.00	$0	152,483
2020-08-03	Bushman Julie L	—	Equity grant / award A · derivative	Stock Option (Right to Buy)	361	$0.00	$0	361
2020-08-03	Bushman Julie L	—	Equity grant / award A	Common Stock	89	$0.00	$0	89
2020-07-09	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M · derivative	Stock Option (Right to Buy)	9,079	$0.00	$0	921
2020-07-09	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	74	$278.84	$20,634	4,311
2020-07-09	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	2,746	$278.06	$763,556	4,385
2020-07-09	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	1,954	$277.28	$541,812	7,131
2020-07-09	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	400	$276.02	$110,410	9,085
2020-07-09	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	918	$274.80	$252,271	9,485
2020-07-09	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	2,042	$273.33	$558,143	10,403
2020-07-09	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	505	$272.48	$137,601	12,445
2020-07-09	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	440	$270.97	$119,225	12,950
2020-07-09	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M	Common Stock	9,079	$108.49	$984,981	13,390
2020-07-07	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	2,577	$0.00	$0	15,909
2020-07-07	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	500	$272.26	$136,130	9,307
2020-07-07	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,663	$271.40	$451,341	9,807
2020-07-07	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	414	$270.56	$112,010	11,470
2020-07-07	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	2,577	$108.49	$279,579	11,884
2020-07-06	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	21,502	$0.00	$0	18,486
2020-07-06	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,269	$274.52	$348,363	9,307
2020-07-06	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,934	$273.71	$529,358	10,576
2020-07-06	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	4,947	$272.34	$1,347,256	12,510
2020-07-06	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	3,781	$271.53	$1,026,667	17,457
2020-07-06	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	9,571	$270.45	$2,588,508	21,238
2020-07-06	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	21,502	$108.49	$2,332,752	30,809
2020-05-29	WIENS HAROLD J	—	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,985	$0.00	$0	0
2020-05-29	WIENS HAROLD J	—	Open-market sell S	Common Stock	3,985	$260.00	$1,036,100	4,843
2020-05-29	WIENS HAROLD J	—	Exercise / conversion M	Common Stock	3,985	$101.19	$403,242	8,828
2020-05-28	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M · derivative	Stock Options (Right to Buy)	5,995	$0.00	$0	10,000
2020-05-28	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M · derivative	Stock Options (Right to Buy)	1,600	$0.00	$0	0
2020-05-28	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	3,800	$260.38	$989,454	4,311
2020-05-28	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	2,195	$259.72	$570,079	8,111
2020-05-28	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M	Common Stock	1,600	$94.35	$150,960	10,306
2020-05-28	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M	Common Stock	5,995	$108.49	$650,398	8,706
2020-05-26	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	21,159	$0.00	$0	25,157
2020-05-26	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction F	Common Stock	13,018	$266.40	$3,467,995	138,130
2020-05-26	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	21,159	$86.25	$1,824,964	151,148
2020-05-22	Eansor Norman David	President-Protein Sciences	Exercise / conversion M · derivative	Stock Options (Right to Buy)	8,637	$0.00	$0	11,357
2020-05-22	Eansor Norman David	President-Protein Sciences	Exercise / conversion M · derivative	Stock Options (Right to Buy)	3,963	$0.00	$0	0
2020-05-22	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	4,924	$268.41	$1,321,636	0
2020-05-22	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	7,676	$267.62	$2,054,290	4,924
2020-05-22	Eansor Norman David	President-Protein Sciences	Exercise / conversion M	Common Stock	8,637	$108.49	$937,028	12,600
2020-05-22	Eansor Norman David	President-Protein Sciences	Exercise / conversion M	Common Stock	3,963	$94.35	$373,909	3,963
2020-05-22	WIENS HAROLD J	—	Equity grant / award G	Common Stock	378	$0.00	$0	4,843
2020-05-21	Eansor Norman David	President-Protein Sciences	Exercise / conversion M · derivative	Stock Options (Right to Buy)	11,037	$0.00	$0	3,963
2020-05-21	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	900	$268.88	$241,996	0
2020-05-21	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	10,137	$267.37	$2,710,320	900
2020-05-21	Eansor Norman David	President-Protein Sciences	Exercise / conversion M	Common Stock	11,037	$94.35	$1,041,341	11,037
2020-05-06	WIENS HAROLD J	—	Exercise / conversion M · derivative	Stock Option (right to buy)	4,260	$0.00	$0	0
2020-05-06	WIENS HAROLD J	—	Open-market sell S	Common Stock	4,260	$250.00	$1,065,000	5,221
2020-05-06	WIENS HAROLD J	—	Exercise / conversion M	Common Stock	4,260	$87.34	$372,068	9,481
2020-05-01	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M · derivative	Restricted Stock Units	1,666	$0.00	$0	1,667
2020-05-01	Kelderman Kim	Pres. Diagnostics & Genom	Other disposed transaction F	Common Stock	821	$227.54	$186,810	1,668
2020-05-01	Kelderman Kim	Pres. Diagnostics & Genom	Exercise / conversion M	Common Stock	1,666	—	—	2,489
2020-04-30	WIENS HAROLD J	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	4,000	$0.00	$0	0
2020-04-30	WIENS HAROLD J	Dir	Open-market sell S	Common Stock	4,000	$225.00	$900,000	5,221
2020-04-30	WIENS HAROLD J	Dir	Exercise / conversion M	Common Stock	4,000	$91.78	$367,120	9,221
2020-03-04	Eansor Norman David	President-Protein Sciences	Open-market sell S	Common Stock	1,387	$198.68	$275,569	0
2020-02-12	HIGGINS JOHN L	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	5,000	$0.00	$0	0
2020-02-12	HIGGINS JOHN L	Dir	Open-market sell S	Common Stock	5,000	$205.23	$1,026,132	4,021
2020-02-12	HIGGINS JOHN L	Dir	Exercise / conversion M	Common Stock	5,000	$61.46	$307,300	9,021
2020-01-06	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	10,276	$0.00	$0	100
2020-01-06	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	10,276	$217.28	$2,232,769	129,989
2020-01-06	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	10,276	$67.46	$693,219	140,265
2020-01-03	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	7,999	$0.00	$0	10,376
2020-01-03	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	1,741	$218.23	$379,938	129,989
2020-01-03	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	6,258	$217.37	$1,360,301	131,730
2020-01-03	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	7,999	$67.46	$539,613	137,988
2020-01-02	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	19,843	$0.00	$0	18,375
2020-01-02	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	92	$221.12	$20,344	129,989
2020-01-02	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	775	$220.28	$170,717	130,081
2020-01-02	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	9,245	$219.32	$2,027,613	130,856
2020-01-02	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	3,282	$218.42	$716,854	140,101
2020-01-02	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	6,449	$217.40	$1,402,013	143,383
2020-01-02	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	19,843	$67.46	$1,338,609	149,832
2019-12-24	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	471	$0.00	$0	38,218
2019-12-24	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	471	$222.18	$104,648	129,989
2019-12-24	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	471	$67.46	$31,774	130,460
2019-12-23	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	659	$0.00	$0	38,689
2019-12-23	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	659	$222.08	$146,351	129,989
2019-12-23	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	659	$67.46	$44,456	130,648
2019-12-20	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	5,767	$0.00	$0	39,348
2019-12-20	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	5,767	$222.06	$1,280,632	129,989
2019-12-20	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	5,767	$67.46	$389,042	135,756
2019-12-12	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M · derivative	Stock Options (Right to Buy)	8,000	$0.00	$0	1,600
2019-12-12	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	200	$216.75	$43,350	2,711
2019-12-12	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	4,147	$216.01	$895,784	2,911
2019-12-12	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	3,227	$215.17	$694,338	7,058
2019-12-12	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	426	$214.32	$91,300	10,285
2019-12-12	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M	Common Stock	8,000	$94.35	$754,800	10,711
2019-12-10	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	703	$0.00	$0	45,115
2019-12-10	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	703	$222.01	$156,073	135,756
2019-12-10	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	703	$67.46	$47,424	136,459
2019-12-04	WIENS HAROLD J	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	2,000	$0.00	$0	0
2019-12-04	WIENS HAROLD J	Dir	Open-market sell S	Common Stock	80	$219.31	$17,545	5,221
2019-12-04	WIENS HAROLD J	Dir	Open-market sell S	Common Stock	921	$218.75	$201,473	5,301
2019-12-04	WIENS HAROLD J	Dir	Open-market sell S	Common Stock	514	$217.29	$111,685	6,222
2019-12-04	WIENS HAROLD J	Dir	Open-market sell S	Common Stock	485	$216.47	$104,990	6,736
2019-12-04	WIENS HAROLD J	Dir	Exercise / conversion M	Common Stock	2,000	$87.83	$175,660	7,221
2019-11-29	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	100	$222.62	$22,262	135,756
2019-11-27	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	11,772	$0.00	$0	45,818
2019-11-27	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	11,772	$222.12	$2,614,814	135,856
2019-11-27	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	11,772	$67.46	$794,139	147,628
2019-11-25	Nusse Roeland	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	5,000	$0.00	$0	0
2019-11-25	Nusse Roeland	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	10,000	$0.00	$0	0
2019-11-25	Nusse Roeland	Dir	Open-market sell S	Common Stock	8,347	$219.33	$1,830,731	12,374
2019-11-25	Nusse Roeland	Dir	Exercise / conversion M	Common Stock	5,000	$61.46	$307,300	20,721
2019-11-25	Nusse Roeland	Dir	Exercise / conversion M	Common Stock	10,000	$60.46	$604,600	15,721
2019-11-22	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	23,651	$0.00	$0	0
2019-11-22	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	1,600	$216.16	$345,850	9,307
2019-11-22	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	22,051	$215.55	$4,753,051	10,907
2019-11-22	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	23,651	$94.35	$2,231,472	32,958
2019-11-21	Hippel James	Chief Financial Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	11,349	$0.00	$0	23,651
2019-11-21	Hippel James	Chief Financial Officer	Open-market sell S	Common Stock	11,349	$215.36	$2,444,132	9,307
2019-11-21	Hippel James	Chief Financial Officer	Exercise / conversion M	Common Stock	11,349	$94.35	$1,070,778	20,656
2019-11-12	Furlow Brenda S.	SVP - General Counsel	Equity grant / award G	Common Stock	492	$0.00	$0	2,711
2019-10-24	KEEGAN JOSEPH D	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	2,011	$0.00	$0	2,011
2019-10-24	KEEGAN JOSEPH D	Dir	Equity grant / award A	Common Stock	495	$0.00	$0	1,748
2019-09-09	Kummeth Charles R.	Chief Executive Officer	Open-market buy P	Common Stock	100	$185.00	$18,500	100
2019-08-19	Eansor Norman David	SVP - Novus Biologicals	Exercise / conversion M · derivative	Restricted Stock Units	2,287	$0.00	$0	0
2019-08-19	Eansor Norman David	SVP - Novus Biologicals	Other disposed transaction F	Common Stock	900	$197.57	$177,813	1,387
2019-08-19	Eansor Norman David	SVP - Novus Biologicals	Exercise / conversion M	Common Stock	2,287	—	—	2,287
2019-08-13	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to Buy)	7,410	$0.00	$0	57,590
2019-08-13	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	7,410	$67.46	$499,879	110,877
2019-08-07	BAUMGARTNER ROBERT V	Dir	Open-market buy P	Common Stock	500	$191.06	$95,530	8,726
2019-07-10	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to buy)	16,969	$0.00	$0	0
2019-07-10	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	494	$214.07	$105,750	92,176
2019-07-10	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	9,909	$213.32	$2,113,768	92,670
2019-07-10	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	6,566	$212.75	$1,396,911	102,579
2019-07-10	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	16,969	$67.46	$1,144,729	109,145
2019-07-09	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to buy)	15,037	$0.00	$0	16,969
2019-07-09	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	15,037	$212.43	$3,194,340	92,176
2019-07-09	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	15,037	$67.46	$1,014,396	107,213
2019-07-08	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Stock Options (Right to buy)	17,994	$0.00	$0	32,006
2019-07-08	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	17,994	$212.75	$3,828,184	92,176
2019-07-08	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	17,994	$67.46	$1,213,875	110,170
2019-07-01	VESSEY RUPERT	—	Equity grant / award A · derivative	Stock Options (Right to buy)	588	$0.00	$0	588
2019-07-01	VESSEY RUPERT	—	Equity grant / award A	Common Stock	147	$0.00	$0	147
2019-07-01	VESSEY RUPERT	Dir	Equity grant / award A · derivative	Stock Options (Right to Buy)	588	$0.00	$0	588
2019-06-12	Eansor Norman David	SVP - Novus Biologicals	Open-market sell S	Common Stock	3,117	$215.00	$670,155	0
2019-06-04	HIGGINS JOHN L	—	Exercise / conversion M · derivative	Stock Options (Right to buy)	5,000	$0.00	$0	0
2019-06-04	HIGGINS JOHN L	—	Open-market sell S	Common Stock	5,000	$203.67	$1,018,346	3,526
2019-06-04	HIGGINS JOHN L	—	Exercise / conversion M	Common Stock	5,000	$63.03	$315,150	8,526
2019-05-24	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M · derivative	Stock Options (Right to buy)	5,400	$0.00	$0	5,400
2019-05-24	Furlow Brenda S.	SVP - General Counsel	Open-market sell S	Common Stock	5,400	$200.00	$1,080,000	2,189
2019-05-24	Furlow Brenda S.	SVP - General Counsel	Exercise / conversion M	Common Stock	5,400	$0.00	$0	7,589
2019-05-01	Kelderman Kim	President, Diagnostics & Genom	Exercise / conversion M · derivative	Restricted Stock	1,667	$0.00	$0	0
2019-05-01	Kelderman Kim	President, Diagnostics & Genom	Other disposed transaction F	Common Stock	844	$202.13	$170,598	823
2019-05-01	Kelderman Kim	President, Diagnostics & Genom	Exercise / conversion M	Common Stock	1,667	$202.13	$336,951	1,667
2018-10-25	STEER RANDOLPH C	—	Equity grant / award A · derivative	Stock Option (right to buy)	1,898	$0.00	$0	1,898
2018-10-25	STEER RANDOLPH C	—	Equity grant / award A	Common Stock	514	$0.00	$0	4,226
2018-08-24	BAUMGARTNER ROBERT V	—	Exercise / conversion M · derivative	Stock Options (Right to buy)	5,000	$0.00	$0	0
2018-08-24	BAUMGARTNER ROBERT V	—	Open-market sell S	Common Stock	5,000	$188.47	$942,334	7,712
2018-08-24	BAUMGARTNER ROBERT V	—	Exercise / conversion M	Common Stock	5,000	$61.46	$307,300	12,712
2018-08-23	HIGGINS JOHN L	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	10,000	$0.00	$0	0
2018-08-23	HIGGINS JOHN L	Dir	Open-market sell S	Common Stock	10,000	$187.92	$1,879,173	3,012
2018-08-23	HIGGINS JOHN L	Dir	Exercise / conversion M	Common Stock	10,000	$61.08	$610,800	13,012
2018-08-18	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction F	Common Stock	1,338	$180.50	$241,509	92,176
2018-08-08	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A · derivative	Stock Options (Right to buy)	90,334	$0.00	$0	90,334
2018-08-08	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A · derivative	Stock Options (Right to buy)	60,222	$0.00	$0	60,222
2018-08-08	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A · derivative	Restricted Stock Units	16,918	$0.00	$0	16,918
2018-08-08	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A	Common Stock	11,279	$0.00	$0	93,514
2018-08-08	Kelderman Kim	President, Diagnostics & Genom	Equity grant / award A · derivative	Stock Options (Right to buy)	9,033	$0.00	$0	9,033
2018-08-08	Kelderman Kim	President, Diagnostics & Genom	Equity grant / award A · derivative	Stock Options (Right to buy)	12,044	$0.00	$0	12,044
2018-08-08	Kelderman Kim	President, Diagnostics & Genom	Equity grant / award A · derivative	Restricted Stock Units	1,691	$0.00	$0	1,691
2018-08-07	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction D · derivative	Stock Options (Right to buy)	23,929	$0.00	$0	95,346
2018-08-07	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction D · derivative	Restricted Stock Units	3,467	$0.00	$0	0
2018-08-07	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M · derivative	Restricted Stock Units	13,816	$0.00	$0	3,467
2018-08-07	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction F	Common Stock	1,752	$180.14	$315,605	82,235
2018-08-07	Kummeth Charles R.	Chief Executive Officer	Other disposed transaction F	Common Stock	6,301	$180.14	$1,135,062	83,987
2018-08-07	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	13,816	$0.00	$0	90,288
2018-06-07	Kummeth Charles R.	Chief Executive Officer	Open-market sell S	Common Stock	8,000	$160.00	$1,280,000	76,472
2018-05-04	Eansor Norman David	SVP - Novus Biologicals	Open-market sell S	Common Stock	1,136	$145.19	$164,932	2,266
2018-05-01	Kelderman Kim	President, Diagnostics & Genom	Equity grant / award A · derivative	Stock Option (Right to Buy)	7,348	$0.00	$0	10,000
2018-05-01	Kelderman Kim	President, Diagnostics & Genom	Equity grant / award A · derivative	Stock Option (Right to Buy)	2,652	$0.00	$0	2,652
2018-05-01	Kelderman Kim	President, Diagnostics & Genom	Equity grant / award A · derivative	Restricted Stock	5,000	$0.00	$0	5,000
2018-02-13	Dinarello Charles A	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	5,000	$0.00	$0	0
2018-02-13	Dinarello Charles A	Dir	Open-market sell S	Common Stock	2,505	$136.36	$341,582	8,212
2018-02-13	Dinarello Charles A	Dir	Open-market sell S	Common Stock	2,495	$135.76	$338,721	10,717
2018-02-13	Dinarello Charles A	Dir	Exercise / conversion M	Common Stock	5,000	$65.47	$327,350	13,212
2017-11-01	BAUMGARTNER ROBERT V	—	Exercise / conversion M · derivative	Stock Option (Right to buy)	5,000	$0.00	$0	0
2017-11-01	BAUMGARTNER ROBERT V	—	Open-market sell S	Common Stock	5,000	$130.18	$650,907	7,712
2017-11-01	BAUMGARTNER ROBERT V	—	Exercise / conversion M	Common Stock	5,000	$63.03	$315,150	12,712
2017-10-26	KEEGAN JOSEPH D	—	Equity grant / award A · derivative	Stock Options (Right to buy)	3,125	$0.00	$0	3,125
2017-10-26	KEEGAN JOSEPH D	—	Equity grant / award A	Common Stock	739	$0.00	$0	739
2017-10-26	Eansor Norman David	SVP - Novus Biologicals	Equity grant / award A · derivative	Stock Options (Right to buy)	15,976	$0.00	$0	15,976
2017-10-26	Eansor Norman David	SVP - Novus Biologicals	Equity grant / award A · derivative	Stock Options (Right to buy)	11,982	$0.00	$0	11,982
2017-10-26	Eansor Norman David	SVP - Novus Biologicals	Equity grant / award A · derivative	Restricted Stock Units	2,174	$0.00	$0	2,174
2017-10-10	LUCAS ROGER C	—	Open-market sell S	Common Stock	100	$121.95	$12,196	1,870
2017-09-08	LUCAS ROGER C	—	Open-market sell S	Common Stock	100	$120.94	$12,094	1,970
2017-09-06	HOLBROOK KAREN A	—	Open-market sell S	Common Stock	1,059	$121.73	$128,909	914
2017-08-12	Kummeth Charles R.	Chief Executive Officer	Equity grant / award A · derivative	Stock Option (Right to Buy)	66,849	$0.00	$0	66,849
2017-08-12	Kummeth Charles R.	Chief Executive Officer	Exercise / conversion M	Common Stock	9,248	—	—	70,278
2017-08-10	LUCAS ROGER C	—	Open-market sell S	Common Stock	100	$114.30	$11,430	2,070
2017-07-10	LUCAS ROGER C	—	Open-market sell S	Common Stock	100	$116.86	$11,686	2,170
2017-07-09	Gould Kevin S	SVP Clinical Controls	Other disposed transaction F	Common Stock	312	$117.68	$36,716	1,355
2017-07-01	Furlow Brenda S.	SVP - General Counsel	Other disposed transaction F	Common Stock	278	$117.50	$32,665	1,668
2017-06-09	LUCAS ROGER C	—	Open-market sell S	Common Stock	100	$113.62	$11,362	2,270
2017-05-31	Dinarello Charles A	—	Open-market sell S	Common Stock	5,000	$111.37	$556,862	7,473
2017-05-26	Dinarello Charles A	—	Exercise / conversion M · derivative	Stock Options (Right to buy)	5,000	$0.00	$0	0
2017-05-26	Dinarello Charles A	—	Exercise / conversion M	Common Stock	5,000	$66.59	$332,950	12,473
2017-05-25	HOLBROOK KAREN A	—	Exercise / conversion M · derivative	Stock Option (right to buy)	5,000	$0.00	$0	0
2017-05-25	HOLBROOK KAREN A	—	Open-market sell S	Common Stock	5,000	$111.15	$555,773	1,973
2017-05-25	HOLBROOK KAREN A	—	Exercise / conversion M	Common Stock	5,000	$66.59	$332,950	6,973
2017-05-22	LUCAS ROGER C	—	Open-market sell S	Common Stock	1,059	$110.01	$116,505	2,370
2017-05-10	LUCAS ROGER C	—	Open-market sell S	Common Stock	100	$110.59	$11,059	3,429
2017-04-10	LUCAS ROGER C	—	Open-market sell S	Common Stock	78	$101.13	$7,888	3,551
2017-04-10	LUCAS ROGER C	—	Open-market sell S	Common Stock	22	$101.23	$2,227	3,529
2017-03-31	Hippel James	Chief Financial Officer	Other disposed transaction F	Common Stock	800	$101.65	$81,320	3,079
2017-03-10	LUCAS ROGER C	—	Open-market sell S	Common Stock	21	$107.81	$2,264	3,629
2017-03-10	LUCAS ROGER C	—	Open-market sell S	Common Stock	79	$107.76	$8,513	3,650
2017-02-10	LUCAS ROGER C	—	Open-market sell S	Common Stock	100	$102.60	$10,260	3,729
2017-02-01	Gavin Robert M.	Senior V.P. Protein Platforms	Exercise / conversion M · derivative	Restricted Stock Units	1,667	$0.00	$0	0
2017-02-01	Gavin Robert M.	Senior V.P. Protein Platforms	Other disposed transaction D · derivative	Stock Option (Right to Buy)	33,333	$0.00	$0	16,667
2017-02-01	Gavin Robert M.	Senior V.P. Protein Platforms	Exercise / conversion M	Common Stock	1,667	$0.00	$0	1,667
2017-01-10	LUCAS ROGER C	—	Open-market sell S	Common Stock	100	$103.57	$10,357	3,829
2016-12-09	LUCAS ROGER C	Dir	Open-market sell S	Common Stock	100	$108.92	$10,892	3,929
2016-11-29	HOLBROOK KAREN A	Dir	Open-market sell S	Common Stock	1,000	$106.73	$106,733	1,973
2016-11-16	LUCAS ROGER C	Dir	Open-market sell S	Common Stock	100	$105.75	$10,575	4,029
2016-10-27	LUCAS ROGER C	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	3,985	$0.00	$0	3,985
2016-10-27	LUCAS ROGER C	Dir	Equity grant / award A	Common Stock	914	$0.00	$0	4,129
2016-10-27	BAUMGARTNER ROBERT V	Dir	Equity grant / award A · derivative	Stock Option (right to buy)	3,985	$0.00	$0	3,985
2016-10-27	BAUMGARTNER ROBERT V	Dir	Equity grant / award A	Common Stock	914	$0.00	$0	6,973
2016-10-19	LUCAS ROGER C	Dir	Open-market sell S	Common Stock	100	$104.71	$10,471	3,215
2016-09-21	LUCAS ROGER C	Dir	Open-market sell S	Common Stock	100	$108.91	$10,891	3,315
2016-09-08	Gould Kevin S	SVP Clinical Controls	Open-market sell S	Common Stock	524	$110.50	$57,904	1,667
2016-09-02	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	2,613	$0.00	$0	0
2016-09-02	BAUMGARTNER ROBERT V	Dir	Open-market sell S	Common Stock	2,613	$107.15	$279,987	6,059
2016-09-02	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M	Common Stock	2,613	$65.47	$171,073	8,672
2016-09-01	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	1,467	$0.00	$0	0
2016-09-01	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	2,387	$0.00	$0	2,613
2016-09-01	BAUMGARTNER ROBERT V	Dir	Open-market sell S	Common Stock	3,854	$107.17	$413,052	6,059
2016-09-01	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M	Common Stock	1,467	$66.59	$97,688	9,913
2016-09-01	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M	Common Stock	2,387	$65.47	$156,277	8,446
2016-08-24	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M · derivative	Stock Option (right to buy)	3,533	$0.00	$0	1,467
2016-08-24	BAUMGARTNER ROBERT V	Dir	Open-market sell S	Common Stock	3,533	$107.10	$378,378	6,059
2016-08-24	BAUMGARTNER ROBERT V	Dir	Exercise / conversion M	Common Stock	3,533	$66.59	$235,262	9,592
2016-08-18	Bazan J. Fernando	Chief Technical Officer	Equity grant / award A · derivative	Restricted Stock Units	1,759	$0.00	$0	1,759
2016-08-18	Bazan J. Fernando	Chief Technical Officer	Equity grant / award A · derivative	Stock Option (Right to Buy)	10,857	$0.00	$0	10,857
2016-08-18	Bazan J. Fernando	Chief Technical Officer	Equity grant / award A · derivative	Stock Option (Right to Buy)	14,476	$0.00	$0	14,476
2016-08-18	Gavin Robert M.	Senior V.P. Protein Platforms	Equity grant / award A · derivative	Restricted Stock Units	2,111	$0.00	$0	2,111
2016-08-18	Gavin Robert M.	Senior V.P. Protein Platforms	Equity grant / award A · derivative	Stock Option (Right to Buy)	13,028	$0.00	$0	13,028
2016-08-18	Gavin Robert M.	Senior V.P. Protein Platforms	Equity grant / award A · derivative	Stock Option (Right to Buy)	17,371	$0.00	$0	17,371
2016-08-17	LUCAS ROGER C	Dir	Open-market sell S	Common Stock	100	$113.70	$11,370	3,415
2016-07-20	LUCAS ROGER C	—	Open-market sell S	Common Stock	100	$111.03	$11,103	3,615
2016-07-09	Gould Kevin S	SVP Clinical Controls	Other disposed transaction F	Common Stock	309	$115.17	$35,588	2,191
2016-07-01	Furlow Brenda S.	SVP - General Counsel	Other disposed transaction F	Common Stock	277	$112.24	$31,090	1,946
2016-06-15	LUCAS ROGER C	—	Open-market sell S	Common Stock	100	$112.15	$11,215	3,715
2016-05-18	LUCAS ROGER C	—	Open-market sell S	Common Stock	100	$102.53	$10,253	3,815
2016-05-09	Dinarello Charles A	—	Open-market sell S	Common Stock	5,000	$101.91	$509,550	6,559
2016-05-06	LUCAS ROGER C	—	Open-market sell S	Common Stock	500	$100.24	$50,120	3,915
2016-05-05	Dinarello Charles A	—	Exercise / conversion M · derivative	Stock Options (Right to Buy)	5,000	$0.00	$0	0
2016-05-05	Dinarello Charles A	—	Exercise / conversion M	Common Stock	5,000	$56.17	$280,850	11,559
2016-04-20	LUCAS ROGER C	Dir	Open-market sell S	Common Stock	100	$92.40	$9,240	4,315

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count