Financial Metrics

VRTX VERTEX PHARMACEUTICALS INC / MA

Range: 2016-01-01 to 2026-04-29

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Financial Statements

Grouped by statement

Income Statement

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-0.17	—	USD/shares	10-Q	2017-04-28
Quarterly	2016-06-30	-0.26	-52.9%	USD/shares	10-Q	2017-07-28
Quarterly	2016-09-30	-0.16	+38.5%	USD/shares	10-Q	2017-10-30
Quarterly	2017-03-31	0.99	+718.7%	USD/shares	10-Q	2018-04-27
Quarterly	2017-06-30	0.07	-92.9%	USD/shares	10-Q	2018-07-26
Quarterly	2017-09-30	-0.41	-685.7%	USD/shares	10-Q	2018-10-25
Quarterly	2018-03-31	0.81	+297.6%	USD/shares	10-Q	2019-05-01
Quarterly	2018-06-30	0.8	-1.2%	USD/shares	10-Q	2019-08-01
Quarterly	2018-09-30	0.5	-37.5%	USD/shares	10-Q	2019-10-31
Quarterly	2019-03-31	1.03	+106.0%	USD/shares	10-Q	2020-05-01
Quarterly	2019-06-30	1.03	+0.0%	USD/shares	10-Q	2020-07-31
Quarterly	2019-09-30	0.22	-78.6%	USD/shares	10-Q	2020-10-30
Quarterly	2020-03-31	2.29	+940.9%	USD/shares	10-Q	2021-04-30
Quarterly	2020-06-30	3.18	+38.9%	USD/shares	10-Q	2021-07-30
Quarterly	2020-09-30	2.53	-20.4%	USD/shares	10-Q	2021-11-03
Quarterly	2021-03-31	2.49	-1.6%	USD/shares	10-Q	2022-05-06
Quarterly	2021-06-30	0.26	-89.6%	USD/shares	10-Q	2022-08-05
Quarterly	2021-09-30	3.28	+1161.5%	USD/shares	10-Q	2022-10-28
Quarterly	2022-03-31	2.96	-9.8%	USD/shares	10-Q	2023-05-02
Quarterly	2022-06-30	3.13	+5.7%	USD/shares	10-Q	2023-08-02
Quarterly	2022-09-30	3.59	+14.7%	USD/shares	10-Q	2023-11-07
Quarterly	2023-03-31	2.69	-25.1%	USD/shares	10-Q	2024-05-07
Quarterly	2023-06-30	3.52	+30.9%	USD/shares	10-Q	2024-08-02
Quarterly	2023-09-30	3.97	+12.8%	USD/shares	10-Q	2024-11-05
Quarterly	2024-03-31	4.21	+6.0%	USD/shares	10-Q	2025-05-06
Quarterly	2024-06-30	-13.92	-430.6%	USD/shares	10-Q	2025-08-05
Quarterly	2024-09-30	4.01	+128.8%	USD/shares	10-Q	2025-11-04
Quarterly	2025-03-31	2.49	-37.9%	USD/shares	10-Q	2025-05-06
Quarterly	2025-06-30	3.99	+60.2%	USD/shares	10-Q	2025-08-05
Quarterly	2025-09-30	4.2	+5.3%	USD/shares	10-Q	2025-11-04
Annual	2016-12-31	-0.46	—	USD/shares	10-K	2019-02-13
Annual	2017-12-31	1.04	+326.1%	USD/shares	10-K	2020-02-13
Annual	2018-12-31	8.09	+677.9%	USD/shares	10-K	2021-02-11
Annual	2019-12-31	4.51	-44.3%	USD/shares	10-K	2022-02-09
Annual	2020-12-31	10.29	+128.2%	USD/shares	10-K	2023-02-10
Annual	2021-12-31	9.01	-12.4%	USD/shares	10-K	2024-02-15
Annual	2022-12-31	12.82	+42.3%	USD/shares	10-K	2025-02-13
Annual	2023-12-31	13.89	+8.3%	USD/shares	10-K	2026-02-13
Annual	2024-12-31	-2.08	-115.0%	USD/shares	10-K	2026-02-13
Annual	2025-12-31	15.32	+836.5%	USD/shares	10-K	2026-02-13

Balance Sheet

Frequency	Period End	Value	% Chg	Unit	Form	Filed

Cash Flow

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	11974000.0	—	USD	10-Q	2017-04-28
Quarterly	2016-06-30	27892000.0	+132.9%	USD	10-Q	2017-07-28
Quarterly	2016-09-30	41775000.0	+49.8%	USD	10-Q	2017-10-30
Quarterly	2017-03-31	11099000.0	-73.4%	USD	10-Q	2018-04-27
Quarterly	2017-06-30	28477000.0	+156.6%	USD	10-Q	2018-07-26
Quarterly	2017-09-30	56437000.0	+98.2%	USD	10-Q	2018-10-25
Quarterly	2018-03-31	29279000.0	-48.1%	USD	10-Q	2019-05-01
Quarterly	2018-06-30	58891000.0	+101.1%	USD	10-Q	2019-08-01
Quarterly	2018-09-30	79803000.0	+35.5%	USD	10-Q	2019-10-31
Quarterly	2019-03-31	18041000.0	-77.4%	USD	10-Q	2020-05-01
Quarterly	2019-06-30	34399000.0	+90.7%	USD	10-Q	2020-07-31
Quarterly	2019-09-30	58690000.0	+70.6%	USD	10-Q	2020-10-30
Quarterly	2020-03-31	19450000.0	-66.9%	USD	10-Q	2021-04-30
Quarterly	2020-06-30	37314000.0	+91.8%	USD	10-Q	2021-07-30
Quarterly	2020-09-30	212109000.0	+468.4%	USD	10-Q	2021-11-03
Quarterly	2021-03-31	70900000.0	-66.6%	USD	10-Q	2022-05-06
Quarterly	2021-06-30	120800000.0	+70.4%	USD	10-Q	2022-08-05
Quarterly	2021-09-30	173200000.0	+43.4%	USD	10-Q	2022-10-28
Quarterly	2022-03-31	63600000.0	-63.3%	USD	10-Q	2023-05-02
Quarterly	2022-06-30	116900000.0	+83.8%	USD	10-Q	2023-08-02
Quarterly	2022-09-30	171100000.0	+46.4%	USD	10-Q	2023-11-07
Quarterly	2023-03-31	42100000.0	-75.4%	USD	10-Q	2024-05-07
Quarterly	2023-06-30	101700000.0	+141.6%	USD	10-Q	2024-08-02
Quarterly	2023-09-30	142300000.0	+39.9%	USD	10-Q	2024-11-05
Quarterly	2024-03-31	68400000.0	-51.9%	USD	10-Q	2025-05-06
Quarterly	2024-06-30	137400000.0	+100.9%	USD	10-Q	2025-08-05
Quarterly	2024-09-30	205100000.0	+49.3%	USD	10-Q	2025-11-04
Quarterly	2025-03-31	40700000.0	-80.2%	USD	10-Q	2025-05-06
Quarterly	2025-06-30	186400000.0	+358.0%	USD	10-Q	2025-08-05
Quarterly	2025-09-30	288200000.0	+54.6%	USD	10-Q	2025-11-04
Annual	2016-12-31	56563000.0	—	USD	10-K	2019-02-13
Annual	2017-12-31	99421000.0	+75.8%	USD	10-K	2020-02-13
Annual	2018-12-31	95449000.0	-4.0%	USD	10-K	2021-02-11
Annual	2019-12-31	75400000.0	-21.0%	USD	10-K	2022-02-09
Annual	2020-12-31	259800000.0	+244.6%	USD	10-K	2023-02-10
Annual	2021-12-31	235000000.0	-9.5%	USD	10-K	2024-02-15
Annual	2022-12-31	204700000.0	-12.9%	USD	10-K	2025-02-13
Annual	2023-12-31	200400000.0	-2.1%	USD	10-K	2026-02-13
Annual	2024-12-31	297700000.0	+48.6%	USD	10-K	2026-02-13
Annual	2025-12-31	437600000.0	+47.0%	USD	10-K	2026-02-13

Share Data

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	243831000.0	—	shares	10-Q	2017-04-28
Quarterly	2016-06-30	244482000.0	+0.3%	shares	10-Q	2017-07-28
Quarterly	2016-09-30	244920000.0	+0.2%	shares	10-Q	2017-10-30
Quarterly	2017-03-31	248700000.0	+1.5%	shares	10-Q	2018-04-27
Quarterly	2017-06-30	251635000.0	+1.2%	shares	10-Q	2018-07-26
Quarterly	2017-09-30	250268000.0	-0.5%	shares	10-Q	2018-10-25
Quarterly	2018-03-31	258526000.0	+3.3%	shares	10-Q	2019-05-01
Quarterly	2018-06-30	258584000.0	+0.0%	shares	10-Q	2019-08-01
Quarterly	2018-09-30	259788000.0	+0.5%	shares	10-Q	2019-10-31
Quarterly	2019-03-31	260175000.0	+0.1%	shares	10-Q	2020-05-01
Quarterly	2019-06-30	259822000.0	-0.1%	shares	10-Q	2020-07-31
Quarterly	2019-09-30	260473000.0	+0.3%	shares	10-Q	2020-10-30
Quarterly	2020-03-31	263515000.0	+1.2%	shares	10-Q	2021-04-30
Quarterly	2020-06-30	263403000.0	-0.0%	shares	10-Q	2021-07-30
Quarterly	2020-09-30	264079000.0	+0.3%	shares	10-Q	2021-11-03
Quarterly	2021-03-31	261900000.0	-0.8%	shares	10-Q	2022-05-06
Quarterly	2021-06-30	261000000.0	-0.3%	shares	10-Q	2022-08-05
Quarterly	2021-09-30	259700000.0	-0.5%	shares	10-Q	2022-10-28
Quarterly	2022-03-31	257900000.0	-0.7%	shares	10-Q	2023-05-02
Quarterly	2022-06-30	258700000.0	+0.3%	shares	10-Q	2023-08-02
Quarterly	2022-09-30	259500000.0	+0.3%	shares	10-Q	2023-11-07
Quarterly	2023-03-31	260300000.0	+0.3%	shares	10-Q	2024-05-07
Quarterly	2023-06-30	260400000.0	+0.0%	shares	10-Q	2024-08-02
Quarterly	2023-09-30	260600000.0	+0.1%	shares	10-Q	2024-11-05
Quarterly	2024-03-31	261100000.0	+0.2%	shares	10-Q	2025-05-06
Quarterly	2024-06-30	258100000.0	-1.1%	shares	10-Q	2025-08-05
Quarterly	2024-09-30	261000000.0	+1.1%	shares	10-Q	2025-11-04
Quarterly	2025-03-31	259500000.0	-0.6%	shares	10-Q	2025-05-06
Quarterly	2025-06-30	258900000.0	-0.2%	shares	10-Q	2025-08-05
Quarterly	2025-09-30	257600000.0	-0.5%	shares	10-Q	2025-11-04
Annual	2016-12-31	244685000.0	—	shares	10-K	2019-02-13
Annual	2017-12-31	253225000.0	+3.5%	shares	10-K	2020-02-13
Annual	2018-12-31	259185000.0	+2.4%	shares	10-K	2021-02-11
Annual	2019-12-31	260700000.0	+0.6%	shares	10-K	2022-02-09
Annual	2020-12-31	263400000.0	+1.0%	shares	10-K	2023-02-10
Annual	2021-12-31	259900000.0	-1.3%	shares	10-K	2024-02-15
Annual	2022-12-31	259100000.0	-0.3%	shares	10-K	2025-02-13
Annual	2023-12-31	260500000.0	+0.5%	shares	10-K	2026-02-13
Annual	2024-12-31	257900000.0	-1.0%	shares	10-K	2026-02-13
Annual	2025-12-31	258000000.0	+0.0%	shares	10-K	2026-02-13

Credit and Bond Coverage

Company-level

Long-Term Debt (latest annual)

N/A

Total Liabilities (latest annual)

6,977,200,000

Current Liabilities (latest annual)

3,861,200,000

Metrics

Frequency	Period End	Value	% Chg	Unit	Form	Filed
Quarterly	2016-03-31	-0.0323	—	ratio	10-Q	2017-04-28
Quarterly	2016-06-30	-0.0309	+4.4%	ratio	10-Q	2017-07-28
Quarterly	2016-09-30	-0.0327	-5.8%	ratio	10-Q	2017-10-30
Quarterly	2017-03-31	0.1483	+553.2%	ratio	10-Q	2018-04-27
Quarterly	2017-06-30	0.0167	-88.7%	ratio	10-Q	2018-07-26
Quarterly	2017-09-30	-0.1615	-1067.6%	ratio	10-Q	2018-10-25
Quarterly	2018-03-31	0.0935	+157.9%	ratio	10-Q	2019-05-01
Quarterly	2018-06-30	0.0760	-18.8%	ratio	10-Q	2019-08-01
Quarterly	2018-09-30	0.0438	-42.4%	ratio	10-Q	2019-10-31
Quarterly	2019-03-31	0.0569	+29.9%	ratio	10-Q	2020-05-01
Quarterly	2019-06-30	0.0527	-7.3%	ratio	10-Q	2020-07-31
Quarterly	2019-09-30	0.0109	-79.2%	ratio	10-Q	2020-10-30
Quarterly	2020-03-31	0.0933	+752.0%	ratio	10-Q	2021-04-30
Quarterly	2020-06-30	0.1114	+19.4%	ratio	10-Q	2021-07-30
Quarterly	2020-09-30	0.0821	-26.3%	ratio	10-Q	2021-11-03
Quarterly	2021-03-31	0.0727	-11.4%	ratio	10-Q	2022-05-06
Quarterly	2021-06-30	0.0073	-90.0%	ratio	10-Q	2022-08-05
Quarterly	2021-09-30	0.0894	+1126.9%	ratio	10-Q	2022-10-28
Quarterly	2022-03-31	0.0699	-21.8%	ratio	10-Q	2023-05-02
Quarterly	2022-06-30	0.0679	-2.8%	ratio	10-Q	2023-08-02
Quarterly	2022-09-30	0.0714	+5.1%	ratio	10-Q	2023-11-07
Quarterly	2023-03-31	0.0485	-32.1%	ratio	10-Q	2024-05-07
Quarterly	2023-06-30	0.0592	+22.1%	ratio	10-Q	2024-08-02
Quarterly	2023-09-30	0.0627	+5.9%	ratio	10-Q	2024-11-05
Quarterly	2024-03-31	0.0593	-5.4%	ratio	10-Q	2025-05-06
Quarterly	2024-06-30	-0.2432	-510.2%	ratio	10-Q	2025-08-05
Quarterly	2024-09-30	0.0669	+127.5%	ratio	10-Q	2025-11-04
Quarterly	2025-03-31	0.0392	-41.4%	ratio	10-Q	2025-05-06
Quarterly	2025-06-30	0.0601	+53.5%	ratio	10-Q	2025-08-05
Quarterly	2025-09-30	0.0625	+4.0%	ratio	10-Q	2025-11-04
Annual	2016-12-31	-0.0628	—	ratio	10-K	2019-02-13
Annual	2017-12-31	0.0449	+171.5%	ratio	10-K	2020-02-13
Annual	2018-12-31	0.4706	+948.8%	ratio	10-K	2021-02-11
Annual	2019-12-31	0.1934	-58.9%	ratio	10-K	2022-02-09
Annual	2020-12-31	0.3122	+61.4%	ratio	10-K	2023-02-10
Annual	2021-12-31	0.2319	-25.7%	ratio	10-K	2024-02-15
Annual	2022-12-31	0.2388	+3.0%	ratio	10-K	2025-02-13
Annual	2023-12-31	0.2059	-13.8%	ratio	10-K	2026-02-13
Annual	2024-12-31	-0.0326	-115.9%	ratio	10-K	2026-02-13
Annual	2025-12-31	0.2118	+748.9%	ratio	10-K	2026-02-13

8-K Material Event Details

42 filings · 71 item records

This 8-K section tracks corporate event disclosures, not insider buy/sell sentiment. Insider trading direction is shown in the insider section below.

Event Type Distribution

Count per 8-K item

Insider Transaction History

759 transaction records

Net Insider Flow

Monthly open-market buy value minus open-market sell value

Monthly Insider Activity Mix

Share volume split between open-market trades, grants, and exercises

Transaction Value Timeline

Each circle = one priced transaction; size ∝ value X-axis date:

All Transactions

Date	Insider	Title	Type	Security	Shares	Price	Total Value	Post-Tx Shares
2026-04-01	Liu Joy	EVP and Chief Legal Officer	Open-market sell S	Common Stock	978	$449.17	$439,288	21,833
2026-03-27	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	2,329	$450.95	$1,050,263	33,076
2026-03-13	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	2,329	$481.79	$1,122,089	35,405
2026-03-11	McKechnie Duncan	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,633	$498.42	$1,312,340	12,489
2026-03-04	McKechnie Duncan	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,437	$475.30	$1,158,306	15,122
2026-03-02	Liu Joy	EVP and Chief Legal Officer	Open-market sell S	Common Stock	892	$495.96	$442,396	22,811
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	1,725	$496.95	$857,239	98,278
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	5,995	$496.16	$2,974,479	100,003
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	15,580	$495.38	$7,718,020	105,998
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	3,498	$494.33	$1,729,166	121,578
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	2,520	$493.29	$1,243,091	125,076
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	949	$491.30	$466,244	127,596
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	2,725	$490.54	$1,336,722	128,545
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	460	$489.32	$225,087	131,270
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	3,278	$488.27	$1,600,549	131,730
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	2,510	$487.13	$1,222,696	135,008
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	240	$482.84	$115,882	137,518
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	120	$481.50	$57,780	137,758
2026-02-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	400	$479.75	$191,900	137,878
2026-02-26	Ambrose Kristen	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	357	$483.36	$172,560	6,624
2026-02-24	WAGNER CHARLES F JR	EVP, CO & FO	Other disposed transaction F	Common Stock	1,744	$485.11	$846,032	47,042
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Exercise / conversion M · derivative	Stock Option (Right to Buy)	25,026	$0.00	$0	0
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Exercise / conversion M · derivative	Stock Option (Right to Buy)	23,479	$0.00	$0	0
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Open-market sell S	Common Stock	4,237	$471.43	$1,997,449	58,934
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Open-market sell S	Common Stock	11,712	$470.54	$5,510,964	63,171
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Open-market sell S	Common Stock	7,241	$469.61	$3,400,446	74,883
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Open-market sell S	Common Stock	19,662	$468.57	$9,213,023	82,124
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Open-market sell S	Common Stock	10,263	$467.75	$4,800,518	101,786
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Open-market sell S	Common Stock	1,848	$465.80	$860,798	112,049
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Open-market sell S	Common Stock	2,730	$465.05	$1,269,586	113,897
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Open-market sell S	Common Stock	920	$463.91	$426,797	116,627
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Exercise / conversion M	Common Stock	25,026	$187.53	$4,693,126	117,547
2026-02-19	Sachdev Amit	EVP Chief Patient & Ext Af Off	Exercise / conversion M	Common Stock	23,479	$155.57	$3,652,628	92,521
2026-02-17	WAGNER CHARLES F JR	EVP, CO & FO	Other disposed transaction F	Common Stock	2,294	$483.75	$1,109,722	48,786
2026-02-17	WAGNER CHARLES F JR	EVP, CO & FO	Equity grant / award A	Common Stock	7,365	$0.00	$0	51,080
2026-02-13	WAGNER CHARLES F JR	EVP, CO & FO	Other disposed transaction F	Common Stock	4,565	$487.76	$2,226,624	43,715
2026-02-10	WAGNER CHARLES F JR	EVP, CO & FO	Other disposed transaction F	Common Stock	3,045	$468.41	$1,426,308	48,280
2026-01-22	WAGNER CHARLES F JR	EVP, CO & FO	Equity grant / award A	Common Stock	4,160	$0.00	$0	51,325
2026-01-22	WAGNER CHARLES F JR	EVP, CO & FO	Equity grant / award A	Common Stock	9,440	$0.00	$0	47,165
2026-01-15	Upadhyay Suketu	Dir	Equity grant / award A · derivative	Deferred Stock Units	80	$443.56	$35,625	2,719
2026-01-07	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	4,500	$474.99	$2,137,455	42,293
2026-01-06	WAGNER CHARLES F JR	EVP, CO & FO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	9,532	$0.00	$0	0
2026-01-06	WAGNER CHARLES F JR	EVP, CO & FO	Open-market sell S	Common Stock	9,532	$461.00	$4,394,252	37,725
2026-01-06	WAGNER CHARLES F JR	EVP, CO & FO	Exercise / conversion M	Common Stock	9,532	$189.38	$1,805,170	47,257
2025-12-03	WAGNER CHARLES F JR	EVP, CO & FO	Open-market sell S	Common Stock	7,000	$461.00	$3,227,000	37,725
2025-11-19	CARNEY LLOYD	Dir	Equity grant / award G	Common Stock	800	$0.00	$0	6,315
2025-11-17	Atkinson Edward Morrow III	EVP, Chief Technical Ops. Off.	Open-market sell S	Common Stock	2,500	$434.58	$1,086,450	16,852
2025-11-14	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	39,769	$0.00	$0	63,781
2025-11-14	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	13,835	$0.00	$0	1
2025-11-14	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	40	$442.00	$17,680	24,026
2025-11-14	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	21,330	$441.35	$9,413,996	24,066
2025-11-14	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	32,234	$440.30	$14,192,630	45,396
2025-11-14	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	39,769	$86.52	$3,440,814	77,630
2025-11-14	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	13,835	$91.05	$1,259,677	37,861
2025-11-13	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	19,688	$0.00	$0	13,836
2025-11-13	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	1,160	$441.05	$511,618	24,026
2025-11-13	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	18,528	$440.22	$8,156,396	25,186
2025-11-13	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	19,688	$91.05	$1,792,592	43,714
2025-10-15	Upadhyay Suketu	Dir	Equity grant / award A · derivative	Deferred Stock Units	87	$410.31	$35,625	2,638
2025-10-02	Biller Jonathan	EVP and Chief Legal Officer	Open-market sell S	Common Stock	694	$404.21	$280,522	15,653
2025-10-01	Biller Jonathan	EVP and Chief Legal Officer	Other disposed transaction F	Common Stock	1,259	$400.00	$503,600	16,347
2025-08-27	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	266	$386.69	$102,860	4,565
2025-08-06	Kewalramani Reshma	CEO & President	Open-market buy P	Common Stock	5,710	$389.95	$2,226,614	115,968
2025-08-06	Kewalramani Reshma	CEO & President	Open-market buy P	Common Stock	4,290	$389.08	$1,669,153	110,258
2025-07-15	Upadhyay Suketu	Dir	Equity grant / award A · derivative	Deferred Stock Units	76	$469.34	$35,625	2,552
2025-07-01	Arbuckle Stuart A	EVP, COO	Other disposed transaction F	Common Stock	37,243	$450.23	$16,767,916	63,368
2025-05-15	ALTSHULER DAVID	EVP, Chief Scientific Officer	Open-market sell S	Common Stock	52	$424.69	$22,084	23,281
2025-05-13	Arbuckle Stuart A	EVP, COO	Equity grant / award A	Common Stock	37,622	$0.00	$0	100,611
2025-05-01	Upadhyay Suketu	Dir	Equity grant / award A · derivative	Deferred Stock Units	1,001	—	—	2,476
2025-05-01	Upadhyay Suketu	Dir	Other disposed transaction D	Common Stock	1,001	—	—	2,354
2025-05-01	Upadhyay Suketu	Dir	Equity grant / award A	Common Stock	796	$0.00	$0	3,355
2025-04-15	Upadhyay Suketu	Dir	Equity grant / award A · derivative	Deferred Stock Units	72	$497.51	$35,625	1,475
2025-03-13	ALTSHULER DAVID	EVP, Chief Scientific Officer	Open-market sell S	Common Stock	3,231	$510.00	$1,647,810	23,281
2025-03-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	3,298	$500.00	$1,649,000	51,671
2025-03-04	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	4,058	$485.49	$1,970,118	54,481
2025-03-03	ALTSHULER DAVID	EVP, Chief Scientific Officer	Open-market sell S	Common Stock	3,231	$490.00	$1,583,190	29,743
2025-02-26	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	4,962	$479.61	$2,379,825	54,969
2025-02-24	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	3,310	$483.28	$1,599,657	59,931
2025-02-20	ALTSHULER DAVID	EVP, Chief Scientific Officer	Open-market sell S	Common Stock	1,111	$480.00	$533,280	45,019
2025-02-14	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	2,293	$463.46	$1,062,714	63,241
2025-02-12	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	6,655	$0.00	$0	65,534
2025-02-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	2,649	$467.98	$1,239,679	58,879
2025-02-04	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	7,114	$0.00	$0	61,528
2025-02-04	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	10,262	$0.00	$0	54,414
2025-01-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	112	$420.31	$46,929	15,145
2024-11-15	ALTSHULER DAVID	EVP, Chief Scientific Officer	Open-market sell S	Common Stock	15	$478.56	$7,178	25,813
2024-11-11	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	3,000	$518.27	$1,554,810	44,137
2024-11-08	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	15,198	$515.00	$7,826,970	75,772
2024-10-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	90	$484.39	$43,750	15,033
2024-10-02	Biller Jonathan	EVP and Chief Legal Officer	Open-market sell S	Common Stock	999	$461.66	$461,198	16,651
2024-10-01	Biller Jonathan	EVP and Chief Legal Officer	Other disposed transaction F	Common Stock	630	$466.84	$294,109	17,650
2024-08-30	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	3,784	$499.00	$1,888,216	9,994
2024-08-08	Bhatia Sangeeta N.	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,292	$0.00	$0	646
2024-08-08	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	1,292	$466.29	$602,447	4,435
2024-08-08	Bhatia Sangeeta N.	Dir	Exercise / conversion M	Common Stock	1,292	$152.74	$197,340	5,727
2024-08-07	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	2,280	$476.75	$1,086,990	23,259
2024-08-01	SACHS BRUCE I	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,295	$0.00	$0	0
2024-08-01	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	5,295	$508.00	$2,689,860	40,000
2024-08-01	SACHS BRUCE I	Dir	Exercise / conversion M	Common Stock	5,295	$125.71	$665,634	45,295
2024-07-30	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	15,202	$505.00	$7,677,010	90,970
2024-07-24	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	2,280	$488.46	$1,113,689	25,539
2024-07-22	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	15,202	$497.00	$7,555,394	106,172
2024-07-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	89	$490.12	$43,750	14,943
2024-07-10	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	2,280	$487.34	$1,111,135	27,819
2024-06-26	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	2,280	$471.72	$1,075,522	30,099
2024-06-12	Atkinson Edward Morrow III	EVP, Chief Technical Ops. Off.	Open-market sell S	Common Stock	7,288	$478.00	$3,483,664	15,972
2024-06-12	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	2,280	$478.00	$1,089,840	32,379
2024-06-11	Atkinson Edward Morrow III	EVP, Chief Technical Ops. Off.	Other disposed transaction F	Common Stock	6,824	$481.96	$3,288,895	23,260
2024-06-05	Sachdev Amit	EVP Chief Patient & Ext Af Off	Equity grant / award G	Common Stock	4,600	$0.00	$0	0
2024-06-03	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	3,250	$460.00	$1,495,000	47,137
2024-05-31	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	2,250	$445.00	$1,001,250	51,273
2024-05-30	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	2,350	$439.11	$1,031,908	53,523
2024-05-29	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	2,280	$445.56	$1,015,877	34,659
2024-05-28	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	3,250	$454.79	$1,478,068	50,387
2024-05-24	Kewalramani Reshma	CEO & President	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,565	$0.00	$0	0
2024-05-24	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	1,565	$457.00	$715,205	121,374
2024-05-24	Kewalramani Reshma	CEO & President	Exercise / conversion M	Common Stock	1,565	$187.53	$293,484	122,939
2024-05-22	SACHS BRUCE I	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,073	$0.00	$0	0
2024-05-22	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	7,073	$448.00	$3,168,704	40,000
2024-05-22	SACHS BRUCE I	Dir	Exercise / conversion M	Common Stock	7,073	$93.51	$661,396	47,073
2024-05-20	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	15,202	$447.00	$6,795,294	121,374
2024-05-15	Sachdev Amit	EVP Chief Patient & Ext Af Off	Open-market sell S	Common Stock	32	$430.93	$13,790	55,325
2024-05-14	Atkinson Edward Morrow III	EVP, Chief Technical Ops. Off.	Equity grant / award A	Common Stock	14,112	$0.00	$0	30,084
2024-05-01	Upadhyay Suketu	Dir	Equity grant / award A · derivative	Deferred Stock Units	1,168	—	—	1,403
2024-05-01	Upadhyay Suketu	Dir	Other disposed transaction D	Common Stock	1,168	—	—	2,559
2024-05-01	Upadhyay Suketu	Dir	Equity grant / award A	Common Stock	1,001	$0.00	$0	3,727
2024-04-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	109	$399.58	$43,750	14,854
2024-04-02	Ambrose Kristen	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	240	$419.00	$100,560	7,500
2024-04-01	Ambrose Kristen	SVP & Chief Accounting Officer	Other disposed transaction F	Common Stock	225	$418.10	$94,072	7,740
2024-02-23	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	3,309	$431.79	$1,428,793	53,583
2024-02-21	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	360	$421.77	$151,837	59,467
2024-02-20	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	2,812	$420.58	$1,182,671	56,892
2024-02-20	LEIDEN JEFFREY M	Executive Chairman	Other disposed transaction F	Common Stock	4,118	$420.58	$1,731,948	13,778
2024-02-16	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	3,750	$424.01	$1,590,038	59,704
2024-02-15	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	4,655	$419.16	$1,951,190	17,896
2024-02-14	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	4,356	$419.04	$1,825,338	22,551
2024-02-13	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	737	$419.13	$308,899	26,907
2024-02-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	647	$420.39	$271,992	27,644
2024-02-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	2,009	$419.22	$842,213	28,291
2024-02-09	LEIDEN JEFFREY M	Executive Chairman	Other disposed transaction F	Common Stock	8,048	$422.74	$3,402,212	30,300
2024-02-09	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	2,607	$422.74	$1,102,083	63,454
2024-02-08	LEIDEN JEFFREY M	Executive Chairman	Other disposed transaction F	Common Stock	2,698	$421.73	$1,137,828	38,348
2024-02-07	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	7,114	$0.00	$0	66,061
2024-02-06	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	9,440	$0.00	$0	58,947
2024-02-06	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	5,814	$0.00	$0	49,507
2024-01-12	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	101	$432.99	$43,750	14,744
2024-01-08	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	6,648	$419.07	$2,785,977	2,423
2024-01-02	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	3,000	$405.00	$1,215,000	43,693
2023-12-15	Kewalramani Reshma	CEO & President	Exercise / conversion M · derivative	Stock Option (Right to Buy)	14,077	$0.00	$0	1,565
2023-12-15	Kewalramani Reshma	CEO & President	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,058	$0.00	$0	0
2023-12-15	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	17,135	$407.00	$6,973,945	108,711
2023-12-15	Kewalramani Reshma	CEO & President	Exercise / conversion M	Common Stock	14,077	$187.53	$2,639,860	125,846
2023-12-15	Kewalramani Reshma	CEO & President	Exercise / conversion M	Common Stock	3,058	$155.57	$475,733	111,769
2023-12-13	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	100	$400.19	$40,019	9,071
2023-12-13	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	13,254	$399.41	$5,293,780	9,171
2023-12-05	Thornberry Nancy	Dir	Equity grant / award A	Common Stock	1,136	$0.00	$0	1,136
2023-11-20	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	3,000	$349.88	$1,049,640	46,693
2023-11-15	Sachdev Amit	EVP Chief Patient & Ext Af Off	Open-market sell S	Common Stock	35	$369.92	$12,947	58,814
2023-11-14	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	5,650	$380.82	$2,151,633	29,302
2023-11-13	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	5,097	$377.00	$1,921,569	113,809
2023-11-06	SACHS BRUCE I	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	11,250	$0.00	$0	11,250
2023-11-06	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	11,250	$385.00	$4,331,250	40,000
2023-11-06	SACHS BRUCE I	Dir	Exercise / conversion M	Common Stock	11,250	$127.54	$1,434,825	51,250
2023-10-31	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	5,651	$355.92	$2,011,304	34,952
2023-10-17	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	5,651	$373.25	$2,109,236	40,603
2023-10-16	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	12,962	$374.00	$4,847,788	22,425
2023-10-13	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	118	$369.98	$43,750	14,643
2023-10-06	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	242	$360.00	$87,120	4,144
2023-10-05	Lagarde Michel	Dir	Equity grant / award A	Common Stock	1,132	$0.00	$0	1,132
2023-10-03	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	5,651	$345.28	$1,951,177	46,254
2023-10-02	Biller Jonathan	EVP and Chief Legal Officer	Open-market sell S	Common Stock	610	$346.76	$211,524	10,569
2023-09-29	Biller Jonathan	EVP and Chief Legal Officer	Other disposed transaction F	Common Stock	408	$350.72	$143,094	11,179
2023-09-19	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	5,651	$351.00	$1,983,501	51,905
2023-09-05	Bozic Carmen	EVP and CMO	Open-market sell S	Common Stock	5,651	$352.66	$1,992,882	57,556
2023-08-23	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	2,500	$355.00	$887,500	48,637
2023-08-10	Kearney Terrence C	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	10,000	$0.00	$0	10,000
2023-08-10	Kearney Terrence C	Dir	Open-market sell S	Common Stock	10,000	$350.00	$3,500,000	6,536
2023-08-10	Kearney Terrence C	Dir	Exercise / conversion M	Common Stock	10,000	$127.54	$1,275,400	16,536
2023-08-09	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	63	$345.51	$21,767	32,038
2023-07-17	SACHS BRUCE I	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	11,250	$0.00	$0	11,250
2023-07-17	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	3,842	$357.29	$1,372,708	40,000
2023-07-17	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	5,711	$356.75	$2,037,399	43,842
2023-07-17	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	1,697	$355.54	$603,351	49,553
2023-07-17	SACHS BRUCE I	Dir	Exercise / conversion M	Common Stock	11,250	$127.54	$1,434,825	51,250
2023-07-17	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	7,828	$355.00	$2,778,940	118,906
2023-07-14	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	125	$350.79	$43,750	14,525
2023-06-15	Arbuckle Stuart A	EVP, COO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,603	$0.00	$0	8,603
2023-06-15	Arbuckle Stuart A	EVP, COO	Open-market sell S	Common Stock	8,603	$349.00	$3,002,447	56,556
2023-06-15	Arbuckle Stuart A	EVP, COO	Exercise / conversion M	Common Stock	8,603	$187.53	$1,613,321	65,159
2023-05-30	Arbuckle Stuart A	EVP, COO	Open-market sell S	Common Stock	82	$329.82	$27,045	56,556
2023-05-08	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	2,850	$350.00	$997,500	32,038
2023-05-05	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	422	$350.03	$147,713	34,888
2023-05-03	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	728	$351.60	$255,965	35,310
2023-05-03	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	2,053	$350.44	$719,453	36,038
2023-05-02	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	169	$353.24	$59,698	38,091
2023-05-02	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	42	$351.65	$14,769	38,260
2023-05-02	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	1,411	$350.32	$494,302	38,302
2023-05-01	Upadhyay Suketu	Dir	Equity grant / award A	Common Stock	1,168	$0.00	$0	2,726
2023-04-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	38	$340.19	$12,927	126,652
2023-04-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	1,668	$339.43	$566,169	126,690
2023-04-27	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	1,611	$338.69	$545,630	128,358
2023-04-14	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	131	$332.77	$43,750	14,400
2023-04-12	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	2,625	$327.43	$859,504	39,713
2023-04-12	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	4,068	$326.45	$1,327,999	42,338
2023-04-12	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	874	$325.70	$284,662	46,406
2023-04-04	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	31	$318.68	$9,879	47,280
2023-04-04	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	96	$317.65	$30,494	47,311
2023-04-04	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	90	$316.76	$28,508	47,407
2023-04-04	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	94	$315.66	$29,672	47,497
2023-04-04	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	211	$314.22	$66,300	47,591
2023-03-31	Sanna Bastiano	EVP, Cell & Genetic Therapies	Other disposed transaction F	Common Stock	1,466	$313.74	$459,943	47,802
2023-03-24	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	1,768	$305.38	$539,912	49,611
2023-03-17	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	16	$301.13	$4,818	51,379
2023-03-17	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	240	$299.58	$71,899	51,395
2023-03-17	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	784	$295.43	$231,617	52,235
2023-03-17	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	360	$298.09	$107,312	51,635
2023-03-16	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	264	$301.07	$79,482	49,268
2023-03-16	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	2,482	$300.54	$745,940	49,532
2023-03-13	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	62	$296.77	$18,400	53,379
2023-03-13	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	292	$295.89	$86,400	53,441
2023-03-13	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	715	$294.52	$210,582	53,733
2023-03-13	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	1,153	$293.35	$338,233	54,448
2023-03-13	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	420	$292.41	$122,812	55,061
2023-03-13	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	24	$288.31	$6,919	56,021
2023-03-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	102	$294.94	$30,084	56,045
2023-03-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	27	$293.61	$7,927	56,147
2023-03-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	185	$292.68	$54,146	56,174
2023-03-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	541	$291.47	$157,685	56,359
2023-03-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	30	$289.44	$8,683	56,900
2023-03-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	327	$288.91	$94,474	56,930
2023-03-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	515	$287.83	$148,232	57,257
2023-03-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	361	$286.64	$103,477	57,772
2023-02-24	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	3,308	$289.12	$956,409	58,133
2023-02-22	Arbuckle Stuart A	EVP, COO	Open-market sell S	Common Stock	200	$296.31	$59,262	66,304
2023-02-22	Arbuckle Stuart A	EVP, COO	Open-market sell S	Common Stock	394	$295.38	$116,380	66,504
2023-02-22	Arbuckle Stuart A	EVP, COO	Open-market sell S	Common Stock	1,378	$294.29	$405,532	66,898
2023-02-22	Arbuckle Stuart A	EVP, COO	Open-market sell S	Common Stock	300	$292.86	$87,858	68,276
2023-02-22	Arbuckle Stuart A	EVP, COO	Open-market sell S	Common Stock	129	$291.84	$37,647	68,576
2023-02-17	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	3,750	$292.85	$1,098,188	61,441
2023-02-14	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	51	$300.58	$15,330	65,445
2023-02-14	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	135	$299.60	$40,446	65,496
2023-02-14	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	43	$297.98	$12,813	65,631
2023-02-14	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	20	$296.48	$5,930	65,674
2023-02-14	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	71	$295.89	$21,008	65,694
2023-02-13	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	4,992	$298.26	$1,488,914	65,191
2023-02-13	LEIDEN JEFFREY M	Executive Chairman	Other disposed transaction F	Common Stock	13,344	$298.26	$3,979,981	62,079
2023-02-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	2,707	$294.33	$796,751	70,183
2023-02-06	ALTSHULER DAVID	EVP, Global Research and CSO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,304	$0.00	$0	0
2023-02-06	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	153	$309.06	$47,286	68,645
2023-02-06	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	620	$306.70	$190,154	68,798
2023-02-06	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	349	$305.08	$106,473	69,418
2023-02-06	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	100	$303.64	$30,364	69,767
2023-02-06	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	70	$302.00	$21,140	69,867
2023-02-06	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	12	$300.39	$3,605	69,937
2023-02-06	ALTSHULER DAVID	EVP, Global Research and CSO	Exercise / conversion M	Common Stock	1,304	$187.53	$244,539	69,949
2023-02-01	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	9,440	$0.00	$0	72,890
2023-02-01	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	10,262	$0.00	$0	63,450
2023-02-01	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	10,324	$0.00	$0	53,188
2023-01-31	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	106	$325.00	$34,450	37,998
2023-01-30	CARNEY LLOYD	Dir	Open-market sell S	Common Stock	324	$321.84	$104,276	4,150
2023-01-30	CARNEY LLOYD	Dir	Open-market sell S	Common Stock	1,000	$320.70	$320,700	4,474
2023-01-30	CARNEY LLOYD	Dir	Open-market sell S	Common Stock	1,376	$320.08	$440,430	5,474
2023-01-27	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,429	$0.00	$0	0
2023-01-27	Lee Yuchun	Dir	Open-market sell S	Common Stock	80	$323.33	$25,866	1,875
2023-01-27	Lee Yuchun	Dir	Open-market sell S	Common Stock	970	$322.20	$312,534	1,955
2023-01-27	Lee Yuchun	Dir	Open-market sell S	Common Stock	379	$321.31	$121,776	2,925
2023-01-27	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	1,429	$72.14	$103,088	3,304
2023-01-26	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,000	$0.00	$0	1,429
2023-01-26	Lee Yuchun	Dir	Open-market sell S	Common Stock	680	$320.94	$218,239	1,875
2023-01-26	Lee Yuchun	Dir	Open-market sell S	Common Stock	400	$320.25	$128,100	2,555
2023-01-26	Lee Yuchun	Dir	Open-market sell S	Common Stock	478	$319.25	$152,602	2,955
2023-01-26	Lee Yuchun	Dir	Open-market sell S	Common Stock	1,000	$317.95	$317,950	3,433
2023-01-26	Lee Yuchun	Dir	Open-market sell S	Common Stock	1,140	$316.82	$361,175	4,433
2023-01-26	Lee Yuchun	Dir	Open-market sell S	Common Stock	302	$315.42	$95,257	5,573
2023-01-26	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	4,000	$72.14	$288,560	5,875
2023-01-25	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,000	$0.00	$0	5,429
2023-01-25	Lee Yuchun	Dir	Open-market sell S	Common Stock	579	$314.95	$182,356	1,875
2023-01-25	Lee Yuchun	Dir	Open-market sell S	Common Stock	2,621	$314.10	$823,256	2,454
2023-01-25	Lee Yuchun	Dir	Open-market sell S	Common Stock	800	$312.80	$250,240	5,075
2023-01-25	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	4,000	$72.14	$288,560	5,875
2023-01-24	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,000	$0.00	$0	9,429
2023-01-24	Lee Yuchun	Dir	Open-market sell S	Common Stock	1,489	$313.36	$466,593	1,875
2023-01-24	Lee Yuchun	Dir	Open-market sell S	Common Stock	2,511	$312.29	$784,160	3,364
2023-01-24	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	4,000	$72.14	$288,560	5,875
2023-01-23	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,129	$0.00	$0	13,429
2023-01-23	Lee Yuchun	Dir	Open-market sell S	Common Stock	2,129	$312.02	$664,291	1,875
2023-01-23	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,129	$72.14	$153,586	4,004
2023-01-18	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	442	$0.00	$0	15,558
2023-01-18	Lee Yuchun	Dir	Open-market sell S	Common Stock	442	$312.17	$137,979	1,875
2023-01-18	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	442	$72.14	$31,886	2,317
2023-01-17	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,000	$0.00	$0	16,000
2023-01-17	Lee Yuchun	Dir	Open-market sell S	Common Stock	4,000	$312.03	$1,248,120	1,875
2023-01-17	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	4,000	$72.14	$288,560	5,875
2023-01-13	Upadhyay Suketu	Dir	Equity grant / award A · derivative	Deferred Stock Units	96	$298.42	$28,750	235
2022-12-06	Arbuckle Stuart A	EVP, COO	Equity grant / award A	Common Stock	12,753	$0.00	$0	58,031
2022-11-15	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	34	$308.61	$10,493	36,077
2022-11-07	ALTSHULER DAVID	EVP, Global Research and CSO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,303	$0.00	$0	1,304
2022-11-07	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	83	$306.57	$25,445	36,077
2022-11-07	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	280	$304.58	$85,282	36,300
2022-11-07	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	261	$303.21	$79,138	36,580
2022-11-07	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	189	$301.99	$57,076	36,841
2022-11-07	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	210	$300.96	$63,202	37,030
2022-11-07	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	140	$305.39	$42,755	36,160
2022-11-07	ALTSHULER DAVID	EVP, Global Research and CSO	Exercise / conversion M	Common Stock	1,303	$187.53	$244,352	37,380
2022-11-02	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	22	$317.77	$6,991	38,104
2022-11-02	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	10	$315.68	$3,157	38,126
2022-11-02	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	12	$314.43	$3,773	38,136
2022-11-02	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	81	$313.37	$25,383	38,148
2022-11-02	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	100	$312.40	$31,240	38,229
2022-11-02	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	39	$311.17	$12,136	38,329
2022-11-02	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	56	$310.10	$17,366	38,368
2022-11-01	Sanna Bastiano	EVP, Cell & Genetic Therapies	Other disposed transaction F	Common Stock	768	$312.84	$240,261	38,424
2022-10-24	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	621	$310.00	$192,510	4,040
2022-10-18	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	288	$301.84	$86,930	39,192
2022-10-18	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	1,503	$300.02	$450,930	39,480
2022-10-14	Upadhyay Suketu	Dir	Equity grant / award A · derivative	Deferred Stock Units	97	$296.82	$28,750	139
2022-09-19	Biller Jonathan	EVP and Chief Legal Officer	Equity grant / award A	Common Stock	5,294	$0.00	$0	5,294
2022-08-15	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	11,689	$305.06	$3,565,846	99,598
2022-08-10	Arbuckle Stuart A	EVP, COO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	64	$0.00	$0	6,571
2022-08-10	Arbuckle Stuart A	EVP, COO	Open-market sell S	Common Stock	9	$302.01	$2,718	60,880
2022-08-10	Arbuckle Stuart A	EVP, COO	Open-market sell S	Common Stock	171	$300.32	$51,355	60,889
2022-08-10	Arbuckle Stuart A	EVP, COO	Exercise / conversion M	Common Stock	64	$155.57	$9,956	61,060
2022-08-09	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	946	$300.00	$283,800	13,388
2022-08-08	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	47	$295.53	$13,890	4,661
2022-08-08	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	161	$294.24	$47,373	4,708
2022-08-08	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	204	$293.15	$59,803	4,869
2022-08-08	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	164	$291.76	$47,849	5,073
2022-08-08	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	45	$290.18	$13,058	5,237
2022-08-01	Sanna Bastiano	EVP, Cell & Genetic Therapies	Other disposed transaction F	Common Stock	766	$276.62	$211,891	40,983
2022-07-29	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	5	$282.34	$1,412	5,282
2022-07-29	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	58	$281.03	$16,300	5,287
2022-07-29	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	160	$279.28	$44,685	5,444
2022-07-29	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	200	$277.95	$55,590	5,604
2022-07-29	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	99	$280.22	$27,742	5,345
2022-07-25	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	60,342	$0.00	$0	33,524
2022-07-25	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	10,471	$283.42	$2,967,691	2,423
2022-07-25	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	40,666	$282.43	$11,485,298	12,894
2022-07-25	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	34,090	$281.27	$9,588,494	53,560
2022-07-25	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	32,983	$280.37	$9,247,444	87,650
2022-07-25	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	13,869	$279.44	$3,875,553	120,633
2022-07-25	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	60,342	$91.05	$5,494,139	134,502
2022-07-19	ALTSHULER DAVID	EVP, Global Research and CSO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	7,338	$0.00	$0	0
2022-07-19	ALTSHULER DAVID	EVP, Global Research and CSO	Exercise / conversion M · derivative	Stock Option (Right to Buy)	10,427	$0.00	$0	3,911
2022-07-19	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	6,604	$289.48	$1,911,726	36,077
2022-07-19	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	5,737	$288.67	$1,656,100	42,681
2022-07-19	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	4,561	$287.83	$1,312,793	48,418
2022-07-19	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	963	$286.72	$276,111	52,979
2022-07-19	ALTSHULER DAVID	EVP, Global Research and CSO	Exercise / conversion M	Common Stock	7,338	$155.57	$1,141,573	53,942
2022-07-19	ALTSHULER DAVID	EVP, Global Research and CSO	Exercise / conversion M	Common Stock	10,427	$187.53	$1,955,375	46,604
2022-07-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	151	$289.23	$43,750	13,975
2022-06-24	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	11,689	$291.30	$3,405,006	111,153
2022-05-31	Bozic Carmen	EVP and CMO	Other disposed transaction F	Common Stock	311	$271.24	$84,356	49,512
2022-05-18	Upadhyay Suketu	Dir	Equity grant / award A	Common Stock	1,558	$0.00	$0	1,558
2022-05-16	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	15	$253.99	$3,810	41,757
2022-05-16	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	8	$254.44	$2,036	41,749
2022-05-16	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	7	$252.43	$1,767	41,772
2022-05-04	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	36	$275.09	$9,903	41,660
2022-05-02	Arbuckle Stuart A	EVP, COO	Open-market sell S	Common Stock	306	$263.98	$80,778	64,760
2022-05-01	Kearney Terrence C	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	2,231	$0.00	$0	2,231
2022-05-01	Kearney Terrence C	Dir	Equity grant / award A	Common Stock	725	$0.00	$0	6,536
2022-04-29	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	10	$278.04	$2,780	14,334
2022-04-29	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	22	$276.72	$6,088	14,344
2022-04-29	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	30	$275.62	$8,269	14,366
2022-04-29	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	41	$274.75	$11,265	14,396
2022-04-29	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	17	$273.37	$4,647	14,437
2022-04-25	Ambrose Kristen	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	104	$271.68	$28,255	3,496
2022-04-25	Ambrose Kristen	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	83	$269.51	$22,369	3,600
2022-04-25	Ambrose Kristen	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	80	$268.46	$21,477	3,683
2022-04-25	Ambrose Kristen	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	60	$267.37	$16,042	3,763
2022-04-18	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	0
2022-04-18	Lee Yuchun	Dir	Open-market sell S	Common Stock	119	$286.80	$34,129	1,875
2022-04-18	Lee Yuchun	Dir	Open-market sell S	Common Stock	491	$285.16	$140,014	1,994
2022-04-18	Lee Yuchun	Dir	Open-market sell S	Common Stock	1,008	$284.06	$286,332	2,485
2022-04-18	Lee Yuchun	Dir	Open-market sell S	Common Stock	382	$282.70	$107,991	3,493
2022-04-18	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$81.54	$163,080	3,875
2022-04-14	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	2,000
2022-04-14	Lee Yuchun	Dir	Open-market sell S	Common Stock	400	$291.18	$116,472	1,875
2022-04-14	Lee Yuchun	Dir	Open-market sell S	Common Stock	252	$288.92	$72,808	2,675
2022-04-14	Lee Yuchun	Dir	Open-market sell S	Common Stock	948	$287.87	$272,901	2,927
2022-04-14	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$81.54	$163,080	3,875
2022-04-13	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	4,000
2022-04-13	Lee Yuchun	Dir	Open-market sell S	Common Stock	354	$291.12	$103,056	1,875
2022-04-13	Lee Yuchun	Dir	Open-market sell S	Common Stock	400	$288.55	$115,420	2,429
2022-04-13	Lee Yuchun	Dir	Open-market sell S	Common Stock	200	$290.17	$58,034	2,229
2022-04-13	Lee Yuchun	Dir	Open-market sell S	Common Stock	228	$284.90	$64,957	3,329
2022-04-13	Lee Yuchun	Dir	Open-market sell S	Common Stock	300	$286.24	$85,872	3,029
2022-04-13	Lee Yuchun	Dir	Open-market sell S	Common Stock	18	$281.49	$5,067	3,857
2022-04-13	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$81.54	$163,080	3,875
2022-04-13	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	15,789	$289.04	$4,563,653	74,160
2022-04-12	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	6,000
2022-04-12	Lee Yuchun	Dir	Open-market sell S	Common Stock	300	$283.15	$84,945	1,875
2022-04-12	Lee Yuchun	Dir	Open-market sell S	Common Stock	318	$281.70	$89,581	2,175
2022-04-12	Lee Yuchun	Dir	Open-market sell S	Common Stock	1,182	$280.61	$331,681	2,493
2022-04-12	Lee Yuchun	Dir	Open-market sell S	Common Stock	200	$279.22	$55,844	3,675
2022-04-12	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$81.54	$163,080	3,875
2022-04-11	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	8,000
2022-04-11	Lee Yuchun	Dir	Open-market sell S	Common Stock	110	$281.58	$30,974	1,875
2022-04-11	Lee Yuchun	Dir	Open-market sell S	Common Stock	968	$280.62	$271,640	1,985
2022-04-11	Lee Yuchun	Dir	Open-market sell S	Common Stock	922	$279.81	$257,985	2,953
2022-04-11	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$81.54	$163,080	3,875
2022-04-08	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	10,000
2022-04-08	Lee Yuchun	Dir	Open-market sell S	Common Stock	452	$280.37	$126,727	1,875
2022-04-08	Lee Yuchun	Dir	Open-market sell S	Common Stock	700	$279.36	$195,552	2,327
2022-04-08	Lee Yuchun	Dir	Open-market sell S	Common Stock	430	$277.29	$119,235	3,027
2022-04-08	Lee Yuchun	Dir	Open-market sell S	Common Stock	418	$276.62	$115,627	3,457
2022-04-08	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$81.54	$163,080	3,875
2022-04-07	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	12,000
2022-04-07	Lee Yuchun	Dir	Open-market sell S	Common Stock	100	$277.02	$27,702	1,875
2022-04-07	Lee Yuchun	Dir	Open-market sell S	Common Stock	727	$276.37	$200,921	1,975
2022-04-07	Lee Yuchun	Dir	Open-market sell S	Common Stock	256	$275.26	$70,467	2,702
2022-04-07	Lee Yuchun	Dir	Open-market sell S	Common Stock	500	$273.78	$136,890	2,958
2022-04-07	Lee Yuchun	Dir	Open-market sell S	Common Stock	417	$272.76	$113,741	3,458
2022-04-07	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$81.54	$163,080	3,875
2022-04-07	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	30	$277.02	$8,311	42,782
2022-04-07	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	327	$276.39	$90,380	42,812
2022-04-07	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	204	$275.71	$56,245	43,139
2022-04-06	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	14,000
2022-04-06	Lee Yuchun	Dir	Open-market sell S	Common Stock	83	$272.84	$22,646	1,875
2022-04-06	Lee Yuchun	Dir	Open-market sell S	Common Stock	1,600	$271.78	$434,848	1,958
2022-04-06	Lee Yuchun	Dir	Open-market sell S	Common Stock	300	$270.67	$81,201	3,558
2022-04-06	Lee Yuchun	Dir	Open-market sell S	Common Stock	17	$267.57	$4,549	3,858
2022-04-06	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$81.54	$163,080	3,875
2022-04-05	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	3,163	$275.23	$870,552	43,343
2022-04-04	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	257	$268.43	$68,987	46,506
2022-04-04	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	305	$267.10	$81,466	46,763
2022-04-01	Ambrose Kristen	SVP & Chief Accounting Officer	Other disposed transaction F	Common Stock	137	$263.09	$36,043	3,823
2022-03-31	MCGLYNN MARGARET G	Dir	Exercise / conversion M · derivative	Common Stock (right to buy)	5,000	$127.54	$637,700	10,000
2022-03-31	MCGLYNN MARGARET G	Dir	Open-market sell S	Common Stock	1,011	$262.97	$265,863	1,099
2022-03-31	MCGLYNN MARGARET G	Dir	Open-market sell S	Common Stock	2,970	$262.37	$779,239	2,110
2022-03-31	MCGLYNN MARGARET G	Dir	Open-market sell S	Common Stock	1,019	$261.28	$266,244	5,080
2022-03-31	MCGLYNN MARGARET G	Dir	Exercise / conversion M	Common Stock	5,000	$127.54	$637,700	6,099
2022-03-17	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	34	$251.24	$8,542	47,356
2022-03-17	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Open-market sell S	Common Stock	2,799	$250.10	$700,030	47,390
2022-02-24	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	2,189	$227.86	$498,786	49,373
2022-02-17	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	3,439	$232.51	$799,602	51,562
2022-02-14	ALTSHULER DAVID	EVP, Global Research and CSO	Open-market sell S	Common Stock	2,444	$232.02	$567,057	57,438
2022-02-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	2,434	$237.74	$578,659	55,001
2022-02-02	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	2,944	$250.07	$736,206	57,435
2022-02-01	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	10,262	$0.00	$0	60,379
2022-02-01	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	11,628	$0.00	$0	50,117
2022-02-01	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	3,698	$0.00	$0	38,489
2022-01-28	MCGLYNN MARGARET G	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	5,000	$127.54	$637,700	15,000
2022-01-28	MCGLYNN MARGARET G	Dir	Open-market sell S	Common Stock	212	$243.24	$51,567	1,099
2022-01-28	MCGLYNN MARGARET G	Dir	Open-market sell S	Common Stock	2,087	$242.78	$506,682	1,311
2022-01-28	MCGLYNN MARGARET G	Dir	Open-market sell S	Common Stock	800	$241.83	$193,464	3,398
2022-01-28	MCGLYNN MARGARET G	Dir	Open-market sell S	Common Stock	1,901	$240.53	$457,248	4,198
2022-01-28	MCGLYNN MARGARET G	Dir	Exercise / conversion M	Common Stock	5,000	$127.54	$637,700	6,099
2022-01-14	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	190	$230.58	$43,750	13,672
2021-11-15	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	30	$187.48	$5,624	31,928
2021-11-15	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	21	$186.78	$3,922	31,958
2021-11-01	Sanna Bastiano	EVP, Cell & Genetic Therapies	Other disposed transaction F	Common Stock	766	$185.07	$141,764	32,576
2021-10-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	240	$182.07	$43,750	13,483
2021-08-19	Kewalramani Reshma	CEO & President	Open-market buy P	Common Stock	4,243	$196.34	$833,071	73,754
2021-08-19	Kewalramani Reshma	CEO & President	Open-market buy P	Common Stock	5,757	$195.14	$1,123,421	69,511
2021-08-02	SACHS BRUCE I	Dir	Open-market buy P	Common Stock	15,000	$197.91	$2,968,650	41,210
2021-07-30	Sanna Bastiano	EVP, Cell & Genetic Therapies	Other disposed transaction F	Common Stock	766	$200.39	$153,499	33,342
2021-07-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	221	$198.00	$43,750	13,242
2021-06-02	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	121	$211.00	$25,531	5,191
2021-06-02	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	153	$210.01	$32,132	5,312
2021-06-02	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	285	$208.96	$59,554	5,465
2021-06-01	MCGLYNN MARGARET G	Dir	Equity grant / award A · derivative	Deferred Stock Units	699	—	—	4,688
2021-06-01	MCGLYNN MARGARET G	Dir	Other disposed transaction D	Common Stock	699	—	—	1,099
2021-05-28	Bozic Carmen	EVP and CMO	Other disposed transaction F	Common Stock	311	$210.04	$65,322	32,953
2021-05-17	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	47	$216.88	$10,193	34,108
2021-05-17	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	65	$215.95	$14,037	34,155
2021-05-01	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	6,067	$0.00	$0	6,067
2021-04-30	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	547	$217.21	$118,814	34,679
2021-04-27	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	3,884	$0.00	$0	0
2021-04-27	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	200	$217.69	$43,538	40,133
2021-04-27	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	1,338	$216.67	$289,904	40,333
2021-04-27	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	2,346	$215.58	$505,751	41,671
2021-04-27	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M	Common Stock	3,884	$86.52	$336,044	44,017
2021-04-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	199	$220.17	$43,750	13,021
2021-04-05	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	389	$214.99	$83,631	35,834
2021-04-05	Sanna Bastiano	EVP, Cell & Genetic Therapies	Open-market sell S	Common Stock	1,297	$213.89	$277,415	36,223
2021-04-01	Sanna Bastiano	EVP, Cell & Genetic Therapies	Other disposed transaction F	Common Stock	1,344	$214.16	$287,831	37,520
2021-03-05	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	256	$212.28	$54,344	8,253
2021-03-05	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	1,460	$211.67	$309,038	8,509
2021-03-05	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	844	$210.64	$177,780	9,969
2021-03-05	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	111	$209.37	$23,240	10,813
2021-03-05	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	1,119	$208.39	$233,188	10,924
2021-03-05	Liu Joy	SVP, General Counsel	Open-market sell S	Common Stock	1,351	$207.57	$280,427	12,043
2021-03-01	Silva Paul M	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	231	$213.12	$49,231	9,884
2021-03-01	Silva Paul M	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	915	$212.51	$194,447	10,115
2021-03-01	Silva Paul M	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	610	$211.45	$128,984	11,030
2021-03-01	Silva Paul M	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	1,026	$210.13	$215,593	11,640
2021-02-26	Silva Paul M	SVP & Chief Accounting Officer	Other disposed transaction F	Common Stock	2,218	$212.42	$471,148	12,666
2021-02-24	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	547	$217.57	$119,011	35,226
2021-02-17	Tatsis Ourania	EVP, Chief Reg. & Quality Off.	Other disposed transaction F	Common Stock	2,000	$211.75	$423,500	32,468
2021-02-11	Silva Paul M	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	210	$211.32	$44,377	23,863
2021-02-11	Silva Paul M	SVP & Chief Accounting Officer	Open-market sell S	Common Stock	1,288	$210.45	$271,060	24,073
2021-02-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Other disposed transaction F	Common Stock	2,365	$214.16	$506,488	35,773
2021-02-05	Parini Michael	EVP, Chief Adm, Leg & BD Off	Open-market sell S	Common Stock	1,930	$215.00	$414,950	57,227
2021-02-05	Parini Michael	EVP, Chief Adm, Leg & BD Off	Exercise / conversion M · derivative	Common Stock	1,930	$0.00	$0	0
2021-02-03	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	11,627	$0.00	$0	38,138
2021-02-03	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Equity grant / award A	Common Stock	10,324	$0.00	$0	26,511
2021-01-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	194	$225.99	$43,750	12,823
2020-11-16	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	8	$224.44	$1,796	35,103
2020-11-16	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	22	$223.76	$4,923	35,111
2020-11-16	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	12	$222.50	$2,670	35,133
2020-11-10	SACHS BRUCE I	Dir	Open-market buy P	Common Stock	3,905	$218.79	$854,375	26,210
2020-11-10	SACHS BRUCE I	Dir	Open-market buy P	Common Stock	4,270	$217.49	$928,682	22,305
2020-11-10	SACHS BRUCE I	Dir	Open-market buy P	Common Stock	6,825	$216.47	$1,477,408	18,035
2020-11-04	Parini Michael	EVP, Chief Adm, Leg & BD Off	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,330	$0.00	$0	2,330
2020-11-04	Parini Michael	EVP, Chief Adm, Leg & BD Off	Open-market sell S	Common Stock	200	$221.25	$44,250	26,838
2020-11-04	Parini Michael	EVP, Chief Adm, Leg & BD Off	Open-market sell S	Common Stock	300	$220.10	$66,030	27,038
2020-11-04	Parini Michael	EVP, Chief Adm, Leg & BD Off	Open-market sell S	Common Stock	600	$218.63	$131,178	27,338
2020-11-04	Parini Michael	EVP, Chief Adm, Leg & BD Off	Open-market sell S	Common Stock	630	$215.16	$135,551	28,538
2020-11-04	Parini Michael	EVP, Chief Adm, Leg & BD Off	Exercise / conversion M	Common Stock	2,330	$86.52	$201,592	29,168
2020-11-03	Arbuckle Stuart A	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,553	$0.00	$0	1,554
2020-11-03	Arbuckle Stuart A	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	334	$214.13	$71,519	35,179
2020-11-03	Arbuckle Stuart A	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	245	$212.38	$52,033	35,513
2020-11-03	Arbuckle Stuart A	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	487	$211.54	$103,020	35,758
2020-11-03	Arbuckle Stuart A	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	1,553	$86.52	$134,366	36,732
2020-10-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	196	$222.81	$43,750	12,629
2020-10-05	Bhatia Sangeeta N.	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	8,729	$0.00	$0	0
2020-10-05	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	2,212	$268.61	$594,165	3,908
2020-10-05	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	2,670	$267.92	$715,346	6,120
2020-10-05	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	2,070	$266.66	$551,986	8,790
2020-10-05	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	1,787	$265.82	$475,020	10,860
2020-10-05	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	892	$264.60	$236,023	12,647
2020-10-05	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	594	$263.54	$156,543	13,539
2020-10-05	Bhatia Sangeeta N.	Dir	Open-market sell S	Common Stock	291	$262.66	$76,434	14,133
2020-10-05	Bhatia Sangeeta N.	Dir	Exercise / conversion M	Common Stock	8,729	$126.68	$1,105,790	14,424
2020-08-25	MCGLYNN MARGARET G	Dir	Equity grant / award G	Common Stock	3,707	$0.00	$0	877
2020-08-06	Silva Paul M	SVP & Controller	Exercise / conversion M · derivative	Stock Option (Right to Buy)	612	$0.00	$0	3,669
2020-08-06	Silva Paul M	SVP & Controller	Exercise / conversion M · derivative	Stock Option (Right to Buy)	466	$0.00	$0	4,656
2020-08-06	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	74	$272.87	$20,192	14,932
2020-08-06	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	373	$272.15	$101,512	15,006
2020-08-06	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	211	$270.92	$57,164	15,379
2020-08-06	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	420	$270.12	$113,450	15,590
2020-08-06	Silva Paul M	SVP & Controller	Exercise / conversion M	Common Stock	612	$155.57	$95,209	16,010
2020-08-06	Silva Paul M	SVP & Controller	Exercise / conversion M	Common Stock	466	$187.53	$87,389	15,398
2020-08-03	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,941	$0.00	$0	3,884
2020-08-03	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	751	$279.18	$209,664	35,103
2020-08-03	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	690	$278.25	$191,992	35,854
2020-08-03	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	500	$276.96	$138,480	36,544
2020-08-03	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M	Common Stock	1,941	$86.52	$167,935	37,044
2020-07-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	155	$292.77	$45,453	12,433
2020-07-13	Silva Paul M	SVP & Controller	Exercise / conversion M · derivative	Stock Options (Right to Buy)	860	$0.00	$0	0
2020-07-13	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	250	$294.99	$73,748	15,032
2020-07-13	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	200	$294.18	$58,836	15,282
2020-07-13	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	50	$291.97	$14,598	15,482
2020-07-13	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	60	$285.71	$17,143	15,632
2020-07-13	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	100	$295.78	$29,578	14,932
2020-07-13	Silva Paul M	SVP & Controller	Exercise / conversion M	Common Stock	860	$90.29	$77,649	15,792
2020-07-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	260	$293.90	$76,414	16,126
2020-07-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	400	$292.86	$117,144	16,386
2020-07-10	WAGNER CHARLES F JR	EVP & Chief Financial Officer	Open-market sell S	Common Stock	40	$291.19	$11,648	16,786
2020-07-07	Arbuckle Stuart A	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy)	1,222	$0.00	$0	8,561
2020-07-07	Arbuckle Stuart A	EVP, Chief Commercial Officer	Exercise / conversion M · derivative	Stock Option (Right to buy)	1,564	$0.00	$0	17,206
2020-07-07	Arbuckle Stuart A	EVP, Chief Commercial Officer	Open-market sell S	Common Stock	2,786	$300.00	$835,800	35,179
2020-07-07	Arbuckle Stuart A	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	1,222	$155.57	$190,107	37,965
2020-07-07	Arbuckle Stuart A	EVP, Chief Commercial Officer	Exercise / conversion M	Common Stock	1,564	$187.53	$293,297	36,743
2020-06-30	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	200	$291.34	$58,268	2,261
2020-06-30	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	2,534	$290.51	$736,152	2,461
2020-06-30	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	500	$289.39	$144,695	4,995
2020-06-30	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	1,318	$287.91	$379,465	5,495
2020-06-30	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	4,885	$287.23	$1,403,119	6,813
2020-06-30	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	8,321	$286.13	$2,380,888	11,698
2020-06-30	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	9,233	$285.11	$2,632,421	20,019
2020-06-30	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	5,801	$284.14	$1,648,296	29,252
2020-06-03	MCKENZIE DIANA	Dir	Equity grant / award A	Common Stock	1,435	$0.00	$0	1,435
2020-06-01	YOUNG WILLIAM D	Dir	Equity grant / award A · derivative	Stock Option (Right to Buy)	4,527	$0.00	$0	4,527
2020-05-29	Bozic Carmen	EVP and CMO	Other disposed transaction F	Common Stock	311	$282.74	$87,932	13,991
2020-05-15	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	19	$287.63	$5,465	26,635
2020-05-15	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	27	$286.07	$7,724	26,654
2020-05-15	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	10	$283.76	$2,838	26,681
2020-05-15	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	4	$282.74	$1,131	26,691
2020-05-15	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	9	$288.37	$2,595	26,626
2020-05-15	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	7	$279.70	$1,958	26,710
2020-05-15	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	6	$281.74	$1,690	26,695
2020-05-15	Kewalramani Reshma	CEO & President	Open-market sell S	Common Stock	2	$274.37	$549	26,723
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	24,348	$0.00	$0	0
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,470	$0.00	$0	93,866
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	35,499	$0.00	$0	0
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	24,215	$0.00	$0	0
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	100	$288.42	$28,842	34,983
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	9,630	$287.81	$2,771,610	35,083
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	15,792	$286.70	$4,527,566	44,713
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	8,391	$285.68	$2,397,141	60,505
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	10,179	$285.06	$2,901,626	68,896
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	9,219	$283.86	$2,616,905	79,075
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	9,780	$282.66	$2,764,415	88,294
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	9,398	$281.83	$2,648,638	98,074
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	6,498	$280.76	$1,824,378	107,472
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	1,940	$278.96	$541,182	113,970
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	4,428	$277.94	$1,230,718	115,910
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	9,015	$277.14	$2,498,417	120,338
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	24,348	$155.57	$3,787,818	129,353
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	4,470	$91.05	$406,994	105,005
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	35,499	$96.87	$3,438,788	100,535
2020-05-12	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	24,215	$187.53	$4,541,039	65,036
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	10,665	$0.00	$0	0
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	100	$286.72	$28,672	35,103
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	1,367	$285.94	$390,880	35,203
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	2,314	$285.15	$659,837	36,570
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	1,100	$283.98	$312,378	38,884
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	913	$282.89	$258,279	39,984
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	1,398	$281.74	$393,873	40,897
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	1,817	$280.77	$510,159	42,295
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	655	$279.67	$183,184	44,112
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	201	$277.38	$55,753	44,767
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	800	$276.25	$221,000	44,968
2020-05-11	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M	Common Stock	10,665	$131.89	$1,406,607	45,768
2020-05-07	SACHS BRUCE I	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	22,500	$0.00	$0	0
2020-05-07	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	2,960	$272.46	$806,482	11,210
2020-05-07	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	6,232	$271.63	$1,692,798	14,170
2020-05-07	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	5,889	$270.49	$1,592,916	20,402
2020-05-07	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	15,751	$269.53	$4,245,367	26,291
2020-05-07	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	11,568	$268.65	$3,107,743	42,042
2020-05-07	SACHS BRUCE I	Dir	Open-market sell S	Common Stock	2,600	$267.50	$695,500	53,610
2020-05-07	SACHS BRUCE I	Dir	Exercise / conversion M	Common Stock	22,500	$81.54	$1,834,650	56,210
2020-05-06	Tatsis Ourania	EVP, Chief Regulatory Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	407	$0.00	$0	2,854
2020-05-06	Tatsis Ourania	EVP, Chief Regulatory Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	559	$0.00	$0	6,145
2020-05-06	Tatsis Ourania	EVP, Chief Regulatory Officer	Open-market sell S	Common Stock	30	$275.30	$8,259	12,738
2020-05-06	Tatsis Ourania	EVP, Chief Regulatory Officer	Open-market sell S	Common Stock	330	$274.13	$90,463	12,768
2020-05-06	Tatsis Ourania	EVP, Chief Regulatory Officer	Open-market sell S	Common Stock	210	$273.15	$57,362	13,098
2020-05-06	Tatsis Ourania	EVP, Chief Regulatory Officer	Open-market sell S	Common Stock	217	$272.09	$59,044	13,308
2020-05-06	Tatsis Ourania	EVP, Chief Regulatory Officer	Open-market sell S	Common Stock	136	$270.19	$36,746	13,525
2020-05-06	Tatsis Ourania	EVP, Chief Regulatory Officer	Open-market sell S	Common Stock	43	$268.80	$11,558	13,661
2020-05-06	Tatsis Ourania	EVP, Chief Regulatory Officer	Exercise / conversion M	Common Stock	407	$155.57	$63,317	13,704
2020-05-06	Tatsis Ourania	EVP, Chief Regulatory Officer	Exercise / conversion M	Common Stock	559	$187.53	$104,829	13,297
2020-05-05	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	13,356	$0.00	$0	11,334
2020-05-05	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	200	$273.59	$54,718	35,103
2020-05-05	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	403	$272.58	$109,850	35,303
2020-05-05	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	11,553	$270.01	$3,119,426	35,806
2020-05-05	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	700	$269.08	$188,356	47,359
2020-05-05	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	300	$267.34	$80,202	48,059
2020-05-05	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	100	$271.09	$27,109	35,706
2020-05-05	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M	Common Stock	13,356	$131.89	$1,761,523	48,459
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	24,349	$0.00	$0	48,697
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,470	$0.00	$0	102,806
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	35,502	$0.00	$0	70,998
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M · derivative	Stock Option (Right to Buy)	24,216	$0.00	$0	48,431
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	5,375	$273.70	$1,471,138	46,656
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	12,849	$272.97	$3,507,392	52,031
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	11,832	$272.12	$3,219,724	64,880
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	6,003	$270.86	$1,625,973	76,712
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	15,681	$269.56	$4,226,970	82,715
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	22,613	$268.86	$6,079,731	98,396
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	10,878	$267.62	$2,911,170	121,009
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	4,921	$266.66	$1,312,234	131,887
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Open-market sell S	Common Stock	4,220	$265.57	$1,120,705	136,808
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	24,349	$155.57	$3,787,974	141,028
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	4,470	$91.05	$406,994	116,679
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	35,502	$96.87	$3,439,079	112,209
2020-05-05	LEIDEN JEFFREY M	Executive Chairman	Exercise / conversion M	Common Stock	24,216	$187.53	$4,541,226	76,707
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,942	$0.00	$0	5,825
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	9,310	$0.00	$0	24,690
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M · derivative	Stock Option (Right to Buy)	32,500	$0.00	$0	0
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	12,940	$264.92	$3,428,065	35,103
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	964	$263.58	$254,091	48,043
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	9,447	$262.69	$2,481,632	49,007
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	4,395	$261.68	$1,150,084	58,454
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	8,383	$260.48	$2,183,604	62,849
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	6,223	$259.63	$1,615,677	71,232
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Open-market sell S	Common Stock	1,400	$258.59	$362,026	77,455
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M	Common Stock	1,942	$86.52	$168,022	78,855
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M	Common Stock	9,310	$131.89	$1,227,896	76,913
2020-05-04	Sachdev Amit	EVP, Chief Patient Officer	Exercise / conversion M	Common Stock	32,500	$109.14	$3,547,050	67,603
2020-04-30	WAGNER CHARLES F JR	EVP and CFO	Other disposed transaction F	Common Stock	547	$251.78	$137,724	16,727
2020-04-29	Parini Michael	EVP, Chief Adm, Leg & BD Off	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,125	$0.00	$0	2,125
2020-04-29	Parini Michael	EVP, Chief Adm, Leg & BD Off	Open-market sell S	Common Stock	100	$258.15	$25,815	26,838
2020-04-29	Parini Michael	EVP, Chief Adm, Leg & BD Off	Open-market sell S	Common Stock	500	$256.63	$128,315	26,938
2020-04-29	Parini Michael	EVP, Chief Adm, Leg & BD Off	Open-market sell S	Common Stock	680	$255.44	$173,699	27,438
2020-04-29	Parini Michael	EVP, Chief Adm, Leg & BD Off	Open-market sell S	Common Stock	400	$254.20	$101,680	28,118
2020-04-29	Parini Michael	EVP, Chief Adm, Leg & BD Off	Open-market sell S	Common Stock	300	$252.70	$75,810	28,518
2020-04-29	Parini Michael	EVP, Chief Adm, Leg & BD Off	Open-market sell S	Common Stock	145	$251.38	$36,450	28,818
2020-04-29	Parini Michael	EVP, Chief Adm, Leg & BD Off	Exercise / conversion M	Common Stock	2,125	$90.29	$191,866	28,963
2020-04-28	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	1,125	$0.00	$0	0
2020-04-28	Lee Yuchun	Dir	Open-market sell S	Common Stock	116	$261.80	$30,369	1,875
2020-04-28	Lee Yuchun	Dir	Open-market sell S	Common Stock	180	$260.53	$46,895	1,991
2020-04-28	Lee Yuchun	Dir	Open-market sell S	Common Stock	120	$259.61	$31,153	2,171
2020-04-28	Lee Yuchun	Dir	Open-market sell S	Common Stock	149	$257.20	$38,323	2,411
2020-04-28	Lee Yuchun	Dir	Open-market sell S	Common Stock	240	$255.79	$61,390	2,560
2020-04-28	Lee Yuchun	Dir	Open-market sell S	Common Stock	200	$254.81	$50,962	2,800
2020-04-28	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	1,125	$57.27	$64,429	3,000
2020-04-27	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	1,125
2020-04-27	Lee Yuchun	Dir	Open-market sell S	Common Stock	100	$273.44	$27,344	1,875
2020-04-27	Lee Yuchun	Dir	Open-market sell S	Common Stock	200	$272.51	$54,502	1,975
2020-04-27	Lee Yuchun	Dir	Open-market sell S	Common Stock	1,113	$271.56	$302,246	2,175
2020-04-27	Lee Yuchun	Dir	Open-market sell S	Common Stock	394	$270.37	$106,526	3,288
2020-04-27	Lee Yuchun	Dir	Open-market sell S	Common Stock	193	$268.40	$51,801	3,682
2020-04-27	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$57.27	$114,540	3,875
2020-04-24	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	3,125
2020-04-24	Lee Yuchun	Dir	Open-market sell S	Common Stock	120	$270.30	$32,436	1,875
2020-04-24	Lee Yuchun	Dir	Open-market sell S	Common Stock	400	$269.28	$107,712	1,995
2020-04-24	Lee Yuchun	Dir	Open-market sell S	Common Stock	590	$268.31	$158,303	2,395
2020-04-24	Lee Yuchun	Dir	Open-market sell S	Common Stock	890	$267.23	$237,835	2,985
2020-04-24	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$57.27	$114,540	3,875
2020-04-23	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	5,125
2020-04-23	Lee Yuchun	Dir	Open-market sell S	Common Stock	47	$276.45	$12,993	1,875
2020-04-23	Lee Yuchun	Dir	Open-market sell S	Common Stock	600	$275.90	$165,540	1,922
2020-04-23	Lee Yuchun	Dir	Open-market sell S	Common Stock	400	$274.23	$109,692	2,522
2020-04-23	Lee Yuchun	Dir	Open-market sell S	Common Stock	100	$272.55	$27,255	2,922
2020-04-23	Lee Yuchun	Dir	Open-market sell S	Common Stock	300	$271.03	$81,309	3,022
2020-04-23	Lee Yuchun	Dir	Open-market sell S	Common Stock	200	$269.23	$53,846	3,322
2020-04-23	Lee Yuchun	Dir	Open-market sell S	Common Stock	353	$267.47	$94,417	3,522
2020-04-23	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$57.27	$114,540	3,875
2020-04-22	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	7,125
2020-04-22	Lee Yuchun	Dir	Open-market sell S	Common Stock	369	$270.54	$99,829	1,875
2020-04-22	Lee Yuchun	Dir	Open-market sell S	Common Stock	224	$268.48	$60,140	2,544
2020-04-22	Lee Yuchun	Dir	Open-market sell S	Common Stock	507	$267.34	$135,541	2,768
2020-04-22	Lee Yuchun	Dir	Open-market sell S	Common Stock	300	$269.47	$80,841	2,244
2020-04-22	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$57.27	$114,540	3,875
2020-04-21	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	9,125
2020-04-21	Lee Yuchun	Dir	Open-market sell S	Common Stock	100	$272.63	$27,263	1,875
2020-04-21	Lee Yuchun	Dir	Open-market sell S	Common Stock	403	$267.15	$107,661	2,375
2020-04-21	Lee Yuchun	Dir	Open-market sell S	Common Stock	300	$271.38	$81,414	1,975
2020-04-21	Lee Yuchun	Dir	Open-market sell S	Common Stock	500	$264.80	$132,400	3,078
2020-04-21	Lee Yuchun	Dir	Open-market sell S	Common Stock	297	$263.20	$78,170	3,578
2020-04-21	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$57.27	$114,540	3,875
2020-04-20	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	11,125
2020-04-20	Lee Yuchun	Dir	Open-market sell S	Common Stock	500	$274.65	$137,325	1,875
2020-04-20	Lee Yuchun	Dir	Open-market sell S	Common Stock	890	$273.61	$243,513	2,375
2020-04-20	Lee Yuchun	Dir	Open-market sell S	Common Stock	510	$271.52	$138,475	3,265
2020-04-20	Lee Yuchun	Dir	Open-market sell S	Common Stock	100	$269.97	$26,997	3,775
2020-04-20	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$57.27	$114,540	3,875
2020-04-15	SACHS BRUCE I	Dir	Equity grant / award A · derivative	Deferred Stock Units	179	$258.56	$46,250	12,277
2020-04-13	Silva Paul M	SVP & Controller	Exercise / conversion M · derivative	Stock Option (Right to Buy)	859	$0.00	$0	860
2020-04-13	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	166	$252.26	$41,875	14,932
2020-04-13	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	193	$250.29	$48,306	15,098
2020-04-13	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	150	$248.96	$37,344	15,291
2020-04-13	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	50	$244.09	$12,204	15,741
2020-04-13	Silva Paul M	SVP & Controller	Exercise / conversion M	Common Stock	859	$90.29	$77,559	15,791
2020-04-06	Silva Paul M	SVP & Controller	Exercise / conversion M · derivative	Stock Option (Right to Buy)	4,891	$0.00	$0	4,892
2020-04-06	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	4,891	$255.57	$1,249,993	14,932
2020-04-06	Silva Paul M	SVP & Controller	Exercise / conversion M	Common Stock	4,891	$155.57	$760,893	19,823
2020-03-31	LEIDEN JEFFREY M	Executive Chairman	Other disposed transaction F	Common Stock	40,090	$234.01	$9,381,461	52,491
2020-02-24	WAGNER CHARLES F JR	EVP and CFO	Other disposed transaction F	Common Stock	542	$239.23	$129,663	17,274
2020-02-18	Tatsis Ourania	SVP, CRO	Open-market sell S	Common Stock	145	$245.75	$35,634	15,070
2020-02-18	Tatsis Ourania	SVP, CRO	Open-market sell S	Common Stock	286	$244.99	$70,067	15,215
2020-02-18	Tatsis Ourania	SVP, CRO	Open-market sell S	Common Stock	528	$242.78	$128,188	15,661
2020-02-18	Tatsis Ourania	SVP, CRO	Open-market sell S	Common Stock	160	$243.78	$39,005	15,501
2020-02-17	Tatsis Ourania	SVP, CRO	Other disposed transaction F	Common Stock	597	$241.50	$144,176	16,349
2020-02-11	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	1,102	$247.93	$273,219	19,688
2020-02-11	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	1,120	$246.84	$276,461	20,790
2020-02-11	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	1,700	$245.89	$418,013	21,910
2020-02-11	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	1,560	$244.90	$382,044	23,610
2020-02-11	Silva Paul M	SVP & Controller	Open-market sell S	Common Stock	380	$243.59	$92,564	25,170
2020-02-10	Silva Paul M	SVP & Controller	Other disposed transaction F	Common Stock	4,673	$240.95	$1,125,959	25,550
2020-02-07	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	14,306
2020-02-07	Lee Yuchun	Dir	Open-market sell S	Common Stock	600	$239.96	$143,976	1,875
2020-02-07	Lee Yuchun	Dir	Open-market sell S	Common Stock	700	$237.51	$166,257	2,675
2020-02-07	Lee Yuchun	Dir	Open-market sell S	Common Stock	200	$238.50	$47,700	2,475
2020-02-07	Lee Yuchun	Dir	Open-market sell S	Common Stock	300	$234.84	$70,452	3,575
2020-02-07	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$57.27	$114,540	3,875
2020-02-06	Lee Yuchun	Dir	Exercise / conversion M · derivative	Stock Option (Right to Buy)	2,000	$0.00	$0	16,306
2020-02-06	Lee Yuchun	Dir	Open-market sell S	Common Stock	100	$244.08	$24,408	1,875
2020-02-06	Lee Yuchun	Dir	Open-market sell S	Common Stock	429	$240.65	$103,239	1,975
2020-02-06	Lee Yuchun	Dir	Open-market sell S	Common Stock	400	$239.28	$95,712	2,404
2020-02-06	Lee Yuchun	Dir	Open-market sell S	Common Stock	1,071	$238.71	$255,658	2,804
2020-02-06	Lee Yuchun	Dir	Exercise / conversion M	Common Stock	2,000	$57.27	$114,540	3,875
2020-02-05	WAGNER CHARLES F JR	EVP and CFO	Equity grant / award A	Common Stock	10,323	$0.00	$0	17,816
2020-02-05	WAGNER CHARLES F JR	EVP and CFO	Equity grant / award A	Common Stock	3,698	$0.00	$0	7,493
2020-02-05	LEIDEN JEFFREY M	CEO & President	Equity grant / award A	Common Stock	31,462	$0.00	$0	216,818
2020-02-05	LEIDEN JEFFREY M	CEO & President	Equity grant / award A	Common Stock	28,444	$0.00	$0	185,356
2020-02-05	LEIDEN JEFFREY M	CEO & President	Equity grant / award A	Common Stock	50,566	$0.00	$0	156,912

Regulatory Activity

Last 12 months to 2025-04-29

Insider Filings (Forms 3/4/5) — 12 months

Material Event Filings (8-K) — 12 months

8-K Material Event Filing Activity

Monthly count

Insider Trading Activity (Forms 3/4/5)

Monthly count