Financial Metrics

TFX TELEFLEX INC

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-27	1.04	—	USD/shares	10-Q	2017-05-04
Quarterly	2016-06-26	1.26	+21.2%	USD/shares	10-Q	2017-08-03
Quarterly	2016-09-25	1.4	+11.1%	USD/shares	10-Q	2017-11-02
Quarterly	2017-04-02	0.86	-38.6%	USD/shares	10-Q	2018-05-03
Quarterly	2017-07-02	1.67	+94.2%	USD/shares	10-Q	2018-08-02
Quarterly	2017-10-01	1.65	-1.2%	USD/shares	10-Q	2018-11-01
Quarterly	2018-04-01	1.2	-27.3%	USD/shares	10-Q	2019-05-02
Quarterly	2018-07-01	-0.05	-104.2%	USD/shares	10-Q	2019-08-01
Quarterly	2018-09-30	1.21	+2520.0%	USD/shares	10-Q	2019-10-31
Quarterly	2019-03-31	0.87	-28.1%	USD/shares	10-Q	2020-04-30
Quarterly	2019-06-30	1.77	+103.4%	USD/shares	10-Q	2020-07-30
Quarterly	2019-09-29	4.85	+174.0%	USD/shares	10-Q	2020-10-29
Quarterly	2020-03-29	2.78	-42.7%	USD/shares	10-Q	2021-04-29
Quarterly	2020-06-28	0.24	-91.4%	USD/shares	10-Q	2021-07-29
Quarterly	2020-09-27	2.46	+925.0%	USD/shares	10-Q	2021-10-28
Quarterly	2021-03-28	1.58	-35.8%	USD/shares	10-Q	2022-04-28
Quarterly	2021-06-27	1.76	+11.4%	USD/shares	10-Q	2022-07-28
Quarterly	2021-09-26	4.2	+138.6%	USD/shares	10-Q	2022-10-27
Quarterly	2022-03-27	1.63	-61.2%	USD/shares	10-Q	2023-05-04
Quarterly	2022-06-26	2.23	+36.8%	USD/shares	10-Q	2023-08-03
Quarterly	2022-09-25	2.16	-3.1%	USD/shares	10-Q	2023-11-03
Quarterly	2023-04-02	1.62	-25.0%	USD/shares	10-Q	2024-05-03
Quarterly	2023-07-02	2.35	+45.1%	USD/shares	10-Q	2024-08-02
Quarterly	2023-10-01	2.9	+23.4%	USD/shares	10-Q	2024-10-31
Quarterly	2024-03-31	0.32	-89.0%	USD/shares	10-Q	2025-05-01
Quarterly	2024-06-30	1.69	+428.1%	USD/shares	10-Q	2025-07-31
Quarterly	2024-09-29	2.36	+39.6%	USD/shares	10-Q	2025-11-06
Quarterly	2025-03-30	2.07	-12.3%	USD/shares	10-Q	2025-05-01
Quarterly	2025-06-29	2.77	+33.8%	USD/shares	10-Q	2025-07-31
Quarterly	2025-09-28	-9.24	-433.6%	USD/shares	10-Q	2025-11-06
Annual	2016-12-31	4.98	—	USD/shares	10-K	2019-02-21
Annual	2017-12-31	3.27	-34.3%	USD/shares	10-K	2020-02-21
Annual	2018-12-31	4.29	+31.2%	USD/shares	10-K	2021-02-25
Annual	2019-12-31	9.8	+128.4%	USD/shares	10-K	2022-03-01
Annual	2020-12-31	7.09	-27.7%	USD/shares	10-K	2023-02-23
Annual	2021-12-31	10.23	+44.3%	USD/shares	10-K	2024-02-23
Annual	2022-12-31	7.68	-24.9%	USD/shares	10-K	2025-02-28
Annual	2023-12-31	7.53	-2.0%	USD/shares	10-K	2026-02-27
Annual	2024-12-31	-2.93	-138.9%	USD/shares	10-K	2026-02-27
Annual	2025-12-31	-16.15	-451.2%	USD/shares	10-K	2026-02-27

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-27	1063171000.0	—	USD	10-Q	2016-04-28
Quarterly	2016-06-26	1081882000.0	+1.8%	USD	10-Q	2016-07-28
Quarterly	2016-09-25	1031862000.0	-4.6%	USD	10-Q	2016-10-27
Quarterly	2016-12-31	1033323000.0	+0.1%	USD	10-Q	2017-11-02
Quarterly	2017-04-02	2088892000.0	+102.2%	USD	10-Q	2017-05-04
Quarterly	2017-07-02	1999755000.0	-4.3%	USD	10-Q	2017-08-03
Quarterly	2017-10-01	2250055000.0	+12.5%	USD	10-Q	2017-11-02
Quarterly	2017-12-31	2162927000.0	-3.9%	USD	10-Q	2018-11-01
Quarterly	2018-04-01	2154217000.0	-0.4%	USD	10-Q	2018-05-03
Quarterly	2018-07-01	2145468000.0	-0.4%	USD	10-Q	2018-08-02
Quarterly	2018-09-30	2075834000.0	-3.2%	USD	10-Q	2018-11-01
Quarterly	2018-12-31	2158825000.0	+4.0%	USD	10-Q	2019-10-31
Quarterly	2019-03-31	2072939000.0	-4.0%	USD	10-Q	2019-05-02
Quarterly	2019-06-30	2131372000.0	+2.8%	USD	10-Q	2019-08-01
Quarterly	2019-09-29	1999068000.0	-6.2%	USD	10-Q	2019-10-31
Quarterly	2019-12-31	1908943000.0	-4.5%	USD	10-Q	2020-10-29
Quarterly	2020-03-29	2394517000.0	+25.4%	USD	10-Q	2020-04-30
Quarterly	2020-06-28	2411791000.0	+0.7%	USD	10-Q	2020-07-30
Quarterly	2020-09-27	2127573000.0	-11.8%	USD	10-Q	2020-10-29
Quarterly	2020-12-31	2478388000.0	+16.5%	USD	10-Q	2021-10-28
Quarterly	2021-03-28	2295436000.0	-7.4%	USD	10-Q	2021-04-29
Quarterly	2021-06-27	2308166000.0	+0.6%	USD	10-Q	2021-07-29
Quarterly	2021-09-26	2049916000.0	-11.2%	USD	10-Q	2021-10-28
Quarterly	2021-12-31	1740102000.0	-15.1%	USD	10-Q	2022-10-27
Quarterly	2022-03-27	1740778000.0	+0.0%	USD	10-Q	2022-04-28
Quarterly	2022-06-26	1605954000.0	-7.7%	USD	10-Q	2022-07-28
Quarterly	2022-09-25	1593504000.0	-0.8%	USD	10-Q	2022-10-27
Quarterly	2022-12-31	1711523000.0	+7.4%	USD	10-Q	2023-11-03
Quarterly	2023-04-02	1549474000.0	-9.5%	USD	10-Q	2023-05-04
Quarterly	2023-07-02	1470674000.0	-5.1%	USD	10-Q	2023-08-03
Quarterly	2023-10-01	2037623000.0	+38.6%	USD	10-Q	2023-11-03
Quarterly	2023-12-31	1727572000.0	-15.2%	USD	10-Q	2024-10-31
Quarterly	2024-03-31	1667896000.0	-3.5%	USD	10-Q	2024-05-03
Quarterly	2024-06-30	1624222000.0	-2.6%	USD	10-Q	2024-08-02
Quarterly	2024-09-29	1661546000.0	+2.3%	USD	10-Q	2024-10-31
Quarterly	2024-12-31	1655871000.0	-0.3%	USD	10-Q	2025-11-06
Quarterly	2025-03-30	1907321000.0	+15.2%	USD	10-Q	2025-05-01
Quarterly	2025-06-29	1901645000.0	-0.3%	USD	10-Q	2025-07-31
Quarterly	2025-09-28	2671504000.0	+40.5%	USD	10-Q	2025-11-06
Annual	2016-12-31	1033323000.0	—	USD	10-K	2018-02-22
Annual	2017-12-31	2249552000.0	+117.7%	USD	10-K	2019-02-21
Annual	2018-12-31	2158825000.0	-4.0%	USD	10-K	2020-02-21
Annual	2019-12-31	1908943000.0	-11.6%	USD	10-K	2021-02-25
Annual	2020-12-31	2478388000.0	+29.8%	USD	10-K	2022-03-01
Annual	2021-12-31	1850102000.0	-25.4%	USD	10-K	2023-02-23
Annual	2022-12-31	1711523000.0	-7.5%	USD	10-K	2024-02-23
Annual	2023-12-31	1815072000.0	+6.1%	USD	10-K	2025-02-28
Annual	2024-12-31	1655871000.0	-8.8%	USD	10-K	2026-02-27
Annual	2025-12-31	2641449000.0	+59.5%	USD	10-K	2026-02-27

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-27	7822000.0	—	USD	10-Q	2017-05-04
Quarterly	2016-06-26	19535000.0	+149.7%	USD	10-Q	2017-08-03
Quarterly	2016-09-25	35912000.0	+83.8%	USD	10-Q	2017-11-02
Quarterly	2017-04-02	12894000.0	-64.1%	USD	10-Q	2018-05-03
Quarterly	2017-07-02	36833000.0	+185.7%	USD	10-Q	2018-08-02
Quarterly	2017-10-01	53977000.0	+46.5%	USD	10-Q	2018-11-01
Quarterly	2018-04-01	15747000.0	-70.8%	USD	10-Q	2019-05-02
Quarterly	2018-07-01	38004000.0	+141.3%	USD	10-Q	2019-08-01
Quarterly	2018-09-30	55751000.0	+46.7%	USD	10-Q	2019-10-31
Quarterly	2019-03-31	23494000.0	-57.9%	USD	10-Q	2020-04-30
Quarterly	2019-06-30	56107000.0	+138.8%	USD	10-Q	2020-07-30
Quarterly	2019-09-29	83797000.0	+49.4%	USD	10-Q	2020-10-29
Quarterly	2020-03-29	19684000.0	-76.5%	USD	10-Q	2021-04-29
Quarterly	2020-06-28	39052000.0	+98.4%	USD	10-Q	2021-07-29
Quarterly	2020-09-27	62369000.0	+59.7%	USD	10-Q	2021-10-28
Quarterly	2021-03-28	19276000.0	-69.1%	USD	10-Q	2022-04-28
Quarterly	2021-06-27	36659000.0	+90.2%	USD	10-Q	2022-07-28
Quarterly	2021-09-26	52090000.0	+42.1%	USD	10-Q	2022-10-27
Quarterly	2022-03-27	13078000.0	-74.9%	USD	10-Q	2023-05-04
Quarterly	2022-06-26	32445000.0	+148.1%	USD	10-Q	2023-08-03
Quarterly	2022-09-25	52648000.0	+62.3%	USD	10-Q	2023-11-03
Quarterly	2023-04-02	21835000.0	-58.5%	USD	10-Q	2024-05-03
Quarterly	2023-07-02	39374000.0	+80.3%	USD	10-Q	2024-08-02
Quarterly	2023-10-01	63768000.0	+62.0%	USD	10-Q	2024-10-31
Quarterly	2024-03-31	38432000.0	-39.7%	USD	10-Q	2025-05-01
Quarterly	2024-06-30	73232000.0	+90.5%	USD	10-Q	2025-07-31
Quarterly	2024-09-29	94412000.0	+28.9%	USD	10-Q	2025-11-06
Quarterly	2025-03-30	30011000.0	-68.2%	USD	10-Q	2025-05-01
Quarterly	2025-06-29	64639000.0	+115.4%	USD	10-Q	2025-07-31
Quarterly	2025-09-28	94585000.0	+46.3%	USD	10-Q	2025-11-06
Annual	2016-12-31	53135000.0	—	USD	10-K	2019-02-21
Annual	2017-12-31	70903000.0	+33.4%	USD	10-K	2020-02-21
Annual	2018-12-31	80795000.0	+14.0%	USD	10-K	2021-02-25
Annual	2019-12-31	102695000.0	+27.1%	USD	10-K	2022-03-01
Annual	2020-12-31	90694000.0	-11.7%	USD	10-K	2023-02-23
Annual	2021-12-31	71618000.0	-21.0%	USD	10-K	2024-02-23
Annual	2022-12-31	79190000.0	+10.6%	USD	10-K	2025-02-28
Annual	2023-12-31	46421000.0	-41.4%	USD	10-K	2026-02-27
Annual	2024-12-31	90437000.0	+94.8%	USD	10-K	2026-02-27
Annual	2025-12-31	95236000.0	+5.3%	USD	10-K	2026-02-27

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-27	48782000.0	—	shares	10-Q	2017-05-04
Quarterly	2016-06-26	47246000.0	-3.1%	shares	10-Q	2017-08-03
Quarterly	2016-09-25	47446000.0	+0.4%	shares	10-Q	2017-11-02
Quarterly	2017-04-02	46615000.0	-1.8%	shares	10-Q	2018-05-03
Quarterly	2017-07-02	46818000.0	+0.4%	shares	10-Q	2018-08-02
Quarterly	2017-10-01	46587000.0	-0.5%	shares	10-Q	2018-11-01
Quarterly	2018-04-01	46695000.0	+0.2%	shares	10-Q	2019-05-02
Quarterly	2018-07-01	45581000.0	-2.4%	shares	10-Q	2019-08-01
Quarterly	2018-09-30	46815000.0	+2.7%	shares	10-Q	2019-10-31
Quarterly	2019-03-31	46942000.0	+0.3%	shares	10-Q	2020-04-30
Quarterly	2019-06-30	47036000.0	+0.2%	shares	10-Q	2020-07-30
Quarterly	2019-09-29	47176000.0	+0.3%	shares	10-Q	2020-10-29
Quarterly	2020-03-29	47231000.0	+0.1%	shares	10-Q	2021-04-29
Quarterly	2020-06-28	47242000.0	+0.0%	shares	10-Q	2021-07-29
Quarterly	2020-09-27	47333000.0	+0.2%	shares	10-Q	2021-10-28
Quarterly	2021-03-28	47407000.0	+0.2%	shares	10-Q	2022-04-28
Quarterly	2021-06-27	47433000.0	+0.1%	shares	10-Q	2022-07-28
Quarterly	2021-09-26	47452000.0	+0.0%	shares	10-Q	2022-10-27
Quarterly	2022-03-27	47402000.0	-0.1%	shares	10-Q	2023-05-04
Quarterly	2022-06-26	47347000.0	-0.1%	shares	10-Q	2023-08-03
Quarterly	2022-09-25	47263000.0	-0.2%	shares	10-Q	2023-11-03
Quarterly	2023-04-02	47285000.0	+0.0%	shares	10-Q	2024-05-03
Quarterly	2023-07-02	47329000.0	+0.1%	shares	10-Q	2024-08-02
Quarterly	2023-10-01	47299000.0	-0.1%	shares	10-Q	2024-10-31
Quarterly	2024-03-31	47394000.0	+0.2%	shares	10-Q	2025-05-01
Quarterly	2024-06-30	47361000.0	-0.1%	shares	10-Q	2025-07-31
Quarterly	2024-09-29	47012000.0	-0.7%	shares	10-Q	2025-11-06
Quarterly	2025-03-30	45926000.0	-2.3%	shares	10-Q	2025-05-01
Quarterly	2025-06-29	44332000.0	-3.5%	shares	10-Q	2025-07-31
Quarterly	2025-09-28	44237000.0	-0.2%	shares	10-Q	2025-11-06
Annual	2016-12-31	47646000.0	—	shares	10-K	2019-02-21
Annual	2017-12-31	46664000.0	-2.1%	shares	10-K	2020-02-21
Annual	2018-12-31	46801000.0	+0.3%	shares	10-K	2021-02-25
Annual	2019-12-31	47090000.0	+0.6%	shares	10-K	2022-03-01
Annual	2020-12-31	47287000.0	+0.4%	shares	10-K	2023-02-23
Annual	2021-12-31	47427000.0	+0.3%	shares	10-K	2024-02-23
Annual	2022-12-31	47309000.0	-0.2%	shares	10-K	2025-02-28
Annual	2023-12-31	47304000.0	-0.0%	shares	10-K	2026-02-27
Annual	2024-12-31	47094000.0	-0.4%	shares	10-K	2026-02-27
Annual	2025-12-31	44724000.0	-5.0%	shares	10-K	2026-02-27

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

2,641,449,000

Total Liabilities (latest annual)

3,822,471,000

Current Liabilities (latest annual)

762,026,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-27	0.0247	—	ratio	10-Q	2017-05-04
Quarterly	2016-06-26	0.0281	+13.8%	ratio	10-Q	2017-08-03
Quarterly	2016-09-25	0.0306	+8.8%	ratio	10-Q	2017-11-02
Quarterly	2017-04-02	0.0181	-40.8%	ratio	10-Q	2018-05-03
Quarterly	2017-07-02	0.0331	+82.7%	ratio	10-Q	2018-08-02
Quarterly	2017-10-01	0.0311	-5.8%	ratio	10-Q	2018-11-01
Quarterly	2018-04-01	0.0219	-29.6%	ratio	10-Q	2019-10-31
Quarterly	2018-07-01	-0.0010	-104.7%	ratio	10-Q	2019-10-31
Quarterly	2018-09-30	0.0225	+2298.6%	ratio	10-Q	2019-10-31
Quarterly	2019-03-31	0.0159	-29.4%	ratio	10-Q	2020-10-29
Quarterly	2019-06-30	0.0313	+96.6%	ratio	10-Q	2020-10-29
Quarterly	2019-09-29	0.0802	+156.5%	ratio	10-Q	2020-10-29
Quarterly	2020-03-29	0.0427	-46.8%	ratio	10-Q	2021-10-28
Quarterly	2020-06-28	0.0037	-91.3%	ratio	10-Q	2021-10-28
Quarterly	2020-09-27	0.0360	+874.0%	ratio	10-Q	2021-10-28
Quarterly	2021-03-28	0.0222	-38.4%	ratio	10-Q	2022-10-27
Quarterly	2021-06-27	0.0240	+8.3%	ratio	10-Q	2022-10-27
Quarterly	2021-09-26	0.0545	+126.7%	ratio	10-Q	2022-10-27
Quarterly	2022-03-27	0.0203	-62.7%	ratio	10-Q	2023-11-03
Quarterly	2022-06-26	0.0274	+34.8%	ratio	10-Q	2023-11-03
Quarterly	2022-09-25	0.0262	-4.5%	ratio	10-Q	2023-11-03
Quarterly	2023-04-02	0.0187	-28.6%	ratio	10-Q	2024-10-31
Quarterly	2023-07-02	0.0264	+41.5%	ratio	10-Q	2024-10-31
Quarterly	2023-10-01	0.0318	+20.4%	ratio	10-Q	2024-10-31
Quarterly	2024-03-31	0.0034	-89.3%	ratio	10-Q	2025-11-06
Quarterly	2024-06-30	0.0176	+417.1%	ratio	10-Q	2025-11-06
Quarterly	2024-09-29	0.0248	+41.1%	ratio	10-Q	2025-11-06
Quarterly	2025-03-30	0.0232	-6.3%	ratio	10-Q	2025-11-06
Quarterly	2025-06-29	0.0289	+24.5%	ratio	10-Q	2025-11-06
Quarterly	2025-09-28	-0.1070	-470.3%	ratio	10-Q	2025-11-06
Annual	2016-12-31	0.1113	—	ratio	10-K	2019-02-21
Annual	2017-12-31	0.0628	-43.6%	ratio	10-K	2020-02-21
Annual	2018-12-31	0.0791	+26.0%	ratio	10-K	2021-02-25
Annual	2019-12-31	0.1549	+95.9%	ratio	10-K	2022-03-01
Annual	2020-12-31	0.1005	-35.1%	ratio	10-K	2023-02-23
Annual	2021-12-31	0.1293	+28.6%	ratio	10-K	2024-02-23
Annual	2022-12-31	0.0903	-30.2%	ratio	10-K	2025-02-28
Annual	2023-12-31	0.0802	-11.1%	ratio	10-K	2026-02-27
Annual	2024-12-31	-0.0319	-139.8%	ratio	10-K	2026-02-27
Annual	2025-12-31	-0.2286	-615.7%	ratio	10-K	2026-02-27

8-K Material Event Details

46 filings · 114 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

742 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-03-04	Logue Daniel V.	CVP, General Counsel & Secty	Other disposed transaction F	Common Stock	131	$119.18	$15,613	24,653
2026-03-03	Logue Daniel V.	CVP, General Counsel & Secty	Equity grant / award A · derivative	Stock Option / (Right to Buy)	21,510	$0.00	$0	21,510
2026-03-03	Logue Daniel V.	CVP, General Counsel & Secty	Equity grant / award A	Common Stock	6,591	$0.00	$0	24,784
2026-03-03	Logue Daniel V.	CVP, General Counsel & Secty	Equity grant / award A	Common Stock	3,262	$0.00	$0	18,193
2026-02-28	Deren John	Executive Vice President & CFO	Other disposed transaction F	Common Stock	231	$122.06	$28,196	4,518
2026-02-23	Hicks Cameron P	Corp. VP & Chief HR Officer	Equity grant / award A	Common Stock	352	$0.00	$0	11,760
2026-01-13	RANDLE STUART A	Interim President and CEO	Equity grant / award A	Common Stock	12,325	$0.00	$0	19,872
2025-08-06	HAGGERTY GRETCHEN R	Dir	Open-market buy P	Common Stock	300	$114.73	$34,419	6,305
2025-08-06	HAGGERTY GRETCHEN R	Dir	Open-market buy P	Common Stock	200	$114.78	$22,956	6,005
2025-08-05	RANDLE STUART A	Dir	Open-market buy P	Common Stock	1,000	$115.86	$115,860	7,547
2025-05-09	Duncan Candace H	Dir	Equity grant / award A · derivative	Stock Option / (Right to Buy)	2,226	$0.00	$0	4,452
2025-05-09	Duncan Candace H	Dir	Equity grant / award A	Common Stock	1,051	$0.00	$0	5,907
2025-05-05	Duncan Candace H	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	4,833	$0.00	$0	0
2025-05-05	Duncan Candace H	Dir	Other disposed transaction F	Common Stock	4,705	$126.41	$594,759	4,856
2025-05-05	Duncan Candace H	Dir	Exercise / conversion M	Common Stock	4,833	$123.04	$594,652	9,561
2025-04-01	POWELL THOMAS E	Executive Vice President & CFO	Other disposed transaction D	Common Stock	655	$0.00	$0	20,812
2025-04-01	POWELL THOMAS E	Executive Vice President & CFO	Other disposed transaction F	Common Stock	468	$140.30	$65,660	21,467
2025-03-04	Deren John	Corp. VP & CAO	Equity grant / award A · derivative	Stock Option / (Right to Buy)	18,896	$0.00	$0	18,896
2025-03-04	Deren John	Corp. VP & CAO	Equity grant / award A	Common Stock	2,676	$0.00	$0	4,588
2025-03-01	Winters James	Corp VP, Mfg and Supply	Other disposed transaction F	Common Stock	434	$132.75	$57,614	3,411
2025-02-24	Winters James	Corp VP, Mfg and Supply	Equity grant / award A	Common Stock	195	$0.00	$0	3,845
2025-02-20	Logue Daniel V.	CVP, General Counsel & Secty	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,620	$0.00	$0	0
2025-02-20	Logue Daniel V.	CVP, General Counsel & Secty	Other disposed transaction F	Common Stock	1,195	$174.82	$208,910	13,133
2025-02-20	Logue Daniel V.	CVP, General Counsel & Secty	Exercise / conversion M	Common Stock	1,620	$121.00	$196,020	14,328
2025-02-19	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	7,380	$0.00	$0	0
2025-02-19	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	29,084	$0.00	$0	0
2025-02-19	Kelly Liam	Chairman, President & CEO	Other disposed transaction F	Common Stock	29,220	$171.29	$5,005,094	34,336
2025-02-19	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	7,380	$123.04	$908,035	63,556
2025-02-19	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	29,084	$121.00	$3,519,164	56,176
2024-08-24	Deren John	Corp. VP & CAO	Other disposed transaction F	Common Stock	16	$242.41	$3,879	1,977
2024-08-16	RANDLE STUART A	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,674	$0.00	$0	0
2024-08-16	RANDLE STUART A	Dir	Open-market sell S	Common Stock	2,674	$238.93	$638,899	5,496
2024-08-16	RANDLE STUART A	Dir	Exercise / conversion M	Common Stock	2,674	$121.00	$323,554	8,170
2024-06-18	Winters James	Corp VP, Mfg and Supply	Equity grant / award A · derivative	Stock Option / (Right to Buy)	1,676	$0.00	$0	1,676
2024-06-18	Winters James	Corp VP, Mfg and Supply	Equity grant / award A	Common Stock	243	$0.00	$0	3,638
2024-05-07	HAGGERTY GRETCHEN R	Dir	Equity grant / award A · derivative	Stock Option / (Right to Buy)	1,349	$0.00	$0	1,349
2024-05-07	HAGGERTY GRETCHEN R	Dir	Equity grant / award A	Common Stock	649	$0.00	$0	4,754
2024-03-02	Deren John	Corp. VP & CAO	Other disposed transaction F	Common Stock	137	$223.00	$30,551	1,988
2024-02-27	Logue Daniel V.	CVP, General Counsel & Secty	Equity grant / award A · derivative	Stock Option / (Right to Buy)	9,332	$0.00	$0	9,332
2024-02-27	Logue Daniel V.	CVP, General Counsel & Secty	Equity grant / award A	Common Stock	1,317	$0.00	$0	12,843
2024-02-27	Logue Daniel V.	CVP, General Counsel & Secty	Equity grant / award A · derivative	Stock Option / (Right to Buy)	9,332	$0.00	$0	9,332
2024-02-27	Logue Daniel V.	CVP, General Counsel & Secty	Equity grant / award A	Common Stock	1,331	$0.00	$0	12,857
2024-02-27	Hicks Cameron P	Corp. VP & Chief HR Officer	Equity grant / award A · derivative	Stock Option / (Right to Buy)	6,999	$0.00	$0	6,999
2024-02-27	Hicks Cameron P	Corp. VP & Chief HR Officer	Equity grant / award A	Common Stock	988	$0.00	$0	10,266
2024-02-27	Winters James	Corp VP, Mfg and Supply	Equity grant / award A · derivative	Stock Option / (Right to Buy)	7,896	$0.00	$0	7,896
2024-02-27	Winters James	Corp VP, Mfg and Supply	Equity grant / award A	Common Stock	1,126	$0.00	$0	3,712
2024-02-26	Logue Daniel V.	CVP, General Counsel & Secty	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,525	$0.00	$0	0
2024-02-26	Logue Daniel V.	CVP, General Counsel & Secty	Other disposed transaction F	Common Stock	752	$228.50	$171,832	11,526
2024-02-26	Logue Daniel V.	CVP, General Counsel & Secty	Exercise / conversion M	Common Stock	1,525	$101.12	$154,208	12,278
2024-02-26	Logue Daniel V.	CVP, General Counsel & Secty	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,525	$0.00	$0	0
2024-02-26	Logue Daniel V.	CVP, General Counsel & Secty	Other disposed transaction F	Common Stock	752	$228.50	$171,832	11,526
2024-02-26	Logue Daniel V.	CVP, General Counsel & Secty	Exercise / conversion M	Common Stock	1,525	$101.12	$154,208	12,278
2024-02-19	Kelly Liam	Chairman, President & CEO	Equity grant / award A	Common Stock	1,856	$0.00	$0	22,037
2023-12-27	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,081	$0.00	$0	0
2023-12-27	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	23,175	$0.00	$0	0
2023-12-27	Kelly Liam	Chairman, President & CEO	Open-market sell S	Common Stock	2,671	$251.16	$670,848	18,470
2023-12-27	Kelly Liam	Chairman, President & CEO	Open-market sell S	Common Stock	23,585	$250.12	$5,899,175	21,141
2023-12-27	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	3,081	$107.47	$331,115	44,726
2023-12-27	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	23,175	$101.12	$2,343,456	41,645
2023-12-21	Kelly Liam	Chairman, President & CEO	Equity grant / award G	Common Stock	5,786	$0.00	$0	19,317
2023-12-13	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,021	$0.00	$0	0
2023-12-13	Klasko Stephen K. M.D.	Dir	Other disposed transaction F	Common Stock	1,296	$235.89	$305,713	6,288
2023-12-13	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	3,021	$101.12	$305,484	7,584
2023-11-29	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	4,613	$0.00	$0	0
2023-11-29	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	9,339	$0.00	$0	0
2023-11-29	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,661	$224.13	$372,280	14,384
2023-11-29	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	5,796	$223.35	$1,294,537	16,045
2023-11-29	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	4,629	$222.41	$1,029,536	21,841
2023-11-29	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,866	$221.50	$413,319	26,470
2023-11-29	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	4,613	$123.04	$567,584	28,336
2023-11-29	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	9,339	$121.00	$1,130,019	23,723
2023-08-09	Kelly Liam	Chairman, President & CEO	Equity grant / award G	Common Stock	5,768	$0.00	$0	5,768
2023-05-09	Ryu Jaewon	Dir	Equity grant / award A · derivative	Stock Option / (Right to Buy)	2,152	$0.00	$0	2,152
2023-05-09	Ryu Jaewon	Dir	Equity grant / award A	Common Stock	527	$0.00	$0	527
2023-02-28	Winters James	Corp VP, Mfg and Supply	Equity grant / award A · derivative	Stock Option / (Right to Buy)	6,350	$0.00	$0	6,350
2023-02-28	Winters James	Corp VP, Mfg and Supply	Equity grant / award A	Common Stock	912	$0.00	$0	2,392
2023-02-28	Kelly Liam	Chairman, President & CEO	Equity grant / award A · derivative	Stock Option / (Right to Buy)	46,904	$0.00	$0	46,904
2023-02-28	Kelly Liam	Chairman, President & CEO	Equity grant / award A	Common Stock	6,733	$0.00	$0	25,921
2023-02-25	Winters James	Corp VP, Mfg and Supply	Other disposed transaction F	Common Stock	173	$235.18	$40,686	1,480
2023-02-25	Kelly Liam	Chairman, President & CEO	Other disposed transaction F	Common Stock	1,025	$235.18	$241,060	19,188
2023-01-27	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,014	$0.00	$0	0
2023-01-27	Klasko Stephen K. M.D.	Dir	Other disposed transaction F	Common Stock	967	$244.68	$236,606	3,882
2023-01-27	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	3,014	$78.50	$236,599	4,849
2023-01-11	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	6,040	$0.00	$0	0
2023-01-11	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,579	$0.00	$0	0
2023-01-11	Kelly Liam	Chairman, President & CEO	Other disposed transaction F	Common Stock	2,173	$259.48	$563,850	19,634
2023-01-11	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	3,579	$82.26	$294,409	21,807
2023-01-11	Kelly Liam	Chairman, President & CEO	Other disposed transaction F	Common Stock	3,622	$259.48	$939,837	18,228
2023-01-11	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	6,040	$78.62	$474,865	21,850
2023-01-11	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	6,040	$0.00	$0	0
2023-01-11	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,579	$0.00	$0	0
2023-01-11	Kelly Liam	Chairman, President & CEO	Other disposed transaction F	Common Stock	2,173	$259.48	$563,850	20,192
2023-01-11	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	3,579	$82.26	$294,409	22,365
2023-01-11	Kelly Liam	Chairman, President & CEO	Other disposed transaction F	Common Stock	3,064	$259.48	$795,047	18,786
2023-01-11	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	6,040	$78.62	$474,865	21,850
2022-12-30	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	16,343	$0.00	$0	6,040
2022-12-30	Kelly Liam	Chairman, President & CEO	Open-market sell S	Common Stock	3	$251.00	$753	15,810
2022-12-30	Kelly Liam	Chairman, President & CEO	Open-market sell S	Common Stock	16,340	$250.03	$4,085,490	15,813
2022-12-30	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	16,343	$78.62	$1,284,887	32,153
2022-06-07	RANDLE STUART A	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,014	$0.00	$0	0
2022-06-07	RANDLE STUART A	Dir	Open-market sell S	Common Stock	3,014	$283.31	$853,896	4,320
2022-06-07	RANDLE STUART A	Dir	Exercise / conversion M	Common Stock	3,014	$78.50	$236,599	7,334
2022-05-03	Patil Neena M	Dir	Equity grant / award A · derivative	Stock Option / (Right to Buy)	1,937	$0.00	$0	1,937
2022-05-03	Patil Neena M	Dir	Equity grant / award A	Common Stock	399	$0.00	$0	399
2022-03-01	White Jay	VP & Pres, Global Commercial	Equity grant / award A · derivative	Stock Option / (Right to Buy)	8,138	$0.00	$0	8,138
2022-03-01	White Jay	VP & Pres, Global Commercial	Equity grant / award A	Common Stock	993	$0.00	$0	3,380
2022-02-28	White Jay	VP & Pres, Global Commercial	Other disposed transaction F	Common Stock	132	$343.01	$45,277	2,387
2022-02-28	White Jay	VP & Pres, Global Commercial	Equity grant / award A	Common Stock	4	$0.00	$0	2,519
2021-12-27	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	6,711	$59.96	$402,392	0
2021-12-27	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,276	$59.75	$135,991	0
2021-12-27	Kelly Liam	Chairman, President & CEO	Open-market sell S	Common Stock	8,987	$330.00	$2,965,710	25,775
2021-12-27	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	6,711	$59.96	$402,392	34,762
2021-12-27	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	2,276	$59.75	$135,991	28,051
2021-11-30	Krakauer Andrew A	Dir	Open-market buy P	Common Stock	500	$307.46	$153,732	3,534
2021-11-10	Hicks Cameron P	Corp. VP & Chief HR Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,600	$0.00	$0	3,001
2021-11-10	Hicks Cameron P	Corp. VP & Chief HR Officer	Open-market sell S	Common Stock	3,600	$350.00	$1,260,000	8,604
2021-11-10	Hicks Cameron P	Corp. VP & Chief HR Officer	Exercise / conversion M	Common Stock	3,600	$121.00	$435,600	12,204
2021-08-24	Deren John	Corp. VP & CAO	Equity grant / award A · derivative	Stock Option / (Right to Buy)	325	$0.00	$0	325
2021-08-24	Deren John	Corp. VP & CAO	Equity grant / award A	Common Stock	45	$0.00	$0	1,089
2021-08-18	Kelly Liam	Chairman, President & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	8,987	$59.75	$536,973	2,276
2021-08-18	Kelly Liam	Chairman, President & CEO	Open-market sell S	Common Stock	1,371	$378.92	$519,499	25,775
2021-08-18	Kelly Liam	Chairman, President & CEO	Open-market sell S	Common Stock	1,513	$377.53	$571,203	27,146
2021-08-18	Kelly Liam	Chairman, President & CEO	Open-market sell S	Common Stock	1,051	$376.43	$395,628	28,659
2021-08-18	Kelly Liam	Chairman, President & CEO	Open-market sell S	Common Stock	4,045	$375.32	$1,518,169	29,710
2021-08-18	Kelly Liam	Chairman, President & CEO	Open-market sell S	Common Stock	1,007	$374.85	$377,474	33,755
2021-08-18	Kelly Liam	Chairman, President & CEO	Exercise / conversion M	Common Stock	8,987	$59.75	$536,973	34,762
2021-07-12	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,564	$59.75	$212,949	0
2021-07-12	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	150	$423.95	$63,592	1,424
2021-07-12	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	1,200	$423.39	$508,068	1,574
2021-07-12	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	2,214	$422.00	$934,308	2,774
2021-07-12	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	3,564	$59.75	$212,949	4,988
2021-06-10	Hicks Cameron P	Corp. VP & Chief HR Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,800	$121.00	$217,800	6,601
2021-06-10	Hicks Cameron P	Corp. VP & Chief HR Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,676	$101.12	$169,477	0
2021-06-10	Hicks Cameron P	Corp. VP & Chief HR Officer	Open-market sell S	Common Stock	600	$397.21	$238,326	8,604
2021-06-10	Hicks Cameron P	Corp. VP & Chief HR Officer	Open-market sell S	Common Stock	1,205	$396.30	$477,542	9,204
2021-06-10	Hicks Cameron P	Corp. VP & Chief HR Officer	Open-market sell S	Common Stock	1,671	$395.05	$660,129	10,409
2021-06-10	Hicks Cameron P	Corp. VP & Chief HR Officer	Exercise / conversion M	Common Stock	1,800	$121.00	$217,800	12,080
2021-06-10	Hicks Cameron P	Corp. VP & Chief HR Officer	Exercise / conversion M	Common Stock	1,676	$101.12	$169,477	10,280
2021-06-04	RANDLE STUART A	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,564	$0.00	$0	0
2021-06-04	RANDLE STUART A	Dir	Equity grant / award G	Common Stock	278	$395.80	$110,032	3,921
2021-06-04	RANDLE STUART A	Dir	Open-market sell S	Common Stock	2,384	$395.66	$943,253	4,199
2021-06-04	RANDLE STUART A	Dir	Other disposed transaction F	Common Stock	179	$395.80	$70,848	6,583
2021-06-04	RANDLE STUART A	Dir	Exercise / conversion M	Common Stock	3,564	$59.75	$212,949	6,762
2021-05-04	RANDLE STUART A	Dir	Equity grant / award A · derivative	Stock Option / (Right to Buy)	771	$0.00	$0	771
2021-05-04	RANDLE STUART A	Dir	Equity grant / award A	Common Stock	300	$0.00	$0	3,198
2021-04-23	Winters James	Corp VP, Mfg and Supply	Other disposed transaction F	Common Stock	107	$443.71	$47,477	1,241
2021-03-15	Hicks Cameron P	Corp. VP & Chief HR Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	326	$0.00	$0	8,401
2021-03-15	Hicks Cameron P	Corp. VP & Chief HR Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,000	$0.00	$0	1,676
2021-03-15	Hicks Cameron P	Corp. VP & Chief HR Officer	Open-market sell S	Common Stock	197	$422.47	$83,227	8,604
2021-03-15	Hicks Cameron P	Corp. VP & Chief HR Officer	Open-market sell S	Common Stock	803	$421.66	$338,593	8,801
2021-03-15	Hicks Cameron P	Corp. VP & Chief HR Officer	Open-market sell S	Common Stock	2,000	$420.61	$841,220	9,604
2021-03-15	Hicks Cameron P	Corp. VP & Chief HR Officer	Exercise / conversion M	Common Stock	3,000	$101.12	$303,360	11,604
2021-03-15	Hicks Cameron P	Corp. VP & Chief HR Officer	Exercise / conversion M	Common Stock	326	$121.00	$39,446	8,604
2021-03-02	Kelly Liam	Chairman, President & CEO	Equity grant / award A · derivative	Stock Option / (Right to Buy)	28,902	$0.00	$0	28,902
2021-03-02	Kelly Liam	Chairman, President & CEO	Equity grant / award A	Common Stock	3,694	$0.00	$0	25,775
2021-02-27	Logue Daniel V.	VP, General Counsel, Secretary	Other disposed transaction F	Common Stock	109	$398.12	$43,395	8,672
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	12,336	$0.00	$0	0
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	5,513	$0.00	$0	0
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	402	$0.00	$0	0
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,832	$0.00	$0	0
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,513	$0.00	$0	0
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,400	$0.00	$0	0
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Other disposed transaction F	Common Stock	12,378	$405.06	$5,013,833	29,124
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M	Common Stock	12,336	$121.00	$1,492,656	41,502
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M	Common Stock	5,513	$101.12	$557,475	29,166
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M	Common Stock	402	$82.26	$33,069	23,653
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M	Common Stock	1,832	$78.62	$144,032	23,251
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M	Common Stock	2,513	$59.75	$150,152	21,419
2020-12-28	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M	Common Stock	3,400	$57.78	$196,452	18,906
2020-12-02	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	500	$0.00	$0	8,727
2020-12-02	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	588	$0.00	$0	4,676
2020-12-02	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M	Common Stock	500	$121.00	$60,500	9,245
2020-12-02	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M	Common Stock	588	$101.12	$59,459	8,745
2020-11-30	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,985	$0.00	$0	0
2020-11-30	Hicks Cameron P	Corp. VP, HR & Communications	Open-market sell S	Common Stock	2,985	$371.00	$1,107,435	8,157
2020-11-30	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M	Common Stock	2,985	$85.54	$255,337	11,142
2020-10-26	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	0
2020-10-26	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$361.38	$72,276	1,121
2020-10-26	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$58.25	$11,650	1,321
2020-09-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	200
2020-09-25	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$326.15	$65,230	1,121
2020-09-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$58.25	$11,650	1,321
2020-08-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	400
2020-08-25	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$373.74	$74,748	1,121
2020-08-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$58.25	$11,650	1,321
2020-07-27	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	600
2020-07-27	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$386.35	$77,270	1,121
2020-07-27	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$58.25	$11,650	1,321
2020-06-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	800
2020-06-25	Klasko Stephen K. M.D.	Dir	Equity grant / award A	Common Stock	200	$356.07	$71,214	1,121
2020-06-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$58.25	$11,650	1,321
2020-05-26	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	1,000
2020-05-26	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$375.14	$75,028	1,121
2020-05-26	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$58.25	$11,650	1,321
2020-05-11	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	400	$0.00	$0	5,264
2020-05-11	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	507	$0.00	$0	2,985
2020-05-11	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M	Common Stock	400	$101.12	$40,448	8,157
2020-05-11	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M	Common Stock	507	$85.54	$43,369	7,757
2020-05-09	Deren John	VP & Chief Accounting Officer	Other disposed transaction F	Common Stock	38	$340.30	$12,931	948
2020-05-07	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,400	$0.00	$0	3,492
2020-05-07	Hicks Cameron P	Corp. VP, HR & Communications	Open-market sell S	Common Stock	1,400	$343.57	$480,998	7,250
2020-05-07	Hicks Cameron P	Corp. VP, HR & Communications	Exercise / conversion M	Common Stock	1,400	$85.54	$119,756	8,650
2020-05-05	Klasko Stephen K. M.D.	Dir	Equity grant / award A · derivative	Stock Option / (Right to Buy)	1,187	$0.00	$0	1,187
2020-05-05	Klasko Stephen K. M.D.	Dir	Equity grant / award A	Common Stock	383	$0.00	$0	1,121
2020-04-27	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	1,200
2020-04-27	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$342.26	$68,452	738
2020-04-27	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$58.25	$11,650	938
2020-03-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	1,400
2020-03-25	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$254.75	$50,950	738
2020-03-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$58.25	$11,650	938
2020-02-28	Deren John	VP & Chief Accounting Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	969	$0.00	$0	970
2020-02-28	Deren John	VP & Chief Accounting Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,215	$0.00	$0	0
2020-02-28	Deren John	VP & Chief Accounting Officer	Open-market sell S	Common Stock	2,184	$346.17	$756,035	2,079
2020-02-28	Deren John	VP & Chief Accounting Officer	Exercise / conversion M	Common Stock	969	$253.72	$245,855	4,263
2020-02-28	Deren John	VP & Chief Accounting Officer	Exercise / conversion M	Common Stock	1,215	$191.18	$232,284	3,294
2020-02-28	Deren John	VP & Chief Accounting Officer	Other disposed transaction F	Common Stock	154	$335.02	$51,593	2,079
2020-02-25	Deren John	VP & Chief Accounting Officer	Equity grant / award A · derivative	Stock Option / (Right to Buy)	2,167	$0.00	$0	2,167
2020-02-25	Deren John	VP & Chief Accounting Officer	Equity grant / award A	Common Stock	222	$0.00	$0	2,233
2020-02-18	SMITH BENSON	Dir	Other disposed transaction F	Common Stock	1,106	$376.44	$416,343	47,861
2020-01-27	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	1,800
2020-01-27	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$375.71	$75,142	736
2020-01-27	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$58.25	$11,650	936
2019-12-26	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	0
2019-12-26	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$374.35	$74,870	736
2019-12-26	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$61.34	$12,268	936
2019-11-29	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,000	$0.00	$0	4,892
2019-11-29	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M	Common Stock	1,000	$85.54	$85,540	7,106
2019-11-26	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,300	$0.00	$0	5,892
2019-11-26	Hicks Cameron P	Vice President, Global HR	Open-market sell S	Common Stock	1,300	$350.00	$455,000	6,106
2019-11-26	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M	Common Stock	1,300	$85.54	$111,202	7,406
2019-11-26	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	5,000	$0.00	$0	9,339
2019-11-26	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	4,000	$349.05	$1,396,200	10,697
2019-11-26	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,000	$347.31	$347,310	14,697
2019-11-26	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	5,000	$121.00	$605,000	15,697
2019-11-25	Hicks Cameron P	Vice President, Global HR	Equity grant / award G	Common Stock	270	$0.00	$0	6,106
2019-11-12	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	7,500	$0.00	$0	14,339
2019-11-12	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	5,287	$331.11	$1,750,579	10,697
2019-11-12	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,868	$329.87	$616,197	15,984
2019-11-12	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	345	$328.03	$113,170	17,852
2019-11-12	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	7,500	$121.00	$907,500	18,197
2019-11-04	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	8,481	$0.00	$0	0
2019-11-04	SMITH BENSON	Dir	Open-market sell S	Common Stock	400	$347.76	$139,104	48,809
2019-11-04	SMITH BENSON	Dir	Open-market sell S	Common Stock	113	$346.50	$39,154	49,209
2019-11-04	SMITH BENSON	Dir	Open-market sell S	Common Stock	4,163	$345.89	$1,439,940	49,322
2019-11-04	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,405	$345.03	$829,797	53,485
2019-11-04	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,400	$343.66	$481,124	55,890
2019-11-04	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	8,481	$59.75	$506,740	57,290
2019-10-31	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	17,000	$0.00	$0	8,481
2019-10-31	SMITH BENSON	Dir	Open-market sell S	Common Stock	427	$340.27	$145,297	48,809
2019-10-31	SMITH BENSON	Dir	Open-market sell S	Common Stock	16,573	$340.00	$5,634,820	49,236
2019-10-31	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	17,000	$59.75	$1,015,750	65,809
2019-10-29	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	7,500	$0.00	$0	21,839
2019-10-29	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	3,819	$328.05	$1,252,823	10,697
2019-10-29	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	3,216	$326.96	$1,051,503	14,516
2019-10-29	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	465	$325.36	$151,292	17,732
2019-10-29	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	7,500	$121.00	$907,500	18,197
2019-10-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	400
2019-10-25	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$316.01	$63,201	736
2019-10-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$61.34	$12,268	936
2019-10-15	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	658	$0.00	$0	29,339
2019-10-15	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	6,842	$0.00	$0	0
2019-10-15	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	5,490	$328.93	$1,805,826	10,697
2019-10-15	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,051	$327.77	$344,486	16,187
2019-10-15	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	759	$326.81	$248,049	17,238
2019-10-15	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	200	$324.78	$64,956	17,997
2019-10-15	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	658	$121.00	$79,618	18,197
2019-10-15	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	6,842	$101.12	$691,863	17,539
2019-10-01	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	7,500	$0.00	$0	6,842
2019-10-01	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	2,700	$339.73	$917,271	10,697
2019-10-01	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,300	$338.73	$440,349	13,397
2019-10-01	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,534	$337.50	$517,725	14,697
2019-10-01	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,260	$336.35	$423,801	16,231
2019-10-01	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	627	$335.41	$210,302	17,491
2019-10-01	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	79	$333.57	$26,352	18,118
2019-10-01	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	7,500	$101.12	$758,400	18,197
2019-09-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	600
2019-09-25	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$342.50	$68,500	736
2019-09-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$61.34	$12,268	936
2019-09-23	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	8,500	$0.00	$0	25,481
2019-09-23	SMITH BENSON	Dir	Open-market sell S	Common Stock	8,500	$340.00	$2,890,000	48,809
2019-09-23	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	8,500	$59.75	$507,875	57,309
2019-09-20	SMITH BENSON	Dir	Equity grant / award G	Common Stock	9,520	$0.00	$0	9,520
2019-09-20	SMITH BENSON	Dir	Equity grant / award G	Common Stock	19,030	$0.00	$0	19,030
2019-09-20	SMITH BENSON	Dir	Equity grant / award G	Common Stock	28,550	$0.00	$0	48,809
2019-09-17	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	7,500	$0.00	$0	14,342
2019-09-17	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	4,114	$334.00	$1,374,076	10,697
2019-09-17	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,332	$333.11	$443,703	14,811
2019-09-17	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	554	$332.11	$183,989	16,143
2019-09-17	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,500	$330.00	$495,000	16,697
2019-09-17	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	7,500	$101.12	$758,400	18,197
2019-09-06	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	7,500	$0.00	$0	21,842
2019-09-06	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	100	$357.27	$35,727	10,697
2019-09-06	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,281	$356.36	$456,497	10,797
2019-09-06	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	6,119	$355.32	$2,174,203	12,078
2019-09-06	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	7,500	$101.12	$758,400	18,197
2019-08-26	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	800
2019-08-26	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$361.06	$72,212	736
2019-08-26	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$61.34	$12,268	936
2019-08-15	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,000	$0.00	$0	7,192
2019-08-15	Hicks Cameron P	Vice President, Global HR	Open-market sell S	Common Stock	1,000	$370.00	$370,000	6,376
2019-08-15	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M	Common Stock	1,000	$85.54	$85,540	7,376
2019-08-14	Deren John	VP & Chief Accounting Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	969	$0.00	$0	1,939
2019-08-14	Deren John	VP & Chief Accounting Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	632	$0.00	$0	316
2019-08-14	Deren John	VP & Chief Accounting Officer	Open-market sell S	Common Stock	403	$365.53	$147,309	2,011
2019-08-14	Deren John	VP & Chief Accounting Officer	Open-market sell S	Common Stock	1,601	$364.95	$584,281	2,414
2019-08-14	Deren John	VP & Chief Accounting Officer	Exercise / conversion M	Common Stock	969	$253.72	$245,855	4,015
2019-08-14	Deren John	VP & Chief Accounting Officer	Exercise / conversion M	Common Stock	632	$194.40	$122,861	3,046
2019-07-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	1,000
2019-07-25	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$343.28	$68,656	736
2019-07-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$61.34	$12,268	936
2019-07-17	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	8,500	$0.00	$0	33,981
2019-07-17	SMITH BENSON	Dir	Open-market sell S	Common Stock	6,600	$332.82	$2,196,612	76,800
2019-07-17	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,900	$332.06	$630,914	83,400
2019-07-17	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	8,500	$59.75	$507,875	85,300
2019-07-03	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	8,500	$0.00	$0	42,481
2019-07-03	SMITH BENSON	Dir	Open-market sell S	Common Stock	100	$332.72	$33,272	76,800
2019-07-03	SMITH BENSON	Dir	Open-market sell S	Common Stock	6,200	$332.06	$2,058,772	76,900
2019-07-03	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,200	$331.43	$729,146	83,100
2019-07-03	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	8,500	$59.75	$507,875	85,300
2019-06-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	1,200
2019-06-25	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$332.17	$66,434	736
2019-06-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$61.34	$12,268	936
2019-06-20	Boylan Karen	VP, Global Strategic Projects	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,149	$0.00	$0	1,000
2019-06-20	Boylan Karen	VP, Global Strategic Projects	Open-market sell S	Common Stock	1,149	$333.21	$382,864	2,258
2019-06-20	Boylan Karen	VP, Global Strategic Projects	Exercise / conversion M	Common Stock	1,149	$78.62	$90,334	3,407
2019-06-19	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	8,500	$0.00	$0	50,981
2019-06-19	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,247	$332.09	$746,206	76,800
2019-06-19	SMITH BENSON	Dir	Open-market sell S	Common Stock	712	$331.37	$235,935	79,047
2019-06-19	SMITH BENSON	Dir	Open-market sell S	Common Stock	3,741	$330.47	$1,236,288	79,759
2019-06-19	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,800	$329.41	$592,938	83,500
2019-06-19	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	8,500	$59.75	$507,875	85,300
2019-06-18	RANDLE STUART A	Dir	Equity grant / award G	Common Stock	253	$329.71	$83,417	2,515
2019-06-18	RANDLE STUART A	Dir	Open-market sell S	Common Stock	300	$330.38	$99,116	2,768
2019-06-18	RANDLE STUART A	Dir	Open-market sell S	Common Stock	2,700	$330.32	$891,856	3,068
2019-06-05	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	8,500	$0.00	$0	59,481
2019-06-05	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,810	$296.99	$834,542	76,800
2019-06-05	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,453	$296.12	$726,382	79,610
2019-06-05	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,937	$295.20	$867,002	82,063
2019-06-05	SMITH BENSON	Dir	Open-market sell S	Common Stock	300	$293.59	$88,077	85,000
2019-06-05	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	8,500	$59.75	$507,875	85,300
2019-05-28	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	1,400
2019-05-28	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$295.81	$59,162	736
2019-05-28	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$61.34	$12,268	936
2019-05-22	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	8,500	$0.00	$0	67,981
2019-05-22	SMITH BENSON	Dir	Open-market sell S	Common Stock	890	$295.68	$263,155	76,800
2019-05-22	SMITH BENSON	Dir	Open-market sell S	Common Stock	5,230	$294.79	$1,541,752	77,690
2019-05-22	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,380	$293.65	$698,887	82,920
2019-05-22	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	8,500	$59.75	$507,875	85,300
2019-05-13	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,000	$0.00	$0	8,892
2019-05-13	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M	Common Stock	1,000	$85.54	$85,540	6,376
2019-05-09	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,500	$0.00	$0	9,892
2019-05-09	Hicks Cameron P	Vice President, Global HR	Open-market sell S	Common Stock	1,500	$298.14	$447,217	5,376
2019-05-09	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M	Common Stock	1,500	$85.54	$128,310	6,876
2019-05-08	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	8,500	$0.00	$0	76,481
2019-05-08	SMITH BENSON	Dir	Open-market sell S	Common Stock	6,130	$294.95	$1,808,044	76,800
2019-05-08	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,070	$294.03	$314,612	82,930
2019-05-08	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,300	$292.89	$380,757	84,000
2019-05-08	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	8,500	$59.75	$507,875	85,300
2019-05-07	BABICH GEORGE JR	Dir	Equity grant / award A · derivative	Stock Option / (Right to Buy)	976	$0.00	$0	976
2019-05-07	BABICH GEORGE JR	Dir	Equity grant / award A	Common Stock	432	$0.00	$0	9,509
2019-04-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	1,600
2019-04-25	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$277.14	$55,428	389
2019-04-25	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$61.34	$12,268	589
2019-04-24	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	8,500	$0.00	$0	84,981
2019-04-24	SMITH BENSON	Dir	Open-market sell S	Common Stock	560	$279.22	$156,363	76,453
2019-04-24	SMITH BENSON	Dir	Open-market sell S	Common Stock	4,400	$278.93	$1,227,292	77,013
2019-04-24	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,200	$277.56	$333,072	81,413
2019-04-24	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,400	$276.45	$387,030	82,613
2019-04-24	SMITH BENSON	Dir	Open-market sell S	Common Stock	900	$275.90	$248,310	84,013
2019-04-24	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	8,500	$59.75	$507,875	84,913
2019-04-10	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	8,500	$0.00	$0	93,481
2019-04-10	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,300	$306.79	$705,617	76,413
2019-04-10	SMITH BENSON	Dir	Open-market sell S	Common Stock	3,800	$306.20	$1,163,560	78,713
2019-04-10	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,202	$305.18	$366,826	82,513
2019-04-10	SMITH BENSON	Dir	Open-market sell S	Common Stock	698	$303.92	$212,136	83,715
2019-04-10	SMITH BENSON	Dir	Open-market sell S	Common Stock	500	$302.80	$151,400	84,413
2019-04-10	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	8,500	$59.75	$507,875	84,913
2019-03-28	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	1,800
2019-03-28	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$301.68	$60,336	389
2019-03-28	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$61.34	$12,268	589
2019-03-11	Deren John	VP & Chief Accounting Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	826	$0.00	$0	0
2019-03-11	Deren John	VP & Chief Accounting Officer	Open-market sell S	Common Stock	125	$290.43	$36,303	2,414
2019-03-11	Deren John	VP & Chief Accounting Officer	Exercise / conversion M	Common Stock	826	$121.00	$99,946	2,539
2019-03-08	HEINMILLER JOHN C	Dir	Open-market buy P	Common Stock	750	$285.00	$213,750	1,384
2019-03-07	Deren John	VP & Chief Accounting Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,430	$0.00	$0	1,215
2019-03-07	Deren John	VP & Chief Accounting Officer	Other disposed transaction F	Common Stock	1,902	$285.81	$543,611	1,713
2019-03-07	Deren John	VP & Chief Accounting Officer	Exercise / conversion M	Common Stock	2,430	$191.18	$464,567	3,615
2019-03-07	HEINMILLER JOHN C	Dir	Open-market buy P	Common Stock	500	$285.00	$142,500	634
2019-03-06	Deren John	VP & Chief Accounting Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,124	$0.00	$0	826
2019-03-06	Deren John	VP & Chief Accounting Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,543	$0.00	$0	0
2019-03-06	Deren John	VP & Chief Accounting Officer	Open-market sell S	Common Stock	5,051	$287.18	$1,450,555	1,185
2019-03-06	Deren John	VP & Chief Accounting Officer	Exercise / conversion M	Common Stock	1,124	$121.00	$136,004	6,236
2019-03-06	Deren John	VP & Chief Accounting Officer	Exercise / conversion M	Common Stock	3,543	$144.79	$512,991	5,112
2019-03-01	POWELL THOMAS E	Executive Vice President & CFO	Other disposed transaction F	Common Stock	1,315	$294.51	$387,281	10,697
2019-02-26	Boylan Karen	VP, Global Strategic Projects	Equity grant / award A · derivative	Stock Option / (Right to Buy)	2,762	$0.00	$0	2,762
2019-02-26	Boylan Karen	VP, Global Strategic Projects	Equity grant / award A	Common Stock	310	$0.00	$0	2,528
2019-01-01	HEINMILLER JOHN C	Dir	Equity grant / award A · derivative	Stock Option / (Right to Buy)	2,331	$0.00	$0	2,331
2019-01-01	HEINMILLER JOHN C	Dir	Equity grant / award A	Common Stock	134	$0.00	$0	134
2018-12-27	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	5,324	$0.00	$0	1,700
2018-12-27	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	15	$248.47	$3,727	8,451
2018-12-27	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	209	$247.21	$51,667	8,466
2018-12-27	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	200	$245.13	$49,026	8,675
2018-12-27	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	100	$243.74	$24,374	8,875
2018-12-27	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	900	$242.74	$218,466	8,975
2018-12-27	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	2,900	$241.88	$701,452	9,875
2018-12-27	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,000	$241.03	$241,030	12,775
2018-12-27	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	5,324	$78.62	$418,573	13,775
2018-12-21	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	100	$0.00	$0	7,024
2018-12-21	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	100	$240.23	$24,023	8,451
2018-12-21	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	100	$78.62	$7,862	8,551
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	5,200	$0.00	$0	5,424
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,700	$262.50	$446,250	10,151
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	200	$260.96	$52,192	11,851
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,244	$258.75	$321,885	12,051
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	798	$257.60	$205,565	13,295
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,258	$256.77	$323,017	14,093
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	5,200	$78.62	$408,824	15,351
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,500	$0.00	$0	7,124
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,700	$262.50	$446,250	8,451
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	200	$260.96	$52,192	10,151
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,244	$258.75	$321,885	10,351
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	798	$257.60	$205,565	11,595
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,258	$256.77	$323,017	12,393
2018-12-07	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	3,500	$78.62	$275,170	13,651
2018-11-23	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	5,200	$0.00	$0	10,624
2018-11-23	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,100	$255.60	$281,160	10,151
2018-11-23	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,700	$254.46	$432,582	11,251
2018-11-23	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,114	$253.62	$282,533	12,951
2018-11-23	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,286	$252.76	$325,049	14,065
2018-11-23	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	5,200	$78.62	$408,824	15,351
2018-11-09	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	5,200	$0.00	$0	15,824
2018-11-09	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	500	$266.45	$133,225	10,151
2018-11-09	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	2,200	$265.41	$583,902	10,651
2018-11-09	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,800	$264.28	$475,704	12,851
2018-11-09	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	700	$263.19	$184,233	14,651
2018-11-09	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	5,200	$78.62	$408,824	15,351
2018-11-08	RANDLE STUART A	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,500	$0.00	$0	0
2018-11-08	RANDLE STUART A	Dir	Open-market sell S	Common Stock	100	$265.24	$26,524	5,421
2018-11-08	RANDLE STUART A	Dir	Open-market sell S	Common Stock	2,400	$265.23	$636,545	5,521
2018-11-08	RANDLE STUART A	Dir	Exercise / conversion M	Common Stock	2,500	$42.75	$106,875	7,921
2018-10-30	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	5,200	$0.00	$0	21,024
2018-10-30	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	5,200	$240.00	$1,248,000	10,151
2018-10-30	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	5,200	$78.62	$408,824	15,351
2018-10-29	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	9,332	$0.00	$0	0
2018-10-29	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,792	$239.19	$428,628	68,556
2018-10-29	SMITH BENSON	Dir	Open-market sell S	Common Stock	4,626	$238.26	$1,102,191	70,348
2018-10-29	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,183	$237.32	$518,070	74,974
2018-10-29	SMITH BENSON	Dir	Open-market sell S	Common Stock	731	$236.19	$172,655	77,157
2018-10-29	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	9,332	$57.78	$539,203	77,888
2018-10-12	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	5,200	$0.00	$0	26,224
2018-10-12	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	452	$249.55	$112,797	10,151
2018-10-12	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,348	$248.66	$335,194	10,603
2018-10-12	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	700	$247.19	$173,033	11,951
2018-10-12	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,100	$246.23	$270,853	12,651
2018-10-12	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	500	$244.23	$122,115	14,851
2018-10-12	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	5,200	$78.62	$408,824	15,351
2018-10-08	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	9,331	$0.00	$0	9,332
2018-10-08	SMITH BENSON	Dir	Open-market sell S	Common Stock	3,308	$252.36	$834,807	68,556
2018-10-08	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,392	$251.53	$350,130	71,864
2018-10-08	SMITH BENSON	Dir	Open-market sell S	Common Stock	999	$250.30	$250,050	73,256
2018-10-08	SMITH BENSON	Dir	Open-market sell S	Common Stock	600	$248.46	$149,076	74,255
2018-10-08	SMITH BENSON	Dir	Open-market sell S	Common Stock	3,032	$247.88	$751,572	74,855
2018-10-08	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	9,331	$57.78	$539,145	77,887
2018-09-28	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,992	$0.00	$0	31,424
2018-09-28	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,208	$0.00	$0	0
2018-09-28	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	100	$268.16	$26,816	10,151
2018-09-28	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,700	$267.47	$454,699	10,251
2018-09-28	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,300	$266.24	$346,112	11,951
2018-09-28	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	2,100	$265.36	$557,256	13,251
2018-09-28	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	1,992	$78.62	$156,611	15,351
2018-09-28	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	3,208	$59.81	$191,870	13,359
2018-09-19	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,007	$0.00	$0	6,015
2018-09-19	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	7,580	$0.00	$0	3,791
2018-09-19	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	6,865	$0.00	$0	0
2018-09-19	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,354	$0.00	$0	0
2018-09-19	Kennedy Thomas Anthony	Senior VP, Global Operations	Open-market sell S	Common Stock	20,635	$268.91	$5,548,958	2,863
2018-09-19	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M	Common Stock	3,007	$191.18	$574,878	23,498
2018-09-19	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M	Common Stock	7,580	$144.79	$1,097,508	20,491
2018-09-19	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M	Common Stock	6,865	$121.00	$830,665	12,911
2018-09-19	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M	Common Stock	2,354	$101.12	$238,036	6,046
2018-09-17	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	9,331	$0.00	$0	18,663
2018-09-17	SMITH BENSON	Dir	Open-market sell S	Common Stock	100	$269.01	$26,901	68,556
2018-09-17	SMITH BENSON	Dir	Open-market sell S	Common Stock	9,031	$266.68	$2,408,387	68,856
2018-09-17	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	9,331	$57.78	$539,145	77,887
2018-09-14	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,919	$0.00	$0	3,208
2018-09-14	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,281	$0.00	$0	0
2018-09-14	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	200	$270.84	$54,168	10,151
2018-09-14	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	2,700	$270.24	$729,648	10,351
2018-09-14	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,400	$269.45	$377,230	13,051
2018-09-14	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	900	$267.84	$241,056	14,451
2018-09-14	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	2,919	$59.81	$174,585	15,351
2018-09-14	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	2,281	$59.75	$136,290	12,432
2018-08-31	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	4,628	$0.00	$0	2,281
2018-08-31	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	572	$0.00	$0	0
2018-08-31	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	400	$248.93	$99,572	10,151
2018-08-31	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,200	$248.06	$297,672	10,551
2018-08-31	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	3,600	$247.23	$890,028	11,751
2018-08-31	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	4,628	$59.75	$276,523	15,351
2018-08-31	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	572	$56.00	$32,032	10,723
2018-08-27	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	9,331	$0.00	$0	27,994
2018-08-27	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,100	$248.96	$273,856	68,556
2018-08-27	SMITH BENSON	Dir	Open-market sell S	Common Stock	3,550	$247.85	$879,868	69,656
2018-08-27	SMITH BENSON	Dir	Open-market sell S	Common Stock	4,681	$247.27	$1,157,471	73,206
2018-08-27	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	9,331	$57.78	$539,145	77,887
2018-08-20	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	5,200	$0.00	$0	572
2018-08-20	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	5,200	$240.02	$1,248,104	10,151
2018-08-20	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	5,200	$56.00	$291,200	15,351
2018-08-08	Krakauer Andrew A	Dir	Open-market buy P	Common Stock	500	$238.39	$119,197	1,502
2018-08-06	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	9,331	$0.00	$0	37,325
2018-08-06	SMITH BENSON	Dir	Open-market sell S	Common Stock	431	$244.91	$105,556	68,556
2018-08-06	SMITH BENSON	Dir	Open-market sell S	Common Stock	4,000	$243.23	$972,920	68,987
2018-08-06	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,100	$241.31	$265,441	72,987
2018-08-06	SMITH BENSON	Dir	Open-market sell S	Common Stock	3,800	$240.17	$912,646	74,087
2018-08-06	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	9,331	$57.78	$539,145	77,887
2018-08-03	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	826	$0.00	$0	29,997
2018-08-03	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	743	$0.00	$0	29,342
2018-08-03	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,631	$0.00	$0	5,772
2018-08-03	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	600	$249.45	$149,670	10,951
2018-08-03	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,900	$248.21	$471,599	11,551
2018-08-03	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,100	$246.72	$271,392	13,451
2018-08-03	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	800	$250.28	$200,224	10,151
2018-08-03	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	826	$121.00	$99,946	15,351
2018-08-03	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	743	$101.12	$75,132	14,525
2018-08-03	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	3,631	$56.00	$203,336	13,782
2018-07-20	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	245	$0.00	$0	30,085
2018-07-20	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,271	$0.00	$0	33,416
2018-07-20	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,673	$0.00	$0	6,909
2018-07-20	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,011	$0.00	$0	9,403
2018-07-20	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	2,200	$277.70	$610,940	10,151
2018-07-20	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,900	$276.96	$526,224	12,351
2018-07-20	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,100	$275.95	$303,545	14,251
2018-07-20	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	245	$101.12	$24,774	15,351
2018-07-20	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	1,271	$78.62	$99,926	15,106
2018-07-20	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	1,673	$59.75	$99,962	13,835
2018-07-20	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	2,011	$56.00	$112,616	12,162
2018-07-16	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	9,331	$0.00	$0	46,656
2018-07-16	SMITH BENSON	Dir	Open-market sell S	Common Stock	131	$274.54	$35,965	68,556
2018-07-16	SMITH BENSON	Dir	Open-market sell S	Common Stock	788	$272.78	$214,951	68,687
2018-07-16	SMITH BENSON	Dir	Open-market sell S	Common Stock	8,412	$271.96	$2,287,728	69,475
2018-07-16	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	9,331	$57.78	$539,145	77,887
2018-07-06	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,344	$0.00	$0	11,414
2018-07-06	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	100	$274.46	$27,446	10,151
2018-07-06	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	3,400	$273.69	$930,546	10,251
2018-07-06	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,700	$272.92	$463,964	13,651
2018-07-06	POWELL THOMAS E	Executive Vice President & CFO	Exercise / conversion M	Common Stock	3,344	$56.00	$187,264	15,351
2018-06-25	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	9,331	$0.00	$0	55,987
2018-06-25	SMITH BENSON	Dir	Open-market sell S	Common Stock	31	$281.64	$8,731	68,556
2018-06-25	SMITH BENSON	Dir	Open-market sell S	Common Stock	200	$279.18	$55,836	68,587
2018-06-25	SMITH BENSON	Dir	Open-market sell S	Common Stock	300	$275.82	$82,746	68,787
2018-06-25	SMITH BENSON	Dir	Open-market sell S	Common Stock	8,800	$275.19	$2,421,672	69,087
2018-06-25	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	9,331	$57.78	$539,145	77,887
2018-06-22	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	100	$283.67	$28,367	12,007
2018-06-22	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	2,400	$282.56	$678,144	12,107
2018-06-22	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	1,500	$281.70	$422,550	14,507
2018-06-22	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	600	$280.49	$168,294	16,007
2018-06-22	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	300	$279.33	$83,799	16,607
2018-06-22	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	176	$277.70	$48,875	16,907
2018-06-22	POWELL THOMAS E	Executive Vice President & CFO	Open-market sell S	Common Stock	124	$276.58	$34,296	17,083
2018-06-12	Deren John	VP & Chief Accounting Officer	Open-market sell S	Common Stock	1,347	$284.57	$383,317	1,419
2018-06-11	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	9,331	$0.00	$0	65,318
2018-06-11	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,981	$283.90	$562,406	68,556
2018-06-11	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,716	$282.70	$767,813	70,537
2018-06-11	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,921	$281.72	$822,904	73,253
2018-06-11	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,713	$281.00	$481,353	76,174
2018-06-11	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	9,331	$57.78	$539,145	77,887
2018-05-22	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,000	$0.00	$0	14,392
2018-05-22	Hicks Cameron P	Vice President, Global HR	Open-market sell S	Common Stock	2,000	$267.00	$534,000	5,014
2018-05-22	Hicks Cameron P	Vice President, Global HR	Exercise / conversion M	Common Stock	2,000	$85.54	$171,080	7,014
2018-05-21	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	9,331	$0.00	$0	74,649
2018-05-21	SMITH BENSON	Dir	Open-market sell S	Common Stock	4,731	$265.70	$1,257,027	68,556
2018-05-21	SMITH BENSON	Dir	Open-market sell S	Common Stock	4,600	$264.81	$1,218,126	73,287
2018-05-21	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	9,331	$57.78	$539,145	77,887
2018-05-16	Klasko Stephen K. M.D.	Dir	Equity grant / award A · derivative	Stock Option / (Right to Buy)	1,131	$0.00	$0	1,131
2018-05-16	Klasko Stephen K. M.D.	Dir	Equity grant / award A	Common Stock	389	$0.00	$0	8,269
2018-05-07	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,000	$0.00	$0	0
2018-05-07	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	275	$0.00	$0	0
2018-05-07	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	2,275	$271.59	$617,867	8,583
2018-05-07	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	2,000	$46.12	$92,240	10,858
2018-05-07	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	275	$58.25	$16,019	8,858
2018-05-04	POWELL THOMAS E	Executive Vice President & CFO	Other disposed transaction F	Common Stock	124	$271.09	$33,615	17,207
2018-04-23	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,725	$0.00	$0	275
2018-04-23	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	775	$0.00	$0	0
2018-04-23	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	2,500	$270.66	$676,650	8,583
2018-04-23	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	1,725	$58.25	$100,481	11,083
2018-04-23	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	775	$59.75	$46,306	9,358
2018-04-16	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	9,331	$0.00	$0	93,311
2018-04-16	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,000	$261.61	$523,220	68,167
2018-04-16	SMITH BENSON	Dir	Open-market sell S	Common Stock	6,000	$260.36	$1,562,160	70,167
2018-04-16	SMITH BENSON	Dir	Open-market sell S	Common Stock	1,331	$259.57	$345,488	76,167
2018-04-16	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	9,331	$57.78	$539,145	77,498
2018-04-09	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,500	$0.00	$0	775
2018-04-09	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	2,500	$246.87	$617,175	8,583
2018-04-09	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	2,500	$59.75	$149,375	11,083
2018-04-02	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,000	$0.00	$0	0
2018-04-02	SMITH BENSON	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	5,331	$0.00	$0	102,642
2018-04-02	SMITH BENSON	Dir	Open-market sell S	Common Stock	15	$254.97	$3,825	78,380
2018-04-02	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,685	$253.50	$680,648	78,395
2018-04-02	SMITH BENSON	Dir	Open-market sell S	Common Stock	2,600	$252.46	$656,396	81,080
2018-04-02	SMITH BENSON	Dir	Open-market sell S	Common Stock	800	$250.12	$200,096	83,680
2018-04-02	SMITH BENSON	Dir	Open-market sell S	Common Stock	3,231	$249.37	$805,714	84,480
2018-04-02	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	2,000	$61.34	$122,680	87,711
2018-04-02	SMITH BENSON	Dir	Exercise / conversion M	Common Stock	5,331	$57.78	$308,025	83,711
2018-03-26	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	289	$0.00	$0	3,275
2018-03-26	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,000	$0.00	$0	0
2018-03-26	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	211	$0.00	$0	0
2018-03-26	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	2,500	$254.53	$636,325	8,583
2018-03-26	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	289	$59.75	$17,268	11,083
2018-03-26	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	2,000	$61.34	$122,680	10,794
2018-03-26	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	211	$78.50	$16,564	8,794
2018-03-12	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,500	$0.00	$0	211
2018-03-12	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	2,500	$268.53	$671,325	8,583
2018-03-12	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	2,500	$78.50	$196,250	11,083
2018-02-28	Deren John	VP & Chief Accounting Officer	Open-market sell S	Common Stock	343	$253.04	$86,794	2,766
2018-02-27	Deren John	VP & Chief Accounting Officer	Equity grant / award A · derivative	Stock Option / (Right to Buy)	2,908	$0.00	$0	2,908
2018-02-27	Deren John	VP & Chief Accounting Officer	Equity grant / award A	Common Stock	346	$0.00	$0	3,109
2018-02-27	Deren John	VP & Chief Accounting Officer	Open-market sell S	Common Stock	1,016	$256.55	$260,655	2,763
2018-02-26	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,197	$0.00	$0	0
2018-02-26	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	303	$0.00	$0	2,711
2018-02-26	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	2,197	$255.67	$561,707	8,583
2018-02-26	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	2,197	$101.12	$222,161	10,780
2018-02-26	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	303	$255.17	$77,317	8,583
2018-02-26	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	303	$78.50	$23,786	8,886
2018-02-23	Kelly Liam	President & CEO	Other disposed transaction F	Common Stock	1,205	$255.27	$307,600	14,340
2018-02-12	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	824	$0.00	$0	2,197
2018-02-12	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,676	$0.00	$0	0
2018-02-12	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	900	$254.11	$228,699	8,583
2018-02-12	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	545	$252.36	$137,536	9,483
2018-02-12	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	755	$251.67	$190,011	10,028
2018-02-12	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	300	$250.56	$75,168	10,783
2018-02-12	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	824	$101.12	$83,323	11,083
2018-02-12	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	1,676	$121.00	$202,796	10,259
2018-02-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	0
2018-02-01	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$276.44	$55,288	7,880
2018-02-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$46.12	$9,224	8,080
2018-01-29	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,502	$0.00	$0	0
2018-01-29	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	998	$0.00	$0	1,676
2018-01-29	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	1,502	$283.11	$425,231	8,583
2018-01-29	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	1,502	$157.46	$236,505	10,085
2018-01-29	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	998	$283.11	$282,544	8,583
2018-01-29	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	998	$121.00	$120,758	9,581
2018-01-16	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	500	$0.00	$0	1,502
2018-01-16	BABICH GEORGE JR	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,000	$0.00	$0	0
2018-01-16	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	500	$263.38	$131,690	8,583
2018-01-16	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	500	$157.46	$78,730	9,083
2018-01-16	BABICH GEORGE JR	Dir	Open-market sell S	Common Stock	2,000	$263.38	$526,760	8,583
2018-01-16	BABICH GEORGE JR	Dir	Exercise / conversion M	Common Stock	2,000	$56.25	$112,500	10,583
2018-01-02	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$0.00	$0	200
2018-01-02	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$248.96	$49,792	7,880
2018-01-02	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$46.12	$9,224	8,080
2018-01-01	Krakauer Andrew A	Dir	Equity grant / award A · derivative	Stock Option / (Right to Buy)	2,178	$0.00	$0	2,178
2018-01-01	Krakauer Andrew A	Dir	Equity grant / award A	Common Stock	113	$0.00	$0	113
2017-12-04	SMITH BENSON	Chairman & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,000	$0.00	$0	0
2017-12-04	SMITH BENSON	Chairman & CEO	Open-market sell S	Common Stock	21	$258.26	$5,423	74,634
2017-12-04	SMITH BENSON	Chairman & CEO	Open-market sell S	Common Stock	1,879	$258.12	$485,007	74,655
2017-12-04	SMITH BENSON	Chairman & CEO	Open-market sell S	Common Stock	100	$257.69	$25,769	76,534
2017-12-04	SMITH BENSON	Chairman & CEO	Exercise / conversion M	Common Stock	2,000	$56.25	$112,500	76,634
2017-12-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$46.12	$9,224	400
2017-12-01	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$265.32	$53,064	7,880
2017-12-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$46.12	$9,224	8,080
2017-11-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$46.12	$9,224	600
2017-11-01	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$237.18	$47,436	7,880
2017-11-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$46.12	$9,224	8,080
2017-10-02	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$46.12	$9,224	800
2017-10-02	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$241.88	$48,376	7,880
2017-10-02	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$46.12	$9,224	8,080
2017-09-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$46.12	$9,224	1,000
2017-09-01	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$211.75	$42,350	7,880
2017-09-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$46.12	$9,224	8,080
2017-08-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$46.12	$9,224	1,200
2017-08-01	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$208.41	$41,682	7,880
2017-08-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$46.12	$9,224	8,080
2017-07-28	Boylan Karen	Vice President, Global RA/QA	Other disposed transaction F	Common Stock	95	$210.10	$19,960	2,212
2017-07-03	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$46.12	$9,224	1,400
2017-07-03	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$208.10	$41,620	7,880
2017-07-03	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$46.12	$9,224	8,080
2017-06-21	HAGGERTY GRETCHEN R	Dir	Open-market buy P	Common Stock	1,000	$203.82	$203,818	1,760
2017-06-07	RANDLE STUART A	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,500	$42.75	$106,875	2,500
2017-06-07	RANDLE STUART A	Dir	Open-market sell S	Common Stock	2,300	$205.67	$473,048	5,032
2017-06-07	RANDLE STUART A	Dir	Open-market sell S	Common Stock	100	$205.66	$20,566	7,332
2017-06-07	RANDLE STUART A	Dir	Exercise / conversion M	Common Stock	2,500	$42.75	$106,875	7,532
2017-06-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$46.12	$9,224	1,600
2017-06-01	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$199.93	$39,986	7,880
2017-06-01	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$46.12	$9,224	8,080
2017-05-15	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	200	$46.12	$9,224	1,800
2017-05-15	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	200	$192.04	$38,408	7,880
2017-05-15	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	200	$46.12	$9,224	8,080
2017-05-12	Klasko Stephen K. M.D.	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	5,000	$56.75	$283,750	0
2017-05-12	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	2,400	$193.67	$464,818	7,880
2017-05-12	Klasko Stephen K. M.D.	Dir	Open-market sell S	Common Stock	2,600	$193.57	$503,285	10,280
2017-05-12	Klasko Stephen K. M.D.	Dir	Exercise / conversion M	Common Stock	5,000	$56.75	$283,750	12,880
2017-05-09	Deren John	VP & Chief Accounting Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	988	$101.12	$99,907	0
2017-05-09	Deren John	VP & Chief Accounting Officer	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	1,258	$79.48	$99,986	0
2017-05-09	Deren John	VP & Chief Accounting Officer	Equity grant / award A · derivative	Stock Option / (Right to Buy)	948	$0.00	$0	948
2017-05-09	Deren John	VP & Chief Accounting Officer	Open-market sell S	Common Stock	100	$194.07	$19,407	3,989
2017-05-09	Deren John	VP & Chief Accounting Officer	Open-market sell S	Common Stock	888	$194.09	$172,355	4,089
2017-05-09	Deren John	VP & Chief Accounting Officer	Open-market sell S	Common Stock	1,258	$194.06	$244,129	4,977
2017-05-09	Deren John	VP & Chief Accounting Officer	Exercise / conversion M	Common Stock	988	$101.12	$99,907	6,235
2017-05-09	Deren John	VP & Chief Accounting Officer	Exercise / conversion M	Common Stock	1,258	$79.48	$99,986	5,247
2017-05-09	Deren John	VP & Chief Accounting Officer	Equity grant / award A	Common Stock	108	$0.00	$0	3,989
2017-04-03	Kelly Liam	President & COO	Other disposed transaction F	Common Stock	97	$193.73	$18,792	15,545
2017-02-28	Leyden James J	VP, General Counsel, Secretary	Equity grant / award A · derivative	Stock Option / (Right to Buy)	11,993	$0.00	$0	11,993
2017-02-28	Leyden James J	VP, General Counsel, Secretary	Equity grant / award A	Common Stock	1,384	—	—	11,242
2017-02-28	Boylan Karen	Vice President, Global RA/QA	Equity grant / award A · derivative	Stock Option / (Right to Buy)	3,700	$0.00	$0	3,700
2017-02-28	Boylan Karen	Vice President, Global RA/QA	Equity grant / award A	Common Stock	427	—	—	2,307
2017-02-28	SMITH BENSON	Chairman & CEO	Equity grant / award A · derivative	Stock Option / (Right to Buy)	67,453	$0.00	$0	67,453
2017-02-28	SMITH BENSON	Chairman & CEO	Equity grant / award A	Common Stock	7,785	—	—	74,634
2017-02-27	Leyden James J	VP, General Counsel, Secretary	Other disposed transaction F	Common Stock	193	$192.81	$37,212	9,858
2017-02-27	Boylan Karen	Vice President, Global RA/QA	Other disposed transaction F	Common Stock	267	$192.81	$51,480	1,880
2017-02-26	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,500	$0.00	$0	0
2017-02-26	Leyden James J	VP, General Counsel, Secretary	Other disposed transaction F	Common Stock	1,222	$189.79	$231,923	10,051
2017-02-26	Leyden James J	VP, General Counsel, Secretary	Exercise / conversion M	Common Stock	2,500	$68.25	$170,625	11,273
2017-02-23	BARRON PATRICIA C	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,000	$67.25	$134,500	0
2017-02-23	BARRON PATRICIA C	Dir	Other disposed transaction F	Common Stock	736	$182.98	$134,673	10,693
2017-02-23	BARRON PATRICIA C	Dir	Exercise / conversion M	Common Stock	2,000	$67.25	$134,500	11,429
2017-01-20	SMITH BENSON	Chairman & CEO	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,000	$67.25	$134,500	0
2017-01-20	SMITH BENSON	Chairman & CEO	Other disposed transaction F	Common Stock	1,200	$165.40	$198,480	66,849
2017-01-20	SMITH BENSON	Chairman & CEO	Exercise / conversion M	Common Stock	2,000	$67.25	$134,500	68,049
2016-12-21	BABICH GEORGE JR	Dir	Equity grant / award G	Common Stock	2,855	$0.00	$0	6,749
2016-09-13	HAGGERTY GRETCHEN R	Dir	Equity grant / award A · derivative	Stock Option / (Right to Buy)	3,390	$0.00	$0	3,390
2016-09-13	HAGGERTY GRETCHEN R	Dir	Equity grant / award A	Common Stock	320	—	—	320
2016-08-12	COOK WILLIAM ROLAND	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,564	$59.75	$212,949	0
2016-08-12	COOK WILLIAM ROLAND	Dir	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,000	$58.25	$116,500	0
2016-08-12	COOK WILLIAM ROLAND	Dir	Other disposed transaction F	Common Stock	1,177	$181.03	$213,072	20,195
2016-08-12	COOK WILLIAM ROLAND	Dir	Exercise / conversion M	Common Stock	3,564	$59.75	$212,949	21,372
2016-08-12	COOK WILLIAM ROLAND	Dir	Other disposed transaction F	Common Stock	644	$181.09	$116,622	17,808
2016-08-12	COOK WILLIAM ROLAND	Dir	Other disposed transaction F	Common Stock	1,131	$181.18	$204,915	16,452
2016-08-12	COOK WILLIAM ROLAND	Dir	Other disposed transaction F	Common Stock	1,421	$181.14	$257,400	13,583
2016-08-12	COOK WILLIAM ROLAND	Dir	Exercise / conversion M	Common Stock	2,000	$58.25	$116,500	18,452
2016-06-06	RANDLE STUART A	Dir	Open-market sell S	Common Stock	797	$166.09	$132,378	4,592
2016-05-16	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,432	$121.00	$415,272	6,865
2016-05-16	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	842	$59.75	$50,310	0
2016-05-16	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	2,024	$78.62	$159,127	0
2016-05-16	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	4,707	$101.12	$475,972	2,354
2016-05-16	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M · derivative	Stock Option / (Right to Buy)	3,090	$78.34	$242,071	0
2016-05-16	Kennedy Thomas Anthony	Senior VP, Global Operations	Open-market sell S	Common Stock	15,102	$160.20	$2,419,340	2,893
2016-05-16	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M	Common Stock	3,432	$121.00	$415,272	17,995
2016-05-16	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M	Common Stock	842	$59.75	$50,310	14,563
2016-05-16	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M	Common Stock	2,024	$78.62	$159,127	13,721
2016-05-16	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M	Common Stock	4,707	$101.12	$475,972	11,697
2016-05-16	Kennedy Thomas Anthony	Senior VP, Global Operations	Exercise / conversion M	Common Stock	3,090	$78.34	$242,071	6,990
2016-05-03	Kelly Liam	EVP & Chief Operating Officer	Equity grant / award A · derivative	Stock Option / (Right to Buy)	0	$0.00	—	3,366
2016-05-03	Kelly Liam	EVP & Chief Operating Officer	Equity grant / award A	Common Stock	349	$0.00	$0	13,006

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count